NAME - Imperial College London Adnan Custo… · Web view1. NAME . Adnan Custovic. DATE OF BIRTH. 25th November 1960. ADDRESS. 4 Spencer Road. London, W3 6DN. G. MC Registration

Adnan Custovic MSc DM MD PhD FRCP

CURRICULUM VITAE

http://www.imperial.ac.uk/people/a.custovic

ORCID ID: orcid.org/0000-0001-5218-7071Scopus Author ID: 7006755479

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Contents

A. PERSONAL INFORMATION 3

1. Name 3

2. Education: schools and universities attended 3

3. Qualifications 4

4. Medals and honours 4

5. Present appointment 6

6. Previous employment and appointments held 6

7. Visiting appointments / secondments 6

B. RESEARCH CONTRIBUTION 7

1. Publications 7

Citations 7

List of peer reviewed publications 7

Original articles in Academic Journals 7

Review Articles in Academic Journals 24

Editorials in Academic Journals 32

Authored books 34

Book chapters 34

Academic journal letters

Conference contributions, refereed 36

2. Details of grants awarded 38

3. Other research achievements 42

Academic invitations for presentations at major international or national meetings 42

Editorship 57

4. Supervision of research students 58

5. Organization, promotion and management of research 60

Research projects and collaborations 61

6. Clinical responsibilities 65

C. OTHER EVIDENCE OF ACADEMIC AND PROFESSIONAL STANDING 661. Professional advisory or consultancy work in local, national or international arena 66

2. Offices held in a learned society or professional body 66

3. Other public service in a professional capacity 67

4. Lead organisational roles in national or international professional conferences 68

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D. TEACHING AND LEARNING 69

1. Current and previous teaching duties, undergraduate, professional and postgraduate 69

2. Innovative work and development of curriculum 71

3. Results of external assessments of teaching ability 71

E. LEADERSHIP AND/OR MANAGEMENT ROLES 72

1. Internal 72

2. External 72

F. KNOWLEDGE AND TECHNOLOGY TRANSFER 731. Details of how research discovery or innovation has been adopted by industry 73

2. Patents filed and approved 73

3. Consultancy activity in the corporate sector 73

4. Other appointments/engagements in the business community 73

5. Evidence of the successful application of scholarly activity 74

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A. PERSONAL INFORMATION

1. NAME Adnan Custovic

DATE OF BIRTH 25th November 1960

ADDRESS 4 Spencer RoadLondon, W3 6DN

GMC REGISTRATION Full, Registration No 4346320 Specialist Register - Allergy

NATIONALITY British

MARITAL STATUS Married

CHILDREN 2

2. EDUCATION: SCHOOLS AND UNIVERSITIES ATTENDED

1967-1975 Primary School (PS “Miljenko Cvitkovic”, Sarajevo)1975-1979 Grammar School (2nd Grammar School, Sarajevo)

AWARDS1975 The Best Pupil of Generation: Primary education1979 Gold Medal: Exceptional results in Grammar School

UNDERGRADUATE MEDICAL EDUCATION1979-1985 The Faculty of Medicine, University of Sarajevo

UNDERGRADUATE AWARDS1980, 1981, 1982, 1983 Distinction Medal for each study year 1984 Distinction Award and Medal for Medicine and Surgery1985 Distinction Award for overall results1983, 1985 First Prize for the student research project 1984 Diploma for the best student research project

POSTGRADUATE MEDICAL EDUCATION1986-1988 MSc Course “Experimental Medicine”; University of Sarajevo1992 Specialist Short Course “Respiratory Disease in Children”:

Royal Postgraduate Medical School London1992 Advanced Postgraduate Course in Paediatrics: The University

of Manchester

POSTGRADUATE AWARDS1991 The British Council Fellowship1995 The UCB Institute of Allergy Award for the abstract presented

at the AAAAI Meeting 1995 The British Lung Foundation Travel Fellowship for the

American Thoracic Society Meeting 1995

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1997 BSACI Travel Award for the AAAAI Annual Conference 1997 GlaxoWellcome Travel Award for the American Thoracic

Society Annual Conference 1998 American Academy of Allergy Asthma and Immunology

International Travel Grant to the AAAAI Annual Meeting

3. QUALIFICATIONS: ACADEMIC AND PROFESSIONAL 1985 University of Sarajevo (Doctor of Medicine; BSc MB ChB

equivalent) The Faculty of Medicine, University of Sarajevo

1991 M.Sc. in Experimental Medicine: Thesis “Exercise-induced bronchospasm as an Indicator of Bronchial Hyper-responsiveness in Atopic Children”, The University of Sarajevo

1996 M.D.: Thesis “Indoor Allergens and Asthma”, The University of Manchester

2000 Ph.D.: Thesis “Asthma: Sensitisation to Indoor Allergens and Primary Prevention in Infancy”, The University of Manchester

2006 MRCP (Hons)

2008 FRCP

2010 European Accreditation in Paediatric Allergy

4. MEDALS AND HONOURS

2019 Membership of the Academy of Sciences and Arts of Bosnia and Herzegovina

2015 European Respiratory Society Gold Medal in Asthma

2013 British Society for Allergy and Clinical Immunology William Frankland Award in recognition of outstanding contribution to the development of clinical allergy in the UK

2013 International Congress of Paediatric Pulmonology: President’s award for distinguished achievements in the understanding of asthma and allergies in children

2013 Indian Academy of Allergy Medal Oration

2012 Researcher/Research Team of the Year University Hospital of South Manchester

1996 Gold Medal: MD Thesis - University of Manchester

Named and keynote lecture

2019 Conference Internationale du Congress Francophone d’allergologie: Subtypes of childhood asthma/allergies and developmental patterns of lung functions, Paris, 18 April 2019

2019 Honorary LURN Lecture: Interplay between infection and inflammation; The 16th Lund University Respiratory Network (LURN) Conference March 22, 2019, Ystad Saltsjöbad

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2018 Cas Motala Lecture: Atopic march Joint congress of South African Paediatric Association and South African Allergy Society, Cape Town, 1 September 2018

2017 Keynote Lecture: “Primary and secondary prevention of asthma”; Connecting Asthma Care Australasian Conference, Adelaide, 16 October 2017

2016 Ann Woolcock Lecture: “The many faces of asthma in childhood and adolescence: Can we personalise treatment?” Woolcock Institute of Medical Research, Sydney, Australia. 28 October 2016

2016 Leonard Noon and John Freeman Honorary Lecture: “Can biomarkers improve prevention of asthma & allergic disease?” IX World Asthma, Allergy and COPD Forum, Saint Petersburg, 02 July 2016

2014 Keynote Lecture: “Asthma in childhood and adolescence: From endotype to adaptive personalization” Nemacolin International Asthma Conference, Farmington, Pennsylvania, USA, 01 November 2014

2013 Keynote Speaker: “Asthma, Allergies and Atopy - What is the Association?” The International Congress on Paediatric Pulmonology Valencia, 29 June 2013

2013 Alain De Weck Memorial Lecture: “Allergens and asthma” VI World Asthma and COPD Forum, London, 28 April 2013

2013 Cas Motala Memorial Lecture: “Is asthma an allergic disease?” Allergy Society of South Africa, Sun City, 7 June 2013

2012 22nd James Hutchison's Memorial Lecture: “Asthma and allergy: Nature or nurture” The Hong Kong Paediatric Society

2011 Priscilla Piper Lecture: “Gene-environment interactions in the development of asthma” The Royal Society of Medicine

2007 Caspar Weinberg Lecture: “Gene-environment interactions in the development of asthma and allergic sensitization” Allergy Society of South Africa

2007 European Respiratory Society Web-based Live lecture: “Too dirty or too clean: Why are asthma and allergies increasing?”

2006 Japanese Society of Paediatric Allergy and Clinical Immunology Special Invited Lecture: “Risk factors for asthma exacerbations”

2002 The Royal Institution of Great Britain Lecture: “Cleanliness - a healthy obsession?”

Honorary Membership of Learned Societies

2016 World Immunopathology Organisation

2007 The Allergy Society of South Africa

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5. PRESENT APPOINTMENT S

15/09/2015-present Professor of Paediatric Allergy, Imperial College London

Honorary Consultant Paediatric Allergist – Imperial College Healthcare NHS Trust (St Mary’s hospital)

01/12/2017-present Honorary Consultant Paediatric Allergist - Royal Brompton & Harefield NHS Foundation Trust.

6. PREVIOUS EMPLOYMENT AND APPOINTMENTS HELD

01/06/05-14/09/15 Professor of Allergy, The University of Manchester

01/06/15-14/09/15 Honorary Consultant Allergist – Central Manchester University Hospitals NHS Foundation Trust

01/06/98-31/05/15 Honorary Consultant Allergist - University Hospital of South Manchester NHS Foundation Trust

01/06/02-31/12/04 The National Asthma Campaign Professorial Senior Clinical Research Fellow: The University of Manchester

01/01/00-31/05/02 The National Asthma Campaign Senior Clinical Research Fellow and Reader in Respiratory Medicine and Allergy: The University of Manchester

01/06/98-31/12/99 Senior Clinical Research Fellow: South Manchester University Hospital NHS Trust

01/01/95-31/05/98 Specialist Registrar in Allergy: Wythenshawe Hospital Manchester and Manchester Royal Infirmary

01/01/93-31/12/94 Research Registrar: North West Lung Centre, Wythenshawe Hospital, Manchester

14/01/92-31/12/92 The British Council Research Fellow, The Duchess of York Children's Hospital, Manchester

Jan 1988-Jan 1992 Specialist Training in Paediatrics: University Children's Hospital, Sarajevo

July 1987-Jan 1988 Senior House Officer in Paediatrics: University Children's Hospital, Sarajevo

Dec 1986-June 1987 House Officer, Surgery: University Surgical and Trauma Centre, Sarajevo

Dec 1985-Nov 1986 Resident Medical Officer (National Army Service): Accident and Emergency and Medical Centre, Mostar

June-December 1985 House Officer, Medicine: University Medical Centre Sarajevo

7. VISITING APPOINTMENTS / SECONDMENTS

2018 Visiting Wong Hock Boon Professor in Paediatrics National University of Singapore

01/01/2018-31/12/2022 Honorary Professor: Department of Paediatrics and Child Health, University of Cape Town, South Africa

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15/09/2015-14/09/2021 Honorary Professor: Division of Informatics, Imaging and Data Sciences, School of Health Sciences, The University of Manchester

2008-present Visiting Professor: University of Zagreb, Croatia

B. RESEARCH CONTRIBUTION

1. PUBLICATIONS

Citationsh-index 90; total citations >37,000 (Google scholar)http://scholar.google.co.uk/citations?hl=en&user=W3WEuQwAAAAJ

h-index 73; total citations >21,000 (Scopus and Thomson Reuters Web of Science)ORCID ID: orcid.org/ 0000-0001-5218-7071 Scopus Author ID: 7006755479 Web of Science ResearcherID: A-2435-2012 Loop profile: 364144

LIST OF PEER REVIEWED PUBLICATIONS

Original Articles in Academic Journals

1. Deliu M, Fontanella S, Haider S, Sperrin M, Geifman N, Murray C, Simpson A, Custovic A. Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes. Clin Exp Allergy. 2019 Dec 25. doi: 10.1111/cea.13553. [Epub ahead of print] PMID: 31876035

2. Bédard A, Antó JM, Fonseca JA, Arnavielhe S, Bachert C, Bedbrook A, Bindslev-Jensen C, Bosnic-Anticevich S, Cardona V, Cruz AA, Fokkens WJ, Garcia-Aymerich J, Hellings PW, Ivancevich JC, Klimek L, Kuna P, Kvedariene V, Larenas-Linnemann D, Melén E, Monti R, Mösges R, Mullol J, Papadopoulos NG, Pham-Thi N, Samolinski B, V Tomazic P, Toppila-Salmi S, Ventura MT, Yorgancioglu A, Bousquet J, Pfaar O, Basagaña X; MASK study group. Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air® App. Allergy. 2020 Jan 29. doi: 10.1111/all.14204. [Epub ahead of print] PMID: 31995656

3. Thyssen JP, Ahluwalia TS, Paternoster L, Ballardini N, Bergström A, Melén E, Chawes B, Stokholm J, Hourihane JO, O'Sullivan DM, Bager P, Maelbye M, Bustamante M, Torrent M, Esplugues A, Duijts L, Hu C, Elbert NJ, Pasmans SGMA, Nijsten TEC, von Berg A, Standl M, Schikowski T, Herberth G, Heinrich J, Lee YA, Marenholz I, Lau S, Curtin JA, Simpson A, Custovic A, Pennell CE, Wang CA, Holt PG, Bisgaard H, Bønnelykke K. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis. Allergy. 2019 Dec 26. doi: 10.1111/all.14162. [Epub ahead of print] PMID: 31877228

4. Simpson A, Brough HA, Haider S, Belgrave D, Murray CS, Custovic A. Early-life inhalant allergen exposure, filaggrin genotype and the development of sensitization from infancy to adolescence. J Allergy Clin Immunol. 2019 Oct 17. pii: S0091-6749(19)31323-5. doi: 0.1016/j.jaci.2019.08.041. [Epub ahead of print] PMID: 31629803

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5. Clark H, Granell R, Curtin JA, Belgrave D, Simpson A, Murray C, Henderson AJ, Custovic A, Paternoster L. Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis. Clin Exp Allergy. 2019 Nov;49(11):1475-1486. doi: 10.1111/cea.13485. Epub 2019 Oct 15. PMID: 31441980

6. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV, Grant SFA; Early Growth Genetics Consortium. Hum Mol Genet. 2019 Oct 1;28(19):3327-3338. doi: 10.1093/hmg/ddz161.

7. Powell EA, Fontanella S, Boakes E, Belgrave D, Shaw AG, Cornwell E, Fernandez-Crespo R, Fink CG, Custovic A, Kroll JS. Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort. EBioMedicine. 2019 Aug;46:486-498. doi: 10.1016/j.ebiom.2019.07.034. Epub 2019 Jul 25. PMID: 31353293

8. Nakamura T, Haider S, Colicino S, Murray CS, Holloway J, Simpson A, Cullinan P, Custovic A; STELAR investigators. Different definitions of atopic dermatitis: Impact on prevalence estimates and associated risk factors. Br J Dermatol. 2019 Dec;181(6):1272-1279. doi: 10.1111/bjd.17853. Epub 2019 Jun 26.

9. Oksel C, Granell R, Haider S, Fontanella S, Simpson A, Turner S, Devereux G, Arshad SH, Murray CS, Roberts G, Holloway JW, Cullinan P, Henderson J, Custovic A; STELAR and Breathing Together investigators. Distinguishing wheezing phenotypes from infancy to adolescence: A pooled analysis of five birth cohorts. Ann Am Thorac Soc. 2019 Jul;16(7):868-876. doi: 10.1513/AnnalsATS.201811-837OC. PMID: 30888842

10. Gaertner VD, Michel S, Curtin JA, Pulkkinen V, Acevedo N, Söderhäll C, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Pershagen G, Melén E, Simpson A, Custovic A, Kere J, Kabesch M. Nocturnal asthma is affected by genetic interactions between RORA and NPSR1. Pediatr Pulmonol. 2019 Jun;54(6):847-857. doi: 10.1002/ppul.24292. PMID: 30927345

11. Oksel C, Granell R, Mahmoud O, Custovic A, Henderson AJ; STELAR; Breathing Together investigators. Causes of variability in latent phenotypes of childhood wheeze. J Allergy Clin Immunol. 2019 May;143(5):1783-1790.e11 doi: 10.1016/j.jaci.2018.10.059. [Epub ahead of print]

12. Colicino S, Munblit D, Minelli C, Custovic A, Cullinan P. Validation of childhood asthma predictive tools: a systematic review. Clin Exp Allergy. 2019 Apr;49(4):410-418. doi: 10.1111/cea.13336 PMID: 30657220

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13. Menditto E, Costa E, Midão L et al; MASK group. Adherence to treatment in allergic rhinitis using mobile technology. The MASK study. Clin Exp Allergy. 2019 Apr;49(4):442-460. doi: 10.1111/cea.13333.

14. Middeldorp CM, Felix JF, Mahajan A; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium, McCarthy MI. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. 2019 Mar;34(3):279-300. doi: 10.1007/s10654-019-00502-9. PMID:30887376

15. Wang R, Simpson A, Custovic A, Foden P, Belgrave D, Murray CS. Individual risk assessment tool for school age asthma prediction in UK birth cohort. Clin Exp Allergy. 2019 Mar;49(3):292-298. doi: 10.1111/cea.13319.PMID: 30447026

16. Mahmoud O, Granell R, Tilling K, Minelli C, Garcia-Aymerich J, Holloway JW, Custovic A, Jarvis D, Sterne J, Henderson J. Association of height growth in puberty with lung function: A longitudinal study. Am J Respir Crit Care Med. 2018 Dec 15;198(12):1539-48 doi: 10.1164/rccm.201802-0274OC. [Epub ahead of print]

17. Fontanella S, Frainay C, Murray CS, Simpson A, Custovic A. Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: A cross-sectional analysis within a population-based birth cohort. PLoS Med. 2018 Nov 13;15(11):e1002691. doi: 10.1371/journal.pmed.1002691.

18. Tang HH, Teo SM, Belgrave DC, Evans MD, Jackson DJ, Brozynska M, Kusel MM, Johnston SL, Gern JE, Lemanske RF, Simpson A, Custovic A, Sly PD, Holt PG, Holt KE, Inouye M. Trajectories of childhood immune development and respiratory health relevant to asthma and allergy. Elife. 2018 Oct 15;7. pii: e35856. doi: 10.7554/eLife.35856. [Epub ahead of print] PMID: 30320550

19. Howard R, Belgrave D, Papastamoulis P, Simpson A, Rattray M, Custovic A. Evolution of IgE responses to multiple allergen components throughout childhood. J Allergy Clin Immunol. 2018 Oct;142(4):1322-1330. doi: 10.1016/j.jaci.2017.11.064. PMID: 29428391

20. Jolliffe DA, Greiller CL, Mein CA, Hoti M, Bakhsoliani E, Telcian AG, Simpson A, Barnes NC, Curtin JA, Custovic A, Johnston SL, Griffiths CJ, Walton RT, Martineau AR. Vitamin D receptor genotype influences risk of upper respiratory infection. Br J Nutr. 2018 Oct;120(8):891-900. doi: 10.1017/S000711451800209X. PMID:30132432

21. Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A. Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study. Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018. PMID: 30191183

22. Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N; 23andMe Research Team; AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Antó JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonàs-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S,

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Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 Aug;50(8):1072-1080. doi: 10.1038/s41588-018-0157-1. Epub 2018 Jul 16.

23. Samreth D et al for the MASK study group. Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study. World Allergy Organ J. 2018 Jul 16;11(1):15. doi: 10.1186/s40413-018-0194-3. eCollection 2018. PMID: 30061979

24. Belgrave DCM, Granell R, Turner SW, Curtin JA, Buchan IE, Le Souëf PN, Simpson A, Henderson AJ, Custovic A. Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies. Lancet Respir Med. 2018 Jul;6(7):526-534. doi: 10.1016/S2213-2600(18)30099-7. Epub 2018 Apr 5.PMID:29628377

25. Bahri R, Custovic A, Korosec P, Tsoumani M, Barron M, Wu J, Sayers R, Weimann A, Ruiz-Garcia M, Patel N, Robb A, Shamji MH, Fontanella S, Silar M, Mills ENC, Simpson A, Turner PJ, Bulfone-Paus S. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis. J Allergy Clin Immunol. 2018 Aug;142(2):485-496.e16. doi: 10.1016/j.jaci.2018.01.043. Epub 2018 Mar 5. PMID: 29518421.

26. Custovic A, Belgrave D, Lin L, Bakhsoliani E, Telcian AG, Solari R, Murray CS, Walton RP, Curtin J, Edwards MR, Simpson A, Rattray M, Johnston SL. Cytokine responses to rhinovirus and development of asthma, allergic sensitization and respiratory infections during childhood. Am J Respir Crit Care Med. 2018;197(10):1265-1274. doi: 10.1164/rccm.201708-1762OC.

27. Ziyab AH, Hankinson J, Ewart S, Schauberger E, Kopec-Harding K, Zhang H, Custovic A, Arshad H, Simpson A, Karmaus WJ. Epistasis between FLG and IL4R genes on the risk of allergic sensitization: Results from two population-based birth cohort studies. Sci Rep. 2018 Feb 19;8(1):3221. doi: 10.1038/s41598-018-21459-x.

28. Gore C, Gore RB, Fontanella S, Haider S, Custovic A. Temperature-controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open-label, proof-of-concept study. Clin Exp Allergy. 2018;48(5):594-603. doi: 10.1111/cea.13105.

29. Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T,

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Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7.

30. Ihuoma H, Belgrave DC, Murray CS, Foden P, Simpson A, Custovic A. Cat ownership, cat allergen exposure, and trajectories of sensitization and asthma throughout childhood. J Allergy Clin Immunol. 2018;141(2):820-822.e72017. doi: 10.1016/j.jaci.2017.09.030.

31. Deliu M, Yavuz TS, Sperrin M, Belgrave D, Sahiner UM, Sackesen C, Kalayci O, Custovic A. Features of asthma which provide meaningful insights for understanding the disease heterogeneity. Clin Exp Allergy. 2018;48(1):39-47. doi: 10.1111/cea.13014.

32. Valovirta E, Petersen TH, Piotrowska T, Laursen MK, Andersen JS, Sørensen HF, Klink R; GAP investigators. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018 Feb;141(2):529-538.e13. doi: 10.1016/j.jaci.2017.06.014. Epub 2017 Jul 6.

33. Bousquet J, Agache I, Aliberti MR, Angles R, Annesi-Maesano I, Anto JM, Arnavielhe S, Asayag E, Bacci E, Bedbrook A, Bachert C, Baroni I, Barreto BA, Bedolla-Barajas M, Bergmann KC, Bertorello L, Bewick M, Bieber T, Birov S, Bindslev-Jensen C, Blua A, Bochenska Marciniak M, Bogus-Buczynska I, Bosnic-Anticevich S, Bosse I, Bourret R, Bucca C, Buonaiuto R, Burguete Cabanas MT, Caillaud D, Caimmi DP, Caiazza D, Camargos P, Canfora G, Cardona V, Carriazo AM, Cartier C, Castellano G, Chavannes NH, Cecci L, Ciaravolo MM, Cingi C, Ciceran A, Colas L, Colgan E, Coll J, Conforti D, Correia de Sousa J, Cortés-Grimaldo RM, Corti F, Costa E, Courbis AL, Cousein E, Cruz AA, Custovic A, et al. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project). Allergy. 2018 Jan;73(1):77-92. doi: 10.1111/all.13218. Epub 2017 Aug 24.

34. Wickman M, Lupinek C, Andersson N, Belgrave D, Asarnoj A, Benet M, Pinart M, Wieser S, Garcia-Aymerich J, Baar A, Pershagen G, Simpson A, Kull I, Bergström A, Melén E, Hamsten C1, Antó JM, Bousquet J, Custovic A, Valenta R, van Hage M. Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence. EBioMedicine. 2017;26:91-99. doi: 10.1016/j.ebiom.2017.11.009.

35. Belgrave D, Cassidy R, Stamate D, Fleming L, Bush A, Saglani S, Custovic A. Predictive modelling strategies to understand heterogeneous manifestations of asthma in early life. 2017 16th IEEE International Conference on Machine Learning and Applications (ICMLA), Cancun, 2017, pp. 68-75. doi: 10.1109/ICMLA.2017.0-176

36. Caimmi D, Baiz N, Tanno LK, Demoly P, Arnavielhe S, Murray R, Bedbrook A, Bergmann KC, De Vries G, Fokkens WJ, Fonseca J, Haahtela T, Keil T, Kuna P, Mullol J, Papadopoulos N, Passalacqua G, Samolinski B, Tomazic PV, Valiulis A, van Eerd M, Wickman M, Annesi-Maesano I, Bousquet J; MASK Study Group. Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control. Clin Exp Allergy. 2017;47(12):1526-1533. doi: 10.1111/cea.13025.

37. Murray C, Foden P, Lowe L, Durrington H, Custovic A, Simpson A. Diagnosis of asthma in symptomatic children based on measures of lung function: an analysis of data from a population-based birth cohort study. Lancet Child Adolesc Health. 2017;1(2):114-123. doi: 10.1016/S2352-4642(17)30008-1.

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38. Korosec P, Turner PJ, Silar M, Kopac P, Kosnik M, Gibbs BF, Shamji MH, Custovic A, Rijavec M. Basophils, high-affinity IgE receptors and CCL2 in human anaphylaxis. J Allergy Clin Immunol. 2017;140(3):750-758.e15. doi: 10.1016/j.jaci.2016.12.989.

39. Kreiner E, Waage J, Standl M, Brix S, Pers TH, Couto Alves A, Warrington NM, Tiesler CM, Fuertes E, Franke L, Hirschhorn JN, James A, Simpson A, Tung JY, Koppelman GH, Postma DS, Pennell CE, Jarvelin MR, Custovic A, Timpson N, Ferreira MA, Strachan DP, Henderson J, Hinds D, Bisgaard H, Bønnelykke K. Shared genetic variants suggest common pathways in allergy and autoimmune diseases. J Allergy Clin Immunol. 2017;140(3):771-781. doi: 10.1016/j.jaci.2016.10.055.

40. Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing severe asthma exacerbations in children: A randomised trial of mite impermeable bedcovers. Am J Respir Crit Care Med. 2017;196(2):150-158. doi: 10.1164/rccm.201609-1966OC.

41. DeVries A, Wlasiuk G, Miller SJ, Bosco A, Stern DA, Lohman IC, Rothers J, Jones AC, Nicodemus-Johnson J, Vasquez MM, Curtin JA, Simpson A, Custovic A, Jackson DJ, Gern JE, Lemanske RF Jr, Guerra S, Wright AL, Ober C, Halonen M, Vercelli D. Epigenome-wide analysis lnks SMAD3 methylation at birth to asthma in children of asthmatic mothers. J Allergy Clin Immunol. 2017;140(2):534-542. doi: 10.1016/j.jaci.2016.10.041.

42. Mohammad HR, Belgrave D, Kopec Harding K, Murray CS, Simpson A, Custovic A. Age, sex, and the association between skin test responses and IgE titres with asthma. Pediatr Allergy Immunol. 2016;27(3):313-9. doi: 10.1111/pai.12534.

43. Downs ML, Simpson A, Custovic A, Semic-Jusufagic A, Bartra J, Fernandez-Rivas M, Taylor SL, Baumert JL, Mills EN. Insoluble and soluble roasted walnut proteins retain antibody reactivity. Food Chem 2016;194:1013-21. doi: 10.1016/j.foodchem.2015.08.119

44. Holt PG, Strickland D, Bosco A, Belgrave D, Hales B, Simpson A, Hollams E, Holt B, Kusel M, Ahlstedt S, Sly PD, Custovic A. Distinguishing benign from pathologic TH2 immunity in atopic children. J Allergy Clin Immunol. 2016 Feb;137(2):379-87. doi: 10.1016/j.jaci.2015.08.044. Epub 2015 Oct 27.

45. Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, Franks S, Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T, Curtin JA, Vioque J, Ahluwalia TS, Myhre R, Price TS, Vilor-Tejedor N, Yengo L, Grarup N, Ntalla I, Ang W, Atalay M, Bisgaard H, Blakemore AI, Bonnefond A, Carstensen L; Bone Mineral Density in Childhood Study (BMDCS) Consortium; Early Genetics and Lifecourse Epidemiology (EAGLE) consortium, Eriksson J, Flexeder C, Franke L, Geller F, Geserick M, Hartikainen AL, Haworth CM, Hirschhorn JN, Hofman A, Holm JC, Horikoshi M, Hottenga JJ, Huang J, Kadarmideen HN, Kähönen M, Kiess W, Lakka HM, Lakka TA, Lewin AM, Liang L, Lyytikäinen LP, Ma B, Magnus P, McCormack SE, McMahon G, Mentch FD, Middeldorp CM, Murray CS, Pahkala K, Pers TH, Pfäffle R, Postma DS, Power C, Simpson A, Sengpiel V, Tiesler CM, Torrent M, Uitterlinden AG, van Meurs JB, Vinding R, Waage J, Wardle J, Zeggini E, Zemel BS, Dedoussis GV, Pedersen O, Froguel P, Sunyer J, Plomin R, Jacobsson B, Hansen T, Gonzalez JR, Custovic A, Raitakari OT, Pennell CE, Widén E, Boomsma DI, Koppelman GH, Sebert S, Järvelin MR, Hyppönen E, McCarthy MI, Lindi V, Harri N, Körner A, Bønnelykke K, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Smith GD, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW; Early Growth Genetics (EGG) Consortium; Bone Mineral Density in Childhood Study BMDCS Consortium. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet. 2016;25(2):389-403. doi: 10.1093/hmg/ddv472.

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46. Custovic A, Sonntag HJ, Buchan IE, Belgrave D, Simpson A, Prosperi MC. Evolution pathways of IgE responses to grass and mite allergens throughout childhood. J Allergy Clin Immunol. 2015;136(6):1645-1652.e8. doi: 10.1016/j.jaci.2015.03.041.

47. EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium; Australian Asthma Genetics Consortium (AAGC); Australian Asthma Genetics Consortium AAGC. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 2015;47(12):1449-56. doi: 10.1038/ng.3424. Epub 2015 Oct 19.

48. Wu J, Prosperi MC, Simpson A, Hollams EM, Sly PD, Custovic A, Holt PG. Relationship between cytokine expression patterns and clinical outcomes: Two population-based birth cohorts. Clin Exp Allergy. 2015;45(12):1801-11. doi: 10.1111/cea.12579.

49. Simpson A, Lazic N, Belgrave DC, Johnson P, Bishop C, Mills C, Custovic A. Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years. J Allergy Clin Immunol. 2015;136(5):1224-31. doi: 10.1016/j.jaci.2015.03.027. Epub 2015 Apr 30.

50. Guerra S, Halonen M, Vasquez MM, Spangenberg A, Stern DA, Morgan WJ, Wright AL, Lavi I, Tarès L, Carsin AE, Dobaño C, Barreiro E, Zock JP, Martínez-Moratalla J, Urrutia I, Sunyer J, Keidel D, Imboden M, Probst-Hensch N, Hallberg J, Melén E, Wickman M, Bousquet J, Belgrave DC, Simpson A, Custovic A, Antó JM, Martinez FD. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015;3(8):613-20. doi: 10.1016/S2213-2600(15)00196-4. Epub 2015 Jul 6.

51. Custovic A, Ainsworth J, Arshad H, Bishop C, Buchan I, Cullinan P, Devereux G, Henderson AJ, Holloway JW, Roberts G, Turner G, Woodcock A, Simpson A. The Study Team for Early Life Asthma Research (STELAR) consortium “Asthma e-lab”: Team science bringing data, methods and investigators together. Thorax. 2015;70:799–801 Thoraxjnl-2015-206781. doi: 10.1136/thoraxjnl-2015-206781.

52. Mölter A, Simpson A, Berdel D, Brunekreef B, Custovic A, Cyrys J, de Jongste J, de Vocht F, Fuertes E, Gehring U, Gruzieva O, Heinrich J, Hoek G, Hoffmann B, Klümper C, Korek M, Kuhlbusch TA, Lindley S, Postma D, Tischer C, Wijga A, Pershagen G, Agius R. A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project. Eur Respir J 2015;45(3):610-24. doi: 10.1183/09031936.00083614.

53. van der Valk RJ, Kreiner-Møller E, Kooijman MN, Guxens M, Stergiakouli E, Sääf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Körner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkänen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Smith GD, Bergström A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M; Early Genetics & Lifecourse Epidemiology (EAGLE) Consortium, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CM, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen AL, Keinanen-Kiukaanniemi S, Lewin A, Da Silva Couto Alves A, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikäinen LP, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw SM, Holloway JW, Melén E, Grant SF, Feenstra B, Lowe WL, Widén E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin MR, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, McCarthy MI, Frayling TM,

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Sunyer J, Timpson NJ, Rivadeneira F, Bønnelykke K, Jaddoe VW; for the Early Growth Genetics (EGG) Consortium. A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet. 2015;24(4):1155-68. doi: 10.1093/hmg/ddu510.

54. Gore RB, Boyle RJ, Gore C, Custovic A, Hanna H, Svensson P, Warner JO. Effect of a novel temperature-controlled laminar airflow device on personal breathing zone aeroallergen exposure. Indoor Air. 2015;25(1):36-44. doi: 10.1111/ina.12122.

55. Sahiner UM, Jusufagic AS, Curtin JA, Birben E, Belgrave D, Sackesen C, Simpson A, Yavuz TS, Akdis CA, Custovic A, Kalayci O. Polymorphisms of endotoxin pathway and endotoxin exposure: in-vitro IgE synthesis and replication in a birth cohort. Allergy. 2014;69(12):1648-58. doi: 10.1111/all.12504.PMID: 25102764

56. Wang R, Custovic A, Simpson A, Belgrave D, Lowe L, Murray CS. Differing associations of BMI and body fat with asthma and lung function in children. Pediatr Pulmonol. 2014;49(11):1049-57. doi: 10.1002/ppul.22927.

57. Deliu M, Belgrave D, Simpson A, Murray CS, Kerry G, Custovic A. Impact of rhinitis on asthma severity in school-age children. Allergy. 2014;69(11):1515-1521. doi: 10.1111/all.12467

58. Kljaic-Bukvic B, Blekic M, Aberle N, Curtin JA, Hankinson J, Semic-Jusufagic A, Belgrave D, Simpson A, Custovic A. Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations. Pediatr Allergy Immunol 2014 2014;25(6):552-7. doi: 10.1111/pai.12258.

59. Patel S, Custovic A, Smith JA, Simpson A, Kerry G, Murray CS. Cross-sectional association of dietary patterns with asthma and atopic sensitisation in childhood - in a cohort study. Pediatr Allergy Immunol. 2014;25(6):565-71. doi: 10.1111/pai.12276.

60. Belgrave DCM, Granell R, Simpson A, Guiver J, Bishop C, Buchan I, Henderson AJ, Custovic A. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med. 2014 21;11(10):e1001748. doi: 10.1371/journal.pmed.1001748.

61. Brough HA, Simpson A, Makinson K, Hankinson J, Brown S, Douiri A, Belgrave DC, Penagos M, Stephens AC, McLean WH, Turcanu V, Nicolaou N, Custovic A, Lack G. Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014;134(4):867-875.e1. doi: 10.1016/j.jaci.2014.08.011.

62. Eeftens M, Hoek G, Gruzieva O, Mölter A, Agius R, Beelen R, Brunekreef B, Custovic A, Cyrys J, Fuertes E, Heinrich J, Hoffmann B, de Hoogh K, Jedynska A, Keuken M, Klümper C, Kooter I, Krämer U, Korek M, Koppelman GH, Kuhlbusch TA, Simpson A, Smit HA, Tsai MY, Wang M, Wolf K, Pershagen G, Gehring U. Elemental composition of particulate matter and the association with lung function. Epidemiology. 2014;25(5):648-57. doi: 10.1097/EDE.0000000000000136

63. Semic-Jusufagic A, Belgrave D, Pickles A, Telcian AG, Bakhsoliani E, Sykes A, Simpson A, Johnston SL, Custovic A. The association of early-life antibiotic prescription with asthma exacerbations, impaired antiviral immunity and genetic variants in 17q21: a population-based birth cohort study. Lancet Respir Med. 2014;2(8):621-30. doi: 10.1016/S2213-2600(14)70096-7.

64. van der Valk RJP, Duijts L, Timpson N, Salam MT, Standl M, Curtin JA, Genuneit J, Kerhof M, Kreiner-Møller E, Cáceres A, Gref A, Liang L, Taal HR, Bouzigon E, Demenais F, Nadif R, Ober C, Thompson EE, Estrada K, Hofman A, Uitterlinden AG, van Duijn C, Rivadeneira F, Li X, Eckel SP, Berhane K, Gauderman WJ, Granell R,

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Evans DM, St Pourcain B, McArdle W, Kemp JP, Davey Smith G, Tiesler CMT, Flexeder C, Simpson A, Murray CS, Fuchs O, Postma DS, Bønnelykke K, Torrent M, Andersson M, Sleiman P, Hakonarson H, Cookson WO, Moffatt MF, Paternoster L, Melén E, Sunyer J, Bisgaard H, Koppelman GH, Ege M, Custovic A, Heinrich J, Gilliland FD, Henderson AJ, Jaddoe VWV, de Jongste JC for the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium. Fractional exhaled nitric oxide in childhood is associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014;134(1):46-55. doi: 10.1016/j.jaci.2013.08.053.

65. Prosperi MCF, Marinho S, Simpson A, Custovic A, Buchan IE. Predicting phenotypes of asthma and eczema with machine learning. BMC Med Genomics. 2014;7 Suppl 1:S7. doi: 10.1186/1755-8794-7-S1-S7.

66. Belgrave DCM, Buchan I, Bishop C, Lowe L, Simpson A, Custovic A. Trajectories of lung function during childhood. Am J Respir Crit Care Med. 2014;189(9):1101-9. doi: 10.1164/rccm.201309-1700OC.

67. Prosperi MCF, Belgrave D, Buchan I, Simpson A, Custovic A. Challenges in interpreting allergen microarrays in relation to clinical symptoms: a machine learning approach. Pediatr Allergy Immunol. 2014;25(1):71-9. doi: 10.1111/pai.12139

68. Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, Juel L, Paternoster L, Flaaten R, Mølgaard A , Smart DE, Thomsen PF, Bonàs-Guarch S, Holst C, Nohr EA, Yadav R, March ME, Blicher T, Lackie PM, Jaddoe VWV, Simpson A, Holloway JW, Duijts L, Custovic A, Davies DE, Torrents D, Gupta R, Hollegaard MV, Hougaard DM, Hakonarsson H, Bisgaard H. A genome-wide association study of early childhood asthma with severe exacerbations identifies Cadherin Related Family Member 3 (CDHR3) as a novel susceptibility gene. Nat Genet. 2014;46(1):51-5. doi: 10.1038/ng.2830.

69. Mölter A, Agius R, de Vocht, Lindley S, Gerrard W, Custovic A, Simpson A. Effects of long term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort. J Epidemiol Commun H. 2014;68(1):21-8. doi: 10.1136/jech-2013-202681

70. Prosperi MCF, Sahiner UM, Belgrave D, Sackesen C, Buchan IE, Simpson A, Yavuz TS, Kalayci O, Custovic A. Challenges in identifying asthma endotypes subgroups using unsupervised statistical learning techniques. Am J Respir Crit Care Med. 2013;188(11):1303-12. doi: 10.1164/rccm.201304-0694OC.

71. Gehring U, Gruzieva O, Agius R, Beelen R, Custovic A, Cyrys J, Eeftens M, Flexeder C, Fuertes E, Heinrich J, Hoffmann B, de Jongste JC, Kerkhof M, Klümper C, Korek M, Mölter A, Schultz E, Simpson A, Sugiri D, Svartengren M, von Berg A, Wijga AH, Pershagen G, Brunekreef B. Air Pollution exposure and lung function in children – The ESCAPE project. Environ Health Perspect. 2013;121(11-12):1357-1364 PMID: 24076757

72. Mölter A, Agius RM, de Vocht F, Lindley S, Gerrard W, Lowe L, Belgrave D, Custovic A, Simpson A. Long Term Exposure to PM10 and NO2 in Association with Lung Volume and Airway Resistance in the MAAS Birth Cohort. Environ Health Perspect. 2013;121(10):1232-1238. doi: 10.1289/ehp.1205961.

73. Belgrave DC, Simpson A, Semic-Jusufagic A, Murray CS, Buchan I, Pickles A, Custovic A. Joint modeling of parentally-reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing. J Allergy Clin Immunol 2013;132(3):575-583.e12. doi: 10.1016/j.jaci.2013.05.041.

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74. Ibrahim B, Marsden P, Morris J, Smith JA, Custovic A, Nilsson M, Fowler SJ. Exhaled breath condensate metabolomic profiling by nuclear magnetic resonance spectroscopy in asthma. Allergy 2013;68(8):1050-6. doi: 10.1111/all.12211.

75. Bønnelykke K, Matheson M, Pers TH, Raquel Granell R; Strachan DP, Alves AC, Linneberg A, Curtin JA, Warrington NM, Standl M, Kerkhof M, Jonsdottir I, Kljaic-Bukvic B, Kaakinen M, Sleimann P, Thorleifsson G, Thorsteinsdottir U, Schramm K, Baltic S, Kreiner-Møller E, Simpson A, St Pourcain B; Coin L, Hui J, Walters H, Tiesler CMT, Duffy D, Jones G, AAGC, Ring SM, McArdle WL, Price L, Robertson C, Pekkanen J, Tang C, Thiering E, Montgomery G, Hartikainen AL, Dharmage S, Husemoen LL, Herder C, Kemp JP, Elliot P, James A, Waldenberger M, Abramson M, Fairfax BP, Knight JC, Gupta R, Thompson P, Holt P, Sly P, Hirschhorn JN, Blekic M, Weidinger S, Hakonarsson H, Stefansson K, Heinrich J, Postma DS, Custovic A, Pennell CE, Jarvelin MR, Koppelman GH, Timpson N, Ferreira M, Bisgaard H, Henderson AJ. Meta-analysis of genome-wide association studies identifies 10 loci influencing allergic sensitization. Nat Genet. 2013;45(8):902-6. doi: 10.1038/ng.2694.

76. Wu J, Hankinson J, Kopec-Harding K, Custovic A, Simpson A. Interaction between glutathione s-transferase variants, maternal smoking and childhood wheezing changes with age. Pediatr Allergy Immunol. 2013;24(5):501-8. doi: 10.1111/pai.12086.

77. Lazic N, Roberts G, Custovic A, Belgrave D, Bishop CM, Winn J, Curtin JA, Arshad SH, Simpson A. Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy. 2013;68(6):764-70. doi: 10.1111/all.12134.

78. Blekic M, Kljaic Bukvic B, Aberle N, Marinho S, Hankinson J, Custovic A, Simpson A. 17q12-21 and asthma: interactions with early-life environmental exposures. Ann Allergy Asthma Immunol. 2013;110(5):347-353.e2. doi: 10.1016/j.anai.2013.01.021.

79. Curtin JA, Simpson A, Belgrave D, Semic-Jusufagic A, Custovic A, Martinez FD. Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood. Clin Exp Allergy. 2013;43(3):304-11 doi: 10.1111/cea.12046.

80. Kljaic-Bukvic B, Blekic M, Simpson A, Marinho S, Curtin JA, Hankinson J, Aberle N, Custovic A. Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure. Pediatr Allergy Immunol. 2013; 24(1): 10-18. doi: 10.1111/pai.12019.

81. Patel S, Vyas A, Custovic A, Murray CS. Estimated portion sizes in a school-aged population. Public Health Nutr. 2012; 15(12): 2193-201. PMID: 22702533

82. Fernandes BN, Boyle RJ, Gore C, Simpson A, Custovic A. Food protein-induced enterocolitis syndrome can occur in adults. J Allergy Clin Immunol. 2012; 130(5):1199-1200. PMID:22835404

83. Lødrup Carlsen KC, Roll S, Carlsen KH, Mowinckel P, Wijga AH, Brunekreef B, Torrent M, Roberts G, Arshad SH, Kull I, Krämer U, von Berg A, Eller E, Høst A, Kuehni C, Spycher B, Sunyer J, Chen CM, Reich A, Asarnoj A, Puig C, Herbarth O, Mahachie John JM, Van Steen K, Willich SN, Wahn U, Lau S, Keil T; GALEN WP 1.5 ‘Birth Cohorts’ working group. Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS One. 2012;7(8):e43214

84. Bishop C, Belgrave D, Simpson A, Buchan I, Custovic A. Bayesian machine learning approaches for longitudinal latent class modelling to define wheezing phenotypes to elucidate environmental associates. Quaderni di statistica. 2012;14:25-28

85. Marinho S, Custovic A, Marsden P, Smith JA, Simpson A. 17q12-21 Variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. Ann Allergy Asthma Immunol. 2012;108(6);402–411.e9

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86. Simpson A, Custovic A, Tepper R, Graves P, Stern DA, Jones M, et al. Genetic variation in vascular endothelial growth factor-a and lung function. Am J Respir Crit Care Med. 2012;185:1197-1204. PMID: 22461367

87. Paternoster L, Standl M, Chen C, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H, Feenstra B, Sleiman PMA, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA, Groen-Blokhuis MM, Kerkhof M, Sääf A, Franke A, Ellinghaus E, Fölster-Holst R, Dermitzakis E, Montgomery SB, Prokisch H, Heim K, Hartikainen AL, Pouta A, Pekkanen J, Blakemore AIF, Buxton JL, Kaakinen M, Duffy DL, Madden PA, Heath AC, Montgomery GW, Thompson PJ, Matheson MC, Le Souëf P, AAGC collaborators, St Pourcain B, Davey Smith G, Henderson J, Kemp JP, Timpson NJ, Deloukas P, Ring SM, Wichmann HE, Müller-Nurasyid M, Novak N, Klopp N, Rodríguez E, McArdle W, Linneberg A, Menné T, Nohr EA, Hofman A, Uitterlinden AG, van Duijn CM, Rivadeneira F, de Jongste JC, van der Valk RJP, Wjst M, Jogi R, Geller F, Boyd HA, Murray JC, Kim C, Mentch F, March M, Mangino M, Spector TD, Bataille V, Pennell CE, Holt PG, Sly P, Tiesler CMT, Thiering E, Illig T, Imboden M, Nystad W, Simpson A, Hottenga JJ, Postma D, Koppelman GH, Smit HA, Söderhäll C, Chawes B, Kreiner-Møller E, Bisgaard H, Melén E, Boomsma DI, Custovic A et al for the EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet 2012;44(2):187-192 Published online Dec 25 2011. doi: 10.1038/ng.1017.

88. Gore C, Custovic A, Tannock G, Munro K, Kerry G, Johnson K, Peterson C, Morris J, Chaloner C, Murray C, Woodcock A. Treatment and secondary prevention effects of the probiotics Lactobacillus paracasei or Bifidobacterium lactis on early infant-eczema: randomised controlled trial with follow-up to age 3 years. Clin Exp Allergy 2012;42(1):112-22. doi: 10.1111/j.1365-2222.2011.03885.x.

89. Stevens W, Addo-Yobo E, Roper J, Woodcock A, James H, Platts-Mills T, Custovic A. Differences in both prevalence and titer of specific IgE among children with asthma in affluent and poor communities within a large town in Ghana. Clin Exp Allergy 2011; 41(11): 1587-94 doi: 10.1111/j.1365-2222.2011.03832.x.

90. Valovirta E, GAP investigators. Design and recruitment for the GAP trial, investigating the preventive effect on asthma development of an SQ-standardized grass allergy immunotherapy tablet in children with grass pollen-induced allergic rhinoconjunctivitis. Clin Ther. 2011;33(10):1537-46.

91. Custovic A, Soderstrom L, Ahlstedt S, Sly PD, Simpson A, Holt PG. Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood. J Allergy Clin Immunol. 2011;127(6):1480-5.

92. Nicolaou N, Murray C, Belgrave D, Poorafshar M, Simpson A, Custovic A. Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol. 2011;127(3):684-5.

93. Semic-Jusufagic A, Simpson A, Hankinson J, Custovic A. A Polymorphism in Gasdermin B (GSDMB) gene is associated with severe asthma exacerbations in childhood: A population-based birth cohort study. Acta Medica Academica. 2011;40(2):110-121

94. Custovic A, Rothers J, Stern D, Simpson A, Woodcock A, Wright AL, et al. Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like Receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol. 2011;127(2):390-397.e9.

95. Marinho S, Simpson A, Marsden P, Smith JA, Custovic A. Quantification of atopy, lung function and airway hypersensitivity in adults. Clin Transl Allergy. 2011;1(1):16. doi:10.1186/2045-7022-1-16

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96. Murray CS, Canoy D, Buchan I, Woodcock A, Simpson A, Custovic A. Body mass index in young children and allergic disease: Gender differences in a longitudinal study. Clin Exp Allergy. 2011;41(1):78-85.

97. Semic-Jusufagic A, Gevaert P, Bachert C, Murray C, Simpson A, Custovic A. Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children. Pediatr Allergy Immunol. 2010;21(7):1052-8.

98. Quanjer PH et al for the Global Lungs Initiative Collaborators. Changes in the FEV₁/FVC ratio during childhood and adolescence: an intercontinental study. Eur Respir J 2010; 36(6):1391-9

99. Murray CS, Custovic A, Lowe LA, Aldington S, Williams M, Beasley R, Woodcock A. Effect of addition of salmeterol versus doubling the dose of fluticasone propionate on specific airway resistance in children with asthma. Allergy Asthma Proc. 2010;31(5):415-21.

100. Simpson A, Tan VYF, Winn J, Svensén M, Bishop CM, Heckerman DE, Buchan I, Custovic A. Beyond atopy: Multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med. 2010;181(11):1200-6.

101. Kirkby J, Stanojevic S, Welsh L, Lum S, Badier M, Beardsmore C, Custovic A, Nielsen K, Paton J, Tomalak W, Stocks J. Reference equations for specific airway resistance in children: The Asthma UK initiative. Eur Respir J. 2010;36(3):622-9.

102. Al Ali W, Custovic A, Simpson A, Khoury A, Woodcock A. Household characteristics and allergen and endotoxin levels in Aleppo, Syrian Arab Republic. East Mediterr Health J. 2010;16(7):717-24.

103. Semic-Jusufagic A, Simpson A, Murray C, Marinho S, Custovic A. Breastfeeding and the development of asthma and atopy during childhood: a birth cohort study. Acta Medica Academica. 2010; 39: 132-143

104. Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, Härlin A, Woodcock A, Ahlstedt S, Custovic A. Allergy or tolerance in children sensitized to peanut: Prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol. 2010;125(1):191-197.e13.

105. Patel S, Murray CS, Woodcock A, Simpson A, Custovic A. Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy. 2009;64(12):1766-72.

106. Stanojevic S, Wade A, Cole TJ, Lum S, Custovic A, Silverman M, Hall GL, Welsh L, Kirkby J, Nystad W, Badier M, Davis S, Turner S, Piccioni P, Vilozni D, Eigen H, Vlachos-Mayer H, Zheng J, Tomalak W, Jones M, Hankinson JL, Stocks J; Asthma UK Spirometry Collaborative Group. Spirometry centile charts for young Caucasian children: The asthma UK collaborative initiative. Am J Respir Crit Care Med. 2009;180(6):547-52.

107. Fowler SJ, Langley SJ, Truman NJ, Woodcock A, Simpson A, Custovic A. Long term effects of allergen sensitisation and exposure in adult asthma: A prospective study. World Allergy Organ J. 2009 May; 2(5): 83–90

108. Tan VYF, Winn J, Simpson A, Custovic A. Immune system modeling with infer.NET. Proceedings - 4th IEEE international conference on eScience, eScience 2008; p. 364-5.

109. Nicolaou NC, Simpson A, Lowe LA, Murray CS, Woodcock A, Custovic A. Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. J Allergy Clin Immunol. 2008;122(3):500-506.e5.

110. Smith JA, Drake R, Simpson A, Woodcock A, Pickles A, Custovic A. Dimensions of respiratory symptoms in preschool children: Population-based birth cohort study. Am J Respir Crit Care Med. 2008;177(12):1358-63.

111. Bisgaard H, Simpson A, Palmer CNA, Bønnelykke K, Mclean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A. Gene-environment interaction in the onset of eczema in infancy: Filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Medicine. 2008;5(6):0934-40.

112. Gore C, Munro K, Lay C, Bibiloni R, Morris J, Woodcock A, Custovic A. Bifidobacterium pseudocatenulatum is associated with atopic eczema: A nested case-

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control study investigating the fecal microbiota of infants. J Allergy Clin Immunol. 2008;121(1):135-40.

113. Marinho S, Simpson A, Söderström L, Woodcock A, Ahlstedt S, Custovic A. Quantification of atopy and the probability of rhinitis in preschool children: A population-based birth cohort study. Allergy. 2007;62(12):1379-86.

114. Marinho S, Simpson A, Lowe L, Kissen P, Murray C, Custovic A. Rhinoconjunctivitis in 5-year-old children: A population-based birth cohort study. Allergy. 2007;62(4):385-93.

115. Semic-Jusufagic A, Bachert C, Gevaert P, Holtappels G, Lowe L, Woodcock A, Custovic A. Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study. J Allergy Clin Immunol. 2007;119(4):930-6.

116. Murray C, Poletti G, Ahlstedt S, Soderstrom L, Johnston SL, Custovic A. Probability of hospital admission with acute asthma exacerbation increases with increasing specific IgE antibody levels. Allergy Clin Immunol Int: J World Allergy Org 2007; Suppl.2:270-3

117. Addo-Yobo EOD, Woodcock A, Allotey A, Baffoe-Bonnie B, Strachan D, Custovic A. Exercise-induced bronchospasm and atopy in Ghana: Two surveys ten years apart. PLoS Medicine. 2007;4(2):0355-60.

118. Keil T, Kulig M, Simpson A, Custovic A, Wickman M, Kull I, Lødrup Carlsen KC, Carlsen KH, Smit HA, Wijga AH, Schmid S, Von Berg A, Bollrath C, Eller E, Bindslev-Jensen C, Halken S, Høst A, Heinrich J, Fantini MP, Brunekreef B, Krämer U, Willich SN, Wahn U, Lau S; working group of GA2LEN-WP 1.5 Birth Cohorts. European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures - A GA2LEN initiative. Allergy. 2006;61(9):1104-11.

119. Simpson A, John SL, Jury F, Niven R, Woodcock A, Ollier WER, Custovic A. Endotoxin exposure, CD14, and allergic disease: An interaction between genes and the environment. Am J Respir Crit Care Med. 2006;174(4):386-92.

120. Nicolaou NC, Lowe LA, Murray CS, Woodcock A, Simpson A, Custovic A. Exhaled breath condensate pH and childhood asthma: Unselected birth cohort study. Am J Respir Crit Care Med. 2006;174(3):254-9.

121. Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of inhaled fluticasone propionate in wheezy infants (IFWIN): Double-blind, randomised, controlled study. Lancet. 2006;368(9537):754-62.

122. Thomas M, Custovic A, Woodcock A, Morris J, Simpson A, Murray CS. Atopic wheezing and early life antibiotic exposure: A nested case-control study. Pediatr Allergy Immunol. 2006;17(3):184-8.

123. Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL, Custovic A. Study of modifiable risk factors for asthma exacerbations: Virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax. 2006;61(5):376-82.

124. Murray CS, Simpson B, Kerry G, Woodcock A, Custovic A. Dietary intake in sensitized children with recurrent wheeze and healthy controls: A nested case-control study. Allergy. 2006;61(4):438-42.

125. Gore RB, Curbishley L, Truman N, Hadley E, Woodcock A, Langley SJ, Custovic A. Intranasal air sampling in homes: Relationships among reservoir allergen concentrations and asthma severity. J Allergy Clin Immunol. 2006;117(3):649-55.

126. Keil T, Kulig M, Simpson A, Custovic A, Wickman M, Kull I, Lødrup Carlsen KC, Carlsen KH, Smit HA, Wijga AH, Schmid S, Berg A, Bollrath C, Eller E, Bindslev-Jensen C, Halken S, Høst A, Heinrich J, Porta D, Forastiere F, Brunekreef B, Krämer U, Willich SN, Wahn U, Lau S; Working Group of GA(2)LEN-WP 1.5 'Birth Cohorts'. European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs - A GA2LEN initiative. Allergy. 2006;61(2):221-8.

127. Nicolaou N, Yiallouros P, Pipis S, Ioannou P, Simpson A, Custovic A. Domestic allergen and endotoxin exposure and allergic sensitization in Cyprus. Pediatr Allergy Immunol. 2006;17(1):17-21.

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128. Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy. 2006;61(1):119-23.

129. Woodcock AA, Steel N, Moore CB, Howard SJ, Custovic A, Denning DW. Fungal contamination of bedding. Allergy. 2006;61(1):140-2.

130. Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol. 2005;116(4):744-9.

131. Gore C, Johnson RJ, Caress AL, Woodcock A, Custovic A. The information needs and preferred roles in treatment decision-making of parents caring for infants with atopic dermatitis: A qualitative study. Allergy. 2005;60(7):938-43.

132. Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WER, Collins A, Custovic A, Holloway JW, John SL. Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. Am J Respir Crit Care Med. 2005;172(1):55-60.

133. Murray CS, Tannock GW, Simon MA, Harmsen HJM, Welling GW, Custovic A, et al. Fecal microbiota in sensitized wheezy and non-sensitized non-wheezy children: A nested case-control study. Clin Exp Allergy. 2005;35(6):741-5.

134. Hadley EA, Smillie FI, Turner MA, Custovic A, Woodcock A, Arkwright PD. Effect of Mycobacterium vaccae on cytokine responses in children with atopic dermatitis. Clin Exp Immunol. 2005;140(1):101-8.

135. Calam R, Gregg L, Simpson A, Simpson B, Woodcock A, Custovic A. Behavior problems antecede the development of wheeze in childhood: A birth cohort study. Am J Respir Crit Care Med. 2005;171(4):323-7.

136. Lowe LA, Simpson A, Woodcock A, Morris J, Murray CS, Custovic A. Wheeze phenotypes and lung function in preschool children. Am J Respir Crit Care Med. 2005;171(3):231-7.

137. Langley SJ, Goldthorpe S, Craven M, Woodcock A, Custovic A. Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects. Thorax. 2005;60(1):17-21.

138. Al-Mousawi MSH, Lovel H, Behbehani N, Arifhodzic N, Woodcock A, Custovic A. Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency. J Allergy Clin Immunol. 2004;114(6):1389-94.

139. Lowe LA, Woodcock A, Murray CS, Morris J, Simpson A, Custovic A. Lung function at age 3 years: Effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2004;158(10):996-1001.

140. Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P, Simpson A, Custovic A. Early life environmental control: Effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med. 2004;170(4):433-9.

141. Bornehag CG, Sundell J, Bonini S, Custovic A, Malmberg P, Skerfving S, et al. Dampness in buildings as a risk factor for health effects, EUROEXPO: A multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. Indoor Air. 2004;14(4):243-57.

142. Stipić-Marković A, Pevec B, Radulović Pevec M, Čustović A, Predović J. Allergic diseases in relationship with environmental factors in a population of school children in Zagreb, Croatia. Arh Hig Rad Toksikol. 2004;55(2-3):221-8.

143. Lowe L, Murray CS, Martin L, Deas J, Cashin E, Poletti G, Simpson A, Woodcock A, Custovic A. Reported versus confirmed wheeze and lung function in early life. Arch Dis Child. 2004;89(6):540-3.

144. Murray CS, Woodcock A, Smillie FI, Cain G, Kissen P, Custovic A. Tobacco smoke exposure, wheeze, and atopy. Pediatr Pulmonol. 2004;37(6):492-8.

145. Stipić-Marković A, Pevec B, Pevec MR, Čustović A. Prevalence of asthma, allergic rhinitis and conjunctivitis, and atopic eczema symptoms: ISAAC in school population of Zagreb, Croatia. Acta Medica Croatica. 2003;57(4):281-5.

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146. Langley SJ, Goldthorpe S, Custovic A, Woodcock A. Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients. Ann Allergy Asthma Immunol. 2003;91(4):398-404.

147. Gore C, Peterson CGB, Kissen P, Simpson BM, Lowe LA, Woodcock A, Custovic A. Urinary eosinophilic protein X, atopy, and symptoms suggestive of allergic disease at 3 years of age. J Allergy Clin Immunol. 2003;112(4):702-8.

148. Simpson A, Simpson B, Custovic A, Craven M, Woodcock A. Stringent environmental control in pregnancy and early life: The long-term effects on mite, cat and dog allergen. Clin Exp Allergy. 2003;33(9):1183-9.

149. Calam R, Gregg L, Simpson B, Morris J, Woodcock A, Custovic A. Childhood asthma, behavior problems, and family functioning. J Allergy Clin Immunol. 2003;112(3):499-504.

150. Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: Association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol. 2003;112(2):362-8.

151. Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, Britton J, Strachan D, Howarth P, Altmann D, Frost C, Custovic A. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med. 2003;349(3):225-36.

152. Gore RB, Bishop S, Durrell B, Curbishley L, Woodcock A, Custovic A. Air filtration units in homes with cats: Can they reduce personal exposure to cat allergen? Clin Exp Allergy. 2003;33(6):765-9.

153. Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency particulate arrest-filter vacuum cleaners increase personal cat allergen exposure in homes with cats. J Allergy Clin Immunol. 2003;111(4):784-7.

154. Custovic A, Simpson BM, Simpson A, Hallam CL, Marolia H, Walsh D, et al. Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults. J Allergy Clin Immunol. 2003;111(2):402-7.

155. Simpson A, Green R, Custovic A, Woodcock A, Arruda LK, Chapman MD. Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK. Allergy. 2003;58(1):53-6.

156. Francis H, Fletcher G, Anthony C, Pickering C, Oldham L, Hadley E, Custovic A, Niven R. Clinical effects of air filters in homes of asthmatic adults sensitized and exposed to pet allergens. Clin Exp Allergy. 2003;33(1):101-5.

157. Simpson A, Simpson B, Custovic A, Cain G, Craven M, Woodcock A. Household characteristics and mite allergen levels in Manchester, UK. Clin Exp Allergy. 2002;32(10):1413-9.

158. Woodcock A, Moradi M, Smillie FI, Murray CS, Burnie JP, Custovic A. Clostridium difficile, atopy and wheeze during the first year of life. Pediatr Allergy Immunol. 2002;13(5):357-60.

159. Addo-Yobo EOD, Custovic A, Taggart SCO, Asafo-Agyei AP, Woodcock A. Seasonal variability in exercise test responses in Ghana. Pediatr Allergy Immunol. 2002;13(4):303-6.

160. Gore RB, Hadi EA, Craven M, Smillie FI, O'Meara TJ, Tovey ER, Woodcock A, Custovic A. Personal exposure to house dust mite allergen in bed: Nasal air sampling and reservoir allergen levels. Clin Exp Allergy. 2002;32(6):856-9.

161. Lowe L, Murray CS, Custovic A, Simpson BM, Kissen PM, Woodcock A. Specific airway resistance in 3-year-old children: A prospective cohort study. Lancet. 2002;359(9321):1904-8.

162. Murray CS, Pipis SD, McArdle EC, Lowe LA, Custovic A, Woodcock A. Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population. Thorax. 2002;57(5):388-92.

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163. Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: Case-control study. Br Med J. 2002;324(7340):763-6.

164. Brutsche MH, Joos L, Carlen Brutsche IEA, Bissinger R, Tamm M, Custovic A, et al. Array-based diagnostic gene-expression score for atopy and asthma. J Allergy Clin Immunol. 2002;109(2):271-3.

165. Al Mousawi M, Behbehani N, Arifhodzic N, Lovel H, Woodcock A, Custovic A. Environmental allergens in Kuwait. Allergy. 2001;56(12):1237-8.

166. Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S, McElroy P, Custovic A, Woodcock A, Pritchard D, Venn A, Britton J. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study. Lancet. 2001;358(9292):1493-9.

167. Custovic A, Hallam CL, Simpson BM, Craven M, Simpson A, Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol. 2001;108(4):537-9.

168. Addo-Yobo EOD, Custovic A, Taggart SCO, Craven M, Bonnie B, Woodcock A. Risk factors for asthma in urban Ghana. J Allergy Clin Immunol. 2001;108(3):363-8.

169. Woodcock A, Addo-Yobo EOD, Taggart SCO, Craven M, Custovic A. Pet allergen levels in homes in Ghana and the United Kingdom. J Allergy Clin Immunol. 2001;108(3):463-5.

170. Smillie FI, Elderfield AJ, Patel F, Cain G, Tavenier G, Brutsche M, Craven M, Custovic A, Woodcock A. Lymphoproliferative responses in cord blood and at one year: No evidence for the effect of in utero exposure to dust mite allergens. Clin Exp Allergy. 2001;31(8):1194-204.

171. Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: A randomised trial. Lancet. 2001;358(9277):188-93.

172. Brutsche MH, Brutsche IC, Wood P, Mogulkoc N, Custovic A, Egan J, et al. B-cell isotype control in atopy and asthma assessed with cDNA array technology. Am J Physiol Lung Cell Mol Physiol 2001;280(4 24-4):L627-37.

173. Simpson BM, Custovic A, Simpson A, Hallam CL, Walsh D, Marolia H, et al. NAC Manchester asthma and allergy study (NACMAAS): Risk factors for asthma and allergic disorders in adults. Clin Exp Allergy. 2001;31(3):391-9.

174. Brutsche MH, Brutsche IC, Wood P, Brass A, Morrison N, Rattay M, Mogulkoc N, Simler N, Craven M, Custovic A, Egan J, Woodcock A. Apoptosis signals in atopy and asthma measured with cDNA arrays. Clin Exp Immunol. 2001;123(2):181-7.

175. Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, Makki R, Tavernier G, Smillie FI, Custovic A, Woodcock A, Ollier WER, Hajeer AH. The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun. 2000;1(8):509-14.

176. Brutsche MH, Brutsche IC, Munavvar M, Langley SJ, Masterson CM, Daley-Yates PT, Brown R, Custovic A, Woodcock A. Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: A randomised crossover study. Lancet. 2000;356(9229):556-61.

177. Custovic A, Hallam C, Woodcock H, Simpson B, Houghton N, Simpson A, et al. Synthetic pillows contain higher levels of cat and dog allergen than feather pillows. Pediatr Allergy Immunol. 2000;11(2):71-3.

178. Custovic A, Simpson BM, Simpson A, Hallam C, Craven M, Brutsche M, et al. Manchester Asthma and Allergy Study: Low-allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol. 2000;105(2):252-8.

179. Custovic A, Woodcock H, Craven M, Hassall R, Hadley E, Simpson A, et al. Dust mite allergens are carried on not only large particles. Pediatr Allergy Immunol. 1999;10(4):258-60.

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180. Simpson A, Custovic A, Pipis S, Adisesh A, Faragher B, Woodcock A. Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids. Am J Respir Crit Care Med. 1999;160(1):45-9.

181. Custovic A, Simpson B, Simpson A, Hallam C, Craven M, Woodcock A. Relationship between mite, cat, and dog allergens in reservoir dust and ambient air. Allergy. 1999;54(6):612-6.

182. Green R, Simpson A, Custovic A, Faragher B, Chapman M, Woodcock A. The effect-of air filtration on airborne dog allergen. Allergy. 1999;54(5):484-8.

183. Niven RM, Fletcher AM, Pickering AC, Custovic A, Sivour JB, Preece AR, et al. Attempting to control mite allergens with mechanical ventilation and dehumidification in British houses. J Allergy Clin Immunol. 1999;103(5 II):756-62.

184. Green R, Simpson A, Custovic A, Woodcock A. Vacuum cleaners and airborne dog allergen. Allergy. 1999;54(4):403-5.

185. Hallam C, Custovic A, Simpson B, Houghton N, Simpson A, Woodcock A. Mite allergens in feather and synthetic pillows. Allergy. 1999;54(4):407-8.

186. Hodson T, Custovic A, Simpson A, Chapman M, Woodcock A, Green R. Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. J Allergy Clin Immunol. 1999;103(4):581-5.

187. Tunnicliffe WS, Fletcher TJ, Hammond K, Roberts K, Custovic A, Simpson A, et al. Sensitivity and exposure to indoor allergens in adults with differing asthma severity. Eur Respir J. 1999;13(3):654-9.

188. Cain G, Elderfield AJ, Green R, Smillie FI, Chapman MD, Custovic A, et al. The effect of dry heat on mite, cat, and dog allergens. Allergy. 1998;53(12):1213-5.

189. Simpson A, Hassall R, Custovic A, Woodcock A. Variability of house-dust-mite allergen levels within carpets. Allergy. 1998;53(6):602-7.

190. Custovic A, Fletcher A, Pickering CAC, Francis HC, Green R, Smith A, et al. Domestic allergens in public places III: House dust mite, cat, dog and cockroach allergens in British hospitals. Clin Exp Allergy. 1998;28(1):53-9.

191. Custovic A, Simpson A, Pahdi H, Green RM, Chapman MD, Woodcock A. Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes. Thorax. 1998;53(1):33-8.

192. Addo Yobo EOD, Custovic A, Taggart SCO, Asafo-Agyei AP, Woodcock A. Exercise induced bronchospasm in Ghana: Differences in prevalence between urban and rural schoolchildren. Thorax. 1997;52(2):161-5.

193. Custovic A, Green R, Fletcher A, Smith A, Pickering CAC, Chapman MD, et al. Aerodynamic properties of the major dog allergen Can f 1: Distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med. 1997;155(1):94-8.

194. Custovic A, Green R, Smith A, Chapman MD, Woodcock A. New mattresses: How fast do they become a significant source of exposure to house dust mite allergens? Clin Exp Allergy. 1996;26(11):1243-5.

195. Custovic A, Green R, Taggart SCO, Smith A, Pickering CAC, Chapman MD, et al. Domestic allergens in public places II: Dog (Can f 1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings. Clin Exp Allergy. 1996;26(11):1246-52.

196. Fletcher AM, Pickering CAC, Custovic A, Simpson J, Kennaugh J, Woodcock A. Reduction in humidity as a method of controlling mites and mite allergens: The use of mechanical ventilation in British domestic dwellings. Clin Exp Allergy. 1996;26(9):1051-6.

197. Custovic A, Taggart SCO, Francis HC, Chapman MD, Woodcock A. Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol. 1996;98(1):64-72.

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198. Taggart SCO, Custovic A, Francis HC, Faragher EB, Yates CJ, Higgins BG, et al. Asthmatic bronchial hyperresponsiveness varies with ambient levels of summertime air pollution. Eur Respir J. 1996;9(6):1146-54.

199. Taggart SCO, Custovic A, Richards DH, Woodcock A. GR106642X: A new, non-ozone depleting propellant for inhalers. Br Med J. 1995;310(6995):1639-40.

200. Custovic A, Taggart SCO, Stuart A, Robinson A, Woodcock A. Efficacy of a new non-ozone depleting formulation for salbutamol. J Pharmaceut Med. 1995;5(3-4):161-8.

201. Custovic A, Taggart SCO, Kennaugh JH, Woodcock A. Portable dehumidifiers in the control of house dust mites and mite allergens. Clin Exp Allergy. 1995;25(4):312-6.

202. Custovic A, Taggart SCO, Niven RM, Woodcock A. Evaluating exposure to mite allergens. J Allergy Clin Immunol. 1995;96(1):134-5.

203. Custovic A, Taggart SCO, Woodcock A. House dust mite and cat allergen in different indoor environments. Clin Exp Allergy. 1994;24(12):1164-8.

204. Custovic A, Taggart S, Woodcock A, Arifhodzic N, Haas F, Axen K, et al. Assessing exercise-induced bronchospasm. Chest. 1994;105(5):1624-5.

205. Custovic A, Arifhodzic N, Robinson A, Woodcock A. Exercise testing revisited: The response to exercise in normal and atopic children. Chest. 1994;105(4):1127-32.

206. Arifhodzic N, Ducic V, Custovic A. Double blind placebo controlled trial of the therapeutic effects of Ambroxol. Med Arh 1991;46:24-25

207. Arifhodzic N, Custovic A, Popovic Z. Metered dose inhaler vs. metered dose inhaler-spacer system in the bronchodilator treatment of acute exacerbations of childhood asthma. Med Arh 1991;46:26-28

208. Custovic A, Arifhodzic N, Popovic Z. The effects of Ketotifen on exercise-induced bronchospasm in asthmatic children. Med Arh 1991;46:29-32

209. Arifhodzic N, Djurovic N, Drazeta Z, Custovic A. Paediatric Phadiatop in the early diagnosis of atopy. Period Biol 1991;93:425-26

Review Articles in Academic Journals

1. Holguin F, Cardet JC, Chung KF, Diver S, Ferreira DS, Fitzpatrick A, Gaga M, Kellermeyer L, Khurana S, Knight S, McDonald VM, Morgan RL, Ortega VE, Rigau D, Subbarao P, Tonia T, Adcock IM, Bleecker ER, Brightling C, Boulet LP, Cabana M, Castro M, Chanez P, Custovic A, Djukanovic R, Frey U, Frankemolle B, Gibson P, Hamerlijnck D, Jarjour N, Konno S, Shen H, Vitary C, Bush A. Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline. Eur Respir J. 2020 Jan 2;55(1). pii: 1900588. doi: 10.1183/13993003.00588-2019. Print 2020 Jan. PMID: 31558662

2. Bourdin A, Bjermer L, Brightling C, Brusselle G, Chanez P, Chung F, Custovic A, Diamant Z, Diver S, Djukanovic R, Hamerlijnck D, Johnston S, Kanniess F, Papadopoulos N, Papi A, Russell R, Ryan D, Samitas K, Thomy T, Zervas E, Gaga M. ERS/EAACI Statement on severe exacerbations in asthma in adult: facts, priorities and key research questions. Eur Respir J. 2019 Sep 28;54(3). pii: 1900900. doi: 10.1183/13993003.00900-2019. Print 2019 Sep. PMID: 31467120

3. Roche N, Anzueto A, Bosnic Anticevich S, Kaplan A, Miravitlles M, Ryan D, Soriano JB, Usmani O, Papadopoulos NG, Canonica GW; Respiratory Effectiveness Group Collaborators. The importance of real-life research in respiratory medicine: manifesto of the Respiratory Effectiveness Group: Endorsed by the International Primary Care Respiratory Group and the World Allergy Organization. Eur Respir J. 2019 Sep 19;54(3). pii: 1901511. doi: 10.1183/13993003.01511-2019..

4. Bousquet JJ, Schünemann HJ, Togias A, Erhola M, Hellings PW, Zuberbier T, Agache I, Ansotegui IJ, Anto JM, Bachert C, Becker S, Bedolla-Barajas M, Bewick M, Bosnic-Anticevich S, Bosse I, Boulet LP, Bourrez JM, Brusselle G, Chavannes N, Costa E, Cruz

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AA, Czarlewski W, Fokkens WJ, Fonseca JA, Gaga M, Haahtela T, Illario M, Klimek L, Kuna P, Kvedariene V, Le LTT, Larenas-Linnemann D, Laune D, Lourenço OM, Menditto E, Mullol J, Okamoto Y, Papadopoulos N, Pham-Thi N, Picard R, Pinnock H, Roche N, Roller-Wirnsberger RE, Rolland C, Samolinski B, Sheikh A, Toppila-Salmi S, Tsiligianni I, Valiulis A, Valovirta E, Vasankari T, Ventura MT, Walker S, Williams S, Akdis CA, Annesi-Maesano I, Arnavielhe S, Basagana X, Bateman E, Bedbrook A, Bennoor KS, Benveniste S, Bergmann KC, Bialek S, Billo N, Bindslev-Jensen C, Bjermer L, Blain H, Bonini M, Bonniaud P, Bouchard J, Briedis V, Brightling CE, Brozek J, Buhl R, Buonaiuto R, Canonica GW, Cardona V, Carriazo AM, Carr W, Cartier C, Casale T, Cecchi L, Cepeda Sarabia AM, Chkhartishvili E, Chu DK, Cingi C, Colgan E, de Sousa JC, Courbis AL, Custovic A et al; ARIA Study Group; MASK Study Group. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases. Clin Transl Allergy. 2019 Sep 9;9:44. doi: 10.1186/s13601-019-0279-2. eCollection 2019. Review. PMID: 31516692

5. Custovic A, Murray CS, Simpson A. Dust-mite inducing asthma: what advice can be given to patients? Expert Rev Respir Med. 2019 Oct;13(10):929-936. doi: 10.1080/17476348.2019.1651647. Epub 2019 Aug 19. PMID: 31369320

6. Diamant Z, Vijverberg S, Alving K, Bakirtas A, Bjermer L, Custovic A, Dahlen SE, Gaga M, Gerth van Wijk R, Del Giacco S, Hamelmann E, Heaney L, Heffler E, Kalayci Ö, Kostikas K, Lutter R, Olin AC, Sergejeva S, Simpson A, Sterk PJ, Tufvesson E, Agache I, Seys SF. Towards clinically applicable biomarkers for asthma - An EAACI position paper. Allergy. 2019 Oct;74(10):1835-1851. doi: 10.1111/all.13806. PMID: 30953574

7. Sonntag HJ, Filippi S, Pipis S, Custovic A. Blood biomarkers of sensitization and asthma. Front Pediatr. 2019 Jun 19;7:251. doi: 10.3389/fped.2019.00251. PMID: 31275911

8. Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019 Jun 18;7:246. doi: 10.3389/fped.2019.00246. PMID: 31275909

9. Saglani S, Custovic A. Childhood Asthma: Advances Using Machine Learning and Mechanistic Studies. Am J Respir Crit Care Med. 2019 Feb 15;199(4):414-422. doi: 10.1164/rccm.201810-1956CI. PMID: 30571146

10. Papadopoulos NG, Custovic A, Cabana MD, Lee PR, Dell SD, Deschildre A, Hedlin G, Hossny E, Le Souëf P, Matricardi PM, Nieto A, Phipatanakul W, Pitrez PM, Pohunek P, Gavornikova M, Jaumont X, Price DB. Pediatric asthma: an unmet need for more effective, focused treatments. Pediatr Allergy Immunol. 2019 Feb;30(1):7-16 doi: 10.1111/pai.12990. PMID: 30312503

11. Haider S, Custovic A. Breaking down silos in asthma research: The case for an integrated approach. EMJ Innov. 2019;3(1):82-92.

12. Bousquet J et al; The MASK study group. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma. Clin Transl Allergy. 2019 Mar 11;9:16. doi: 10.1186/s13601-019-0252-0.

13. Bousquet J el al; MASK study group. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence. Clin Transl Allergy. 2018 Oct 25;8:45. doi: 10.1186/s13601-018-0227-6.

14. Oksel C, Haider S, Fontanella S, Frainay C, Custovic A. Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice. Front Pediatr. 2018 Sep 20;6:258. doi: 10.3389/fped.2018.00258.

15. Nakamura T, Haider S, Custovic A. Understanding the heterogeneity of atopic dermatitis in childhood. Current Allergy & Clinical Immunology 2018; 31(3):124-130

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16. Schwarze J, Openshaw P, Jha A, Del Giacco SR, Firinu D, Tsilochristou O, Roberts G, Selby A, Akdis C, Agache I, Custovic A, Heffler E, Pinna G, Khaitov M, Nikonova A, Papadopoulos N, Akhlaq A, Nurmatov U, Renz H, Sheikh A, Skevaki C. Influenza burden, prevention and treatment in asthma - a scoping review by the EAACI Influenza in Asthma Task Force. Allergy. Allergy. 2018 Jun;73(6):1151-1181. doi: 10.1111/all.13333.

17. Korošec P, Gibbs BF, PhD MR, Custovic A, Turner PJ. Important and specific role for basophils in acute allergic reactions. Clin Exp Allergy 2018;48(5):502-512. doi: 10.1111/cea.13117. PMID: 29431885

18. Oksel C, Custovic A. Development of allergic sensitization and its relevance to paediatric asthma. Curr Opin Allergy Clin Immunol. 2018;18(2):109-116. doi: 10.1097/ACI.0000000000000430.

19. Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, Azar A, Baroody FM, Bachert C, Canonica GW, Chacko T, Cingi C, Ciprandi G, Corey J, Cox LS, Creticos PS, Custovic A, Damask C, DeConde A, DelGaudio JM, Ebert CS, Eloy JA, Flanagan CE, Fokkens WJ, Franzese C, Gosepath J, Halderman A, Hamilton RG, Hoffman HJ, Hohlfeld JM, Houser SM, Hwang PH, Incorvaia C, Jarvis D, Khalid AN, Kilpeläinen M, Kingdom TT, Krouse H, Larenas-Linnemann D, Laury AM, Lee SE, Levy JM, Luong AU, Marple BF, McCoul ED, McMains KC, Melén E, Mims JW, Moscato G, Mullol J, Nelson HS, Patadia M, Pawankar R, Pfaar O, Platt MP, Reisacher W, Rondón C, Rudmik L, Ryan M, Sastre J, Schlosser RJ, Settipane RA, Sharma HP, Sheikh A, Smith TL, Tantilipikorn P, Tversky JR, Veling MC, Wang Y, Westman M, Wickman M, Zacharek M. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol. 2018 Feb;8(2):108-352. doi: 10.1002/alr.22073. PMID: 29438602

20. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. After asthma: redefining airways diseases. Lancet. 2018; 391: 350–400 Sep 11. pii: S0140-6736(17)30879-6. doi: 10.1016/S0140-6736(17)30879-6. Epub 2017 Sep 11.

21. Bousquet J, Onorato GL, Bachert C, Barbolini M, Bedbrook A, Bjermer L, de Sousa JC, Chavannes NH, Cruz AA, De Manuel Keenoy E, Devillier P, Fonseca J, Hun S, Kostka T, Hellings PW, Illario M, Ivancevich JC, Larenas-Linnemann D, Millot-Keurinck J, Ryan D, Samolinski B, Sheikh A, Yorgancioglu A, Agache I, Arnavielhe S, Bewick M, Annesi-Maesano I, Anto JM, Bergmann KC, Bindslev-Jensen C, Bosnic-Anticevich S, Bouchard J, Caimmi DP, Camargos P, Canonica GW, Cardona V, Carriazo AM, Cingi C, Colgan E, Custovic A, et al. CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report. Clin Transl Allergy. 2017;7:37. doi: 10.1186/s13601-017-0173-8.

22. Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, MCAN Workshop Report: The indoor environment and childhood asthma: Implications for home environmental intervention in asthma prevention and management. J Allergy Clin Immunol. 2017;140(4):933-949. doi: 10.1016/j.jaci.2017.04.024.

23. Hellings PW, Fokkens W, Bachert C, Akdis CA, Bieber T, Agache I, Bernal-Sprekelsen M, Canonica GW, Gevaert P, Joos G, Lund V, Muraro A, Onerci M, Zuberbier T, Pugin B, Seys SF, Bousquet J; ARIA and EPOS working groups. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A

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EUFOREA-ARIA-EPOS-AIRWAYS ICP statement. Allergy. 2017;72(9):1297-1305. doi: 10.1111/all.13162.

24. Sánchez-Borges M, Fernandez-Caldas E, Thomas WR, Chapman MD, Lee BW, Caraballo L, Acevedo N, Chew FT, Ansotegui IJ, Behrooz L, Phipatanakul W, Gerth van Wijk R, Pascal D, Rosario N, Ebisawa M, Geller M, Quirce S, Vrtala S, Valenta R, Ollert M, Canonica GW, Calderón MA, Barnes CS, Custovic A, Benjaponpitak S, Capriles-Hulett A. International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem. World Allergy Organ J. 2017;10(1):14. doi: 10.1186/s40413-017-0145-4

25. Belgrave D, Henderson J, Simpson A, Buchan I, Bishop C, Custovic A. Disaggregating asthma: Big investigation versus big data. J Allergy Clin Immunol. 2017;139(2):400-407. doi: 10.1016/j.jaci.2016.11.003.

26. Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L. Allergy in severe asthma. Allergy. 2017 Feb;72(2):207-220. doi: 10.1111/all.13072

27. Bousquet J, Bewick M, Cano A, Eklund P, Fico G, Goswami N et al. Building bridges for innovation in ageing: Synergies between Action Groups of the EIP on AHA. J Nutr Health Aging. 2017;21(1):92-104. doi: 10.1007/s12603-016-0803-1.

28. Bousquet J, Hellings PW, Agache I, Bedbrook A, Bachert C, Bergmann KC et al. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy. 2016;6:47. doi: 10.1186/s13601-016-0137-4..

29. Calderon MA, Demoly P, Casale T, Akdis CA, Bachert C, Bewick M, Bilò BM, Bohle B, Bonini S, Bush A, Caimmi DP, Canonica GW, Cardona V, Chiriac AM, Cox L, Custovic A, De Blay F, Devillier P, Didier A, Di Lorenzo G, Du Toit G, Durham SR, Eng P, Fiocchi A, Fox AT, van Wijk RG, Gomez RM, Haathela T, Halken S, Hellings PW, Jacobsen L, Just J, Tanno LK, Kleine-Tebbe J, Klimek L, Knol EF, Kuna P, Larenas-Linnemann DE, Linneberg A, Matricardi M, Malling HJ, Moesges R, Mullol J, Muraro A, Papadopoulos N, Passalacqua G, Pastorello E, Pfaar O, Price D, Del Rio PR, Ruëff R, Samolinski B, Scadding GK, Senti G, Shamji MH, Sheikh A, Sisul JC, Sole D, Sturm GJ, Tabar A, Van Ree R, Ventura MT, Vidal C, Varga EM, Worm M, Zuberbier T, Bousquet J. Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project. Clin Transl Allergy. 2016 Nov 23;6:41 doi: 10.1186/s13601-016-0131-x

30. Deliu M, Belgrave D, Sperrin M, Buchan I, Custovic A. Asthma phenotypes in childhood. Expert Rev Clin Immunol. 2016 Nov 18:1-9. [Epub ahead of print] PMID: 27817211

31. Deliu M, Sperrin M, Belgrave D, Custovic A. Identification of asthma subtypes using clustering methodologies. Pulm Ther. 2016;2:19-41. Epub 2016 Jun 22; PMID: 27512723

32. Bousquet J, Farrell J, Crooks G, Hellings P, Bel EH, Bewick M, Chavannes NH, de Sousa JC, Cruz AA, Haahtela T, Joos G, Khaltaev N, Malva J, Muraro A, Nogues M, Palkonen S, Pedersen S, Robalo-Cordeiro C, Samolinski B, Strandberg T, Valiulis A, Yorgancioglu A, Zuberbier T, Bedbrook A, Aberer W, Adachi M, Agusti A, Akdis CA, Akdis M, Ankri J, Alonso A, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Bai C, Baiardini I, Bachert C, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Kheder AB, Bennoor KS, Benson M, Bergmann KC, Bieber T, Bindslev-Jensen C,

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Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosnic-Anticevitch S, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Caimmi D, Calderon MA, Calverley PM, Camargos PA, Canonica GW, Camuzat T, Carlsen KH, Carr W, Carriazo A, Casale T, Cepeda Sarabia AM, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, Cirule I, Cox L, Costa DJ, Custovic A et al. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin Transl Allergy. 2016 Jul 29;6:29. doi: 10.1186/s13601-016-0116-9

33. Roberts G, Ollert M, Aalberse R, Austin M, Custovic A, DunnGalvin A, Eigenmann PA, Fassio F, Grattan C, Hellings P, Hourihane J, Knol E, Muraro A, Papadopoulos N, Santos AF, Schnadt S, Tzeli K.A new framework for the interpretation of IgE sensitization tests. Allergy. 2016 May 25. doi: 10.1111/all.12939. [Epub ahead of print]

34. Bousquet J et al, MASK study group. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol. 2016;138(2):367-374.e2. doi: 10.1016/j.jaci.2016.03.025

35. Castro-Rodriguez JA, Custovic A, Ducharme FM. Treatment of asthma in young children: evidence-based recommendations. Asthma Res Pract. 2016;2:5. PMID: 27965773 DOI: 10.1186/s40733-016-0020-z

36. Belgrave DC, Simpson A, Buchan IE, Custovic A. Atopic dermatitis and respiratory allergy: What is the link? Curr Dermatol Rep. 2015;4(4):221-227. Epub 2015 Sep 28.

37. Howard R, Rattray M, Prosperi M, Custovic A. Distinguishing asthma phenotypes using machine learning approaches. Curr Allergy Asthma Rep. 2015;15(7):542. doi: 10.1007/s11882-015-0542-0.PMID: 26143394

38. Custovic A. To what extent is allergen exposure a risk factor for the development of allergic disease? Clin Exp Allergy. 2015;45(1):54-62. doi: 10.1111/cea.12450.

39. Custovic A, Johnston SL, Pavord I, Gaga M, Fabbri L, Bel EH, Le Souëf P, Lötvall J, Demoly P, Akdis CA, Ryan D, Mäkelä MJ, Martinez F, Holloway JW, Saglani S, O'Byrne P, Papi A, Sergejeva S, Magnan A, Del Giacco S, Kalayci O, Hamelmann E, Papadopoulos NG. EAACI position statement on asthma exacerbations and severe asthma. Allergy 2013;68:1520–1531. DOI: 10.1111/all.12275

40. Belgrave DC, Custovic A, Simpson A. Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management. Expert Rev Clin Immunol. 2013;9(10):921-936

41. Roberts G, Xatzipsalti M, Borrego LM, Custovic A, Halken S, Hellings PW, Papadopoulos NG, Rotiroti G, Scadding G, Timmermans F, Valovirta E. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102-16. doi: 10.1111/all.12235

42. Custovic A, Lazic N, Simpson A. Pediatric asthma and development of atopy. Curr Opin Allergy Clin Immunol. 2013;13(2):173-80

43. Bousquet J, Anto J, Sunyer J, Nieuwenhuijsen M, Vrijheid M, Keil T; MeDALL Study Group; CHICOS Study Group; ENRIECO Study Group; GA²LEN Study Group. Pooling birth cohorts in allergy and asthma: European Union-funded initiatives - a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper. Int Arch Allergy Immunol. 2013;161(1):1-10. doi: 10.1159/000343018.

44. Custovic A, Simpson A. The role of inhalant allergens in allergic airways disease. J Investig Allergol Clin Immunol. 2012;22(6):393-401

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45. Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R et al. International consensus on (ICON) pediatric asthma. Allergy. 2012;67(8):976-97

46. Custovic A, Marinho S, Simpson A. Gene-environment interactions in the development of asthma and atopy. Expert Rev Respir Med. 2012;6(3):301-8.

47. Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA(2)LEN - ARIA Position Paper. Int Arch Allergy Immunol 2012;158(3):216-231.

48. Custovic A, Simpson A. Gene–environment interactions in asthma: Lessons for the development of new drugs for asthma. Inhalation 2011;5(6):18-23

49. Nicolaou N, Custovic A. Molecular diagnosis of peanut and legume allergy. Curr Opin Allergy Clin Immunol. 2011;11(3):222-8.

50. Custovic A, Simpson A, Bardin PG, Le Souëf P. Allergy is an important factor in asthma exacerbation: A pro/con debate. Respirology. 2010;15(7):1021-7.

51. Bousquet J, Schünemann HJ, Zuberbier T, Bachert C, Baena-Cagnani CE, Bousquet PJ...Custovic A et al. Development and implementation of guidelines in allergic rhinitis - an ARIA-GA2LEN paper. Allergy. 2010;65(10):1212-21.

52. Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, van Wijk RG, Ohta K, Zuberbier T, Schünemann HJ; Global Allergy and Asthma European Network; Grading of Recommendations Assessment, Development and Evaluation Working Group. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010 Sep;126(3):466-76.

53. Bousquet J, Bachert C, Canonica GW, Casale TB, Cruz AA, Lockey RJ, Zuberbier T; Extended Global Allergy and Asthma European Network, World Allergy Organization and Allergic Rhinitis and its Impact on Asthma Study Group. Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol. 2009 Sep;124(3):428-33.

54. Simpson A, Custovic A. Prevention of allergic sensitization by environmental control. Curr Allergy Asthma Rep. 2009;9(5):363-9.

55. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens W, Togias A, Zuberbier T, Baena-Cagnani C, Canonica GW, van Weel C, Agache I, Ait-Khaled N, Bachert C, Blaiss M, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Custovic A, Chen Y, Dahl R, Demoly P, Douagui H, Durham S, van Wijk RG, Kalayci O, Kaliner M, Kim YY, Kowalski ML, Kuna P, Lemiere C, Lan LTT, Li J, Lockey R, Mavale S, Meltzer EO, Mohammad Y, Mullol J, Naclerio R, O’Hehir R, Ohta K, Ouedraogo S, Palkonen S, Papadopoulos N, Passalacqua G, Pawankar R, Popov T, Rabe K, Rosado-Pinto J, Scadding G, Simons FER, Toskala E, Valovirta E, van Cauwenberge P, Wang DY, Wickman M, Yawn B, Yorgancioglu A, Yusuf O, Zar H. Allergic rhinitis and its impact on asthma (ARIA) 2008 update. Allergologie. 2009;32(8):306-19.

56. Chapman MD, Ferreira F, Villalba M, Cromwell O, Bryan D, Becker WM, Fernández-Rivas M, Durham S, Vieths S, van Ree R; CREATE consortium. The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines. J Allergy Clin Immunol. 2008 Nov;122(5):882-889.e2.

57. Brand PL, Baraldi E, Bisgaard H, Boner AL, Castro-Rodriguez JA, Custovic A, de Blic J, de Jongste JC, Eber E, Everard ML, Frey U, Gappa M, Garcia-Marcos L, Grigg J, Lenney W, Le Souëf P, McKenzie S, Merkus PJ, Midulla F, Paton JY, Piacentini G, Pohunek P, Rossi GA, Seddon P, Silverman M, Sly PD, Stick S, Valiulis A, van Aalderen WM, Wildhaber JH, Wennergren G, Wilson N, Zivkovic Z, Bush A.Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach. Eur Respir J. 2008;32(4):1096-110.

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58. Sly PD, Boner AL, Björksten B, Bush A, Custovic A, Eigenmann PA, Gern JE, Gerritsen J, Hamelmann E, Helms PJ, Lemanske RF, Martinez F, Pedersen S, Renz H, Sampson H, von Mutius E, Wahn U, Holt PG. Early identification of atopy in the prediction of persistent asthma in children. Lancet. 2008;372(9643):1100-6.

59. Bousquet J, Fokkens W, Burney P, Durham SR, Bachert C, Akdis CA, Canonica GW, Dahlen SE, Zuberbier T, Bieber T, Bonini S, Bousquet PJ, Brozek JL, Cardell LO, Crameri R, Custovic A, Demoly P, van Wijk RG, Gjomarkaj M, Holland C, Howarth P, Humbert M, Johnston SL, Kauffmann F, Kowalski ML, Lambrecht B, Lehmann S, Leynaert B, Lodrup-Carlsen K, Mullol J, Niggemann B, Nizankowska-Mogilnicka E, Papadopoulos N, Passalacqua G, Schünemann HJ, Simon HU, Todo-Bom A, Toskala E, Valenta R, Wickman M, Zock JP. Important research questions in allergy and related diseases: Non-allergic rhinitis: A GA2LEN paper. Allergy. 2008;63(7):842-53.

60. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Agache I, Aït-Khaled N, Bachert C, Blaiss MS, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Chen Y, Custovic A et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA2LEN and AllerGen). Allergy. 2008;63(Suppl. 86):8-160.

61. van Ree R, Chapman MD, Ferreira F, Vieths S, Bryan D, Cromwell O, Villalba M, Durham SR, Becker WM, Aalbers M, André C, Barber D, Cistero Bahima A, Custovic A, et al. The CREATE project: Development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy. 2008;63(3):310-26.

62. Simpson A, Custovic A. Genetic and environmental influences on childhood asthma. Current Allergy and Clinical Immunology. 2007;20(1):4-7

63. Semic-Jusufagic A, Custovic A. Active smoking among asthmatic youth - how concerned we need to be. Int J Chron Obstruct Pulmon Dis. 2007;2(1):3-4.

64. Bousquet J, van Cauwenberge P, Aït Khaled N, Bachert C, Baena-Cagnani CE, Bouchard J, Bunnag C, Canonica GW, Carlsen KH, Chen YZ, Cruz AA, Custovic A et al. Pharmacologic and anti-IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN). Allergy. 2006;61(9):1086-96.

65. Marinho S, Simpson A, Custovic A. Allergen avoidance in the secondary and tertiary prevention of allergic diseases: Does it work? Prim Care Respir J. 2006;15(3):152-8.

66. Custovic A, Simons FER. Drugs used in paediatric allergy: Should we conduct studies in children or extrapolate from adults? Clin Exp Allergy Rev. 2006;6(1):1-5.

67. Custovic A, Van Wijk RG. The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma: ARIA update (in collaboration with GA2LEN). Allergy. 2005;60(9):1112-5.

68. Custovic A, Murray C, Simpson A. Allergy and infection: Understanding their relationship. Allergy. 2005;60(Suppl. 79):10-13

69. Simpson A, Custovic A. The role of allergen avoidance in the secondary prevention of atopic disorders. Curr Opin Allergy Clin Immunol. 2005;5(3):223-7.

70. Simpson A, Custovic A. Pets and the development of allergic sensitization. Curr Allergy Asthma Rep. 2005;5(3):212-20.

71. Sehgal N, Custovic A, Woodcock A. Potential roles in rhinitis for protease and other enzymatic activities of allergens. Curr Allergy Asthma Rep. 2005;5(3):221-6.

72. Murray CS, Simpson A, Custovic A. Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc. 2004;1(2):99-104.

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73. Asher I, Baena-Cagnani C, Boner A, Canonica GW, Chuchalin A, Custovic A, et al. World Allergy Organization guidelines for prevention of allergy and allergic asthma: Condensed version. Int Arch Allergy Immunol. 2004;135(1):83-92.

74. Asher I, Baena-Cagnani C, Boner A, Canonica GW, Chuchalin A, Custovic A, et al. World Allergy Organization guidelines for prevention of allergy and allergic asthma. Allergy Clin Immunol International. 2004;16(5):176-85.

75. Simpson A, Custovic A. Exposure to domestic pets: effect on sensitisation and asthma. Airways J 2004; 2: 39-42

76. Gore C, Custovic A. Protective parasites and medicinal microbes? The case for the hygiene hypothesis. Prim Care Respir J. 2004;13(2):68-75.

77. Lowe L, Custovic A, Woodcock A. Childhood asthma. Curr Allergy Asthma Rep. 2004;4(2):159-65.

78. Simpson A, Custovic A. Allergen avoidance in the primary prevention of asthma. Curr Opin Allergy Clin Immunol. 2004;4(1):45-51.

79. Gore C, Custovic A. Primary and secondary prevention of allergic airway disease. Paediatr Respir Rev. 2003;4(3):213-24.

80. Lowe L, Custovic A, Woodcock A. Childhood asthma. Curr Allergy Asthma Reports. 2003;3(2):109-14.

81. Simpson A, Custovic A. Early pet exposure: Friend or foe? Curr Opin Allergy Clin Immunol. 2003;3(1):7-14.

82. Custovic A, Simpson BM, Murray CS, Lowe L, Woodcock A. The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol. 2002;13(Suppl 15):32-7.

83. Gore C, Custovic A. Preventive measures and their effects. Results from cohort studies. Paediatr Respir Rev. 2002;3(3):205-18.

84. Custovic A, Murray CS. The effect of allergen exposure in early childhood on the development of atopy. Curr Allergy Asthma Rep. 2002;2(5):417-23.

85. Custovic A, Murray CS, Gore RB, Woodcock A. Controlling indoor allergens. Ann Allergy Asthma Immunol. 2002;88(5):432-42.

86. Gore RB, Custovic A. Aeroallergen avoidance: What practical advice can we give to patients? CPD Bulletin Immunol Allergy. 2002;2(2):40-3.

87. Murray CS, Custovic A. Tips on avoiding indoor allergens. Asthma J. 2002;7(1):40-1.

88. Custovic A, Woodcock A. Environmental allergen exposure and asthma: Prospects for primary prevention. Mediators Inflamm. 2001;10(6):295-8.

89. Murray CS, Woodcock A, Custovic A. The role of indoor allergen exposure in the development of sensitization and asthma. Curr Opin Allergy Clin Immunol. 2001;1(5):407-12.

90. Liccardi G, Custovic A, Cazzola M, Russo M, D'Amato M, D'Amato G. Avoidance of allergens and air pollutants in respiratory allergy. Allergy. 2001;56(8):705-22.

91. Custovic A, Woodcock A. Exposure and sensitization in infants and children. Curr Opin Allergy Clin Immunol. 2001;1(2):133-8.

92. Woodcock A, Custovic A. Allergen avoidance. Schweiz Med Wochenschr. 2000;130(49):1903-8.

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93. Høst A, Boner A, Odhiambo J, Custovic A. Preventive measures. Allergy Clinical Immunol International. 2000;12(6):296-9.

94. Woodcock A, Custovic A. Allergen avoidance: Does it work? Br Med Bull. 2000;56(4):1071-86.

95. Asher I, Boner A, Chuchalin A, Custovic A, Dagli E, Haus M, et al. Prevention of allergy and asthma interim report based on the WHO/IAACI meeting on the primary prevention of allergy and asthma. Allergy. 2000;55(11):1069-88.

96. Custovic A, Woodcock A. Clinical effects of allergen avoidance. Clin Rev Allergy Immunol. 2000;18(3):397-419.

97. Custovic A, Woodcock A. Indoor environment and asthma. Monaldi Arch Chest Dis. 1999;54(6):465-9.

98. Custovic A, Woodcock A. Reducing allergens exposure in asthma patients. Practitioner. 1999;243(1596):232-5.

99. Custovic A, Woodcock A. Environmental manipulation: Practical steps in the home to benefit asthma patients. Asthma J. 1999;4(1):24-7.

100. Custovic A, Woodcock A. Indoor environmental factors and respiratory illness. Clin Exp Allergy. 1998;28(10):1178-81.

101. Custovic A, Chapman M. Risk levels for mite allergens. Are they meaningful? Allergy. 1998;53(Suppl 48):71-6.

102. Custovic A, Simpson A, Woodcock A. Importance of indoor allergens in the induction of allergy and elicitation of allergic disease. Allergy 1998;53(Suppl.48):115-20

103. Woodcock A, Custovic A. The role of indoor environment in determining the severity of asthma. Thorax 1998;53(Suppl.2):S47-S51

104. Custovic A, Simpson A, Chapman MD, Woodcock A. Allergen avoidance in the treatment of asthma and atopic disorders. Thorax. 1998;53(1):63-72.

105. Woodcock A, Custovic A. ABC of allergies: Avoiding exposure to indoor allergens. Br Med J. 1998;316(7137):1075-8.

106. Custovic A, Smith A, Woodcock A. Indoor allergens are a primary cause of asthma. Eur Respir Rev. 1998;8(53):155-8.

107. Woodcock A, Custovic A, Smith A. Metered dose inhalers: The need for change. Eur Respir Rev. 1998;8(53):179-80.

108. Custovic A, Woodcock A. Allergen avoidance. Br J Hosp Med. 1996;56(8):409-12.

Editorials/Rostrum Articles in Academic Journals

1. Custovic A, Henderson J, Simpson A. Does understanding endotypes translate to better asthma management options for all? J Allergy Clin Immunol. 2019 Jul;144(1):25-33. doi: 10.1016/j.jaci.2019.05.016. Epub 2019 May 27., PMID: 31145940

2. Roche N, Anzueto A, Bosnic Anticevich S, Kaplan A, Miravitlles M, Ryan D, Soriano JB, Usmani O, Papadopoulos NG, Canonica GW; Respiratory Effectiveness Group Collaborators. The importance of real-life research in respiratory medicine: manifesto of the Respiratory Effectiveness Group: Endorsed by the International Primary Care Respiratory Group and the World Allergy Organization. Eur Respir J. 2019 Sep 19;54(3). pii: 1901511. doi: 10.1183/13993003.01511-2019. Print 2019 Sep.

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3. Polack FP, Stein RT, Custovic A. The syndrome we agreed to call bronchiolitis. J Infect Dis. 2019 Jun 19;220(2):184-186. doi: 10.1093/infdis/jiz082. PMID: 30783666

4. Lenney W, Adachi Y, Bush A, Fischer GB, Hong J, Ostrem A, Pedersen S, Sly PD, Szefler SJ, Tilak R, Zar HJ; GSK Global Children's Asthma Group. Asthma: moving toward a global children's charter. Lancet Respir Med. 2019 Apr;7(4):299-300. doi: 10.1016/S2213-2600(19)30074-8.

5. Bousquet J et al, Mobile Airways Sentinel Network (MASK) Study Group. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology. J Allergy Clin Immunol. 2019 Mar;143(3):864-879. doi: 10.1016/j.jaci.2018.08.049. PMID: 30273709

6. Bush A, Custovic A. Formula one: best is no formula. Eur Respir J. 2017; 49: 1700105 [https://doi.org/10.1183/13993003.00105-2017].

7. Belgrave D, Custovic A. The importance of being earnest in epidemiology. Acta Paediatrica 2016;105(12):1384-6

8. Bousquet J et al. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation. Allergy. 2015;70(11):1372-92. doi: 10.1111/all.12686. Epub 2015 Sep 13.

9. Bousquet J, Addis A, Adcock I, Agache I, Agusti A, Alonso A, Annesi-Maesano I, Anto JM, Bachert C, Baena-Cagnani CE, Bai C, Baigenzhin A, Barbara C, Barnes PJ, Bateman ED, Beck L, Bedbrook A, Bel EH, Benezet O, Bennoor KS, Benson M, Bernabeu-Wittel M, Bewick M, Bindslev-Jensen C, Blain H, Blasi F, Bonini M, Bonini S, Boulet LP, Bourdin A, Bourret R, Bousquet PJ, Brightling CE, Briggs A, Brozek J, Buhl R, Bush A, Caimmi D, Calderon M, Calverley P, Camargos PA, Camuzat T, Canonica GW, Carlsen KH, Casale TB, Cazzola M, Cepeda Sarabia AM, Cesario A, Chen YZ, Chkhartishvili E, Chavannes NH, Chiron R, Chuchalin A, Chung KF, Cox L, Crooks G, Crooks MG, Cruz AA, Custovic A, et al. Integrated care pathways for airway diseases (AIRWAYS-ICPs). Eur Respir J. 2014;44(2):304-23. doi: 10.1183/09031936.00014614

10. Belgrave D, Simpson A, Custovic A. Challenges in interpreting wheeze phenotypes: the clinical implications of statistical learning techniques. Am J Respir Crit Care Med. 2014;189(2):121-3. doi: 10.1164/rccm.201312-2206ED.

11. Papadopoulos NG, Agache I, Bavbek S, Bilo BM, Braido F, Cardona V, Custovic A et al. Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clin Transl Allergy. 2012;2(1):21.

12. Bousquet J, Schünemann HJ, Samolinski B… Custovic A et al in collaboration with the World Health Organization Collaborating Center for Asthma and Rhinitis. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs. J Allergy Clin Immunol. 2012;130(5):1049-62

13.Ring J, Akdis C, Behrendt H, Lauener R, Schäppi G, Akdis M, Ammann W, De Beaumont O, Bieber T, Bienenstock J, Blaser K, Bochner B, Bousquet J, Crameri R, Custovic A et al. Davos declaration: allergy as a global problem. Allergy 2012;67:141–143

14. Custovic A, Nicolaou N. Peanut allergy: Overestimated in epidemiology or underdiagnosed in primary care? J Allergy Clin Immunol. 2011;127(3):631-2.

15. Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF, Wardlaw AJ, Wenzel SE, Greenberger PA. Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127(2):355-60.

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16. Custovic A, Bush RK. Two blind mice: New insights into mouse allergy. J Allergy Clin Immunol. 2007;120(4):758-9.

17. Semic-Jusufagic A, Simpson A, Custovic A. Environmental exposures, genetic predisposition and allergic diseases: One size never fits all. Allergy. 2006;61(4):397.

18. Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: Increasing prevalence with increasing urbanization. Allergy. 2005;60(11):1357-60.

19. Custovic A, Simpson A. Environmental allergen exposure, sensitisation and asthma: From whole populations to individuals at risk. Thorax. 2004;59(10):825-7.

20. Gore C, Custovic A. Can we prevent allergy? Allergy. 2004;59(2):151-61. 21. Gore RB, Custovic A. Is allergen avoidance effective? Clin Exp Allergy. 2002;32(5):662-

6. 22. Simpson A, Woodcock A, Custovic A. Housing characteristics and mite allergen levels:

To humidity and beyond. Clin Exp Allergy. 2001;31(6):803-5. 23. Custovic A, Woodcock A. On allergens and asthma (again): Does exposure to allergens

in homes exacerbate asthma? Clin Exp Allergy. 2001;31(5):670-3. 24. Custovic A, Woodcock A. Feather or synthetic? That is the question. Clin Exp Allergy.

1999;29(2):144-7.

AUTHORED BOOKS

1. Managing Allergy. Edited by Adnan Custovic and Thomas Platts-Mills. Atlas Medical Publishing, 1st edition 2009; ISBN-13: 978 1 84692 025 7, ISBN-ebook 978 1 84692 593 1 ISBN-10: 1846920256 282 pages

BOOK CHAPTERS

1. Custovic A. Epidemiology of allergic diseases. In: Middleton's Allergy Essentials, First Edition, Eds. O’Hehir RE, Holgate ST, Sheikh A; Elsevies Inc, 2017: 51-72

2. Custovic A, Tovey ER. Allergen control for prevention and management of allergic diseases. In: Middleton's Allergy: Principles and Practice, 8th Edition, Eds. Adkinson NF Jr, Bochner BS, Burks W, Busse WW, Holgate ST, Lemanske RF Jr, O’Hehir RE; Elsevies Inc, 2014: 1406-1415

3. Sideri K, Custovic A. Endocrine-co morbid and coexisting; gender, menstrual cycle, hypo-and hyper-thyroidism, Addison's disease, vitamin D, testosterone deficiency. In: Asthma, Comorbidities, Coexisting Conditions and Differential Diagnosis; Eds. Lockey RF, Ledford D; Oxford University Press, 2014; 334-344

4. Custovic A. Birth cohorts. In: Global atlas of allergy; Eds. Akdis CA, Agache I, European Academy of Allergy and Clinical Immunology, 2014; 119-120

5. Custovic A. The complex network of asthma risk and protective factors. In: Global atlas of asthma; Eds. Akdis CA, Agache I, European Academy of Allergy and Clinical Immunology, 2013; 55-56

6. Lødrup Carlsen KC, Custovic A. Lung development from birth through adolescence and the role of asthma and allergy. In: Paediatric Asthma; Eds: Carlsen K-H, Gerritsen J.; European Respiratory Society Monographs 2012; 56 (Paediatric Asthma): 82-96; DOI: 10.1183/1025448x.10000212

7. Castro-Rodriguez JA, Rodriguez-Martinez CE, Custovic A. Infantile and Pre-school Asthma. In: Paediatric Asthma; Eds: Carlsen K-H, Gerritsen J.; European Respiratory Society Monographs 2012; 56 (Paediatric Asthma): 10-21; DOI: 10.1183/1025448x.10000212

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8. Gruchalla RS, Custovic A, von Mutius E. Epidemiology of Allergy and Asthma. In: Allergy, 4th Edition. Eds: Holgate ST, Church MK, Broide DH, Martinez FD. Elsevier Limited, Oxford, 2012: 63-73

9. Haahtela T, Von Hertzen L, Custovic A. Prevention of allergic diseases. In: Pawankar R, Canonica GW, Holgate ST, and Lockey RF, editors. WAO White Book on Allergy (World Allergy Organization), 2011: 133-138

10. Custovic A, van Wijk RG. Allergen avoidance. In: Pawankar R, Canonica GW, Holgate ST, and Lockey RF, editors. WAO White Book on Allergy (World Allergy Organization), 2011: 127-132

11. Woodcock A, Custovic A. Allergen avoidance. In: Asthma and COPD, 2nd edition. Eds Barnes PJ, Drazen JM, Rennard SI, Thomson NC. Academic Press Ltd, London, 2009: 589-598

12. Simpson A, Woodfolk J, Custovic A, Platts Mills-TAE. What the future holds. In: Managing Allergy. Eds Custovic A, Platts-Mills TAE. Atlas Medical Publishing, 2009: 257-266

13. Custovic A. Allergen avoidance. In: Managing Allergy. Eds. Custovic A, Platts-Mills TAE. Atlas Medical Publishing, 2009: 225-242

14. Custovic A. Allergen control in the prevention and management of allergic disease. In: Middleton's Allergy: Principles and Practice, 7th Edition, Eds. Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Simons FER, Holgate ST Eds, Elsevies Inc, 2009: 1447-1458

15. Custovic A, Simpson A. Animal Allergens. In Allergy and Allergic Diseases, Ed. AB Kay, Wiley-Blackwell Scientific, London 2008: 997-1016

16. Marinho S, Custovic A. Management of the asthmatic patient. In: Clinical Immunology, Third Edition. Eds. Rich R, Fleisher TA, Shearer WT, Schroeder HW, Frew AJ, Weyand CM., Elsevier Ltd, London 2008: 607-626

17. Crane J, von Mutius E, Custovic A. Epidemiology of Allergic Disease. In: Allergy, 3rd

Edition. Eds: Holgate ST, Church MK, Lichenstein ML. Elsevier Limited, Oxford, 2006, (BMA Medical Book of the Year 2007)

18. Custovic A, Lødrup Carlsen KC, Carlsen KH. Allergy and the paediatric lung during development. In: Respiratory Diseases in Infants and Children. Eds: Frey U, Gerritsen J. European Respiratory Monograph 2006; Vol. 37: 79-92

19. Custovic A, Simpson A. Dust mite. In: Encyclopaedia of Respiratory Medicine. Eds: Laurent GL and Shapiro S. Elsevier Limited, Oxford, UK 2006: 54-59

20. Host A, Boner A, Odhiambo J, Custovic A, Lockey R. Preventative Measures: early intervention. In: Prevention of allergy and allergic asthma. World Allergy Organization Project Report and Guidelines. Eds: Johansson SGO, Haahtela T. Karger, Basel 2004: 135-151

21. Custovic A, Wahn U, Woodcock A. Prevention of asthma. In: European Respiratory Monograph 23: Asthma. Eds: Chung F, Fabbri LM. European Respiratory Society Journals Ltd, Sheffield and Maney Publishing, London, 2003: 429-448

22. Custovic A, Woodcock A. Prevention of asthma. In: Respiratory Medicine, third edition. Eds: Gibson J, Geddes D, Costabel U, Sterk P, Corrin B. Harcourt Health Sciences, London 2003: 1295-1305

23. Murray CS, Woodcock A, Custovic A. Life style and indoor air pollution: Allergens. In: European Respiratory Monograph 21: The Impact of air pollution on respiratory health.

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Eds: D’Amato G, Holgate ST. European Respiratory Society Journals Ltd, Sheffield and Maney Publishing, London, 2002:133-152

24. Custovic A, Woodcock A. Allergen avoidance. In: Asthma and COPD: Basic Mechanisms and Clinical Management. Eds: Barnes PJ, Rodger IW, Thomson NC. Academic Press Ltd, London 2002: 489-508

25. Custovic A, Woodcock A. The significance of allergen avoidance: Effective clinical manoeuvres to limit or prevent disease. In: The effective management of asthma. Eds: Partridge MR, Miles A. Aesculapius Medical Press, London, San Francisco, Sidney, 2002: 19-43

26. Custovic A, Woodcock A. Avoiding environmental triggers. In: Practical Paediatric Respiratory Medicine. Eds: Silverman M, O’Callaghan CL. Arnold Publishers Limited, London, New York, New Delhi, 2001: 275-284

27. Woodcock A, Custovic A. Allergen avoidance: does it work? In: Allergic disease: a view to the future. Ed: A B Kay. British Medical Bulletin 2000; 56 (4): 1071-1086

28. Custovic A, Simpson A, Woodcock A. Benefits of allergen avoidance. In: Atlas of asthma. Eds: Djukanovic R, Holgate ST. Partenon Publishing Group, New York-London, 1999: 76-78

29. Woodcock A, Custovic A. Avoiding exposure to indoor allergens. In: ABC of allergies. Ed: Durham SR. BMJ Books, London, 1998: 32-35

30. Custovic A, Woodcock A. Allergen avoidance. In: Asthma: Basic Mechanisms and Clinical Management 3rd Edition. Eds: Barnes PJ, Rodger IW, Thomson NC. Academic Press Ltd, London, 1998: 617-649

31. Custovic A, Chapman MD. Indoor allergens as a risk factor for asthma. In: Asthma. Eds: Barnes PJ, Grunstein MM, Leff A, Woolcock AJ. Lippincott-Raven Publishers, Philadelphia-New York, 1997: 82-103

ACADEMIC JOURNAL LETTERS1. Bulfone-Paus S, Bahri R, Shamji MH, Custovic A, Turner PJ. Reply to Mast cell

activation test versus basophil activation test and related competing issues. J Allergy Clin Immunol. 2018 Jul 25. pii: S0091-6749(18)30931-X. doi: 10.1016/j.jaci.2018.06.021. PMID: 30055830

2. Custovic A, Simpson A, Bardin PG, Le Souëf P. Allergy and asthma exacerbation: Adding to the Pro/Con debate – Response. Respirology 2011; 16(2): 378-379.

3. Van Der Wouden JC, Bernsen RMD, Custovic A, Simpson A. Pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2005;159(4):401.

4. Woodcock A, Custovic A. Bed covers and dust mites. N Engl J Med 2003; 349: 1760

CONFERENCE CONTRIBUTIONS, REFEREED 1. Haider S, Custovic A. Big data and multiomics for asthma cure: The case for. Pediatric

Pulmonology. 2018;53:S11–S12. https://doi.org/10.1002/ppul.24030

2. Oksel C, Custovic A. Allergy for the respiratory pediatrician: which tests and interventions are useful? Pediatric Pulmonology. 2018;53:S56–S57. https://doi.org/10.1002/ppul.24031

3. Custovic A. Diagnostic tests in paediatric allergy. Pediatr Pulmonol 2014; 49 (Suppl 37): S8-S9

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https://doi.org/10.1002/ppul.24031

https://doi.org/10.1002/ppul.24030

4. Custovic A. Gene-environment interactions in the development of asthma. International Journal on Immunorehabilitation 2011; 13(1): 10-11

5. Custovic A. Is asthma an allergic disease? International Journal on Immunorehabilitation 2011; 13(1): 15-16

6. Custovic A, Simpson A. What are we learning from genetic cohort studies? Paediatr Respir Rev. 2006;7(Suppl. 1):S90-2.

7. Custovic A. Primary prevention by avoidance and elimination. Drugs Today (Barc). 2008 Dec;44 Suppl B:11-5.

8. Lack G, Custovic A, Beyer K, Eigenmann P. Lessons regarding the IgE system. Allerg Immunol (Paris) 2005; 37(2) :72-4

9. Custovic A, Platts-Mills T. "Kill the cat", or buy one? Advanced Studies in Medicine. 2004;4(7 A):S525-6.

10. Simpson A, Custovic A. The role of allergen avoidance in primary and secondary prevention. Pediatr Pulmonol. 2004;37(Suppl. 26):225-8.

11. Custovic A, Simpson A, Woodcock A. Manchester cohort. Pediatr Pulmonol. 2004;37(Suppl. 26):12-3.

12. Custovic A, Woodcock A. Environmental allergen exposure and asthma: prospects for primary prevention. Mediat Inflamm 2001; 10: 295-298

13. Custovic A, Woodcock A. Exposure to indoor allergens and asthma severity. Proceedings of 2nd Convegno Internazionale DAM. DAM Milan, 1999: 85-88

14. Fletcher AM, Custovic A, Pickering CAC, Francis H, Green R, Woodcock A. Levels of mite, cat and dog allergen in the furnishing of hospital wards. In: Maroni M, Ed. Ventilation and indoor air quality in hospitals. Kluwer Academic Publishers, Dodrecht, 1996: 263-269

15. Custovic A, Taggart S, Chapman M, Fletcher A, Woodcock A. Steam cleaning and Der p 1 concentration in carpets. In: Tovey E, Fifoot A, Sieber L, Eds. Mites, Asthma and Domestic Design II. University Printing Service, Sydney 1995: 45-47

16. Custovic A, Taggart S, Fletcher A, Chapman M, Pickering CA, Woodcock A. House dust mite allergens in public buildings and public transport. In: Tovey E, Fifoot A, Sieber L, Eds. Mites, Asthma and Domestic Design II. University Printing Service, Sydney 1995: 89-91

17. Fletcher A, Custovic A, Kennaugh J, Taggart S, Pickering CA, Woodcock A. Dehumidification as a method of mite allergen avoidance in United Kingdom: Can it work? In: Tovey E, Fifoot A, Sieber L, Eds. Mites, Asthma and Domestic Design II. University Printing Service, Sydney 1995: 101-103

18. Fletcher AM, Custovic A, Pickering CAC, Francis H, Green R, Woodcock A. Levels of mite, cat and dog allergen in the furnishing of hospital wards. In: Maroni M, Ed. Proceedings of Healthy buildings '95. University of Milano and International Centre for Pesticide Safety, Milano 1995: 1011-1015

NON-PEER REVIEWEDProfessional Journal Papers1. Murray CS, Custovic A. Tips on avoiding indoor allergens. J Asthma 2002; 7: 40-41

2. Custovic A. Pet allergens rife in public transport vehicles. J Asthma 2000; 5: 90

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3. Custovic A, Woodcock A. Indoor environment and allergic disease: Importance of allergens. The Practitioner 1999; 243: 232-235

4. Custovic A. Safety of antihistamines. Targeted Therapeutic News. No35, April 1998

5. Custovic A, Woodcock A. Methods of environmental allergen control. Respiratory Disease in Practice 1998; 15 (3):18-21

6. Custovic A, Woodcock A. Air filtration units in the treatment of cat allergy. Asthma Journal 1998; 3: 174

7. Custovic A, Woodcock A. Damp housing and asthma. Asthma Journal 1997; 2 (2):73

8. Custovic A, Woodcock A. Cat and dog allergy explained. Asthma Journal 1996; 1 (2): 14-17

9. Custovic A, Woodcock A. Exposure to indoor allergens and asthma. Asthma Care Today 1995; 3: 54-55

Popular Journal Papers1. Custovic A, Woodcock A. How to reduce allergens in the home. Exchange. Quarterly

Journal of the National Eczema Society 1998; 90: 14-15

2. Custovic A, Woodcock A. Threats from pets. Low allergen living: The National Asthma Campaign Low Allergen House Magazine. The National Asthma Campaign, London, 1994: 21-22

Review of Academic Books1. Custovic A, Woodcock A. Book review: House dust mites-How they affect asthma,

eczema and other allergies by Des Whitrow. Clin Exp Allergy 1995; 25: 1264

Published Abstracts>400 published abstracts from national and international meetings, available on request.

2. DETAILS OF GRANTS AWARDED

MRC Programme Grant MR/S025340/1: Principal investigator UNICORN (Unified Cohorts Research Network): Disaggregating asthma; 01/03/20-01/03/24 £ 2,384,471.03

MRC Biomedical Catalyst: DPFS MR/S019685/1: Co-Investigator (PI P Turner) Improved diagnostics in food allergy (ID-in-FA) Study01/09/2019-31/08/2022 £1,031,452.41

MRC Grant MR/S002359/1: Principal Investigator Lung function trajectories from birth to school age in African children, and their early life determinants01/09/2018-31/08/2021 £ 910,566

The JP Moulton Charitable Foundation; Co InvestigatorTemperature controlled laminar airflow (TLA) in the treatment of moderate to severe atopic eczema in children and adolescents – a randomised placebo controlled phase 2 study.01/07/2019-30/06/2022 £ 391,222

Charles Wolfson Charitable Trust; Supporting Imperial’s Paediatric Clinical

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Research Facility at St Mary’s Hospital01/07/18-30/06/20 £ 500,000

The JP Moulton Charitable Foundation; Co InvestigatorThe SO-CMA Study: Improving the Safety of Oral immunotherapy for Cow's Milk Allergy01/03/2018-28/02/2020 £295,407

Wellcome Trust Strategic Award 108818/15/Z; Co-applicant & Workstream leadPulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?01/09/2016-31/08/2021 £4,640,000Directly allocated £ 458,923

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, AUK-BC-2015-01; Co-applicant and theme leadAugust 2016-August 2021 £1,999,074

NIHR Imperial Biomedical Research Centre; Real-time differential tracking of white blood cells during food-induced allergic reactions in human subjects; Principal InvestigatorAugust 2016-August 2017 £ 60,000

MRC Fellowship for Danielle Belgrave, MR/M015181/1; Main supervisorUnified probabilistic latent variable modelling strategies to accelerate endotypediscovery in longitudinal studies01/10/2015-30/09/2019 £260,596

MRC Industry CASE Studentship MR/M016242/1; Co-supervisor Objective markers of IgE-mediated adverse reactions to food: A proteomics approach01/10/2015-30/09/2019 £100,000

The JP Moulton Charitable Foundation; Principal InvestigatorThe role of uric acid metabolism in pathogenesis of anaphylaxis: The effect of allopurinol on experimentally-induced allergic reaction to peanut in peanut allergic subjects 01/04/2016-01/10/2017 £ 300,000

MRC Health eResearch Centre (HeRC) doctoral training scheme; Co-supervisor Dimensions of respiratory symptoms during childhood (Dr Matea Deliu)September 2015-September 2018 £60,000

MRC Grant MR/L012693/1: Co-applicant MRC/BBSRC Flagship Consortium in Systems Immunology of the Human Life Course: Phenotyping immune responses in asthma and respiratory infections - a systems approach to understanding changes from childhood to adulthood 31/05/2014-30/05/2019 £2,200,000

MRC Health eResearch Centre (HeRC) doctoral training scheme; Co-supervisor Distinguishing asthma and allergy endotypes using longitudinal probabilistic modelling Rebecca HowardSeptember 2014-September 2017 £60,000

North West Lung Research Centre Charity; Principal InvestigatorMechanisms of anaphylaxis: Genetic and functional studies of allergy to bees, wasps & nuts01/07/2014-30/06/2016 £ 76,781

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North West Lung Research Centre Charity; Principal Investigator Investigating functional impact of variants in DNAH7 in a protozoan Tetrahymena Thermophila 20/07/2014-17/07/2015 £ 21,141

Asthma UK Centre for Applied Research: Co-applicant 01/10/2013-30/09/2017 £2,000,000

MRC Research Grant MR/K002449/1: Principal applicantMICA: STELAR (Study Team for Early Life Asthma Research) consortium – Asthma e-lab and identification of novel endotypes of childhood asthma 25/01/2013 - 24/07/2017 £1,498,110

MRC E-Health Informatics Research Centres (MR/K006665/1): Health e-Research Centre (HeRC); Co-applicant and programme lead (Scalable Endotypes in Asthma, Allergies and Andrology) 01/03/2013 - 28/02/2018 £4,719,860

European Union Seventh Framework Programme; Co-applicantIntegrated Approaches to Food Allergen and Allergy Risk Management (iFAM)01/03/13-01/03/17 Euro 9,000,000Direct to the University of Manchester £1,352,010

NIRH South Manchester Respiratory and Allergy Clinical Research Facility (RACRF) Co-applicant 01/09/2012-31/08/2017 £2,500,000

The JP Moulton Charitable Foundation; Co-applicantAvoiding mite allergen to prevent asthma exacerbations in children01/05/2011-30/04/2014 £343,237

The JP Moulton Charitable Foundation; Principal applicantSusceptibility to infection and exacerbations of asthma: markers and mechanisms01/04/2011-31/03/2013 £ 318,005

British Lung Foundation; Co-applicant Epigenetic factors in the development of asthma in childhood 01/01/2010-31/12/2010 £ 54,000

NIHR Capital Investment Funding, 2009, Co-applicant £2,450,000

NIHR Translational Research Facility in Respiratory Medicine; Co-applicantJune 2008-May2012 £2,000,000

MRC Research grant G0601361: Co-applicant Genetic and environmental influences on childhood asthma: the STELAR collaboration 01/02/2008 - 30/07/2010 £ 794,678

The Grand Charity: Principal applicantGenetic studies in the Manchester Asthma and Allergy StudyJan 2008-Dec 2008 £ 100,000

The Moulton Charitable Trust; Principal applicantGene-environment interactions in the development of asthma and allergiesNov 2007-Nov 2009 £ 275,000

GlaxoSmithKline; Principal applicant: Early inhaled steroids in wheezy infantsNov 2007-Oct 2010 £ 156,877

NHS-HEFCE New Blood Senior Clinical Lectureships

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Sponsor for Dr Clare MurrayAug 2007-Jul 2012 £ 225,000

Fundação para a Ciência e a Tecnologia, Portugal-POCI 2010Funding for Dr Susana MarinhoOct 2005-Oct 2008 £ 60,000

Asthma UK Grant No 05/005; Co-applicantAsthma UK Growth Charts for Lung Function in Young Children01/10/05-30/09/08 £ 203,559

European Respiratory Society Long-term Research Fellowship (Dr N Nicolaou)01/05/2004-30/04/2005 £ 20,000

Asthma UK Grant No 04/014; Principal applicantThe NAC Manchester Asthma and Allergy Study-Risk factors for the development of asthma and primary prevention by Environmental control01/10/04-30/09/07 £ 190,966

The Moulton Charitable Trust; Principal applicantGene-environment interactions in the development of asthma and allergies01/05/04-30/04/06 £ 232,273

European Union the Fifth Framework Programme; Co-applicantDevelopment of certified reference materials for allergenic products and validation of methods for their quantification (CREATE): Sub-contractorOctober 2002-September 2005; Award for the service elements £ 11,000

The Wellcome Trust Grant No 066 247; Principal applicantAsthma and Atopy in Urban and Rural Ghanaian Children01/09/2002-28/02/2004 £ 132,247

National Asthma Campaign Grant No 01/012; Principal applicantThe National Asthma Campaign Manchester Asthma and Allergy Study-Primary prevention of asthma by allergen avoidance in high risk infants01/10/01-30/09/04 £ 150,000

Merck-Sharp-Dohme Academic Grants; Co-applicant Urinary LTE4 in asthmatic subjects in relation to atopic status and exposure to allergens June 2001-June 2002 £ 20,596

GlaxoWellcome Respiratory Clinical Research Award; Principal applicantRisk Factors for Atopic Wheeze in Early Life: A Case-Control StudyJune 2001-June 2002 £ 62,590

The National Asthma Campaign Senior Research FellowshipJanuary 2000-January 2005 £ 355,237

Foundation Lancardis: Principal applicant Exposure to domestic allergens and development of sensitisation and atopic disease in high risk infants"; January 2000-January 2003 £ 75,000

Kuwaiti Foundation for the Advancement of Science; Principal applicantRisk factors for asthma in KuwaitApril 1999-April 2002 £ 52,000

National Asthma Campaign Grant No 362; Principal applicantPrimary prevention of asthma by allergen avoidance in high risk infantsSeptember 1998-September 2001 £ 190,740

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NHS National R&D Programme on Asthma Management; Co-applicantAM1/02/015: The effect of mite allergen avoidance by the use of allergenimpermeable bedding on asthma control in adults; 1998-2001 £ 728,678

NHS Executive North West Grant RDO/18/66; Principal applicantBronchial hyperreactivity in infancySeptember 1997-September 1999 £ 60,000

Glaxo Wellcome: Early inhaled steroids in wheezy infants; Co-applicant May 1997-May 2002 £ 525,000

National Asthma Campaign Grant No 301; Principal applicantPrimary prevention of asthma by allergen avoidance in high risk infantsSeptember 1995-September 1998 £ 217,000

Foundation Lancardis; Principal applicantPet allergens and asthma March 1995-March 1998 £ 75,000

Total 1995-2018 >£40,000,000

3. OTHER RESEARCH ACHIEVEMENT S

Academic invitations for presentations at major international or national meetings (Invitations on an “all-expense paid” basis)1. World Allergy Congress 2019, Lyon 12-14/12/2019

Plenary session “Pathways leading to atopic diseases and atopic multimorbidity”: Atopic phenotypes and their implication in the atopic march

2. The 11th Excellence in Pediatrics Conference, Copenhagen, 5-7/12/2019 Masterclass: Anaphylaxis Respiratory advances and updates: Does understanding asthma heterogeneity translate to better management options

3. British Thoracic Society Winter Meeting, 04/12/2019, London Symposium “COPD: it’s not just tobacco”: Lung function trajectories, environmental and drug associated causes of COPD

4. 2nd Moscow Molecular Allergy Meeting, 19/11/2019, Moscow, Russia Plenary lecture: Component-resolved diagnostics microarrays and sensitization algorithms for prediction of asthma.

5. Pediatric Allergy and Asthma Meeting (PAAM 2019), 17-19/10/2019, Florence, Italy Postgraduate Course: Clinical phenotypes of asthma Postgraduate Course : Diagnostic difficulties and treatment options for wheezing infants Symposium: Treatment of preschool wheezePRO/CON Session: Children with allergic asthma should be treated with biologicals

6. BSACI 2019 Meeting, Harrogate, 3-5/10/2019Session “Current challenges in asthma”: Challenging dogma in the practice of asthma

7. Argentine Association of Allergy and Immunology 42nd Annual Congress, 15-17/08 2019 Plenary lecture: The role of allergic sensitization in childhood asthma Plenary lecture: Findings from cohort studies on atopic respiratory diseases

8. EAACI XXVIII Annual Congress, Lisbon 01-05 June 2019 Symposium: Emerging concepts in hygiene hypothesis Symposium: Paediatric asthma: From phenotype discovery to clinical practice

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9. KAAACI-KAPARD-WPAS-INTERASMA Joint Congress, Seoul, S Korea, 9-11 May 2019 Plenary Lecture: The diverse trajectories of allergy across the life course Symposium: Disaggregating asthma: Big investigation vs. big data

10. 4th Annual inhalation and respiratory drug delivery congress, London, 29-30 April 2019 Plenary Lecture: Asthma: Where Are We Now, And Where Do We Want To Go?

11. Respiratory Effectiveness Group Summit 2019, Athens, 28-10 March 2019 Pro-con debate: The term pre-school wheezing should be abandoned

12. 60th Congress of the German Society of Pneumology, Munich, 15-16 March 2019 Symposium: Redefining chronic obstructive airways diseases

13. Here be Lungs 8 Conference, Stellenbosch, South Africa, 6-9 March 2019 Plenary lectures: 1. Uncontrolled pediatric asthma – Additional treatment challenges; 2. Allergen avoidance; 3. Asthma – where are we now , and where do we want to go?

14. The 10th Excellence in Pediatrics Conference, Prague, 6-8 December 2018 Masterclass: Allergy management Respiratory advances and updates: The myth of the allergic march

15. 14th Congress of the Chilean Society of Paediatric Pulmonology, Santiago, 25-27/10/18 Plenary Lectures: (1) Using phenotypes to inform asthma treatment; (2) Aeroallergen Avoidance; (3) Diagnostic tests in paediatric allergy; (4) Immunotherapy - Does it work and who should get it?

16. Joint congress of South African Paediatric Association and South African Allergy Society, Cape Town, 30 August-2 September 2018 Plenary lecture: Preschool wheezing: What is new?

17. 7th Wong Hock Book Paediatric Masterclass 2018, National University Hospital Singapore, 17-19 August 2018 Plenary lecture: The future of diagnostic testing; Plenary lecture: How to allergy-proof the child: Facts and fiction; Pro-Con debate: Allergic march: Fact or fiction?

18. CIPP XVII-17th International Congress on Pediatric Pulmonology, Toledo, 21-24/06 2018 Plenary lecture: Big data and multiomics will find the cure of asthma Symposium: (1) Allergy for the respiratory paediatrician: Which tests and interventions are useful?; (2) STELAR birth cohorts

19. 9th IPCRG World Conference, Porto, Portugal, 31 May-2 June 2018 Symposium: Who develops allergies and why?

20. EAACI XXVII Annual Congress, Munich 25-29 May 2018 Symposium: Atopic march: Does it happen? Symposium: Are severe asthma exacerbations related to a specific phenotype?

21. 13th Pediatric Allergy and Asthma Congress, Fethiye, Turkey, 20-23 April 2018 Plenary lecture: Rural-urban differences in asthma and allergy: What can we learn from studies around the world? Plenary lecture: Environmental exposures, genetic predisposition and trajectories of asthma & allergies through life-course

22. Pan African Thoracic Society and South African Thoracic Society Congress, Durban, 12th to 15th April 2018 Paediatric track: Asthma phenotypes in paediatrics: does this really matter?

23. 12th annual Panhellenic Congress of the Hellenic Society of Allergology and Clinical Immunology, Athens, March 29-April 1 2018 Plenary lecture: Using phenotypes to inform management in pediatric asthma: what is currently possible?

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24. American Academy of Allergy, Asthma & Immunology and the World Allergy Organization Joint Congress, Orlando, USA, 2-5 March 2018 Discussion Leader: Engaging underserved populations in clinical/translational research Symposium: Allergen exposure, sensitization and asthma: what should we learn from the opposing results

25. British Thoracic Society (BTS) Winter Meeting 2017, London 6-8 December 2017 Symposium: What can we do about allergens in the home? Early life exposures, immunotherapy and allergen avoidance

26. 5th Pediatric Allergy and Asthma Meeting (PAAM), London, 26-28 October 2017 Symposium: The Asthmas - as I understand them

27. Connecting Asthma Care Australasian Conference, Adelaide, 16-17 October 2017Symposium: Role of Rhinitis in Asthma Management

28. 8th Annual Meeting of Greek Paediatric Allergy Society, Athens 6-8 October 2017 Plenary lecture: Asthma: Where are we now and where we want to be?

29. CIPP XVI-16th International Congress on Pediatric Pulmonology, Lisbon, 22-25/06/2017 Plenary lecture: Food allergy for respiratory paediatrician Symposium: (1) Allergic rhinitis; (2) Immunotherapy in the treatment of asthma and allergic disorders

30. EAACI XXVI Annual Congress, Helsinki 17-21 June 2017 Symposium: Primary and secondary prevention of house dust mite allergy

31. Sixth Congress of the Portuguese Society of Paediatric Allergy, Faro, 12-13 May 2017 Plenary lecture: Severe asthma in children

32. 12e Congrès Francophone d'Allergologie, Paris, 25-28 April 2017 Plenary lecture: Environmental exposures, genetic predisposition and trajectories of asthma & allergies through lifecourse

33. Here be lungs 6 Conference, Stellenbosch, South Africa, 16 & 17 March 2017 Plenary lectures: (1) Barriers to effective implementation of asthma guidelines; (2) Atopic march: Does it exist; (3) Asthma phenotypes in childhood and adolescence: From endotype discovery to stratified treatments; (4) Diagnostic tests in paediatric allergy; (5) Rural-urban differences in asthma and allergy: What can we learn from studies around the world?

34. British Thoracic Society (BTS) Winter Meeting 2016, London 7-9 December 2016 Joint BTS/BPRS symposium: The study team for early life asthma research (STELAR) consortium

35. 30th Congress of the Spanish Society of Allergy and Clinical Immunology, San Sebastian, 19-21 October 2016 Plenary lecture: Environmental allergen exposure and the development of asthma Pro-Con session: Asthma Prediction Index is useful in infantile wheezing: Con

36. 6ʰ Slovenian Pneumology Congress joined with Golnik Symposium and Balkan Pneumology Meeting, 6-8/10/2016 Plenary lecture: Asthma phenotyping: a key for precision medicine Plenary lecture: Atopic march

37. VIII International Immunology congress and II Pediatric Allergy, Asthma and Immunology Congress, Lima, Peru, 27-30/09/2016 Plenary lectures: (1) Diagnostic tests in paediatric allergy; (2) Gene-Environment Interactions in the development of asthma and allergies; (3) Asthma phenotypes in

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childhood and adolescence: From endotype discovery to stratified treatments; (4) Severe asthma in childhood; (5) Environmental control in the management of asthma

38. British Paediatric Respiratory Society 18th Annual symposium, Nottingham, 07-08/07/16 Plenary lecture: Personalised medicine in paediatric asthma and allergy Debate: This house believes the allergic march does not happen: For

39. Ninth World Asthma, Allergy and COPD Forum, Saint Petersburg, 01-04/07/2016 Plenary lecture: Allergen avoidance in asthma – Does it work and is it workable?

40. CIPP XV-15th International Congress on Pediatric Pulmonology, Naples, 23-26/06/2016 Plenary lecture: The rural-urban differences in asthma and allergy: What can we learn from studies around the world? Symposium: How can we share experience and borrow strengths?

41. EAACI XXV Annual Congress, Vienna, 11-15 June 2016 Symposium: Development of asthma: The role of genes and the environment Symposium: Does genetics have anything to do with asthma exacerbations?

42. The 55th Annual Swineford Allergy Conference, Charlottesville, 01-02/04/2016 Plenary lecture: Understanding the relationship between sensitisation and allergic disease

43. 12th International course on paediatric pulmonology, Saint-Jean Cap-Ferrat, 18-20/03/16 Plenary lecture: The role of allergy biomarkers in the diagnosis and management of severe asthma Plenary lecture: Environmental control in the management of asthma: What works, what does not

44. XXIII World Congress of Asthma, Madrid, 12-15/03/2016 Symposium: Asthma phenotypes in childhood and adolescence

45. Danish Society of Pediatric Asthma and Pulmonology Annual Meeting, 22-23/01/2016 Plenary lecture: Asthma in childhood and adolescence

46. 3rd Middle East-Asia allergy asthma immunology congress, Abu Dhabi, 10-13/12/15 Workshop: How to manage viral- induced exacerbations and co-morbidities Symposium: Asthma exacerbations: From genetics to biomarkers Symposium: Indoor allergens and endotoxins at home

47. The annual UK dermatology course for consultants, Manchester 27-28 November 2015 Plenary lecture: Peanut and food allergy

48. 4th Congress of respiratory medicine – Serbia, Novi Sad, 15-19 October 2015 Plenary lecture: Asthma in childhood and adolescence: From endotype discovery to adaptive personalisation

49. 1st Congress of the Croatian society for mucosal immunology, Opatija, 1-4 October 2015 Plenary lecture: Asthma endotypes and stratified treatments

50. European Respiratory Society Annual Congress, Amsterdam, 26-30 September 2015 Symposium: Childhood wheezing

51. CIPP XIV-14th International Congress on Pediatric Pulmonology, Krakow, 25-28 June ‘15 Symposium: Is atopic march a myth? Pro-Con session: Does asthma exist in infancy? (Con)

52. EAACI XXIV Annual Congress, Barcelona, 6-10 June 2015 Postgraduate course: How can lifestyle, diet and environment affect asthma/allergy? Symposium; Allergic sensitization: a prerequisite for asthma in childhood? Symposium; Sensitisation phenotypes and future risk

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53. Second congress of the Croatian society for allergy and clinical immunology, Zagreb, 22-23 May 2015 Plenary lecture: Is hygiene hypothesis the only explanation?

54. Konsul Bergh Scientific Symposium 2015, Stockholm, 7th May 2015 Plenary lecture: Can biomarkers improve prevention of asthma and allergic disease?

55. Eight World Asthma, Allergy and COPD Forum, Singapore, 26-29 April 2015 Plenary lecture: Gene-environment interactions in the development of asthma Plenary lecture: Asthma in childhood and adolescence: From endotype discovery to adaptive personalisation

56. 11th International Course on Paediatric Pulmonology, Costa Rica, 10-12 April 2015 Plenary lecture: Paediatric asthma and the development of allergy Plenary lecture: Severe asthma and asthma exacerbations

57. International Severe Asthma Forum, Athens, 13-15 November 2014 Plenary lecture: The role of allergy biomarkers in the diagnosis and management of severe adult asthma

58. Ninth Annual Nemacolin International Asthma Conference, Farmington, Pennsylvania, October 31 – November 2, 2014 Keynote lecture: Asthma in Childhood and adolescence: From endotype to adaptive personalization Pro-Con: Environmental allergens are important in the origins of childhood asthma

59. BSACI Annual Meeting, Telford 28-30 September 2014 Main symposium: Allergen avoidance: Does it work and is it workable

60. CIPP XIII-13th International Congress on Pediatric Pulmonology, Bruges, 26-29 June Plenary lecture: Pediatric Allergy - Year in review Symposium: Diagnostic tests in pediatric allergy Symposium: Childhood wheezing: The resolved, the controlled and the troublesome

61. Bronchitis IX; Lungs on the edge of health and aging, Groningen, 23-25 June Plenary lecture: Is allergen avoidance important? What advice should we give to asthma patients?

62. EAACI XXIII Annual Congress, Copenhagen, 7-11 June 2014 Symposium; Pet exposure and allergy: Can we make a better diagnosis of pet allergy Symposium; Emerging themes in primary care: Primary prevention of allergy JMA Educational Session: Effective communication skills: impacting presentations

63. American Thoracic Society International Conference 2014, May 16-21, San Diego Scientific Symposium; Asthma birth cohorts: what have we learned? The next frontier: Gene-environment interactions

64. The Annual meeting of the Association of Icelandic Allergy and Immunologists & The Association of Icelandic pulmonary specialists, 11th April 2014, Reykjavik Plenary lecture: Gene-environment interactions in the development of asthma and atopy Plenary lecture: Prevention of asthma and allergies

65. Asia Pacific Congress of Allergy, Asthma, and Clinical Immunology (APCAACI 2013), November 14-17, Taipei, Taiwan Main symposium: Severe asthma in children Main symposium: Diagnostic tests in paediatric allergy

66. Indian Academy of Allergy 9th Biennial conference, Goa, 26-29 September 2013 Plenary lecture: Asthma phenotypes in childhood and their management Plenary lecture: Indoor allergens and airway disease

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67. 67th National Congress of the Mexican College of Clinical Immunology and Allergy, 7-10 August 2013, Acapulco Plenary lecture: New era in severe asthma treatment

68. BSACI Annual Meeting, Telford 8-10 July 2013 Main symposium: When enough is enough: allergen exposure thresholds and allergic disease

69. New Zealand 2013 Respiratory Workshop, Rotorua 4-6 July 2013 Keynote speaker: Is asthma an allergic disease? Keynote speaker: Environmental control in the management of asthma Symposium: Diagnostic tests in paediatric allergy (30 minutes)

70. EAACI XXII Annual Congress, Milan, 22-26 June 2013 Postgraduate course: Component resolved diagnostics for food allergy Symposium: Genes or environment: what matters? Symposium: Asthma in childhood and adolescence: from phenotype to endotype Symposium: Environmental predictors of asthma exacerbations

71. CIPP XII-12th International Congress on Pediatric Pulmonology, Valencia 29/06-01/07/13 Plenary lecture: Prevention of Asthma and Allergies – Science or Fiction?

72. British Thoracic Society (BTS) Summer Meeting, Manchester, 13-14 June 2013 Symposium: What do we need to know about allergy?

73. Ithemba Le Afrika Congress 2013 (Combined congress of Allergy Society of South Africa, South African Thoracic Society and African Society for Immune Deficiency), Sun City, 5-9 June 2013 Plenary lecture: Is controller therapy for asthma really worthwhile? Symposium: Respiratory allergy in childhood (infant wheezing, allergic asthma, diagnosis, treatment and prognosis)

74. American Academy of Allergy, Asthma and Immunology Annual Meeting, San Antonio, 22-26 February 2013 Symposium: New approaches to identifying asthma phenotypes in childhood

75. Swiss Allergy and Clinical Immunology Conference, Grindelwald, 18-20 January 2013 Plenary lecture: Infection, allergy and asthma Masterclass: Management of asthma in childhood

76. The 2nd International Allergy, Asthma and Immunology Conference, Jerusalem, November 28-30 2012 Plenary lecture: Molecular diagnosis of food allergy Symposium: Asthma endotypes

77. XIX Turkish National Allergy and Clinical Immunology Congress, Antalya, 7-11 November 2012 Plenary lecture: Beyond aggregated definitions of heterogeneous diseases in genetic studies Symposium: Diagnostic tests in paediatric allergy

78. Ninth South American Society of Paediatric Pneumology Congress, Vina del Mar, Chile, 17-21 October 2012 Plenary lecture: Asthma endotypes and asthma phenotypes in children Plenary lecture: Gene-environment interactions in the development of asthma Symposium: Management of allergic rhinitis Symposium: Does allergy play a role in asthma?

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79. International Severe Asthma Forum, Gothenburg, 11-13 October 2012 Plenary lecture: Clusters of allergic diseases in children Pro-con session: Is stepwise approach to asthma management coming to an end?

80. Seventh Hong Kong Allergy Convention, 15-16 September 2012 Plenary symposium: Primary prevention of allergies: Science or fiction Plenary symposium: Environmental control in the management of asthma Symposium: Asthma endotypes: A new approach to the classification and treatment

81. EAACI XXI Annual Congress, Geneva, 10-21 June 2012 Symposium: Asthma phenotypes and gene-environment interactions Pro-con session: Allergen avoidance is successful in primary and secondary prevention of allergy

82. 6th World Conference of the International Primary Care Respiratory Group (IPCRG), Edinburgh 25-28 April 2012 Plenary lecture: Primary and secondary prevention of asthma

83. Fifth World Asthma and COPD Forum, New York, 22-25 April 2012 Plenary lecture: Asthma: Nature or nurture? Plenary lecture: How many diseases are there in asthma?

84. Temple Street Children’s Hospital Respiratory Meeting, Dublin, 10th February 2012 Plenary lecture: Diagnostic tests in paediatric allergy

85. World Allergy Organisation XII World Allergy Congress, Cancun, 4-8 December 2011 Debate: Environmental Control for Allergic Diseases: Does it Work? EAACI Symposium: Infection and asthma endotypes Meet the expert: Topical treatment of atopic dermatitis

86. 7e Congrès Francophone Pédiatrique de Pneumologie et d’Allergologie, Paris 17-19 November 2011 Plenary lecture: Asthma: Nature or nurture?

87. Paediatric Allergy and Asthma Meeting (PAAM 2011), Barcelona 13-15 October 2011 Plenary lecture: What is the role of allergy in asthma? Symposium: The dynamics of allergy march

88. British Thoracic Society (BTS) Summer Meeting, Cardiff, 30 June-01 July 2011 Symposium: Asthma and allergy: Nature or nurture

89. BSACI Annual Meeting, Nottingham 11-13 July 2011 Main symposium: Component-resolved diagnostic: Has it changed my clinical practice?

90. CIPPX-10th International Congress on Pediatric Pulmonology, Versailles 25-27/06/11 Plenary lecture: Before the first breath is taken: The role of in utero environment Pro/Con Debate: Immunotherapy in childhood asthma – Con

91. EAACI XX Annual Congress, Istanbul, 10-15 June 2011 Meet the expert: Wheezing phenotypes of early childhood: Solving the puzzle Pro-con session: Allergens need to enter lungs to cause asthma Symposium: Lifestyle, allergy and asthma

92. Respiratory Drug Delivery (RDD) Europe Congress, Berlin 3-6 May 2011 Plenary lecture: Genetics and environment: Their influence on rational drug therapy for asthma

93. Fourth World Asthma and COPD Forum, Paris, 30 April-2May 2011 Plenary lecture: Is asthma an allergic disease? Plenary lecture: Gene-environment interactions in the development of asthma

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94. WAO International Scientific Conference, Dubai 5-8 December 2010 Plenary lecture: Atopic eczema and respiratory allergy Symposium: Asthma phenotypes: A clinically useful concept? Symposium: Allergen avoidance strategies to reduce morbidity in asthma

95. Excellence in Paediatrics Conference, London 1-4 December 2010 Plenary lecture: How many diseases are there in asthma?

96. 60th Annual Congress of Japanese Society of Allergy, Tokyo 24-27 November 2010 Special Plenary lecture: Gene-environment interactions in the development of asthma and allergy Symposium: Is there a relationship between genotype and phenotype in asthma?

97. 43rd Annual Meeting of Chilean Society of Respiratory Diseases, Puyehue, 3-6 November 2010 Plenary lecture: Gene-environment interactions in the development of asthma Plenary lecture: Should wheezy infants be prescribed inhaled corticosteroids?

98. XXXIII Annual Congress of Argentine Association of Allergy and Clinical Immunology, Buenos Aires 11-14 August 2010 Plenary lecture: How could we reduce the burden of uncontrolled asthma? Paediatric Plenary lecture: Usefulness of cohort studies to establish the relationship between allergy and asthma Symposium: Efficacy of intranasal corticosteroids in ocular symptoms: A class effect?

99. CIPP IX-9th International Congress on Pediatric Pulmonology, Vienna 19-21 June ’10 Plenary lecture: Lessons from intervention studies Pro/Con Debate: Atopy is important in asthma – Pro

100. EAACI XIX Annual Congress, London, 5-9 June 2010 Post Graduate Course “Approach to the patient that does not respond well to asthma treatment”: Environmental Control Meet the expert: Allergen avoidance Symposium “Tolerance induction in children”: Pet allergy

101. 2nd International Congress on Exacerbations of Airway Disease, April 17-19, 2010, Miami Beach, Florida, USA Plenary lecture: Is there an asthma exacerbation prone phenotype in paediatric asthma?

102. 6th International Course on Paediatric Pulmonology, Dubrovnik, 9-11 April 2010 Plenary lecture: Genetics and wheezing disorders during childhood: the basics Plenary lecture: Severe chronic upper airway disease Plenary lecture: Inhaled corticosteroids in infancy Plenary lecture: Atopy - not all or nothing

103. IV World Immune Regulation Meeting, 29 March-1 April 2010, Davos, Switzerland Plenary lecture: Development of clinical asthma phenotypes by environmental triggers of innate immune response

104. WAO XXI World Allergy Congress 21, 6-10 December 2009, Buenos Aires, Argentina Plenary lecture: Achieving asthma control in a stepwise fashion Symposium: Can natural history of asthma be altered? Pro-Con session: Is asthma allergic disease: Pro

105. BTS Winter meeting, London, 2-4 December 2009 Joint BTS/BPRS symposium: Phenotype and genotype inter-relationships in childhood asthma

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106. EAACI 2009 Paediatric Allergy and Asthma Meeting, Venice 12-14 November 2009 Plenary lecture: Phenotypes of childhood asthma – Are they really related to genotypes?

107. 59th Annual Congress of the Japanese Society of Allergy, Akita, 28-31 October 2009 Plenary lecture: Gene-environment interactions in the development of asthma and allergic diseases Symposium: Is allergy a risk factor for early childhood asthma? Symposium: Prevention and early intervention in allergic diseases

108. 3rd Congress of the Respiratory Society of Bosnia and Herzegovina, Tuzla 22-25 October 2009 Plenary lecture: Why is asthma increasing?

109. Australian Society of Clinical Immunology and Allergy 20th Annual Scientific Meeting; 16-18 September 2009, Adelaide, South Australia Plenary lecture: Should wheezy infants be prescribed inhaled corticosteroids? Plenary lecture: Gene-environment interactions in the development of asthma and allergic diseases

110. EAACI XXVIII Annual Congress, Warsaw, 6-9 June 2009 Plenary lecture: Allergen exposure and genes Symposium: Does asthma start in early life Chairman: What have we learned from birth cohorts?

111. 1st Congress of the Croatian Society for Allergy and Clinical Immunology, Zagreb, 22-24 May 2009 Plenary lecture: Gene-environment interactions in the development of asthma

112. The Swedish Association of Otorhinolaryngology, Head & Neck Surgery Congress, Stockholm 13-15 May 2009 Plenary lecture: Gene-environment interactions in the development of asthma

113. Swiss Society of Allergology and Clinical Immunology & Swiss Society of Infectious Diseases joint congress, Geneva 19-21 March 2009 Main symposium: “The influence of respiratory viral infections on asthma”.

114. AAAAI 65th Annual Meeting, March 13-17 2009 , Washington DC Seminar: Immune Monitoring of Atopy and Inflammation in Infants and Children Pro – Con session: Skin Testing Is Superior to Serum Specific IgE Testing for Allergy Diagnosis (Con)

115. BTS Winter meeting, London, 3-5 December 2008 Joint BTS/BSACI Symposium: Exposure to allergens

116. 7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN), 13-15 November 2008, Dubrovnik Plenary lecture: Role of bacterial super-antigens in upper-lower airways interactions

117. XIX World Asthma Congress, Monte Carlo, 5-8 November 2008 Plenary lecture: Atopic march – Is it time for re-appraisal Symposium: Allergen avoidance

118. 5th Balkan Congress of Allergology and Clinical Immunology, Thessaloniki, 17-19 October 2008 Plenary lecture: Gene-environment interactions

119. American Academy of Otolaryngic Allergy Annual meeting, Chicago, 18-20 September 2008 Plenary lecture: Should we abandon the term “Atopic sensitization" in favour of

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“Quantitative allergy"? Plenary lecture: Gene-environment interactions in the development of atopy

120. 4th Slovenian Pneumology and Allergology Congress, Portoroz 14-16 Sep. 2008 Plenary lecture: Move the allergens

121. Controversies in Respiratory Medicine, Groningen, 12th September 2008 Plenary lecture: Move the allergens

122. BSACI Annual meeting, Loughborough 14-16 July 2008 Plenary Lecture and Debate: Allergen avoidance – Pro

123. BTS Summer Meeting 2008, York, 3-4 July 2008 Clinical Year in Review: Allergy

124. EAACI XXVII Annual Congress, Barcelona, 7-11 June 2008 Postgraduate course: Efficacy of prevention measures Symposium: Do objective measures correlate with symptom severity in the lower airways? Symposium: Allergen-specific Antibodies, Allergic Disease and Individual Susceptibility

125. RCPCH 12th Spring Meeting, York, 14-17 April 2008 Keynote Plenary Lecture: Should wheezy infants be given steroids?

126. VIII International Congress of Paediatric Pulmonology, Nice 29-31 March 2008 Plenary lecture: Gene-environment interactions? Plenary lecture: Food, allergy and asthma

127. AAAAI 64th Annual Meeting, February 23-27 2008, Philadelphia EOARD Interest Section Symposium: Manchester Asthma and Allergy Study Dinner Symposium: Just being sensitised means nothing in the context of allergy

128. WAO 20th World Allergy Congress, Bangkok, 1-6 December 2007 Symposium: How should we cope with the global burden of asthma? Debate: Allergen avoidance – Con Chairperson and Introductory lecturer: Asthma epidemiology

129. Highlights in Allergy and Respiratory Diseases, Genoa, 16-17 November 2007 Plenary Lecture: News on nasal corticosteroids

130. EAACI-ERS Paediatric Joint Meeting, Estoril, 20-23 October 2007 Plenary lecture: Primary prevention of asthma

131. Update on Asthma Symposium, Modena 28-29 September 2007 Plenary lecture: Inhaled corticosteroid in early childhood wheezing

132. Swiss Paediatric Society/Swiss Society for Infectious Diseases Joint Annual Congress, Zurich, 14-15 June 2007 Plenary “State of the Art” Lecture: Microbial exposure and allergy

133. EAACI XXVI Annual Congress, Gothenburg, 8-13 June 2007 Symposium: Clinical symptoms in relation to IgE- and IgG-antibodies: The role of confounding factors

134. Greek Society of Paediatric Allergy Annual Congress, Athens, 11-13 May 2007 Plenary Lecture: Management of childhood asthma

135. Croatian Paediatric Society Annual Congress, Split, 14-15 April 2007 Plenary Lecture: Gene-environment interactions in childhood asthma

136. South African Thoracic Society/South African Society of Allergy/Cystic Fibrosis Society of South Africa joint Congress, Cape Town 2-5 March 2007

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Plenary lecture: Allergen avoidance in established asthma Plenary lecture: Prediction and prevention of asthma

137. AAAAI 63rd Annual Meeting, February 23-27 2007, San Diego, California Seminar: Moderator – Stopping the atopic march Workshop-Q and A: World Allergy Forum – Is early exposure to allergens protective? Pro – Con session: Allergen avoidance is effective in the treatment of asthma (Con)

138. Japanese Society of Paediatric Allergy and Clinical Immunology Congress, Chiba/Tokyo 24-27 November 2006 Plenary lecture: Risk factors for asthma exacerbations Symposium: Prediction and prevention of allergic diseases

139. VII International Congress of Paediatric Pulmonology, Montreal 8-11 July 2006 Plenary lecture: What can we learn from genetic cohort studies?

140. EAACI XXV Annual Congress, Vienna, 10-14 June 2006 Symposium: Preventative measure Symposium: Allergen exposure and asthma epidemiology Symposium: What can we learn from IgE and IgG antibodies

141. ATS Annual Congress, San Diego, 20-24 May 2006 Pro-Con debate: Allergen avoidance is an essential part of asthma management – Con

142. Polish Society of Allergy and Clinical Immunology Annual Congress, Wisla 12-13 May 2006 Plenary lecture: The necessity of pharmacological studies in children

143. Turkish Society of Paediatric Respiratory Medicine Congress, Istanbul, 4-5 May 2006 Plenary lecture: Can we prevent asthma?

144. Danish Society of Paediatric Allergy and Immunology Annual meeting, Kolding, 23-24 April 2006 Plenary lecture: Prediction and prevention of asthma

145. Symposium “Challenging dogmas in allergy”, Berlin 21-23 April 2006 Plenary lecture: The role of environmental factors in the development of sensitisation and asthma

146. Dutch Society of Allergy and Clinical Immunology Annual Meeting, Aarhus, 22-23 March 2006 Plenary lecture: Prediction and prevention of allergic respiratory diseases

147. AAAAI 62nd Annual Meeting, March 3-7 2006, Miami, Florida Seminar: Allergen avoidance Workshop-Q and A: The Allergic march: Can it be stopped? Seminar: The role of proteases in allergic inflammation Workshop-Q & A: The relevance of allergen exposure to asthma prevalence and severity Symposium: International studies on asthma and allergy in children: Generating the next decade’s hypotheses

148. 2nd Convention on Controversies and New Developments in Allergy, Madrid, 17-18 February 2006 Keynote Lecture: Environment and respiratory allergic diseases

149. EAACI/Galen Symposium “Super-antigens in Respiratory Disease”, Ghent, 25-26 November 2005 Keynote Lecture: Impact of Staphylococcus aureus in early childhood

150. 23rd Congress of the Brazilian Society of Allergy and Immunology, 29 October-2 November 2005, Curitiba, Brazil

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Plenary lecture: Atopic march: prediction of allergic diseases Plenary lecture: Hygiene hypothesis – pros and cons Symposium: Clinical outcomes of allergen avoidance in asthma and rhinitis

151. Sixth Congress of the Croatian Respiratory Society, Opatija, 21-23 October 2005 Plenary lecture: Rationale for the combination therapy

152. Firestone Institute for Respiratory Health Opening Symposium, McMaster University, Hamilton, Canada 5-7 October 2005 Plenary lecture: Hygiene hypothesis

153. ERS 15th Annual Congress, Copenhagen, 9-13 September 2005 Meet the professor seminar - Allergen exposure and the development of allergic sensitization: facts and controversies

154. XIX International Congress of Clinical Chemistry/American Association for Clinical Chemistry 2005 Annual Meeting and Clinical Lab Expo, Orlando, FL, July 24-28 2005 Workshop: Importance of accurate, precise and quantitative tests for allergy diagnosis

155. BSACI Annual Meeting, Loughborough 18-20 July 2005 Chair: Plenary session Environmental influences on allergic sensitisation and asthma

156. XIX WAO and EAACI XXIV Congress, Munich, Germany 26 June-1 July 2005 Symposium: IgE analysis and the link between infections and allergy Meet the expert: How do we manage environmental control Debate of the day: Does mite avoidance work

157. Helminths as Modulators of Immunity Workshop, June 23-25 2005, Hamburg Invited Lecture: Changes in exercise-induced bronchospasm and atopy in Ghanaian schoolchildren

158. Wangener Tage und Padiatrientag 2005, June 10-11, Wangen, Germany Plenary Lecture: Prevention of allergic diseases

159. Turkish Thoracic Society World Asthma Day Symposium. May 4, Izmir, Turkey Plenary Lecture: Indoor allergens in established asthma

160. 17th Symposium of the Croatian Society for Paediatric Pulmonology, April 28-30, Plenary Lecture: Prevention of asthma

161. NVML Symposium Kind en allergie, 19 April 2005, Amersfoort, The Netherlands State of the art lecture: Development of allergic diseases

162. Italian Society of Paediatric Allergy and Immunology (SIAIP) 7th National Congress, April 6-9 2005, Rome, Italy Plenary Lecture: Prediction and prevention of allergic airway diseases

163. AAAAI 61st Annual Meeting, March 18-22 2005, San Antonio, Texas Pro/Con Debate: Are environmental control measures helpful in treating allergic respiratory diseases? EORD Interest Section Forum: Clinical outcomes of allergen avoidance: What have we learned from case-control and prospective studies Seminar: Hygiene hypothesis for asthma: Pros and cons Workshop – Q and A: Clinical outcomes of allergen avoidance in the MAAS cohort Symposium: Learning from intervention studies

164. Airways Extra Second National Conference, 13 January 2005, Manchester Plenary lecture: Allergen avoidance: Does it work?

165. Turkish Thoracic Society Meeting, Istanbul, 3-4 December 2004 Plenary Lecture: Environment and asthma

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Plenary Lecture: Allergen avoidance in the treatment of asthma and rhinitis Pro and con session: Can we prevent asthma: Pro

166. Highlights in Allergy and Respiratory Diseases, Genoa, Italy, 12-13 November 2004 Plenary Lecture: Allergen exposure and atopy development

167. Canadian Society of Allergy and Clinical Immunology Annual Congress, Ottawa, 22-24 October 2004 Pro and con session: Hygiene: Just an innocent passenger in allergy?

168. University of Ohio Health Seminar Series, Cincinnati, 20th October 2004 Plenary lecture: Primary prevention of asthma and allergic disorders - Lessons from Manchester Asthma and Allergy Study

169. Croatian Society of Allergy and Clinical Immunology Annual Meeting, Dubrovnik, 25 September 2004 Plenary lecture: Primary prevention of asthma

170. Chilean Society of Allergy and Clinical Immunology Annual Meeting, Santiago de Chile, 31 August – 2 September 2004 Plenary lecture: Atopic march Plenary lecture: Primary prevention of allergic diseases

171. EAACI XXIII Congress, Amsterdam, The Netherlands 12-16 June 2004 Junior Members Association Educational Session: How to give a scientific presentation Postgraduate Symposium: Inhalant allergy - Consequences of multisensitisation and exposure Chiron Project Session: Hygiene hypothesis Main symposium: Manchester cohort

172. Symposium “Addressing the allergy epidemic”, Uppsala, Sweden, May 6-8 2004 Plenary Lecture: Allergy and infection – understanding their relationship

173. Symposium “Immunology and immunotherapy of asthma”, Aberdeen 29 April 2004 Plenary Lecture: Primary prevention of asthma: efficiency of measures to change the indoor environment

174. Symposium on Specific Allergy (SOSA), London 22-24 April 2004 Plenary Lecture: Why is primary prevention so difficult?

175. AAAAI 60th Annual Meeting, San Francisco, 19-23 March 2004 Seminar: Hygiene hypothesis for asthma: Pros and cons Course: Efficiency of measures to change the indoor environment Postgraduate symposium: Early environmental exposure to animals: Effects on sensitisation and asthma

176. 6th International Congress on Paediatric Pulmonology, Lisbon, Feb 28-March 2, 2004 Plenary lecture: Manchester Cohort Plenary lecture: The role of allergen avoidance in primary and secondary prevention

177. Airways Extra First National Conference, 4 November 2003, Birmingham Symposium: Usefulness of house dust mite avoidance: The bottom line.

178. 3rd Balkan Congress of Allergy & Clinical Immunology, Istanbul 11-14 October 2003 Plenary lecture: Update on allergic sensitisation Main symposium: Sensitisation and asthma phenotypes

179. WAO Congress, Vancouver, Canada 6-12 September 2003 Lunch Seminar: Allergen Avoidance Debate of the day: Kill the cat, or buy one? Parallel Symposium: Can allergen avoidance in home provide protection?

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180. BSACI Annual Meeting, Nottingham 30 June- 2 July 2003 Chairman of the Plenary Session: Early life influences on allergy development

181. BTS Summer Meeting 2002, Cardiff 26-26 June 2003 Main Symposium: Can we achieve a reduction in personal allergen exposure?

182. EAACI XXII Congress, Paris, France 7-11 June 2003 Plenary Lecture: Can allergy be prevented? Meet the Professor Seminar: Primary prevention of allergy Main Symposium: Combination effects of allergen exposure and infection in allergic exacerbations

183. Symposium “Exacerbations in COPD and Asthma”, Lund, Sweden, 10-11 April 2003 Plenary lecture: Viruses and allergens in asthma exacerbations

184. Royal College of Paediatrics and Child Health Meeting, York, 7-10 April 2003 Plenary Lecture: Too dirty or clean: Why are asthma and allergies increasing?

185. AAAAI 59th Annual Meeting, Denver, 7-12 March 2003 Postgraduate Symposium: Allergen avoidance from birth: Clinical outcome Breakfast Seminar: Hygiene hypothesis for asthma: Pros and cons Chairman: Hygiene hypothesis and environmental risk factors for asthma

186. Association for Respiratory Technology and Physiology Conference 2003, Stratford-upon-Avon, 16-18 January 2003 Plenary lecture: Exercise-induced bronchospasm

187. BTS Winter Meeting 2002, London 4-6 December 2002Major Symposium: Indoor allergens and asthma: The good, the bad and the ugly.

188. BSI/BSACI Congress, Harrogate 4-6 December 2002 Main Symposium - The early influences on development of the immune response

189. Third European Conference on Paediatric Asthma, London 28-29 October 2002 Plenary lecture: Prenatal events Masterclass: Allergen Avoidance Session Chairman: Importance of gastro-oesophageal reflux in paediatric asthma

190. Third Congress of the Croatian Respiratory Society, Opatija, 17-19 October 2002 Plenary lecture: Prevention of asthmaRound table: Inhaled corticosteroids – Systemic side effects

191. ERS 12th Annual Congress, Stockholm, 13-18 September 2002Clinical Year in Review: Hot topic - Environmental manipulation around birth: Does it influence immune system

192. MRC GPRF Annual Conference, University of Warwick 2-3 September 2002 Plenary Lecture: Secondary Mite Allergen Control (SMAC) study – final results

193. EAACI Clinical Update Course, Palic, Serbia, 12-16 June 2002 Plenary Lecture: Primary prevention of asthma and allergic disorders Meet the professor seminar: Inhaled corticosteroids – Systemic side effects

194. EAACI XXI Congress, Naples, Italy 1-5 June 2002 Main Seminar: Primary prevention of allergic disease Chiron Project: Too dirty or too clean: Why are asthma and allergic diseases increasing?

195. Turkish Thoracic Society 5th Annual Congress, Antalya, Turkey, 24-27 April 2002. Meet the professor symposium: Allergen avoidance in allergic asthma Plenary lecture: Environmental allergen exposure and the development of asthma

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196. 41st Swineford Allergy Conference, University of Virginia, USA, 12-13 April 2002 Plenary lecture: The case for primary prevention

197. AAAAI 58th Annual Meeting, New York, 1-6 March 2002 Main Symposium: Allergen abatement - What really works: Animal allergen Postgraduate Symposium: Environmental risk factors for the development of allergy: The prospects for primary prevention Symposium Allergen avoidance in the treatment of asthma: Prospective cohorts of allergen avoidance

198. Annual Asthma and Allergy Meeting for Danish Paediatricians, Kolding, February 24-25 2002 Plenary lecture: Primary prevention of allergic diseases and asthma – Environmental Measures

199. First joint Meeting of Cypriot Society for Paediatric Respiratory Medicine/Greek Society for Paediatric Respiratory Medicine, Nicosia 12-13 January 2002 Plenary lecture: Too dirty or too clean: Why are asthma and allergic diseases increasing?

200. Gemma Gherson Symposium “Environment and allergy””, Pavia, October 5-6 2001 Plenary lecture: Indoor allergens and allergic disease

201. ERS 11th Annual Congress, Berlin 22-26 September 2001 Major Symposium: Allergen avoidance: Is it effective? Parallel session: Early sensitisation in children – antenatal or postnatal exposure?

202. Argentinean Society of Allergy and Clinical Immunology 25th Annual Meeting, Buenos Aires 17-21 August 2001 Plenary lecture: Treatment of asthma in childhood Plenary lecture: Does early allergen exposure enhance or prevent asthma Main symposium: Inhaled corticosteroids – Systemic side effects Main symposium: Difficult to control allergy: Environmental control

203. BSACI Annual Meeting, Nottingham 9-11 July 2001 Plenary lecture: Is allergen avoidance effective? – Pro

204. EAACI 20th Congress, Berlin 9-13 May 2001 Main symposium: Does early allergen exposure enhance or prevent asthma

205. The Institute of Allergy Workshop: The Allergic March, Berlin May 8-9 2001 Plenary Lecture: Intervention studies: The Manchester Asthma and Allergy Study

206. AAAAI 57th Annual Meeting, New Orleans, 18-23 March 2001 Postgraduate Symposium: Allergen abatement - What really works: Animal allergens Main Symposium Environmental risk factors for the development of allergy: The prospects for primary prevention

207. Kuwait Institute for Medical Specialisation: Kuwait 10-11 February 2001 Plenary Lecture: Indoor environment and asthma Plenary Lecture: Allergen Avoidance

208. Institute Pasteur Euroconference “Hygiene and Health”, 25-27 January 2001, Paris Plenary lecture: Environmental allergen exposure and asthma: Prospects for primary prevention

209. Second European Conference on Paediatric Asthma, 23-24 November 2000, London Plenary lecture: Reducing the effects of inhaled allergens

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210. International Society of Internal Medicine: Symposium “Emergencies in Internal Medicine”, 30 September-3 October 2000, Dubrovnik, Croatia Plenary Lecture: Asthma management

211. MRC GPRF Annual Conference, University of Warwick 11-12 September 2000 Plenary Lecture: Management of asthma by non-pharmacological means

212. EAACI 19th Congress, Lisbon 1-5 July 2000 Main Symposium: Maternal allergen exposure and sensitisation related to immune response in the offspring Main Symposium: Alternative theories explaining the rising trend of atopy Main Symposium: Allergen avoidance - Practical measures

213. BTS Summer Meeting, 29-30 June 2000, Harrogate Main symposium: Minimising indoor pollution

214. AAAAI 56th Annual Meeting, March 3-8 2000, San Diego Parallel session: Environmental risk factors for childhood asthma

215. Academy of Medical Sciences, Croatia: Symposium “Environmental Influences on Respiratory System”, Zagreb, Croatia, 18th February 2000 Plenary lecture: Prospects for primary prevention of asthma

216. BSI/BSACI Congress, Harrogate 29 November-3 December 1999 Main Symposium: Prospects for primary prevention

217. The Royal College of Physicians; 39th St. Andrew’s day festival symposium on respiratory medicine, Edinburgh 2nd-3rd December 1999 Invited speaker: Can antigen eradication solve asthma

218. 2nd International Meeting of Dipartmento Multizonale di Milano, November 12-13 ‘99 Plenary lecture: The domestic allergens in dust and air

219. EAACI XVIII Congress, Brussels, Belgium, 3-7 July 1999 Major Symposium: Manchester Asthma and Allergy Study

220. National Asthma Campaign International Congress "Asthma: The agenda for the next millennium", London 8-10 June 1999 Main symposium: Pets

221. American Academy of Allergy, Asthma and Immunology (AAAAI) 55th Annual Meeting, February 26-March 3 1999, Orlando, Florida Parallel session: Environmental risk factors - prospects for prevention

222. World Asthma Meeting, Barcelona, Spain, 10-13 December 1998. Major Symposium "Risk factors for asthma": Allergens

223. International Conference on Paediatric Asthma, Maastricht, 3-4 March 1998. Masterclass "House dust mite exposure and avoidance in early life".

224. National Conference on Asthma Education & Management, London, 24-25 Feb ‘98. Main symposium: Indoor and outdoor allergens

225. International Workshop “The House Dust Mite: Its Biology and Role in Allergy”. Oslo, Norway, September 4-7 1997. Plenary lecture: Risk levels for mite allergens: Are they meaningful? Plenary lecture: Importance of indoor allergens in the induction of allergy and elicitation of allergic disease: Is there a hierarchy of indoor allergens?

226. American Thoracic Society (ATS) Conference, San Francisco, May 16-21 1997 Sunrise Seminar: "Prospects for primary allergen avoidance"

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227. World Congress of the World Small Animal Veterinary Association, Birmingham, April 2-6 1997. Parallel session: Atopy: The human perspective.

228. ERS Symposium "Asthma and the Environment", Wiesbaden, November 7-8 1996. Plenary lecture: Indoor allergen exposure is the primary cause of asthma

229. European Respiratory Society (ERS) Congress, Stockholm, September 7-11 1996 Chairman of the session "Allergens and other exogenous factors in childhood asthma"

230. Nederlands Astmacentrum Davos, Annual Meeting "Astma en andere IgE-gemedieerde aandoeningen: nieuwe inzichten", Davos, February 11-17 1996. Plenary lecture: Causal factors in the increasing incidence of IgE-related diseases Plenary lecture: Allergen avoidance: A realistic approach.

231. Societa Italiana di Allergologia ed Immunologia Clinica, Meeting Ambiente ed Allergopatie, Naples October 26-27 1995. Plenary Lecture: Indoor environment and development of respiratory allergy.

EDITORSHIP: JOURNAL

Associate Editor

2017-2022 American Journal of Respiratory and Critical Care Medicine

2010-2015 Thorax

International Advisory Board

2017-2022 The Lancet Child and Adolescent Health

2017-2021 Pediatric Respirology and Critical Care Medicine

Editorial Board2016-2019 Frontiers in Medicine; Review Editor, Pulmonary Medicine Section

2017-2022 Pediatric Allergy and Immunology

2015-2018 Thorax

2015-2019 Pulmonary Therapy

2014-2018 Asthma Research and Practice

2004-2017 PLoS Medicine

2010-present Acta Medica Academica

2014-present Primary Care Respiratory Medicine

2012-2015 Clinical and Translational Allergy

2010-2015 Bosnian Journal of Basic Medical Sciences

2010-2013 Annals of Respiratory Medicine

2010-2012 Treatment Strategies - Respiratory

2006-2014 Primary Care Respiratory Journal

2005-2010 Pediatric Allergy and Immunology

2004-2009 Allergy

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2003-2006 Annals of Allergy, Asthma and Immunology

2003-2006 Allergy Hypersensitivity Asthma

2000-2003 Clinical and Experimental Allergy

Editorship: NewsletterEditor 1999-2000 British Society of Allergy and Clinical Immunology Newsletter

4. SUPERVISION OF RESEARCH STUDENTS

Supervision to completion:PhD/MDPhD (2019) – Dr Matea Deliu; Dimensions of respiratory symptoms during childhood; The University of Manchester

PhD (2018) – Miss Rebecca Howard; Distinguishing asthma and allergy endotypes using longitudinal probabilistic modelling; The University of Manchester (Co-supervisor)

PhD (2014) - Danielle Belgrave; Probabilistic causal and hypothesis-generating models for asthma and allergies developing in childhood (Co-supervisor)

PhD (2013) - Jenny Hankinson; Thesis: “The Role of VEGF in Lung Function” (Co-supervisor)

PhD (2010) – Dr Aida Semic-Jusufagic; Thesis: “Antibiotic use in infancy and development of childhood asthma”

PhD (2010) – Dr Susana Marinho; Thesis: “Genetic and environmental factors in asthma in adults”

PhD (2010) - Sumiya Patel; Thesis: “The role of diet in childhood wheeze and asthma” (Co-supervisor)

PhD (2009) - Dr Angela Simpson; Thesis: “Genetic and environmental factors in asthma and allergic diseases” PhD (2009) – Dr Nicolaos Nicolaou; Thesis: “The predictors of clinical reactivity to peanut within the context of a population-based birth cohort study”

MD (2006) – Dr Stephen Langley; Thesis: “Assessment of asthmatic patients longitudinally”

PhD (2006) - Dr Claudia Gore; Thesis: “Atopic Dermatitis in Infancy”

PhD (2005) –Lesley Lowe; Thesis: “Pulmonary function in early life: genetic predisposition, environmental exposure and the development of asthma”

PhD (2004) – Dr Robin Gore; Thesis: “Nasal air sampling and the quantification of domestic aeroallergen exposure” (Co-supervisor)

PhD (2004) – Elizabeth Hedley; Thesis: “Optimisation of mRNA techniques and their application to the investigation of immune parameters in atopic diseases” (Co-supervisor)

PhD (2003) – Dr Mahdi al Mousawi; Thesis: “Environmental, family and immunological factors associated with asthma in Kuwait” (Co-supervisor)

MD (2002) – Dr Clare Murray; Thesis: “Environmental allergens and childhood asthma”

MD (2001) – Dr Spyros Pipis; Thesis: “Lung function at one month of age as a risk factor for infant respiratory symptoms in a high-risk population”

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MD (2000) – Dr Emmanuel OD Addo Yobo; Thesis: Asthma in Ghanaian school children: Prevalence and seasonal variation of exercise-induced bronchospasm and the importance of atopy and other risk factors” (Co-supervisor)

MSc/MRes/MPhilMSc (2018) – Dr Abigail Walker; Subtypes of paediatric rhinitis; (MSc in Allergy, Imperial College London)

MSc (2015) - Dr Gautam Sain; The Relationship between exposure to beta-glucan and the development of asthma and atopy (MSc in Allergy, Imperial College London)

MRes (2015) - Dr Iso Precious Oloyede; The role of urinary EPX at age 3 years as a predictor of the subsequent development of asthma/allergic diseases by age 16 years

MSc (2014) – Dr James Hinds; Testing for sensitisation to perennial inhalant allergens in children with asthma in primary care (MSc in Allergy; Imperial College London)

MPhil (2012) - Naillah Brown; Thesis: “Longitudinal associates of pulmonary function in children aged 3 to 11 within a population birth cohort study” (Co-supervisor)

MPhil (2006) – Dr Nicolaos Nicolaou; Thesis: “Exhaled breath condensate pH within the context of a whole population birth cohort”

MSc (2000) – Nadia Ahmed; Thesis: “A novel semi-quantitative method for assessing environmental allergen exposure” (Manchester Metropolitan University)

MPhil (1999) –Claire Louise Hallam; Thesis: “Environmental exposure to indoor allergens, sensitisation and the expression of allergic disease”

Currently supervising:PhD (2018-2021) – Eteri Bakhsoliani, Imperial College London

PhD (2018-2021) – Hans-Joachim Sonntag, Imperial College London

MSc (2018-2019) – Dr Constantinos Kotsapas, MSc in Allergy, Imperial College London

5. ORGANIZATION, PROMOTION AND MANAGEMENT OF RESEARCH

Service as an external examiner or as a referee

2019 External Advisory Committee: The Inner City Asthma Consortium’s URECA study; NIAID, NIH, US

2015 External Referee, Austrian Science Funds (FWF – Der Wissenschaftsfonds): Interim Evaluation of the Special Research Programme (SFB) 'Towards prevention and therapy of allergy'

2013 External review of the Master’s Courses in the Department of Medicine, Imperial College London

2012 External examiner and assessor in Paediatrics: Chinese University of Hong Kong

2011-2012 Irish Health Research Board (HRB): Member, Selection Committee for Clinician Scientist Award

2007-2011 External Examiner, MSc in Allergy, University of Southampton

Grant reviews

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Medical Research Council; The Wellcome Trust; NIHR; Asthma UK; The British Lung Foundation; Action Research; Scottish Executive Health Department; Nederlands Astma Fonds; The Netherlands Organisation for Health Research and Development; The Netherlands Organisation for Scientific Research; Health Research Council of New Zealand; Spanish National Agency for Scientific Evaluation (ANEP)

External examination of post-graduate candidates London School of Hygiene & Tropical Medicine: PhD Thesis “Urbanisation and childhood

asthma in a developing region of Latin-America: a cross sectional analysis in north-eastern Ecuador - Rodrigo Alejandro Rodriguez Alvarado, December 2018

King’s College London: PhD Thesis “How do hygiene-related exposures influence the development of food allergy?” – Dr Thomas Marrs, 22 My 2018

University of Nottingham: PhD Thesis “Asthma and Allergic Disease: Their relation with Necator Americanus and other helminth infections” – Dr Johanna Feary, 19th October 2011

University of Copenhagen, Faculty of Health Sciences: PhD Thesis “Physical activity in preschool children: characteristic and association with lung function” - Martin Brasholt, 2010

University of Nottingham: PhD Thesis “Helminths and allergic diseases in Vietnam” – Dr Carsten Flohr, 19th November 2007

University of Vienna, Austria: PhD Thesis “Characterisation of milk allergens” – Ulrike Schulmeister, 17th September 2007

University of Nottingham: PhD Thesis “A study of prevalence of asthma and atopy in Jimma, south west Ethiopia” – Haile Yemaneberhan, 16th May 2005

University of Nottingham: MD Thesis “Diet and Asthma” - Andrew Fogarty, 13th May 2003

University of Umea, Sweden: PhD Thesis "Molecular Epidemiology of allergen exposure, sensitisation and asthma in school children" - Matthew S Perzanowski, 10 th January 2003

National University of Ireland, Galway: MD Thesis “Bronchial asthma: The relationship between airway dehydratation and bronchoconstriction” – Edward Daniel Moloney, June 2002

Imperial College London, PhD thesis “House dust mites and asthma” – Heidi Chung, 5th

October 2000

RESEARCH PROJECTS AND COLLABORATIONSStudy Team for Early Life Asthma Research Network (STELAR)At the core of my research activity is the MRC-funded Study Team for Early Life Asthma Research Network (STELAR). STELAR is a network of representatives of the 5 UK birth cohort studies plus other experts. The network successfully submitted an application to MRC to fund clinical follow up of the 3 younger cohorts with common clinical outcomes at age 11-13 years. We have subsequently secured MRC funding for further follow up of the cohorts, and to create an Asthma eLab as a secure, shared web-based environment and a repository for the anonymised data for all five UK birth cohorts on asthma/allergies. Collaborators in STELAR include Prof Graham Devereux and Dr Steve Turner, University of Aberdeen, principal investigators of the SEATON cohort; Prof Paul Cullinan, Imperial College London, principal investigators of the Ashford cohort; Prof John Henderson, University of Bristol, lead

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investigator for respiratory in ALSPAC birth cohort; Prof Hasan Arshad and Prof Graham Roberts, University of Southampton, principle investigators on Isle of Wight Study.

MRC/BBSRC Flagship Consortium in Systems Immunology of the Human Life Course: Phenotyping immune responses in asthma and respiratory infections - a systems approach to understanding changes from childhood to adulthood. We combine world-leading expertise in infection and immunity (Imperial), a population based birth cohort study (MAAS) and computational analysis (HeRC) to identify novel mechanisms related to increased susceptibility to asthma, allergies and RTIs.

EAGLE Consortium (Early Genetics and Life course Epidemiology Consortium for Asthma Allergy and Atopy): We are a member centre in a large consortium with >10 cohorts internationally. The objective of this consortium if to identify common variants underlying common phenotypes such as atopy and eczema. The first manuscript was published in Nature Genetics in 2012, followed by 4 further Nature Genetics papers in 2013-5. Microsoft Research, Cambridge and Northwest Institute for Bio-Health Informatics (NIBHI): Prof Chris Bishop and Dr John Winn, Microsoft Research, Cambridge; Prof Iain Buchan, Professor of Public Health Informatics and Director of the (NIBHI). We obtained externals funding form Microsoft Research to perform whole genome genotyping of MAAS cohort ($250,000). Collaboration on the application of machine learning techniques to large datasets to re-define phenotypes in asthma and allergies. Joint grants and publications.

Other major academic collaborations in the UK and abroad(1) UKProfessor Sebastian L Jonhston (National Heart and Lung Institute, Imperial College London); joint funding and publications:

1. MRC/BBSRC Flagship Consortium in Systems Immunology of the Human Life Course

2. Susceptibility to infection: Markers and mechanisms (funded by the JP Moulton Charitable Foundation)

3. Risk Factors for hospital admission with asthma in children and adults

Professor David Strachan (Professor of Epidemiology, Department of Public Health Sciences, St George's Hospital Medical School, London); joint funding and publications:

1. The National Study on the effect of mite allergen avoidance by the use of allergen impermeable bedding on asthma control in adults (Funding NHS R&D)

2. Asthma and allergy in farmers in the UK (funded by the Wellcome Trust)

3. Asthma and Atopy in Urban and Rural Ghanaian Children (funded by the Wellcome Trust)

Dr Madge R Vickers (MRC General Practice Research Framework); joint funding and publications:

1. The National Study on the effect of mite allergen avoidance by the use of allergen impermeable bedding on asthma control in adults (Funded by NHS R&D)

Professor Janet Stocks (Professor of Respiratory Physiology, Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, University College London, Institute of Child Health, London); joint funding and publications:

1. Growing lungs at UCL Institute of Child Health (Funded by Asthma UK) www.ich.ucl.ac.uk/ich/academicunits/growinglungs/UnitStaffList;

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http://www.ich.ucl.ac.uk/ich/academicunits/growinglungs/UnitStaffList

Professor John Britton (Professor of Respiratory Medicine, Division of Respiratory Medicine, University of Nottingham); joint funding and publications:

1. Risk factors for wheeze in Ethiopia (Funded by the National Asthma Campaign and Wellcome Trust)

Professor Stephen Holgate (MRC Clinical Professor of Immunopharmacology,University of Southampton); joint publications:

1. ADAM 33 polymorphisms and lung function in early life

(2) AbroadFernando Martinez, Regents Professor and Director Arizona Respiratory Center, University of Arizona, USA, Visiting professor to the Respiratory research group, University of Manchester, 2006-2009: On-going collaboration on the risk factors for asthma, gene-environment interactions, functional genomics of VEGF-A and in epigenetic mechanisms in allergic disease; Joint publications.

Prof Hans Bisgaard, the Danish Paediatric Asthma Centre, Copenhagen, Denmark; Genetics of asthma and allergy; Joint publications.

Professor Patrick Holt, University of Western Australia, Perth: Development of immune response during childhood; Joint publications.

Professor Staffan Ahlstead, Karolinska Institute, Stockholm, Sweden; IgE quantification in allergic disease; Joint funding, patent and publications.

Professor Claus Bachert, University oh Ghent, Belgium; The role of Staphylococcal IgE in the development of allergic disease; Joint publications.

Professor Martin Chapman (Asthma and Allergic Diseases Center, University of Virginia, Charlottesville VA 22109, USA); Measurement of environmental allergen exposure; Joint publications.

Dr Euan Tovey (IRM Allergen Group, Dept of Medicine, DO6, University of Sydney, NSW 2006, Australia); Long-term collaborative projects on the novel methods of assessing personal inhaled allergen exposure; Joint publications.

Dr Ronald van Ree (Central Blood Laboratory, Amsterdam, The Netherlands); Development of certified reference materials for allergenic products and validation of methods for their quantification (CREATE) – Funded by the European Union The Fifth Framework Programme; Joint funding and publications.

Dr EOD Addo-Yobo (Department of Child Health, Komfo Anokye Teaching Hospital P.O. Box 1934, Kumasi, Ghana); 1. Prevalence of asthma in the urban and rural Ghanaian children (funded by the Tropical Health and Education Trust); 2. Risk factors for asthma in urban Ghanaian children (funded by the Tropical Health and Education Trust); 3. Asthma and Atopy in Urban and Rural Ghanaian Children (Funded by the Wellcome Trust); Joint funding and publications.

Professor Neda Aberle, University of Osijek, Croatia; Gene/environment interactions in the development of asthma and allergic sensitisation in Croatian children (funded by the Moulton Charitable Trust); Joint funding and publications.

Dr Asja Stipic-Markovic (Department of Respiratory Medicine, University Hospital “Sveti Duh”, Zagreb, Croatia); ISAAC Phase II in Croatia; Joint publications.

Dr Abdurahman Al-Dowisan (Kuwait Allergy Centre, Salamyia, Kuwait); Risk factors for asthma in Kuwait (funded by the Kuwaiti Foundation for the Advancement of Science - KFAS); Joint funding and publications.

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Other media: Research

1. BBC North West Tonight, 3rd July 2014; Interview on 20 years of Manchester Asthma and Allergy Study

2. Radio Wythenshawe, 13 June 2013; Interview on Clinical allergy services at UHSM

3. Manchester Evening News, 14th November 2012

4. Estonian television, 4th August 2012; Interview on the causes of the increase in allergic diseases

5. BBC Radio Manchester, 5th July 2012 11:15 am, Interview

6. Manchester Evening News, 17th February 2011: Sending a child to nursery “could increase the risk of asthma”

7. BBC Radio Manchester, 10th July 2010 11:15 am, Interview

8. BBC Radio Manchester, 6th May 2010 10:45 am, Interview

9. BBC Radio Manchester, 10th March 2010 11:45 am, Interview

10. Manchester Evening News, 5th March 2010: Offer not to be sneezed at for hay fever kids

11. St Louis Post, USA, 16th February 2010: Is your child’s food allergy real?

12. The Cleveland Plain Dealer (USA), 15th February 2010: New diagnostic test may make it easier to identify peanut allergies in children

13. The Wall Street Journal (Europe), 27th January 2010: Is your kid truly allergic to peanut?

14. The Wall Street Journal (US), 26th January 2010: Is your kid truly allergic? Tests add to food confusion

15. Trafford Metro News, 22nd January 2010: “Nut allergy” girl given all clear

16. BBC Radio Manchester, 19th January 2010, 10:15 am, Interview

17. Corus Radio Network (CNN radio affiliate in Canada), 15th January 2010: 20 minutes live interview

18. Fox News, 14th January 2010: Peanut allergies less common that tests suggest

19. The Guardian, 14th January 2010: Standard tests over-diagnose peanut allergy

20. Brooklyn Daily Eagle, 13th January 2010: Better test for peanut allergies in the pipeline

21. Reuters, 13th January 2010: Peanut allergies less common than tests suggest

22. Mirror, 12th January 2010: Why our peanut allergy is over the top

23. BBC Newsround, 12th January 2010, 17:00 GMT: Ricky investigates a new nut allergy test (Interview)

24. CTV Canada, 12th January 2010: More accurate peanut allergy test could be on the way

25. The Globe and Mail (Canada), 11th January 2010: New test may detect peanut allergies

26. Manchester Evening News, 11th January 2010: Nut allergy “myth” is cracked

27. The Independent, 11th January 2010: Fewer people have real peanut allergy than previously thought

28. Nursing times, 11th January 2010: Fewer cases of “real” peanut allergy than previously thought

29. Daily Mirror, 11th January 2010: New test predicts whether kids will have nut allergies

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30. Daily Telegraph, 11th January 2010: Fewer people have real peanut allergy than previously thought

31. Manchester Evening News, 3rd December 2008: Coroner warns of allergy “lottery”

32. The New York Times, 15th September 2008: Childhood: Day Care May Offer Asthma Protection

33. Manchester Evening News, 12th September 2008: Going to nursery can stop children getting asthma

34. The Daily Telegraph, 12th September 2008: Children at nursery 'less likely to get asthma'

35. Manchester Evening News, 1st September 2008: £ 60,000 centre to pilot care for allergy sufferers

36. BBC Radio Manchester, 9th May 2008, Hay fever

37. Jutarnji List, Croatia, 31st October 2007: page 37 A3

38. Reuters, 21st May 2007: S Aureus enterotoxin sensitivity linked to allergic disease

39. Medical News Today, 28th Feb 2007: What Is Known About Asthma In Africa

40. Manchester Metro News, 17th February 2006: Special vacuums won’t stop dust mites, say boffins

41. Manchester Evening News, 18th July 2005: Summer allergy that’s not to be sneezed at

42. Croatian National TV network, 30th January 2005: New treatments for asthma

43. Radio Zagreb, Croatia, 19th January 2005: New developments in the treatment of asthma

44. Manchester Evening News, 3rd November 2004: Rise and rise of the killer allergy.

45. WebMD News, 29th September 2004: Avoiding cats, dust doesn't prevent asthma

46. Croatian TV News Bulletin, 25th September 2004: Interview on the importance of pollen monitoring station for patients with allergic disease

47. HealthScoutNews, 7th March 2004: Vacuuming makes the dander grander

48. Nature, 9th October 2003: Hepatitis-like drugs could treat allergies

49. The Times, 1st October 2003: Asthma families

50. Country nurse, 16th September 2003: Spring allergy season

51. Vancouver Sun, 10th September 2003: Allergists scratch heads over cat data – Researchers wrestle with question of whether cats cause allergies

52. BBC 1 North West Tonight, 25th July 2003: The Lack of Allergy Services in the North-West

53. CTV News, Canada, 17th July 2003: Mite-proof beds offer no allergy relief

54. Health 24, 17th July 2003: Covers no match for mites

55. Associated Press Health News, 17th July 2003: Mite-proof bed covers no relief

56. Albert Einstein Healthcare Network, 16th July 2003: Bed covers no match for mighty mites

57. Canadian Press, 16th July 2003: Mite-proof bed covering bring no relief for allergies

58. Allergies relief, 16th July 2003: Bed covers no match for mighty mites

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59. Discovery Channel Broadcast, 23rd September 2002 (two-monthly intervals thereafter): Human wildlife series - The meaning of lice

60. New Scientist, 29th March 2002: Severe asthma linked to common cold

61. BBC 1 North West Tonight, 29th March 2002: Allergens and viruses act together to exacerbate asthma

62. Doctors Guide to Medical & Other News, 28th March 2002: Allergen-virus combo heightens asthma hospital admissions

63. The Daily Telegraph, 6th November 2001: Family turns tables on dust mites – The results of an asthma study that concentrate on environmental factors look promising

64. Health minutes, 13th August 2001: Getting rid of dust mites

65. BBC News, 4th January 2001: Pollution could cause asthma

66. BBC News, 12th December 2000: Mouse allergy to blame for asthma

67. ITV News North West, 20th November 2000: Dog allergens gets everywhere

68. Doctors Guide to Medical & Other News, 13th December 1999: Synthetic pillows may not be best for allergies

69. BBC News, 13th December 1999: Feather pillows better for asthmatics

70. Doctor’s guide, 13th December 1999: Synthetic pillows may not be best for allergies

71. ITV News, 14th April 1999: Air Pollution and Asthma

72. BBC News, 27th January 1998: Cats spread asthma - report

6. CLINICAL RESPONSIBILITIESI am a Clinical Professor of paediatric allergy at the children's allergy department at St Mary’s Hospital. This is one of very few centres in the UK to provide a comprehensive service to children with allergic disease, with particular experience in treating complex, multi-system allergic disease. We have developed and are implementing a unique integrated care pathway programme with training and support for carers, nurseries, schools and health professionals to ensure consistent delivery of the highest standard of care (for detailed information please see https://www.imperial.nhs.uk/our-services/childrens-services/childrens-allergy)

For details of the UHSM Allergy Centre in Manchester which I developed, please see http://www.uhsm.nhs.uk/allergy/Pages/AllergyCentreHome.aspx. I have initiated a much needed Drug Allergy Investigation Service, which provides testing for a variety of common drugs including antibiotics, contrast media and general and local anaesthetics. The Allergy Centre offers a comprehensive immunotherapy service for children and adults, and wide range of day challenges including oral and intravenous drug challenges and food challenges.

I have influenced the development of national policy on how allergy can be better dealt with in the NHS through the membership of the National Allergy Advisory Group and presented key evidence to the House of Lords Enquiry into Allergy Services that led to the implementation of a new National Pilot Allergy Centre. In August 2008 the North West SHA was appointed to lead this project. We created a NW Allergy & Clinical Immunology Network; I am a member of the Network Strategy Board which co-ordinates the bringing together of tertiary allergy providers and the supporting services in primary and secondary care to form an inter-city allergy networked centre. My leadership role in the North West Allergy Network resulted in the improved access, experience and outcomes for patients with allergies and will influence the development and implementation of national policy for the provision of allergy healthcare across the UK.

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http://www.uhsm.nhs.uk/allergy/Pages/AllergyCentreHome.aspx

https://www.imperial.nhs.uk/our-services/childrens-services/childrens-allergy

I made major contribution to the training in allergy as a Programme Director for Allergy in the NW Deanery and RCP Regional Specialty Advisor.

C. OTHER EVIDENCE OF ACADEMIC AND PROFESSIONAL STANDING

1. PROFESSIONAL ADVISORY OR CONSULTANCY WORK IN LOCAL, NATIONAL OR INTERNATIONAL ARENA

2012- present World Allergy Organisation (WAO) Ask the Expert panel

2012- present The Royal College of Physicians: Research Panel member

2005- present ARIA (Allergic Rhinitis and its Impact on Asthma) Guidelines Committee and Executive Committee member

2012-2015 The Royal College of Physicians: Regional specialty advisor for Allergy & Clinical Immunology

Sep 2007-Sep 2010 Asthma UK Research Committee

2006-2009 Specialist Advisory Committee for Immunology and Allergy, Joint Royal Colleges of Physicians Training Board (JRCPTB)

2002-2010 British Asthma Guidelines steering group; Member of the non-pharmacological management group

2006-2008 ERS (European Respiratory Society) Taskforce on Management of wheezing disorders in Children

2005-2007 GARD (Global Alliance Against Chronic Respiratory Diseases)

Oct 2005-Jul 2006 National Allergy Advisory Group, Department of Health

2003-2004 The National Asthma Campaign Early Life Task Force

2002-2003 The National Asthma Campaign Consultation on clinical asthma research strategy (CARS)

2001-2002 The National Asthma Campaign Consultation on basic asthma research strategy (BARS)

2000-2002 Member of the European Multidisciplinary Scientific Network on Indoor Environment and Health – EUROEXPO Group

2000-2001 GINA (Global Initiative for Asthma) NHLBI/WHO Workshop – Consultant Contributor

2000-2001 IAACI/WHO Program for Primary Prevention of Allergy and Asthma – Consultant Contributor

2. OFFICES HELD IN A LEARNED SOCIETY OR PROFESSIONAL BODY

Oct 2018-Oct 2021 BSACI Council

Jan 2016-Dec 2018 World Allergy Organisation (WAO): Committee on Scientific and Clinical Issues

Jan 2014-Dec 2018 WAO: Specialty, Training and Clinical Issues Committee

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June 2013- present International Congress of Pediatric Pulmonology, Central Organizing Committee

Jan 2013- present The World Asthma Association (INTERASMA): Pediatric Advisory Board

June 2009-June 2013 President, Asthma Section of the European Academy of Allergy and Clinical Immunology (EAACI)

July 2009-July 2012 Secretary: British Society for Allergy and Clinical Immunology

Jan 2008-Dec 2009 World Allergy Organisation (WAO) Education Council

Jan 2008-Dec 2009 WAO Allergy Diagnosis Special Committee

Jan 2008-Dec 2009 WAO Asthma Special Committee

Jan 2008-Dec 2009 WAO Impact of Climate Change on Allergy Special Committee

Sep 2002-Sep 2004 International Representative to the Environmental and Occupational Disorders Interest Section of the American Academy of Allergy, Asthma and Immunology

August 2000-August 2003 Secretary: British Society for Allergy and Clinical Immunology

July 2000-July 2001 Chairman: European Society of Paediatric Allergy and Clinical Immunology Committee on Environmental Allergens

July 1997-July 2000 Member: BSACI Council

1999-2001 Board Member: Asthma Section of the European Academy of Allergy and Clinical Immunology

1989-1992 Treasurer: Paediatric Section of the College of Physicians of Bosnia and Herzegovina

1991-1992 Member of the Council: Society for Allergy and Clinical Immunology of Bosnia and Herzegovina

MEMBERSHIP OF LEARNED SOCIETIES

Elected Fellow American Academy of Allergy, Asthma and Immunology

Elected Member Collegium Internationale Allergologicum

Founding Member International Society for Children’s Health and the Environment (ISCHE)

Elected Member Association of Physicians of Great Britain and Ireland

Member British Society of Allergy and Clinical Immunology

Member European Academy of Allergology and Clinical Immunology

Member European Respiratory Society

Honorary Member The Allergy Society of South Africa

Honorary Member World Immunopathology Organisation (WIPO)

3. OTHER PUBLIC SERVICE IN A PROFESSIONAL CAPACITY

2012- present Country Ambassador for the United Kingdom, European Centre for Allergy Research Foundation (ECARF)

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2001-2010 The National Asthma Campaign Specialist Advisory Panel

2000-2002 Health Advisory Panel, The British Allergy Foundation

4. LEAD ORGANISATIONAL ROLES IN SUBSTANTIVE NATIONAL OR INTERNATIONAL PROFESSIONAL CONFERENCES

EAACI 2020 Annual Congress, London – Member of the Local Organising Committee

17th International Congress of Pediatric Pulmonology, June 21-24 2018, Naples: Co-Chair, Scientific Program Committee

16th International Congress of Pediatric Pulmonology, 23 - 26 June 2017, Lisbon. Congress President

15th International Congress of Pediatric Pulmonology, June 23-26 2016, Naples: Co-Chair, Scientific Program Committee

14th International Congress of Pediatric Pulmonology, June 25-28 2015, Krakow: Co-Chair, Scientific Program Committee

Second congress of the Croatian Society for Allergy and Clinical Immunology, Zagreb, 22-23 May 2015; Congress co-chair

13th International Congress of Pediatric Pulmonology, June 26-29 2014, Bruges, Belgium: Central Organising Committee; Chair, Abstract and Award Committee

British Society of Allergy and Clinical Immunology (BSACI) Annual Meeting, 28-30 September 2014; Convener: Plenary Session “Severe asthma”

Sixth World Asthma & COPD Forum, London, April 27-30 2013: Co-chairman of the Program Committee

European Academy of Allergy and Clinical Immunology “International Severe Asthma Forum”, October 2012: Meeting Co-chair

BSACI Annual Meeting, Nottingham 2-4 July 2012; Convener: Plenary session “New Frontiers in Molecular Diagnostics”

European Academy of Allergy and Clinical Immunology Summit on Severe Asthma, Athens 10-11 November 2011, Convenor and main organiser

Paediatric Asthma and Allergy Meeting (PAAM), Barcelona, 13-15 October 2011 – Organising Committee

10th International Congress on Pediatric Pulmonology, Versailles, France, 25-27 June 2011 - International Advisory Board

1st European Rhinitis and Asthma Meeting (ERAM) / 8th SERIN (Symposium on Experimental Rhinology and Immunology of the Nose), Brussels 4-6 November 2010; Congress Co-Chair

European Academy of Allergy and Clinical Immunology XXIXI Annual Congress, London 2010 – Member of the Local Organising Committee

4th International Workshop on Indoor Allergens, Aspen, 1-2 September 2007, Co-chair

BSACI Annual Meeting, Loughborough 18-20 July 2005; Organiser: Plenary session – Environmental influences on allergic sensitisation and asthma

BSACI Annual Meeting, Nottingham 30 June-2 July 2003; Organiser: Plenary session – Environmental influences in the development of allergy

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British Society of Immunology (BSI)/BSACI Congress, Harrogate 4-6 December 2002; Organiser: Main Symposium - The early influences on development of the immune response

BSI/BSACI Congress, Harrogate 29 November-3 December 1999; Organiser: Main Symposium - Early life origins and primary prevention of atopic disorders

BSACI Annual Meeting, Nottingham 2-4 August 2000; Organiser: Main Symposium - Allergen Avoidance

D. TEACHING AND LEARNING

1. CURRENT AND PREVIOUS TEACHING DUTIES, UNDERGRADUATE, PROFESSIONAL AND/OR POSTGRADUATE

Departmental teaching duties (Imperial College London) Responsible for the provision of paediatric allergy training for junior medical staff

MSc, PG Cert Allergy

o Module lead, lecturing and examination duties

o Research proposal assignment marking

o Examination Board member

North West

01/07/2008-31/03/2014 Training Programme Director for Allergy, North Western Deanery

Departmental teaching duties (University of Manchester) Responsible for organisation of Project Options for Medical Students at the North West

Lung Centre. Personally supervising approximately 1-2 students/ year.

Responsible for the provision of allergy training for junior medical staff

Tutor for Postgraduate Research in the South Manchester Academic Group 2002-2005

Other teaching (to September 2015)

(1) INTERNAL (University of Manchester) Wythenshawe Representative at the Medical Sciences Graduate Programme

Committee, Medicine/Surgery (Central & South) & St. Mary’s (2001-2003)

M.Sc. Immunology and Immunogenetics Course, Clinical Immunology component

Respiratory Module for Intercalated BSc in Pathology; University of Manchester

MRCPath Course, University of Manchester

Diploma in Respiratory Nursing Course, University of Manchester

Year 1 Special Study Module Supervisor

Project Options Supervisor

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(2) EXTERNAL Imperial College London, MSc in Allergy: 2010-2015

“Basic Clinical Allergy” course – Imperial College School of Medicine, National Heart and Lung Institute, London; 1996 - 2012

BSc in Physiology, Manchester Metropolitan University

(3) INTERNATIONAL EAACI Summer School, Tallinn, Estonia, August 2012 EAACI Winter School, Saariselka, Finland, April 2011 EAACI Summer School, Athens, Greece, June 2010 EAACI Summer School, Sardinia, Italy, September 2010 EAACI Summer School, Mikonos, Greece, June 2009 EAACI Summer School, Porto Heli, Greece, June 2008 International Respiratory School, Dubrovnik, Croatia, October 2007 EAACI Summer School, Crete, July 2007 EAACI Summer School, Khalkidhiki, Greece,June 2006

EAACI/Ga2len Summer School, September 2005, Prague, Czech Republic EAACI/Ga2len Summer School, Dubrovnik, Croatia, September 2003 EAACI Clinical Update Course, Palic, Serbia, June 2002 EAACI Summer School, Rome-Villasimius, Italy, September 2000 European Respiratory Society: European Seminars in Respiratory Medicine, St. Moritz,

Switzerland, July 1999

Publications related to teaching1. Custovic A. The epidemiology of allergic disease. In: Allergy: Respiratory Modular

Training Programme-A training programme for health professionals. Respiratory Education and Teaching Centre, Liverpool, 2003, pp 3-24

2. Custovic A. Avoiding exposure to indoor allergens. In: Allergy: Respiratory Modular Training Programme-A training programme for health professionals. Respiratory Education and Teaching Centre, Liverpool, 2003, pp 49-72

3. Custovic A. Asthma and allergy. In: Allergy: Respiratory Modular Training Programme-A training programme for health professionals. Respiratory Education and Teaching Centre, Liverpool, 2003, pp 3-24

4. Gore RB, Custovic A. Aeroallergen avoidance-What practical advices can we give to patients? CPD Bulletin Immunology and Allergy 2002; 2(2): 40-43

5. Custovic A, Murray CS, Gore RB, Woodcock A. Continuing Medical Education Review: Environmental allergen control. Ann Allergy Asthma Immunol 2002; 88(5): 432-441

2. INNOVATIVE WORK AND DEVELOPMENT OF CURRICULUM I have developed and organised Allergy training days for specialist registrars in

Respiratory medicine in the North West region.

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In collaboration with Dr Andrew Bentley (North Manchester General Hospital) I have developed an Objective-based Allergy Curriculum for Specialist Registrar Training in Allergy in the North West

I have developed a part of the Curriculum for Allergy Training at the Respiratory Education Resource Centre, University Hospital Aintree

Examination responsibilities MPhil, MD and PhD examiner Project Options Examiner SSC Examiner OSCE examiner Marking of 5th year elective reports Marking of the 1st year Special Study Modules

3. RESULTS OF EXTERNAL ASSESSMENTS OF TEACHING ABILITY British Paediatric Respiratory Society Annual Symposium 2016: On a scale of 4

Excellent to Poor 1, my lectures were evaluated as a mean score of 3.9 and 3.7 respectively

The highest scoring Lecturer at the “Basic Clinical Allergy” course – Imperial College School of Medicine for five successive years (over 90% Excellent)

The best feedback at the symposium "HNO auf der Theresie", Munich, April 2008; presentation marked with 1.23 (1=very good; 2=good; 3=ordinary; 4=not good; 5=bad)

Average overall score 4.56 (scale 1-5) for 5 presentations at the American Academy of Allergy and Clinical Immunology Meeting in San Antonio 2005 – Top 10%

Scores 4.82 and 4.7 (scale 1-5) for 2 presentations at the American Academy of Allergy and Clinical Immunology Meeting in San Francisco 2004 – Top 8%

Average score 4.74 (scale 1-5) for 3 presentations at the American Academy of Allergy and Clinical Immunology Meeting in Denver 2003

Average score 4.80 (scale 1-5) for Plenary presentation at the British Thoracic Society Meeting in London 2002 (highest of all scores at the meeting)

Average scores of 4.56-4.80 (scale 1-5) for 3 presentations at the American Academy of Allergy and Clinical Immunology Meeting in New York 2002

The highest scoring Lecturer at ARENA Meetings 2000 and 2001 (AZ Respiratory Education for NHS and Academia) (over 90% Excellent)

The highest scoring Lecturer at the European Academy of Allergy and Clinical Immunology Summer School (Marked 4.86 on 1-5 scale)

The highest scoring Lecturer at M.Sc. Immunology and Immunogenetics Course, Clinical Immunology component

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E. LEADERSHIP AND/OR MANAGEMENT ROLES

Internal

Imperial College01/06/2016-present PICU Redevelopment Steering Group – College

Representative

01/06/2016- present Divisional Research Strategy Committee

Imperial College Healthcare Trust

01/06/2016-present Director, Children’s Clinical Research Facility

University of Manchester01/03/2013- present MRC Health e-Research Centre (HeRC) North Steering Group

01/08/2012-31/03/2014 Centre Lead for Respiratory Medicine in the Institute of Inflammation and Repair

01/09/2008–31/07/2012 Respiratory Research Group Leader, School of Translational Medicine

2005-2007 Research Lead, Academic Division of Medicine and Surgery

2002-2005 Tutor for Postgraduate Research, South Manchester Academic Group

2001-2008 Board of the Institute of Health Sciences, South Manchester University Hospitals Representative

2004-2006 Medical School Clinical Research Degrees Working Party

2004-2006 Medical School Clinical Research Training Committee

2002-2005 Postgraduate Research Training Committee Co-ordinator, South Manchester Clinical Academic Group,

2001-2002 South Manchester Representative; Medical Sciences, Graduate Programme Committee, Medicine/Surgery (Central & South) & St. Mary’s

External

01/09/2018-present UK Research and Innovation Future Leaders Fellowships (UKRI FLF) programme Peer Review College (PRC).

01/02/2017-present Medical Research Council Population and Systems Medicine Board

01/01/2012-31/08/15 Royal College of Physicians (RCP) Regional specialty advisor for Allergy & Clinical Immunology

01/06/2009-14/09/15 Member: North West Allergy and Clinical Immunology Network Strategy Board

01/01/2012-14/09/15 Member: Manchester Respiratory and Allergy Biobank Steering Committee

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01/07/2008-31/03/2014 Training Programme Director for Allergy: North Western Deanery

01/04/2011-31/03/2014 Specialty Lead (Respiratory): NIHR Greater Manchester Comprehensive Local Research Network (GM CLRN)

01/04/2008-31/12/2013 Deputy Director: NIHR Respiratory and Allergy Clinical Research Facility at UHSM / UHSM NIHR Translational Research Facility

01/06/2009-31/05/2013 President: Asthma Section of the European Academy of Allergy and Clinical Immunology (EAACI)

01/07/2009-31/06/2012 Secretary: British Society for Allergy and Clinical Immunology

01/09/2002-31/08/2012 Member: Research & Development Committee, University Hospital of South Manchester NHS Trust

01/09/2002-31/08/2005 International Representative: Environmental and Occupational Disorders Interest Section of the American Academy of Allergy Asthma and Immunology

2001-2002 Member: The Royal College of Physicians Committee on Improvement of Clinical Allergy Services Working Group

2000-2003 Secretary: British Society for Allergy and Clinical Immunology

F. KNOWLEDGE AND TECHNOLOGY TRANSFER

1. Details of how research discovery or innovation has been adopted by industryAcademy of Medical Sciences cites my research in peanut allergy (JACI 2010 & 2011) as an example of research with substantial impact on the health or wealth of the UK. Our work has shown that the IgE response to peanut allergen Ara h 2 s much more predictive of clinical peanut allergy than currently used skin or blood tests based on whole peanut extract. This test has been developed by Phadia AB and has been available in clinical practice since 2010. It has become the new clinical gold standard (>100,000 tests carried out in Europe since 2010).

2. Patents filed and approved

Patents: A novel method for assessing if symptoms in a patient are related to a hypersensitivity to a specific allergen

Patent Cooperation Treaty Application, June 2009; Patent number WO2009070122

European Patent, March 2011; Patent number EP2238457

Priority number(s): SE20070002681 20071130; US20070991323P 20071130

Also published as: JP2011505557 (A); EP2238457 (A1); EP2238457 (A4)

3. CONSULTANCY ACTIVITY IN THE CORPORATE SECTOR

Expert advisor to pharmaceutical companiesCurrent: Novartis, Regeneron, Sanofi, Philips

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Past: Circassia, GlaxoSmithKline (UK and USA), AstraZeneca (UK), Schering-Plough (UK and USA), UCB Pharma (Belgium), ALK-Abello (Denmark), Phadia (Sweden), Pfizer (USA)

4. OTHER APPOINTMENTS/ENGAGEMENTS IN THE BUSINESS COMMUNITY

Coleman Research Group: Executive Forum; Allergenetica

5. EVIDENCE OF THE SUCCESSFUL APPLICATION OF SCHOLARLY ACTIVITY

My contributions have been in areas of genuine unmet clinical need, especially prevention of childhood asthma and food allergy. Of particular merit has been the discovery of a novel diagnostic tests for peanut allergy, which demonstrated how internationally competitive medical science can advance health and welfare and be translated into the benefit for patients.

I was a PI on a key study which demonstrated that early use of inhaled corticosteroids for wheezing in preschool children had no effect on the natural history of asthma or wheeze later in childhood (Lancet 2006). These findings informed and changed national and international guidelines on asthma management. I co-authored a crucial multicentre study funded through a collaborative Asthma UK Grant (Imperial, Manchester and Leicester) which produced reference equations for interpretation of spirometry in childhood (AJRCCM 2009), a marked improvement on the existing paediatric equations.

I was a national co-ordinator for a study of allergen control in asthma using impermeable mattress and bedding covers (showing no effect; NEJM 2002). These results were of great practical significance: as a consequence of these findings, guidelines on the management of asthma and rhinitis had to be re-written.

I presented evidence to the House of Lords on the situation of allergy in the UK. This was quoted in resultant House of Lords Science and Technology Committee sixth report on Allergy (July 2007). MAAS Study on which I am a PI was mentioned in the government report.

As President of the Asthma section of EAACI, I lead the development of the Public Website (www.infoallergy.com) which engages with the public to build confidence in the practice of medical research. I have given numerous presentations to patients and general public (Women’s Institute, Open courses), helping address public concerns about medical practice and research. My long-standing collaborative projects in Africa and countries in transition will contribute to developments and improvements in global health.

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Documents

NAME - Imperial College London Adnan Custo… · Web view1. NAME . Adnan Custovic. DATE OF BIRTH. 25th November 1960. ADDRESS. 4 Spencer Road. London, W3 6DN. G. MC Registration