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Metabolic Testing – How to Use Testing to Treat a Wide Variety of Diseases
Dr. Mark Schauss – Lab Interpretation LLC
How I Choose Lab Tests
• People ask me about how I go about determining whether a test is valuable or not.
• Above all, it must have clinical relevance.
– If Aunt Martha comes in complaining of fatigue and the test I use doesn’t address this issue, there is no reason to run it.
• If the results change the way the patient is treated, then it may be valuable.
– This is utilizing the concept of biochemical individuality
How to Choose Lab Tests
• Does the test and the use of the results have scientific backing.
– In the case of Fatty Acids, targeting changes based on those results with specific fatty acids have not been shown to be effective.
• Ordering the fewest number of tests to get the maximum benefit.
• Preserving patient cash while increasing clinical success.
How I Choose Lab Tests
• Measuring an item in the blood or within a cell and applying a reference range to it may not reveal anything about the functionality of said item.
• Say two people do a test to measure the amount of magnesium in their cells.
• The reference range is 10 – 50 with a mid point of 30.
• Both people get a 30 yet person A is magnesium deficient and person B is not.
• How is this possible?
How I Choose Lab Tests
• When we do a functional test, we can look at the level of Ethanololamine in a Plasma Amino Acid test.
• It is a strong marker for the presence of a functional magnesium deficiency as well as giving us clues as to the production of acetylcholine.
• If person A shows up for a number of functional magnesium deficiencies than maybe the level of magnesium present in the sample of their cells may not be adequate due to genetic or environmental reasons.
How I Choose Lab Tests
• Person B may not need as much magnesium to function as efficiently compared to Person A.
• In order to get the best clinical outcomes, I look at the test in a true functional way.
• A problem I see with some labs is the agendizing of interpretations.
• They begin with a premise and will stick with that in spite of a preponderance of evidence to the contrary.
How I Choose Lab Tests• The problem arises when a lab takes a position on
the meaning of a variable and will not change the stance.
• p-Hydroxybenzoate, measured in urine organic acid tests, is used as a marker for paraben exposure.
• Ye, X., A. Bishop, et al. (2006). "Parabens as Urinary Biomarkers of Exposure in Humans." Environmental Health Perspectives 114(12): 1843-1846.
• Pugazhendhi, D., G. Pope, et al. (2005). "Oestrogenic activity of p-hydroxybenozic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines." Journal of Applied Toxicology 25: 301-309.
• Yet a number of labs sidestep the evidence and stick by their definition as strictly a marker for dysbiosis which may or may not be accurate.
How I Choose Lab Tests
• Some labs go so far as to interpret data in a way that has already been shown to be false yet hold steady because of their dogmatic views.
• Citramalate, Tartarate and Arabinose have been claimed to be markers for yeast yet there is powerful evidence to the contrary.
• There is a lab that continues to make the claim leading to countless people being treated with anti-fungals when there may be no need.
• Interpreting lab data is not an emotional issue, it must stay strictly scientific.
How I Choose Lab Tests• So why do children with autism improve using anti-
fungals if yeast is not so prevalent?• Many children with autism have upregulated Phase
I detoxification pathways and down regulated Phase II.
• The intermediary chemicals created in Phase I are more neurologically toxic than the original chemical, especially with petrochemical solvents.
• Anti-fungal drugs down regulate Phase I which allows Phase II to catch up.
• This is also why they do so poorly after removing the drugs.
• Improving Phase II through the use of amino acids such as Glycine will help upregulate Phase II.
How I Choose Lab Tests
• Lab competence is critical.
• I typically visit the lab, talk to their lab directors and talk to practitioners about their experiences.
• In an interview in Lab Interpretation LLC’s CD series, Laboratory Medical Update, I talked to Mark Newman, Assistant Lab Director for ZRT Labs about this issue.
• In my opinion, lab competency is one of the most important problems in our industry.
How I Choose Lab Tests
• I have seen lab results that made me believe that the lab used a random number generator to come up with the results.
• If the results cannot be trusted, what good is the interpretation?
• I will be starting a lab competency program this fall and will have a signup sheet for anyone interested in being involved and being kept abreast of the results.
Why Another Lecture About Lab Tests
• Albert Einstein once said when told his final exam he had given his students was the same as last years
• “True, but this year the answers are different.”• In laboratory testing, we learn new things from new
research every day. • We find new ways of testing, new results we can
interpret and better techniques of testing things we already know about.
• We also find new meanings about results causing paradigm shifts in treatment protocols.
Important Tidbits of Information• An example of a new interpretation for a pair of
well known test variables.• Vanilmandelic acid is the main metabolite of
catecholamines and Homovannilic acid is the main dopamine metabolite are both urinary metabolites .
• Vanilmandelate is related to phenylalanine and homovanillate to tyrosine.
• A few labs use these two to recommend the appropriate amino acid complex as well as the use of these two amino acids alone.
• This may be contraindicated because of newer research that has come to light.
Important Tidbits of Information• According to research, both of these variables
being elevated in urine have been correlated to environmental toxins such as heavy metals and petrochemical solvents and pesticides.
• de Burbure, C., J. Buchet, et al. (2006). "Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels." Environmental Health Persepectives 114(4): 584-590.
• Extremely elevated levels of these two metabolites may be indicative of tumor growth and possibly the onset of a myocardial injury.
• Toxins are implicated in a number of cancers so here may be one of the early warning flags before the disease presents itself.
Reference Ranges
• Labs typically run a number of tests on a wide variety of people in order to determine the reference range for a result.
• The range is where 95% of the test subjects results are.
• In some cases the reference range is overwritten by the medical director in order to propose a new definition of healthy.
• There are significant problems with these two scenarios.
Reference Ranges• In the case of the 95%, there is a problem
when the population is not healthy.• This is the case with Ultra-Sensitive Thyroid
Stimulating Hormone (TSH).• The typical lab range is .5 – 5.5 uIU/mL.• Unfortunately, an estimated 25-30% (it could
be higher) of the population is hypothyroid and fall into this range.
• Research has suggested that the proper reference range for TSH should be 1.1 – 2.5.
• This is the range we use in the LabAssist™ Reports.
Reference Ranges• In the other scenario, medical bias comes into play.• In a number of labs I have seen, the reference
range for Total Cholesterol is 0 – 199 mg/dL.• According to Bernard Statland, MD PhD, a world
renowed clinical pathologist states in his book Clinical Decision Levels for Lab Tests, when discussing a Cholesterol of 90 mg/dL or below “Values below this level are often associated with severe liver insufficiency.”
• So a person is in the reference range can be deathly ill as often times the prognosis for people at that level is “poor”.
Reference Ranges• The journal Circulation has an editorial that pointed
out the risks for many diseases goes up when Total Cholesterol is below 160 mg/dL.– Hulley, S., J. Walsh, et al. (1992). "Health Policy on Blood
Cholesterol: Time to Change Directions." Circulation 86(4): 1026-1029.
• The pressure put upon the editorial staff of Circulation by the pharmaceutical industry was immense for obvious reasons.
• Within the alternative supplement industry, there is a great deal of marketing money put into to the lowering of cholesterol paradigm despite evidence that it may not be beneficial in the prevention of coronary heart disease.
Toxicity Issues• In 2005 the CDC did a survey across America
where the average citizen had the presence of 148 chemicals in their blood. The report is 475 pages long.– Third National Report of Human Exposure to Environmental
Chemicals, Centers for Disease Control and Prevention 2005. www.cdc.gov/exposurereport/pdf/thirdreport.pdf
• One line in the report struck me for different reasons than it might strike others.
• Under Public Health Uses of the Report it states “To establish reference ranges that can be used by physicians and scientists to determine whether a person or group has an unusually high exposure.”
Toxicity Issues• As we know with laboratory testing, often
times reference ranges are skewed due to an abnormal population. Case in point TSH levels.
• This report makes it so that it will be used to allow for an “acceptable level” of toxicity for each of you and your patients.
• Some chemicals have an effect at low levels only.
• Polymorphisms in genes coding for metabolizing enzymes contribute to interindividual variability and may vary by more than 50-fold in humans (Guengerich et al. 1991).
Toxicity Issues• What is a poison for you may not be for me.• According to research done by the EPA on
Bisphenol A (BPA), they only looked at the changes to the weight of rat brains to determine toxicity levels.
• Some studies found changes in rodents' reproductive organs and brains at doses as low as 0.002 mg per kilogram of body weight per day.
• is just one-25,000th the dose that the EPA said was the lowest exposure having an observable adverse effect.
Toxicity Issues
• Newer research into the subtle effects of BPA on hormone levels indicates that far lower doses can have profound effects on the development of human fetuses and on adult health, especially women.
• While I believe there is an enormous benefit in testing people for hormone levels, I believe it is more important to test for endocrine disrupting chemicals that can affect hormone balance.
Toxicity Issues• If the findings that chemicals like Bisphenol A (BPA)
are found in the drinking water, house dust, and ambient air are true and at tiny levels they can affect estrogen receptors think of the types of cancers our children will have.
• In the 1950’s a woman’s lifetime risk of breast cancer was 1 in 22.
• Today it is 1 in 7.• It is not a genetic epidemic, it is environmental, it is
due to endocrine disruption.• BPA is worth $100 million an hour.• Banning it will take enormous guts.• Becoming good detoxifiers forever is therefore
critical.
Toxicity Issues• If you have a person that has done a saliva
hormone test and noticed that their cortisol levels do not go down through the day as expected the mechanism may be toxic in nature.
• In a study published in EHP February 2008, Gump et al showed that lead levels, even low ones below 10 μg/dL can alter corticosteroid levels and interfere with heightened reactivity to acute stress.
• Gump, B., P. Stewart, et al. (2008). "Low-level prenatal and postnatal blood lead exposure and adrenocortical responses to acute stress in children." Environmental Health Perspectives 116(2): 249-55.
• The higher lead levels in big cities like New York may explain the higher stress readings of inhabitants.
Toxicity, Is It In Us?• When the topic of toxicity is discussed, we
should no longer wonder whether our patient is toxic or not, but whether they are good excretors of toxins.
• This is especially true when dealing with petrochemical solvents as well as heavy metals.
• Other toxins like the byproducts of bacterial, parasitic and viral metabolism should also be monitored.
• The toxicity of stress is another issue that should be looked at holistically.
Toxicity Is It In Us?
• Detoxification should be thought of as a three-step process.
• First step is to identify the toxins (never assume there is only one) and begin an individualized detoxification protocol.
• This is where you determine the patient’s ability to naturally detoxify, support whatever phase of detoxification is efficient (if any) and bolster the phase that is inefficient in an individualized manner.
Toxicity Is It In Us?
• The second step, the part I feel is most important is to identify the source of the toxicity.
• If phthalates are the problem, look into the sources like cosmetics, air fresheners, perfumes and colognes, microwaving of plastics, dental retainers, etc…
• If it is stress, look into their lifestyles, behaviors, home life, and their past.
• Have them do an inventory of their environment to see where the toxins are and have them work on eliminating them.
Toxicity Is It In Us?
• The third step may be the hardest to convey.
• We no longer live in a world where “living clean” makes you free of toxic exposure.
• Eating organic, making sure you avoid toxicity in your home and work area is important but it does not keep you safe.
• We live in a toxic world.
• Because of this concept, we need to become efficient excretors of toxins for life.
Toxicity Is It In Us?
• People need to have tools to become efficient excretors and they need to do this on a daily basis.
• All of us, need to practice this on ourselves before we practice it on our patients.
• Educating the patient that this is a life long change that they need to commit to is critical to their ability to achieve victory over this toxic world.
• Turning ones face to the onslaught of toxins and denying it is an invitation to disease, morbidity and eventually mortality.
Toxicity Testing
• When dealing with endocrine disruption disorders ranging from diabetes to hypothyroidism there are two essential tests to run.
• An Environmental Pollutants Biomarker test and a Whole Blood Elements.
• Both are available through LabAssist.
• The first is run by US Biotek and the second through Doctor’s Data.
Toxicity Testing
• Finding out the excretion pattern in individuals with solvent toxicity is critical in determining exposure and subsequently, detoxification protocols.
• Finding out heavy metal levels as well as trace mineral competency is also highly beneficial in treating the causative factors in endocrine disruption.
Toxicity
• A normal mammalian response to toxicity is to lower metabolism.
• The increased incidence of depressed basal temperatures in patients can be directly related to the increased levels of toxicity.
• In a number of cases we have noticed a distinct improvement in basal temperature through proper detoxification.
Important Tidbits of Information
• When comparing lab results from one test to another, timing is everything.
• In the case of Cholesterol, readings tend to be higher in the fall and winter than the spring and summer.
• The difference can be as much as 20%.
• If you wanted to produce a study on the effect of your drug or supplement on cholesterol levels, when would you start the study and when would you follow up the test?
Important Tidbits of Information
• If the person has had a traumatic episode recently such as surgery, accident, death in the family, do not run an organic acid in urine test.
• The results of this test would be highly skewed and may not accurately reflect the persons true metabolic state.
• A 1-2 month rest period is suggested to let the system “settle down”.
Important Tidbits of Information• If a child is traumatized because of a blood
draw, the results will be skewed and will not be reflective of their true metabolic state.
• Liver enzymes, electrolytes and hematology will all be negatively affected by a traumatic blood draw.
• An amino acid plasma test needs a 12-14 hour fast prior to the test for accuracy.
• A comprehensive blood chemistry needs 8 hours.
• Urinary Organic Acids need dietary restrictions to be accurate.
Aging
• One of the most important issues in today’s society is aging.
• With our aging population, a lot of people want to know how to slow down the process.
• Here is what we do know:
– Aging is about oxidation
• The use of anti-oxidants do not seem to slow down the aging process all that much.
Aging
• You can cut back the speed at which you age by cutting back on the amount of food you eat drastically.–Numerous studies suggest that it is
the quantity of food that is the key. When you eat very little the cells last longer. Or is that the real mechanism???
Aging• The real key to living longer is reigning in
inflammation.• In an excellent, but hard read, Professor
Caleb E. Finch wrote the book – The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans, 2007 Academic Press discusses the issue.
• Does the longevity research into low-calorie diets only mean that the low intake is the sole anti-aging driver?
• Another possibility is that when you restrict your diet, you avoid inflammatory foods.
Aging• The LEAP MRT Food Sensitivity test is a good way
to find out what foods increase the inflammatory response.
• By avoiding these foods, you can drastically reduce inflammation which is beneficial not just in slowing down the aging process but in a myriad of inflammatory diseases ranging from coronary heart disease, migraines, arthritis, irritable bowel syndrome, and any neurodegenerative disease.
• We know that inflammation can also affect the mitochondria so any time we can reduce inflammation we protect the mitochondria.
Aging, Oxidation and Inflammation
• We know that chronic infections cause oxidative stress.
• Wen, J., P. Yachelini, et al. (2006). "Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients." Free Radical Biology and Medicine 41(2): 270-6.
• Monitoring the patient using a Comprehensive Blood Chemistry is highly beneficial.
• The pattern in the differential of White Blood Cells is helpful in determining the type of infection.
• The test should always include Uric Acid which isn’t typically included.
Uric Acid• Uric Acid is one of the bodies natural
antioxidants.• Increased levels are typically caused by the
bodies need for antioxidant help. • It is known to scavenge peroxynitrate.• Multiple sclerosis patients have low Uric
Acid and high peroxynitrate.• Lower serum Uric Acid levels in MS patients
may represent a primary, constitutive loss of protection against Nitric Oxide.
• Stimulating xanathine oxidase through the use of molybdenum may be beneficial.
Inflammation and Infection• Neutrophils are typically indicative of a bacterial
infection but an increase of the absolute numbers can occur with inflammation.
• Eosinophils are typically seen in allergic responses but also in infestations of parasites.
• Basophils are rarely seen but when they are elevated it is indicative of an allergic response and correlates to elevated histamine in the blood.
• Monocytes, the largest of the white blood cells are phagocytic as they are viewed as scavengers but they also produce the antiviral agent interferon.
Inflammation and Infection
• Lymphocytes are a primary defense against viruses but they are also seen in the early and late stages of inflammation.
• Looking at the pattern of these cells both in percentages of the total and in absolute numbers can give you a very accurate picture of what is going on immunologically.
• With LabAssist™ we have already pre-programmed many of these patterns.
• Through that we have even been able to reveal a case of Psittacosis.
Infertility and Pregnancy
• At no time in human history has infertility reached such epidemic proportions.
• The blame clearly has to lie at the feet of our toxic environment.
• According to the Center for Disease Control’s National Survey of Family Growth the fastest growing segment of the population with “impaired fecundity (infertility) is women under the age of 25.”
Infertility and Pregnancy
• In the 1970’s, Danish researcher Niels Skakkebaek of the Copehagen University Hospital showed links between testicular cancer in adults and abnormalities in genital development.
• At 3 months, baby boys experience a surge of testosterone.
• In a study of 65 infants published in 2006, they discovered that the higher the level of phthalates, the greater the evidence of anti-androgenic hormonal activity.
Infertility and Pregnancy• Ana Soto of Tufts University School of
Medicine was studying the effect of estrogen on a breast cancer cell line.
• Much to her chagrin, the cancer cells were proliferating like crazy as if a bottle of estradiol had been dumped in them.
• Turns out, the tubes storing a component of the medium growing the cells had nonylphenol to improve impact resistance.
• The chemical, injected into rats, made the epithelial lining of the uterus proliferate – a sign of its being an estrogen.
Infertility and Pregnancy• I believe that for all people, male or female, it is
imperative to do an Environmental Pollutants Biomarker test.
• Phthalates, xylene, toluene, benzene, styrene, and dimethylbenzene are all developmentally toxic.
• Phthalates can damage male DNA in sperm.• It can also cause shortening of pregnancies by up
to two weeks and according to research full-term babies have markedly higher cognitive scores later in life (Larroque, et al, The Lancet, Vol 371, pg 823).
• Urinary markers of phthalates are vastly superior to serum.
– Hogberg, J., A. Hanberg, et al. (2008). "Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vunerable populations." Environmental Health Perspectives 116(3): 334-9.
Infertility and Pregnancy• For women, I would highly suggest doing two
additional tests aside from the EPP.• A Whole Blood Elements test from DDI would be #1
as quite often women trying unsuccessfully to have a child are very mineral deficient.
• Also, any toxic heavy metal load could decrease the chances for a healthy pregnancy.
• In the March 2008 EHP journal, researchers led by Leasure, et al, showed that gestational lead exposure produced permanent male-specific effects including an increase in obesity as well as motor deficit, and altered dopamine.
• The responses were dose-dependent.
Infertility and Pregnancy• Secondarily, a Plasma Amino Acid test often times
show broad deficiencies in both essential and conditionally essential amino acids.
• With women, there have been some issues with increased tryptophan and elevated serotonin (especially with 5-HTP) and an increase in miscarriages, dysmenorrhea and tubal spasms.
• With males, it may improve sperm viability.• In a study by Schacter in 1973, 4 grams of arginine
was used on 178 men and 111 had significant improvement, 21 moderate and only 25 showed no improvement in sperm motility and sperm counts.
Infertility and Pregnancy
• A urine iodine challenge may be another important test to do for pregnant women.
• In the autism pesticide study (Roberts, et al, 2007 EHP), iodine deficiency may be the mechanism by which the incidence of autism rose to exposed mothers.
• Since many environmental toxins affect the thyroid and the lack of iodine can adversely affect the fetus, this is another very important test to run.
Autism• Urinary porphyrin testing is the latest rage.• It is theoretically useful if the specimen is handled
correctly.• There in lies the rub.
– Porphyrin’s are highly light and air sensitive.– Pee into a bucket with a fluorescent light and
half the analyte is gone.– Shaking instead of gently rocking the specimen
can cause depletion of the porphyrin analyte.• There is a very high incidence of false negatives with
this test.• Even with proper handling, the false negative rate
reduces clinical utility.
Autism• Urine heavy metal challenge tests are also
commonly used with children with autism.• It’s clinical utility is questionable.• The risk of developing side-effects due to the
use of a chelating substance is substantial.• It does not indicate the burden and/or the
disruption of biochemical pathways due to mercury or other heavy metals.
• A hair elements test, using the counting method developed by Dr. Andrew Cutler and spelled out in his books Hair Test Interpretation and Amalgam Illness (available at www.noamalgam.com) is safer and superior.
Autism
• According to the data from the DAN website, chelation therapy has a very high positive outcome with a low negative and relatively low no effect rate.
• http://www.autism.com/treatable/form34qr.htm
• Out of 803 cases reported the positive response rate was 74% with negative results being at 3% and no response being the lowest of all treatments at 23%.
Autism• I see a high percentage of autistic children,
especially boys with high urinary phthalate levels.• They also often times have other solvents such as
xylene, toluene, styrene, and benzene.• Detoxifying these ubiquitous chemicals seems to
lower many of the common traits such as stimming, head banging and hand flapping.
• This may be due to the upregulation of Phase II detoxification from the detoxification protocols reported in the LabAssist Interpretive Reports.
Autism
• A Plasma, Blood Spot or Urine Amino Acid test would be beneficial in assessing these important builders of neurotransmitters.
• LabAssistTM has developed a method to customize the My Aminoplex based on a Plasma or Blood Spot Amino Acid test.
• We see a number of children with autism with dramatically abnormal amino acid profiles.
• Taurine is typically low and autistic children benefit greatly from its supplementation.
Asthma• In numerous studies, pollution has been a
driving force in the increase of asthma cases, especially pediatric.
• Many of the variables found in the Environmental Pollutants Biomarker test from US Biotek, have been shown to increase asthma rates.
• Diesel fuel driven trucks and cars release benzene, which is known to cause inflammatory responses in the lungs as well as reduce oxygen carried by red blood cells.
• Inner city children, exposed to petrochemicals have some of the highest rates of asthma. – Wu, F. and T. Takaro (2007). "Childhood asthma and
environmental interventions." Environmental Health Perspectives 113(6): 971-5.
Asthma• The driving force behind the dramatic
increases in asthma cannot be explained by a genetic component.
• The evidence is clear.• Environmental pollution is the reason for the
increases.• Xylene can irritate the lungs.• Toluene can cause a disruption of the
hypothalamus which has been linked to an increase in asthmatic attacks.
– Moron, L., J. Pascual, et al. (2004). "Toluene alters appetite, NPY, and galanin immunostaining in the rat hypothalamus." Journal of Neurotoxicology and Teratology 26(2): 195-200.
– Nagata, S, Role of anterior hypothalamus on asthma, International Congress Series Volume 1287, April 2006, Pages 256-259 Psychosomatic Medicine - Proceedings of the 18th World Congress on Psychosomatic Medicine, held in Kobe, Japan, between 21 and 26 August 2005
Asthma
• Phthalates, found in air fresheners, new car smell and many plastics have been implicated in asthma.– Bornehag, C., J. Sundell, et al. (2004). "The Association between
Asthma and Allergic Symptoms in Children an Phthalates in House Dust: A Nested Case-Control Study." Environmental Health Persepectives 112(14): 1393-1397.
– Kolarik, B., K. Naydenov, et al. (2008). "The association between phthalates in dust and allergic diseases among Bulgarian children." Environmental Health Perspectives 116(1): 98-103.
• Assessing urinary output of these solvents and following the recommended protocols may be helpful in working with asthmatics.
Asthma
• Air pollution and stress interact to create a predictive clinical outcome in asthma.– Chen, E., H. Schreier, et al. (2008). "Chronic traffic-related air pollution
and stress interact to predict biologic and clinical outcomes in asthma." Environmental Health Perspectives 116(7): 970-5.
• In my preaching to the choir statement of the day, asthma is not a deficiency of steroids.
• It is clearly related in many cases to an increase of pollution and toxicity in both children and adults, especially women.
Asthma• Adult onset asthma is often linked to
hypothyroidism.• The Nurses’ Health Study done at Harvard
found that women taking postmenopausal hormones were 50% more likely to develop adult-onset asthma due to higher estrogen.
• This may explain why girls have much higher rates of asthma than boys.
• Often times, asthmatics will have abnormal electrolyte and thyroid panels.
• Using a balanced electrolyte like Peltier often times improves breathing but should not be thought of as a treatment for acute episodes.
• A comprehensive blood chemistry is essential in the treatment of asthma.
Type II Diabetes• With any diabetic, running a comprehensive
blood chemistry should be a given.• Monitoring blood sugar, triglycerides,
cholesterol with LDL and HDL are critical to any dietary intervention.
• Electrolyte depletion, particularly sodium, potassium, magnesium, calcium, bicarbonates and chlorides are often seen and need to be addressed if deficient.
• Some of the markers for oxidation like uric acid are also seen along with elevated fibrinogen.
Type II Diabetes
• Here is the pattern often seen with people with Type II diabetes:
– Elevated: Alkaline Phosphatase, Basophils, Cholesterol, Creatinine, Fibrinogen, Glucose, GGT, Hemoglobin A1c, LDL, Triglycerides, BUN, and Uric Acid
– Decreased: Albumin, CO2, Calcium, Chloride, HDL, Iron, Phosphorus, Potassium, and Sodium.
Type II Diabetes• Plasma amino acids can also help with a
support protocol for people with diabetes.• Cysteine and Taurine are beneficial in
preventing kidney failure.• Taurine is helpful in counteracting oxidative
stress commonly found in diabetics.• It should be used with caution as it can
lower blood sugar due to its action of potentiating insulin.
• GABA is thought to increase insulin’s effect and the use of 2-4 grams can significantly decrease blood sugar.
Type II Diabetes• An Environmental Pollutants Biomarker test
is also very helpful if the person has been exposed to high levels of a number of toxins.
• Phthalates have been shown to affect insulin resistance.– Stahlhut, R., E. Wijngaarden, et al. (2007). "Concentrations of
Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males." Environmental Health Perspectives 115(6): 876-82.
• Chemicals like toluene, xylene, benzene and styrene have been implicated in a wide array of endocrine disruption and blood sugar regulation.
Type II Diabetes• Urinary Organic Acids are a tertiary test to use
because it can help identify the following problems known to occur in diabetics:– Excessive Fatty Acid Oxidation– Carnitine Deficiencies– Keto-acidosis– Disordered Gluconeogenesis– Excessive Oxidative Stress– Intestinal Dysbiosis– B-Complex Competency– Liver Detox Dysfunction– Poor Energy Production
Type II Diabetes
• As with most disorders, inflammation is a key component in the progression and/or control of diabetes.
• Diet is critical.
• Assessing the foods that can trigger inflammatory reactions is important in helping your patient achieve optimal help.
• This is another good reason to utilize the LEAP MRT blood test.
Type II Diabetes• The LEAP MRT test is beneficial in order to
isolate those foods, regardless of their affect on blood sugar, that might induce an inflammatory response.
• Reducing this response will improve the quality of life of the diabetic since many of them have numerous other symptoms like arthritis.
• Drugs used to treat arthritis like anikinra (Kinemet) have been shown to help regulate blood sugar because of their effect on the cytokine IL-1 (interleukin-1).
Type II Diabetes• The immune system produces cytokines in response
to inflammation in the body. The cytokine, Interleuken-1 (IL-1) shows up in areas of inflammation, like in the joints or other places in the body. Anakinra blocks the production of interleukin-1. That's why it's used to treat arthritis.
• In diabetes, interleukin-1-beta is produced in the pancreas. High glucose levels appear to trigger the release of interleukin-1-beta. This not only reduces the function of beta cells in the pancreas, but can cause beta cells to self-destruct.
• This is why using LEAP MRT with diabetics may be highly beneficial.
Further Information
• I will be doing one and two-day seminars here in Colorado and around the country starting this fall through next spring.
• It will be covering 25 different disorders and the appropriate tests that would give the best clinical results.
• The course will also review actual cases.
• If you are interested, please see us this weekend at our booth to get on the list.
Contact Information
Dr. Mark Schauss, DBLab Interpretation LLC
18124 Wedge Parkway, Ste 432
Reno, NV 89511775-851-3337
www.labinterpretation.comwww.MarkSchauss.com
www.ToxicWorldBook.com
