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Molecular Engineering for Integrated Product Development
Blair BrettmannMaterials Science and Engineering
About Me: Education
• B.S. in Chemical Engineering the University of Texas at Austin
• M.S. at MIT in Chemical Engineering practice• Intern at GlaxoSmithKline
• Intern at Mawana Sugar Works
• PhD at MIT in Chemical Engineering• Pharmaceutical manufacturing and
formulation thesis
• Research sponsored by Novartis
• Senior Research Engineer, Saint-Gobain (2012-2014)
• Polymer processing, coatings and films
• Specialize in processing and formulation
• Projects in window films, glass fiber mats, fluoropolymer films, architectural coated fabrics, etc.
• Research Project Lead
• IR attenuating automobile window film
• Product on market as of 2016
About Me: Industrial Experience
About Me: Return to Academia
• The University of Chicago Institute for Molecular Engineering• Postdoctoral Researcher
• Molecular level fundamental polymer theory
• The IME• Engineering school centered around
molecular-level science
• Draw from a multidisciplinary background (MSE, ChE, BME, physics, chemistry, biology)
Molecular Engineering for Integrated Product Development
Research Focus: Link molecular to micron scale phenomena to processing and multicomponent complex mixtures to enable rapid product development
Polymer Processing Complex Systems Modular Pharmaceuticals Polymer Physics
Concentration of multivalent ions mol/L10
-710
-610
-510
-4
Bru
sh h
eig
ht
(nm
)
0
20
40
60
80
100
Epsilon multivalent=8, epsilon monovalent=1, g=3
Exprimental results, Ionic strength 0.003Theoretical results
Research Areas of Interest
• Solution Processing• Coating processes
• Electrospinning/spraying
• Formulation
• Characterization• Solution rheology
• Microrheology
• Solid state characterization of films and coatings
Capabilities and Expertise
Nanocellulose for pharmaceutical products
• Graduate Student: Manali Banerjee• RBI Fellow• Nanocellulose as a pharmaceutical excipient
• Processing• Interaction with active pharmaceutical ingredients• Drug delivery and release
Nanocellulose for pharmaceutical products
• Renewable and biocompatible
• Small size with high strength and stiffness and high surface area
• Hydroxyl groups make it highly hydrophilic and introduce partial surface charges
Surface
modifications
NC + modifier
Nanocellulose
Hydrophobic surface
Hydrophilic drugs
Hydrophobic drugs
Nanocellulose solution
Pharmaceuticals
Solution of drug and
nanocellulose
Extrusion or solvent casting Drugs in NC
matrix
Drug particles+
Dip or spray coating
NC coated drugs
Nanocellulose Structure
Processing of polyelectrolyte complexes
• Graduate Student: Sarah Forester
• 3M Fellow
Interfacial Polyelectrolyte Complexation
*Kenis et al., Science, 1999
Complexation under flow
*Wan et al., Adv. Healthcare Mat., 2012
Ideation and discovery
Development and concept
testing
Scale-up to manufacturing
and launch
Vision for Integrated Product Development