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NanoRelease Food AdditiveSupporting Methods to Measure Food Nanomaterials
Webinar to present Task Group White PapersApril 16 , 2013
www.riskscience.org
What is the issue being addressed?
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Nanopowder
Dissolved constituents (no longer nano?)
Engineered nanomaterials (ENM) used/being developed for food, beverages, supplements to:- increase nutrition- increase food safety (packaging, shelf life)- change physical/chemical properties
Some “traditional” processed food components are nano too. Where do we focus the science to address potential risk?
Methods to measure what nano characteristics affect absorption as nanoparticles into the body would greatly clarify where to focus attention.
About the project
OFFICIAL CHARGE: “Identify, evaluate, and develop methods needed to confidently detect, characterize and evaluate intentionally produced nanoparticles released from food along the alimentary tract, as occurring through direct food additives or indirect incorporation in food through migration from food contact materials or environmental contamination.”
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• 70+ multi-stakeholder experts collaborating for methods development for oral exposure to ENM
• GOAL: Develop methods that distinguish which nanomaterials do and do not persist to absorption from food.
thus provide data that help clarify risk thus allow safer, sustainable improvements
Benefits of the project• Continuous technical dialogue internationally across
key stakeholder experts about safe development of food nanotech
• Public-private partnership allows balance of views from academia, industry, government, public interest organizations
• Secretariat (ILSI Research Foundation) facilitates collaboration without backing any particular stakeholder view.
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Organization within project
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Steering Committee
(SC)
TG1 Material Characteristics
TG2 Alimentary Canal
Environment
TG3 Alimentary Canal Models
TG4 Measurement
Methods
TG5 Risk Management
Aspects
Interlaboratory Testing Group
(ITG)
State of the Science Team
(SOST)
Collect and analyze information relevant to methods development
Top level view of the state of the science and context.
Develop and implement workplans to improve methods.
Develop charges and decide scope (e.g., what methods to improve)
Steering Committee
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• COCHAIR Annette McCarthy (US FDA)
• COCHAIR Steve Roberts (Univ. of Florida)
• Timothy Duncan, Scott Thurmond, Gregory Noonan (FDA)
• Thomas Neltner (Pew Charitable Trusts)
• Andrew Maynard (Univ. of Michigan)• Joseph Scimeca (Cargill, ILSI NA)• David Carlander (Nanotechnology
Industries Association)• Francois Rossi (European
Commission)• Stephane Vidry, Alessandro Chiodini
(ILSI Europe)• Danielle Fugere (As You Sow)
• Robert Brackett (Institute for Food Safety & Health)
• Shaun Clancy (Evonik Degussa)• Carolyn Cairns, Michael Hansen
(Consumers Union)• Neil Buck (DSM, ILSI Europe)• Stefan Weigel (RIKILT – Institute of
Food Safety)• Abdul Afghan, Don Forsyth, Andrew
Atkinson, David Lefebvre, Mark Perry, Rekha Mehta (Health Canada)
• Rickey Yada (Univ of Guelph)• Vicki Stone (Heriot Watt Univ.)• Eva Maria Collnot (Saarland Univ.)• John Milner (USDA)• Susann Bellman (TNO Netherlands)
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TIMELINEJan-May 2012SC gathered, establishes goal,
scope, & focuses of TGsJune-Sept 2012
TGs gathered, finalize charges, collect and evaluate info
2013-2014Methods development
(interlaboratory round robin)
Mid 2013TGs & SOST submit for publication,
ITG & SC review information and decide on workplan(s)
Sept 2012 - NowTGs draft and finalize white
papers. SOST gathered, follows TG progress & drafts review article
Sept 2012 PROJECT
WEBINAR
Dec 2012 WORKSHOP
Washington, DC
Jan 2013 SOST
MEETINGMiami, FL
April 2013
PROJECTWEBINAR
SOSTState of the Science Team is an experienced, balanced multi-
stakeholder set of experts who are writing a “state of the science” report on: What do we know and need to know to measure and understand the likelihood of nanomaterial uptake by the body?
Andrew Bartholomaeus U. of Canberra & U. of Queensland
Christopher Szakal US National Inst. of Standards & Technology
Ian Illuminato Friends of Earth
John Milner Human Nutrition Research Ctr. (USDA)
Michael Rogers Rutgers University
Neil Buck DSM Nutritional Products
Paul Westerhoff Arizona State University
Steve Roberts University of Florida
Andrew Cockburn (peer review) University of Newcastle
Paul Howard (peer review) US Food and Drug Admin.
ITGINTERLABORATORY TESTING GROUP
• Lab research experts currently being gathered
• OBJECTIVE: Develop or investigate standardization of existing methodologies (adaptation and validation) with any necessary modifications
• Interlaboratory work plans will improve/develop methods for understanding uptake, using (-) and (+) controls and selected ENM in modeled GI conditions
• ULTIMATE GOAL: promote standardization or scientific consensus on practical methods for evaluating potential uptake of ENM from alimentary canal
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Goal for this webinar• Present high point findings of
the task groups
• Inform the State of the Science team as they prepare their summary
• Seek input from stakeholders
• Inform the Steering Committee as they select methods to carry forward
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Suggested topics for feedbackPlease note that the project goal is to GOAL: Develop methods that distinguish which nanomaterials do and do not persist to absorption from food.
thus provide data that help clarify risk thus allow safer, sustainable improvements
For example, please help us inform the Steering Committee in their task to - Cover what needs to be covered to prepare to address this goal- Narrow scope to practical and near-term methods improvement- Select methods improvements to address- Identify how to improve the methods- Identify synergies and partnerships
Thank youRichard Canady, PhD
Libby Tsytsikova, BS
Secretariat for
Center for Risk Science Innovation and Application (RSIA)
ILSI Research Foundation
1156 Fifteenth ST. NW, Suite 200
Washington DC 20005-1743
Tel: +1-202-659-3306 ext153
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