Nathan Blum - Evaluation of the PROMIS Pediatric Parent-Proxy Peer Relationships Measure in Children with Autism Spectrum Disorder: A Developmental-Behavioral Pediatrics Research Network

Methods Abstract Objectives Results Conclusions References 1. DeWalt, D.A., Thiseen, D., Stucky , B.D., et al. (2013).. PROMIS Pediatric Peer Relationships Scale: Development of a Peer Relationship s Item Bank as Part of Social Health Measurement. Healthy Psychology , 32 (10), 1093-1103. 2. Orsmond, G.I. , Krauss, M.W., and Seltzer , M.M. (2004). Peer Relation ships and So cial and Recreational Activities Among Adolescents and Adults with Autism. Journal of Autism and Developmenta l Disorders 34 (3), 245-256. 3. Walton, K.M. and In gersoll, B.R. (2013). Improving Social Skills in Adolesce nts and Adult s with Autism and Severe to Profound Intellectua l Disability: A Review of the Literatur e. Journal of Autism and Developmental Disorders 4 3 (3), 594-615. Aim: Evaluate the validity of the PROMIS pediatric parent-proxy Peer Relationships measure in 5- 12 year old children with ASD. • Objective 1: Determine whether the PROMIS measure assesses the full range of the trait with acceptable precision in 5-12 year old children with ASD. • Objective 1.2: Determine whether ASD-specific symptom severity and IQ are associated with scores on the PROMIS measure in the manner predicted based on existing literature. • Hypotheses: Higher scores on the PROMIS measure will be inversely associated with ASD severity and positively associated with IQ. Background: The NIH Patient Reported Outcome Measurement Information System (PROMIS) initiative has developed a freely available measure of peer relationships that can be administered efficiently using computerized adaptive testing (CAT). The PROMIS pediatric parent-proxy Peer Relationships measure has not been evaluated in children with Autism Spectrum D isorder (ASD). Objective: To evaluate the PROMIS pediatric parent-proxy Peer Relationships measure in 5-12 year old children with ASD. Design/Methods: Participants were parents of 5-12 year old children with ASD at one of three participating Developme ntal-Behaviora l Pediatrics Research Network (DBPNet) sites. These parents completed a demographic form, the pediatric parent-proxy Peer Relationships measure, and the Social Responsiveness Scale 2 nd Edition (SRS-2), a standardized measure of social skills concerns. The Peer Relationships measure was completed using CAT, minimizing the number of items administered while maintaining measurement precision. Results: Ninety-seven parents participated in the study. The mean age of the children was 8 years (SD 2.0), 89 percent were male, and mean IQ was 85 (range: 39-138). The SRS-2 Total T-score mean was elevated (76, SD 11). The CAT required just 5 items in 95 of the 97 participants to achieve adequate levels of precision (equivalent to a reliability coefficient of >0.90). The T-scores for the Peer Relationships measure were normally distributed but shifted to the left. The mean T-score was 35.7 (SD 7), which was approximately 1.5 SD below the mean in the measure’s original standardization sample. There was a moderately strong negative correlation between the Peer Relationships measure and the SRS-2 total score (r=-0.58, p<0.001) and a mildly strong positive correlations between the measure and the child’s IQ (r = 0.23, p <0.03). Conclusions: The PROMIS parent-proxy pediatric Peer Relationships measure may be an efficient, precise, and valid measure of peer relationships in 5-12 year old children with ASD. PROMIS pediatric parent-proxy Peer Relationships measure may be an efficient, precise, valid measure of peer relationships in 5-12 year old children with ASD. Recruitment Population: • Site registries (including the Autism Treatment Network at The Children’s Hospital of Philadelphia) • Electronic medical record screen • Developmental-Behavioral Pediatrics clinics Inclusion Criteria: • ASD diagno sis confirmed by DSM criteria and either Autism Diagnostic Observation Schedule (ADOS) or Childhood Autism Rating Scale (CARS) • IQ test or global developmental assessment performed at > 48 months of age • Parental fluency in English or Spanish Exclusion Criteria: • IQ <25 • Moderate or severe hearing loss • Moderate or severe vision impairment Forms completed on Assessment Center: • Consent Form • Demographic Form • Pediatric parent-proxy Peer Relationships measure (via CAT) • SRS-2 • Parenting Stress Index Short Form (PSI-SF) • PROMIS self-report Depression measure Printed by Evaluation of the PROMIS Pediatric Parent-Proxy Peer Relationships Measure in Children with Autism Spectrum Disorder: A Developmental-Beha vioral Pediatrics Research Network Study Marisa Toomey, MD 1 , Justin Schwartz, MD 4 , Michele Laverdiere, MD 6 , Carolyn Bridgemohan, MD 4,5 , Noelle Huntington, PhD 4,5 , Ruth Stein, MD 6,7 , Ellen Silver, PhD 6,7 , Carole Tucker, PT, PhD 2,3 , Katherine Bevans, PhD 1,2 , Christopher B. Forrest, MD, PhD 1,2 and Nathan J. Blum, MD 1,2 . 1 The Children's Hospital of Philadelphia, Philadelphia, PA; 2 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; 3 Temple University, Philadelphia, PA; 4 Boston Children's Hospital, Boston, MA; 5 Harvard Medical School, Boston, MA; 6 Children's Hospital at Montefiore, Bronx, NY; 7 Albert Einstein College of Medicine, Bronx, NY Demographics N = 97 Mean or % SD or Range Child Age 8 2 Percent Male 89% Race • Caucasian 69% • Non-Caucasian 31% Ethnicity • Non-Hispanic 73% • Hispanic 23% IQ 85 39-138 SRS Total T Score 76 11 Parent Education Level 66% college or higher SRS-2 Total T Score IQ Peer Relationships T Score r: -0.58 p<0.0001 r: 0.23 p<0.03 Mean T score: 35.7 SD: 7.0 • Moderate negative correlation with SRS-2 Total T score • Mild positive correlation with IQ

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Nathan Blum - Evaluation of the PROMIS Pediatric Parent-Proxy Peer Relationships Measure in Children with Autism Spectrum Disorder: A Developmental-Behavioral Pediatrics Research Network