Module Specification · 2021. 9. 1. · Module Specification No. Assessment Description Weight % Qual Mark Exam Hours Ass't Group Alt Reass't 001 Examination (Final) 50 1.5 002 Practical

Module Specification

No. Assessment Description Weight % Qual Mark Exam Hours Ass't Group Alt Reass't

001 Examination (Final) 50 1.5002 Practical Reports 35003 Class Test 15

Period: Semester 2Occurence: ACoordinator: Richard BadgeMark Scheme: PGT Module Mark Scheme

Academic Year: 2018/9Module Level: PostgraduateScheme: PGDepartment: Molecular and Cell BiologyCredits: 15

Intended Learning OutcomesOn successful completion of the module, students should be able to:

- Demonstrate an understanding of the foundational knowledge underpinning the relationships between genes, genomes,transcriptomes and proteomes.- Explain their understanding of the nature and execution of genome sequencing projects and their various functionalramifications, e,g, transcriptomics.- Demonstrate knowledge of the application of genomic scale computational analyses in understanding genome function.- Explain their understanding of, and apply gene prediction methods to annotate novel genomic data.- Compare and analyse DNA, RNA, and protein sequences using appropriate algorithms.- Generate phylogenies of related sequences and interpret the molecular evolution of these sequences using statisticalmethods.

Teaching and Learning MethodsLectures, surgeries, directed reading, computer pracitical classes, demonstrations, resource based learning

Assessment Methods

Pre-Requisites

Co-Requisites

Excluded Combinations-

Guided Independent Study: Indicative ActivitiesGuided reading, lecture revision, guided computer activities,computational activities for coursework, preparation ofcoursework reports, preparation for examination, examination

Lectures 20Seminars

Practical Classes & Workshops 30Tutorials

FieldworkProject Supervision

Guided Independent Study 100Demonstration

Supervised time in studio/workshopWork Based Learning

PlacementYear Abroad

Total Module Hours 150

Student Workload (hours)

BS7101 Gene and Genome Analysis

Last Published: 10 September 2021



001 Examination (Final) 50 1.5002 Practical Reports 35003 Class Test 15

Period: Semester 2Occurence: ACoordinator: Peter MoodyMark Scheme: PGT Module Mark Scheme



- Describe the secondary, tertiary and quarternary structure of proteins, the forces determining them and how they aredetermined experimentally- Competently apply molecular visualization to protein structure- Compare sequences and structures of proteins and draw functional and evolutionary conclusions from such comparisons- Discuss the principles, applications and limitations of protein structure prediction and molecular modeling, and apply theseprinciples to problems in protein bioinformatics

Teaching and Learning MethodsLectures, Surgeries, Directed reading, Computer pracitical classes, Demonstrations, Resource based learning

Assessment Methods

Pre-Requisites

Co-Requisites


Guided Independent Study: Indicative ActivitiesGuided reading, lecture revision, guided computer activities,computational activities for coursework, preparation ofcoursework reports, preparation for examination, examination.

Lectures 20Seminars








BS7102 Proteins




001 Examination (Final) 35 1.5002 Programming Assignments 30003 Oral Presentation 15004 Programming Project 20

Period: Semester 2Occurence: ACoordinator: Ralf SchmidMark Scheme: PGT Module Mark Scheme



- Describe the relevance of the UNIX operating system and programming for bioinformatics- Read, understand, modify, write, and debug bioinformatics scripts- Apply UNIX and programming to typical bioinformatics problems- Analyse problems in bioinformatics and develop effective programming strategies to solve them- Demonstrate understanding and apply statistics relevant to bioinformatics- Demonstrate knowledge of selected advanced topics in bioinformatics

Teaching and Learning MethodsLectures, Surgeries, Directed reading, Computer practical classes, Demonstrations, Resource based learning

Assessment Methods

Pre-Requisites

Co-Requisites


Guided Independent Study: Indicative ActivitiesGuided reading, lecture revision, guided computer activities,computational activities for coursework, preparation ofcoursework reports, preparation for test, preparation of oral presentation.

Lectures 28Seminars 20








BS7105 Bioinformatics Programming and Advanced Topics in Bioinformatics




001 Project Report 35003 Assessment of Code, Website and Documentation 30004 Extended essay (Final) 35




- Apply bioinformatics tools in the context of a research project- Pursue their own interests in bioinformatics with confidence- Present their work in written form, and in form of a website- Work effectively as a team member in a multidisciplinary environment- Solve bioinformatics problems effectively

Teaching and Learning MethodsLectures, Surgeries, Directed reading, Computer practical classes, Resource based learning

Assessment Methods

Pre-Requisites

Co-Requisites


Guided Independent Study: Indicative ActivitiesGuided reading, lecture revision, guided computer activities,computational activities for coursework, preparation ofcoursework report, extended essay

Lectures 2Seminars

Practical Classes & Workshops 20Tutorials 2







BS7120 Steered Research Project




001 Supervisor's assessment of performance 35002 Thesis (Final) 55003 Oral presentation 10



Intended Learning OutcomesBy the end of the module students should be able to: Apply bioinformatics tools effectively to their project of choice. Managetheir time effectively. Pursue their own interests in bioinformatics with confidence. Effectively present their work orally and inwritten form. Work more effectively with peers and line managers. Problem solve more effectively.

Teaching and Learning MethodsPrivate study in the context of a working environment.

Assessment MethodsA combination of individual performance, an oral presentation and a mini-thesis.

Pre-Requisites

Co-Requisites


Guided Independent Study: Indicative Activities

LecturesSeminars

Practical Classes & WorkshopsTutorials

FieldworkProject Supervision15-75






BS7130 Independent Research Project




001 Laboratory Report 1 40002 Laboratory Report 2 40003 Examination 1 20 45 3

Period: Semester 1Occurence: ACoordinator:Mark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesDiscuss and apply the theory and practice of key molecular and biochemical techniquesIsolate DNA and RNA from tissues or cultured cellsPlan experiments, prepare reagents accurately and use micropipettes. Perform basic biochemical calculations.Apply the principles of laboratory safety, COSHH regulations, risk assessment and safe handling of toxic reagents.Use a laboratory notebook and communicate scientific information in a written form. Work in a team.

Teaching and Learning MethodsLectures, Laboratory practical classes, Tutorials

Assessment MethodsLaboratory reportsComputer-based examination

Pre-Requisites

Co-Requisites



Lectures 12Seminars








MB7001 Introduction to Molecular Techniques




001 Laboratory Report 50002 Laboratory Report 50



Intended Learning OutcomesExplain and apply the techniques used to assay activation of intracellular signalling pathways.Outline the role of oncogenes in regulating intracellular signalling, cell growth and cell proliferation.Define the principles of light and fluorescence microscopy.Use indirect immunofluorescence and GFP to study the intracellular localization of organelles and proteins.Assay cell proliferation and identify the stages of mitotic cell division.Demonstrate competence in data analysis and interpretation.Write a logically-structured scientific report.Analyse data from research papers.Be able to perform basic cell culture.Use bioinformatic databases to analyse DNA and protein sequences.


Assessment MethodsLaboratory report. Material in this module is also assessed in Module MB7004.

Pre-Requisites

Co-Requisites



Lectures 3Seminars



Guided Independent Study 58Demonstration 8





MB7002 Research Methods in Cell Biology




001 Laboratory Report 50002 Laboratory Report 50



Intended Learning OutcomesOutline the theory and practice of key techniques for assessing altered protein and mRNA expression in tumour samples.Analyse the migratory and adhesive properties of normal and transformed cells.Identify how angiogenic growth factors and inhibitors can modulate the behaviour of endothelial cells in 3D cultures and CAMassays.Analyse data from research papers.Work as a team to produce and present experimental data. Perform basic statistical test on experimental data.


Assessment MethodsLaboratory reportsMaterial in this module is also assessed in Module MB7004.

Pre-Requisites

Co-Requisites



Lectures 5Seminars








MB7003 Research Methods in Cancer Biology




001 Essay 40002 Examination 1 30 45 3003 Examination 2 30 45 3



Intended Learning OutcomesOutline the molecular and cellular basis of cancer cells.Describe how signalling pathways are de-regulated in cancer cells.Discuss how oncogenes and tumour suppressor genes operate within a cell.Describe the key molecular changes that take place during the progression of a cell from normal to malignancy, with theability to quote specific examples of human tumour progression.Define how anticancer targets are identified and drugs developed.Outline the principles of cancer diagnosis and prevention.Interrogate databases.Write a structured essay.Analyse and interpret experimental data

Teaching and Learning MethodsLectures, Tutorials, Directed learning

Assessment MethodsEssayShort-answer examinationProblem-based examination

Pre-Requisites

Co-Requisites



Lectures 40Seminars

Practical Classes & WorkshopsTutorials 10







MB7004 Advanced Topics in Cancer Biology




001 Lab performance (final) 35002 15,000 word dissertation (final) 55003 Project presentation 10

Period: Semester 2Occurence: A18Coordinator:Mark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesDemonstrate experience of a placement in a research laboratory.Perform background research relevant to a research project.Design and execute experiments.Interpret and analyse data.Prepare and deliver an appropriate oral presentation of the data.Write a structured scientific report.

Teaching and Learning MethodsProject supervision, Directed reading, Supervised laboratory work, Independent research, Writing and presentation skills

Assessment MethodsLaboratory notebooks, Competency-based assessment, Dissertation, Seminar presentation

Pre-Requisites

Co-Requisites



LecturesSeminars



Guided Independent StudyDemonstration



Total Module Hours


MB7006 Masters Research Project




001 Dissertation 100

Period: Academic YearOccurence: ACoordinator: Michael BiggsMark Scheme: PGT Module Mark Scheme

Academic Year: 2018/9Module Level: PostgraduateScheme: PGDepartment: Cancer Studies & Molecular MedicineCredits: 60

Intended Learning OutcomesThe aim of this module is to introduce the innovative use of Post Mortem Radiology as a means to investigate natural orforensic death.

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Complete a supervised research project, applying the knowledge and skills taught from previous taught modules;2. Conduct a focused literature review;3. Define a relevant and answerable hypothesis or research question;4. Select appropriate research designs and methods of enquiry;5. Understand the need for ethical and governance approval where necessary;6. Demonstrate a rigorous and organized approach to data collection;7. Interpret and critically appraise the data collected;8. Interpret new findings in the context of the existing literature;9. Make recommendations for application of findings and topics for further research.

By the end of the module, students with reference to transferable skills will be able to:10. Critically develop dissertation writing and effective communication skills;11. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;12. Employ effective skills in IT basic office packages such as Word and Freeware DICOM Readers;13. Demonstrate ability to work effectively in groups and with a supervisor to problem solve;14. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition ofskills;15. Demonstrate organization skills and ability to time manage projects;16. Apply knowledge and skills to long term career goals and employability.

Teaching and Learning MethodsLectures, discussion, Q&A, debate, group work, directed study, independent study.

Assessment MethodsDissertation Essay (20,000 words excluding appendices)

Pre-Requisites-

Co-Requisites-



Lectures 3Seminars


FieldworkProject Supervision 6






MB7050 Dissertation




001 Essay 50 50002 Essay 50 50

Period: Semester 1Occurence: ACoordinator: Michael BiggsMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesThe aim of this module is to introduce the innovative use of Post Mortem Radiology as a means to investigate natural orforensic death.

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Describe, compare and contrast the use of XRAY, CT and MRI in Post Mortem Radiology;2. Discuss the history and current state of Post Mortem Radiology using case studies;3. Recall the importance of Ionising Radiations Regulations 1999;4. Examine the religious considerations within the adult death investigation process;5. Illustrate basic interpretation skills of Post Mortem Radiology scans.

By the end of the module, students with reference to transferable skills will be able to 6. Critically develop essay writing and effective communication skills;7. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;8. Employ effective skills in IT basic office packages such as Word;9. Demonstrate ability to work effectively in groups to problem solve;10. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition ofskills;11. Demonstrate organization skills and ability to time manage projects;12. Apply gained knowledge and skills to long term career goals and employability.


Assessment MethodsTwo essays (50% each)

Pre-Requisites-

Co-Requisites-











MB7051 Introduction to Post Mortem Radiology




001 Essay 50 50002 Essay 50 50

Period: Semester 1Occurence: ACoordinator: Frances HollingburyMark Scheme: PGT Module Mark Scheme


001 Essay 50 50002 Essay 50 50



Intended Learning OutcomesThe aim of this module is to introduce the innovative use of Post Mortem Radiology as a means to investigate natural orforensic adult death from a practical perspective.

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Discuss and debate the processes and issues (including managing change) in running a Post Mortem Radiology service;2. Explain and appreciate the importance of Post Mortem Computed Tomography (PMCT) protocols;3. Recognise and understand the theoretical and practical aspects of PMCT using lung ventilation, guided biopsy andangiography;4. Illustrate the practical aspects of reporting PMCT findings;5. Develop foundational knowledge and skills in workstation experience.

By the end of the module, students with reference to transferable skills will be able to:6. Critically develop essay writing and effective communication skills;7. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;8. Employ effective skills in IT basic office packages such as Word;9. Demonstrate ability to work effectively in groups to problem solve;10. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition ofskills;11. Demonstrate organization skills and ability to time manage projects;12. Apply knowledge and skills to long term career goals and employability.

Teaching and Learning MethodsLectures, discussion, Q&A, debate, group work, directed study, independent study, case studies, computer based.

Assessment MethodsEssay (3,000 words) – Practical technique applications (50%); Essay (3,000 words) – Practical technique applications(50%)









MB7052 Practical Aspects of Post Mortem Radiology



Pre-Requisites-

Co-Requisites-



MB7052 Practical Aspects of Post Mortem Radiology




001 10 study assessment cases 100 50

Period: Semester 1Occurence: ACoordinator: Bruno MorganMark Scheme: PGT Module Mark Scheme



Period: Semester 2Occurence: ACoordinator: Bruno MorganMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesThe aim of this module is to provide an advanced in depth overview and practical experience of the use of Post MortemRadiology when investigating adult natural death.

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Interrogate, interpret and report using Post Mortem Radiology scans the investigation of adult natural death due to bodysystems such as respiratory, cardiovascular, head and abdomen;2. Interrogate, interpret and report using Post Mortem Radiology scans the investigation of adult natural death due to medicalprocedures;3. Interrogate, interpret and report using Post Mortem Radiology scans the investigation of adult natural death due tocardiopulmonary resuscitation procedures.

By the end of the module, students with reference to transferable skills will be able to:4. Critically develop report writing within a medico legal context and effective communication skills;5. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;6. Employ effective skills in IT basic office packages such as Word and Freeware DICOM Readers;7. Demonstrate ability to work effectively in groups to problem solve;8. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition of skills;9. Demonstrate organization skills and ability to time manage projects;10. Apply knowledge and skills to long term career goals and employability.

Teaching and Learning MethodsLectures, discussion, Q&A, debate, group work, directed study, independent study, clinical demonstration, case studies,computer based.

Lectures 40Seminars








MB7053 Advanced Post Mortem Radiology - Adult Natural Death



Assessment MethodsThe assessment of each of the cases will be expanded. Instead of a report the student will be required to attempt 1 or more ofthe following:1. A task - for example: produce a 3D reconstruction of a spinal injury or undertake a curved MPR of the coronary arteries toshowing a major finding. This will need to be uploaded into Turnitin for assessment.2. Image findings report - They will be required to report on the Image findings, based on specific questions. For example theymay be asked to list the major abnormalities or propose a cause of death. Where appropriate there will also be clearlyidentified “supplementary” question e.g. what do you think of the xxx - any other minor findings? These questions are intendedto be beyond the ‘core’ knowledge required for PASS/FAIL and allow candidates to excel.3. Interpretation - They will be asked to interpret the image findings with medico-legal questions, for example, “What do youthink the cause of death is? Is there more than one potential cause of death? Which side were they hit from? Is this consistentwith a traumatic death?” They may also be requested to answer other “supplementary” questions (as described above), e.g.“what might an autopsy show that PMCT would not?, how safe would it be to give a cause of death?”.Interpretation questions may also suggest citation of “key references” in the answer, in order to demonstrate that the studenthas read around the subject in relation to the question posed.

Pre-RequisitesIntroduction to PMRPractical aspects of PMR

Co-Requisites-



MB7053 Advanced Post Mortem Radiology - Adult Natural Death







Intended Learning OutcomesThe aim of this module is to provide an in depth overview and practical experience of the use of Post Mortem Radiology wheninvestigating adult unnatural death centering on thermal injury, blunt trauma, projectile trauma and asphyxia.

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Illustrate advanced interpretation and reporting skills of Post Mortem Radiology scans for the investigation of unnaturaladult death due to thermal injury and blunt trauma.2. Demonstrate advanced interpretation and reporting skills of Post Mortem Radiology scans for the investigation of unnaturaladult death due to projectile trauma and asphyxia.

By the end of the module, students with reference to transferable skills will be able to: 3. Critically develop report writing within a medico legal context and effective communication skills;4. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;5. Employ effective skills in IT basic office packages such as Word and Freeware DICOM Readers;6. Demonstrate ability to work effectively in groups to problem solve;7. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition of skills;8. Demonstrate organization skills and ability to time manage projects;9. Apply knowledge and skills to long term career goals and employability.

Teaching and Learning MethodsLectures, discussion, Q&A, debate, group work, directed study, independent study, clinical demonstration, case studies,computer based.

Assessment MethodsThe assessment of each of the cases will be expanded. Instead of a report the student will be required to attempt 1 or more ofthe following:1. A task - for example: produce a 3D reconstruction of a spinal injury or undertake a curved MPR of the coronary arteries toshowing a major finding. This will need to be uploaded into Turnitin for assessment.2. Image findings report - They will be required to report on the Image findings, based on specific questions. For example theymay be asked to list the major abnormalities or propose a cause of death. Where appropriate there will also be clearlyidentified “supplementary” question e.g. what do you think of the xxx - any other minor findings? These questions are intendedto be beyond the ‘core’ knowledge required for PASS/FAIL and allow candidates to excel.3. Interpretation - They will be asked to interpret the image findings with medico-legal questions, for example, “What do youthink the cause of death is? Is there more than one potential cause of death? Which side were they hit from? Is this consistentwith a traumatic death?” They may also be requested to answer other “supplementary” questions (as described above), e.g.“what might an autopsy show that PMCT would not?, how safe would it be to give a cause of death?”.Interpretation questions may also suggest citation of “key references” in the answer, in order to demonstrate that the studenthas read around the subject in relation to the question posed.

Pre-RequisitesIntroduction to PMRPractical aspects of PMR

Lectures 20Seminars








MB7054 Advanced Post Mortem Radiology - Adult Unnatural Death I



Co-Requisites-



MB7054 Advanced Post Mortem Radiology - Adult Unnatural Death I




001 Research proposal 70 50002 Presentation 30 50

Period: Semester 2Occurence: ACoordinator: Guy RuttyMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesThe aim of this module is to prepare students to conduct research in the form of a dissertation in relation to the innovative useof Post Mortem Radiology as a means to investigate natural or forensic death

By the end of the module, students in regards to discipline specific knowledge and skills will be able to: 1. Understand how research can contribute to the development of practice and future further research;2. Recognise the range of disciplines that can contribute to research in relation to the use of Post Mortem Radiology;3. Formulate focused hypotheses or research questions with reference to Post Mortem Radiology and adult deathinvestigation;4. Demonstrate the importance of adhering to ethical procedures (including NHS), good research practice and governance;5. Appreciate the principles of research budgeting and timelines;6. Select appropriate research designs and methods for research within the subject of Post Mortem Radiology taking intoaccount the underpinning ontological and epistemological assumptions;7. Appreciate the principles of data collection e.g. observations, questionnaire, interviews, historical, journals etc.;8. Describe and present data of both a qualitative and quantitative nature using relevant data analysis software (e.g. SPSS,NVivo);9. Interpret and communicate research findings in a clear and appropriate format relevant to the research design.

By the end of the module, students with reference to transferable skills will be able to:10. Critically develop research proposal writing and effective communication skills including presentation skills;11. Appraise the strengths and weaknesses of research papers and evidence in image interpretation;12. Employ effective skills in IT basic office packages such as Word, Freeware DICOM Readers, PowerPoint, SPSS andNVivo;13. Demonstrate ability to work effectively in groups to problem solve;14. Reflect, appraise and evaluate own learning, showing the ability to identify areas that require increased acquisition ofskills;15. Demonstrate organization skills and ability to time manage projects;16. Apply knowledge and skills to long term career goals and employability.


Assessment MethodsResearch Proposal - 3,000 words (50%). Presentation Essay - 20 minutes (50%)

Pre-Requisites-

Co-Requisites-









MB7056 Research Designs in Applied Health





MB7056 Research Designs in Applied Health




001 Research Performance 35002 Research Report 57003 Research Seminar 8

Period: Semester 2Occurence: A18Coordinator:Mark Scheme: PGT Module Mark Scheme

Academic Year: 2018/9Module Level: PostgraduateScheme: PGDepartment: GeneticsCredits: 120

Intended Learning OutcomesStudents should be able to: research the literature relevant to their project topic; follow experimental instruction and protocolsto successfully execute experiments in a reproducible manner; interpret and analyse data; demonstrate the ability to managetheir time and laboratory activities; contribute to the planning of experimental investigations within the context of a researchproject.Students should be able plan and prepare a major scientific report. They should be able to prepare and deliver an appropriateoral presentation of their research aims, methods, data and conclusions.

Teaching and Learning MethodsProject supervision, project appraisals, independent research. Research proposal. Students are incorporated into researchgroup routines such as laboratory seminars, journal clubs and presenting oral reports of their work.

Assessment MethodsIndividual research project. Written report. Research seminar presentation.

Pre-Requisites

Co-Requisites



LecturesSeminars








MB7205 Masters Research Project




001 Experimental and data analysis 25002 Experimental and data analysis 25003 Experimental and data analysis 25004 Experimental and data analysis 25

Period: Semester 1Occurence: ACoordinator: Fred TataMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesStudents should be able to:Calculate molarities and plan the making of solutions; follow detailed experimental protocols and use them to executespecified experimental manipulations, such as plasmid DNA purification, genomic DNA purification, DNA restriction digestion,mRNA isolation, agarose gel electrophoresis, PCR amplification.Work with another student to plan and execute experimental procedures and record details of their experimentalmanipulations and data.Interpret research publications and apply their understanding to analyse their own experimental data. Write a clear account oftheir data analysis and interpretations.Analyse and compare DNA sequences using web-based resources.

Teaching and Learning MethodsLaboratory practical classes with embedded tutorial and problem-solving components. Computer practical classes. Lecturesand tutorials. Directed and self-directed reading. Information handling and numeracy.

Assessment MethodsCritical analyses of laboratory experimental investigations and interpretation of the resulting data. Observation of workingmethods and laboratory notebook.

Pre-Requisites

Co-Requisites











MB7211 Introduction to Techniques in Molecular Genetics and Data Analysis




001 Experimental and data analysis 15002 Exam (qualifying element) 30 45003 Exam 25004 Essay 30

Period: Semester 1Occurence: ACoordinator: Fred TataMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesStudents should:Demonstrate the ability to calculate concentrations and quantities required for producing laboratory solutions and reactionbuffers used in molecular biology;Be able to describe the activities of enzymes used in standard molecular genetic assays; describe and explain a range ofexperimental techniques used to identify and analyse genes, RNAs and proteins; apply their understanding of suchtechniques to devise experimental strategies to achieve set aims.Search literature databases and collate literature sources with citation-handling software; identify suitable primary researchpublications and interpret the research described therein; plan and write an essay that describes, explains and discusses aspecified topic of modern molecular genetics research. Students should assess the impact and prospects of the researchinvestigations they have researched.Demonstrate an understanding of a variety of modern experimental techniques in molecular genetics and molecular biology.

Teaching and Learning MethodsLaboratory practical classes. Lectures and tutorials. Surgeries. Directed and self-directed reading. Information handling andnumeracy. Independent research.

Assessment MethodsCritical analyses of the laboratory experimental investigations and interpretation of the resulting data. Essay (3000 wordminimum). Multiple choice examination.Examination that includes problem-based questions, short-answer questions and essay questions. This examination is aqualifying element and a student must achieve a mark of 45% in the examination to pass the module.

Pre-Requisites

Co-Requisites











MB7212 Experimental Design and Application of Molecular Genetic Techniques toResearch




001 Poster presentation (Qualifying Element) 25002 Lecture report (Qualifying element) (Final) 25003 3000 word essay (Qualifying element) 50

Period: Semester 1Occurence: ACoordinator: Cordula StoverMark Scheme: PGT Module Mark Scheme

Academic Year: 2018/9Module Level: PostgraduateScheme: PGDepartment: Infection, Immunity and InflammationCredits: 20

Intended Learning OutcomesSynopsis: This module will run in the second part of Semester 1 (weeks 7-12) and comprises lectures, tutorials and student-led presentations on more advanced subjects within the fields of Infection and Immunity. It builds on the two modules run inweeks 1-6 on Infectious Disease (MB7302) and Immunity (MB7303) and offers a guided opportunity to integrate a basicunderstanding of the subject areas with topical and “cutting-edge” knowledge of developments in our understanding of theinteraction between pathogenic organisms and the immune system. Aims: The module has two clear aims: firstly to further the understanding of how immunology and bacteriology/parasitologyapply to acute problems of public and world health and, secondly, to assist the student in presenting an informed opinion onsome of these complex problems and issues. Objectives: By the end of the module, students should be able to:- have a clear concept of mucosal tolerance, immune privilege and the role of chronic inflammation in theimmunopathogenesis of microbiological based diseases as well as the development of cancer- contrast cellular and humoral mediators of both acute and chronic inflammation - evaluate different types of vaccines and the immune responses they elicit- describe the pathogenic mechanisms involved in infectious diseases of pandemic importance- contrast the immune response to bacteria, viruses and prions- outline the importance of pathogenicity islands- discuss the genetic evidence for natural selection of pathogen resistance alleles in humans - describe examples of alleles conferring resistance to different human pathogens and explain their distribution in modernpopulations - evaluate the importance of phages in infection and disease management - delineate the mechanisms bacteria employ to evade the host’s immune response- classify immune deficiencies on the basis of defined mechanistic evidence

Teaching and Learning MethodsLectures, tutorials and presentations

Assessment MethodsPresentations, lecture report and 3000 word essay

Pre-Requisites

Co-Requisites



Lectures 45Seminars








MB7305 Advanced Topics in Infection and Immunity




001 Poster presentation 10002 Supervisor's report on lab performance 35003 Written dissertation (up to 15,000 words) 55

Period: Semester 2Occurence: ACoordinator: Alan BevingtonMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesOn successful completion of the module, students should be able to: - Demonstrate practical and theoretical competence in key experimental methods, competent use of standard and specializedequipment, knowledge of safety procedures and safety assessment.- Critically appraise complex theoretical and technical evidence accurately and rigorously in the context of the publishedliterature.- Demonstrate competence in written and poster presentation methods, and ability to discriminate between relevant and non-relevant material and to prioritise and present in a logical sequence.- Perform literature review, experimental design, essential laboratory methods, problem solving, data analysis, and statisticalanalysis.- In the Erasmus programme, demonstrate the capacity to work in a research laboratory and study in another EuropeanUniversity

Teaching and Learning MethodsLaboratory research project and project supervision

Attendance at departmental or college research seminars

Assessment MethodsOral or poster presentation, supervisor's report on laboratory performance, written dissertation.

Pre-Requisites

Co-RequisitesNone

Excluded CombinationsNone

Guided Independent Study: Indicative ActivitiesStudy of research literature and experimental design under the guidance of research project supervisor; writing up laboratoryexperiments; independent preparation of laboratory research materials and running of experiments; laboratory data analysisand relevant statistical analysis; literature searching and writing of research dissertation and research poster.

LecturesSeminars 20




Supervised time in studio/workshop 730Work Based Learning




MB7306 Research Laboratory Project




001 MCQ 20 1002 3000 word essay 30003 Practical-based set questions 10004 Practical write-up 20005 Oral Presentation 20 1



Intended Learning OutcomesOn successful completion of the module, students should be able to:- Explain a wide range of theories and mechanisms that provide the basis of research on infection and immunity- Demonstrate practical and theoretical competence in key experimental methods, competent use of standard and specializedequipment, knowledge of safety procedures and safety assessment.- Demonstrate competence in written, oral and poster presentation methods, ability to discriminate between relevant and non-relevant material, prioritisation, and presentation in a logical sequence.- Critically appraise scientific results in the context of the published literature.

Teaching and Learning Methods1) Lectures and tutorials. (Student contributions to tutorials will be both peer-reviewed and lecturer-reviewed).2) Laboratory-based practicals and demonstrations3) Personal mentoring during preparation of extended 3000 word essay4) Hands-on experience with laboratory equipment & bibliographic/data analysis software.

Assessment MethodsMCQ - 20%Oral Presentation - 20%Practical-based set Questions - 10%Practical write-up - 20%3000 word essay - 30%

Pre-RequisitesNone

Co-RequisitesNone


Guided Independent Study: Indicative ActivitiesStudy of review articles, textbooks, Practical Handbook and video/online resources recommended on Blackboard; preview ofPowerpoint presentations on Blackboard prior to teaching sessions; clarification and digestion of lecture and tutorial notesassistedby Panopto recordings; writing up laboratory practicals & demonstrations; literature searching and writing of extended essay.

Lectures 44Seminars








MB7308 Core Theory & Practical Techniques in Infection & Immunity




001 MCQ Infection 20 1002 MCQ Immunity 20 1003 SAQ Infection 20 1004 SAQ Immunity 20 1005 Poster Presentation 15006 Lecture Report 5



Intended Learning OutcomesOn successful completion of the module, students should be able to:- Explain the molecular and cellular biology and pathological mechanisms that underlie a wide range of communicable humandiseases and the immune response to them- Weigh and draw balanced conclusions from complex theoretical and technical evidence accurately and rigorously.- Critically appraise scientific results in the context of the published literature.

Teaching and Learning MethodsLectures, tutorials, and mentoring in preparation for poster presentation and lecture report

Assessment MethodsMCQ Infection - 20%MCQ Immunity - 20%SAQ Infection - 20%SAQ Immunity - 20%Poster Presentation - 15%Lecture Repart - 5%

Pre-RequisitesNone

Co-RequisitesNone


Guided Independent Study: Indicative ActivitiesStudy of review articles, textbooks and video/online resources recommended on Blackboard; preview of Powerpointpresentations on Blackboard prior to teaching sessions; clarification and digestion of lecture and tutorial notes assisted byPanopto recordings; literature searching and writing of lecture report and poster presentation.

Lectures 50Seminars








MB7309 Infection & Immunity




001 Poster presentation 25002 Lecture report (Final) 25003 3000 word essay 50



Intended Learning OutcomesSynopsis: This module will run in the second part of Semester 1 (approximately weeks 7-12) and comprises lectures, tutorialsand student-led presentations on more advanced subjects within the fields of chronic disease and inflammation. It builds onthe two modules run in approximately weeks 1-6 on Fundamental Processes of Inflammation (MB7312) and Immunity(MB7303) and offers a guided opportunity to integrate that material with topical and “cutting-edge” developments on the roleof inflammation in the progression of specific chronic diseases. Aims: This module has three aims:1) To build upon Module MB7312 by presenting more advanced material on inflammatory mechanisms, and animal modulesthat are used to study them.2) To illustrate these principles by showing the important role of chronic inflammation in the progression of a range of clinicallyimportant groups of diseases, e.g.diabetes, cardiovascular disease, renal disease, lung disease, and bone and joint disease, 3) To demonstrate the world-wide scale and human cost of progressive inflammatory disease, the limitations of current drugtherapy, and the potential role of non-drug therapy including dietary manipulation and exercise.Objectives: By the end of the module, students should be able to: -Describe the role of coagulation, kinin and fibrinolytic cascades, pathological growth, and integrin biology in inflammatorydisease progression-Describe the ethical and practical limitations of animal disease models in inflammation-Demonstrate how the principles of inflammation biology taught in modules MB7312 and MB7303 and the present module canbe used to explain disease progression in specific chronic degenerative diseases-Describe the limitations of current anti-inflammatory therapies and feasible targets for research on novel therapies in thisfield.

Teaching and Learning MethodsLectures, tutorials and presentations

Assessment MethodsPoster presentation, lecture report and 3000 word essay

Pre-Requisites

Co-Requisites



Lectures 45Seminars





PlacementYear Abroad 0



MB7315 Advanced Topics in Chronic Disease and Inflammation




001 Poster presentation 10002 Supervisor's report on lab performance 35003 Written dissertation (up to 15,000 words) 55



Intended Learning OutcomesSynopsis: This module comprises a six-month research project placement within the Department of Infection, Immunity andInflammation; or a research laboratory within the College. The student may choose a research project from a pool ofsubmitted outlines after meeting with potential supervisors.

Aims: To provide the student with a suitable project that utilises modern methods of molecular and cellular biology toinvestigate a research problem relevant to chronic disease & inflammation.

Objectives: By the end of the module, students should be able to: - present a written synopsis of the background to a research project; - demonstrate understanding of the design of experiments, including the importance and nature of controls;- analyse data; - logically develop a series of different experimental approaches; - prepare a sound summary; - extract from the project the principal findings, and present them in a logical and coherent way.- demonstrate advanced practical skills within the field of study

Teaching and Learning MethodsLaboratory research project

Assessment MethodsOral or poster presentation, supervisor's report on laboratory performance, written dissertation

Pre-RequisitesSemester 1 taught modules

Co-RequisitesNone



LecturesSeminars 20








MB7316 MSc Laboratory Research Project




001 MCQ 20 1002 Oral Prersentation 20 1003 Practical-based set questions 10004 Practical write-up (Final) 20005 3,000 word essay 30



Intended Learning OutcomesOn successful completion of the module, students should be able to: - Explain a wide range of theories and mechanisms that provide the basis of research on inflammation and chronic disease- Demonstrate practical and theoretical competence in key experimental methods, competent use of standard and specializedequipment, knowledge of safety procedures and safety assessment.- Demonstrate competence in written and oral presentation methods, ability to discriminate between relevant and non-relevantmaterial, prioritisation, and presentation in a logical sequence.- Critically appraise scientific results in the context of the published literature.

Teaching and Learning Methods1) Lectures and tutorials. (Student contributions to tutorials will be both peer-reviewed and lecturer-reviewed). 2) Laboratory-based practicals and demonstrations3) Personal mentoring during preparation of extended 3000 word essay4) Hands-on experience with laboratory equipment & bibliographic/data analysis software.

Assessment MethodsMCQOral presentation3,000 word Essay Practical-based set questionsPractical write-up

Pre-RequisitesNone

Co-RequisitesNone


Guided Independent Study: Indicative ActivitiesStudy of review articles, textbooks, Practical Handbook and video/online resources recommended on Blackboard; preview ofPowerpoint presentations on Blackboard prior to teaching sessions; clarification and digestion of lecture and tutorial notesassisted by Panopto recordings; writing up laboratory practicals & demonstrations; literature searching and writing ofextended essay.

Lectures 44Seminars








MB7318 Core Theory & Practical Techniques in Chronic Disease & Inflammation




001 MCQ Inflammation exam 20 1002 MCQ Immunity exam 20 1003 SAQ Inflammation exam 20 1004 SAQ Immunity exam 20 1005 Poster (final) 15006 Lecture report 5



Intended Learning OutcomesOn successful completion of the module, students should be able to:- Explain the disease progression paradigm and pathological mechanisms that underlie a wide range of chronic degenerativehuman diseases- Weigh and draw balanced conclusions from complex theoretical and technical evidence accurately and rigorously. - Critically appraise scientific results in the context of the published literature.- Demonstrate competence in written and poster presentation methods, ability to discriminate between relevant and non-relevant material, prioritisation, and presentation in a logical sequence

Teaching and Learning MethodsLectures, tutorials, and mentoring in preparation for poster presentation and lecture report

Assessment MethodsMCQ and SAQPoster presentation Lecture report

Pre-RequisitesNone

Co-RequisitesNone


Guided Independent Study: Indicative ActivitiesStudy of review articles, textbooks and video/online resources recommended on Blackboard; preview of Powerpointpresentations on Blackboard prior to teaching sessions; clarification and digestion of lecture and tutorial notes assisted byPanopto recordings; literature searching and writing of lecture report and poster presentation.

Lectures 50Seminars








MB7319 Immunity & Inflammation




001 Data analysis and critical interpretation 1 15002 Data analysis and critical interpretation 2 25003 Data interpretation examination (Final) 60 45 2.5

Period: Semester 1Occurence: ACoordinator: David GutteryMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesOn successful completion of the module, students should be able to:• Crticially describe and discuss the principles of molecular pathology in relation to cancer.• Critically explain the key molecular changes that take place during the progression of a cell from normal to malignant.• Demonstrate a critical understanding of the roles and mechanisms of apoptosis, angiogenesis, metastasis, oxidative stress,genome stability and immunology in cancer development and tumour biology.• Demonstrate critical insight of the principles behind cancer epidemiology and factors relating to cancer risk.• Demonstrate a critical understanding of the comparative use of different laboratory methodologies of relevance to molecularpathology and therapeutics of cancer, in terms of applicability, sensitivity, reproducibility and validity.• Present and critically appraise data in the context of the scientific literature.Transferable skills: Major (summatively assessed):Undertake data analysis, interpretation and presentation using statistics and numeracy skills.Solve complex problems where data are incomplete or contradictory.Communicate complex issues in writing (or in written and oral format)Carry out literature searches using appropriate tools.

Minor (non assessed):Balance competing demands to complete work on time.Work effectively as part of a team to produce agreed outcomes.Use opportunities for own development and plan appropriate activities to work towards stated goals.

Teaching and Learning MethodsLectures. Tutorials. Laboratory practical classes.

Assessment Methods001 Data analysis and critical interpretation 1002 Data analysis and critical interpretation 2003 Data interpretation examination (Final)

Pre-Requisites

Co-Requisites


Guided Independent Study: Indicative ActivitiesResearching and preparing for laboratory practical classes; Researching for and preparing laboratory class reports: Preparingfor tutorials; Exam revision



Fieldwork 0Project Supervision 0


Supervised time in studio/workshop 0Work Based Learning 0

Placement 0Year Abroad 0



MB7401 Molecular Pathology & Cell Biology of Cancer



MB7401 Molecular Pathology & Cell Biology of Cancer




001 Bioinformatics analysis 10002 Data analysis and interpretation 2 20003 Statistical methods and appraisal 20004 Multiple choice question exam (Final) 50 45 1.5

Period: Semester 1Occurence: ACoordinator: Donald JonesMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesOn successful completion of the module, students should be able to:- Summarize and present different types of data appropriately, and perform simple hypothesis tests pertinent to the data usingan appropriate statistical software package.- Demonstrate use of online bioinformatics/nucleic acid sequence databases for sequence comparisons and PCR primerdesign.- Show effective use of a bibliographic database/reference management software to search the scientific literature andgenerate bibliographies.- Demonstrate a comprehensive understanding of the theory and practice of key molecular biology techniques.- Demonstrate effective laboratory report writing skills to summarise present and critically appraise data in the context of thescientific literature.- Transferable skills: Major (summatively assessed):Undertake data analysis, interpretation and presentation using statistics and numeracy skills.Solve complex problems where data are incomplete or contradictory.Communicate complex issues in writingCarry out literature searches using appropriate tools.- Minor (non summatively assessed):Balance competing demands to complete work on time.Work effectively as part of a team to produce agreed outcomes.Use opportunities for own development and plan appropriate activities to work towards stated goals.

Teaching and Learning MethodsLectures. Tutorials. Laboratory practical classes. Computer practical classes. Demonstrations. Seminar.

Assessment Methods001 Bioinformatics analysis002 Data analysis and interpretation 2003 Statistical methods and appraisal004 Multiple choice question exam (Final)

Pre-Requisites

Co-Requisites










MB7402 Molecular Methods & Experimental Design



Guided Independent Study: Indicative ActivitiesResearching and preparing for laboratory practical classes; Researching for and preparing laboratory class reports; Examrevision

MB7402 Molecular Methods & Experimental Design




001 Written Examination (Final) 60 2.5003 Experimental Design 40

Period: Semester 2Occurence: ACoordinator: Karen BrownMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesOn successful completion of the module, students should be able to:• Describe the types of biomarkers used for cancer diagnosis/prognosis, and critically explain their discovery, validation, useand relative benefits.• Describe and critically discuss the principles of chemoprevention and strategies for evaluating chemopreventive agentefficacy.• Explain and critique the primary approaches to cancer therapy and monitoring of disease.• Critically discuss the principal mechanisms of action underlying chemotherapy, radiotherapy, immunotherapy and biologictherapy of cancer.• Demonstrate a critical understanding of how tumour cells develop resistance to therapy and strategies for overcomingresistance.• Insightfully describe and discuss the ethical issues surrounding cancer research and treatment and the influences of diet,lifestyle and socio-economic status on cancer risk and survival.• Critically elucidate the process of drug target discovery, target validation, drug design and stages of testing for clinical utility.- Transferable skills: Major (summatively assessed):Critically communicate complex issues in writing. Solve complex problems where data are incomplete or contradictory.Carry out literature searches using appropriate tools.Study design to test a hypothesis.

Minor (non assessed):Balance competing demands to complete work on time.Work effectively as part of a team to produce agreed outcomes.Use opportunities for own development and plan appropriate activities to work towards stated goals.

Teaching and Learning MethodsLectures. Tutorials. Demonstrations.

Assessment MethodsWritten examination (Final) Experimental design report

Pre-Requisites

Co-Requisites


Lectures 31Seminars








MB7403 Cancer Therapeutics



Guided Independent Study: Indicative ActivitiesResearching and preparing for workshop; Researching for and preparing workshop report: Preparing for tutorials;researching and preparing for final written exam

MB7403 Cancer Therapeutics




001 Poster Presentation 5002 Seminar Presentation (Final) 5003 Research Performance 35004 Dissertation 55

Period: Semester 2Occurence: A18Coordinator: George JonesMark Scheme: PGT Module Mark Scheme


Intended Learning OutcomesOn successful completion of the module, students should be able to:• Critically analyse, appraise and summarise scientific literature for oral presentation; demonstrate effective oral presentationskills.• Perform background research into a project, critically appraising relevant literature and forming hypotheses.• Design and implement experiments/other data collection protocols.• Critically analyse, interpret and present data.• Demonstrate effective communication of research project background and outcomes.Transferable skills: Major (summatively assessed):Study design to test a hypothesis.Manage time and resources in undertaking a research project.Work effectively as part of a team to produce agreed outcomes.Balance competing demands to complete work on time. Undertake data analysis, interpretation and presentation using statistics and numeracy skills.Critically communicate complex issues in written and oral format. Solve complex problems where data are incomplete or contradictory.Carry out literature searches using appropriate tools.

Minor (non assessed):Use opportunities for own development and plan appropriate activities to work towards stated goals.

Teaching and Learning MethodsIndependent research (inc. experimental instruction & design; data recording, analysis & interpretation). Directed reading/guided independent study. Supervisory meetings. Seminars.

Assessment Methods001 Poster presentation002 Seminar presentation (Final)003 Research performance004 Dissertation

Pre-RequisitesMB7401. MB7402. MB7403.

Co-Requisites

LecturesSeminars 20








MB7404 MSc. Research Project




Guided Independent Study: Indicative ActivitiesResearching and preparing for poster and oral presentations (inc. critical data analysis & Journal Club (formative));Researching for and preparing dissertation (inc. critical data analysis) and project literature review. Preparing for andresponding to supervisor meetings.

MB7404 MSc. Research Project


Documents

Module Specification · 2021. 9. 1. · Module Specification No. Assessment Description Weight % Qual Mark Exam Hours Ass't Group Alt Reass't 001 Examination (Final) 50 1.5 002 Practical