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Chapter 40 HTLV-1 Infection of Humanized NOD/SCID ,/ ȖF íí and BALB/c-Rag2 íí ȖF íí Mouse Models Madeleine Duc Dodon, Julien Villaudy, Louis Gazzolo and Gerold Feuer 6SULQJHU 6FLHQFH%XVLQHVV 0HGLD 1HZ <RUN 4 / < 3ROXHNWRYD HW DO HGV Humanized Mice for HIV Research, '2, B 0 'XF 'RGRQ ā - 9LOODXG\ ā / *D]]ROR /DERUDWRLUH GH %LRORJLH 0ROpFXODLUH GH OD &HOOXOH 8QLWp 0L[WH GH 5HFKHUFKH &HQWUH 1DWLRQDO GH OD 5HFKHUFKH 6FLHQWLILTXH (FROH 1RUPDOH 6XSpULHXUH GH /\RQ /\RQ &HGH[ )UDQFH HPDLO PDGHOHLQHGXFGRGRQ#HQVO\RQIU 0 'XF 'RGRQ ā - 9LOODXG\ ā / *D]]ROR 6)5 806 %LR6FLHQFHV /\RQ*HUODQG/\RQ 6XG 806 /\RQ &HGH[ )UDQFH * )HXHU 'HSDUWPHQW RI 0LFURELRORJ\ DQG ,PPXQRORJ\ 681< 8SVWDWH 0HGLFDO 8QLYHUVLW\ 6\UDFXVH 1< 86$ +XPXULQH 7HFKQRORJLHV $UURZ +LJKZD\ /D9HUQH &$ 86$ Abbreviations $7// $GXOW 7FHOO OHXNHPLDO\PSKRPD +,6 +XPDQ LPPXQH V\VWHP +3+6&V +HPDWRSRLHWLF SURJHQLWRUVKHPDWRSRLHWLF VWHP FHOOV +7/9 +XPDQ 7FHOO OHXNHPLD YLUXV W\SH 763+$0 7URSLFDO VSDVWLF SDUDSDUHVLV+7/9 DVVRFLDWHG P\HORSDWK\ 40.1 Introduction 7KH ILUVW FKDSWHU RI KXPDQ UHWURYLURORJ\ ZDV ZULWWHQ LQ ZLWK WKH LVRODWLRQ RI +7/9 +XPDQ 7O\PSKRWURSLF 9LUXV W\SH WKDW FRQFOXGHG WKH ORQJ VHDUFK RI D UHWURYLUXV HWLRORJLFDOO\ OLQNHG WR D WXPRUDO SURFHVV 7KLV UHWURYLUXV ZDV LGHQWLILHG DV WKH FDXVDWLYH DJHQW RI DGXOW 7FHOO /HXNDHPLDO\PSKRPD $7// DQ DJJUHVVLYH DQG FORQDO O\PSKRSUROLIHUDWLYH GLVRUGHU RI PDWXUH &' 7 FHOOV IRU D UHYLHZ VHH >@ 'XULQJ WKH SDVW WKUHH GHFDGHV QXPHURXV HSLGHPLRORJLFDO DQG FOLQLFDO VWXGLHV

Mouse Models

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Page 1: Mouse Models

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Chapter 40HTLV­1 Infection of Humanized NOD/SCID ,/��ȖFí�í and BALB/c­Rag2í�íȖFí�í Mouse Models

Madeleine Duc Dodon, Julien Villaudy, Louis Gazzolo and Gerold Feuer

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Abbreviations

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40.1   Introduction

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Page 2: Mouse Models

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40.2   Virological Aspects of HTLV­1

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Page 3: Mouse Models

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40.3   In Search of Target Cells at the Initiation  of HTLV­1 Induced­Leukemogenesis

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Page 4: Mouse Models

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Page 5: Mouse Models

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40.4   HTLV­1 Infection of HIS Mouse Models

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Page 6: Mouse Models

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40.5   Conclusions and Perspectives

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Page 8: Mouse Models

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Acknowledgments  7KLV� FRQWULEXWLRQ� ZDV� VXSSRUWHG� LQ� SDUW� E\� ,16(50� � &156�� E\� WKH�(XURSHDQ�8QLRQ�3URMHFW� ³,QIHFWLRQ� DQG�&DQFHU´� �,1&$��XQGHU� WKH�6L[WK�5HVHDUFK�)UDPHZRUN�3URJUDPPH� �JUDQW� QXPEHU�� /6+&�&7�������������� DQG� E\� WKH� )RQGDWLRQ� GH� )UDQFH�� FRPLWp�³/HXFpPLH´��QX5$)�����&&$��WR�0''�DQG�E\�JUDQWV�IURP�WKH�86�1DWLRQDO�,QVWLWXWHV�RI�+HDOWK��&$��������DQG�E\� WKH�(PSLUH�6WDWH�6WHP�&HOO�)XQG� WKURXJK�1HZ�<RUN�6WDWH�'HSDUWPHQW�RI�+HDOWK�&RQWUDFW��1<67(0��&�������DQG��1��*������WR�*�)�

HTLV-1 infected HP/HSC

Sequestration in bonemarrow and thymus

Additionaltransformation

events

Hematopoieticstem cells

HTLV-1

Pro-thymocyte

CD4+ T cells

Adult T cellleukemia/lymphoma

lon

Adult T cell

HTLV-1

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Page 9: Mouse Models

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References

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