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Motifs of Protein StructureMotifs of Protein Structure
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Adapted from “Introduction to Protein Structure” by Branden & Tooze
-helix is a dipole moment.
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Adapted from “Introduction to Protein Structure” by Branden & Tooze
1
3
2
Adapted from “Introduction to Protein Structure” by Branden & Tooze
antiparallel -sheet
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Adapted from “Introduction to Protein Structure” by Branden & Tooze
parallel -sheet
Adapted from “Introduction to Protein Structure” by Branden & Tooze
134 25
1 3 2 4 5
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Loop regions are at the surface of protein molecules
Adapted from “Introduction to Protein Structure” by Branden & Tooze
myoglobin
Adapted from “Introduction to Protein Structure” by Branden & Tooze
myoglobin triosephosphate isomerase
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Topology diagram
aspartatetranscarbamoylase
flavodoxin:redox protein
plastocyanin:electron carrier
Adapted from “Introduction to Protein Structure” by Branden & Tooze
helix-turn-helix motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Calcium-binding motif
Troponin-C: a muscle proteinAdapted from “Introduction to Protein Structure” by Branden & Tooze
Calcium-binding motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
Conformational change of calmodulConformational change of calmodulin upon peptide bindingin upon peptide binding
-hairpin motif
bovine trypsin inhibitor snake venom erabutoxinAdapted from “Introduction to Protein Structure” by Branden & Tooze
staphylococcus nuclease
Greek key motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
-hairpin motif
Greek key motif
?
Adapted from “Introduction to Protein Structure” by Branden & Tooze
motif
right hand left handAdapted from “Introduction to Protein Structure” by Branden & Tooze
Large polypeptide chains fold into several domains
Adapted from “Introduction to Protein Structure” by Branden & Tooze
domains are built from structural motifs
triosephosphate isomeraseAdapted from “Introduction to Protein Structure” by Branden & Tooze
protein structure
domain
motif
secondary structure
primary structure
P53
DNA-binding domain
sheet-turn-helix
-helix & -sheet & turn
linear chain
simple motifs combine to form complex motifs
Adapted from “Introduction to Protein Structure” by Branden & Tooze