Mutinda C. Kyama, Ph.D.€¦ · Mutinda C. Kyama, Ph.D. Mutinda C. Kyama, is a lead Biomedical Scientist and Senior Lecturer in the Department of Medical Laboratory Sciences, School

MutindaC.Kyama,Ph.D.

Mutinda C. Kyama, is a lead Biomedical Scientist and Senior Lecturer in the Department of Medical Laboratory

Sciences, School of Biomedical Sciences, College of Health Sciences, Jomo Kenyatta University of Agriculture and

Technology. He has special research interest in studying the pathogenesis of endometriosis, ovarian cancer, breast

cancer, cervical cancerD and stem cell biology and investigate the role of stem cells in the pathophysiology of uterine

benign and malignant tumours. Kyama earned his bachelors degree in Biochemistry from the University of Nairobi,

Kenya in 1998. He graduated with Masters degree in Medical Sciences in 2004 from Katholieke University of Leuven

NKULeuvenO, Belgium. Dr. Kyama in 2005, received the prestigious KULeuvenInterfacultyCouncilforDevelopment

Cooperation grant (IRO Doctoral award in Biomedical Sciences) to carried out his doctoral thesis work at the

Laboratory of ERperimental Gynaecology NDepartment of Obstetrics and Gynaecology, University Hospital

Gasthuisberg, KULeuven, BelgiumO and was awarded a doctor of Biomedical Sciences NMechanisms of Human

DiseaseO on September 2009, under the mentorship of Prof. Dr. Thomas M. DVHooghe. The title of his doctoral thesis

was: Endometriosis: New insight in pathogenesis and search for potential biomarkers. He was a visiting postdoctoral

fellow at the Laboratory of ERperimental Gynaecology NUniversity Hospital Gasthuisberg, KULeuven, BelgiumO in

2011 under the mentorship of Prof. Dr. Thomas M. DVHooghe as a recipient of Interfacultaire Raad voor

Ontwikkelingssamenwerking(IRO)specializationaward offered by KULeuven Interfaculty Council for Development

Cooperation. Dr. Kyama is also a recipient of the WorldEndometriosisSocietyRodolpheMaheauxTravelaward

(2011). This award is given in recognition of outstanding research conducted by individuals who are young

researchers in endometriosis. He has co-authored over 50 scientific articles published in internationally peer-

reviewed Zournals and contributed several book chapters. He has also presented over 50 abstracts at

international[local meetings and has also been invited speaker to international symposium. He has been a member

of European Society of Human Reproduction and Embryology, cum member of the Special Interest Group in

Endometriosis and Endometrium from 2003 to 2009, member of Belgium Society for Reproductive Medicine from

2003 to 2009, and a member of the World Endometriosis Society from 2008 to date. Associate Faculty Member of

the Faculty of 1000 Medicine from 2008 to 2011. Member of the Kenya Society for Immunology from 2011 to date.

Member of the editorial team of the Zournal of Clinical Immunology and Immunopathology, the International

Journal of Reproductive Medicine, the African Journal of Medicine and Health Sciences Research and SM Journal of

Gynecology and Obstetrics. He is adhoc reviewer of several international Zournals including Human Reproduction,

Gynecological Surgery, American Journal of Reproductive Immunology, Molecular Human Reproduction and

Gynecologic ` Obstetric Investigation. He currently has active grants in endometriosis, breast cancer, cervical

cancer and endometrial stem cells.

PUBLICATIONS(InternationalPeer‐ReviewedJournalsandBookchapters)

1. Hussein M, Chai CD, Kyama CM, Mwenda JM, Palmer SS, D’Hooghe TM. c-Jun NH2-terminal Kinase (JNK-)

inhibitor Bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled

randomized study. Fertil Steril Accepted April 2015.

2. DelvouR B, DVHooghe TM, KyamaC, Koskimies P, Hermans RJJ, Dunselman G, Romano A. Inhibition of type 1

17b-hydroRysteroid-dehydrogenase impairs the synthesis of 17b-estradiol in endometriosis lesions. J Clin

Endocrinol Metab. 2014 JanD 99 N1O:27c-84.

3. Kyama CM, Falconer H, Chai D, Mihalyi A, Cuneo S, Mwenda JM, DVHooghe TM. Menstrual endometrial

supernatant may induce stromal endometriosis in baboons. Front Biosci (Schol Ed) 2014 Jan 1D6:1c-28.

4. Sunddvist J, eu H, Vodolagkaia A, Fassbender A, Kyama C, Bokor A, Gemgell-Danielsson K, D'Hooghe TM,

Falconer H. Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide

association studies in a Caucasian population. Hum Reprod. 2013 Mar;28 (3):835-9.

5. Dancet EA, Brinnstrjm M, Brasky K, Chai D, Chan AW, Conn PM, Else J, Falconer H, Fagleabas AT, Farah IO,

Goddeeris BM, Golos TG, Hau J, Hearn JP, Kairiuki TM, KyamaCM, Lebovic DI, Mwenda JM, Ndung'u J, Nyachieo

A, Parker J, Slayden OD, Stouffer RL, Strauss JF, Taylor HS, Vanderpoel S, Westergaard JG, kelinski M, D'Hooghe

TM. The Role of Scientists and Clinicians in Raising Public Support for Animal Research in Reproductive Biology

and Medicine. Biol Reprod. 2013 Feb 7;88 (2):33. doi: 10.1095/biolreprod.112.105908.

c. Falconer H, Sunddvist J, Hong e, Vodolagkaia A, Fassbender A, KyamaCM, Bokor A, DlHooghe TM. Analysis of

common variations in tumor-suppressor genes on chr1p3c among Caucasian women with endometriosis.

Gynecol Oncol. 2012 NovD 127: 398-402.

7. Vodolagkaia A, El-Aalamat Y, Popovic D, Mihalyi A, Bossuyt e, Kyama CM, Fassbender A, Bokor A, Schols D,

Huskens D, Meuleman C, Peeraer K, Tomassetti C, Gevaert O, Waelkens E, Kasran A, De Moor B, D'Hooghe TM.

Evaluation of a panel of 28 biomarkers for a non-invasive diagnosis of endometriosis. Hum Reprod. 2012

SepD27N9O:2c98-711.

8. Fassbender A, Verbeeck N, Bjrnigen D, Kyama CM, Bokor A, Vodolagkaia A, Peeraer K, Tomassetti C,

Meuleman C, Gevaert O, Van de Plas R, OZeda F, De Moor B, Moreau Y, Waelkens E, D'Hooghe TM. Combined

mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis.

Hum Reprod. 2012 JulD 27N7O:2020-9.

9. De Graaff AA, DelvouR B, DVHooghe T, KyamaC, Dunselman G, Romano A. Paired-BoR gene 2 downregulation in

endometriosis correlates with low epidermal growth factor receptor level. Hum Reprod. 2012 JunD27NcO:1c7c-

84.

10. Fassbender A, Waelkens E, Verbeeck N, Kyama CM, Bokor A, Vodolagkaia A, Van de Plas R, Meuleman C,

Peeraer K, Tomassetti C, Gevaert O, OZeda F, De Moor B, DVHooghe TM. Proteomics Analysis of Plasma for Early

Diagnosis of Endometriosis.Obstet Gynecol. 2012D 119: 27c - 285.

11. Vodolagkaia A, Bossuyt e, Fassbender A, KyamaCM, Meuleman C, Peeraer K, Tomassetti C, D'Hooghe TM. A

high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in

endometriosis.Reprod Biol Endocrinol. 2011, Aug 9D 9 N1O:113.

12. Fassbender A, Overbergh L, Verdrengh E, Kyama CM, Vodolagakaia A, Bokor A, Meuleman C, Peeraer K,

Tomassetti C, Waelkens E, Mathieu C, DVHooghe TM. How can macroscopically normal peritoneum contribute

to the pathogenesis of endometriosisn Fertil Steril. 2011 SepD 96 N3O: c97 - 9.

13. Sunddvist J, Falconer H, Seddighgadeh M, Vodolagkaia A, Fassbender A, KyamaCM, Bokor A, Stephansson O,

Padyukov L, Gemgell-Danielsson K, DlHooghe MT. Ovarian cancer-associated polymorphisms in the BNC2 gene

among women with endometriosis. Hum Reprod. 2011D 26N8O: 2253-7.

14. Kyama CM, Mihalyi A, Gevaert O, Waelkens E, Van de Plas R, Meuleman C, DVHooghe TM. Evaluation of

endometrial biomarkers for semi-invasive diagnosis of endometriosis. Fertil Steril. 2011D Mar 15D 95N4O:1338-

1343.

15. Sunddvist J, Falconer H, Seddighgadeh M, Vodolagkaia A, Fassbender A, Kyama C, Bokor A, Stephansson O,

Padyukov L, Gemgell-Danielsson K, DlHooghe TM..Endometriosis and autoimmune disease: Association of

susceptibility to moderate[severe endometriosis with CCL21 and HLA-DRB1. Fertil Steril. 2011D 95 N1O:437-40.

1c. Fassbender A, Simsa P, KyamaCM, Waelkens E, Mihalyi A, Meuleman C, Gevaert O, Van de Plas R, De Moor B,

DVHooghe TM. TRIgol treatment of secretory phase endometrium allows combined proteomic and mRNA

microarray analysis of the same sample in women with and without endometriosis. Reprod Biol Endocrinol.

2010 Oct 21D 8N1O:123.

17. Dassen H, Punyadeera C, DelvouR B, Schulkens I, Marchetti C, Kamps R, Klomp J, DiZcks F, de GoeiZ A, DVHooghe

TM, KyamaC, Ederveen A, Dunselman G, Groothuis P, Romano A. Olfactomedin-4 regulation by estrogen in the

human endometrium reduires epidermal growth factor signalling. Am J Pathol. 2010D 177N5O: 2495-508.

18. Simsa P, Mihalyi A, Schoeters G, Koppen G, KyamaCM, Den Hond EM, Foljp C, DVHooghe TM. In a case-control

study increased eRposure to dioRin-like compounds is associated with endometriosis in women. Reprod

BioMed Online 2010D 20: c81 - c88.

19. Mihalyi A, Gevaert G, KyamaCM, Simsa P,Pochet N, Meuleman C, Billen J, Blanckaert N, Vodolagkaia A, Fulop

V, DVHooghe TM. Non-invasive diagnosis of endometriosis based on a combined analysis of siR plasma

biomarkers. Hum Reprod .2010D 25: c54-c4.

20. KyamaCM.Endometriosis: New insight in pathogenesis and search for potential biomarkers. Leuven University

Press. Thesis Book 2009.

21. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Tomassetti C, Peeraer K, Meuleman C,

DVHooghe TM. Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis.

Front in Biosci. 2009D 1: 444 - 454.

22. Guo SW, Simsa P, KyamaCM, Mihplyi A, Foljp V, Othman EE, D'Hooghe TM. Reassessing the evidence for the

link between dioRin and endometriosis: from molecular biology to clinical epidemiology. Mol Hum Reprod

2009D 15 N10O: c09-24.

23. DVHooghe TM, KyamaCM, Chai D, Fassbender A, Vodolagkaia A, Bokor A, Mwenda JM. Nonhuman primate

models for translational research in endometriosis. Reprod Sci. 2009D 16:152 - c1.

24. Bokor A,KyamaCM, Vercruysse L, Fassbender A, Gevaert O, Vodolagkaia A, De Moor B, DVHooghe TM. Density

of small diameter sensory nerve fibers in endometrium: a semi-invasive diagnostic test for minimal to mild

endometriosis. Hum Reprod. 2009D 24 :3025 - 32.

25. Fassbender A, D'Hooghe T, Mihalyi A, KyamaC, Simsa P, Lessey BA. Plasma C3a-des-Arg levels in women with

and without endometriosis. Am J Reprod Immunol. 2009D 62: 187-95.

2c. DelvouR B, Groothuis P, DVHooghe TM, Kyama C, Dunselman G, Romano A. Increased production of 17b-

estradiol in endometriosis lesions is the result of impaired metabolism. J Clin Endocrinol Metab. 2009D 94:87c -

83.

27. DVHooghe TM, KyamaCM, Mwenda JM. Baboon model for endometriosis. In VandeBerg J, Williams-Blangero S,

Tardif S Eds. The Baboon in Biomedical Research. Springer publishers, 2009D 139 - 15cpp.

28. KyamaCM, Overbergh L, Mihalyi A, Silvio C, Chai D, Debrock S, Mwenda JM, Mathieu C, Nugent N, DVHooghe

TM. Effect of recombinant human Tumor Necrosis Factor alpha NrhTBP-1O and GnRH antagonist on the

eRpression of inflammatory cytokines, adhesion and growth factors in endometrium and endometriosis tissues

from baboons. Fertil Steril. 2008D 89: 1306 - 1313.

29. KyamaCM, Overbergh L, Mihalyi A, Meuleman C, Mwenda JM, Mathieu C, DVHooghe TM. Endometrial and

peritoneal mRNA eRpression of aromatase, cytokines and adhesion factors in women with endometriosis. Fertil

Steril 2008 D 89:301 - 310.

30. KyamaCM, Mihalyi A, Simsa P, Mwenda JM, Meuleman C, DVHooghe TM. Non-steroidal targets in the diagnosis

and treatment of endometriosis. Curr Med Chem. 2008D 15: 100c - 1017.

31. D'Hooghe TM, Nyachieo A, Chai DC, KyamaCM, Spiessens C, Mwenda JM. Reproductive research in non-

human primates at Institute of Primate Research in Nairobi, Kenya NWHO Collaborating CenterO: a platform for

the development of clinical infertility servicesn Hum Reprod 2008D doi: 10.1093[humrep[den1c4.

32. DVHooghe T, Vodolagkaia A, Kyama CM, Mwenda JM, Simoens S. Health economics of endometriosis. In:

Rombauts, Tsaltas, Maher ` Healy Eds. Endometriosis Edition. Blackwell PublishersD 2008: 1 - 1cpp.

33. Kyama CM, Mihalyi A, Chai D, Simsa P, Mwenda JM, DVHooghe TM. Baboon model for the study of

endometriosis. Women's Health 2007D 3: c37 - c4c.

34. Kyama CM, Mwenda JM, Machoki J, Mihalyi A, Simsa P, Chai D, DVHooghe TM. Endometriosis in African

women. Women's Health 2007D 3: c29 - c35.

35. Simsa P, Mihalyi A, Kyama CM, Mwenda JM, Fulop V, DVHooghe TM. Future of endometriosis research.

Women's Health 2007D 3: c47 - c54.

3c. Simsa P, Mihalyi A, Kyama CM, Mwenda JM, Fulop V, DVHooghe TM. New approach in medical therapy:

Selective estrogen receptor modulators NSERMsO and aromatase inhibitors Women's Health 2007D 3: c17 - c28.

37. Kyama CM, TVJampens D, Mihalyi A, Simsa P, Debrock S, Waelkens E, Landuyt B, Fulop V, Mwenda JM,

DVHooghe TM. ProteinChip technology is a useful method in the pathogenesis and diagnosis of endometriosis:

a preliminary study. Fertil Steril. 200cD 86: 203 q 209.

38. KyamaCM, Overbergh L, Debrock S, ValckR D, Vander Perre S, Meuleman C, Mihalyi A, Mathieu C, Mwenda

JM, DVHooghe TM. Increased peritoneal and endometrial gene eRpression of biologically relevant cytokines and

growth factors during menstrual phase in women with endometriosis. Fertil Steril. 200cD 85: 1cc7 q 75.

39. Mihalyi A, Simsa P, Mutinda C. Kyama, Meuleman C, Mwenda JM, DVHooghe TM. Emerging drugs in

endometriosis. Expert Opin Emerg Drugs 200cD 11: 503 q 24.

40. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Peeraer K, Meuleman C, DVHooghe TM.

Endometrial-peritoneal interactions and endometriosis. Guest Editorial. World Endometriosis Society e-JournaI.

200cD 8: 3 - 5.

41. Tomassetti C, Meuleman C, PeRsters A, Mihalyi A, KyamaC, Simsa P, DVHooghe TM. Endometriosis, recurrent

miscarriage and implantation failure: is there an immunological linkn Reprod BioMed Online. 200cD 13: 70c q

712.

42. DVHooghe TM, Mihalyi AM, Simsa P, KyamaC, Peeraer K, De Loecker P, Meeuwis L, Segal L, Meuleman C. Why

We Need a Noninvasive Diagnostic Test for Minimal to Mild Endometriosis with a High Sensitivity. Editorial.

Gynecol Obstet Invest. 200cD 62: 13c - 138.

43. Falconer H, Mwenda JM, Chai DC, Wagner C, Mihalyi A, Simsa P, KyamaCD Cornillie FJ, Bergdvist A, Fried G,

DVHooghe TM. Treatment with Anti-TNF Antibody c5N reduces the eRtent of induced endometriosis in the

baboon. Hum Reprod. 200cD 21: 185c - c2.

44. Mwenda JM, Owuor AR, Kyama CM, Wango EO, MVArimi M, Langat DK. Khat NCatha edulisO up-regulates

testosterone and decreases prolactin and cortisol levels in the baboon. J Ethnopharmacol. 200c; 103:379 q

384.

45. DVHooghe TM, Nugent N, Cuneo S, Chai D, Deer F, Debrock S, KyamaCM, Mihalyi A, Mwenda JM. Recombinant

human TNFRSF1A Nr-hTBP1O inhibits the development of endometriosis in baboons: a prospective, randomiged,

placebo- and drug- controlled study. Biol Reprod 200cD 74: 131 - 13c.

4c. Overbergh L, KyamaCM, Debrock S, ValckR D, Mathieu C, Mwenda JM, DVHooghe TM. Validation of real-time

RT-PCR assays for mRNA duantification in baboons. Cytokine 2005D 31: 454 q 458.

47. Kyama CM, Mwenda JM, DVHooghe TM. Animal studies. In: Sutton, Adamson `Jones Eds. Modern

Management of Endometriosis: Taylor & Francis Medical Books; 2005: 41 q 49pp.

48. Mwenda JM, KyamaCM, Chai DC, Debrock S, DVHooghe TM. The baboon as an appropriate model for study of

multifactorial aspects of human endometriosis. In: S. Wolfe-Coote, Ed. The Laboratory Primate, Part II: Use of

Primate Model in Research. Elsevier books; 2005: 549 q 559pp.

49. Mihalyi A, Kyama CM, Simsa P, Debrock S, Mwenda JM, DVHooghe TM. Role of immunologic factors in the

development of endometriosis: Indications for treatment strategies. Therapy. 2005D 2: c23 q c39.

50. DVHooghe TM, KyamaC, Debrock S, Meuleman C, Mwenda JM. Future directions in endometriosis research.

Ann N Y Acad Sci. 2004D 1034: 31c - 325.

51. Kyama CM, DVHooghe TM, Debrock S, Machoki J, Chai DS, Mwenda JM. The prevalence of endometriosis

among African-American and African-Indigenous women. Gynecol Obstet Invest 2004D 57:40 - 42.

52. DVHooghe TM, Debrock S, KyamaCM, Chai DC, Cuneo S, Hill JA, Mwenda JM. Baboon model for fundamental

and preclinical research in endometriosis. Gynecol Obstet Invest 2004D 57: 43 - 4c.

53. Kyama CM, Debrock S, Mwenda JM, DVHooghe TM. Potential involvement of the immune system in the

development of endometriosis. Reprod Biol Endocrinol. 2003D 1:123 - 127.

54. Mwenda JM, Arimi MM, KyamaMC, Langat DK. Effects of khat NCatha edulisO consumption on reproductive

functions: a review.East Afr Med J. 2003D 80:318 - 323.

55. Mwenda JM, KyamaCM, Arimi MM, Achieng R, Langat DK. The Possible Biological Effect of Khat NCatha edulisO

ERtract On the Reproductive Functions of Male Baboons NPapio anubis). Edited by Gerhard Van Der Horst,

Daniel Franken, Riana Borman, T De Jager ` Silke Dyer, Monduzi Editore 2002; 159 q 1c7pp.

5c. Langat DK, Sichangi MW, Kiio M, Ochiel D, KyamaCM, Otsyula M, Mwenda JM. Evaluation of Non-Radioactive

ELISA Assay Kits for Detection of Retroviral Reverse transcriptase NRTO Activity Associated with Retroviral SIV

and HIV.Afri J Health Sci, 2001D8: 39 - 4c.

ABSTRACTSPRESENTEDATINTERNATIONAL/LOCALSCIENTIFICMEETINGS


Peeraer K, Tomassetti C, Gevaert O, OZeda F, De Moor B, DVHooghe TM. Proteomics analysis of plasma for early

diagnosis of endometriosis. Bestposterprize in thecategory “TranslationalResearch” awarded by ERternal

Strategic Advisory Board, a panel of c eRternal international Zury members, during the Scientific Meeting on

December 4th 2012, KU Leuven , Dept of Development and Regeneration.

2. KyamaCM, Fassbender A, Vodolagkaia A, Mihalyi A, Simsa P, Falconer H, Lebovic DI, Mwenda JM, DVHooghe

TM. Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis. Presented

during the Kenya Immunology Society Workshop, in Nairobi, Kenya, from 24th q 25th May 2012.

3. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DVHooghe TM. Clinical Proteomics: Evaluation of endometrial biomarkers for endometriosis. Presented during

the 4th Annual Meeting of Institute of Tropical Medicine and Infectious Diseases NITROMIDO, in Nairobi, Kenya,

from 24th q 25th May 2012. ITROMID Abstract Book 2012D 15-1c: Oral

4. KyamaCM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DVHooghe TM. Massive ectopic endometrial

necrosis occurs before development of induced endometriosis in baboons. Presented during the 4th Annual

Meeting of Institute of Tropical Medicine and Infectious Diseases NITROMIDO, in Nairobi, Kenya, from 24th q 25th

May 2012. ITROMID Abstract Book 2012D 22-23: Oral

5. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert

N, Vodolagkaia A, Fulop V, D'Hooghe TM. Non-Invasive diagnosis of endometriosis based on a combined

analysis of siR plasma biomarkers. Presented during the 4th Annual Meeting of Institute of Tropical Medicine

and Infectious Diseases NITROMIDO, in Nairobi, Kenya, from 24th q 25th May 2012. ITROMID Abstract Book 2012D

23-24: Oral

c. Kyama CM, Falconer H, Chai D, Mihalyi A, Cuneo S, Mwenda JM, DVHooghe TM. Menstrual endometrial

supernatant may induce stromal endometriosis in baboons. Presented during the 3cth Annual Meeting of the

Kenya Obstetrical and Gynaecological Society (KOGS), at Safari Park Hotel in Nairobi, Kenya, from 15th q 17th

February 2012. KOGS Abstract Book 2012: Oral


Peeraer K, Tomassetti C, Gevaert O, OZeda F, De Moor B, DVHooghe TM. Proteomic Analysis of Plasma for Early

Diagnosis of Endometriosis. Presented during the 3cth Annual Meeting of the Kenya Obstetrical and

Gynaecological Society (KOGS), at Safari Park Hotel in Nairobi, Kenya, from 15th q 17th February 2012. KOGS

Abstract Book 2012: Oral

8. KyamaCM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DVHooghe TM. Massive ectopic endometrial

necrosis occurs before development of induced endometriosis in baboons. Presented during the 11th World

Congress on endometriosis in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book 2011D

38 - 39: FCr5-4 Oral.AwardedRodolpheMaheauxTravelgrant(KyamaCM).

9. Vodolagkaia A, Yesilyurt BT, Fassbender A, KyamaC, Bokor A, Lambrechts D, DVHooghe T. PLGF and HIF1-alpha

polymorphisms are associated with endometriosis in Caucasian women. Presented during the 11th World

Congress on endometriosis (WCE) in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book

2011D 93: P1-90 Poster.

10. Fassbender A, Waelkens E, Verbeeck N, KyamaC, Bokor A, Vodolagkaia A, Meuleman C, OZeda F, De Moor B,

DVHooghe T. Plasma SELDI-TOF-MS proteomic analysis for the diagnosis of ultrasound negative endometriosis.

Presented during the 11th World Congress on endometriosis (WCE) in Montpellier, France from September 4th

to 7th, 2011. WCE Abstract Book 2011D 111: P2-133 Poster.

11. De Graaff AA, DelvouR B, DVHooghe T, KyamaC, Dunselman G, Romano A. Paired-BoR gene 2 downregulation in

endometriosis correlates with low epidermal growth factor receptor level. Presented during the 11th World


2011D 39 - 40: FCr5-4 Oral

12. Fassbender A, Verbeeck N, on behalf of DeMoor B, Nitsch D on behalf of Moreau Y, Kyama CM, Bokor A,

Vodolagkaia A, Meuleman C, OZeda F, Waelkens E, DVHooghe T. Combined mRNA microarray and proteomic

analysis of eutopic endometrium of women with and without endometriosis. Presented during the 11th World


2011D 24: Sr9-4 Oral

13. Vodolagkaia A, El-Aalamat Y, Popovic D, KyamaC, Fassbender A, Bokor A, Meuleman C, Peeraer K, Tomassetti

C, DVHooghe T, De Moor B, Huskens D, Schols D. Panel of plasma biomarkers can predict endometriosis with

high sensitivity in patients with ultrasound negative endometriosis. Presented during the 11th World Congress

on endometriosis (WCE) in Montpellier, France from September 4th to 7th, 2011. WCE Abstract Book 2011D 21:

Sr8-3 Oral

14. Lebovic DI, Yu J, DVHooghe TM, KyamaC, Bird IM, Taylor RN. PPAR-GAMMA receptor ligation reduces eutopic

endometrial nerve fiber density in baboons: A prospective, randomiged, placebo-controlled study. Presented

during the 11th World Congress on endometriosis (WCE) in Montpellier, France from September 4th to 7th,

2011. WCE Abstract Book 2011D 7 - 8: Sr3-2 Oral

15. Fassbender A, Overbergh L, Verdrengh E, Kyama CM, Vodolagakaia A, Bokor A, Meuleman C, Peeraer K,

Tomassetti C, Waelkens E, Mathieu C, DVHooghe TM. How can macroscopically normal peritoneum contribute

to the pathogenesis of endometriosisn Presented during the 27th Annual meeting of European Society of

Human Reproduction and Embryology (ESHRE) in Stockholm, NSwedenO from July 3rd to July cth 2011. Hum

Reprod. 2011D 2c: P255- Poster

1c. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DVHooghe TM. Clinical Proteomics: Evaluation of endometrial biomarkers for endometriosis. Presented during

the University of Nairobi, College of Health Sciences 1st International Scientific Conference, in Nairobi, Kenya,

from 15th q 17th June 2011. Abstract Book 2011D 20-21: Oral

17. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert


analysis of siR plasma biomarkers. Presented during the University of Nairobi, College of Health Sciences 1st

international Scientific Conference, in Nairobi, Kenya, from 15th q 17th June 2011. Abstract Book 2011D 20: Oral

18. Fassbender A, Waelkens E, KyamaC, Bokor A, Vodolagkaia A, Verbeeck N, Van de Plas R, OZeda F, Gevaert O,

Meuleman C, Peeraer K, Tomassetti C, De Moor B, DVHooghe TM.Biomarkers in Plasma or Serum: Pitfalls in

Data Processing. Presented during the 58th Annual Scientific Meeting of the Society for Gynecologic

Investigation, Miami Beach, Florida, USA, March 1c-19, 2011.Poster

19. Kyama CM, Falconer H, Cuneo S, Chai D, Moerman P, Mwenda JM, DVHooghe TM. In vivo endometrial-

peritoneal interactions in the ontogenesis of endometriosis in baboons. Presented during the 35th Annual

Meeting of the Kenya Obstetrical and Gynaecological Society (KOGS), in Nakuru, Kenya, from 1cth q 18th

February 2011. KOGS Abstract Book 2011: Oral

20. Vodolagkaia A, Fassbender A, KyamaCM, Bokor A, ClerinR P, Gevaert O, Schols D, Huskens D, Meuleman C,

Peeraer K, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the

Vereniging voor Fertiliteitsstudie (Society for Fertility StudyO, Leuven, Belgium May 21st, 2010.

21. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Meuleman C, De Moor B, DVHooghe TM.

Biomarkers for endometriosis. Presented during the 18th Institute of Primate Research International Biomedical

Research Conference, in Nairobi, Kenya, from cth q 8th July 2010. Abstract Book 2010D 20-21: Oral

22. DVHooghe TM, Kyama CM, Chai D, Mwenda JM. Endometriosis: Lessons from a primate model. Presented

during the 18th Institute of Primate Research International Biomedical Research Conference, in Nairobi, Kenya,

from cth q 8th July 2010. Abstract Book 2010D 18: Oral

23. van Kaam K, DelvouR B, Romano A, D'Hooghe T, KyamaC, Groothuis P.ERpression of DNA methyltransferases

and methyl-CpG-binding domain proteins in human endometrium and endometriosis. Presented during the

2cth Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Rome, NItalyO from

June 27th to June 30th 2010. Hum Reprod. 2010D 25: i2c-i28: O-0c8- Oral.


Peeraer P, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Presented during the 2cth Annual meeting of European Society of

Human Reproduction and Embryology (ESHRE) in Rome, NItalyO from June 27th to June 30th 2010. Hum Reprod.

2010D 25: i9-i11D O-022- Oral.

25. Fassbender A, Vodolagkaia A, Bossuy eB, KyamaM, Meuleman C, Peeraer K, Tomassetti C, DVHooghe T. Value

of plasma CRP and HSCRP levels as a biomarker for a non-invasive diagnosis of endometriosis. Presented

during the 2cth Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Rome,

NItalyO from June 27th to June 30th 2010. Hum Reprod. 2010D 25: i210-i235. P-244.

2c. Mihalyi A, Gevaert O, KyamaCM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert


analysis of siR plasma biomarkers. Presented during the 34th Annual Meeting of the Kenya Obstetrical and

Gynaecological Society (KOGS), in Nairobi, Kenya, from 17th q 19th February 2010. KOGS Abstract Book 2010D

20-21: Oral


Peeraer K, Tomassetti C, De Moor B, D'Hooghe TM. Evaluation of 28 different plasma biomarkers for potential

non-invasive diagnosis of endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the

Vereniging voor Fertiliteitsstudie NSociety for Fertility StudyO, Leuven, Belgium May 21st, 2010

28. DelvouR B, Groothuis P, DVHooghe TM, KyamaC, Dunselman G, Romano A. The hyper-estrogenic environment

in endometriosis lesions is the result of impaired steroid metabolism. Presented during the 25th Annual

meeting of European Society of Human Reproduction and Embryology (ESHRE) in Amsterdam, NNetherlandsO

from June 28th to July 1st 2009. Hum Reprod. 2009D 24: i10 q i10. O-022- Oral.

29. Fassbender A, DVHooghe TM, Mihalyi A, KyamaC, Simsa P, Lessey B. The relationship between C3a-des-Arg and

endometriosis. Presented during the c4th Annual Meeting of the American Society for Reproductive Medicine

in San Francisco, NCA - USAO from November 8th to 12th 2008. Fertil Steril 2008D 90D S143-S143. Poster

30. Bokor A, KyamaCM, Fassbender A, Vodolagkaia A, D'Hooghe T. Density of small diameter sensory nerve fibres

is endometrium: a semi-invasive diagnosis for minimal to mild endometriosis. IN TRAINING AWARD, Best

ScientificPrizePaperCandidate(BokorA). Presented during the c4th Annual Meeting of the American Society

for Reproductive Medicine in San Francisco, NCA - USAO from November 8th to 12th 2008. Fertil Steril 2008D 90:

S42-S42D O-115-Oral

31. Bokor A, KyamaCM, Fassbender A, Vodolagkaia A, Vercruysse L, DVHooghe TM. sEndometrial Multiple Small

Sensory Nerve Fibers in Minimal and Mild Endometriosist. Presented at the 20th meeting of the Belgian Society

for Reproductive Medicine, Brussels, Belgium, October 3rd 2008. Oral

32. Fassbender A, KyamaCM, Overbergh L, Debrock S, ValckR D, Vander Perre S, Meuleman C, Mihalyi A, Mwenda

JM, Mathieu C, D'Hooghe TM. Aberrant gene eRpression of cytokines in peritoneum and endometrium during

the menstrual phase in women with endometriosis. Presented during the 8th PAX Society meeting in Clermont-

Ferrand NFranceO from September 18th to 20th 2008. Oral

33. DelvouR B, DVHooghe TM, Kyama CM, Dunselman G, Groothuis P. Romano A. The high ratio of 17b-

hydroRysteroid dehydrogenase type 1 versus type 2 in endometriosis leads to a hyper-estrogenic environment

in the ectopic endometrium. Poster presentation at the 18th International Symposium of the Journal of Steroid

Biochemistry & Molecular Biology NSeefeld, Tyrol, Austria q 18-21 September 2008.

34. KyamaCM, Falconer H, Chai D, Mihalyi A Cuneo S, Mwenda JM, DVHooghe TM. Acellular menstrual fluid can

induce endometriosis in baboons. Presented during the 24th Annual meeting of European Society of Human

Reproduction and Embryology (ESHRE) in Barcelona, NSpainO from July cst to 9th 2008. Hum Reprod. 2008D 23:

ic5 - icc. O-1c2 Oral.

35. Fassbender A, DVHooghe T, Mihalyi A, KyamaCM, Simsa P, Lessey B. The relationship between C3a-des-Arg and

endometriosis. Oral presentation at the Dutch-Belgian Scientific Meeting of the Vereniging voor

Fertiliteitsstudie NSociety for Fertility StudyO, Brussel , Belgium on cth June 2008.

3c. KyamaCM, Mihalyi A, Gevaert O, Simsa P, Waelkens E, Van de Plas R, Mwenda JM, Meuleman C, De Moor B,

DVHooghe TM. Proteomics in translational research: an integrated approach in the pathogenesis and diagnosis

of endometriosis. Presented during the 10th World Congress on endometriosis (WCE) in Melbourne, Australia

from March 11th to 14th, 2008. WCE Abstract ` program Book 2008D 51 - 52: Oral

37. Van Kaam K, DelvouR B, KyamaCM, Dunselman G, DVHooghe TM, Groothuis P. DNA methyltrandferase and

methyl binding domain proteins in human endometrium and endometriosis. Presented during the 10th World

Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract ` program

Book 2008D 37 - 38: Oral

38. Mihalyi A, Simsa P, Kyama CM, Meuleman C Billen J, Bossuyt e, DVHooghe TM. Plasma levels of ILuc, ILu8,

TNFua, CA 125, CA 19u9 and CRP in endometriosis: Their true diagnostic potential. Presented during the 10th

World Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract `

program Book 2008D P-371 Poster

39. DVHooghe TM, Simsa P, Mihalyi A, Schoeters G, Koppen G, Kyama CM, Den Hondt E, Fulop V. Increased

eRposure to dioRin is associated with endometriosis in women. Presented during the 10th World Congress on

endometriosis in Melbourne, Australia from March 11th to 14th, 2008. WCE Abstract ` program Book 2008D 38:

Oral

40. Van Kaam K, DelvouR B, Kyama CM, Dunselman G, DVHooghe TM, Groothuis P. Severe downregulation of

several genes in the eutopic endometrium of women with endometriosis is not the result of promoter

methylation. Their true diagnostic potential. Presented during the 10th World Congress on endometriosis in

Melbourne, Australia from March 11th to 14th, 2008.WCE Abstract ` program Book 2008D 120: P-287 Poster

41. Dassen H, Punyadeera C, Kamps R, Dunselman G, Kyama CM, DVHooghe T, Groothuis P, Romano A.

Olfactomedin 4 eRpression in human endometrium and endometriosis. Presented during the 10th World

Congress on endometriosis in Melbourne, Australia from March 11th to 14th, 2008.WCE Abstract ` program

Book 2008D 117: P-271 Poster

42. KyamaCM, Overbergh L, Mihalyi A, Cuneo S, Debrock S, ValckR D, Vander Perre S, Mathieu C, Mwenda JM,

DVHooghe TM. rhTBP-1 treatment effect on mRNA levels of cytokines in baboons with induced endometriosis.

Presented during the 32nd Kenya Obstetrical and Gynaecological annual Scientific meeting at Hotel

Intercontinental, Nairobi-Kenya from February 20th q 22nd, 2008. Oral


DVHooghe TM. Proteomics in translational research: an integrated approach in the pathogenesis and diagnosis

of endometriosis. Presented during the 32nd Kenya Obstetrical and Gynaecological annual Scientific meeting at

Hotel Intercontinental, Nairobi-Kenya from February 20th q 22nd , 2008. Oral

44. DVHooghe TM, KyamaCM, Chai D, Fassbender A, Bokor A, Vodolagkaia A, Mwenda JM. Nonhuman primate

models for translational research in endometriosis. Second Society of Gynecologic Investigation NSGIO

International Summit Meeting. From embryo and endometrium to implantation sThe translational researcht.

SGI Summit on Reproductive Medicine, IVI Valencia and Catedra Santiago Grisolia, Valencia, Spain, November

10th, 2007. Oral


DVHooghe TM. Evaluation of endometrial biomarkers for semi-invasive diagnosis of endometriosis. Presented

during the 23rd Annual meeting of European Society of Human Reproduction and Embryology (ESHRE) in Lyon,

NFranceO from July 1st to 4th 2007. Hum Reprod. 2007D 22: i107. O-2c9 Oral.

4c. Kyama CM, Mihalyi A, Simsa P, Falconer H, Fulop V, Mwenda JM, Peeraer K, Meuleman C, DVHooghe TM.

Endometriosis is a peritoneal disease. Presented during the 7th PAX Society meeting in Leuven, NBelgiumO from

September 28th to 30th 200c. PAX Adhesions. 200cD 1c: L7-4. Oral

47. Kyama CM, Overbergh L, Mihalyi A, Meuleman C, Mwenda JM, Mathieu C, DVHooghe TM. Aberrant mRNA

eRpression of adhesion factors in women with endometriosis. Presented at the 1cth meeting of the Belgium

Society for Reproductive Medicine (BSRM) in De- Montil, Essene, NBelgiumO on October 13th 200c. Oral

presentation.

48. Kyama CM, Overbergh L, Mihalyi A, Mwenda JM, Mathieu C, DVHooghe TM. Aberrant mRNA eRpression of

adhesion factors in women with endometriosis. Presented during the 22nd Annual meeting of European Society

of Human Reproduction and Embryology (ESHRE) in Pradue, NCgech RepublicO from June 18th to 21st 200c. Hum

Reprod. 200cD 21: i177D P- 4c0 Poster.

49. Mihalyi A, Simsa P, KyamaCM, Meuleman C Billen J, Bossuyt e, DVHooghe TM. Plasma levels of IL-c, IL-8, TNF-

v, CA125, CA19-9 and CRP in endometriosis: their true diagnostic potential. Presented during the 53rd Annual

meeting of Society for Gynaecologic Investigation (SGI) in Toronto-Canada from March 21st to 25th 200c. J Soc

Gynecol Investig 200cD 13: Suppl 2.D P-494 Poster

50. Mihalyi A, Kyama CM, Meuleman C, DVHooghe TM. Peritoneal and endometrial mRNA eRpression of

inflammatory cytokines and aromatase in women with and without endometriosis. Presented at the VVOG

NFlemish Society for Obstetrics and GynecologyO Herfstvergadering, October 1st, 2005. Oral

51. KyamaCM, Mihalyi A, Overbergh L, ValckR D, Meuleman C, Mathieu C, Mwenda JM, DVHooghe TM. Peritoneal

and endometrial mRNA eRpression of inflammatory cytokines and CYP19 NaromataseO in women with and

without endometriosis. Presented during the 9th World Congress on endometriosis in Maastricht NThe

NetherlandsO from September 14th to 17th, 2005. Eur J Obstet Gynecol Reprod Biol. 2005D 123: Suppl 1DS15.

O7.4. Oral

52. KyamaCM, Overbergh L, Mihalyi A, Cuneo S, Debrock S, ValckR D, Vander Perre S, Mathieu C, Mwenda JM,

DVHooghe TM. rhTBP-1 treatment effect on mRNA levels of cytokines in baboons with induced endometriosis.

Presented during the 21st Annual meeting of European Society of Human Reproduction and Embryology

(ESHRE) in Copenhagen NDenmarkO from June 19th to 22nd 2005. Hum Reprod. 2005D 20: i177-i178D P-494 Poster

53. KyamaCM, TVJampens D, Vander Perre S, Landuyt B, Mwenda JM, DVHooghe TM. Differential protein profiling

using Ciphergen ProteinChip technology in endometrium, peritoneum and endometriotic lesions from women

with and without endometriosis. Presented during the 20th Annual meeting of European Society for Human

Reproduction and Embryology (ESHRE) in Berlin NGermanyO on June 27 -30 2004.Hum Reprod. 2004D 19: i10-i12.

O-031. Oral presentation.

54. KyamaCM, Overbergh L, Debrock S, ValckR D, Vander Perre S, Mathieu C, Mwenda JM, DVHooghe TM. The

eRpression of mRNA for inflammatory cytokines is increased in the peritoneum from women with

endometriosis during the menstrual phase. Presented during the 20th Annual meeting of European Society for

Human Reproduction and Embryology (ESHRE) in Berlin NGermanyO from June 27th to 30th 2004. Hum Reprod.

2004D19: i1c4-i1cc. P-488. Poster.

55. Kyama CM, DVHooghe TM, Debrock S, Machoki J, Chai DS, Mwenda JM. The prevalence of endometriosis

among African-American and African-Indigenous women. Presented at the 8th Regional meeting of the

International Society for Gynaecological Endoscopy NISGE) from cth to 8th September 2004 at Cape Town-

South Africa. Oral presentation.AwardforthebestScientificcontribution Nbasic science sessionO.

5c. KyamaCM, TVJampens D, Vander Perre S, Landuyt B, Meuleman C, Mwenda JM, DVHooghe TM. CiphergenVs

ProteinChip technology is a feasible and useful method for differential protein profiling in women with and

without endometriosis. Presented at the 12th meeting of the Belgium Society for Reproductive Medicine (BSRMO

at Brussels-Belgium on October 1st 2004. Oral presentation.

57. KyamaCM, Overbergh L, Debrock S, ValckR D, Vander Perre S, Meuleman C, Mathieu C, Mwenda JM, DVHooghe

TM. Peritoneal and endometrial eRpression of mRNA for inflammatory cytokines and growth factors are

aberrantly increased during menstrual phase in women with endometriosis. Presented at the 12th meeting of

the Belgium Society for Reproductive Medicine (BSRM) at Brussels-Belgium on October 1st 2004. Oral

presentation.

58. Mwenda JM, KyamaCM, Arimi MM, Achieng R, Langat DK. The Possible Biological Effect of Khat NCatha edulisO

ERtract On the Reproductive Functions of Male Baboons NPapio anubis). Proceedings of 9th International

Symposium on Spermatology Cape Town, South Africa, October c-11, 2002. Oral

Documents

Mutinda C. Kyama, Ph.D.€¦ · Mutinda C. Kyama, Ph.D. Mutinda C. Kyama, is a lead Biomedical Scientist and Senior Lecturer in the Department of Medical Laboratory Sciences, School