M/s. J.R.Corporation, Lamdapura road, Savli, Vadodara …environmentclearance.nic.in/writereaddata/Online/TOR/03_Sep_2016... · in MT/Month Proposed Quantity in MT ... Ammonia liquor

M/s. J.R.Corporation, Lamdapura road, Savli, Vadodara-391 770

M/s. Jyoti Om Chemical Research Centre Pvt. Ltd., Ankleshwar. 12

ANNEXURE- I Valid CCA Copy









ANNEXURE- II

LIST OF EXISTING & PROPOSED PRODUCTS AND THEIR PRODUCTION

CAPACITY:

Sr.

No.

Name of Products Existing Quantity

in MT/Month

Proposed

Quantity in

MT/Month

Total

Quantity in

MT/Month

EXISTING

1 Cellulose Acetate

Phthalate-I plusep grade

1.5 0 1.5

2 Hydroxypropyl methyl

cellulose phthalate USP

grade(HPMCP)

1.1 0 1.1

3 Crude sodium Acetate(by

production)

8 0 8

PROPSOED

1. Glimipride 0.0 2 2

2. Carvedilol 0.5 0.5

3. Alendronate sodium 2 2

4. Mirtazepin 0.5 0.5

5. Topiranate 1 1

6. Losartan Potassium 1 1

7. Lacidipine 0.5 0.5

8. Granisetron 0.5 0.5

9. Ondensetron 0.5 0.5

10. Naltrexone 0.5 0.5

11. Buprenorphine HCl 0.5 0.5

12. Metoprolol succinate 3 3

13. Colesevelan HCl 0.3 0.3

14. Montelukast sodium 0.5 0.5

15. Desloratidine 0.6 0.6

16. Levocetrizine

dihydrochloride

0.5 0.5

17. Duloxetine HCl 0.5 0.5

18. Parocxitine HCl 0.4 0.4

19. Diclofenac sodium 5 5

20. Zonisamide 0.6 0.6

21. Lacosamide 0.4 0.4

22. Oxcarbazepine 0.6 0.6

23. Aripiprazole 0.3 0.3

24. Paliparidone 0.3 0.3

25. Quetiapine 1 1

26. Rispiridone 0.5 0.5

27. Balasalazide disodium 1.5 1.5

28. Valacyclovir HCl 1 1

29. Cinacalet HCl 0.5 0.5

30. Deferasirox 1 1

31. Epiinephrine 1 1

32. Zolpidem tartrate 0.2 0.2



33. Fesoterodine fumarate 1 1

34. Pramipraxole

Dihydrochloride

1 1

35. Rabeprazole sodium 0.7 0.7

36. Rosuvastatin calcium 1 1

37. Sitagliptin phosphate 1 1

38. Sumatriptan succinate 1 1

39. Tamsulosin HCl 0.3 0.3

40. Dextromethophan Hbr 2 2

41. Captopril 1 1

42. Pioglitazone HCl 0.5 0.5

43. Fexofenadine HCl 3 3

44. Entaxapone 1 1

45. Amoldipine Besylate 2 2

46. Atovaquone 1 1

47. Clinidipine 1 1

48. Desvenlafaxine 1 1

49. Devalproex sodium 1 1

50. Donepzil HCl 0.3 0.3

51. Dronedarone HCl 0.3 0.3

52. Iopamidol & its

derivatives

10 10

53. Nebivolol 1 1

54. Palonosetron HCl 2 2

55. Pantoprazole sodium 1 1

56. Saxagliptin Monohydrate 1 1

57. Tapentadol HCl 1 1

58. Venlafaxine HCl

&derivative

1 1

59. Zoledronic Acid 1.5 1.5

60. Bethanechol chloride 1 1

61. Nadifloxacin 0.5 0.5

62. Paliperidone palmitate 0.5 0.5

63. Pidotimod 2 2

64. Apixaben 1 1

65. Dofetilide 0.5 0.5

66. Ivacaftor 1 1

67. Oxybutynin chloride 2 2

68. Pregabalin 3 3

69. Agomelantine 0.5 0.5

70. Aceelofenac 3 3

71. Atenolol 0.5 0.5

72. Valproic acid 3 3

73. Sodium valproate 5 5

74. Iavomilnacopran 1 1

75. Milnacipran 0.7 0.7

76. Diatrizoic acid 5 5

77. TBEE 1 1



78. R&D products 1 1

Total 0.00 100 102.6



ANNEXURE-IV

LIST OF PROPOSED RAW MATERIALS

Sr.

No.

Name of

Proposed

Product

Name Raw Materials Proposed

Quantity in T/T

Proposed

Quantity in

T/Month

1. Glimipride Propylene Oxide 0.620 1.24

Trimethyl amine 4.433 8.87

HCl 1.648 3.30

Chloroform 1.768 3.54

Triphosgene 1.117 2.23

Ammonia 0.620 1.24

IPA 3.365 6.73

Methanol 2.823 5.65

Activated charcoal 0.011 0.02

Bethanicoal crude 1.111 2.22

Hyflo 0.001 0.002

Total 17.524 35.047

2. Carvedilol Methylene Chloride 6.037 3.018

Hyflo powder 0.064 0.032

MDC for Hyflo bed 0.161 0.080

Methanol 2.682 1.341

Potassium Carbonate

Anhydrous Powder

0.875 0.438

4-Hydroxy-9H-Carbazole

(CVL-4)

1.145 0.573

Epichloro Hydrine 1.214 0.607

Ethyl Acetate 12.918 6.459

Ammonia liquor sol 1.199 0.599

sodium Chloride 1.649 0.825

Palladium Carbon 0.077 0.039

Acetic Acid Glacial 0.108 0.054

Ethyl acetate for washing 6.929 3.465

n-Butanol 3.061 1.53

Cyclohexane 0.412 0.206

Approved Cavedilol 0.002 0.001

Eno Acticromos 0.412 0.206

Toluene 5.262 2.631

Catalyst A 0.211 0.106

Total 47.406 23.703

3. Alendronate

sodium

Sulfolane anhydrous 3.172 6.345

Gama amino butyric acid 0.689 1.379

Phosphorous acid crystal 0.827 1.655

Phosphorous trichloride 3.117 6.234

Sodium hydroxide flakes 1.724 3.448

Water for sodium hydroxide

solution 1.724 3.448

Activated carbon 0.0351 0.070

Indigo 1.379 2.759



Total 12.670 25.339

4. Mirtazepin Sulphuric acid LR Grade 5.25 2.625

MRT-6 1.428 0.714

Ethylacetate 24.463 12.23

Liquor ammonia 11.866 5.933

Hexane 21.856 10.929

Methanol 13.56 6.78


Total 78.461 39.231

5. Topiranate Acetone 48.912 48.912

Sulphuric acid( C.P. Grade ) 9.239 9.240

D-Fructose Pyranuse 8.313 8.314

Sodium Hydroxide Lye 19.952 19.952

Activated Carbon 0.118 0.119

Toluene 103.489 103.49

Hexane 36.471 36.471

Isopropyl alcohol 3.729 3.729

Slurry of Activated Carbon

in toluene

0.429 0.430


Ethyl acetate 53.271 53.271

Sulfuryl Chloride 1.725 1.725

Pyridine 1.011 1.011

Ammonia 0.865 0.866

Eno carbon 0.161 0.161

SDS 2.355 2.356


Absolute Alcohol 1.232 1.232

Absolute alcohol for

washing

0.273 0.274

Sodium chloride solution in

purified water

24.247 24.248

Sodium Hydroxide Solution

in Purified water

0.103 0.103

Total 340.180 340.180

6. Losartan

Potassium

Dimethyl Acetamide 4.387 4.387

BCFI (2-Butyl-4 chloro-5-

formyl Imidazole)

0.974 0.974

BMCB (4-Bromo Methyl 2-

Cyanobipyenyl)

1.433 1.433

Potassium Carbonate

Anhydrous

0.926 0.231


Sodium Boro hydride 0.069 0.017


Ethyl Acetate for washing 0.436 0.109

Toluene 15.564 3.891

Triethyl amine 2.746 0.686



Hydrochloride

Sodium Azide 1.053 0.26

Sodium Hydroxide

Solution

3.370 0.842

Sodium Hydroxide flakes 0.842 0.210

Methylene Chloride 16.779 4.194

Sodium Nitrite 0.969 0.242

Hydrochloric Acid sol 3.258 0.814

Potassium Hydroxide flakes 0.252 0.063

Purified Water for

Potassium Hydroxide

solution

3.123 0.780


Prurified water for carbon

slury

0.168 0.042

Hydrochloric Acid

(sulphate free) sol

0.561 0.140

Hexane 2.112 0.528

Isopropyl Alcohol 21.23 5.309

Isopropyl Alcohol for SF

Washing

2.671 0.667

Isopropyl Alcohol for

washing

0.601 0.150

Potassium Hydroxide

Pellets

0.184 0.046

Total 99.478 29.966

7. Lacidipine Methylene Dichloride

(MDC)

218.33 109.16

O- Phthalaldehyde 1.466 0.733

t-Butyl Triphenyl

Phosphoranylidine Acetate

(LCD-3)

4 2.000



Ethyl Acetate (for washing) 0.583 0.29

Cyclohexane (for washing) 5.666 2.833

Trifluoro Acetic Acid 2.266 1.133

Ethyl –3- amino Crotonate 3.666 1.833

Isopropyl Alcohol (IPA) 24 12.000


Isopropyl Alcohol (IPA)

for washing

1.333 0.666

Total 267.900 133.950

8. Granisetron 1-methylindazole-3-

carboxylic acid 0.60 0.297

Thionyl chloride 1.26 0.631

Dimethylformamide 0.02 0.008

n-Hexane 5.72 2.858



MDC 27.16 13.581

Endo-9-methyl-9-

azabicyclo[3,3,1]-nonan-3-

amine 0.55 0.273


Sodium bicarbonate 0.71 0.357


IPA 2.10 1.050

HCl 0.49 0.245


Ethanol 10.11 5.056

Total 58.566 29.283

9. Ondensetron Acetone 46.705 3.877

Potassium Carbonate

Anhydrous (Powder )

11.402 0.946

1,2,3,4- Tetrahydro-4H-

Carbazole-4-one

3.040 0.252

Purified Water + Acetone 45.977 3.816

Dimethyl Sulphate 6.141 0.510

Methanol 34.399 2.855

Methanol for washing 7.283 0.605


Para Formaldehyde 1.783 0.148

Dimethylamine

Hydrochloride

4.905 0.407

Sulphate free HCl 1.664 0.138

2- Methyl Imidazole 4.518 0.375

Acetone for washing 8.348 0.693

Methanolic hydrochloride 6.659 0.553

Slurry of Eno Acticromos in

Purified water

3.977 0.330

Liquor Ammonia 4.281 0.355

Total 213.494 17.720

10. Naltrexone Methane Sulphonic Acid 59.541 2.977

DL-Metheionite 4.580 0.229

Naltraxone Stage-1&2 6.106 0.305

Methanol 96.610 4.831

DM Water 61.068 3.053

Liq.Ammonia 143.763 7.188

Chloroforn 587.004 29.350

MDC 115.118 5.756


Toluene 59.091 2.955

Acetic Anhydride 5.610 0.281

Monochlorobenzene 51.744 2.587

Lithium Carbonate 3.793 0.190

Sodium Iodide 3.374 0.169

Ethyl chloroformate 51.325 2.566




Monochlorobenzene for

Activeted Carbon 1.637 0.082

Hyflosupercel 0.259 0.013

Mono Chloro benzene for

washing 10.381 0.519

Sulphuric Acid 21.40 1.070

Acetic Acid 16.351 0.818

Dimethyl formamide 19.610 0.981

Cyclopropyl Methanol 2.599 0.130

Triethylamine 6.964 0.348

Methane sulfonyl Chloride 3.945 0.197

lithium Bromide 3.114 0.156

ethyl acetate 168.204 8.410

Ethyl Acetate for Carbon

slurry 2.787 0.139

Ethyl Acetate for washing 9.291 0.465

Cyclohexane for washing 7.709 0.385

acetone for washing 1.373 0.069

Acetone 8.307 0.415

Activated Charcoal 0.276 0.014


Naltrexone Hydrochloride

Stage-Final 0.029 0.001

Total 1586.122 793.061

11. Buprenorphin

e HCl

Cyclopropyl methanol 1.669 0.834



Methane sulphonyl chloride 5.871 2.935

Lithium bromide 2.040 1.020

Buprenorphine-4 2.029 1.014

Toluene 50.658 25.329

Sodium chloride 6.295 3.148

Eno acticromos 0.195 0.098

Methanol 22.218 11.109

Dimethyl sulfoxide 6.108 3.054

Thiophenol 2.559 1.279

Potassium ter-butoxide 3.022 1.511

Anhydrous citric acid 9.323 4.661

Hydrogen peroxide 0.745 0.372

Citric acid 1.240 0.620

Liquor Ammonia 13.209 6.605



Acetone 5.644 2.822

Acetone For washing 1.880 0.940

Hydrochloric acid L R

Grade

0.420 0.210



Total 205.609 5.140

12. Metoprolol

succinate


Hyflo 0.0057 0.017

Metoprolo stage-1 1.159 3.478

Act. Carbon+ IPA (0.8+3.9) 0.136 0.408

Isopropyl alcohol (wash) 1.162 3.486

Total 11.110 0.047

13. Colesevelan

HCl


Sevelamer free base 0.438 0.131

6-(bromohexyl)

trimethylammoinum

bromide 0.438 0.131

1-Bromodecance 0.285 0.085

NaOH+water(13.3+16.7) 0.263 0.078

NaCl+water(62.5+416.7) 12.610 3.783

Hydrochloric acid 1.135 0.340



Total 26.358 0.111

14. Montelukast

sodium

Methanol 15.500 7.750

Cyclohexylamine 0.855 0.428

Acetic acid 0.768 0.384

Sodium cyano boro hydride 1.085 0.542

Sodium hydroxide flakes+

purified water 9.516 4.758

Methylene chloride 24.425 12.212

Charged MDC 2.225 1.112

Toluene 105.735 52.867

Mercepto methyl

cyclopropyl acetic acid 1.25 0.625

Para toluene sulfonic acid 0.0817 0.040

Sodium bi carbonate

solution in water 3.187 1.593

Toluene for flush 0.270 0.135

Diol(pure) 2.901 1.459

Diisopropyl ethyl amine 0.878 0.439

Solution of methylene

chloride+mesyl cloride 4.480 2.240

Mesylated derivative of diol 0.062 0.031

Acetonitrile 6.792 3.396

Acetonitrile for washing 18.096 9.048

N-Heptane for washing 24.42 12.210

Tetra hydro furan 46.534 23.267

Triton-b 5.030 2.515



Dl-Tartric acid 2.084 1.042

Cyclo Heptanone 0.966 0.483



Tetra hydro furan for

washing 11.607 5.803


Ammonium acetate 8.705 4.352

Acetic acid glacial 0.791 0.395

Toluene for washing 6.304 3.152


5% ferrus sulfate solution in

water 25.027 12.513

N-heptane 71.310 35.655

Triphenylphosphine 0.067 0.033

Acetic acid solution in

purified water 1.618 0.809

Methanolic sodium

hydroxide solution 1.900 0.950

Eno charcol 0.175 0.087


Total 540.78 0.9193

15. Desloratidine Sulphuric acid 1.774 1.064

Ioratidine 1.282 0.769

Ammonia liqour 3.743 2.246


Toluene 17.096 10.257


Methane 0.405 0.243

Total 4.026 72.459

16. Levocetrizine

dihydrochlori

Dimethyl Formamide 3.634 1.817

R-1-1[(4-

chlorophenyl)phenyl

methyl]piperazine

1.923 0.961

2-Chloro ethoxy Acetamide 1.388 0.694

Potassium Carbonate

Anydrous

2.317 1.158

Potassium Iodide 0.067 0.033


NaCl + Purified water 3.605 1.802


Isopropyl alcohol +

Hydrochloric acid mix.

2.259 1.129

Isopropyl alcohol(For

washing)

6.038 3.019

Ethyl acetate(For washing) 1.721 0.860

Methyl ethyl keton 5.538 2.76


Hyflow + Methylene

chloride

0.380 0.190

Hydrochloric acid (CP) 1.361 0.680

Solution of NaOH 3.461 1.730



Hydrochloric Acid (LR

grade), Sulphate free

0.582 0.291


Acetone (For washing) 1.805 0.902

Acetone 5.423 2.711


Total 109.098 0.185

17. Duloxetine

HCl

Duloxetine HCl, St-III 5.633 2.817


Liq. Ammonia 5.529 2.765

Sodium Chloride 4.199 2.100

Sodium Sulfate 3.254 1.627

L(-)-Di-p-toluoyl tartaric

acid 5.978 2.989

Toluene 17.275 8.638

Diisopropyl Ethylamine 0.174 0.087

Phenyl Chloroformate 0.858 0.429


Hydrochloric acid solution 17.174 8.587

Sodium bicarbonate

solution 4.598 2.299

Dimethyl Sulfoxide 10.023 5.012

Sodium Hydroxide flakes 0.527 0.264

Solution of Acetic Acid in

Water 2.877 1.439


Hexane 6.060 3.030

25% solution of Sodium

Hydroxide flakes 4.598 2.299


Anhydrous Sodium Sulfate 0.459 0.230


Ammonium Chloride 0.231 0.116


Acetone 12.013 6.007

Total 363.09 90.773

18. Parocxitine

HCl


Trans(-) paroxol 1.260 0.504


Para toluene Sulfonyl

chloride

1.512 0.605

Methane Sulfonic acid 0.823 0.329

Toluene 25.602 10.24

Sodium Bicarbonate +

Purified water

18.949 7.57

N,N-Dimethyl Acetamide 4.501 1.80

Sesamol 0.887 0.355

Potassium tertiary butoxide 0.596 0.238



Solution of NaOH +

Purified water

13.06 5.227

Di isopropyl ethyl amine 0.739 0.296

Phenyl Chloroformate 1.482 0.593

CP Hydrochloric acid 0.576 0.230



Isopropyl alcohol(For

Washing)

4.530 1.812

Dimethyl Sulfoxide 1.720 0.688

Potassium Hydroxide

Flakes

2.100 0.840

Eno Acticromos carbon 0.039 0.015

Total 100.882 1.261

19. Diclofenac

sodium

Methanol 3.159 15.797

Sodium Hyroxide flakes 0.404 2.021

1-92,6-dichloriphenyl)-2-

indolinone 1.595 7.978

Charcoal 0.255 1.276


Diclofenac epolamine 1.382 6.914

1-(20Hydroxyethyl)-2-

pyrrolidine 0.563 2.819

Acetone 6.521 32.606


Pphosphorous oxychloride 4.08 2.45

Toluene 2.39 1.43



Ammonia 0.71 0.42



Hyflo 0.02 0.01


Methanol 3.00 1.80

Total 0.015 5.511

20. Lacosamide Sodium hydroxide 1.685 0.674

D-serine 0.819 0.327

Tertbutylammonium

bromide 0.039 0.015

t-butyloxycarbonic

anhydride 2 0.800

NaOH flake+water (4.5+18) 0.737 0.295


HCl+water (24.5+48.3) 2.386 0.954


Sodium sulphate 0.786 0.314

Methylene chloride (wash) 2.163 0.865



N-methylmorpholine 0.944 0.377

Isobutyl chloroformate 1.118 0.447

Benzylamine 5.101 2.040


NaHCO3+water (12+150) 5.31 2.124

Sodium hydroxide flake 0.622 0.249

Tertbutylammonium

bromide 0.039 0.015

Dimethyl sulfate 0.963 0.385

Potassium carbonate 0.537 0.215

Acetic anhydride 0.780 0.312


Ethyl acetate (wash) 0.573 0.229

Total 105.0098 0.4410

21. Oxcarbazepin

e

Oxcarbazepine Stage-3 1.282 0.76

Sodium Cyanate 0.621 0.373


Solution of Sulfuric acid 1.689 1.014

Ammonia Liquor 0.022 0.014

Methanol 10.128 6.077

Methanol ( washing ) 1.620 0.972


Toluene (washing) 0.769 0.462

Toluene 8.923 5.354

Acetic acid (washing) 1.153 0.692

Total 54.518 88.593

22. Aripiprazole Methanol 5.088 1.526

7-Hydroxy-3,4-dihydro-1H-

quinolin-2-one

0.643 0.193


1-Bromo-4-chlorobutane 30.974 9.292

Methanol (washing) 1.016 0.304


Cyclohexane (washing) 1.987 0.59

N,N, Dimethyl Acetamide 4.880 1.464


1-(2,3-Dichlorphenyl)

Piperazine HCL

1.007 0.302

Sodium Iodide 0.769 0.238


Ethyl acetate (washing) 1.554 0.46

Ethanol 34.920 10.476

Dry Aripiprazole crude 1.215 0.364


Ethanol (washing) 2.996 0.8989

Aripiprazole (Pure as seed) 0.001 0.0003

Total 101.219 1.053

23. Paliparidone FBPI.HCl 1.40 0.42





Hyflo 0.40 0.122

CTHMP 1.24 0.37

MDC 28.63 8.59

DIPA 1.63 0.49

DMDC 0.79 0.24

Acetone 5.00 1.50

HCl 1.12 0.34

Na2CO3 3.39 1.02

IPA 1.143 3.43

Total 107.363 35.582

24. Quetiapine Sodium Hydroxide flakes 0.210 0.211

2-Amino diphenyle sulfide 0.707 0.708

Toluene 17.924 17.924

Phenyl chloroformate 0.813 0.814



Polyphosphoric acid 5.663 5.664

Acetone 1.499 1.500


N,N-Dimethyl aniline 0.576 0.576

Phosphorous oxychloride 0.466 0.466

Toluene for extraction 1.189 1.189



Triethanolamine 0.576 0.576

Hydroxy Ethoxyrthyl

Piparazine

0.576 0.576



1N HCl 4.543 4.544




Fumaric acid 0.356 0.357


Total 51.935 0.327

25. Rispiridone Methanol 3.917 1.958

Benzisoxazole intermediate 0.991 0.495

Pyridopyrimidine

intermediate 1.229 0.614

Triethanolamine 3.451 1.725

Sodium Bicarbonate 0.991 0.495







Hyflow+IPA (5+7.8) 0.775 0.387

Total 22.007 0.011

26. Balasalazide

disodium

Methanol 40.974 61.462

Balsalazide-1 2.525 3.787

5% Palladium on charcoal 0.063 0.095


Ethyl acetate for Co-

distillaation

4.520 6.780



Hydrochloroc acid

C.P.grade

1.417 2.126

Sodium nitrite 0.601 0.901

Salicylic acid 1.767 2.651

Potassium hydroxide 1.972 2.959


Dicyclohexyl amine 3.387 5.081

Ethanol 6.276 9.414



Isopropyl alcohol for

washing

3.755 5.632

Total 119.558 0.048

27. Valacyclovir

HCl

Dimethylformamide 136.217 136.217

CBZ-L-valine (N-benzyl

oxo valine)

9.537 9.538

1,3-

Dicyclohexylcarbodiimide

8.873 8.873

Acyclovir 5.696 5.696

4-Dimethylamino pyridine 0.740 0.741

Dimethyl formamide (wash) 62.709 62.709


Di-isopropyl ethylamine 3.265 3.266


Isopropyl alcohol (washing) 22.042 22.043

Molecular sieve 4A 5.455 5.456

5% Palladium on CaCO3 1.636 1.637

Hydrogen gas 0.204 0.205

Methanol 103.562 103.563

L-(+)-tartaric acid 1.778 1.779



Total 561.372 1.684

28. Cinacalet HCl Triethyl phosphite 3.171 1.585


Toluene 68.856 34.42

3-

(Trifluoromethyl)Benzaldeh 2.736 1.368



yde

25%w/w sodium methoxide

solution in methanol 4.068 2.034

Methanol 22.324 11.162

5% Palladium

charcoal(50% wet) 0.054 0.027


Hyflo bed 0.273 0.136

Tetrahydrofuran 9.663 4.831

Sodium borohydride 2.378 1.189



Oxalyl chloride 4.363 2.181

DMSO 5.371 2.68




Sodiummetabisulphite 2.807 1.403

Special denatured spirit 35.441 17.720

R-(+)-1-(i-

napthyl)ethylamine

hydrochloride 0.766 0.383




Methylene chloride for

washing 1.514

Cyclohexane for washing 3.553 0.001

Formic acid 0.498 0.0002

Propionaldehyde derivative 1.013 0.0004

D-(-)-Tartaric Acid 0.553 0.0002

Total 334.250 0.134

29. Deferasirox Toluene 3.627 1.813

Salicylic acid 2.789 1.394



Acetone (wash) 2.186 1.093


4-Hydrazinbenzoic acid 0.732 0.366

Acetic acid (wash) 3.263 1.631


Methanol (wash) 1.652 0.826

Sp. Denature Spirit 28.368 14.184


Sp. Denature Spirit (wash) 3.153 1.576

Total 70.24 0.12

30. Epiinephrine Dimethyl formamide 348.051 348.05

Mono Methylamine 77.92 77.92



3,4-Dihydroxy-2'-

chloroacetophenone(DHCA

)

38.96 38.96

Ortho phosphoricacid 8.441 8.44

10% Pd/C 3.409 3.409

Liq. Ammonia 28.591 28.59

Methanol 68.42 68.426


(1S)-(+)-camphor-10-

sulfonic acid

15.98 15.989


Hyflo 0.935 0.935

L-(+)-Tartaric acid 6.77 6.77


Acetic Acid glacial 0.554 0.554


Total 1387.164 1387.164

31. Zolpidem

tartrate

HCl 15.109 3.022

2-(4-methyl phenyl)-6-

methyl-imidazole[1.2-a]

pyridi 3acetonitrile 1.373 0.274


Potassium hydroxide flakes 1.648 0.32




Pivaloyl chloride 0.743 0.148

Dimethyl amine 1.593 0.318


Ethyl acetate (wash) 2.376 0.475

Methanol 11.620 2.324


Hyflow 0.041 0.008

L-(+) Tartric acid 0.302 0.060


Total 84.7196 16.93

32. Fesoterodine

fumarate


Lithium Aluminium

Hydride

0.190 0.190

R-(-)-4-benzyloxy-3-(3-

Diisopropylamino-1-

phenyl-propyl)-benzoic acid

methyl ester

2.719 2.719

Sodium Sulphate 3.852 3.852

Tetrahydrofuran (For

washing)

8.809 8.809

Hyflow 0.476 0.476

THF (For hyflow bed) 4.190 4.190




Palladium on Charcoal 0.252 0.252

Methanol (For washing) 4.523 4.523

Butylated Hydroxy Toluene

NF

0.002 0.0028

Sodium Borohydride 0.0142 0.014

Acetone 0.038 0.038

Toluene 25.33 25.33

Toluene (For washing) 33.85 33.85

NaCl + Purified water 11.5 11.50


Diisopropyl ethylamine 0.619 0.619

Isobutyl chloride +

Methylene Chloride

18.238 18.238

Solution of Sodium

bicarbonate + Purified water

13.852 13.852

Methyl Ethyl keton 19.42 19.428

Methyl Ethyl keton (For

washing)

6.285 6.285

Fumaric Acid 0.42381 0.423

Fesoterodine Fumarate 1.43 1.430

Total 224.43 224.43

33. Pramipraxole

Hydrochloride


(S)-2,6-Diamino-4,5,6,7-

tetrahydro-benzothiazole

1.919 0.383


Propionic anhydride 1.577 0.315

Ammonia liquor 1.013 0.202

Sodium Borohydride 0.934 0.186

Boron Tri-fluoride Ethyl

ether complex

3.578 0.715

Hydrochloric acid C.P.

Grade

11.909 2.381

Sodium Hydroxide Flakes 7.515 1.503




Eno Activated carbon 0.013 0.002

Hydrochloric acid LR

Grade

2.1521 0.430


Acetonitrile (for washing) 1.538 0.307

Total 237.31 47.465

34. Rabeprazole

sodium


2-Mercapto Benzimidazole 1.172 0.821

Solution of sodium

hydroxide flakes in Purified

water

29.240 20.468



2-chloromethyl-3-methyl-4-

(3-methoxypropoxy)-

pyridine HCL

1.976 1.384

Toluene 17.133 11.993

10 % Sodium Chloride

Solution in Purified water

4.349 3.044

Anhydrous Sodium sulphate 1.713 1.199

Toluene for Washing 3.426 2.399


Sodium hypochlorite 4.878 3.415

Solution of Sodium

Thiosulphate in Purified

Water

9.946 6.963

Solution of Hydrochloric

acid in purified water

10.53 7.374


Methylene Chloride for

Washing

8.202 5.74



Ethyl acetate for Co

distillation

10.170 7.119


Methylene Chloride for

Codistillation

8.002 5.602

Hyflosupercel + MDC 0.921 0.645

Acetone for Co distillation 3.801 2.661

Acetone 9.506 6.654


Solution of Sodium

Chloride in purified water

13.640 9.549

Total 265.113 185.591

35. Rosuvastatin

calcium


Tert butyl-3R-Tert butyl

Dimethyl Silyloxy-6-

dimethoxy phospinyl 5-oxo

hexanoate (TSPH)

22.3 22.30

N-[4-(4-Fluoro-phenyl)-5-

formyl-6-Iso

proylpyrimidin-2-yl]-N-

Methyl methane

Sulfonamide

10 10.00

Potassium t-butoxide 4.52 4.52

Potassium hydrogen

sulphate

58.4 58.40

Methanol 125.85 125.85

Ethyl acetate for Washing 35.8 35.80





Sodium chloride solution 210 210.00

Tetrahydrofuran (Flushing) 4.4 4.40

Diethyl methoxy

borane(50%w/w) solution

in THF

7.2 7.20


Acetic acid glacial 7.88 7.88


Hydrogen peroxide 18 18.00

Sodium sulfite 3 3.00

Anhydrous sodium sulfate 5 5.00

Di-isopropyl ether 72.06 72.06

Toluene (Washing) 8.1 8.10

Absolute alcohol 38.95 38.95

Sodium hydroxide 1.23 1.23


Cyclohexylamine 1.11 1.11

Acetone 90.25 90.25


Hyflo 0.5 0.50

Toluene 41.35 41.35


Calcium chloride 1.075 1.08

Total 1396.165 1396.165

36. Sitagliptin

phosphate

N,N-Dimethylacetamide 3.731 3.731

2,4,5-Trifluorophenyl acetic

acid

1.593 1.593

Meldrums acid 1.434 1.434

4-(Dimethylamino)pyridine 0.039 0.039


Pivaloyl chloride 1.769 1.769


Tertiary Butanol 14.81 14.815

Tertiary Butanol For

washing

1.255 1.255

(R)-(+)-α-

methylbenzenamine

1.428 1.428





Platinum on carbon 5% 0.260 0.260


washing

5.202 5.203

Maleic acid 0.781 0.781

Con. sulphuric acid 1.309 1.309






1-hydroxybenzotriazole 0.113 0.113

3-(trifluoromethyl-5,6,7,8-

tetrahydrow[1,2,3]triazolol[

4,3:a]pyrazine HCl

1.195 1.195

5 % Palladium on charcoal

(50% wet)

0.149 0.149

Special Denatured spirit 11.109 11.109

Special Denatured spirit for

washing

1.662 1.662

Phosphoric Acid 0.395 0.395


Total 129.006 129.006

37. Sumatriptan

succinate

4-Hydrazino N-Methyl

Benzene Methane

Sulfonamide Hydrochloride 1.935 1.935


4- Chlorobutanal diethyl

acetal 1.491 1.491

Methanol 45.66 45.661

Disodium Hydrogen

orthophosphate 0.716 0.716




Ethanol 38.4 38.410


Ethanol for washing 1.527 1.527

Succinic acid 0.48 0.480


Sodium cyanoborohydride 0.593 0.593

Aques formaline 1.435 1.435




washing 0.261 0.261




Total 313.88 313.88

38. Tamsulosin

HCl


Ethoxy phenoxy ethyl

bromide

1.095 0.328

(R)-(-)[2-Aminopropyl]-2-

methoxy benzene

sulfonamide

1.647 0.494







IPA 4.243 1.057

HCl 2.190 0.651

Water+ IPA (7+12.5)

(wash)

5.571 1.671

IPA+ HCl (14+13.6) 1.295 0.38


Total 173.52 51.827

39. Dextromethop

han Hbr

PMPPA 4.49 8.98

CHEA 3.383 6.766

Phosphorus oxy chloride 4.15 8.3

Caustic lye 4.46 8.920

Toluene 23.53 47.06

Mandelic acid 0.55 1.1

Formic acid 0.138 0.277

Sodium methoxide powder 0.034 0.068

Phosphoric acid 14.8 29.6

Phosphorus pentoxide 0.54 1.08

Acetone 4.36 8.72

Hyflow 0.045 0.09


Hydro bromic acid 0.091 0.182

Methanol 2.45 4.9

Total 63.006 126.133

40. Captopril Thioacetic acid 0.41 0.41


Methacrylic acid 0.47 0.47

Methanol 0.24 0.24


N,n, dimethyle aniline 0.25 0.25


Zinc 0.02 0.02


L-proline 0.35 0.35

Total 17.33 17.33

41. Pioglitazone

HCl

Benzylidine 1.8 0.9


Caustic flakes 0.7 0.35

Dimethyle formanide 6.3 3.15

Cobalt chloride 0.018 0.009

Dimethyle glyoxide 0.23 0.115

Sodium borohyride 0.38 0.19

Acetone 2.7 1.35

Ethylene acetate 27 13.5


HCl 0.46 0.23




Total 61.98 30.99

42. Fexofenadine

HCl

Ketone 1.27 3.81

DMF 10.49 31.47

Azacyclanol 1.17 3.51

Potassium bicarbonate 0.85 2.55

Potassium iodide 0.01 0.03


Methanol 19.2 57.6


HCl 3 9

MEK 6.89 20.67

Acetone 13.23 39.69


Hyflow 0.02 0.06

Total 58.57 175.71

43. Entaxapone Methanol 14.057 14.057

3,4-Dihydroxy-5-

Nitrobenzaldehyde

1.146 1.146

Piperidine 0.533 0.533

Benzyl Trimethyl

Ammoinum Hydroxide

0.262 0.262

2-Cyano-N, N-Diethyl

Acetamide

1.051 1.051


Acetic acid (washing) 0.903 0.903


Methanol (Washing) 0.910 0.910

Total 26.719 26.719

44. Amoldipine

besylate

Phthyolol amolidite 1.72 3.44


Hydrazine hydrate 0.6 1.2


IPA 5.68 11.36

Benzene sulfonic acid 0.42 0.84

Charcoal 0.06 0.12

Ethyle acetate 18.63 37.26

Total 49.79 99.58

45. Atovaquone 3-chloro heptoquione 1 1


KOH 1 1

Acetic acid 1.4 1.4

Total 17.62 17.62

46. Clinidipine 2-3-(nitrobenzylidene)

acetic acid

1 1

3-aminocrotonic acid

methyl ester

0.3 0.3

Methanol 8.3 8.3



Total 9.6 9.6

47. Desvenlafaxin

e

Tetra hydro-furan 15.70 15.706

Desvenlafaxine Succinate

Stage-2 1.298 1.298

Magnesium metal turnings 0.410 0.410

Iodine resublimed 0.002 0.002

Solution of Isopropyl

bromide+THF 3.340 3.340

Solution of Cyclo

hexane+THF 1.716 1.716

Ammonium chloride 2.597 2.597


Solultion of NaCl 28.348 28.344


Toluene 46.007 46.006

Hexane 8.558 8.558

Vitride 5.018 5.018

Solution of NaOH 3.257 3.257

IPA 7.088 7.085

Succinic acid 0.404 0.404


5% pd/c 0.057 0.057

Hyflow 0.019 0.019

Acetone 9.045 9.045

Total 166.269 166.269

48. Devalproex

sodium

Valproic acid 12.66 12.666





Total 81.636 81.636

49. Donepzil HCl Methanol 25.244 7.573

N-Benzyl-piperidine-4-

carboxylic acid ethyl ester

3.378 1.013

Sodium hydroxide

solution+ Sodium

Borohydride

6.326 1.897

Solution of hydrochloric

acid in purified water

10.822 3.246




Sodium sulfate 1.830 0.549

Methylene chloride for

washing

15.759 4.727

Oxalyl chloride 1.783 0.535

Solution of DMSO + MDC 8.613 2.583

MDC (For DNP-1 solution 4.308 1.292



prepn.)


Solution of Sodium

bicarbonate in Purified

water

3.785 1.135

Solution of Sodium

Chloride in Purified water

15.07 4.521

5,6-methoxy-1-indanone 1.337 0.401

Sodium Methoxide 1.204 0.361

Eno Acticro mos 0.095 0.02

Hyflo + Methylene chloride 0.830 0.249

Methanol for Co-distillation 3.625 1.087


Oxalic acid 0.348 0.104

Total 256.323 76.882

50. Dronedarone

HCl

1-Bromo 3-chloro propane 12.736 3.820

Di-n-butyl amine 2 0.600

HCl+Water (25+102.5) 2 0.60

Di-isopropyl ether 0.72 0.216

NaOH flake+ Water

(10+100)

0.8 0.24



N-Methyl-N, N,N-Trioctyl

Ammonium chloride

0.038 0.011


Palladium on charcoal 0.076 0.023



Oxalic acid 0.817 0.245

NaOH+water (28.6+143) 2.288 0.686

Hyflow 0.224 0.067

Toluene 7.113 2.134

Mesyl chloride 0.244 0.073

Propane-1,2-diol 0.031 0.009

Acetone 12.15 3.645



1-Bromo 3-chloro propane 12.736 3.820

Di-n-butylamine 2 0.600

HCl+water (25+102.5) 2 0.600

Total 107.645 32.287

51. Iopamidol &

its derivatives

Atipaci 1 10

DMA 3.52 35.2

DMAP 1.53 15.3

Serinol 0.336 3.36

TEA 0.4 4

Acetytic anhydride 1.4 14



TBA 0.72 7.2

Methanol 1.52 15.2

NaOH flakes 0.18 1.8

Conc. HCl 0.07 0.7

IPA 14.64 146.4

APC 0.38 3.8

Total 25.696 256.96

52. Nebivolol Benzopyran acetaldehyde 8.33 0.833

Benzopyran ethanamine 2.77 0.277

Sodium ciano borohydride 0.972 0.097

THF 180.55 18.055




6N HCl 13.88 1.388

2N HCl 5.597 0.559

Di-ethyl ether 5.555 0.556

Total 398.474 39.847

53. Palonosetron

HCl

Pal-amine 1.24 2.48

Toluene 12.31 24.62

Trichloro Methyl

chloroformate 0.65 1.3

BF-3 Etherate 1.54 3.08

2N HCl 1.54 3.08

NaOH 3 6

Ehtanolic HCl 1.45 2.9

IPA 33.5 67

Chalcon 0.01 0.02

Total 55.24 110.48

54. Pantoprazole

Sodium

2-chloro, 2-3dimethoxy

pyridine

1.156 1.15

5-diohiomethoxy

benzimidole

1.109 1.109

NaOH 6.38 6.38


Pentaprazole sulfide 3.75 3.75

DCM 41.5 41.5

TEBA 0.017 0.017

Sodium hypochloride 4.906 4.906

Sodium thiosulfite 2.062 2.062

MDC 4.906 4.906


IPE 16.203 16.203



Total 99.44 99.434

55. Saxagliptin

Monohydrate

Carbonic acid 1 1

IPA 1 1



Conc.HCl 0.25 0.25

DCM 8 8

10% NaOH 0.3 0.3


Total 12.35 12.35

56. Tapentadol

HCl

3-methoxy phenyl 0.01 0.01

D-Methionine 0.0067 0.006

Methano sulfonic acid 0.057 0.057

NaOH solution 0.056 0.056


Charcoal 0.0001 0.0001

HCl 0.001 0.0015

Acetone 0.039 0.039

IPA 0.055 0.055

Total 0.2518 0.2518

57. Venlafaxine

HCl

&derivative

Amino Venlafaxine HCl 10.752 10.752

DCM 70.967 70.967

NaOH 24.73 24.731

Formic Acid 10.215 10.215

Formaldehyde 15.05 15.053

Ethyle Acetate 111.29 111.290

NaHCO3 8.602 8.602


IPA 71.612 71.612

HCl 4.838 4.838

Total 328.378 328.378

58. Zoledronic

Acid

IM acid 0.769 1.153

Phospours acid 0.598 0.897

Phosphours oxychloride 0.672 1.008

Dil. HCl 3.538 5.307


Acetone 13.076 19.615

Total 18.725 28.088

59. Bethanechol

chloride

Propylene oxide 0.620 0.372

Trimethyle amine 4.434 2.660

HCl 1.648 0.98


Triphosgene 1.117 0.670

Ammonia 0.620 0.372


IPA 3.366 2.020

Charcoal 0.011 0.0067

Hyflow 0.001 0.00065

Total 16.16 9.686

60. Nadifloxacin Emme 1.402 0.701

Poly Phosphoric acid 0.798 0.399

Methanol 8.005 4.0029

HCl 3.091 1.545




Acetic anhydride 1.893 0.946

Boric acid 0.263 0.131

DMSO 1.388 0.694


4-Hydroxy piperidine 0.419 0.209



Hyflow 0.001 0.0005


Total 22.322 11.1589

61. Paliperidone

palmitate

Paliperidone 1.120 0.560

MDC 51.44 25.724

Palmitic acid 1.344 0.672

DCC 0.840 0.420

4-DMAP 0.089 0.044

MTBE 18.244 9.122

Methanol 23.904 11.952

MEK 13.17 6.589

Total 110.151 55.083

62. Pidotimod Ethyl-L-Thiazodine-4-

Carboxylate HCl

1.428 2.857


MDC 7.785 15.57

L-Pyroglutamic acid 1.014 2.028

DCC 1.642 3.285


HCl 1.011 2.022


Total 15.193 30.389

63. Apixaben 4-Iodoaniline 2.875 2.875

THF 8.625 8.625

TEA 3.018 3.018

5-Bromo Valeryl chloride 3.133 3.133

Potassium hydroxide 2.587 2.587

MDC 36.438 36.438

HCl solution (2N) 28.75 28.75

Sodium chloride solution 17.25 17.25


IPE 14.66 14.66

Toluene 24.16 24.169

Pcl5 (phosphorous Penta

chloride) 6.261 6.261

Brine solution 15.285 15.285

Morpholine 2.147 2.147

Methoxy Hydrazono

compound 1.267 1.267

4N HCl solution 8.838 8.83



Piperidine-2-one 7.699 7.699

Copper iodide 0.138 0.138

N-n'dimethyl ethylene

diamine 0.098 0.098

Potassium phosphate

tribasic 16.58 16.58

DCM 5.922 5.922

Sodium Thiosulphate 2.744 2.744

Ammonium hydroxide 4.935 4.935

Caustic solution 0.207 0.207

HCl 1.381 1.381

Acetone 5.493 5.493



Ammonia gas 1.174 1.174

Sodium bicarbonate soln. 2.349 2.349

Total 244.965 244.965

64. Dofetilide Nitro amine 1.6 0.8

Chloro nitro phenoxy 1.408 0.704

Potassium bicarbonate 3.696 1.848

Sodium iodide 1.328 0.664

DMAC 7.36 3.68

Acetonitrole 20.0424 10.011

IPA 6.4 3.2

5% Pd C 0.048 0.024

Methanol 24.576 12.288

Hydrogen gas 1 0.5


Hexane 10.4 5.2

Methane sulphonyl chloride 1.173 0.58


HCl 0.624 0.312



Hyflo 0.0624 0.031

Total 98.9032 49.933

65. Ivacaftor Aniline 0.373 0.11

EMME 0.932 0.279

PPA 1.305 0.391


HCl 0.522 0.15

Amino Phenol 0.657 0.197

HATU 1.315 0.394

DIPEA 1.462 0.438

DMF 3.655 1.09

Acetone 10.02 3.00


Hyflo 0.062 0.018



Total 20.469 6.116

66. Oxybutynin

chloride

Propargyl alcohol 0.25 0.50

Diethyl amine 0.4375 0.88

Sulphuric acid 0.23 0.46

Formalin 0.625 1.25

Cupric sulfate solution 0.043 0.087

Sodium chloride 0.5 1

Aq. Ammonia 1.875 3.75

Isopropyl ether 1.812 3.625


Hyflo 0.125 0.25

BDA 0.35 0.7

HCl 3 6

Cyclohexane 3.1 6.2

Total 12.57 25.152

67. Pregabalin Isoveraldehyde 1.2 3.6

Ethyl cyano acetate 1.56 4.68

Di-n-propyle amine 0.101 0.3048

N-Hexane 1.8 5.4

Diethyl malonate 2.12 6.36

Urea 0.86 2.58





R-(+)-(a)-phenyl ethyl

amine 0.82 2.46



Liq. Bromine 0.98 2.94

Hyflow powder 0.012 0.036

Total 32.269 96.8088

68. Agomelantine 2-(7-methoxy-1-napthyl)

Acetonitrile

1.234 0.6171


Isopropyl alcohol HCl 0.91 0.456

2-(7-methoxy-1-

napthyl)ethylamine

hydrochloride

1.234 0.617

Sodium acetate anhydrous 0.518 0.259

Acetic anhydrous 0.62 0.31

Total 4.54 2.2711

69. Aceelofenac Diclofenac sodium 0.975 2.92

T-butychloro acetate 0.461 1.38

Toluene 2.5 7.5


Total 3.941 11.815

70. Atenolol Pera hydroxy phenyl 0.751 0.375



Acetamide

Epichlorohydrin 0.864 0.432


Iso propyl amine 1.052 0.526

HCl 0.413 0.206


Charcoal waste 0.015 0.0075

Total 3.3 1.6485

71. Valproic acid Diethyl dipropyl malonate 1.931 5.795



HCl 4.760 14.28

Total 23.745 71.247

72. Sodium

valproate

Valproic acid 0.953 4.769

Acetone 2.197 10.989

NaOH 0.551 2.75

Total 3.701 18.508

73. Iavomilnacipr

an

Lactone 0.926 0.463

Aluminium trichloride 0.826 0.413

Toluene 53.38 51.22

Diethylamine 0.932 0.466

Thionyl Chloride 0.625 0.312

Potassium phthalimide 1.509 0.754


Ethanolamine 1.871 0.935

HCl 0.603 0.30

Caustic 0.301 0.150

Brine solution 9.05 4.528

Isopropyl acetate 7.091 3.545

IPA HCl 1.312 0.656

Total 85.566 67.312

74. Milnacipran Benzyl cyanide 4.347 1.304

Epichloro hydrine 3.043 0.91

Sodamide 3.478 1.043

THF 23.043 6.913

Toluene 68.21 20.46



NaCl 3.173 0.953

Conc. HCl 18.086 5.426


Potassium phthalamide 4.347 1.304

Dimethyle sulfoxide 11.30 3.391

IPA 2.782 0.834

N-hexane 15.434 4.630





Diethyle amine 1.347 0.404

Sodium sulfate 0.782 0.234

NaCl 1 0.3

Mysole 9.434 2.830

Hydrazine hydrate 0.304 0.091

Dichloro methane 15.782 4.734

Methyl Tertiary butyl ether 2.260 0.678

Total 208.713 61.302

75. Diatrizoic acid 3,5-Dinitro benzoic acid 0.5 2.5

Sodium carbonate 0.355 1.775

Pd/c(5% wet) 0.009 0.045


Iodine 0.92 4.6

Potassium chloride 0.5 2.5

Conc.HCl 0.9 4.5

Chlorine gas 0.255 1.275

Acetic anhydride 2.2 11

Sulfuric acid 0.05 0.25

Sodium carbonate 0.905 4.525

Ammonium chloride 0.7 3.5

Total 7.308 36.54

76. TBEE L-Threonine 1.06 1.06

Dimethxy ethane 18.44 18.44

Sulphuric acid 5.31 5.31

Iso butelene 23.13 23.13

Iso propyle ether 23.13 23.13

Ammonia 9.21 9.21

Total 80.28 80.28

77. R&D products -- -- --

TOTAL 11431.86 7986.237



ANNEXURE-V

LAYOUT PLAN



ANNEXURE-VI

SITE PLAN



ANNEXURE-VII

BRIEF MANUFACTURING PROCESS DESCRIPTION



ANNEXURE-VIII

DETAILS OF TREATMENT SCHEME AND DISPOSAL METHODS

Effluent from the process with high COD and washing will be collected in collection

tank, and then this effluent will be taken for Hydrocavitation process. This treated

effluent will be recycled back.

The process wastewater with low COD, Boiler blow down and cooling tower blow down

will be collected in collection cum equalization tank. , Equalized wastewater will be

neutralized in neutralization tank by adding chemical, and brings pH within permissible

limit.

Flocc agents will be added to water and stirred in primary settling tank and flocc will be

allowed settling in primary settling tank for 1.5 hrs. Suspended solid settle will be

removed on sludge drying bed, clarified wastewater pumped in aeration tank. In aeration

tank primary treated water will be kept for 48 hrs and aerated with activated sludge.

After 48 hrs biologically treated water allow to settle in secondary clarifier for 1 hrs.

Settled biomass recycles to aeration tank. Biologically treated water pass through ACF

and PSF for filtration. This treated effluent will be discharged into CETP of M/s. Enviro

Infrastructure Co. Ltd., Umraya, Vadodara for final treatment. Sludge from sludge

drying bed packed in HDPE bag and stored in separate area and finally dispose to TSDF.

Leachate from the sludge drying bed returns to equalization tank.

EQUIPMENT LIST OF ETP

Sr.No. Name of unit Qty. Size

1. Collection Tank 1 0.61m3

2. Neutralization Tank 1 0.61 m3

3. Primary Settling Tank 1 1.22 m3

4. Secondary Settling Tank 1 1.83 m3

5. Final Collection Tank 1 3.0m3

6. Activated Carbon Filter 1 Ready made from market

for 29 KLD 7. Packed Sand Filter 1



ANNEXURE-IX

ETP FLOW DIAGRAM

EXPECTED CHARACTERISTICS OF WASTEWATER BEFORE &

AFTER TREATEMENT

Sr.No. Parameters Unit ETP inlet ETP outlet

1 pH pH scale 5-7 7-8

2 COD mg/l 5000-7000 1000-2000

3 TDS mg/l 1000-5000 1500-2000

4 TSS mg/l 100-200 100-200

5 Ammonical Nitrogen mg/l 15-30 10-15

Washing

Process w/w

which containing

High COD Boiler blow

down Cooling blow

down

Hydro

Cavitations

process

Collection cum Equalization tank

Treated water

will be

recovered

Neutralization tank

Primary settling tank

Secondary clarifier

Activated carbon filter

Packed sand filter

To CETP of M/s.

Process w/w

which containing

low COD



ANNEXURE-X

DETAILS OF HAZARDOUS WASTE GENERATION & DISPOSAL

Sr.

No.

Type of

Waste

Category Existing

Quantity

Proposed

Quantity

Total

Quantity

Method of

Disposal

1. Residue &

waste

28.1 8

T/Month

180

T/Month

188

T/Month

Collection,

Storage,

Transportation,

Disposal to

TSDF site having

incineration

facility.

2. Spent

Catalyst/

Spent

carbon

28.2 What

ever

generated

12.29

MT/month

12.29

T/Month

Collection,

Storage,

Transportation

and sell to

authorized re-

processors.

3. Spent

Solvent

28.6 0 35

T/month

35

T/month

Collection,

Storage,

Transportation

and sell to

authorized re-

processors.

4. Spent solid 28.2 0 394

T/month

394

T/month

Collection,

Storage,

Transportation

and sell to

authorized re-

processors.

3. Discarded

Containers

33.1 100

Nos./year

500

Nos./year

600

Nos./year

Collection,

Storage,

Transportation,

Disposal to

authorized

recyclers.

4. Crude

Sodium

Acetate

28.4 8

T/Month

0 8

T/month

Collection,

Storage,

Transportation,

Disposal by

incineration.

5. ETP sludge 34.1 0 2-3

t/month

2-3

t/month

Collection,

Storage,

Transportation,

Disposal to

TSDF site for

land filling.



ANNEXURE-XI

DETAILS OF WATER CONSUMPTION, WASTEWATER GENERATION AND

TREATMANT

TABLE 1: DETAILS OF WATER CONSUMPTION

Sr.No. Particulate Existing

water

consumption

in KL/day

Proposed water

consumption in

KL/day

Total water

consumption in

KL/day

1 Domestic 0.5 5 5.5

2 Industrial

Process 0.025 25 25.025

Washing 0 25 25

Cooling 0.5 10 10.5

boiler 0.5 10 10.5

gardening 0 5 5

Total(Industrial) 1.025 75 76.025

Total 1.525 80* 81.525

Note: * Out of 80 KL/day, 29 KL/day will be recycled water and remaining

i.e.51 KL/day will be fresh water.

DETAILS OF WASTE WATER GENERATION

Sr.No. Particulate Existing

Wastewater

generation in

KL/Day

Proposed

wastewater

generation in

KL/day

Total wastewater

generation in

KL/day

1 Domestic 0.35 4 4.35

2 Industrial

Process 0 15 15

washing 0 25 25

Cooling 0 2 2

Boiler 0 2 2

Gardening 0 0 0

Total(Industrial) 0 44* 44

total 0.35 19 48.35

Note: *Out of 44 KL/day, 29 KL/day will be recycled in process, remaining 15 KL/day

will be sent to CETP of M/s. Enviro Infrastructure Co. Ltd., Umraya,

Vadodara.



WATER BALANCE DIAGRAM

Note: All units are in KL/Day.

Total water-80

(Fresh 52 +Recovered 29=80)

Domestic

5.0 Process

25

(25 recycled

water)

Cooling

Tower

10

Gardening

5 (4 recycled

+1 fresh=5)

Septic Tank/Soak

Pit

4.0

Effluent

15.0

Blow down

2.0

TO ETP 44

To CETP 15 KLD

Boiler

10

Blow down

2.0

Washing

25

Effluent

25.0

Recycled water 29KLD



ANNEXURE-XII

DETAILS OF FUEL CONSUMPTION

DETAILS OF PROCESS EMISSION

Sr.No. Stack

Attached To

Stack

Height

(M)

Air

Pollution

Control

Measures

Parameter Permissible

Limit

1 Sulphonation

reactor

10 Scrubber SO2 40 mg/Nm3

2 Chlorination

reactor

10 Scrubber Cl 15

Sr.

No.

Stack

Attached

To

Stack

Height

(M)

Type

of

Fuel

Air

Pollution

Control

Measures

Parameter Permissible

Limit

1. Existing

Boiler- 0.8

T/hr

11 Wood-

1.5 T/day

Cyclone

separator

PM

SO2

NOX

150 mg/ Nm3

100 ppm

50 ppm

2. Proposed

Boiler- 2

TPH

(2 nos.)

30 meter

(Common)

Bio coal Cyclone

separator

and Bag

Filter

PM

150 mg/ Nm3

3. Proposed

Thermopack

2 Lac

Kcal/hr

capacity

Furnace

Oil

--- SO2 100 ppm

4. DG set 50

KVA

2 nos.

9 meter Diesel Adequate

stack

height

PM

SO2

NOX

150 mg/ Nm3

100 ppm

50 ppm



ANNEXURE-XIII

LIST OF HAZARDOUS RAW MATERIAL

Sr.No. Name of hazardous raw material 1. Ammonia

2. Sulfuric acid

3. Ammonium chloride

4. Conc. HCl

5. Nitro Amine

6. Zinc

7. Phosphoric acid

8. Hydrogen gas

9. Acetic acid

10. Acetic anhydride

11. Caustic flakes

12. Iso Propyl Alcohol(IPA)

13. Methanol

14. Sodium Chloride

15. Soda ash



ANNEXURE-XIV

PROPSOED TERMS OF REFERENCE

As per standard TOR of organic manufacturing sector issued by MoEF& CC.

Documents

M/s. J.R.Corporation, Lamdapura road, Savli, Vadodara …environmentclearance.nic.in/writereaddata/Online/TOR/03_Sep_2016... · in MT/Month Proposed Quantity in MT ... Ammonia liquor