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Microbiology: A Systems Approach, 2nd ed.
Chapter 18: Infectious Diseases Affecting the Skin and Eyes
Figure 18.1
Skin Defenses
• Keratinized surface• Constant sloughing off of cells from the
stratum corneum• Antimicrobial substances
– Sebum– Sweat– Antimicrobial peptides in epithelial cells
18.3 Normal Biota of the Skin
• Must be able to live in dry, salty conditions• Microbes grow in dense populations in moist
areas and skin folds or in hair follicles and glandular ducts
Three Main Categories• Diphtheroids
– Club-shaped– Gram positive– Not usually virulent– Propionibacterium acnes
• Microcci– Staphylococcus and Micrococcus– S. epidermis
• Yeasts – Low numbers, can cause opportunistic disease– Candida albicans– Malassezia
18.4 Skin Diseases Caused by Microorganisms
• Acne– All follicle-associated lesions– Skin prone to pimples and acne
• Structure that traps the mass of sebum and dead cells, clogging the pores
• Exaggerated process of keratinization in and around the follicle, blocking the pore
• Overproduction of sebum when the sebaceous gland is stimulated by hormones
– Propionibacterium acnes in the follicle releases lipases to digest the oil surplus, results in intense local inflammation that can eventually burst the follicle
Types of Lesions in Acne
• Comedo: skin initially swells over the pore leading out of a hair follicle– Pore closed- whitehead– Pore open but blocked with a dark plug of sebum-
blackhead• Pustule or papule: when the lesion erupts on
the surface• Cysts: pustules that come to involve deeper
layers of skin
Impetigo• Superficial bacterial infection• Causes the skin to flake or peel off • Highly contagious• Usually seen in children• Either Staphylococcus aureus or Streptococcus
pyogenes• Looks like peeling skin, crusty and flaky scabs, or
honey-colored crusts• Lesions usually found around mouth, face, and
extremities• Itches
Figure 18.2
Figure 18.4
Cellulitis
• Caused by a fast-spreading infection in the dermis and the subcutaneous tissues
• Causes pain, tenderness, swelling, and warmth
• Lymphangitis often occurs
Staphylococcal Scalded Skin Syndrome (SSSS)
• Dermolytic condition• Caused by Staphylococcus aureus• Mostly in newborns and babies• Can be thought of as a systemic form of
impetigo• Bullous lesions• Desquamation of the skin
Figure 18.7
Gas Gangrene
• Clostridial myonecrosis• Caused by Clostridium perfringens• Two forms
– Anaerobic cellulitis– True myonecrosis
Figure 18.8
Chickenpox• Generally a mild disease• In immunocompromised people, can be life
threatening• Fever and abundant rash that begins on scalp,
face, and trunk; radiates in sparse crops to the extremities (centripetal distribution)
• Lesions form macules and papules to itchy vesicles filled with a clear fluid
• In several days, encrust and drop off• Shingles: the virus enters the sensory endings
that innervate dermatomes and becomes latent- them reemerges
Figure 18.10a
Figure 18.11
Smallpox• Naturally occurring smallpox no longer occurs,
but may be a bioterrorism threat• Fever and malaise, then a rash in the pharynx• Spreads to the face and progresses to the
extremities• Initially a macular rash, then turns to popular,
vesicular, and pustular before crusting over• Two forms
– Variola minor– Variola major
• Highly virulent• Causes toxemia, shock, and intravascular coagulation
Figure 18.10b
Maculopapular Rash Diseases
• Measles• Rubella• Fifth disease• Roseola
Measles• Also known as rubeola• Sore throat, dry cough, headache, conjunctivitis,
lymphadenitis, and fever• Koplik’s spots appear then turn in to red
maculopaular exanthem• Erupts on the head then progresses to the trunk
and extremities until most of the body is covered• Complications can result
– Pneumonia– Laryngitis– Secondary bacterial infections– Subacute sclerosing panencephalitis (SSPE)
Figure 18.12
Rubella
• Also known as German measles• Relatively minor rash disease with few
complications• Two forms
– Postnatal infection– Congenital infection
• Teratogenic virus• Transmission of virus to a fetus in utero• Mother can transmit the virus even if she is asymptomatic• Fetal injury varies depending on the time of infections
Fifth Disease
• Erythema infectiosum• “slapped-cheek” appearance• Spreads on the body but is most prominent on
arms, legs, and trunk• Maculopapular, blotches run together• Low-grade fever and malaise
Roseola
• Common in young children and babies• Most cases proceed without the rash stage;
others result in maculopapular rash• High fever• Fourth day, fever disappears, and rash can
appear
Scarlet Fever
• Most often the result of a respiratory infection with Streptococcus pyogenes
Warts
• Also known as papillomas• Affect children more than adults• Benign squamous epithelial growths• Various types
– Seed warts– Genital warts– Plantar warts
Molluscum contagiosum
• Smooth waxy nodules on the face, trunk, and limbs
• May be indented in the middle• May contain milky fluid• Common in children• Most often causes nodules on the face, arms,
legs, and trunk in children; mostly in genital areas in adults
Large Pustular Skin Lesions
• Leishmaniasis• Cutaneous anthrax
Leishmaniasis
• Zoonosis transmitted by female sand flies• Several different forms, depending on the
species of Leishmania that is involved– Cutaneous leishmaniasis– Espundia– Systemic leishmaniasis
Cutaneous Anthrax
• Most common and least dangerous version of infection with Bacillus anthracis
• Caused by endospores entering the skin through small cuts or abrasions
• Papule that becomes increasingly necrotic then ruptures to form a black eschar
Ringworm (Cutaneous Mycoses)
• Dermatophytes• Confined to the nonliving epidermal tissues
and their derivatives• Different names all beginning with the word
tinea
Superficial Mycoses
• Involve the outer epidermal surface• Ordinarily innocuous infections with cosmetic
rather than inflammatory effects• Tinea versicolor caused by Malassezia furfur
18.7 Eye Diseases Caused by Microorganisms
• Conjunctivitis– Infection of the conjunctiva– Fairly common– Can be caused by specific microorganisms,
contaminants, or accidental inoculation of the eye– Inflammation and discharge
• Bacterial infections- milky discharge• Viral infections- clear exudate
Figure 18.21
Trachoma• Chronic Chlamydia trachomatis infection of the
epithelial cells of the eye• Major cause of blindness in certain parts of the
world• First signs of infection- mild conjunctival
discharge and slight inflammation of the conjunctiva
• Followed by marked infiltration of lymphocytes and macrophages
• As these cells build up, they impart a pebbled appearance to the inner aspect of the upper eyelid
• Eventually, pannus occurs
Figure 18.22
Keratitis
• More serious infection than conjunctivitis• Invasion of deeper eye tissues occurs, can lead
to complete corneal destruction• Any microorganism can cause this condition• One of the more common causes: herpes
simplex virus• Preliminary symptoms: gritty feeling in the
eye, conjunctivitis, sharp pain, and sensitivity to light
River Blindness
• Chronic parasitic (helminthic) infection• Onchocerca volvulus transmitted by black flies• The worms eventually invade the entire eye,
producing inflammation and permanent damage to the retina and optic nerve