May 2015 newsletter - Boston University Medical …2015/05/05 · electronic newsletter. David Coleman, M.D. Message from the Chairman Boston Medical Center/ Boston University School

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Colleagues,

As the academic year draws to a close, I wanted to extend my heartfelt thanks to the faculty and staff of the Department of Medicine for your support of one another through a stressful period. Your diligence and extra efforts to transition to the ambulatory version of EPIC have been remarkable and materially contributed to the success of the conversion. Obviously, EMR transitions are very disruptive and ultimately depend on the professionalism and commitment of the clinicians and IT staff. We are so appreciative of your efforts! The past several months have also been stressful because of the uncertainty surrounding the potential BMC-Tufts merger. I hope we can work together with BMC to pivot from the merger discussions to a renewed focus on improving the experience of our patients at BMC! Our department’s research faculty continue to achieve remarkable success in securing grant funding. For the first nine months of AY 15, we have nearly double the research funding of AY 15! More broadly across the department, our research faculty covered over 85% of their salary/fringe costs of their research effort in AY 15. Although a number of grant applications are outstanding, we are projecting that 80% of the salary/fringe cost of the faculty effort in research will be covered by grants in AY 16 based on current secure funding. These figures compare very favorably with other clinical and basic science departments across the country! The recent renewal of the Framingham Heart Study contract, under the direction of Dr. Vasan Ramachandran, and the Nephrology T32 Training Grant, under Dr. David Salant, are particularly important achievements. Congratulations! Thank you very much for your efforts in supporting excellence and one another across the department! I hope you enjoy this addition of the electronic newsletter.

David Coleman, M.D.

Message from the Chairman

Boston Medical Center/ Boston University School of Medicine

Department of Medicine Newsletter

May 2015 Department of Medicine Newsletter

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CONGRATULATIONS


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David Center, MD, Professor of Medicine and Biochemistry and associate provost for translational research, was elected under the Section on Medical Sciences for his “contributions to the field of immunology, particularly for the discovery of the first human (IL-16) and virus-derived (HIV-1 gp120) lymphocyte chemotactic factors.”

David Center, MD

David Salant, MD

Katya Ravid, PhD

The following Faculty members have been named Fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. AAAS is the publisher of the journals Science, Science Translational Medicine, and Science Signaling. It began electing Fellows in 1874 in recognition of their scientifically or socially distinguished efforts to advance science or its applications. This year’s 401 new Fellows will be recognized at the Fellows Forum at the AAAS annual meeting in San Jose, California, on February 14, 2015.

Katya Ravid, PhD, Professor of Medicine and Biochemistry and founding director of the Evans Center for Interdisciplinary Biomedical Research, was elected under the Section on Medical Sciences for “pursuing interdisciplinary research, and outstandingly combining the fields of hematology and vascular biology, leading to the discovery of transcriptional and cell cycle signatures that govern polyploidy during megakaryocyte/platelet development.”

David Salant, MD, Professor of Medicine and Pathology and Laboratory Medicine and chief of the renal section at Boston Medical Center, was elected under the Section on Medical Sciences for his “contributions to the field of immunological kidney diseases, particularly for discovering that the anti-phospholipase A2 receptor is the major autoantigen in human membranous nephropathy.”

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CONGRATULATIONS


Page 3

The Massachusetts Life Sciences Center (MLSC) has awarded $1.74 million to Boston University’s Center for Regenerative Medicine (CReM) to help build a new lung regeneration facility. The new facility, to be housed at CReM on the Medical Campus, will bring together academic and industry scientists from across the state to apply stem cell biology advances to developing new treatments for cystic fibrosis and other lung diseases.

The goal of the new lung regeneration facility is the clinical application of recent discoveries in stem cell research that have been led by CReM codirectors Darrell Kotton, MD a MED professor of medicine and pathology, and Gustavo Mostoslavsky, MD, PhD and George Murphy,PhD both MED

assistant professors of medicine.

Kotton says he was honored to receive the award, which will help build the new facility for the Lung Regeneration Initiative. “This facility will enable scale-up of the production, banking, and national sharing of pluripotent stem cells made by reprogramming blood specimens from patients who suffer from lung diseases,” he says. “Most importantly, the proposed facility will allow both academic and industry scientists from across the state to focus on the goal of achieving personalized treatment applications based on individualized drug tests performed in culture dishes using lung cells made from each patient’s banked stem cells. We believe this approach is desperately needed to develop new treatments for the many lung diseases for which there are currently ineffective treatment options. This is an important and exciting step towards our research community’s ultimate goal of accomplishing successful lung repair and regeneration in our patients.”

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CONGRATULATIONS


Page 4

Karen Lasser, MD, MPH has been appointed to the JGIM editorial board for the 2015-2018 tenure.

Megan Gerber, MD, Medical Director of Women’s Health, Primary Care at the VA, is the recipient of the 2014 David Littman Award. Each year nominations are solicited for a physician who has shown excellence in clinical care and teaching. Dr. Gerber exemplifies these qualities and is a great asset to the Primary Care service and Medical Center with her extensive knowledge and commitment to improving the care of women. She continues in her role as Fellowship director and has built a strong clinical educational experience and mentors fellows in developing research interests.

David Salant, MD, Professor of Medicine and Pathology and Laboratory Medicine, was awarded the 2015 Donald W. Seldin award from the National Kidney Foundation. The Donald W. Seldin award recognizes excellence in clinical nephrology in the tradition of one of the foremost teachers and researchers in the field, Dr. Donald W. Seldin. Supported by grants from the National Institutes of Health, he has conducted extensive research on immune disorders of the kidneys. Dr. Salant’s work has led to breakthroughs in identifying and treating membranous nephropathy, specifically he helped to identify a protein called PLA2R that is crucial to understanding the development of the disease. David Salant, MD

Karen Lasser, MD, MPH

Megan Gerber, MD

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CONGRATULATIONS


Page 5

Dan Alford, MD, MPH has been awarded the 2014 HIDTA Award for Outstanding Prevention Effort from the White House Office of National Drug Control Policy (ONDCP) for Boston University School of Medicine’s SCOPE of Pain Program. Dr. Alford received a letter from Murray Kopelow, MD, MS (Comm), FRCPC, President and CEO of the ACCME who stated “I applaud your commitment to addressing the prescription drug abuse epidemic through continuing education. Your program has demonstrated that accredited CE can contribute—as a strategic partner - to the government’s public health initiatives.

Richard Saitz, MD, MPH was chosen as the winner of the 2015 Best Published Research Paper of the Year Award from the Society of General Internal Medicine. The goal of this award is to highlight the outstanding scholarship of the SGIM members. The award is based on contribution the paper has made to generalist research. Dr. Saitz’s paper was selected as the most outstanding of the nominated papers. Saitz was lead author on a study published in Journal of the American Medical Association that cast doubts on the effectiveness of brief doctor’s–office interventions in stemming unhealthy drug use among patients. The paper noted that while the practice of screenings and interventions has received substantial support, there has

been little analysis of its efficacy.

Andrew Henderson, PhD has been named Chair for the AMCB AIDS Molecular and Cellular Biology Study Section for NIH. The AIDS Molecular and Cellular Biology [AMCB] Study Section reviews applications concerned with the molecular biology, cellular biology, structural biology, virology and genetics of HIV and related lentiviruses involving biochemical, pathophysiological and structural approaches. Emphasis is on molecular structure-

function approaches to elucidating virus and host

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PROMOTIONS


Page 6

Devin Mann, MD, MS

Promotion to Associate Professor Preventative Medicine

Lee Quinton, PhD

Promotion to Associate Professor Pulmonary Medicine

Amresh Hanchate, PhD

Promotion to Associate Professor General Internal Medicine

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Jose Cacicedo, PhD

Promotion to Assistant Professor Endocrinology

Romy Christmann de Souza, MD

Promotion to Assistant Professor Rheumatology

PROMOTIONS

Naomi Ko, MD, MPH

Promotion to Assistant Professor Hematology/Oncology


Mi Jeong Lee, PhD


Marc Liesa Roig, PhD


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The Awards Committee is now soliciting nominations for its five annual departmental awards.

1. The DOM Clinical Excellence Award was established in 2014 to recognize and celebrate outstanding clinical

prowess manifested in expert clinical skills, extensive medical knowledge and exemplary doctor-patient relationships. It is

intended to acknowledge the value of clinical medicine and honors clinical role models among the faculty.

a. Who can nominate: Residents, fellows, and faculty members can nominate for this award.

b. Who can be nominated: Nominees must be faculty members with at least five years of experience at BU.

Who is ineligible: Any past winner

2. The Robert Dawson Evans Faculty Special Recognition Teaching Award was established in 1998 to recognize

faculty members who make extraordinary contributions to the educational mission of our department over time. Winners

of the award may demonstrate leadership, creativity, or dedication to educating any level of trainees or peers.


b. Who can be nominated: Nominees must be faculty members with at least five years of experience at BU.

Who is ineligible: Any past winner

3. The Research Mentoring Award was first given in 2007. It recognizes members of the Department of Medicine

who have mentored trainees and faculty in the technical and scholarly skills required for a successful career in laboratory,

clinical, or population-based investigation.


b. Who can be nominated: Faculty who have been on staff for at least five years.

Who is ineligible: Past winners

4. The Outstanding Citizenship Award was first awarded in 2009. It acknowledges faculty members who help estab-

lish a healthy, enjoyable work environment and who solve problems for their whole section.

a. Who can nominate: Only a member of the faculty can submit a nomination for this award.

b. Who can be nominated: Nominees can be of any rank and have staff appointments of any duration.

Who is ineligible: Past winners

Nominations for Annual Awards Requested

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5. The Junior Faculty Mentoring Award, established in 2009, recognizes excellence in mentoring by a

junior faculty member. Winners of the award contribute to the successful career development of peers

and trainees.


b. Who can be nominated: Faculty members with an academic rank of Instructor or Assistant

Professor who have held a staff appointment at BU or elsewhere for no more than seven years.

c. Who is ineligible: Past winners

6. The Award for Clinical Quality Improvement. This is intended to be for work that resulted in improvements in the provision of clinical care.

Nominations will be accepted for individuals or teams. Individual Nominees must hold a faculty appointment in the Department Of Medicine. Teams that are nominated must include at least one DOM faculty member who played a prominent role in the work. Team nominations must include the name of a principle point of contact for the team.

Criteria the committee will use to judge the worthiness of the nomination will include: 1. The quality and outcome(s) of the project 2. The types and creativity of changes required to achieve improvement 3. Effort of staff required

4. Lessons learned

Other issues that will be considered include, but not required are: applicability of the findings to other units, generalizability outside the institution, scholarship produced, including presentations at meetings and traditional publications.

Nominations consist of a letter with a detailed justification of the nominee’s relevant contributions in the award

category. Please submit through the Faculty Development and Diversity website by May 31, 2015: http://

www.bumc.bu.edu/facdev-medicine/faculty-awards/submit-a-nomination/

Awards continued…..

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Faculty Development and Diversity

Congratulations to the DOM faculty accepted to the

2015-2016 Academy for Faculty Advancement!

Ambili Ramachandran, MD, MSc General Internal Medicine

Elizabeth Hu�on, MD General Internal Medicine

Joanna D’Affli , MD, MPH General Internal Medicine

Julia Xu, PhD Endocrinology

Markus Bachschmid, PhD Whitaker Cardiovascular Ins+tute (CVI)

Patrick Fleming, MD General Internal Medicine

Rebecca Mishuris, MD, MS, MPH General Internal Medicine

Rivka Ayalon, MD Nephrology

2015-2016 Education Pilot Grant Recipients

Julien Dedier, MD, MPH (PI) and

Sonia Ananthakrishnan, MD (Co-PI)

Project: Incorporating Clerkship Learning Objectives into the Third Year Internal Medicine Rotation: A structure for improved learning and feed-

back on ward teams

Ryan Chippendale, MD (PI) and

Laura Kaufman, DMD (Co-PI)

Project: Oral Health for Older Adults: Inter-professional training

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BMC GRANTS February-April


SECTION PI LAST

NAME PI FIRST

NAME PROJECT TITLE

PROJECT

TOTAL

COSTS PROJECT

END DATE

FUNDING

AGENCY

Cardiology Ruberg Rick

Cardiac Function as a mechanism for maladaptive brain aging (Supplement) $46,946 2/28/2015

Vanderbilt University Medical Center

CReM Murphy George

Targeting Edogenous Signaling Pathways to Amliorate Systemic Amyloidoses $95,105 6/30/2015

The Scripps Research Institute

Endocrinology, Diabetes and Nutrition Kim Dong

A Prospective , Multi-center Registry for Patients with Short Bowel Syndrome $36,226 1/31/2030

NPS Pharmaceuticals

General Internal Medicine

Paasche-

Orlow Michael National Health Literacy Mapping to Inform Healthcare Policy $35,542 4/30/2015

University of North Carolina

Endocrinology, Diabetes and Nutrition Fried Susan

Glucocorticoids & adipocyte function in human obesity $426,660 3/31/2020 NIH-NIDDK

General Internal Medicine Saitz Richard

Addressing Alcohol/HIV Consequences in Substance Dependence-Boston ARCH Cohort (Supplement) $173,589 8/31/2016 NIH-NIAAA

General Internal Medicine Kressin Nancy

Insurance Instability and Disparities in Chronic Disease Outcomes $143,756 5/31/2015 NIH-NIMHD

Hematology and Medical Oncology Hartshorn Kevan

A Randomized, Double-Blind, Phase 3 Study of the JAK 1/2 Inhibitor Ruxolitinib of Placebo in Comb@ $55,523 1/31/2017 Incyte Corporation

Hematology and Medical Oncology Seldin David

PRENOT: The Role of an Environmental Chemical Receptor in Development and Propagation of Cancer St.. $75,000 6/30/2016 Avon Foundation

Infectious Diseases Linas Benjamin

Economic Analysis of Rapid HIV and HCV Testing in Drug Abuse Treatment Programs $86,875 1/31/2016 NIH-NIDA

Cardiology Ruberg Rick

Serum Biomarker identification of cardiac amyloidosis in elderly African Americans $478,500 3/31/2017 NIH-NIA

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BMC GRANTS Continued


SECTION PI LAST

NAME PI FIRST

NAME PROJECT TITLE

PROJECT

TOTAL

COSTS PROJECT

END DATE FUNDING

AGENCY

Endocrinology, Diabetes and Nutrition Roy Sayon

Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy $2,175,000 3/31/2020 NIH-NEI

Gastroenterology Wali Ramesh

Towards Development of an in vitro Assay to Personalize Colonic Chemoprevention $174,000 3/31/2017 NIH-NCI

General Internal Medicine Pace Christine

Integrating Behavioral Health Services: Applying Lessons Learned at an Academic Safety-

Net Hospital $65,182 4/30/2016

Harvard Pilgrim Health Care (HPHC)

General Internal Medicine Lasser Karen

PRENOT:A Patient navigator-photovoice intervention targeting high risk Boston neighborhoods to impro $33,000 6/30/2015 NIH

Geriatrics Liu Christine

Encouraging Physical Activity and Improving Performance in Older Adults $13,180 9/30/2015 Tufts University

Hematology and Medical Oncology Hartshorn Kevan

Enhancing Collectin Mediated Defense Against Influenza $1,748,200 6/30/2019 NIH-NHLBI

Pulmonary, Allergy and Critical Care Wilson Andrew

Alpha-1 Antitrypsin Deficiency Adult Clinical and Genetic Linkage Study $216,163 8/31/2017

Alpha-1 Foundation

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BU GRANTS January—March


AWARD FUND CENTER PI AWARD TITLE SPONSOR PROJECT END

DATE

ADDITIONAL

FUNDS

THIS BUDGET

PERIOD

MED NATIONAL BIO

LAB KRAMNIK IGOR

NOVEL TB TREATMENT STRATE-

GY - OPTIMIZATION OF MACRO-

PHAGE RESPONSIVENESS TO

IFNY

NIH/NATIONAL INSTI-

TUTE OF ALLERGY &

INFE

02/28/2018 491,100.00

BIOMEDICAL GENETICS FARRER A LINDSAY

ALZHEIMER DISEASE GENETIC

ARCHITECTURE IN AFRICAN

AMERICANS

NIH/NATIONAL INSTI-

TUTE ON AGING 01/31/2020 652,832.00

BIOMEDICAL GENETICS SHERVA M RICHARD

GENETIC ARCHITECTURE OF

MEMORY AND EXECUTIVE

FUNCTIONING INALZHEIMER'S

DISEASE

UNIVERSITY OF

WASHINGTON 06/30/2015 26,796.00

CNTR MED--ARTHRITIS

CENTER MONACH A PAUL

VASCULITIS CLINICAL RESEARCH

CONSORTIUM

UNIVERSITY OF PENN-

SYLVANIA 08/31/2015 111,054.00

CNTR MED--

PULMONARY CENTER O'CONNOR T GEORGE

INNER CITY ASTHMA CONSORTI-

UM 3 (ICAC3)

UNIVERSITY OF WIS-

CONSIN 07/31/2015 797,941.00

CNTR MED--

PULMONARY CENTER O'CONNOR T GEORGE

TRANSCRIPTOMIC AND EPIGE-

NETIC SIGNATURES OF TOBACCO

EXPOSURE

AMERICAN HEART

ASSOCIATION 01/31/2017 250,000.00

CNTR MED--WHITAKER

CARDIO INST HERRERA M VICTORIA L

DECREASING STROKE RISK BY

RESTORING MICROVASCULAR

REPAIR

ELLISON FOUNDA-

TION 01/31/2016 200,000.00

CNTR MED--WHITAKER

CARDIO INST RAVID KATYA

TRAINING PROGRAM IN CARDI-

OVASCULAR BIOLOGY: PRE-

DOCTORAL

NIH/NATIONAL

HEART, LUNG, AND

BLOOD INST

11/30/2019 153,858.00

CNTR MED--WHITAKER

CARDIO INST RAVID KATYA

NANOPLATFORMS FOR IMAG-

ING BONE MARROW FIBROSIS

MPN RESEARCH

FOUNDATION 09/30/2015 100,000.00

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BU GRANTS Continued


AWARD FUND CENTER PI AWARD TITLE SPONSOR PROJECT END

DATE

ADDITIONAL

FUNDS

THIS BUDGET PE-

RIOD

CNTR--FRAMINGHAM

HEART STUDY RAMACHANDRAN VASAN

CARDIOVASCULAR GENOME

PHENOME STUDY

AMERICAN HEART

ASSOCIATION 06/30/2015 406,945.02

GASTROENTEROLOGY SINGH K SATISH

PERSONNEL AGREEMENT FOR

RESEARCH SERVICES OF ELADIO

RODRIGUEZ-DIAZ

VA BOSTON

HEALTHCARE SYSTEM 09/14/2015 40,564.04

GASTROENTEROLOGY SINGH K SATISH


RESEARCH SERVICES OF LISA

JEPEAL

VA BOSTON


GEN INTERNAL MED HERMOS A JOHN


RESEARCH SERVICES OF JOHN

HERMOS

VA BOSTON


GEN INTERNAL MED WHITE SUSAN

DEVELOPING HUMANISM IN A

NEW LONGITUDINAL INTEGRAT-

ED CLERKSHIP (DH-NLIC)

THE ARNOLD P. GOLD

FOUNDATION 07/31/2015 5,000.00

INST MD--

COMPUTATIONAL BIO-

MED

SPIRA AVRUM

CHARACTERISING THE TRAN-

SCRIPTOMIC ALTERATIONS AS-

SOCIATED WITH STRUCTURAL

PROGRESSION OF SMALL AIR-

WAY DISEASE

RESPIVERT, LTD. 11/30/2017 1,536,279.00

MED--PREVENTIVE

MED & EPIDEMIO RAMACHANDRAN VASAN

PROSPECTIVE META-ANALYSES

OF DRUG-GENE INTERACTIONS:

CHARGEGWAS CONSORTIUM

UNIVERSITY OF

WASHINGTON 05/31/2015 111,145.00

VASCULAR BIOLOGY SHAO DI

GLUTAREDOXIN-1 REGULATES

HEPATIC LIPID METABOLISM

IMPACTINGATHEROGENESIS

AMERICAN HEART

ASSOCIATION -

FOUNDERS AF

12/31/2016 47,000.00

Documents

May 2015 newsletter - Boston University Medical …2015/05/05 · electronic newsletter. David Coleman, M.D. Message from the Chairman Boston Medical Center/ Boston University School