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ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY
VOLUME 23 * NUMBER 6 * JUNE 1983
Leon H. Schmidt, Editor in Chief (1985)University ofAlabama in Birmingham
Birmingham, Alabama
Herbert L. Ennis, Editor (1987)Roche Institute of Molecular Biology
Nutley, New Jersey
Robert L. Hamill, Editor (1985)Eli Lilly & Company, Inc.
Indianapolis, Indiana
George A. Jacoby, Jr., Editor (1985)Massachusetts General Hospital
Boston, Massachusetts
Robert C. Moellering, Jr., Editor (1987)New England Deaconess Hospital
Boston, Massachusetts
John A. Washington II, Editor (1986)Mayo Clinic
Rochester, Minnesota
EDITORIAL BOARDNorris Allen (1983)Vincent T. Andriole (1984)John P. Anhalt (1984)Bascom F. Anthony (1985)Donald Armstrong (1983)George R. Aronof (1983)Robert Austrian (1983)Rihard H. Baltz (1984)Arthur L. Barry (1983)John D. Bartlett (1984)Michael Barza (1985)John E. Bennett (1984)Richard F. Bergstrom (1985)Gerald P. Bodey (1983)Lawrence E. Bryan (1985)Ward Bullock (1984)D. Buyske (1983)Anthony Chow (1985)C. Glenn Cobbs (1983)Paul S. Cohen (1983)Wlliam A. Craig (1984)Nigel A. C. Curtis (1983)Naomi Datta (1984)Lawrence E. Day (1983)Wiliam E. Dlsmukes (1984)R. Gordon Douglas, Jr. (1983)John C. Drach (1984)Theodore Eickhoff (1985)
Gertruade S. Elion (1984)Arthur English (1983)Robert J. Fm (1985)Stuart Feldman (1985)Sydney Flnegold (1985)Robert J. Ftzgerald (1983)Martn Forbes (1983)Dae N. Gerdbng (1985)David Gilbert (1984)Anthony J. Glazko (1984)Irving H. Goldberg (1985)Rihard H. Gustafson (1984)Jack Gwaltney (1983)Wendel H. Hail (1983)Maurice W. Harmon (1984)Joseph Hawkins, Jr. (1985)Mihael Higgins (1983)Dab Hsl Wang Ho (1983)Rkhard Hornick (1983)Miton Huppert (1983)George Gee Jackson (1983)James H. Jorgensen (1984)WilHm J. Jusko (1983)A. W. Karchmer (1985)Donald Kaye (1985)Geoge S. Kobayashi (1985)DoFald J.Krterd (1983)Felx Ldtner (1983)
Stephen A. Lerner (1983)Matthew E. Leviaon (1984)Stuart B. Levy (1983)Friedrich C. Luft (1984)Joan Lusk (1983)R. Luthy (1983)Francis L. Macma (1985)George H. McCracken (1984)Gerald Medoff (1983)Michael Miller (1984)Barbara Minsbew (1985)Bernard Moss (1984)Barbar E. Murray (1984)John D. Nelson (1983)Haold C. Neu (1983)J. F. Niblack (1983)James T. Park (1985)T. J. Perun (1983)Lance R. Peterson (1985)Burton M. Pogell (1984)Paul Quie (1983)Michael Rein (1983)W. H. G. Rkhards (1983)Rkhard Roberts (1985)Ian M. Rollo (1985)Richard Root (1983)Jobn P. Rosazza (1983)Jon E. Rosenblatt (1985)
Merle Sande (1985)Christne C. Sanders (1984)W. Eugene Sanders (1984)Jerome J. Schentag (1985)F. C. Sclavoino (1985)Oldrkch K, Sebek (1983)Wiliam M. Shannon (1983)Charles Shipman, Jr. (1985)Robert W. Sldwei (1984)Walter Slegenthaler (1983)P. Frederick Sparlig (1984)Bra G. Spratt (1983)Harold Standlford (1985)R. Sutherland (1985)Vera L. Sutfer (1984)Morton N. Swartz (1985)Rkbard B. Sykes (1985)Francs P. Tally (1984)Alexander Tomasz (1985)Ralph Tompsett (1985)Michael Waring (1984)Bernard Weisblum (1985)Peter G. WellIng (1985)Richard Wenzel (1983)Lowell Young (1985)Pauline K. W. Yu (1985)
Helen R. Whiteley, Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals
Walter G. Peter III, Director, PublicationsDeborah J. Shuman, Production Editor
Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society forMicrobiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects ofantimicrobial agents, anticancer agents, and chemotherapy. Instructions to authors are published in the January issue each year;reprints are available from the editors and the Publications Office. Antimicrobial Agents and Chemotherapy is publishedmonthly, and the twelve numbers are divided into two volumes per year. The nonmember subscription price is $145 per year;single copies are $14. The member subscription price is $29 (foreign, $36 [surface rate]) per year; single copies are $7.Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition ofsubmitted manuscripts, and general editorial matters should be directed to the ASM Publications Office, 1913 I St., NW,Washington, DC 20006 (area 202 833-9680).
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Araujo, Visi, 897Ayrton, John, 892
Babiuk, Lorne A., 857Ballesta, Antonio, 897Bastow, Kenneth F., 914Batheja, Roma, 866Becker, Jeffrey M., 926Bennett, S., 831Bersani, Carla, 930Bhend, Hansjorg, 888Blaser, Jurg, 888Boh6, Montserrat, 897Bonet, Montserrat, 897Boscia, Jerome A., 814Brater, D. Craig, 870Bryan, L. E., 835Bundtzen, Robert W., 881
Carr, Bernice B., 941Champlin, Richard E., 846Chang, Daniel S., 932Cheng, Yung-Chi, 914Covert, Nancy L., 926Craig, William A., 881Cynamon, Michael H., 935
Dent, J., 831Derse, David D., 914
Elena, Montserrat, 897Evans, Hugh E., 866
Fanourgakis, J. E., 870Farr6, Magin, 897Fietta, Anna, 930Fisher, Susan M., 852Fox, Jack J., 808Fujii, Ryochi, 874
Gale, Robert P., 846Gatell, Jose M., 897Georgakopoulos, P., 870Gerber, Andreus U., 881Gialdroni Grassi, Giuliana, 930Glew, Richard H., 902Grassi, Fabio, 930Gremillion, David H., 944
Harding, Stuart M., 892Hayasaka, Takeshi, 938
Author IndexHirschman, Shalom Z., 827Ho, Winston G., 846
Inaba, Hitoshi, 874
Jacobson, Jeffrey, 827Jhaveri, Ramesh C., 866Jimenez de Anta, Marfa T., 897Jules, Kethy, 907
Kafetzis, Dimitris A., 870Kaye, Donald, 814Khan, Abdul J., 866Kono, Megumi, 938Kosuzume, Hiroshi, 874Krieger, Richard E., 814Kwan, S., 835Kwok, Florence W., 881
Lash, Peter R., 932LeFrock, Jack, 941Levison, Matthew E., 814Lopez, Carlos, 808Lowy, Franklin D., 932Luthy, Ruedi, 888Lyon, Bruce R., 817
Madsen, Paul O., 881Mangiarotti, Patrizia, 930Marin, Jose L., 897Masci, Joseph, 827May, John W., 817McNamee, William, 814Meyers, Burt R., 827Misra, Vikram, 857Mochizuki, Hidenori, 874Murray, Barbara E., 799
Naider, Fred, 926Nelson, Randal C., 857Nesburn, Anthony B., 808Neu, Harold C., 907
O'Hara, Koji, 938Ohnishi, Haruo, 874Okura, Masatsugu, 874
Palmer, Gregory S., 935Panida, Jayanetra, 799Paton, Alexandra M., 892
Pavuk, Rosemary A., 902Pilkiewicz, Frank G., 852Pontzer, Raymond E., 814
Quinn, Deborah, 803
Remsburg, Beverly J., 852Rollins, Douglas E., 803Rosenfeld, Warren N., 866Ruttimann, Sigmund, 888
Sacchi, Fulvio, 930San Miguel, Juan G., 897Sasatsu, Masanori, 938Schroff, Robert W., 846Scully, Brian E., 907Seeberg, Astrid H., 918Sennello, Lawrence T., 803Shenbagamurthi, P., 926Shiomi, Yoko, 938Skurray, Ronald A., 817Smith, Bruce R., 941Sommers, De Klerk, 892Sonders, Robert C., 803Srulevitch, Elina, 827Steinfeld, Alvin S., 926Su, Tsann-Long, 808Suzuki, Yasuo, 874Sykes, Richard B., 852
Tolman, Keith G., 803Tolxdorff-Neutzling, Regina M.,
918Trousdale, Melvin D., 808Tsao, Joyce, 799
Vandenbout, Ed, 944Van Wyk, Marieta, 892Vohra, Kiran, 866Voyatzis, J., 870
Walters, Laubi, 892Watanabe, Kyoichi A., 808Welling, Peter G., 881Weston, D., 831Wiedemann, Bermd, 918Winn, Richard E., 944Winston, Drew J., 846Wise, R., 831
Zamora, Laura, 897Zar, Fred A., 947
INDEX TO DATE OF ISSUE
Month Date of Issue Pages
January 12 January 1983 1-189February 11 February 1983 191-347March 9 March 1983 349-513April 12 April 1983 515-636May 13 May 1983 637-797June 8 June 1983 799-950
AUTHOR INDEX
VOLUME 23
Acar, J. F., 248Acres, S. D., 715Aklonis, Carol A., 598Albright, James A., 356Aldridge, K. E., 536Alenius, S., 664Alestig, K., 293, 300Alexander, Donald P., 59Amiel, C., 344Andrews, J. M., 559Anhalt, John P., 683Aoki, Takashi, 506Arisawa, Mikio, 317Aron, Gary M., 390Aronoff, George R., 74Arroyo, Julio C., 710Ayarra, Javier, 323Ayrton, John, 892
Babiuk, L. A., 715Babiuk, Lorne A., 857Bailey, Denis M., 531Baker, W. L., 26Bal'a, Farid, 289Ballesta, Antonio, 897Banker, D. D., 54Bansal, Madhu B., 166Baselski, Vickie S., 161Bastow, Kenneth F., 914Batheja, Roma, 866Becker, Jeffrey M., 926Belmega, Gerhard, 429Bennett, S., 831Berg, S. William, 541Bergner-Rabinowitz, S., 397Berkowitz, Leonard B., 245Bersani, Carla, 930Betts, Robert F., 577Bhend, Hansjorg, 888Biggs, W. H., III, 738Birkness, K., 278Bittner, Marvin J., 261Bj6rnegfird, B., 300Blair, Laura L., 232Blanco, Jorge D., 479Blaser, JOrg, 888Boccazzi, Antonio, 213Bodey, Gerald P., 497, 583, 603Bogerd, Laurie, 603Bohe, Montserrat, 897Bolivar, Ricardo, 603Bonet, Montserrat, 897Boppana, Venkata K., 284Borner, Klaus, 429Boscia, Jerome A., 385, 814Bosso, John A., 413Bourgault, Anne-Marie, 793Boyd, Malcolm R., 503Boyden, Thomas W., 207Bradsher, Robert W., 191Brater, D. Craig, 870Brennan, Robert O., 273
Brier, Michael E., 74Brodeur, James P., 108Bronsdon, M. A., 320Brown, Nita, 603Browne, Michael J., 503Bryan, L. E., 835Buchanan, Christine E., 750Buisson, Jean-Pierre, 328Bundtzen, Robert W., 881Burman, L. A., 300Burns, William H., 593
Cable, D., 688Caporaso, Neil, 700Carlier, Marie B., 440Carlson, Catherine L., 634Carr, Bernice B., 941Case, Marilyn J., 649Casey, Patrick A., 252Castaneda, Yolanda S., 479Chabbert, Yves A., 622Champlin, Richard E., 846Chan, Gary M., 413Chang, Daniel S., 67, 932Chatand, Stephen A., 658Cheng, Yung-Chi, 914Cherubin, Charles E., 42Chippendale, Gwynn R., 188Chirife, Jorge, 766Chopra, I., 175Chow, Anthony W., 634Cimarusti, Christopher M., 98Clacs, Paul J., 440Clark, Judith K., 360Cleary, T. J., 536Cohen, Sidney, 151Connor, Daniel J., 790Connor, Edward, 182Cooley, Denton A., 790Cooper, Denis L., 252Coppens, Lyne, 36Corbeil, L. C., 738Cornish, Alex, 221Covert, Nancy L., 926Cowlishaw, W. A., 617Coyette, Jacques, 750Craig, William A., 881Crawford, Sharon A., 479Crossley, Kent B., 261Crowley, John J., 169Cuchural, G. J., 536Cuevas, R., 242Cummings, Marinelia C., 245Curd, J. G., 738Curvey, Ron, 19Cynamon, Michael H., 935
Dajani, Adnan S., 46Damme, Janice, 555Dankert, J., 614
Darmon, C., 248Davis, C. E., 738Davis, Robert E., 22Debbia, Eugenio, 402DeBoy, J., 278De Clercq, E., 715Deitch, Edwin A., 356Dent, J., 831Denys, Gerald A., 335Derlot, Eliane, 622Derse, David D., 914Dickman, D., 397, 796Dieckman, Elizabeth, 555DiPiro, Joseph T., 703Dobersen, Michael J., 465Domfnguez, Carmen, 545Douglas, R. Gordon, Jr., 57Dunkle, Lisa M., 232Dupont, Herbert L., 630Durack, David T., 273Dworzack, David L., 261
Edalin, G., 688Edson, Randall S., 179Edwards, L. J., 559Ehret, Josephine M., 218Elena, Montserrat, 897Ellis, Daisy H., 583Eng, Robert H. K., 700Ericsson, Charles D., 630Eron, Lawrence J., 236, 731Evans, Hugh E., 866Eyre, Linda B., 191
Fainstein, Victor, 497, 603Fanourgakis, J. E., 870Farber, Bruce F., 138Farr6, Magin, 897Fasching, Claudine E., 49Feingold, David S., 185Feldman, William E., 551Ferber, F., 293, 300Ferguson, Roger K., 284Fietta, Anna, 930Fineberg, Naomi S., 74Finegold, Sydney M., 536, 626Finlay, Kelvin R., 634Fisher, Susan M., 852Fohrman, Daniel E., 59Fong, Kei-Lai L., 603Foulds, George, 692Fox, Jack J., 808Fox, Keith R., 221Fox, Lawrence, 465Francisco, Maryalice, 774Fujii, Ryochi, 874Fukasawa, M., 195Fukuoka, Yoshikazu, 374Furman, Phillip A., 332Fuxench-Chiesa, Z., 242
i
ANTIMICROB. AGENTS CHEMOTHER.
Gadebusch, Hans H., 86, 256Gale, Robert P., 846Galgiani, John N., 207Garau, Javier, 545Garcia-Iglesias, Mercedes C., 323Gatell, Jose M., 897Gauci, C. L., 589Gauvreau, Leo, 793Georgakopoulos, P., 870Georgopapadakou, Nafsika H., 98Gerber, Andreus U., 881Gerding, Dale N., 49Ghoneim, Adeeb T. M., 483Gialdroni Grassi, Giuliana, 930Gillespie, Thomas E., 356Ginsburg, Charles M., 787Glant, Michael D., 74Glew, Richard H., 902Gleyzer, Aida, 493Glogowski, Walter, 182Golde, Alice, 328Goldenberg, Robin I., 236, 731Goldmann, Donald A., 571Goldstein, Ellie J. C., 42, 325Goldstein, F. W., 248Gombert, Myles E., 245Goodchild, John, 416Gootz, Thomas D., 91Gorbach, S. L., 536Gordon, K. P., 320Goto, Mitsuyoshi, 653Grassi, Fabio, 930Green, Deborah C., 364Greenberg, Z., 397Greer, Sheldon, 465Gremillion, David H., 944Grosso, David S., 207Gruninger, Robert P., 349, 477,
481Gutmann, L., 248
Hagberg, C.-E., 664Hammerschlag, Margaret R., 493Hansen, Vicky R., 161Hanson, Bernard, 36Hardegger, Ursula, 784Harding, Stuart M., 892Harford, Paul S., 630Harrison, William O., 541Hautefort, B., 248Hawkey, Peter M., 619Hayasaka, Takeshi, 938Hayden, Frederick G., 458Hayes, Sherrard L., 692Hermans, Paul E., 179Herszage, Le6n, 766Hess, Allan D., 593Hess, J., 614Hewlett, Erik L., 201Hill, G. B., 536Hirano, Shoji, 31Hirschman, Shalom Z., 82,Hixon, Deborah L., 731Ho, Dah Hsi W., 603Ho, Winston G., 846Hoffman, Howard E., 458
Holloway, Y., 614Holt, Jean, 780Hooper, David C., 308Huber, J. L., 293, 300
Ikeda, Akiyoshi, 31Ikeda, Yasushi, 374Inaba, Hitoshi, 874Inoue, Satoru, 641Irikura, Tsutomu, 1Irvin, James D., 390Isayama, Yasuro, 163Iversen, Peter, 338
Jacobson, Jeffrey, 827Jacobus, N. V., 536Jaffe, Aline, 622Jeffrey, Verona M., 487Jendroschek, Thomas, 429Jenkin, Howard M., 119Jensen, Klaus M.-E., 338Jerris, Robert C., 335Jhala, H. I., 54Jhaveri, Ramesh C., 866Jimenez de Anta, Marfa T., 897Johansson, N.-G., 664Johnson, David G., 207Joldersma, W., 614Jones, K. H., 293, 300Jones, M. Jeanette, 483Jonsson, Monica, 15Jorgensen, James H., 479Joseph, Arabella, 766Judson, Franklyn N., 218Jules, Kethy, 907
Kaback, H. Ronald, 526Kafetzis, Dimitris A., 870Kahan, F. M., 293, 300Kahan, J. S., 300Kantaijian, Hagop, 289Kao, Chi C., 598Kashimoto, Shigeki, 742Katae, Hiromi, 641, 742Kawabata, Tomoji, 8Kaye, Donald, 385, 814Keane, William F., 369Kelley, Eileen, 113Kemmerich, Bermd, 429Kenady, Daniel E., 706Kerbs, Sharon B., 541Khan, Abdul J., 866Khan, Mohammed Y., 349, 477,
481Kitaura, Kozo, 105Kitzis, M. D., 248Klastersky, J., 435Klastersky, Jean, 36Kobasa, William D., 385Koeppe, Peter, 429Kohn, Elisa S., 766Komatsu, T., 195Konishi, Hidetoshi, 653Kono, Megumi, 506, 938
Korzeniowski, Oksana M., 385Kosuzume, Hiroshi, 874Kouri, Y., 242Krieger, Richard E., 814Kropp, H., 300Kuroda, Kyoichi, 31Kusajima, Hisao, 1Kwan, S., 835Kwok, Florence W., 881
Lagast, H., 435Lamminsivu, Ulla, 721Larsson, A., 664Lash, Peter R., 932Latif, Razia, 46Laurent, Guy, 440LeBlanc, Barbara, 497LeFrock, Jack, 941LeFrock, Jack L., 774Levison, Matthew E., 385, 814Lewis, Marcia E., 487Lietman, Paul S., 133Lifiares, Josefina, 545Lindborg, B., 664Linner, E. C., 142Lode, Hartmut, 429Lopez, Carlos, 808Loscertales, Jesus, 323Lowy, Franklin D., 67, 932Luft, Friedrich C., 74Luthy, Ruedi, 888Lyon, Bruce R., 817
Maack, Richard W., 188Madsen, Paul O., 338, 881Maduri Traczewski, Maria, 571Magera, Barbara E., 710Maksymiuk, Andrew, 603Malamy, M. H., 726Malewicz, Barbara, 119Mangiarotti, Patrizia, 930Manning, Nancy S., 551Mannisto, Pekka T., 721Mansson-Rahemtulla, Britta, 267Mantyla, Raba, 721Manuel, C., 344Manzella, John P., 360Marin, Jose L., 897Marino, Andrew A., 356Markowitz, Norman, 450Marks, Melvin I., 658Marsh, P. K., 726Marshall, David C., 692Martin, John C., 676Maruyama, Hiromi B., 317Masci, Joseph, 827Mates, Susan M., 526Mathewson, John J., 495Matsen, John M., 413Matthews, Thomas R., 676Mattila, Jyrki, 721Matzke, Gary R., 369May, John W., 817McCall, Charles E., 565McCloskey, R. V., 536
ii AUTHORINDEX
AUTHOR INDEX in
McCracken, George H., Jr., 213,341, 787
McDonnell, Richard W., 151McDowell, Thomas D., 750McGuffin, Robert W., 169McGuirt, Paul V., 332McHugh, Gail L., 308McKinstry, Doris N., 125McMahon, F. Gilbert, 692McNamee, William, 814Meeker, Timothy C., 169Meisinger, M. A. P., 293, 300Meola, Shirlee M., 313Meredith, David M., 416Meulemans, A., 344Meyers, Burt R., 827Michel, J., 397, 796Miller, Michael H., 526Miller, Thomas, 422, 500Minagawa, Harushige, 105Minami, Akira, 641, 742Misra, V., 715Misra, Vikram, 857Mitani, Kenji, 163Mitsuhashi, Susumu, 407Miyahara, Tadashi, 8Mochizuki, Hidenori, 874Moellering, Robert C., Jr., 138Momsen, Maureen, 119Moss, Margaret Y., 503Motoi, Isamu, 31Murphy, Patricia, 571Murray, Barbara E., 495, 630, 799Murray, Cecilia, 780Myers, Gwendolyn A., 201
Nadakavukaren, Mathew J., 610Naider, Fred, 926Nakamizo, Nobuhiro, 105Nakamoto, Yoshinori, 653Nakamura, Masuhisa, 8Nakamura, Shinichi, 641, 742Nakata, Katsuhisa, 742Nakazawa, Hisashi, 407Nakazawa, Muneo, 163Nelson, Randal C., 857Nelson, Susan M., 477, 481Nesburn, Anthony B., 808Neu, Harold C., 63, 907Neuhaus, Ellen G., 67Nevarez, M., 242Nielsen, Ole S., 338Noguchi, H., 195Norman, James O., 313Norman, John C., 790Norrby, S. R., 293, 300Norrby, S. Ragnar, 15, 352Novitsky, Thomas J., 649Nykainen, Sirkka, 721
Obaid, Stephen R., 349, 477Oberg, B., 664O'Brien, Mark M., 692O'Connor, John R., 379, 531
Ogawa, Hidemasa, 509O'Hara, Koji, 938Ohkawa, Mitsuo, 31Ohnishi, Haruo, 874Ohshima, Junko, 317Ohya, Satoshi, 522Okasho, Akira, 31O'Keefe, J. P., 536Okuda, T., 195Okura, Masatsugu, 874Olsen, Kurt, 787Onwubalili, J. K., 589Osada, Yasuaki, 509Osseiran, Maher, 289O'Sullivan, Joseph, 598Overturf, G., 688Owens, William E., 626
Palmer, Gregory S., 935Pamenter, Richard W., 207Panida, Jayanetra, 799Park, Choong H., 236, 731Parks, Leo W., 515Patel, Indravadan H., 191Patel, Lehka, 526Paton, Alexandra M., 892Pavuk, Rosemary A., 902Pearson, Richard D., 201Pedler, Steven J., 619Pegram, P. Samuel, Jr., 565Perea, Evelio J., 323Perez, Jos6 L., 545Perez, M., 242Peterson, Lance R., 49Phillips, Susan, 422Phillpotts, R. J., 671Pierson, C. L., 536Pilkiewicz, Frank G., 852Plorde, J. J., 320Pohlod, Donald J., 450Polak, Annemarie, 79Pollock, Helen M., 780Pontzer, Raymond E., 814Poretz, Donald M., 236, 731Porter, Roderick A., 416Postic, Bosko, 710Pottratz, Scott T., 74Preheim, Laurel C., 261Pruitt, Kenneth M., 267
Quinn, Deborah, 803Quinn, Edward L., 450
Ram, Madhira D., 706Ramfrez-Ronda, C. H., 242Rangnekar, V. M., 54Raper, Robert H., 416Remsburg, Beverly J., 852Riff, L., 364Rissler, Jane F., 22Robinson, J. A., 589Rodriguez, J., 242Rodriguez, Russell J., 515
Rogers, J. D., 293Rogol, M., 796Rollins, Douglas E., 803Root, Carol J., 218Rosansky, Steven J., 710Rosenfeld, Warren N., 866Roth, Frieda K., 577Rothstein, Gerald, 59Rotmensch, Heschi H., 284Rouillard, Danielle, 328Royer, Rent, 328Rubinstein, Ardon, 778Russo, Mary E., 59Ruttimann, Sigmund, 888Rylander, Margareta, 352Ryther, Sally S., 649
Sacchi, Fulvio, 930Sack, D., 278Sacks, Stephen L., 637Saikawa, Isamu, 374Saito, Atsushi, 374Sakata, Yasutaka, 213Salvador, Patricio, 583Salzer, William, 565Sanders, Christine C., 91San Miguel, Juan G., 897Saral, Rein, 593Saravolatz, Louis D., 450Sasatsu, Masanori, 506, 938Sawaki, Masaru, 31Schaad, Urs B., 252Schauf, Victoria, 364Scheld, W. Michael, 108Schell, Ronald F., 774Schito, Gian C., 402Schoenknecht, F. D., 142Schroff, Robert W., 846Schwarzenbach, Jannpeter, 490Schwenzer, Kathryn S., 683Scott, G. M., 589Scribner, Ronald K., 658Scully, Brian E., 907Seeberg, Astrid H., 918Sekizaki, Tsutomu, 163Selepak, Sally T., 172Selitrennikoff, Claude P., 757Sennello, Lawrence T., 803Shenbagamurthi, P., 926Sherris, J. C., 142Shimada, Jingoro, 1, 8Shimamura, Masayoshi, 31Shimell, M. J., 726Shimizu, Masanao, 641, 742Shiomi, Yoko, 938Shiota, Faith M., 169Shockman, Gerald D., 750Shoda, Ryochu, 31Shulman, Michael, 42Shungu, Daniel L., 86, 256Siegel, Jane D., 341Siegel, Martin S., 169Sim, lain S., 416Simpson, Margaret L., 349, 481Skurray, Ronald A., 817
VOL. 23, 1983
ANTIMICROB. AGENTS CHEMOTHER.
Slee, Andrew M., 379, 531Smalley, David L., 161Smee, Donald F., 676Smith, Bruce R., 774, 941Smith, Craig R., 133Smith, Margaret A., 617Smith, M. C. M., 175Smith, Ronald G., 583Smith, Sandra A., 98Smith, Sharon M., 700Snepar, Richard, 385Sommers, De Klerk, 892Sonders, Robert C., 803Souser, Margaret L., 598Spedtor, Stephen A., 113Spicehandler, Jonathan, 191Spyker, Daniel A., 458Srulevitch, Elina, 827Stankewich, Joseph P., 692Steadham, Joe, 19Steele, John C. H., Jr., 703Steele, Russell W., 191Steigbigel, Neal H., 67Steinfeld, Alvin S., 926Stening, G., 664Sterkers, O., 344Sterling, Rosalyn P., 790Stem, M., 548Stevens, David A., 207Stiver, H. Grant, 634Stockdale, P. H. G., 715Stone, John R., Jr., 541Stuart, Robert K., 593Su, Tsann-Long, 808Sud, Inder Jit, 185Sugata, Toshiaki, 31Sugawara, Shinichi, 522Sugeno, Kooichi, 8Sugarman, A. Arthur, 125, 548Sugimoto, Chihiro, 163Sundelof, J. G., 300Sutter, Vera L., 325, 483Suzuki, Yasuo, 874Swabb, Edward A., 125, 548Swanson, Brian N., 284Swartz, Mark D., 308Swartz, Morton N., 308Swavely, Todd S., 750Sweeney, Helen M., 151Swenson, Jana M., 335Sykes, Richard B., 98, 852
Taki, Hideo, 374Tally, F. P., 536, 726Tannini, P. B., 536Tannir, Nizar, 289Taylor, A. Thomas, 703Taylor, Fred R., 515Taylor, P. C., 142Teh, Chong-Ze, 637Teltow, Glenna J., 390Tenney, James H., 188Tenover, F. C., 320Terakado, Nobuyuki, 163Thadepalli, Haragopal, 166Thomas, Marion, 341Thornsberry, Clyde, 335Threlkeld, Norma, 341Tofte, Robert W., 261Tokunaga, Shuji, 31Tolman, Keith G., 803Tolxdorff-Neutzling, Regina M.,
918Towner, K. J., 617Tran Ba Huy, P., 344Trousdale, Melvin D., 808Tsao, Joyce, 799Tulkens, Paul M., 440Turner, Andrew, 619Tyndall, Michael, 113Tyrrell, D. A. J., 671Tyrrell, David L. J., 487
Uchida, Hiroshi, 1Ueda, Yasushi, 1, 8, 374Uwaydah, Marwan, 289
Vance, Paula H., 19Vandenbout, Ed, 944Vanderhaeghe, Hubert J., 440van der Stuyf, L., 364Van Etta, Linda L., 49Van Laethem, Y., 435Van Wyk, Marieta, 892Varaldo, Pietro E., 402Venglarcik, John S., III, 232Verheyden, Julien P. H., 676Viney, Julie, 416Vlasses, Peter H., 284Vohra, Kiran, 866Voyatzis, J., 870
Waldorf, Alayn R., 79Walker, Naomi E., 74Wallace, J., 671Wallace, Richard J., Jr., 19Walters, Laubi, 892Ward, R. J., 589Waring, Michael J., 221Warren, Kenneth G., 487Washington, John A., II, 179Wassef, M., 344Watanabe, Kyoichi A., 808Weber, Andrew H., 658Weidler, Donald J., 692Weinberg, Ellen, 86, 256Weinfeld, R. E., 583Weinfeld, Robert E., 191Welch, David F., 658Welling, Peter G., 881Wells, J., 278Weston, D., 831White, William E., Jr., 267Whitmore, Susan C., 22Wiedemann, Bernd, 918Wigren, David I., 349Wilkinson, Brian J., 610Wingard, John R., 593Winn, Richard E., 944Winslow, Dean L., 555Winston, Drew J., 846Wise, R., 559, 831Wiss, Karen, 19Witebsky, Frank G., 172Wolfson, John S., 308Wright, D. J., 589Wunderlich, A. C., 738Wtist, Jtirg, 490, 784
Yamagishi, Junichi, 641, 742Yamaji, Takehisa, 1, 8Yamamoto, Ikuyoshi, 653Yamashina, Hajime, 653Yamashiro, Yoshiko, 374Yamazaki, Mitsuo, 522Yano, K., 195Yasuda, Takashi, 374Yogev, Ram, 182Yoshida, Tadashi, 8Younkin, Scott W., 577Yu, Pauline K. W., 179
Tagart, V. B., 671Takase, Yoshiyuki, 641, 742
Wachsmuth, K., 278Wadsworth, Harry J., 416
iv AUTHORINDEX
Zamora, Laura, 897Zar, Fred A., 947
SUBJECT INDEX
VOLUME 23
AC-1370phagocyte functions, 874
Actinomyces naeslundiiWIN 41464-2, 374
Actinomyces viscosusWIN 41464-2, 374
Acyclovircombined with amphotericin B
pseudorabies virus, 119herpes simplex virus, 487herpesvirus 1, 332lymphocyte functions, 593marrow progenitor cells, 593protein synthesis, 332
Agar dilutionE. corrodens, 42susceptibility testing, 42
Allium sativumantifungal activity, 700
AM-715see norfloxacin
Amantadineinfluenza virus, 503, 577
Amantadine hydrochloridepharmacokinetics, 458side effects, 458
Amdinocillinpharmacokinetics, 827
Amikacinauditory toxicity, 897gentamicin, 245imipemide, 245nephrotoxicity, 897pharmacokinetics, 888renal insufficiency patients, 888S. faecalis, 245
Aminoglycosidesaccumulation kinetics, 74lysosomal phospholipases, 440Nocardia spp., 19renal parenchyma in rats, 74
Aminoglycosidic aminocyclitolsEnterobacteriaceae, 902
6-Aminopenicillanic acidfluorescamine reaction, 26penicillin acylase activity, 26
Amoxicillinchildren, 252clavulanic acid, 252clavulanic acid combinationM. fortuitum, 935pharmacokinetics, 252
Amphotericin BC. albicans, 185combined with acyclovir
pseudorabies virus, 119human granulocyte progenitor cells, 169ketoconazole, 185
Ampicillincomparative activity
temocillin, 182H. influenzae, 182, 364N. gonorrhoeae, 242pneumococci, 397
Anaerobic bacteriabromidoprim, 490cefmenoxime, 626, 780cefotetan, 626ceftriaxone, 780imipemide, 626metioprim, 490sulfonamides, 490
Antifungal antibioticsdetectionN. crassa, 757
Antineoplastic agentsP-lactams, 374
Aphidicolinherpes simplex virus, 914
Arabinosylnucleosidesherpes simplex virus, 914
Aspirininfluenza A virus, 577
AT-2266activity in vitro, 658antibacterial properties, 641comparative activity
gentamicin, 742nalidixic acid, 742norfloxacin, 742pipemidic acid, 742
15-Azasterolantifungal activity, 515sterol biosynthesis, 515
Azthreonamsee aztreonam
Aztreonambioavailability, 548high-pressure liquid chromatography, 852N. gonorrhoeae, 477pharmacokinetics, 125
B16-Fl melanoma cellsdiflubenzuron, 313melanogenesis inhibition, 313
Bacterial infectionsceftazidime, 236ceftriaxone, 261moxalactam, 565
Bacteroides fragilisP-lactams, 166
Bacteroides fragilis groupclindamycin resistant
broth-disk surveillance, 947susceptibility in U.S., 536
v
ANTIMICROB. AGENTS CHEMOTHER.
Bacteroides spp.cindamycin resistance, 726
Bay 09867comparative activity, 559
Bicozamycinnonparasitic diarrhea, 630
Bioassay indicator organismscommonly used drugs, 703
Bispyridinesantimicrobial activity, 531antiplaque activity, 531structure, 531
BombayS. typhimurium R plasmids, 54
Bone infectionsceftriaxone, 731
Bordetella spp.chlorpromazine, 201
Bovine herpesvirus 1(E)-5-(2-bromovinyl)-2'-deoxyuridine, 715, 857
BRL 17421see temocillin
Bromidoprimanaerobic bacteria, 490
BromopenicillanateP-lactamase activity, 63
(E)-5-(2-Bromovinyl)-2'-deoxyuridinebovine herpesvirus 1, 715, 857lymphocyte functions, 593marrow progenitor cells, 593
Broth-disk surveillanceB. fragilis group, 947clindamycin, 947
Campylobacterjejunisusceptibility, 796tetracycline resistance, 320
Candida albicansamphotericin B, 185ketoconazole, 105, 185pH effect, 105
Carbenicillintobramycin inactivation, 653
Cefamandolecombined with tobramycin, 36comparative activitycefmenoxime, 774
H. influenzae, 364staphylococcal infections, 36
Cefazolinpneumococci, 397
Cefmenoximeanaerobic bacteria, 626, 780comparative activity
cefamandole, 774cefoperazone, 774cefotaxime, 774cephalothin, 774moxalactam, 774
gonorrhea, 349penetration
gallbladder bile, 941tissue, 941
pharmacokinetics, 803Cefodizime
activity in vitro, 9071-lactamase stability, 907N. gonorrhoeae, 477
CefonicidN. gonorrhoeae, 541open-heart surgery, 790skin infections, 944urinary tract infections, 814
Cefoperazonecirrhosis, 385comparative activitycefmenoxime, 774
K. pneumoniae, 435meningitis, 688N. gonorrhoeae, 242, 541P. aeruginosa, 435pharmacokinetics, 385, 413, 429, 866
Ceforanidebiliary levels, 706N. gonorrhoeae, 541
Cefotaximecomparative activitycefmenoxime, 774
N. gonorrhoeae, 242, 477, 541pharmacokinetics, 429
Cefotetananaerobic bacteria, 626pharmacokinetics, 31
Cefoxitincomparative concentrations, 323N. gonorrhoeae, 242, 477, 541
Cefsulodinpharmacokinetics, 369
Ceftazidimebacterial infections, 236breast milk, 479E. coli, 213H. influenzae, 213K. pneumoniae, 435meningitis, 213N. gonorrhoeae, 477P. aeruginosa, 435pharmacokinetics, 892S. pneumoniae, 213
Ceftizoximeknown surface area/volume ratio, 49N. gonorrhoeae, 242, 541penetration kinetics, 49
Ceftriaxoneanaerobic bacteria, 780bacterial infections, 261bone infections, 731C. freundii, 317diffusion into cerebrospinal fluid, 46distribution in mothers and infants, 870gonorrhea, 218,3-lactamase inhibition, 317meningitis, 46, 191neoplastic disease, 583N. gonorrhoeae, 541pharmacokinetics, 191, 341pharmacology, 583soft tissue infections, 731
Cefuroximemononuclear leukocytes, 360N. gonorrhoeae, 477
Cephalosporins
vi SUBJECT INDEX
VOL. 23, 1983
aminothiazolyl iminomethoxycefodizime, 907
C. trachomatis, 493E. cloacae P-lactamases, 918S. aureus resistance mechanism, 938semisyntheticAC-1370, 874
Cephalothinclavulanic acid combinationM. fortuitum, 935
comparative activitycefmenoxime, 774
Cephamycins,-lactamase stability, 522M. morganii, 522penicillin-binding protein affinity, 5227a substitution, 522
CGP 3543/Esee bicozamycin
Chemotherapyphysiological manipulations, 422renal infection, 422
Chlamydia trachomatiscephalosporins, 493,-lactams, 493
ChloramphenicolE. coli, 551H. influenzae, 364, 551L. monocytogenes, 555pneumococci, 397
ChlorpromazineBordetella spp., 201
CI-919activity in vitro, 658
Cirrhosiscefoperazone, 385
Citrobacterfreundiiceftriaxone, 317P-lactamase inhibition, 317
Clavulanic acidamoxicillin, 252children, 252M. fortuitum
amoxicillin combination, 935cephalothin combination, 935
pharmacokinetics, 252, 831ticarcillin combination, 831tissue penetration, 831
ClindamycinB. fragilis group resistance
broth-disk surveillance, 947C. difficile, 784pneumococci, 397resistanceBacteroades spp., 726
Clostridium difficileresistance
clindamycin, 784erythromycin, 784tetracycline, 784
Clotrimazoleantifungal activity, 515sterol biosynthesis, 515
Corynebacterium xerosisR plasmids, 506
Cytomegalovirustrifluorothymidine, 113
SUBJECT INDEX vii
Deoxycytidineanalogs
herpes simplex virus, 465Deoxyuridine
analogsantiviral activity, 416
Diarrheanonparasitic
bicozamycin, 630DiflubenzuronB16-Fl melanoma cells, 313melanogenesis inhibition, 313
9-(3,4-Dihydroxybutyl)guanineherpesvirus, 664
9-(1,3-Dihydroxy-2-propoxymethyl)guanineherpesvirus, 676
(S)-9-(2,3-Dihydroxypropyl)adeninelymphocyte functions, 593marrow progenitor cells, 593
Disk diffusion susceptibilityinterpretive standards, 256norfloxacin, 256
DL 473comparative activity
rifampin, 338concentrations in canine bone, 338
DL-8280see ofloxacin
Eikenella corrodensagar dilution, 42microtiter broth dilution, 42susceptibility testing, 42
Endocarditispenicillin, 67, 273S. mitis, 67S. sanguis, 67streptococcal, 273
EndotoxinsLimulus amoebocyte lysate, 649
Enterobacter cloacaecephalosporin resistance, 918P-lactamase induction, 91P-lactamases, 918
Enterobacteriaceaeaminoglycosidic aminocyclitols, 902semisynthetic penicillins, 902sulfonamide susceptibility, 617trimethoprim resistance, 617urinary tract infections, 617
Enterococciresistance, 799Thailand, 799
Enviroximerhinovirus infection, 671
Erythromycincarbon dioxide, 325C. difficile, 784N. gonorrhoeae, 242pneumococci, 397
Escherichia coliampicillin, 108antimicrobial resistance, 278ceftazidime, 213chloramphenicol, 551enterotoxigenicity transfer, 278
ANTIMICROB. AGENTS CHEMOTHER.
fluorescence assay, 175gentamicin, 108K-12 mutants, 622P-lactamase, 308P-lactam resistance, 622meningitis, 108, 213methylprednisolone, 108monobactam binding, 98penicillin-binding proteins, 98screening method, 308tetracycline, 175
5-Ethyl-2'-deoxyuridineherpes simplex virus, 637
5-Fluorcytosinemechanisms of action, 79
Fluorescamine reaction6-aminopenicillanic acid, 26penicillin acylase activity, 26
Fluorescence assayE. coli, 175tetracycline, 175
Fluorescence polarization immunoassaystreptomycin, 683
1-(2'-Fluoro-2'-deoxy-,-D-arabinofuranosyl)thymineherpes simplex virus, 808
N-Formimidoyl thienamycinsee imipemide
Fungizoopathogenic
polyoxin D, 926Furosemide
nephrotoxicity, 133toxicity, 133
Garlicantifungal activity, 700
Gastrointestinal tract pathogensnorfloxacin, 86
Gentamicinamikacin, 245bacterial uptake, 835comparative activityAT-2266, 742
icteric sera, 172imipemide, 245infusion in rats, 344intranasal administration, 778moxalactam combination
P. aeruginosa, 179resistance plasmid transfer, 151S. aureus, 151, 526S. epidermidis, 151S. faecalis, 245Syva EMIT system, 172
Gonorrheacefmenoxime, 349ceftriaxone, 218penicillin, 349penicillin G, 218
Haemophilus influenzaeampicillin, 182, 364
cefamandole, 364ceftazidime, 213chloramphenicol, 364, 551meningitis, 213temocillin, 182
Haemophilus somnussusceptibility, 163
Halopenicillanatesbromopenicillanate, 63iodopenicillamate, 63
Herpes simplex virusacyclovir, 332, 487aphidicolin, 914arabinosylnucleosides, 914deoxycytidine analogs, 4655-ethyl-2'-deoxyuridine, 6371-(2'-fluoro-2'-deoxy-,3-D-arabinofuranosyl)thy-
mine, 808phosphonoformic acid resistance, 914pokeweed antiviral protein, 390recovery from trigeminal ganglia, 487
Herpesvirus9-(3,4-dihydroxybutyl)guanine, 6649-(1,3-dihydroxy-2-propoxymethyl)guanine, 676
High-pressure liquid chromatographyaztreonam, 852
Hormonesketoconazole, 207
Human granulocyte progenitor cellsamphotericin B, 169ketoconazole, 169miconazole, 169
Imipemideamikacin, 245anaerobic bacteria, 626dehydropeptidase inhibitors, 300gentamicin, 245intrathecal penetration, 634MK791, 634pharmacokinetics, 293S. faecalis, 245tolerance, 293urinary recovery, 300
Influenza virusamantadine, 503, 577aspirin, 577ribavirin, 503
Interferonbone marrow transplant recipients, 846corticosteroids, 589febrile reactions, 589trace metals, 589
Iodopenicillanate3-lactamase activity, 63
Ketoconazoleamphotericin B, 185C. albicans, 105, 185hormones, 207human granulocyte progenitor cells, 169pharmacology, 787pH effect, 105
Klebsiella pneumoniae
viii SUBJECT INDEX
VOL. 23, 1983
cefoperazone, 435ceftazidime, 435
,B-Lactamaseceftriaxone, 317cephamycin stability, 522C.freundii, 317E. cloacae, 91, 918E. coli, 308inhibition
bromopenicillanate, 63iodopenicillanate, 63
M. morganii, 522Tn2011, 407
1-Lactamsantineoplastic agents, 374B. fragilis, 166C. trachomatis, 493N. asteroides, 248Nocardia spp., 19phagocytes, 930resistance
E. coli K-12 mutants, 622Limulus amoebocyte lysate
endotoxin detection, 649Listeria monocytogenes
chloramphenicol, 555rifampin, 555
Lymphocyte functionsacyclovir, 593(E)-5-(2-bromovinyl)-2'-deoxyuridine, 593(S)-9-(2,3-dihydroxypropyl)adenine, 593trifluorothymidine, 593vidarabine, 593
Lysosomal phospholipasesaminoglycosides, 440
Marrow progenitor cellsacyclovir, 593(E)-5-(2-bromovinyl)-2'-deoxyuridine, 593(S)-9-(2,3-dihydroxypropyl)adenine, 593trifluorothymidine, 593vidarabine, 593
Mecillinamstreptococcigrowth, 750macromolecular synthesis, 750penicillin-binding proteins, 750
Mefoxacinsee ofloxacin
Meningitisampicillin, 108cefoperazone, 688ceftazidime, 213ceftriaxone, 46, 191E. coli, 108, 213gentamicin, 108H. influenzae, 213methylprednisolone, 108moxalactam, 289pneumococcal, 108S. pneumoniae, 213
MethicillinS. aureus
SUBJECT INDEX ix
peptidoglycan synthesis, 610susceptible, 450resistant, 450
staphylococcal resistance, 932Methylprednisolone
ampicillin, 108E. coli, 108gentamicin, 108meningitis, 108pneumococci, 108
Metioprimanaerobic bacteria, 490
Metronidazolepharmacokinetics, 721
MezlocillinN. gonorrhoeae, 242pneumococci, 397
Miconazoleantifungal activity, 515human granulocyte progenitor cells, 169sterol biosynthesis, 515
Microtiter broth dilutionE. corrodens, 42susceptibility testing, 42
MK-0366see norfioxacin
MK0787see imipemide
MK791imipemide, 634
Monobactamsantibacterial activity, 98binding to penicillin-binding proteins, 98biosynthesis, 598sulfur metabolism, 598
Mononuclear leukocytescefuroxime, 360moxalactam, 360
Morganella morganiicephamycins, 522penicillin-binding proteins, 522
Moxalactamcombined with gentamicin
P. aeruginosa, 179comparative activitycefmenoxime, 774
gram-positive aerobic infections, 565meningitis, 289mononuclear leukocytes, 360N. gonorrhoeae, 242, 541P. aeruginosa, 179pharmacokinetics, 429renal disposition, 8stop-flow analysis, 8
Mycobacterium fortuitumamoxicillin, 935cephalothin, 935clavulanic acid, 935
Mycoplasma pneumoniaeofloxacin, 509
Naficillinbleeding, 59platelet dysfunction, 59
Nalidixic acid
ANTIMICROB. AGENTS CHEMOTHER.
comparative activityAT-2266, 742
Neisseria gonorrhoeaeaztreonam, 477cefodizime, 477cefonicid, 541cefoperazone, 541ceforanide, 541cefotaxime, 477, 541cefoxitin, 477, 541ceftazidime, 477ceftizoxime, 541ceftriaxone, 541cefuroxime, 477non-p-lactamase-producing, 242moxalactam, 541penicillin, 477, 541Sch 29,482, 481susceptibility, 242
Neoplastic diseaseceftriaxone, 583
Neurospora crassaantifu l antibiotic detection, 757
2-Nitronaphthofuran derivativeschicken embryo fibroblasts, 328Rous sarcoma virus, 328
Nocardia asteroidesfIactams, 248susceptibility, 248
Nocardia spp.aminoglycosides, 19,-lactams, 19taxonomy, 19
Norfloxacinantibacterial activity, 15, 86comparative activityAT-2266, 742
disk diffusion susceptibility testing, 256efficacy in vivo, 352gastrointestinal tract pathogens, 86oral doses, 284renal excretion, 1resistance, 188subinhibitory concentrations, 188tissue penetration, 352
Octenidine dihydrochlorideplaque-forming microorganisms, 379
OfloxacinM. pneumoniae, 509
Open-heart surgerycefonicid, 790
Oxacillinminimal bactericidal concentrations, 142rifampin combination, 571S. aureus, 142, 232, 571
Penicillinacylase activity
6-aminopenicillanic acid, 26fluorescamine reaction, 26
endocarditis, 67gonorrhea, 349N. gonorrhoeae, 242, 477, 541semisynthetic
Enterobacteriaceae, 902Proteeae, 619
S. mitis, 67S. sanguis, 67streptococcal endocarditis, 273viridans group streptococci, 614
Penicillinasebactericidal activity, 738complement activity, 738
Penicillin-binding proteinscephamycin affinity, 522E. coli, 98M. morganii, 522S. aureus, 98
Penicillin Ggonorrhea, 218pneumococci, 397
Periodontal disease-associated bacteriaantimicrobial susceptibilities, 483
Peritoneal dialysis patientsvancomycin, 710
Peroxidase-thiocyanate-peroxide antibacterial systemDNA damage, 267
PhagocytesP-lactams, 930
Pharmacokineticsamantadine hydrochloride side effects, 458aztreonam, 125cefotetan, 31rimantadine hydrochloride side effects, 458
Phosphonoformic acidherpes simplex virus resistance, 914
Pipemidic acidcomparative activityAT-2266, 742
PiperacillinN. gonorrhoeae, 242pharmacokinetics, 881tobramycin inactivation, 653
PlasmidsS. aureus resistance, 817S. typhimurium, 54tetracycline resistance, 320
Pneumococciampicillin, 108gentamicin, 108meningitis, 108methylprednisolone, 108penicillin-resistant
serotype distribution, 397susceptibility, 397
S. pneumoniae, 545Pokeweed antiviral protein
herpes simplex virus, 390Polyoxin D
zoopathogenic fungi, 926Probenecidcefmenoxime pharmacokinetics, 803
Propionibacterium acnessusceptibility, 335
Proteeaesemisynthetic penicillins, 619
Pseudomonas aeruginosacefoperazone, 435ceftazidime, 435gentamicin, 179moxalactam, 179
x SUBJECT INDEX
SUBJECT INDEX xi
Pseudomonas paucimobilissusceptibility, 161
Pseudorabies virusacyclovir, 119amphotericin B, 119BHK-21 cells, 119
Pyelonephritisscarred renal tissue, 500
Quinolonecarboxylic acid derivativesAM-715, 1
Renal dipeptidase enzyme inhibitorimipemide, 634
Renal infectionchemotherapy, 422
Renal insufficiency patientsamikacin pharmacokinetics, 888
Renal parenchymaaminoglycoside kinetics, 74
Rhinovirus infectionenviroxime, 671
Ribavirininfluenza virus, 503
Rifampincombinations
oxacillin, 571teichomycin, 402vancomycin, 402
comparative activityDL 473, 338
concentrations in canine bone, 338L. monocytogenes, 555S. aureus, 571
Rifamycin derivativesDL 473, 338
Rimantadine hydrochloridepharmacokinetics, 458side effects, 458
Rous sarcoma virus2-nitronaphthofuran derivatives, 328
R plasmidsC. xerosis, 506S. typhimurium, 54
Salmonella krefeldplasmid-mediated resistance, 495sulfamethoxazole, 495trimethoprim, 495
Salmonella typhimuriumR plasmids
incompatibility groups, 54resistance, 54
Sch 29,482N. gonorrhoeae, 481
Silver-nylon, 356Skin infections
cefonicid, 944SM-1652
antibacterial activity, 195Soft tissue infections
ceftriaxone, 731SpectinomycinN. gonorrhoeae, 242
Spiroplasmasheavy-metal salts, 22
SQ 26,776see aztreonam
Staphylococcicoagulase negative, 932gentamicin, 932methicillin resistance, 932rifampin, 932urinary infections, 793vancomycin, 932
Staphylococcus aureuscephalosporins
resistance mechanism, 938drug abusers, 450gentamicin
resistance plasmids, 151uptake, 526
membrane potential, 526methicillin resistantdrug abusers, 450peptidoglycan synthesis, 610
monobactam binding, 98oxacillin, 142, 232, 571penicillin-binding proteins, 98resistance plasmids, 817rifampin, 571susceptibility patterns, 450
Staphylococcus epidermidisgentamicin, 151
Streptococciendocarditis, 273mecillinam, 750penicillin, 273viridans group
detection, 614penicillin tolerant, 614
Streptococcus faecalisamikacin, 245gentamicin, 245imipemide, 245
Streptococcus mitisendocarditis, 67penicillin, 67
Streptococcus mutansWIN 41464-2, 374
Streptococcus pneumoniaeceftazidime, 213meningitis, 213pneumococcal disease, 545resistance, 545serotype distribution, 545
Streptococcus sanguisendocarditis, 67penicillin, 67WIN 41464-2, 374
Streptomycinbacterial uptake, 835fluorescence polarization immunoassay, 683
Sugarwound treatment, 766
Sulbactampharmacokinetics, 692
Sulfamethoxazoletrimethoprim combinationpneumococci, 397S. krefeld, 495
VOL. 23, 1983
ANTIMICROB. AGENTS CHEMOTHER
Sulfonamidesanaerobic bacteria, 490Enterobacteriaceae, 617urinary tract infections, 617
Susceptibility testingagar dilution, 42E. corrodens, 42microtiter broth dilution, 42
Syva EMIT systemgentamicin, 172
TaxonomyNocardia spp., 19
Teichomycinactivity in vitro, 402rifampin combination, 402
Teichomycin A2comparative study, 497
Temocilhincomparative activity
ampicillin, 182H. influenzae, 182
TetracyclineC. difficile, 784C. jejuni resistance, 320E. coli, 175fluorescence assay, 175N. gonorrhoeae, 242
Ticarcillinclavulanic acid combination, 831pharmacokinetics, 831tissue penetration, 831tobramycin inactivation, 653
Tinidazolepharmacokinetics, 721
Tn2011~-lactamase, 407
Tobramycinauditory toxicity, 897cefamandole combination, 36inactivation
carbenicilhin, 653piperacillin, 653ticarcillin, 653
nephrotoxicity, 897staphylococcal infections, 36
Trifluorothymidinecytomegalovirus, 113lymphocyte functions, 593marrow progenitor cells, 593
TrimethoprimEnterobacteriaceae, 617sulfamethoxazole combinationpneumococci, 397S. krefeld, 495
urinary tract infections, 617Triostin antibioticsDNA binding, 221preparation, 221
Urinary infectionscefonicid, 814Enterobacteriaceae, 617staphylococci, 793sulfonamide, 617trimethoprim, 617
Vancomycinactivity in vitro, 402hepatic function, 603peritoneal dialysis patients, 710pharmacokinetics, 710pharmacology, 603rifampin combination, 402stapoylococcal infections, 36staphylococcigentamicin combinations, 932rifampin combinations, 932
toxicity, 138Vidarabinelymphocyte functions, 593marrow progenitor cells, 593
WIN 41464-2plaque-forming microorganisms, 379
Wound treatmentsugar, 766
xii SUBJECT INDEX
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Highest Degree Year Major
Granting Institution
Position Experience
Signature of Nominee
Nominated by(Signature of Society member)
0 0Journal of Bacteriology UB) ........ $.......37 $46Animkrobial Agents and Chemotherapy (AA) $29 $36Applied and Environmental Microbiology (AE) $29 $36Intemational Joumal of Systematic
Bacteriology (IJ) ................ $.......18 $18Journal of Virology (V) .......... ........ $37 $44Joumal of Clinical Microbiology UC) ...... $28 $36Microbiological Reviews (MR) ....... $.....16 $20Infection and Immunity (IA) ....... $......37 $44Molecular and Cellular Biology (CB) .....$.22 $26
2. Membership Fee (includes ASM News) .........$ 9.003. Total dues and journals from lines
1 and 2 (MINIMUM PAYMENT $50) ......11. 0 Check this block if you prefer to receive only ASM News and
remit $50.RATES ARE FOR 1983 ONLY
AAC Please enclose payment with application.Prices are listed in U.S. dollars. Due to currency exchange difficulties and cost, foreign applicants in countries except Canada must remit in U.S.dollars by check or draft payable to ASM through a U.S. bank. Applicants from Canada may use checks drawn on Canadian banks, but remittancemust be made in U.S. dollars.
University MicrofilmsInternational
Please send additional informationfor _
(name of publication)NameInstitution_--__ _-___- ____Street_ __City --State Zip . _
300 North Zeeb RoadDept. PR.Ann Arbor. Mi. 48106USA.
30-32 Mortimer StreetDept. P. R.London WIN 7RAEngland
