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Page 1: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,
Page 2: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

Hangzhou Gallop Biological Products Co., Ltd., from 1995, manufactures high-quality products based on non-animal hyaluronic acid, which is used in aesthetic medicine, ophthalmology, gynecology, urology, and orthopedics.

Quality and safety of use of all products are constantly monitored. The company is certified according to international medical and healthcare standards and has the following international certifications: ISO 9001, ISO 13485, CE. Availability of  international certificates confirms the high standards of production of medical products and the highest level of produced medicines.

HAFILLER® is distributed in more than 28 countries around the world and, by 2014, more than 2,150,000 pre-filled syringes have been produced and used worldwide.

In 2014, the company was acquired by Zhejiang Jingjia Medical Technology Co.

ABOUT THE PRODUCER

Page 3: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® is a range of medical hyaluronic acid facial fillers and is used in following treatments: > wrinkle and crease filling, > face modelling, > lip filling and modelling, > body modelling (breasts, buttocks), > hand modelling and rejuvenation.

Page 4: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

What are advantages of HAFILLER®? > The widest range of products for contouring, consisting of 5 fillers, which will meet your every need. > Products have all clinical, toxicological, technical testings and certifications. > Absolute biocompatibility with the human body. > The duration of effect (from 6 to 24 months). > Homogeneous distribution in tissues. > High level of patient's satisfaction after the procedure. > Minor trauma during the manipulation. > Non-animal origin, no skin tests needed. > Fully biodegradable. > Natural effects.

Page 5: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® SUB SKIN Presentation: 2 ml Therapeutic indications and application field: SUB SKIN is designed to form volume, correct contours of a face, improve volume of cheeks and chin, restore, and change of nasal contour. It is used to compensate for the loss of volume during skin aging. The method of administration: HAFILLER® SUB SKIN is injected into deep dermis or subcutaneous tissue. Needle: 23G Expected duration: 9 to 24 months Concentration: 20 mg/ml cross-linked hyaluronic acid The number of gel particles for 1ml: approx. 500 Particle size (mm): 1.25-2.0

Page 6: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® FINE LINES Presentation: 1 ml and 2 ml Therapeutic indications and application field: FINE LINES is used in the correction of very thin wrinkles, eye-around wrinkles, glabellar wrinkles, „crow’s feet” and lines around the mouth. The method of administration: HAFILLER® FINE LINES is injected into the dermis surface layer that needs to be corrected. Needle: 30G Expected duration: 6 to 12 months Concentration: 20 mg/ml cross-linked hyaluronic acid The number of gel particles for 1ml: approx. 300 000 Particle size (mm): 0.1-0.15

Page 7: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® DERM Presentation: 1 ml and 2 ml Therapeutic indications and application field: DERM is used in the moderation of medium wrinkles (ex. lion wrinkles), in the correction of skin folds and in lips shaping. The method of administration: HAFILLER® DERM is injected into the middle dermis. Needle: 30G Expected duration: 6 to 12 months Concentration: 20 mg/ml cross-linked hyaluronic acid The number of gel particles for 1ml: approx. 100 000 Particle size (mm): 0.15-0.28

Page 8: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® DERM PLUS Presentation: 1.5 ml Therapeutic indications and application field: DERM PLUS is designed to fill deep wrinkles, recover and form volume of cheeks, cheekbones, and chin. The method of administration: HAFILLER® DERM DEEP is injected into the deeper layers of the dermis. Needle: 27G Expected duration: 6 to 24 months Concentration: 20 mg/ml cross-linked hyaluronic acid The number of gel particles for 1ml: approx. 5 000 Particle size (mm): 0.5-1.25

Page 9: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® DERM DEEP Presentation: 1 ml and 2 ml Therapeutic indications and application field: DERM DEEP is used in the correction of deep wrinkles and face folds, such as nasolabial furrows as well as in chin and lips enhancement and in the shaping of facial contours. The method of administration: HAFILLER® DERM DEEP is injected into the deeper layers of the dermis. Needle: 27G Expected duration: 6 to 12 months Concentration: 20 mg/ml cross-linked hyaluronic acid The number of gel particles for 1ml: approx. 10 000 Particle size (mm): 0.28-0.5

Page 10: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,
Page 11: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® is an injectable gel based on stabilized hyaluronic acid of non-animal origin. After gel injection, wrinkles are smoothed out, facial contours become clear and a patient gains a younger, healthy look. The effect lasts for at least 6 months.

Hyaluronic acid in HAFILLER® fillers is produced through biofermentation and is applied for intradermal injection in the facial area, for rejuvenation of any skin areas, as well as the correction of age-related changes. Hyaluronic acid degradation is performed enzymatically with the use of endogenous enzyme hyaluronidase.

The structure of hyaluronic acid contained in HAFILLER® fillers is identical to the one of hyaluronic acid in the body. Therefore HAFILLER® fillers are biocompatible with the human body and do not cause an adverse reaction. Exceptions are contraindications for the manipulation.

NATURAL, SAFE AND LONG LASTING

Page 12: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® is injected into skin tissue to restore the extracellular matrix and hydration due to hydrophilic properties of hyaluronic acid. This results in the restoration of skin elasticity and firmness. Small wrinkles are smoothed away and  skin looks younger. What is more, hyaluronic acid has the ability to stimulate collagen synthesis, and to bind free radicals, slowing the ageing of skin

HAFILLER® is crosslinked by adding a minimum amount of BDDE. BDDE ensures homogeneity of the gel particles.

HAFILLER® preparations are designed for aesthetic medicine as a dermal filler for soft-tissue augmentation, filling and smoothing of skin defects (in the standard and unconventional areas), deep wrinkles, hypotrophic scars of various origins, correction of involutory skin aging.

HAFILLER® provides natural look by restoring your skin's volume, creating softness and firmness.

HOW HAFILLER® WORKS?

Page 13: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® is a full range of products created to be able to adapt to different levels of tissue structures.

Hyaluronic acid is known to have an amazing water-binding capacity, making it  ideal for skin hydration. Cross-linked HA has a hundred times the water-binding capacity than natural HA. That means skin is continuously hydrated, plump and healthy.

After injection, HA is gradually absorbed; the volume of the implant lasts for 6 to 12 months

No skin tests required. The procedure takes about 30 minutes.

FOR EVERY SKIN TYPE

Page 14: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

If all precautions are taken properly, HAFILLER® fillers do not cause an adverse reaction. Temporary symptoms after the procedure are redness, swelling, mild pain at the injection site, itching, temporary discoloration of the skin at the injection site, increased sensitivity at the injection site.

Allergic reactions develop very rarely, as HAFILLER® is identical to the hyaluronic acid of the human body. In the case of an inflammatory reaction, the patient is  recommended to consult a doctor, who will decide whether any treatment is necessary.

WHAT ABOUT ADVERSE REACTIONS?

Page 15: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

One of the advantages of HAFILLER® is that the effects are long-lasting, but  not  permanent. If all the requirements after the procedure are followed, the effect can last up to 24 months, depending on the filler and an area of correction. Effects can be prolonged with an additional correction which let to keep the initial results for 3 years. The correction requires a small amount of HAFILLER® gel injection.

For facial wrinkles and shaping facial contours, reminiscent of the treatment is  usually needed after 6-12 months. For enlarging the lips, reminiscent of the treatment is usually needed after 6 months.

The longevity of effect depend on many factors including skin type, lifestyle, age, a patient’s expectation, and the technique of injection.

HOW LONG DOES THE EFFECT LAST?

Page 16: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER®AQUA biorevitalizants serve to recover the level of hyaluronic acid, restore moisture in the skin, improve skin elasticity, complexion, skin structure, stimulation of fibroblasts.

HAFILLER®AQUA range includes 4 types of biorevitalizants.

Page 17: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

What are advantages of HAFILLER® AQUA? > The purity of the acid is supported by a European medical certificate. > Can be used for all skin types. > Treatments can be performed over the entire body. > Completely absorbed. The higher the concentration, the time for absorption is longer. > No allergic reactions. > Each package contains a sterile, disposable syringe with a solution of sodium hyaluronate in a sterile blister and two sterile disposable needles (30Gx4mm).

Page 18: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® AQUA15 (hyaluronic acid 15 mg/ml) moisturizes, gently smoothes and improves elasticity.

Excellent in the anti-aging prevention. Designed for the delicate skin around the eyes and mouth.

HAFILLER® AQUA 15 quickly disintegrates and provides a natural effect of a relaxed face.

Page 19: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® AQUA 20 (hyaluronic acid 20 mg/ml) moistures and improves elasticity of the skin, significantly increases its density, thereby causing the reduction in wrinkles.

Designed for normal skin and is used in injection into the cheeks, chin, facial contour, neck, lines around lips.

Page 20: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® AQUA 25 (hyaluronic acid 25 mg/ml) strongly moisturises and increases the density of the skin, gives the effect of wrinkles’ smoothing. It helps to rebuild damaged skin, moisturises, smooths and improves skin elasticity as well as reduces wrinkles.

Designed for flabby and normal skin. Areas of application are chin, neck, face contour, the inner side of arms and thighs, abdomen.

Page 21: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® AQUA 30 (hyaluronic acid 30 mg/ml) fills most visible wrinkles and deeply moisturises and tightens the skin as well as restores its elasticity.

Designed for dry skin and skin with visible pores. It is injected into the area around the ears, chin, face contour, hips and buttocks.

Page 22: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

HAFILLER® AQUA is a purified and viscous sodium hyaluronate in the form of  a  transparent gel. It is the non-crosslinked hyaluronic acid designed for mesotherapy treatments.

HAFILLER® AQUA stimulates fibroblasts to produce collagen and elastin and  provides moisturizing effect. HAFILLER® AQUA biorevitalizants served to recover hyaluronic acid, restore moisture in skin, improve elasticity and firmness and slows the process of skin’s aging.

HAFILLER® AQUA is biocompatible, it does not cause any allergic reactions.

HAFILLER® AQUA range includes 4 types of biorevitalizants, volume 1 ml with different concentration of hyaluronic acid – 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml. Each package contains a sterile, disposable syringe with a solution of sodium hyaluronate in a sterile blister and two sterile disposable needles (30Gx4mm). The product should only be injected by qualified and authorized persons in accordance with national regulations.

HAFILLER® AQUA

Page 23: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

The main indication for the use of HAFILLER® AQUA is the rejuvenation of the skin. HAFILLER® AQUA moisturizes, improves elasticity, smoothes out facial wrinkles and lines on neck and hands.

HAFILLER® AQUA is used in an effective anti-aging prevention. It is used in the preparation of the skin for other aesthetic treatments and immediately after them to strengthen and prolong their effects.

HAFILLER® AQUA can be used from the age of 20. However, the most effective use is in the treatment of mature skin with visible wrinkles. It is especially recommended for dry or damaged, slightly moistened skin.

WHY TO CHOOSE HAFILLER® AQUA?

Page 24: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

Before the manipulation, patient should be informed about the peculiarities of  tissue correction with hyaluronic acid and the potential adverse reaction associated with the injections, and possible side effects. It is necessary to advise patient of the information consent and fill out of the patient card.

It is recommended to use anesthesia on the site of injection or anesthetic cream (choice of method of anesthesia is individual and is determined immediately prior to the manipulation). The doctor should clean and disinfect the site of injection. Amount of the gel injected into a specific area is decided immediately before the procedure by a doctor.

HAFILLER® should be injected into healthy, not inflamed, disinfected area of skin. Volume of injected substance depends on the depth of wrinkles. After the manipulation, patient should avoid exposure to the sun and heat (sun bath, solarium, sauna) until redness and swelling disappear from the injection site and do not massage, use rough towels or scrubs. To 12h after the manipulation. do not use makeup.

ABOUT THE PROCEDURE

Page 25: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

Most commonly used techniques in mesotherapy are nappage, point by point or  Papule. The choice of technique of injection depends on type and size of wrinkles/folds.

For HAFILLER® AQUA is not recommended to use nappage technique because most of the product remains on the surface of the skin. Choosing of a point by point or a Papule technique is better to make full use of gel properties of the product.

After injecting it is necessary to massage the injection site. It is recommended to cool the injection site for 10 minutes after the procedure.

TECHNOLOGY OF INJECTION

Page 26: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

The improvement of the condition of the skin is visible after the first treatment with HAFILLER® AQUA.

In order to obtain long lasting effects, it is necessary to conduct treatments in two phases: > intensive - a series of four to six treatments at intervals of 10-14 days, > reminding - one treatment a month, performed twice a year.

The frequency of treatments is an individual case, which depends on skin condition, the concentration of used product and a patient’s response to treatment.

Deep skin hydration and firmness is maintained at about 6 months after the intensive phase.

Aesthetic effects after a series of treatments persist for many years.

FREQUENCY OF TREATMENTS

Page 27: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

If there are any contraindications to mesotherapy, treatments should not be performed.

Do not mix with other aesthetics preparations.

Test for sterility is conducted on each batch of product. The purity of the product is supported by a European medical certificate.

ADDITIONAL INFORMATION

Page 28: nanomedica full eng - SwissMedica · > Products have all clinical, toxicological, technical testings and ... The longevity of effect depend on many factors including skin type, lifestyle,

swissmedica.co.uk

swissmedicabeauty

hafillereffect

SwissMedica 61 Guildford Road

Bristol BS4 4BQ +44 77 386 58 619

[email protected]