Abstracts / Can J Diabetes 38 (2014) S29eS74S70

high sucrose diet). Functional drinks caused significant reduction inbody weight and maximum-lowering effect was observed in studyII and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Like-wise, cholesterol and LDL were substantially reduced by 14.42% and30.43% in study IV and study II, respectively. The serum glucose andinsulin levels were also lowered considerably. It is concluded thatdrinks supplemented with catechins and EGCG are effective againstobesity, hypercholesterolemia and hyperglycemia.

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ACSL5 Genotype Influences the Response of Overweight andObese Women to Weight Loss InterventionABISHANKARI RAJKUMAR*y, PIERRETTE BOLONGO, KRISTI ADAMO,MARY-ELLEN HARPER, REMI RABASA-LHORET, ÉRIC DOUCET,DENIS PRUD’HOMME, FRÉDÉRIQUE TESSONy

Ottawa, ON; Montréal, QC

Cellular fatty acid transport is reported to influence body weightloss following a weight loss intervention. The Acyl-CoA SynthetaseLong Chain 5 (ACSL5) gene, coding for a transmembrane proteininvolved in the conversion of fatty acids into fatty acyl-coA esters,produces long and short ACSL5 isoforms by alternative splicing.Previously, the rs2419621 polymorphism has been shown to in-fluence ACSL5 level of expression in skeletal muscle and to beassociated with weight loss. This functional polymorphism createsa new E-box recognized by transcription factor MyoD, increasingtranscription of the downstream reporter gene. We hypothesizethat Caucasian overweight/obese women carrying the rs2419621rare [T] allele will display healthier body composition parameters,in response to weight loss interventions as compared to wildtypeallele carriers. A secondary analysis was performed using the dataof obese (BMI >30) and overweight (BMI >25) women ages 46e70from the Montréal New Emerging Team (MONET n¼137) study andComplications Associated with Obesity (CAO n¼37) study. Using amultiple linear regression model, statistical associations betweenrs2419621 genotype and changes in body composition indices werestudied. We found that the ACSL5 rs2419621 rare allele was asso-ciated with a decrease in total % fat mass (e2.1585, SE¼1.098,p¼0.0517) and visceral fat (e6.216, SE¼2.886, p¼0.033) and anincrease in % lean mass (2.073, SE¼0.985, p¼0.037) and muscleattenuation (1.170, SE¼0.587, p¼0.048) in response to the weightloss interventions. These results indicate that individuals carryingthe ACSL5 polymorphism rs2419621 [T] allele were more respon-sive to lifestyle interventions in comparison to non-carriers.

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Moving on.with Diabetes: An Example of a ComprehensiveKnowledge Translation Strategy to Support Youth with DiabetesMARGARET DUNBAR*, ELIZABETH CUMMINGS, KIERSTEN PIANOSIHalifax, NS

Transition from pediatric to adult diabetes care, includingmastery of diabetes self-management skills, poses significantchallenges. We estimate 60% of youth successfully transfer by 24months post-referral.

Provincial work aims to address the transition needs of diabetesyouth new to the province, leaving the province, or moving withinthe province to adult care. This transition initiative was guided by aliterature review; a survey of diabetes care providers; an expertworking group; and provider/youth/parent review.

In 2012, the Moving on.with Diabetes resource was launched,as the priority focus, to support the care teams and adolescentsprior to, during and after transfer of care. Flow charts and patient/provider tools address the preparation, transition and integrationphases and clearly delineate the roles/responsibilities of pediatricand adult teams, the adolescent and parent/guardian. Preparationstarts at age 13, continuing to age 18.

Moving on.with Diabetes also includes A Youth in TransitionHandbook and mobile app, released in 2014. These resources pro-mote self-management and encourage ongoing connection to adiabetes team. We are reaching out to 16e18 year-olds to introduceand obtain feedback on the handbook and app. Early online surveyresults of teens and parents indicate that 70% found the handbookvery helpful (5/5) on a Likert scale; 43% found the checklists themost helpful aspects of the handbook. Respondents found the appeasy to use.

This project is an example of a comprehensive program based onpast research and guidelines designed to facilitate the transfer ofknowledge/skills to youth with diabetes.

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The Long-Term Risks of End Stage Renal Disease and MortalityAmong First Nations and Non-First Nations People with Youth-Onset DiabetesROLAND DYCK*, YING JIANG, NATHANIEL OSGOODSaskatoon, SK; Toronto, ON

Objective: To compare the long-term risks of end-stage renaldisease and death among First Nations and non-First Nationspeople with youth-onset diabetes.Methods: Using Saskatchewan Ministry of Health administrativedatabases covering the period 1980e2005, we conducted a retro-spective cohort study of end-stage renal disease and death amongyouth with diabetes diagnosed before age 20. We developed Fineand Gray sub-distribution hazards models and cumulative inci-dence functions for the 2 outcomes by First Nations status andduration of diabetes.Results: Incident cases of youth-onset diabetes were diagnosed in352 First Nations and 2288 non-First Nations people. Mean ages atdiabetes diagnosis were 11.7 and 11.2 years respectively (p¼0.13).Adjusted for sex and age at diabetes diagnosis, the risk of end stagerenal diseasewas 2.59 (95% CIs 1.11e6.04) times higher, and the riskof death 2.64 (95% CIs 1.44e4.87) times higher for First Nationscompared to non-First Nations people. After 25 years, the cumu-lative incidence of end-stage renal disease was 12.3% for First Na-tions people compared to 4.3% in their non-First Nationscounterparts. Corresponding mortality rates were 14.6% and 7.2%respectively.Conclusions: First Nations people with youth-onset diabetesexperience higher long-term risks of end-stage renal disease anddeath than their non-First Nations counterparts. Early identifica-tion of type 2 diabetes and secondary prevention of diabetic ne-phropathy are feasible short-term goals for this high-risk group.More effective primary prevention initiatives and programs todelay diabetes onset are imperative to reverse current trends.

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Predictors of Early Insulin Use in Patients with Type 2 Diabetes:A Cross-Sectional StudyWASEEM ABU-ASHOUR*, WILLIAM K. MIDODZI, LAURIE TWELLS,JOHN-MICHAEL GAMBLEy

St. John’s, NL

Objective: To determine the factors associated with early use ofinsulin following a diagnosis of type 2 diabetes.Methods: In this cross-sectional study, we analyzed data from theCanadian Community Health Survey (CCHS) 2012 conducted byStatistics Canada. Early insulin users were defined as survey re-spondents who started insulin less than 1 year following diagnosisof type 2 diabetes. Descriptive statistics and multivariable logisticregression were used to examine the independent predictors ofearly insulin use. Several potential predictors were included in themultivariable regression model including sociodemographics,