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The Good, the Bad, and the Mean (µ): Limitations and Extensions of Latent Growth Curves in Health Disparities Research. Miles Taylor, Ph.D. Florida State University. What is Growth Curve Analysis?. - PowerPoint PPT Presentation
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THE GOOD, THE BAD, AND THE MEAN (µ): LIMITATIONS AND EXTENSIONS OF LATENT GROWTH CURVES IN HEALTH
DISPARITIES RESEARCH
Miles Taylor, Ph.D.Florida State University
WHAT IS GROWTH CURVE ANALYSIS? The broad category of models includes
multiple types of models (from multiple traditions) that are used to analyze individual change using more than 2 time points
Ex’s: latent growth curve analysis, latent trajectory analysis, random effects models, hierarchical linear models, etc.
Note that “curve” does not necessarily mean a nonlinear trend. On the contrary, most of the growth “curves” predicted by these various types of models are linear.
Examples: trajectories of reading ability in children, depressive symptoms across the life course, tumor growth in rats
1982 1984 1989 1994
1999
1984 1989 19941982 1984 1989 1994
1999
UNCONDITIONAL MODEL
Level 1 model:
Level 2 model:
Combined
1
1 1
1 0
1 2
βα
3
y1 y2y3
ε3
y4
ε4ε2ε1
ittiiity
iai
iyi
1999
)()( itttit iiy
STRUCTURAL EQUATION MODELS (SEM) Structural Equation Models (SEM) refer
to a broad class of powerful models Instead of emphasizing cases, SEM
emphasizes variances/covariances. This allows testing whether and how
variables are interrelated in a set of linear relationships
The acronym is sometimes switched for simultaneous equation modeling (SEM) since it can handle many interrelated equations that are jointly estimated
WHY CHOOSE A STRUCTURAL EQUATION MODELING (SEM) APPROACH TO GROWTH CURVES?
Various forms of measurement error Estimators and fit indices for
continuous, dichotomous, or ordinal repeated measures
Flexibility in handling time Statistical packages like Mplus make
more complex models possible Other approaches do have advantages
in some instances, such as observations at different time points
THE GOOD Improvement over aggregate change
approaches – not Markovian or semi-Markovian Can incorporate many repeated observations Can handle time invariant and time variant
covariates as well as repeated outcomes Can be combined in an SEM context Allow examination of life course developmental
processes, testing developmental theories Can examine whether inequalities or disparities
are persistent, increasing, etc. over time both within and across individuals
EXAMPLE OF THE GOOD
Valle, G. Thomas, K. & Taylor, M. G. “Parental Incarceration: Influences on Children’s Mental Health during the Transition to Adulthood”
EXAMPLE OF THE GOOD
• Valle, G. Thomas, K. & Taylor, M. G. “Parental Incarceration: Influences on Children’s Mental Health during the Transition to Adulthood”
WHY IT WORKS
The findings from the alpha and beta (intercept and slope) were meaningful in a life course context (persisting inequality changes to an underlying effect emerging in adulthood)
Individual loadings were freed and then fixed, allowing more complex nonlinearity to be modeled
The outcome is easily thought of as developmental / continuous in nature
The treatment was estimated before W1
THE BAD (1) PEOPLE OR PATTERNS ARE “MISSED” Level 1 equation parameterizes individual
trajectories before calculating their variation from the mean
Model specification (linear, quadratic, etc.) is based on the average trajectory specification
Trajectory methodologists acknowledge we should free the loadings but we trade parsimony and therefore fit
What if some collection of the trajectories is nonlinear and meaningful
What if timing of the developmental process is important?
1982 1984 1989 1994
1999
1984 1989 19941982 1984 1989 1994
1999
EXTENSIONS
Group-based modeling strategies can handle this efficiently (latent class analysis of trajectories, finite mixture models, growth mixtures with freed loadings)Work of Nagin, Land, Muthen
Hybridized models can handle this where “onset” of developmental process varies at random.Work of Albert & Shih (2003), Taylor (2008;
2010), and Haas & Rohlfson (2010)
GROUP TRAJECTORY EXAMPLE1908-1917 Cohort (Aged 65-74)
1
2
3
4
5
6
1980 1985 1990 1995 2000
Year
Dis
abili
ty
No/LowDis.Delayed
Mild Lin.
Mod. Lin.
Prec. Inc.
High Lin.
WHY IT WORKS Shows that there is more than one average
trajectory and multiple forms of meaningful nonlinearity.
Efficiently models linear trajectories like linear along with a lagged onset, etc.
Referent group is no longer the mean trajectory. It is assumed to be the most prevalent group by default but may be set to any meaningful experience (here: nondisabled over the period)
Covariates are thus used to predict patterns rather than high/low on intercept and slope/s.
RANDOM ONSET MODEL
Taylor, Miles G. 2010. “Capturing Transitions and Trajectories: The Role of Socioeconomic Status in Later Life Disability.” Journals of Gerontology: Social Sciences 65B: 733-743
1912-1921 Cohort Age 65-74 N=2,456Covariate Model Including Education
Haz. O.R. 95% C. I. Int. S.E. Slope S.E.
Men 0.638*** [0.549 - 0.727] 0.033 (0.202) -0.055 (0.108)White 0.852*** [0.735 - 0.969] -0.208 (0.206) 0.208* (0.104)Age 1.051*** [1.027 - 1.076] -0.069***(0.033) 0.050*** (0.017)Educ 0.889*** [0.871 - 0.906] 0.019 (0.026) -0.031*** (0.013)Mort. 2.646*** [2.262 - 3.030] 1.570*** (0.199) 0.447*** (0.126)Intercept --- --- 6.213*** (2.308) -2.456*** (1.165)Var. --- --- 5.501*** (0.506) 0.885*** (0.154)Cov (Int, Slp) --- --- -0.660***(0.257)
1986/87 1989 1992 1996Threshold 3.814*** 3.874*** 3.622*** 3.008***
(0.817) (0.818) (0.818) (0.817)
Loglikelihood -8576.758 (28) BIC 17372.093
)(
WHY IT WORKS A second process (here: first onset) is modeled.
Therefore, the growth curves only include nonzero values.
Delayed onset (modeled through a discrete time hazard) captures the meaningful nonlinearity of the disability trajectories.
This means that one can reconcile findings from state based (transition) and developmental trajectory literatures
It also means covariates can predict these simultaneous processes in shared or independent ways
THE BAD (2) SELECTION PROCESSES
Selection into the observation window with/without starting the developmental process (meaningful partial left censoring)
Random onset model handles this better than traditional LGC’s
EXTENSION: RANDOM ONSET
Dis
abil
ity
Dis
abil
ity
Age Age
Black
White
65 70 75 80
White
60
White
Black
65 70 75 80 0
1
3
2
4
5
6
65
Observed Estimated
650
1
3
2
4
5
6
• Taylor, Miles G. 2008. “Timing, Accumulation, and the Black/White Disability Gap in Later Life: A Test of Weathering.” Research on Aging: Special Issue on Race,SES, and Health 30: 226-250.
EXTENSION: RANDOM ONSET
N=3,941
Intercept Slope Onset (Hazard O.R.) Intercept SlopeBlack 0.28*** 0.13*** 1.54*** 0.07 -0.02Age 0.10*** 0.10*** 1.11*** 0.07*** 0.06***Intercept -6.34*** -6.06*** --- -2.93*** -3.38***Var. 3.84*** 1.28*** --- 6.89*** 1.30***Cov. 0.47*** --- --- --0.88*** ---
R20.10 0.24 --- 0.04 0.11
LL -40673.84 (13) -15970.76 (19)BIC 81455.31 32098.83
*p<.05, **p<.01, ***p<.001.
(A) Growth Curve (B) Growth Curve with Random Onset
),( ),(
• Taylor, Miles G. 2008. “Timing, Accumulation, and the Black/White Disability Gap in Later Life: A Test of Weathering.” Research on Aging: Special Issue on Race, SES, and Health 30: 226-250.
WHY IT WORKS A second process (here: first onset) is
modeled. Therefore, the growth curves only include nonzero values.
Traditional LCG’s returned findings supporting a cumulative disadvantage theory.
Random onset model reveals that in this sample, the disparity lies in the onset process.
Black individuals were more likely to select into the sample with some nonzero level of disability, but their process of accumulation thereafter was not significantly different from whites.
THE BAD (2) SELECTION PROCESSES
Selection out of the sample that is meaningful (attrition, mortality selection)
Transition models (survival, etc.) have specific extensions for this (competing risk/multiple decrement)
In traditional LCG’s, the best we get is to “include” those until they drop out or include some kind of “control” for attrition
THE BAD (2) SELECTION PROCESSES
With SEM it is possible (just like in the random onset model) to include additional equations to handle this transition (either time variant or no)
This means we can include a parallel joint process (like the random onset model) but this time it is a timing of exit
A.K.A., one can create a sort of competing risk between changes in the developmental process of the outcome over time vs. attrition/death
EXTENSION: ATTRITION PROCESS
Taylor, Miles G. and Scott M. Lynch. 2011. “Cohort Differences and Chronic Disease Profiles of Differential Disability Trajectories”. Journals of Gerontology: Social Sciences. 66B: 729-738.
EXTENSION: ATTRITION PROCESS
Taylor, Miles G. and Scott M. Lynch. 2011. “Cohort Differences and Chronic Disease Profiles of Differential Disability Trajectories”. Journals of Gerontology: Social Sciences. 66B: 729-738.
Cohort Effects, N=16,264Classes High Moderate Mild Increasing MortalitySample % 2.742% 4.808% 3.191% 10.613% ---CovariatesAge 1.258*** 1.219*** 1.140*** 1.182*** 1.115***Black 2.726*** 2.581*** 2.694*** 1.812*** 1.335***Female 1.149 1.415*** 1.310*** 1.290*** 0.486***1920-24 Cohort 0.679*** 0.653*** 0.603*** 1.050 0.9411925-29 Cohort 0.627*** 0.753*** 0.632*** 0.975 0.908***
-28525.773(49)BIC 57526.684Entropy 0.926
Loglikelihood (Number of Parameters)
WHY IT WORKS The second process here is mortality, and
this I can model jointly with disability. A.K.A they affect one another over time.
Here I was primarily interested in cohort differences, and allowing these covariates to impact both disablement trajectories and death inform findings on the compression of morbidity.
Chronic diseases were also included in later models, and these impacts I could see on disability over the decade net of death and vice versa.
SUMMARY Potential weaknesses of traditional LGC’s:
People or meaningful patterns are missed through misspecification in the level 1 equation
Extensions: Multiple ways to “disentangle” or unpack
the mean growth or important deviations from itConsider group based trajectories for
modeling meaningful nonlinearity efficiently
Inclusion of additional processes (onset, recovery, etc.)
SUMMARY
Potential weaknesses of traditional LGC’s:Differential Selection: into the sample
on level of outcome, out of the sample Extensions:
Random onset as simultaneous process for partial left censoring
Mortality or other meaningful attrition as a simultaneous process
CONCLUSIONS
Latent Growth Curve (LGC) modeling in an SEM framework is extremely versatile due to the ability to model equations simultaneously
New softwares for SEM/Latent variable modeling (a.k.a. Mplus) allow more flexibility in modeling noncontinuous endogenous/outcome variables
Documentation now exists on replicating standard models like simply discrete-time hazard and finite mixtures/cluster analysis in the SEM context.
It’s time to move beyond the mean, beyond the noise.