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UNM College of PharmacyUNM College of PharmacyRadiopharmaceutical Sciences ProgramRadiopharmaceutical Sciences Program
New Mexico Center for Isotopes in MedicineNew Mexico Center for Isotopes in MedicineLANL Isotope Production ProgramLANL Isotope Production Program
UNM Group Members: UNM Group Members: Jeff Norenberg, PharmDJeff Norenberg, PharmD
Robert Atcher, PhD, MBA - UNM & LANLRobert Atcher, PhD, MBA - UNM & LANL
ANS Embedded Topical meetingANS Embedded Topical meetingJune 11, 2008June 11, 2008
Manpower Training Needs/Tiered Training Programs:Based upon NAS and other reports, to assess needs
for radiopharmacy, radiochemistry, and biomedical imaging scientists as a variety of training levels.
Discuss potential resources to support a PhD program in appropriate disciplines
Radiochemistry needs by role
Radioisotope ProductionReactor basedAccelerator based
Radiopharmaceutical ProductionCommercial SettingAcademic/Hospital CenterPharma
Radiopharmaceutical Research IndustryAcademic/Government
Radioisotope ProductionReactor based
Commercial entities Mo-99, Xe-133, I-131, I-125
Research entities University
MURR MITR TAMU UCD
National Laboratory ORNL INEEL
Radioisotope ProductionAccelerator based
Commercial sites Tl-201, In-111, Ga-67, I-123, Ge-68 PET radiopharmacy
F-18
Academic/Hospital Based F-18, C-11, O-15, N-13
National Laboratory High energy, high current accelerators
LANL, BNL RIA - site TBD
Radiopharmaceutical Production
Commercial setting-”Big RadioPharma”Perkin ElmerLantheusGESiemensCovidienDraximage IBABraccoNordion
Radiopharmaceutical Production
Commercial - startupsMIPCytogenTrace SciencesAMICAvid PharmaceuticalsCyclomedicaNorth American ScientificNuView
Radiopharmaceutical Production
Academic or Hospital settingRoutine synthesis
Cyclotron based Hot box
Custom or Research compounds Cyclotron based Custom configured hot box
Radiopharmaceutical Production
Traditional PharmaUtilize clinically proven radiopharmaceuticals
FDG, FLT,
Custom synthesis of drug candidates PK/PD studies
Radiopharmaceutical Research
IndustryMarket drivenFocus on demand and availabilityWaxes and wanes
AcademicResearch drivenUtilizes existing or “new” radionuclidesHas been steady till recently
DOE funding NIH funding
Radiopharmacy Manpower Needs~1,000 nuclear pharmacists within the USA450 nuclear pharmacies within the USA and growing
Commercial: CH NPS, Covidien, GE, IBA Molecular, PETNet, Triad Isotopes, Independents (UPPI)
Hospital/university-based
Nuclear pharmacy was the first specialty practice area recognized by American Pharmacists Association in 1975
First specialty recognized through Board Certification by the Board of Pharmaceutical Specialties 1978
The fastest growing area within nuclear pharmacy practice is in PET
Average starting salary for new graduates >$100,000, parity with hospital and specialty practice settings
Overview of UNM College of PharmacyRadiopharmaceutical Sciences Programs
Education, Research, and Clinical ServiceFirst University-based Radiopharmacy Education and
Training Program established in 1972First Commercial Nuclear Pharmacy 1973-1992DOE ANMI Nuclear Medicine Education Award for Graduate
Radiopharmacy Education $300,000 total, 2001-2004New Mexico Center for Isotopes in Medicine - UNM-Los
Alamos National Laboratoryestablished 12/2005
*ASHP accredited in 1982; **Plan I and II programs; ***Distance program w/UAMS
Date Program # #/yr
1972 Authorized Nuclear Pharmacist (ANP) 186 5.5
1977 to 1992 Post-graduate Radiopharmacy Residency* 31 3
1986 MS Pharmaceutical Sciences ** 31 1.5
1990 PhD Biomedical Sciences 3 NA
2001 Nuclear Education Online (NEO)*** ANP 317 30
2001 Authorized Users (Non-Pharmacist)*** 20 2
7/2004 Nuclear Pharmacy Technicians*** >300 20
7/2006 MD Nuclear Cardiology*** 157 80
5/2007 Department of Transportation*** 1817 500
5/2007 Radiation Safety*** 40 40
Authorized Nuclear Pharmacist Program1972 – Present186 Graduates – BS/PharmD + ANPProfessional Radiopharmacists
10 CFR 35.980APhA Syllabus for Nuclear Pharmacist Education and
Training250 Hours Didactic Education (NRC requires 200)
Physics and Instrumentation Radiochemistry Radiation Biology Radiation Safety Mathematics Clinical Clerkships (+50 hours to satisfy NMBOPs, and
others)500 Hours Structured, Supervised Experiential
Training
BPS Board Certification - 1978BCNP n=490
UNM Radiopharmaceutical Sciences Graduate Program
1986 – PresentMS Pharmaceutical Sciences (Radiopharmacy)31 GraduatesFocus on Applied and Translational ResearchPharmaceutical ScientistsAdvanced Clinical PractitionersDOE ANMI NMEA $300,000 2001-2004Linked with COP/BSGP PhD programs – 3
graduates
Status of Radiologic Pharmacy Education at Colleges of Pharamcy. Heske SM, Hladik WB, Laven DL, Kavula MP. AJPE 1996;60:152-161.
Status of Radiologic Pharmacy Education at Colleges of Pharmacy•1996•n=84•Part of core curriculum 46%•Separate required course 10%•>1 Elective course 46%•Overall 69% of all COPs offer•31% have zero•Mean 4.5 hours in core curriculum
UNM RadiopharmacyNuclear Pharmacy Residency1977 – 199231 GraduatesASHP AccreditedAdvanced Clinical
PracticePractice sites
UNM RadiopharmacyVAMC Regional
Medical Center
ASHP-Accredited Programs = 2SUNY Buffalo School of Pharmacy
Edward M. Bednarczyk, Pharm.D.(716) 645-2828E-mail: [email protected]
The National Capital Consortium/National Naval and Walter Reed Army Medical Centers Carol W. Labadie, COL, Pharm.D.
(202) 782-6072E-mail: [email protected]
ACCP-Accredited Programs = 0
Fellowships = 0
UNM MS Pharmaceutical Sciences (Radiopharmaceutical Sciences)SUGGESTED CURRICULUM1 PLAN II
Clinical Track 32 Semester hours
1st Year Nuclear Pharmacy Instrumentation (3) Nuclear Pharmacy Practice I (2) Radiopharmacology (3) Seminar (2) Health Physics/Radiation Biology (3) Radiopharmacy Management (2) Radiopharmaceutical Chemistry (2) Radiopharmaceutics (2) Elective(s) (0-6)
2nd Year Clinical Nuclear Medicine (1) Seminar (2) Thesis (3-6) Elective(s) (2-8) Hours 14
SUGGESTED CURRICULUM1 PLAN II
Basic Science Track 34 Semester hours
1st Year Nuclear Pharmacy Instrumentation (3) Radiopharmacology (3) Health Physics/Radiation Biology (3) Radiopharmaceutical Chemistry (2) Radiopharmaceutics (2) Seminar (2) Elective(s) (2-6)
2nd Year In Vivo/Vitro Radiotracer Procedures (2) Instrumentation and In Vitro Laboratory (2) Clinical Nuclear Medicine (1) Seminar (2) Thesis (6) Elective(s) (3-6)
Nuclear Education Online (NEO)www.nuclearonline.orgBest Resources for EducationExpert FacultyAdvantages of Distance
Education Anytime Anywhere Any pace Any base
Active Learning using Problem-Based Learning (PBL)
Consortium UAMS/UNM
Authorized Nuclear Pharmacist 2001 Goal 80 Students/Year 317 Graduates 2001-present
Authorized Users 75 Students 2001-present
Nuclear Pharmacy Technicians ~300 Students 7/2004-present
Nuclear Cardiology Physicians 157 Students 7/2006-present
DOT Training 1817 Students 6/2007-present
Radiation Safety 40 Students 5/2007-present
Curriculum Licensed to Universities U of Oklahoma, MUSC
UNM Education & Training Capabilities
NMCIM = UNM + LANL + NMSU Radiopharmaceuticals
• Discovery, Development, and Translation• cGMP Manufacturing and Formulation Support for Clinical Trials
Small-Animal Imaging• NanoSPECT/CT and PET• Image-based Metrology
Los Alamos National Laboratory• Isotope Production Facility• Chemistry Division• Biosciences Division
NMCIM Partnerships and AcknowledgementsNew Mexico Center for Isotopes in MedicineScott Burchiel, PhD UNM Assoc VP Research IASJohn Pieper, PharmD Dean COPCollege of Pharmacy, UNM HSCYubin Miao, PhD, Nalini Shenoy, PhD (Post-doc)Radiopharmaceutical Sciences LaboratoryTamara Anderson, BS (Associate Scientist)Ben Gershman, MS (Imaging Scientist)Jeremy Howard, BS (Sr./Lead BiologyTechnician)Daniel Irwin, BS (Nuclear Medicine Technologist)Tapan Nayak, BPharm, MS (PhD Candidate)Jack Hoppin, PhD et al. - Bioscan, Inc.Melanie Bergeron, MS et al. - GammaMedica Ideas (AMI)UNM Cancer Research Treatment CenterPathologyRichard Larson, MD, PhD (LFA-1 NorBIRT)David Brown, PhD (Survival studies)Gloria Semenuk, PhD (Affinity studies)Cell BiologyEric Prossnitz, PhD (Receptor biology)C Revankar, PhD & Daniel Cimino, PhDCenter for Molecular High Throughput ScreeningLarry Sklar, PhD (PI Keck Grant)Bruce Edwards, PhD & Mark Carter, MS
Los Alamos National LaboratoryRobert Atcher, PhD (Nuclear and Radiochemistry)Jonathon Fitzsimmons, PhD (Post-doc)Eugene Peterson, PhD (Nuclear Chemistry)NIH/NCI Radiation Oncology BranchMartin Brechbiel, PhD (Nuclear and Radiochemistry)Kayhan Garmestani, PhD (Radiochemistry)DOE Isotope Production ProgramWolfgang Runde, PhD
Research Support (Norenberg)WM Keck FoundationUnited States Department of Energy, Advanced Nuclear
Medicine Initiative DE-FG01-001NE23554University of New Mexico General Clinical Research Centers
DHHS/PHS/NIH/NCRR/GCRC, MO1 RROO997UNM-LANL Joint Science and Technology Laboratory
Initiatives (JSTL)New Mexico Technology Research Collaborative (TRC)UNM CRTC Translational Science Pilot AwardAvid Radiopharmaceuticals, Inc.Bioscan, Inc.GammaMedica Ideas (Advanced Molecular Imaging, Inc.)Molecular Insight Pharmaceuticals, Inc.Tyco/Mallinckrodt Healthcare - Covidien
