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Supplementary Figure 1 The GPCR DCAR-1 controls AMP gene expression following fungal infection and wounding. Normalized fluorescence ratio in wild type and dcar-1(tm2484) worms carrying the integrated array frIs7 (which contains the reportertransgenes nlp-29p::gfp and col-12p::DsRed) after infection by D. coniospora (left panel), wounding (middle left panel) and osmotic stress(middle right panel), and in wild type and dcar-1(tm2484) worms that in addition to frIs7 carry frIs30, an integrated transgene that encodes aconstitutively active form of GPA-12 (GPA-12*; right panel). In all cases, the results are representative of at least three independentexperiments with a minimum of 50 worms for each condition.
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 2
DCAR-1 acts in an epidermis-specific and cell-autonomous manner to regulate the induction of nlp-29 AMP gene.
a, Normalized fluorescence ratio of wild type worms carrying frIs7 treated with RNAi against control (sta-1, gfp, sta-2) or candidate genes(osm-9 and ocr-2) and infected or not. b, Normalized fluorescence ratio of worms carrying frIs7 in rde-1(ne219);col-19p::rde-1 worms that areresistant to RNAi except in the adult epidermis treated with RNAi against control genes (sta-1, gfp, sta-2) or dcar-1 and infected or not. Theresults are representative of at least three independent experiments with a minimum of 50 worms for each condition.
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 3
DCAR-1 acts in the epidermis to regulate nlp gene expression and resistance to infection with D. coniospora.
a, Survival of wild-type, dcar-1(tm2484), dcar-1;dcar-1p::dcar-1::gfp, dcar-1;col-12p::dcar-1::gfp and sra-6p::dcar-1::Venus worms afterinfection with D. coniospora. For the experiment shown here, n= 70, 65, 67, 67 and 70 respectively). The statistical significance of thedifferences between strains is shown below the graph (one-sided log rank test). b, c Quantitative RT-PCR analysis of the expression of genesin the nlp-29 cluster in wild-type, dcar-1(tm2484) and dcar-1;dcar-1p::dcar-1::gfp (b) or wild-type, dcar-1(tm2484), dcar-1;col-12p::dcar-1 anddcar-1;sra-6p::dcar-1 worms (c) after infection with D. coniospora. Data are from three independent experiments (average and SD). d,Survival of wild-type, dcar-1(tm2484), dcar-1;col-12p::dcar-1 and with sra-6p::dcar-1 worms after infection with D. coniospora. For theexperiment shown here, n= 62, 71, 55 and 65 respectively). The statistical significance of the difference between strains is shown below thegraph (one-sided log rank test). The difference in survival between the strains common to the experiments shown in a and d is linked to avariation in pathogenicity between different preparations of fungal spores used in experiments performed on different days.
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 4
DHCA triggers PMK-1-dependent gene expression in the epidermis.
Quantitative RT-PCR analysis of the expression of genes in the nlp-29 cluster in wild-type and pmk-1 worms treated with 5 mM DHCA for 2 h(a) or of the intestinal defence genes F49F1.6 and F57F4.4 (that require PMK-1 for their expression) and pgp-5, irg-1, irg-3 (that do notrequire PMK-1 for their expression)1,2 in wild-type and dcar-1(tm2484) worms after exposure to 5 mM DHCA for 2 h (b) or 5 h (c). Data arefrom three independent experiments (average and SD). The qualitative effect on nlp gene expression in the pmk-1 mutant mirrors that seenupon infection3, also with an apparent partial pmk-1-independent component for the induction of nlp-31 and nlp-34. Although exposure ofworms to DHCA was sufficient to increase epidermal AMP gene expression, pre-treatment of worms with it did not provide any measurableprotection against infection (results not shown).
1 - Estes, K. A., Dunbar, T. L., Powell, J. R., Ausubel, F. M. & Troemel, E. R. bZIP transcription factor zip-2 mediates an early response to Pseudomonasaeruginosa infection in Caenorhabditis elegans. Proc Natl Acad Sci U S A 107, 2153-2158 (2010).
2 - Dierking, K. et al. Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity. Cell Host Microbe 9, 425-435 (2011).
3 - Pujol, N. et al. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol 18, 481-489 (2008).
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 5
Molecules that are structurally related to DHCA but do not trigger expression of the nlp-29p::gfp reporter gene.
Chemical structures of 3,4-hydroxy phenyl propionic acid (HPA), 4-hydroxyphenylpyruvic acid (HPPA), 3-4-dihydroxyphenyl lactic acid(DPLA), tyrosine, L-3,4-dihydroxyphenylalanine (DOPA), 3,4-dihydrobenzaldehyde (DHB), 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihyroxybenzoic acid (DHBA), and 3,4 dihydroxymandelic acid (DHMA), together with normalized fluorescence ratio of young adult wild typeworms carrying frIs7 treated for 2 h at 25°C with increasing concentrations of the indicated chemical. Data are representative of at least threeindependent experiments with a minimum of 50 worms for each condition. Compounds previously found to act as DCAR-1 ligands in aXenopus oocyte system, and their relative potency are indicated (*** medium; ** low; * weak). Tyrosine and DOPA were also tested and hadno effect4. As the epidermis of C. elegans is surrounded by a cuticle that is relatively impermeable to many compounds5-6, we cannot formallyexclude the possibility that lack of reporter gene expression in our assay results from a failure of a given compound to reach DCAR-1 in vivo.Nor can we exclude the possibility that different compounds have different pharmacokinetic properties.
4 - Aoki, R. et al. A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditiselegans. J Neurosci 31, 16603-16610 (2011).
5 - Partridge, F. A., Tearle, A. W., Gravato-Nobre, M. J., Schafer, W. R. & Hodgkin, J. The C. elegans glycosyltransferase BUS-8 has two distinct and essentialroles in epidermal morphogenesis. Dev Biol 317, 549-559 (2008).
6 - Zheng, S. Q., Ding, A. J., Li, G. P., Wu, G. S. & Luo, H. R. Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One 8,e56877 (2013).
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 6
Knocking down individual enzymes potentially involved in HPLA metabolism has no effect on nlp-29p::gfp expression.
a, Part of the tyrosine metabolic pathway, showing the names and structures of intermediates and the names of selected candidate enzymeswhich potentially catalyze each step. To the best of our knowledge, how the keto of HPPA is converted into the hydroxy function of HPLA hasnot been elucidated in any eukaryotic species. b, Normalized fluorescence ratio of young adult IG1502 rde-1(ne219) V; Is[wrt-2p::rde-1; myo-2p::rfp]; frIs7 IV worms that are resistant to RNAi except in the epidermis (infected or not, left panel) or dpy-10 worms (right panel) carryingfrIs7 treated with RNAi against control (sta-1, gfp and dcar-1) or candidate genes. Data are representative of at least two independentexperiments with a minimum of 50 worms for each condition.
Nature Immunology: doi:10.1038/ni.2957
Supplementary Figure 7
Pathways leading to expression of nlp-29, highlighting the newly discovered roles of HPLA and DCAR-1.
Infection with D. coniospora and physical injury trigger up-regulation of the AMP nlp genes in the epidermis via the Gα protein GPA-12 thatacts upstream of the PKC∂ TPA-1, the TIR-domain adapter protein TIR-1 and a p38 MAPK cascade involving NSY-1, SEK-1 and PMK-1, aswell as the STAT transcription factor-like protein STA-2. We found that the level of HPLA, which is potentially derived from tyrosine, increasesupon infection. The precise site and mode of production of HPLA awaits elucidation; tyrosine is placed here at the level of the cuticle for thepurpose of illustration. HPLA triggers nlp-29 gene expression via its cognate receptor DCAR-1, which is expressed at the apical surface of theepidermal syncytium hyp7. DCAR-1 acts upstream of GPA-12, the p38 MAPK cassette and STA-2.
Nature Immunology: doi:10.1038/ni.2957
Table S1: GPCR genes in the C. elegans genome Gene WB IDa,b Public gene namea,b WBGene00000085 aex-‐2 WBGene00020712 ckr-‐1 WBGene00021439 ckr-‐2 WBGene00013285 dct-‐12 WBGene00001052 dop-‐1 WBGene00001053 dop-‐2 WBGene00020506 dop-‐3 WBGene00016872 dop-‐4 WBGene00011382 dop-‐5 WBGene00016037 dop-‐6 WBGene00001175 egl-‐6 WBGene00001214 ego-‐1 WBGene00001475 fmi-‐1 WBGene00008239 fshr-‐1 WBGene00001517 gar-‐1 WBGene00001518 gar-‐2 WBGene00001519 gar-‐3 WBGene00021528 gbb-‐1 WBGene00022675 gbb-‐2 WBGene00013591 gcn-‐2 WBGene00018798 gnrr-‐1 WBGene00007614 gnrr-‐2 WBGene00013871 gnrr-‐3 WBGene00016570 gnrr-‐4 WBGene00019224 gnrr-‐5 WBGene00008736 gnrr-‐6 WBGene00008737 gnrr-‐7 WBGene00013642 gnrr-‐8 WBGene00002251 lat-‐1 WBGene00002252 lat-‐2 WBGene00003232 mgl-‐1 WBGene00003233 mgl-‐2 WBGene00021152 mgl-‐3 WBGene00017198 nhr-‐36 WBGene00020015 nhr-‐210 WBGene00016747 nmur-‐1 WBGene00019616 nmur-‐2 WBGene00017176 nmur-‐3
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WBGene00016265 nmur-‐4 WBGene00003807 npr-‐1 WBGene00003808 npr-‐2 WBGene00007006 npr-‐3 WBGene00013974 npr-‐9 WBGene00008278 npr-‐10 WBGene00016110 npr-‐11 WBGene00020689 npr-‐12 WBGene00013883 npr-‐13 WBGene00012275 npr-‐14 WBGene00012084 npr-‐15 WBGene00006864 npr-‐16 WBGene00015559 npr-‐17 WBGene00008065 npr-‐18 WBGene00015364 npr-‐19 WBGene00011578 npr-‐20 WBGene00006411 octr-‐1 WBGene00003856 odr-‐10 WBGene00005744 ops-‐1 WBGene00015735 pdfr-‐1 WBGene00007761 rad-‐26 WBGene00004776 ser-‐1 WBGene00004777 ser-‐2 WBGene00004778 ser-‐3 WBGene00004779 ser-‐4 WBGene00008890 ser-‐5 WBGene00021897 ser-‐6 WBGene00004780 ser-‐7 WBGene00010986 sprr-‐1 WBGene00009629 sprr-‐2 WBGene00022086 sprr-‐3 WBGene00005027 sra-‐1 WBGene00005028 sra-‐2 WBGene00005029 sra-‐3 WBGene00005030 sra-‐4 WBGene00005032 sra-‐6 WBGene00005033 sra-‐7 WBGene00005034 sra-‐8 WBGene00005035 sra-‐9 WBGene00005036 sra-‐10 WBGene00005037 sra-‐11
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WBGene00005038 sra-‐12 WBGene00005039 sra-‐13 WBGene00005040 sra-‐14 WBGene00005043 sra-‐17 WBGene00005044 sra-‐18 WBGene00005046 sra-‐20 WBGene00005047 sra-‐21 WBGene00005048 sra-‐22 WBGene00005049 sra-‐23 WBGene00005050 sra-‐24 WBGene00005051 sra-‐25 WBGene00005052 sra-‐26 WBGene00005053 sra-‐27 WBGene00005054 sra-‐28 WBGene00005055 sra-‐29 WBGene00005056 sra-‐30 WBGene00005057 sra-‐31 WBGene00005058 sra-‐32 WBGene00005059 sra-‐33 WBGene00005060 sra-‐34 WBGene00005061 sra-‐35 WBGene00005062 sra-‐36 WBGene00005063 sra-‐37 WBGene00005064 sra-‐38 WBGene00005065 sra-‐39 WBGene00015446 srab-‐1 WBGene00015447 srab-‐2 WBGene00015448 srab-‐3 WBGene00016363 srab-‐4 WBGene00016479 srab-‐6 WBGene00016480 srab-‐7 WBGene00016475 srab-‐9 WBGene00016476 srab-‐10 WBGene00008128 srab-‐12 WBGene00019091 srab-‐13 WBGene00019999 srab-‐14 WBGene00011701 srab-‐17 WBGene00011702 srab-‐18 WBGene00020607 srab-‐20 WBGene00020623 srab-‐21 WBGene00020608 srab-‐22
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WBGene00021488 srab-‐23 WBGene00013417 srab-‐24 WBGene00022807 srab-‐25 WBGene00043059 srab-‐26 WBGene00005066 srb-‐1 WBGene00005067 srb-‐2 WBGene00005068 srb-‐3 WBGene00005070 srb-‐5 WBGene00005071 srb-‐6 WBGene00005072 srb-‐7 WBGene00005073 srb-‐8 WBGene00005074 srb-‐9 WBGene00005076 srb-‐11 WBGene00019027 srb-‐12 WBGene00019028 srb-‐13 WBGene00016743 srb-‐15 WBGene00019025 srb-‐16 WBGene00008489 srb-‐17 WBGene00016925 srb-‐18 WBGene00016928 srb-‐19 WBGene00018058 srbc-‐1 WBGene00015438 srbc-‐2 WBGene00018053 srbc-‐3 WBGene00020874 srbc-‐5 WBGene00016472 srbc-‐6 WBGene00015961 srbc-‐7 WBGene00015962 srbc-‐8 WBGene00015960 srbc-‐9 WBGene00015959 srbc-‐10 WBGene00015958 srbc-‐11 WBGene00019559 srbc-‐13 WBGene00011485 srbc-‐14 WBGene00016688 srbc-‐18 WBGene00016696 srbc-‐19 WBGene00016689 srbc-‐21 WBGene00016690 srbc-‐22 WBGene00016691 srbc-‐23 WBGene00016692 srbc-‐24 WBGene00009567 srbc-‐25 WBGene00009568 srbc-‐26 WBGene00044100 srbc-‐27
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WBGene00015315 srbc-‐29 WBGene00015316 srbc-‐30 WBGene00044089 srbc-‐31 WBGene00015317 srbc-‐32 WBGene00021166 srbc-‐42 WBGene00013908 srbc-‐43 WBGene00013909 srbc-‐44 WBGene00013910 srbc-‐45 WBGene00010021 srbc-‐49 WBGene00044091 srbc-‐60 WBGene00011840 srbc-‐62 WBGene00021477 srbc-‐64 WBGene00020746 srbc-‐66 WBGene00011506 srbc-‐77 WBGene00005079 srd-‐1 WBGene00005080 srd-‐2 WBGene00005081 srd-‐3 WBGene00005082 srd-‐4 WBGene00005083 srd-‐5 WBGene00005085 srd-‐7 WBGene00005086 srd-‐8 WBGene00005087 srd-‐9 WBGene00005088 srd-‐10 WBGene00005089 srd-‐11 WBGene00005090 srd-‐12 WBGene00005091 srd-‐13 WBGene00005093 srd-‐15 WBGene00005094 srd-‐16 WBGene00005095 srd-‐17 WBGene00005096 srd-‐18 WBGene00005097 srd-‐19 WBGene00005098 srd-‐20 WBGene00005099 srd-‐21 WBGene00005101 srd-‐23 WBGene00005103 srd-‐25 WBGene00005104 srd-‐26 WBGene00005105 srd-‐27 WBGene00005106 srd-‐28 WBGene00005107 srd-‐29 WBGene00005108 srd-‐30 WBGene00005109 srd-‐31
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WBGene00005110 srd-‐32 WBGene00005111 srd-‐33 WBGene00005112 srd-‐34 WBGene00005113 srd-‐35 WBGene00005114 srd-‐36 WBGene00005116 srd-‐38 WBGene00005117 srd-‐39 WBGene00005118 srd-‐40 WBGene00005119 srd-‐41 WBGene00005120 srd-‐42 WBGene00005121 srd-‐43 WBGene00005122 srd-‐44 WBGene00005123 srd-‐45 WBGene00005124 srd-‐46 WBGene00005125 srd-‐47 WBGene00005126 srd-‐48 WBGene00005127 srd-‐49 WBGene00005128 srd-‐50 WBGene00005129 srd-‐51 WBGene00005131 srd-‐53 WBGene00005133 srd-‐55 WBGene00005134 srd-‐56 WBGene00005135 srd-‐58 WBGene00005136 srd-‐59 WBGene00005137 srd-‐60 WBGene00005138 srd-‐61 WBGene00005140 srd-‐63 WBGene00005141 srd-‐64 WBGene00005142 srd-‐65 WBGene00005143 srd-‐66 WBGene00005144 srd-‐67 WBGene00005145 srd-‐68 WBGene00005146 srd-‐69 WBGene00005147 srd-‐70 WBGene00005148 srd-‐71 WBGene00021572 srd-‐72 WBGene00021570 srd-‐73 WBGene00007701 srd-‐74 WBGene00044099 srd-‐75 WBGene00005149 sre-‐1 WBGene00005150 sre-‐2
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WBGene00011745 sre-‐4 WBGene00015036 sre-‐5 WBGene00009596 sre-‐8 WBGene00015898 sre-‐9 WBGene00015712 sre-‐11 WBGene00020333 sre-‐12 WBGene00012709 sre-‐15 WBGene00012707 sre-‐16 WBGene00008126 sre-‐21 WBGene00013957 sre-‐23 WBGene00016833 sre-‐51 WBGene00016831 sre-‐56 WBGene00005159 srg-‐1 WBGene00005160 srg-‐2 WBGene00005161 srg-‐3 WBGene00005162 srg-‐4 WBGene00005163 srg-‐5 WBGene00005164 srg-‐6 WBGene00005165 srg-‐7 WBGene00005166 srg-‐8 WBGene00005167 srg-‐9 WBGene00005168 srg-‐10 WBGene00005169 srg-‐11 WBGene00005170 srg-‐13 WBGene00005171 srg-‐14 WBGene00005172 srg-‐15 WBGene00005173 srg-‐16 WBGene00005174 srg-‐17 WBGene00005176 srg-‐19 WBGene00005177 srg-‐20 WBGene00005178 srg-‐21 WBGene00005179 srg-‐22 WBGene00005180 srg-‐23 WBGene00005181 srg-‐24 WBGene00005182 srg-‐25 WBGene00005183 srg-‐26 WBGene00005184 srg-‐27 WBGene00005185 srg-‐28 WBGene00005186 srg-‐29 WBGene00005187 srg-‐30 WBGene00005188 srg-‐31
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WBGene00005189 srg-‐32 WBGene00005190 srg-‐33 WBGene00005191 srg-‐34 WBGene00005193 srg-‐36 WBGene00005194 srg-‐37 WBGene00005195 srg-‐38 WBGene00005196 srg-‐39 WBGene00005197 srg-‐40 WBGene00005198 srg-‐41 WBGene00005199 srg-‐42 WBGene00005201 srg-‐44 WBGene00005202 srg-‐45 WBGene00005203 srg-‐46 WBGene00005204 srg-‐47 WBGene00005205 srg-‐48 WBGene00005207 srg-‐50 WBGene00005208 srg-‐51 WBGene00005210 srg-‐53 WBGene00005211 srg-‐54 WBGene00005212 srg-‐55 WBGene00005213 srg-‐56 WBGene00005214 srg-‐57 WBGene00005215 srg-‐58 WBGene00005216 srg-‐59 WBGene00005217 srg-‐60 WBGene00005218 srg-‐61 WBGene00005219 srg-‐62 WBGene00005221 srg-‐64 WBGene00005222 srg-‐65 WBGene00005223 srg-‐66 WBGene00005224 srg-‐67 WBGene00005225 srg-‐68 WBGene00005226 srg-‐69 WBGene00005227 srh-‐1 WBGene00005228 srh-‐2 WBGene00005229 srh-‐3 WBGene00005230 srh-‐4 WBGene00005231 srh-‐5 WBGene00005233 srh-‐7 WBGene00005234 srh-‐8 WBGene00005236 srh-‐10
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WBGene00005237 srh-‐11 WBGene00005240 srh-‐15 WBGene00005241 srh-‐16 WBGene00005242 srh-‐17 WBGene00005243 srh-‐18 WBGene00005244 srh-‐19 WBGene00005245 srh-‐20 WBGene00005246 srh-‐21 WBGene00005247 srh-‐22 WBGene00005248 srh-‐23 WBGene00011192 srh-‐24 WBGene00005249 srh-‐25 WBGene00005250 srh-‐27 WBGene00005251 srh-‐28 WBGene00005253 srh-‐30 WBGene00005254 srh-‐31 WBGene00005255 srh-‐32 WBGene00005256 srh-‐33 WBGene00005257 srh-‐34 WBGene00005258 srh-‐35 WBGene00005259 srh-‐36 WBGene00005260 srh-‐37 WBGene00005261 srh-‐38 WBGene00005262 srh-‐39 WBGene00005263 srh-‐40 WBGene00005264 srh-‐41 WBGene00005265 srh-‐42 WBGene00005267 srh-‐44 WBGene00005268 srh-‐45 WBGene00005269 srh-‐46 WBGene00005270 srh-‐47 WBGene00005271 srh-‐48 WBGene00005272 srh-‐49 WBGene00005273 srh-‐50 WBGene00005274 srh-‐51 WBGene00005275 srh-‐52 WBGene00005278 srh-‐55 WBGene00005279 srh-‐56 WBGene00005280 srh-‐57 WBGene00005281 srh-‐59 WBGene00005282 srh-‐60
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WBGene00005283 srh-‐61 WBGene00005284 srh-‐62 WBGene00005285 srh-‐63 WBGene00005288 srh-‐67 WBGene00005289 srh-‐68 WBGene00005290 srh-‐69 WBGene00005291 srh-‐70 WBGene00005292 srh-‐71 WBGene00005293 srh-‐72 WBGene00005294 srh-‐73 WBGene00005295 srh-‐74 WBGene00005296 srh-‐75 WBGene00005297 srh-‐76 WBGene00005298 srh-‐77 WBGene00005299 srh-‐78 WBGene00005300 srh-‐79 WBGene00005301 srh-‐80 WBGene00005303 srh-‐82 WBGene00005304 srh-‐83 WBGene00005308 srh-‐87 WBGene00005309 srh-‐88 WBGene00005310 srh-‐89 WBGene00005313 srh-‐92 WBGene00005315 srh-‐95 WBGene00005316 srh-‐97 WBGene00005317 srh-‐98 WBGene00005318 srh-‐99 WBGene00005319 srh-‐100 WBGene00005321 srh-‐102 WBGene00005323 srh-‐104 WBGene00005512 srh-‐105 WBGene00005328 srh-‐109 WBGene00005330 srh-‐111 WBGene00005331 srh-‐112 WBGene00005332 srh-‐113 WBGene00005334 srh-‐115 WBGene00005335 srh-‐116 WBGene00005337 srh-‐118 WBGene00005338 srh-‐119 WBGene00005339 srh-‐120 WBGene00005340 srh-‐122
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WBGene00005341 srh-‐123 WBGene00005342 srh-‐125 WBGene00005344 srh-‐127 WBGene00005345 srh-‐128 WBGene00005346 srh-‐129 WBGene00005347 srh-‐130 WBGene00005348 srh-‐131 WBGene00005349 srh-‐132 WBGene00005350 srh-‐133 WBGene00005351 srh-‐134 WBGene00005352 srh-‐135 WBGene00005353 srh-‐136 WBGene00005354 srh-‐137 WBGene00005355 srh-‐138 WBGene00005356 srh-‐139 WBGene00005357 srh-‐140 WBGene00005358 srh-‐141 WBGene00005359 srh-‐142 WBGene00005361 srh-‐145 WBGene00005363 srh-‐147 WBGene00005364 srh-‐148 WBGene00005365 srh-‐149 WBGene00005370 srh-‐154 WBGene00005375 srh-‐159 WBGene00005381 srh-‐165 WBGene00005382 srh-‐166 WBGene00005383 srh-‐167 WBGene00005385 srh-‐169 WBGene00005386 srh-‐170 WBGene00005387 srh-‐171 WBGene00005388 srh-‐172 WBGene00005389 srh-‐173 WBGene00005390 srh-‐174 WBGene00005392 srh-‐177 WBGene00005393 srh-‐178 WBGene00005394 srh-‐179 WBGene00005395 srh-‐180 WBGene00005396 srh-‐181 WBGene00005397 srh-‐182 WBGene00005398 srh-‐183 WBGene00005399 srh-‐184
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WBGene00005400 srh-‐185 WBGene00005401 srh-‐186 WBGene00005402 srh-‐187 WBGene00005404 srh-‐190 WBGene00005405 srh-‐192 WBGene00005406 srh-‐193 WBGene00005407 srh-‐194 WBGene00005408 srh-‐195 WBGene00005410 srh-‐199 WBGene00005411 srh-‐200 WBGene00005412 srh-‐201 WBGene00005414 srh-‐203 WBGene00005415 srh-‐204 WBGene00005416 srh-‐206 WBGene00005417 srh-‐207 WBGene00005418 srh-‐208 WBGene00005419 srh-‐209 WBGene00005420 srh-‐210 WBGene00005421 srh-‐211 WBGene00005422 srh-‐212 WBGene00005423 srh-‐213 WBGene00005424 srh-‐214 WBGene00005425 srh-‐215 WBGene00005426 srh-‐216 WBGene00005427 srh-‐217 WBGene00005428 srh-‐218 WBGene00005429 srh-‐219 WBGene00005430 srh-‐220 WBGene00005432 srh-‐222 WBGene00005433 srh-‐223 WBGene00005435 srh-‐227 WBGene00005436 srh-‐228 WBGene00005437 srh-‐229 WBGene00005439 srh-‐231 WBGene00005440 srh-‐233 WBGene00005441 srh-‐234 WBGene00005442 srh-‐235 WBGene00005443 srh-‐236 WBGene00005446 srh-‐239 WBGene00005447 srh-‐240 WBGene00005448 srh-‐241
Nature Immunology: doi:10.1038/ni.2957
WBGene00005449 srh-‐243 WBGene00005450 srh-‐244 WBGene00005451 srh-‐245 WBGene00005452 srh-‐246 WBGene00005453 srh-‐247 WBGene00005454 srh-‐248 WBGene00005456 srh-‐250 WBGene00005457 srh-‐251 WBGene00005458 srh-‐252 WBGene00005461 srh-‐255 WBGene00005463 srh-‐257 WBGene00005464 srh-‐258 WBGene00005467 srh-‐261 WBGene00005470 srh-‐264 WBGene00005471 srh-‐265 WBGene00005472 srh-‐266 WBGene00005474 srh-‐268 WBGene00005475 srh-‐269 WBGene00005476 srh-‐270 WBGene00005477 srh-‐271 WBGene00005478 srh-‐272 WBGene00005479 srh-‐274 WBGene00005480 srh-‐275 WBGene00005481 srh-‐276 WBGene00005482 srh-‐277 WBGene00005483 srh-‐278 WBGene00005484 srh-‐279 WBGene00005486 srh-‐281 WBGene00005487 srh-‐282 WBGene00005488 srh-‐283 WBGene00005489 srh-‐284 WBGene00005490 srh-‐286 WBGene00005491 srh-‐287 WBGene00005492 srh-‐288 WBGene00005493 srh-‐289 WBGene00005494 srh-‐290 WBGene00005495 srh-‐291 WBGene00005496 srh-‐292 WBGene00005497 srh-‐293 WBGene00005499 srh-‐295 WBGene00005500 srh-‐296
Nature Immunology: doi:10.1038/ni.2957
WBGene00005501 srh-‐297 WBGene00005502 srh-‐298 WBGene00005503 srh-‐299 WBGene00005504 srh-‐300 WBGene00005505 srh-‐301 WBGene00005507 srh-‐303 WBGene00005508 srh-‐304 WBGene00005509 srh-‐305 WBGene00010261 srh-‐308 WBGene00005513 sri-‐1 WBGene00005514 sri-‐2 WBGene00005516 sri-‐4 WBGene00005517 sri-‐5 WBGene00005518 sri-‐6 WBGene00005519 sri-‐7 WBGene00005521 sri-‐9 WBGene00005522 sri-‐10 WBGene00005523 sri-‐11 WBGene00005524 sri-‐12 WBGene00005525 sri-‐13 WBGene00005526 sri-‐14 WBGene00005527 sri-‐15 WBGene00005528 sri-‐16 WBGene00005529 sri-‐17 WBGene00005530 sri-‐18 WBGene00005531 sri-‐19 WBGene00005532 sri-‐20 WBGene00005533 sri-‐21 WBGene00005536 sri-‐24 WBGene00005537 sri-‐25 WBGene00005538 sri-‐26 WBGene00005539 sri-‐27 WBGene00005540 sri-‐28 WBGene00005541 sri-‐29 WBGene00005542 sri-‐30 WBGene00005543 sri-‐31 WBGene00005544 sri-‐32 WBGene00005545 sri-‐33 WBGene00005546 sri-‐34 WBGene00005548 sri-‐36 WBGene00005549 sri-‐37
Nature Immunology: doi:10.1038/ni.2957
WBGene00005550 sri-‐38 WBGene00005551 sri-‐39 WBGene00005552 sri-‐40 WBGene00005554 sri-‐42 WBGene00005555 sri-‐43 WBGene00005557 sri-‐45 WBGene00005558 sri-‐46 WBGene00005559 sri-‐47 WBGene00005560 sri-‐48 WBGene00005562 sri-‐50 WBGene00005563 sri-‐51 WBGene00005565 sri-‐53 WBGene00005566 sri-‐54 WBGene00005569 sri-‐57 WBGene00005572 sri-‐60 WBGene00005573 sri-‐61 WBGene00005574 sri-‐62 WBGene00005575 sri-‐63 WBGene00005577 sri-‐65 WBGene00005578 sri-‐66 WBGene00005579 sri-‐67 WBGene00005581 sri-‐69 WBGene00005582 sri-‐70 WBGene00005583 sri-‐71 WBGene00005585 sri-‐73 WBGene00005586 sri-‐74 WBGene00005589 sri-‐77 WBGene00005590 sri-‐78 WBGene00005591 srj-‐1 WBGene00005592 srj-‐4 WBGene00005593 srj-‐5 WBGene00005594 srj-‐6 WBGene00005595 srj-‐7 WBGene00005596 srj-‐8 WBGene00005597 srj-‐9 WBGene00005598 srj-‐10 WBGene00005599 srj-‐11 WBGene00005601 srj-‐13 WBGene00005602 srj-‐14 WBGene00005603 srj-‐15 WBGene00005604 srj-‐16
Nature Immunology: doi:10.1038/ni.2957
WBGene00005606 srj-‐18 WBGene00005607 srj-‐19 WBGene00005608 srj-‐20 WBGene00005609 srj-‐21 WBGene00005610 srj-‐22 WBGene00005611 srj-‐23 WBGene00005612 srj-‐24 WBGene00005613 srj-‐25 WBGene00005614 srj-‐26 WBGene00005615 srj-‐27 WBGene00005616 srj-‐29 WBGene00005617 srj-‐32 WBGene00005618 srj-‐33 WBGene00005621 srj-‐37 WBGene00005622 srj-‐38 WBGene00005623 srj-‐39 WBGene00005624 srj-‐40 WBGene00005625 srj-‐42 WBGene00005626 srj-‐44 WBGene00005627 srj-‐45 WBGene00005628 srj-‐49 WBGene00005629 srj-‐50 WBGene00005632 srj-‐53 WBGene00005633 srj-‐54 WBGene00005634 srj-‐55 WBGene00005635 srj-‐57 WBGene00005638 srm-‐1 WBGene00005639 srm-‐2 WBGene00010273 srm-‐3 WBGene00009808 srm-‐4 WBGene00044112 srm-‐5 WBGene00009810 srm-‐6 WBGene00005640 srn-‐1 WBGene00005641 sro-‐1 WBGene00009566 srsx-‐1 WBGene00008982 srsx-‐2 WBGene00022408 srsx-‐3 WBGene00022404 srsx-‐5 WBGene00022405 srsx-‐6 WBGene00022406 srsx-‐7 WBGene00018709 srsx-‐8
Nature Immunology: doi:10.1038/ni.2957
WBGene00017845 srsx-‐9 WBGene00044117 srsx-‐10 WBGene00015736 srsx-‐11 WBGene00015737 srsx-‐12 WBGene00015738 srsx-‐13 WBGene00016543 srsx-‐14 WBGene00044124 srsx-‐15 WBGene00044125 srsx-‐16 WBGene00019032 srsx-‐17 WBGene00015419 srsx-‐18 WBGene00011931 srsx-‐19 WBGene00011084 srsx-‐21 WBGene00018180 srsx-‐22 WBGene00015401 srsx-‐24 WBGene00013375 srsx-‐25 WBGene00008247 srsx-‐26 WBGene00008248 srsx-‐27 WBGene00008249 srsx-‐28 WBGene00008250 srsx-‐29 WBGene00008251 srsx-‐30 WBGene00008552 srsx-‐31 WBGene00017615 srsx-‐32 WBGene00011837 srsx-‐33 WBGene00016093 srsx-‐34 WBGene00009999 srsx-‐35 WBGene00012055 srsx-‐36 WBGene00010800 srsx-‐37 WBGene00012054 srsx-‐38 WBGene00010802 srsx-‐39 WBGene00015730 srt-‐1 WBGene00021568 srt-‐2 WBGene00018554 srt-‐3 WBGene00016232 srt-‐4 WBGene00016859 srt-‐5 WBGene00020055 srt-‐6 WBGene00016852 srt-‐7 WBGene00016850 srt-‐8 WBGene00016853 srt-‐9 WBGene00012181 srt-‐11 WBGene00017107 srt-‐12 WBGene00022528 srt-‐13
Nature Immunology: doi:10.1038/ni.2957
WBGene00016856 srt-‐15 WBGene00016857 srt-‐16 WBGene00018617 srt-‐17 WBGene00019850 srt-‐18 WBGene00018552 srt-‐19 WBGene00018558 srt-‐20 WBGene00014191 srt-‐22 WBGene00021947 srt-‐23 WBGene00021951 srt-‐24 WBGene00015862 srt-‐25 WBGene00016051 srt-‐27 WBGene00016049 srt-‐28 WBGene00016050 srt-‐29 WBGene00019966 srt-‐30 WBGene00019740 srt-‐31 WBGene00008268 srt-‐32 WBGene00009603 srt-‐33 WBGene00018826 srt-‐34 WBGene00018555 srt-‐35 WBGene00018556 srt-‐36 WBGene00018559 srt-‐37 WBGene00018557 srt-‐38 WBGene00012242 srt-‐39 WBGene00021169 srt-‐40 WBGene00018114 srt-‐41 WBGene00021599 srt-‐42 WBGene00008937 srt-‐43 WBGene00010950 srt-‐44 WBGene00010929 srt-‐45 WBGene00012770 srt-‐47 WBGene00012773 srt-‐48 WBGene00012772 srt-‐49 WBGene00021413 srt-‐52 WBGene00022409 srt-‐53 WBGene00019614 srt-‐54 WBGene00011816 srt-‐55 WBGene00022266 srt-‐56 WBGene00016233 srt-‐58 WBGene00015998 srt-‐59 WBGene00020856 srt-‐61 WBGene00020857 srt-‐62
Nature Immunology: doi:10.1038/ni.2957
WBGene00015367 srt-‐64 WBGene00015069 srt-‐67 WBGene00016851 srt-‐71 WBGene00016478 srt-‐72 WBGene00020288 srt-‐73 WBGene00044002 srt-‐74 WBGene00015214 srtx-‐1 WBGene00005664 sru-‐1 WBGene00005665 sru-‐2 WBGene00005666 sru-‐3 WBGene00005667 sru-‐4 WBGene00005669 sru-‐6 WBGene00005670 sru-‐7 WBGene00005671 sru-‐8 WBGene00005672 sru-‐9 WBGene00005674 sru-‐11 WBGene00005675 sru-‐12 WBGene00005676 sru-‐13 WBGene00005678 sru-‐15 WBGene00005679 sru-‐16 WBGene00005680 sru-‐17 WBGene00005681 sru-‐18 WBGene00005682 sru-‐19 WBGene00005683 sru-‐20 WBGene00005684 sru-‐21 WBGene00005685 sru-‐22 WBGene00005686 sru-‐23 WBGene00005687 sru-‐24 WBGene00005688 sru-‐25 WBGene00005689 sru-‐26 WBGene00005690 sru-‐27 WBGene00005691 sru-‐28 WBGene00005692 sru-‐29 WBGene00005693 sru-‐30 WBGene00005694 sru-‐31 WBGene00005696 sru-‐33 WBGene00005698 sru-‐35 WBGene00005699 sru-‐36 WBGene00005700 sru-‐37 WBGene00005701 sru-‐38 WBGene00005702 sru-‐39
Nature Immunology: doi:10.1038/ni.2957
WBGene00005703 sru-‐40 WBGene00005705 sru-‐42 WBGene00005708 sru-‐45 WBGene00005710 sru-‐47 WBGene00005711 sru-‐48 WBGene00005712 srv-‐1 WBGene00005713 srv-‐2 WBGene00005714 srv-‐3 WBGene00005715 srv-‐4 WBGene00005716 srv-‐5 WBGene00005717 srv-‐6 WBGene00005718 srv-‐7 WBGene00005719 srv-‐8 WBGene00005720 srv-‐9 WBGene00005721 srv-‐10 WBGene00005722 srv-‐11 WBGene00005723 srv-‐12 WBGene00005724 srv-‐13 WBGene00005725 srv-‐14 WBGene00005726 srv-‐15 WBGene00005727 srv-‐16 WBGene00005728 srv-‐17 WBGene00005730 srv-‐19 WBGene00005732 srv-‐21 WBGene00005733 srv-‐22 WBGene00005735 srv-‐24 WBGene00005736 srv-‐25 WBGene00005737 srv-‐26 WBGene00005738 srv-‐27 WBGene00005739 srv-‐28 WBGene00005740 srv-‐29 WBGene00005741 srv-‐30 WBGene00005742 srv-‐31 WBGene00005743 srv-‐32 WBGene00005745 srv-‐34 WBGene00005747 srv-‐36 WBGene00005748 srw-‐1 WBGene00005749 srw-‐2 WBGene00005750 srw-‐3 WBGene00005751 srw-‐4 WBGene00005753 srw-‐6
Nature Immunology: doi:10.1038/ni.2957
WBGene00005754 srw-‐7 WBGene00005755 srw-‐8 WBGene00005756 srw-‐9 WBGene00005757 srw-‐10 WBGene00005758 srw-‐11 WBGene00005759 srw-‐12 WBGene00005760 srw-‐13 WBGene00005761 srw-‐14 WBGene00005762 srw-‐15 WBGene00005763 srw-‐16 WBGene00005764 srw-‐17 WBGene00005766 srw-‐19 WBGene00005767 srw-‐20 WBGene00005768 srw-‐21 WBGene00005769 srw-‐22 WBGene00005770 srw-‐23 WBGene00005771 srw-‐24 WBGene00005773 srw-‐26 WBGene00005776 srw-‐29 WBGene00005777 srw-‐30 WBGene00005778 srw-‐31 WBGene00005779 srw-‐32 WBGene00005780 srw-‐33 WBGene00005781 srw-‐34 WBGene00005782 srw-‐35 WBGene00005783 srw-‐36 WBGene00005785 srw-‐38 WBGene00005786 srw-‐39 WBGene00005787 srw-‐40 WBGene00005788 srw-‐41 WBGene00005789 srw-‐42 WBGene00005790 srw-‐43 WBGene00005791 srw-‐44 WBGene00005795 srw-‐48 WBGene00005798 srw-‐51 WBGene00005800 srw-‐53 WBGene00005801 srw-‐54 WBGene00005802 srw-‐55 WBGene00005803 srw-‐56 WBGene00005804 srw-‐57 WBGene00005805 srw-‐58
Nature Immunology: doi:10.1038/ni.2957
WBGene00005806 srw-‐59 WBGene00005807 srw-‐60 WBGene00005808 srw-‐61 WBGene00005810 srw-‐63 WBGene00005813 srw-‐66 WBGene00005814 srw-‐67 WBGene00005815 srw-‐68 WBGene00005816 srw-‐69 WBGene00005818 srw-‐71 WBGene00005819 srw-‐72 WBGene00005820 srw-‐73 WBGene00005822 srw-‐75 WBGene00005823 srw-‐76 WBGene00005824 srw-‐77 WBGene00005826 srw-‐79 WBGene00005829 srw-‐82 WBGene00005830 srw-‐83 WBGene00005831 srw-‐84 WBGene00005832 srw-‐85 WBGene00005834 srw-‐87 WBGene00005835 srw-‐88 WBGene00005836 srw-‐89 WBGene00005837 srw-‐90 WBGene00005838 srw-‐91 WBGene00005841 srw-‐94 WBGene00005842 srw-‐95 WBGene00005843 srw-‐96 WBGene00005844 srw-‐97 WBGene00005845 srw-‐98 WBGene00005846 srw-‐99 WBGene00005847 srw-‐100 WBGene00005848 srw-‐101 WBGene00005849 srw-‐102 WBGene00005850 srw-‐103 WBGene00005854 srw-‐107 WBGene00005855 srw-‐108 WBGene00005856 srw-‐109 WBGene00005858 srw-‐111 WBGene00005859 srw-‐112 WBGene00005860 srw-‐113 WBGene00005862 srw-‐115
Nature Immunology: doi:10.1038/ni.2957
WBGene00005864 srw-‐117 WBGene00005865 srw-‐118 WBGene00005866 srw-‐119 WBGene00005867 srw-‐120 WBGene00005868 srw-‐121 WBGene00005869 srw-‐122 WBGene00005870 srw-‐123 WBGene00005871 srw-‐124 WBGene00005874 srw-‐127 WBGene00005876 srw-‐129 WBGene00005877 srw-‐130 WBGene00005879 srw-‐132 WBGene00005880 srw-‐133 WBGene00005881 srw-‐134 WBGene00005883 srw-‐136 WBGene00005884 srw-‐137 WBGene00005885 srw-‐138 WBGene00005886 srw-‐139 WBGene00005887 srw-‐140 WBGene00005888 srw-‐141 WBGene00005889 srw-‐142 WBGene00005890 srw-‐143 WBGene00005891 srw-‐144 WBGene00011197 srw-‐145 WBGene00005892 srx-‐1 WBGene00005893 srx-‐2 WBGene00005894 srx-‐3 WBGene00005895 srx-‐4 WBGene00005896 srx-‐5 WBGene00005898 srx-‐7 WBGene00005899 srx-‐8 WBGene00005900 srx-‐9 WBGene00005901 srx-‐10 WBGene00005903 srx-‐12 WBGene00005904 srx-‐13 WBGene00005905 srx-‐14 WBGene00005907 srx-‐16 WBGene00005908 srx-‐17 WBGene00005909 srx-‐18 WBGene00005910 srx-‐19 WBGene00005911 srx-‐20
Nature Immunology: doi:10.1038/ni.2957
WBGene00005912 srx-‐21 WBGene00005913 srx-‐22 WBGene00005914 srx-‐23 WBGene00005917 srx-‐26 WBGene00005919 srx-‐28 WBGene00005920 srx-‐29 WBGene00005922 srx-‐31 WBGene00005923 srx-‐32 WBGene00005924 srx-‐33 WBGene00005925 srx-‐34 WBGene00005926 srx-‐35 WBGene00005927 srx-‐36 WBGene00005929 srx-‐38 WBGene00005930 srx-‐39 WBGene00005932 srx-‐41 WBGene00005933 srx-‐42 WBGene00005934 srx-‐43 WBGene00005935 srx-‐44 WBGene00005936 srx-‐45 WBGene00005937 srx-‐46 WBGene00005938 srx-‐47 WBGene00005939 srx-‐48 WBGene00005941 srx-‐50 WBGene00005942 srx-‐51 WBGene00005944 srx-‐53 WBGene00005945 srx-‐54 WBGene00005946 srx-‐55 WBGene00005947 srx-‐56 WBGene00005949 srx-‐58 WBGene00005950 srx-‐59 WBGene00005951 srx-‐60 WBGene00005953 srx-‐62 WBGene00005954 srx-‐63 WBGene00005955 srx-‐64 WBGene00005956 srx-‐65 WBGene00005957 srx-‐66 WBGene00005958 srx-‐67 WBGene00005959 srx-‐68 WBGene00005964 srx-‐73 WBGene00005965 srx-‐74 WBGene00005967 srx-‐76
Nature Immunology: doi:10.1038/ni.2957
WBGene00005968 srx-‐77 WBGene00005969 srx-‐78 WBGene00005970 srx-‐79 WBGene00005971 srx-‐80 WBGene00005973 srx-‐82 WBGene00005975 srx-‐84 WBGene00005976 srx-‐85 WBGene00005977 srx-‐86 WBGene00005978 srx-‐87 WBGene00005979 srx-‐88 WBGene00005980 srx-‐89 WBGene00005981 srx-‐90 WBGene00005983 srx-‐92 WBGene00005984 srx-‐93 WBGene00005986 srx-‐95 WBGene00005987 srx-‐96 WBGene00005988 srx-‐97 WBGene00005989 srx-‐98 WBGene00005992 srx-‐101 WBGene00005993 srx-‐102 WBGene00005996 srx-‐105 WBGene00005999 srx-‐108 WBGene00006001 srx-‐110 WBGene00006002 srx-‐111 WBGene00006003 srx-‐112 WBGene00006004 srx-‐113 WBGene00006005 srx-‐114 WBGene00006006 srx-‐115 WBGene00006007 srx-‐116 WBGene00006008 srx-‐117 WBGene00006009 srx-‐118 WBGene00006010 srx-‐119 WBGene00006011 srx-‐120 WBGene00006012 srx-‐121 WBGene00006013 srx-‐122 WBGene00006016 srx-‐125 WBGene00006019 srx-‐128 WBGene00006020 srx-‐129 WBGene00006021 srx-‐130 WBGene00006022 srx-‐131 WBGene00006024 srx-‐133
Nature Immunology: doi:10.1038/ni.2957
WBGene00006025 srx-‐134 WBGene00006026 srx-‐135 WBGene00006027 srx-‐136 WBGene00006028 srx-‐137 WBGene00012318 srxa-‐1 WBGene00010153 srxa-‐2 WBGene00017564 srxa-‐4 WBGene00015637 srxa-‐5 WBGene00012321 srxa-‐6 WBGene00007834 srxa-‐7 WBGene00011013 srxa-‐8 WBGene00014070 srxa-‐9 WBGene00011219 srxa-‐10 WBGene00044114 srxa-‐11 WBGene00044115 srxa-‐12 WBGene00044116 srxa-‐13 WBGene00012846 srxa-‐14 WBGene00012847 srxa-‐15 WBGene00009707 srxa-‐16 WBGene00007432 srxa-‐18 WBGene00044012 srxa-‐19 WBGene00008814 srz-‐1 WBGene00023411 srz-‐3 WBGene00015175 srz-‐4 WBGene00021722 srz-‐5 WBGene00011876 srz-‐6 WBGene00022483 srz-‐8 WBGene00022481 srz-‐9 WBGene00014195 srz-‐10 WBGene00023506 srz-‐11 WBGene00010688 srz-‐12 WBGene00010590 srz-‐13 WBGene00010588 srz-‐14 WBGene00007865 srz-‐15 WBGene00008947 srz-‐16 WBGene00009763 srz-‐18 WBGene00018972 srz-‐19 WBGene00018973 srz-‐20 WBGene00019051 srz-‐23 WBGene00017113 srz-‐24 WBGene00014679 srz-‐25
Nature Immunology: doi:10.1038/ni.2957
WBGene00021182 srz-‐28 WBGene00007456 srz-‐29 WBGene00010389 srz-‐31 WBGene00021033 srz-‐32 WBGene00023474 srz-‐37 WBGene00023508 srz-‐38 WBGene00010388 srz-‐42 WBGene00008328 srz-‐43 WBGene00008327 srz-‐44 WBGene00013466 srz-‐47 WBGene00008981 srz-‐48 WBGene00013625 srz-‐53 WBGene00013626 srz-‐54 WBGene00016519 srz-‐56 WBGene00009298 srz-‐58 WBGene00015411 srz-‐60 WBGene00010530 srz-‐61 WBGene00023478 srz-‐62 WBGene00023499 srz-‐63 WBGene00021970 srz-‐64 WBGene00009569 srz-‐66 WBGene00023479 srz-‐67 WBGene00015656 srz-‐70 WBGene00023513 srz-‐71 WBGene00023514 srz-‐72 WBGene00010527 srz-‐74 WBGene00023517 srz-‐75 WBGene00023518 srz-‐76 WBGene00015653 srz-‐78 WBGene00015652 srz-‐79 WBGene00023463 srz-‐82 WBGene00023462 srz-‐83 WBGene00015018 srz-‐85 WBGene00007678 srz-‐90 WBGene00012406 srz-‐91 WBGene00009912 srz-‐94 WBGene00013629 srz-‐95 WBGene00013468 srz-‐96 WBGene00023515 srz-‐97 WBGene00012028 srz-‐99 WBGene00012026 srz-‐100
Nature Immunology: doi:10.1038/ni.2957
WBGene00008818 srz-‐101 WBGene00023505 srz-‐102 WBGene00008815 srz-‐103 WBGene00044587 srz-‐105 WBGene00006069 str-‐1 WBGene00006070 str-‐2 WBGene00006071 str-‐3 WBGene00006072 str-‐4 WBGene00006073 str-‐5 WBGene00006074 str-‐6 WBGene00006075 str-‐7 WBGene00006076 str-‐8 WBGene00006077 str-‐9 WBGene00006078 str-‐10 WBGene00006080 str-‐12 WBGene00006081 str-‐13 WBGene00006082 str-‐14 WBGene00006083 str-‐15 WBGene00006084 str-‐16 WBGene00006085 str-‐18 WBGene00006086 str-‐19 WBGene00006087 str-‐20 WBGene00006090 str-‐23 WBGene00006092 str-‐25 WBGene00006093 str-‐27 WBGene00006094 str-‐28 WBGene00006096 str-‐30 WBGene00006097 str-‐31 WBGene00006098 str-‐32 WBGene00006099 str-‐33 WBGene00006102 str-‐37 WBGene00006103 str-‐38 WBGene00006104 str-‐39 WBGene00006105 str-‐40 WBGene00006106 str-‐41 WBGene00006108 str-‐43 WBGene00006109 str-‐44 WBGene00006110 str-‐45 WBGene00006111 str-‐46 WBGene00006112 str-‐47 WBGene00006113 str-‐48
Nature Immunology: doi:10.1038/ni.2957
WBGene00006117 str-‐52 WBGene00006120 str-‐55 WBGene00006121 str-‐56 WBGene00006122 str-‐57 WBGene00006124 str-‐60 WBGene00006125 str-‐61 WBGene00006126 str-‐63 WBGene00006127 str-‐64 WBGene00006128 str-‐66 WBGene00006129 str-‐67 WBGene00006130 str-‐68 WBGene00006131 str-‐69 WBGene00006133 str-‐71 WBGene00006134 str-‐73 WBGene00006135 str-‐74 WBGene00006136 str-‐76 WBGene00006137 str-‐77 WBGene00006138 str-‐78 WBGene00006139 str-‐79 WBGene00006140 str-‐81 WBGene00006141 str-‐82 WBGene00006142 str-‐83 WBGene00006143 str-‐84 WBGene00006144 str-‐85 WBGene00006145 str-‐86 WBGene00006146 str-‐87 WBGene00006147 str-‐88 WBGene00006148 str-‐89 WBGene00006149 str-‐90 WBGene00006150 str-‐92 WBGene00006151 str-‐93 WBGene00006152 str-‐94 WBGene00006153 str-‐96 WBGene00006154 str-‐97 WBGene00006155 str-‐99 WBGene00006156 str-‐101 WBGene00006157 str-‐102 WBGene00006158 str-‐103 WBGene00006159 str-‐106 WBGene00006160 str-‐108 WBGene00006161 str-‐109
Nature Immunology: doi:10.1038/ni.2957
WBGene00006162 str-‐111 WBGene00006163 str-‐112 WBGene00006164 str-‐113 WBGene00006165 str-‐114 WBGene00006166 str-‐115 WBGene00006167 str-‐116 WBGene00006169 str-‐118 WBGene00006170 str-‐119 WBGene00006171 str-‐120 WBGene00006172 str-‐121 WBGene00006173 str-‐122 WBGene00006174 str-‐123 WBGene00006175 str-‐124 WBGene00006176 str-‐125 WBGene00006178 str-‐129 WBGene00006179 str-‐130 WBGene00006180 str-‐131 WBGene00006182 str-‐134 WBGene00006183 str-‐135 WBGene00006184 str-‐136 WBGene00006187 str-‐138 WBGene00006186 str-‐139 WBGene00006188 str-‐140 WBGene00006189 str-‐141 WBGene00006190 str-‐143 WBGene00006191 str-‐144 WBGene00006192 str-‐145 WBGene00006193 str-‐146 WBGene00006195 str-‐148 WBGene00006196 str-‐149 WBGene00006197 str-‐150 WBGene00006198 str-‐151 WBGene00006199 str-‐153 WBGene00006200 str-‐154 WBGene00006201 str-‐155 WBGene00006202 str-‐156 WBGene00006203 str-‐158 WBGene00006204 str-‐159 WBGene00006205 str-‐160 WBGene00006206 str-‐161 WBGene00006207 str-‐162
Nature Immunology: doi:10.1038/ni.2957
WBGene00006208 str-‐163 WBGene00006209 str-‐164 WBGene00006210 str-‐165 WBGene00006211 str-‐166 WBGene00006212 str-‐168 WBGene00006213 str-‐169 WBGene00006214 str-‐170 WBGene00006215 str-‐171 WBGene00006216 str-‐172 WBGene00006217 str-‐173 WBGene00006218 str-‐174 WBGene00006219 str-‐175 WBGene00006221 str-‐177 WBGene00006222 str-‐178 WBGene00006224 str-‐180 WBGene00006225 str-‐181 WBGene00006227 str-‐183 WBGene00006228 str-‐185 WBGene00006229 str-‐187 WBGene00006230 str-‐188 WBGene00006231 str-‐190 WBGene00006232 str-‐193 WBGene00006233 str-‐196 WBGene00006234 str-‐198 WBGene00006237 str-‐204 WBGene00006238 str-‐205 WBGene00006239 str-‐206 WBGene00006240 str-‐207 WBGene00006241 str-‐208 WBGene00006242 str-‐209 WBGene00006244 str-‐211 WBGene00006247 str-‐214 WBGene00006249 str-‐217 WBGene00006251 str-‐220 WBGene00006252 str-‐221 WBGene00006253 str-‐222 WBGene00006254 str-‐223 WBGene00006255 str-‐224 WBGene00006256 str-‐225 WBGene00006257 str-‐226 WBGene00006258 str-‐227
Nature Immunology: doi:10.1038/ni.2957
WBGene00006259 str-‐228 WBGene00006260 str-‐229 WBGene00006261 str-‐230 WBGene00006262 str-‐231 WBGene00006263 str-‐232 WBGene00006264 str-‐233 WBGene00006265 str-‐236 WBGene00006266 str-‐238 WBGene00006268 str-‐240 WBGene00006270 str-‐243 WBGene00006271 str-‐244 WBGene00006272 str-‐245 WBGene00006273 str-‐246 WBGene00006274 str-‐247 WBGene00006275 str-‐248 WBGene00006277 str-‐250 WBGene00006278 str-‐252 WBGene00006279 str-‐253 WBGene00006280 str-‐254 WBGene00006281 str-‐255 WBGene00006282 str-‐256 WBGene00006283 str-‐257 WBGene00006284 str-‐258 WBGene00006286 str-‐260 WBGene00006287 str-‐261 WBGene00006288 str-‐262 WBGene00006289 str-‐263 WBGene00007370 str-‐264 WBGene00021228 str-‐265 WBGene00018915 str-‐267 WBGene00006428 tag-‐49 WBGene00006459 tag-‐89 WBGene00015398 tag-‐293 WBGene00006576 tkr-‐1 WBGene00017157 tyra-‐2 WBGene00006475 tyra-‐3 WBGene00014998 AH9.1 WBGene00015000 AH9.4 WBGene00015005 B0034.5 WBGene00015081 B0244.6 WBGene00015082 B0244.7
Nature Immunology: doi:10.1038/ni.2957
WBGene00007146 B0334.6 WBGene00007161 B0391.3 WBGene00015263 B0563.6 WBGene00015299 C01F1.4 WBGene00015409 C03H5.7 WBGene00015416 C04C3.6 WBGene00015417 C04C3.7 WBGene00007360 C06B3.1 WBGene00007379 C06C6.1 WBGene00007395 C06H5.7 WBGene00007483 C09F12.3 WBGene00007528 C11H1.2 WBGene00007595 C15A7.2 WBGene00015799 C15H9.3 WBGene00007635 C16D6.2 WBGene00015921 C17H11.1 WBGene00007664 C18B12.2 WBGene00044004 C24A8.6 WBGene00016044 C24B5.1 WBGene00016089 C25B8.5 WBGene00016090 C25B8.7 WBGene00045413 C25F9.13 WBGene00016149 C26F1.6 WBGene00016222 C29F9.8 WBGene00016223 C29F9.9 WBGene00016246 C30B5.5 WBGene00016248 C30B5.7 WBGene00044179 C30G7.5 WBGene00007842 C31E10.1 WBGene00007908 C34B4.3 WBGene00016428 C35A11.1 WBGene00007951 C35A5.7 WBGene00008021 C39B10.1 WBGene00008060 C41G6.16 WBGene00008079 C44B9.2 WBGene00044087 C45H4.18 WBGene00016708 C46E10.2 WBGene00016761 C49A9.7 WBGene00016842 C50F7.1 WBGene00016858 C50H11.13 WBGene00016909 C54A12.2
Nature Immunology: doi:10.1038/ni.2957
WBGene00008308 C54E10.3 WBGene00008321 C55A1.1 WBGene00008329 C55A1.15 WBGene00008342 C56A3.3 WBGene00016984 C56G3.1 WBGene00017015 D1014.2 WBGene00017038 D1069.4 WBGene00014300 D2023.1 WBGene00008481 E04D5.2 WBGene00008550 F07B10.4 WBGene00077514 F07B10.7 WBGene00017278 F09C12.6 WBGene00077493 F09C6.16 WBGene00008637 F10A3.12 WBGene00008638 F10A3.16 WBGene00008635 F10A3.7 WBGene00017338 F10D7.1 WBGene00008808 F14F4.1 WBGene00008885 F16C3.1 WBGene00017566 F18E3.10 WBGene00017661 F21C10.12 WBGene00009046 F22B8.3 WBGene00017779 F25E2.1 WBGene00009194 F27E5.5 WBGene00044027 F27E5.8 WBGene00009278 F31B9.1 WBGene00009333 F32D8.10 WBGene00018067 F35G8.1 WBGene00018073 F35H10.10 WBGene00018089 F36D4.4 WBGene00018179 F38E1.6 WBGene00009558 F39B2.8 WBGene00018191 F39B3.2 WBGene00018222 F40A3.7 WBGene00077531 F40G9.15 WBGene00009619 F41E7.3 WBGene00018312 F41H8.1 WBGene00018313 F41H8.2 WBGene00018344 F42C5.2 WBGene00044031 F49C5.9 WBGene00009931 F52D10.4
Nature Immunology: doi:10.1038/ni.2957
WBGene00018728 F53A9.5 WBGene00009965 F53B7.2 WBGene00010058 F54E4.2 WBGene00018886 F55E10.7 WBGene00010179 F57A8.4 WBGene00010191 F57B7.1 WBGene00019012 F57C9.6 WBGene00044048 F57G9.7 WBGene00019019 F57H12.4 WBGene00019098 F59B1.4 WBGene00019099 F59B1.6 WBGene00010315 F59B2.13 WBGene00010329 F59D12.1 WBGene00010375 H09F14.1 WBGene00019183 H10E21.2 WBGene00019231 H23L24.4 WBGene00019262 H34P18.1 WBGene00010442 JC8.12 WBGene00019287 K01A12.3 WBGene00010448 K01A6.6 WBGene00045100 K03D3.14 WBGene00019367 K03H6.1 WBGene00019370 K03H6.5 WBGene00010591 K05D4.9 WBGene00019448 K06C4.17 WBGene00019444 K06C4.8 WBGene00019445 K06C4.9 WBGene00019496 K07E8.5 WBGene00010634 K07F5.6 WBGene00019518 K08B5.1 WBGene00019523 K08D9.1 WBGene00019560 K09C6.6 WBGene00010735 K10C8.2 WBGene00019625 K10C9.4 WBGene00077679 K11E4.6 WBGene00010820 M01G12.6 WBGene00189957 M03F8.7 WBGene00010979 R02D5.6 WBGene00020086 R106.2 WBGene00011211 R10E8.5 WBGene00020008 R11F4.2
Nature Immunology: doi:10.1038/ni.2957
WBGene00044045 R11G10.3 WBGene00020023 R12C12.3 WBGene00194726 R13A5.15 WBGene00020056 R13D11.1 WBGene00020057 R13D11.3 WBGene00020069 R13H7.2 WBGene00011341 T01G5.6 WBGene00011372 T02D1.6 WBGene00011381 T02E9.1 WBGene00011395 T03E6.2 WBGene00011397 T03E6.8 WBGene00045356 T03E6.9 WBGene00011441 T04F8.2 WBGene00011518 T06C12.11 WBGene00011534 T06E4.7 WBGene00011582 T07D10.2 WBGene00020319 T07F8.2 WBGene00011686 T10C6.2 WBGene00020420 T10E10.3 WBGene00011693 T10G3.2 WBGene00011695 T10G3.4 WBGene00020424 T10H9.1 WBGene00011709 T11F9.1 WBGene00011728 T12A7.7 WBGene00011765 T14C1.1 WBGene00020523 T15B7.11 WBGene00020524 T15B7.12 WBGene00020525 T15B7.13 WBGene00020586 T19F4.1 WBGene00011878 T21B4.4 WBGene00011922 T22C8.1 WBGene00020727 T23C6.5 WBGene00011947 T23F1.3 WBGene00012072 T26H8.4 WBGene00077588 T26H8.5 WBGene00194821 T27B2.1 WBGene00012089 T27E7.4 WBGene00012090 T27E7.5 WBGene00012093 T27E7.9 WBGene00012147 VC27A7L.1 WBGene00194896 W02H5.11
Nature Immunology: doi:10.1038/ni.2957
WBGene00012283 W05H5.1 WBGene00012349 W08G11.5 WBGene00021124 W10C4.1 WBGene00013645 Y105C5B.1 WBGene00013782 Y116A8B.5 WBGene00021216 Y19D10A.1 WBGene00021217 Y19D10A.2 WBGene00021275 Y23H5B.4 WBGene00045303 Y27F2A.10 WBGene00045304 Y27F2A.11 WBGene00021310 Y32H12A.1 WBGene00021328 Y34D9A.2 WBGene00012575 Y37H2C.4 WBGene00021490 Y40B10A.5 WBGene00021510 Y41D4A.8 WBGene00021524 Y41D4B.24 WBGene00021573 Y45G12C.10 WBGene00021569 Y45G12C.6 WBGene00012939 Y47D3B.1 WBGene00012962 Y48A6B.1 WBGene00012993 Y48C3A.11 WBGene00013187 Y54E2A.1 WBGene00013222 Y54G11B.1 WBGene00043061 Y54G2A.38 WBGene00044460 Y55F3C.10 WBGene00013288 Y57A10C.10 WBGene00013286 Y57A10C.8 WBGene00013335 Y57G11C.46 WBGene00021983 Y58G8A.4 WBGene00021984 Y59C2A.1 WBGene00022004 Y59H11AL.1 WBGene00013389 Y62H9A.1 WBGene00013398 Y62H9A.10 WBGene00012397 Y6E2A.1 WBGene00013490 Y70C5A.2 WBGene00077464 Y70C5B.2 WBGene00013496 Y70D2A.1 WBGene00013572 Y75B12B.10 WBGene00013551 Y75B8A.16 WBGene00044464 Y77E11A.16 WBGene00021184 Y9C9A.17
Nature Immunology: doi:10.1038/ni.2957
WBGene00021177 Y9C9A.5 WBGene00021178 Y9C9A.8 WBGene00022522 ZC132.3 WBGene00022527 ZC132.9 WBGene00022604 ZC404.10 WBGene00022605 ZC404.11 WBGene00022606 ZC404.13 WBGene00077562 ZC443.7 WBGene00013848 ZC84.4 WBGene00044551 ZK105.8 WBGene00014248 ZK1307.7 WBGene00022735 ZK418.6 WBGene00022736 ZK418.7 WBGene00014035 ZK643.3 WBGene00022811 ZK721.4 WBGene00022824 ZK813.5 a Gene identifiers from WS220.
b Genes targeted by one or more RNAi clone are highlighted in green
Notes:
(i) Some gene families were incompletely annotated and non-‐contiguously named in
the WS220 release. For example, there were only 15 named members of the npr
family. In release WS230, there were 20 members, npr-‐1 to npr-‐20. By WS232, the
number had increased to 33 (npr-‐1 to npr-‐33).
(ii) Some gene families are non-‐contiguously named in this list for other reasons. For
example, srab-‐5 is predicted to be a pseudogene, so is not included in the list.
(iii) Some gene families were incompletely annotated with regards INTERPRO
domains in the WS220 release. For example, srab-‐8 encodes a protein with the
Nature Immunology: doi:10.1038/ni.2957
INTERPRO:IPR019408 (7TM_GPCR_serpentine_rcpt_Srab) domain but this
information is not in Wormbase release WS220.
(iv) The public gene names dcar-‐1 and frpr-‐11 do not appear in the table as they were
assigned to WBGene00007395 and WBGene00019444, respectively, subsequent to
the release WS220.
Nature Immunology: doi:10.1038/ni.2957
