1

Peer reviewed articles of team 6 (2013-2017): Gilles PONCHEL, Christine VAUTHIER and Kawthar BOUCHEMAL

2017

GRISIN T, BORIES C, BOMBARDI M, LOISEAU P.M. ROUFFIAC V, SOLGADI A, MALLET J-M, PONCHEL G, BOUCHEMAL K. Supramolecular chitosan micro-platelets synergistically enhance anti-Candida albicans activity of amphotericin B using an immunocompetent murine model. Pharmaceutical Research. 2017, DOI:10.107/s11095-017-2117-3.

MAMADOU G, CHARRUEAU C, DAIROU J, LIMAS NZOUZI N, ETO B, PONCHEL G. Increased intestinal permeation and modulation of presystemic metabolism of 1 resveratrol formulated into self - emulsifying drug delivery systems. International Journal of Pharmaceutics. 2017, accepted

GRISIN T, BORIES C, LOISEAU P.M. BOUCHEMAL K. Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice. International Journal of Pharmaceutics. 2017, 519(1-2):381-389. DOI:10.1016/j.ijpharm.2017.01.048.

2

MUSUMECI G, BON I, LEMBO D, CAGNO V, RE MC, SIGNORETTO C, DIANI E, LOPALCO L, PASTORI C, MARTIN L, PONCHEL G, GIBELLINI D, BOUCHEMAL K. M48U1 and Tenofovir combination synergistically inhibits HIV-1 infection in activated PBMCs and human cervicovaginal histocultures. Scientific Reports, 2017;7:41018, DOI:10.1038/srep41018.

MALLI S, BORIES C, PRADINES B, LOISEAU P.M. PONCHEL G, BOUCHEMAL K. In situ forming pluronic F127/chitosan hydrogel limits metronidazole transmucosal absorption. European Journal of Pharmaceutics and Biopharmaceutics. 2017;112:143-147. DOI: 10.1016/j.ejpb.2016.11.024.

2016

VAUTHIER C, PONCHEL G. Polymer Nanoparticles for Nanomedicines, 2016, Springer.

BRAVO-OSUNA I, VICARIO-DE-LA-TORRE M, ANDRES GUERRERO V, SÁNCHEZ-NIEVES J, GUZMÁN NAVARRO M, DE LA MATA FJ, GÓMEZ R, DE

LAS HERAS B, ARGÜESO P, PONCHEL G, HERRERO-VANRELL R, MOLINA-MARTÍNEZ I. Novel water-soluble mucoadhesive carbosilane dendrimers for ocular administration. Mol. Pharm. 2016;13(9):2966-76. doi: 10.1021/acs.molpharmaceut.6b00182.

ARIEN K, BALEUX F, DESJARDINS D, PORROT F, COIC Y-M, MICHIELS J, BOUCHEMAL K, BONNAFFE D, BRUEL T, SCHWARTZ O, LE GRAND R, VANHAM G, DEREUDDRE-BOSQUET N, LORTAT-JACOB H. CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge. Scientific Reports. 2016;6:34829. DOI:10.1038/srep34829.

COTY JB, VARENE F, VACHON JJ, VAUTHIER C. Serial multiple crossed immunoelectrophoresis at a micro scale: a stamp-size 2D immunoanalysis of protein C3 activation caused by nanoparticles. Electrophoresis. 2016;37:2401–2409. DOI: 10.1002/elps.201500572.

3

DIAZ-SALMERON R, CHAAB I, CARN F, DJABOUROV M, BOUCHEMAL K. Pickering emulsions with alpha-cyclodextrin inclusions: Structure and thermal stability. Journal of Colloids and Interface Science. 2016;482:48-57. DOI: 10.1016/j.jcis.2016.07.033.

DJABOUROV M, BOUCHEMAL K. Polymer gels, hydrogels, and scaffolds – An overview. In Descamp M (ed). Disordered Pharmaceutical Materials, Wiley, New York, 2016, pp.241-282. DOI: 10.1002/9783527652693.ch9.

VARENNE F, MAKKI A, GAUCHER-DELMAS M, VIOLEAU F, VAUTHIER C. Multimodal dispersion of nanoparticles: a comprehensive evaluation of size distribution with 9 size measurement methods. Pharmaceutical Research. 2016;33:1220-1234. DOI: 10.1007/S11095-016-1867-7.

VARENNE F, BOTTON J, MERLET C, HILLAIREAU H, LEGRAND FX, BARRATT G, VAUTHIER C. Size of monodispersed nanomaterials evaluated by dynamic light scattering: Protocol validated for measurements of 60 and 203 nm diameter nanomaterials is now extended to 100 and 400 nm. International Journal of Pharmaceutics. 2016;515:245-253. DOI: 10.1016/j.ijpharm.2016.10.016

Platelets of O-palmitoyl-amylopectin/-CD in emulsions with 10/90wt.% silicone oil in transmission (left) and reflection (right) modes (bar = 10µm).

4

PALAZZO C, PONCHEL G, VACHON JJ, VILLEBRUN S, AGNELY F, VAUTHIER C. Obtaining non-spherical poly(alkylcyanoacrylate) nanoparticles by the stretching method applied with a marketed water soluble film. Int. J. Polym. Mater. DOI: 10.1080/00914037.2016.1233420.

XAVIER JUNIOR FH, GUEUTIN C, VALE MORAIS AR, NASCIMENTO ALENCAR E, TABOSA DO EGITO ES, VAUTHIER C. HPLC method for the dosage of paclitaxel in copaiba oil: development, validation, application to the determination of the solubility and partition coefficients. Chromatographia, 2016;79:405-412. DOI: 10.1007/s10337-016-3058-4.

XAVIER JUNIOR FH, HUANG N, VACHON JJ, REHDER VLG, EGITO EST, VAUTHIER C. Match of solubility parameters between oil and surfactant as a rational approach for the formulation of microemulsions with a high dispersed volume of copaiba oil and low surfactant content. Pharmaceutical Research. 2016;33:3031-3043. DOI:10.1007/s11095-016-2025-y.

5

GALUS A, MALLET J-M, LEMBO D, CAGNO V, DJABOUROV M, LORTAT-JACOB H, BOUCHEMAL K*. Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity. Carbohydrate Polymers. 2016;136:113-120. DOI: 10.1016/j.carbpol.2015.08.054.

2015

BARBIERI S, BUTTINI F, ROSSI A, BETTINI R, COLOMBO P, PONCHEL G, SONVICO F, COLOMBO G. Ex vivo permeation of tamoxifen and its 4-OH metabolite through rat intestine from lecithin/chitosan nanoparticles. International Journal of Pharmaceutics. 2015;I491(1-2):99-104.

LAURA DE MIGUEL, GERARDO CEBRIÁN-TORREJÓN, ERIC CAUDRON, LUDOVICA ARPINATI, ANTONIO DOMÉNECH-CARBÓ AND GILLES PONCHEL

Bone-Targeted Cisplatin-Complexed poly(γ-benzyl-L-glutamate)–poly(glutamic acid) Block Polymer Nanoparticles: An Electrochemical Approach. Chem Electro Chem. 2015;2(5):748-754. DOI:10.1002/celc.201402400.

CALLEJA P, ESPUELAS S, VAUTHIER C, PONCHEL G, IRACHE JM. Controlled Release, Intestinal Transport, and Oral Bioavailablity of Paclitaxel can be Considerably Increased Using Suitably Tailored Pegylated Poly(Anhydride) Nanoparticles. J Pharm Sci. 2015;104:2877-86. DOI:10.1002/jps.24354.

FORNAGUERA C., CALDERO G., MITJANS M., VINARDELL P., SOLANS C., VAUTHIER C. Interaction of PLGA nanoparticles with blood components: protein adsorption, coagulation, activation of the complement system and hemolysis studies. Nanoscale. 2015;7:6045-58. DOI: 10.1039/c5nr00733j.

6

FORNAGUERA C., CALDERO G., SOLANS C., VAUTHIER C. Protein-nanoparticle interactions evaluation by immunomethods: Surfactants can disturb quantitative determinations. Eur J Pharm Biopharm. 2015;94:284-90. DOI:10.1016/j.ejpb.2015.05.025.

DIOP M, AUBERVAL N, VICIGLIO A, LANGLOIS A, BIETIGER W, MURA C, PERONET C, BEKEL A, JULIEN DAVID D, ZHAO M, PINGET M, JEANDIDIER

N, VAUTHIER C, MARCHIONI E, FRERE Y, SIGRIST S. Design, characterisation, and bioefficiency of insulin-chitosan nanoparticles after stabilisation by freeze-drying or cross-linking. International Journal of Pharmaceutics. 2015;491:402-408. DOI:10.1016/j.ijpharm.2015.05.065.

VARENNE F, BOTTON J, MERLET C, BECK-BROICHSITTER M, LEGRAND FX, VAUTHIER C. Standardization and validation of a protocol of size measurements by dynamic light scattering for monodispersed stable nanomaterial characterization. Colloid and Surface A; Physicochemical and Engineering aspects. 2015;486:124–138 DOI:10.1016/j.colsurfa.2015.08.043.

7

VARENNE F, BOTTON J, MERLET C, VACHON JJ, GEIGER S, INFANTE IC, CHEHIMI MM, VAUTHIER C. Standardization and validation of a protocol of zeta potential measurements by electrophoretic light scattering for nanomaterial characterization. Colloid and Surface A; Physicochemical and Engineering aspects. 2015;486:218-231. DOI:10.1016/j.colsurfa2015.08.44.

PRADINES B, DJABOUROV M, VAUTHIER C, LOISEAU P. M, PONCHEL G, BOUCHEMAL K*. Gelation and micellization behaviors of pluronic F127 hydrogel containing poly(isobutylcyanoacrylate) nanoparticles specifically-designed for mucosal application. Colloids and Surfaces B: Biointerfaces. 2015;135:669-676. DOI: 10.1016/j.colsurfb.2015.08.021.

PRADINES B, LIEVIN-LE-MOAL V, VAUTHIER C, PONCHEL G, LOISEAU P. M, BOUCHEMAL K*. Cell-line-dependent cytotoxicity of (poly(isobutyl cyanoacrylate) nanoparticles coated with chitosan and thiolated chitosan: insights from cultured human epithelial HeLa, Caco2/TC7 and HT-29/MTX cells. International Journal of Pharmaceutics. 2015;491:17-20. DOI: 10.1016/j.ijpharm.2015.06.001.

8

BOUCHEMAL K*, AKA-ANY-GRAH A, DEREUDDRE-BOSQUET N, MARTIN L, LIEVIN-LE-MOAL V, LE GRAND R, NICOLAS V, GIBELLINI D, LEMBO D,

POÜS C, KOFFI A, PONCHEL G. Thermosensitive and mucoadhesive pluronic®/hydroxypropylmethylcellulose hydrogel containing the

mini CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervico-vaginal mucus. Antimicrobial Agents

and Chemotherapy. 2015;59(4) 2215-2222 DOI: 10.1128/AAC.03503-14.

SPECOGNA E, LI KW, DJABOUROV M, CARN F, BOUCHEMAL K*. Dehydration, dissolution, and melting of cyclodextrin crystals. The Journal

of Physical Chemistry B. 2015;119:1433-1442. DOI: 10.1021/jp511631e.

PRADINES B, BORIES C, VAUTHIER C, PONCHEL G, LOISEAU P.M, BOUCHEMAL K*. Drug-free chitosan coated poly(isobutylcyanoacrylate)

nanoparticles were active against Trichomonas vaginalis and non-toxic towards pig vaginal mucosa. Pharmaceutical Research.

2015;32:1229-1236.

PRADINES B, GALLARD J-F, IORGA B.I, GUEUTIN C, PONCHEL G, LOISEAU P.M, BOUCHEMAL K*. The unexpected increase of clotrimazole

apparent solubility using randomly methylated beta-cyclodextrin. Journal of Molecular Recognition. 2015;28:96-102.

DOI:10.1002/jmr.2432.

9

DE MIGUEL L, POPA I, NOIRAY M, CAUDRON E, ARPINATI L, DESMAELE D, CEBRIAN-TORREJON G, DOMENECH-CARBO A, PONCHEL G. Osteotropic polypeptide nanoparticles with dual hydroxyapatite binding properties and controlled cisplatin delivery. Pharm Res. 2015;32(5):1794-1803.

2014

DE MIGUEL L, NOIRAY M, SURPATEANU G, IORGA B.I, PONCHEL G. Poly(γ-benzyl-L-glutamate)-PEG-alendronate multivalent nanoparticles

for bone targeting. International Journal of Pharmaceutics. 2014;460(1-2):73-82.

BALEUX F, ARIEN K, DESJARDINS D, MICHIELS J, COIC Y-M, CONNEL B.J, BONNAFFÉ D, BOUCHEMAL K, LE GRAND R, VANHAM G, DEREUDDRE-

BOSQUET N, LORTAT-JACOB H. MiniCD4-heparan sulfate mimetic conjugates display sub nanomolar anti-HIV-1 activity and protect

macaques against a SHIV162P3 vaginal route challenge. AIDS Research and Human Retroviruses. 2014, 30 SUPPL 1, PAGES:A262.

PRADINES B, GALLARD J-F, IORGA B. I, GUEUTIN C, LOISEAU P. M, PONCHEL G, BOUCHEMAL K*. Investigation of the complexation of

albendazole with cyclodextrins for the design of new antiparasitic formulations. Carbohydrate Research. 2014;398:50-55.

LEMBO D, DONALISIO M, LAINE C, CAGNO V, CIVRA A, BIANCHINI E.P, ZEGHBIB N, BOUCHEMAL K*. Auto-associative heparin

nanoassemblies: a biomimetic platform against the heparan-sulfate-dependent viruses HSV-1, HSV-2, HPV-16 and RSV. European

Journal of Pharmaceutics & Biopharmaceutics. 2014;88:275-282.

VALETTI S, MAIONE F, MURA S, STELLA B, DESMAELE D, NOIRAY M, VERGNAUD J, VAUTHIER C, CATTEL L, GIRAUDI E, COUVREUR P. Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor. Journal of Controlled Release. 2014;192:29-39.

2013

NGUYEN V.N, HUANG N, GROSSIORD J.-L, MOINE L, AGNELY F, VAUTHIER C. Rheological characterization of mechanical properties of chemically crosslinked microspheres. Appl. Polym. Sci. 2013;128:3113-3121.

NGUYEN V. N, VAUTHIER C, HUANG N, GROSSIORD J.-L, MOINE L, AGNELY F. Degradation of hydrolyzable hydrogel microspheres. Soft Matter. 2013;9:1929-1936.

RAMON A.L, BERTRAND J.R, DE MARTIMPREY H, BERNARD G, PONCHEL G, MALVY C, VAUTHIER C. SiRNA associated with immunonanoparticles directed against cd99 antigen improve gene expression inhibition in vivo in Ewing's sarcoma. J. Mol. Recognition. 2013;26:318-329.

VAUTHIER C, ZANDANEL C, RAMON A. L. Chitosan-based nanoparticles for in vivo delivery of interfering agents including siRNA. Current Opinion in Colloid and interface Science. 2013;18:406-418.

DUC TRUNG B, MAKSIMENKO A, DESMAELE D, HARRISSON S, VAUTHIER C, COUVREUR P, NICOLAS J. Polymer prodrug nanoparticles based on naturally occuring isoprenoid for anticancer therapy. Biomacromolecules. 2013;14:2837-2847.

CAUCHOIS O, SEGURA-SANCHEZ F, PONCHEL G. Molecular weight controls the elongation of oblate-shaped degradable poly(ϓ-benzyl-L-glutamate) nanoparticle. International Journal of Pharmaceutics. 2013;452(1-2):292-299.

Representation of the complex of Me-β-CD

(yellow) with clotrimazole (CTZ, cyan) obtained

by molecular docking with 1:1 (higher panels)

and 2:1 (lower panels) stoichiometry.

Surfaces colored in yellow and cyan represent

solvent accessible surfaces for Me-β-CD and

CTZ, respectively.

10

AGOSTONI V, ANAND R, MONTI S, HALL S, MAURIN G, HORCAJADA P, SERRE C, BOUCHEMAL K, GREF R*. Impact of phosphorylation on the

encapsulation of nucleoside analogues within porous iron(III) metal-organic framework MIL-100(Fe) nanoparticles. Journal of

Materials Chemistry. 2013;1:4231-4242, DOI:10.1039/c3tb20653j.

STUMPO M, ANSELMI C, MITRI K, HANNO I, NEBIH M.Z, HUANG N, BOUCHEMAL K*. Successful scale-up of polyamide and polyester Parsol®

MCX nanocapsules by interfacial polycondensation and solvent diffusion method. International Journal of Pharmaceutics.

2013;454:678-685. DOI:10.1016/j.ijpharm.2013.06.062.

RAVANI L, ESPOSITO E, BORIES C, LIEVIN-LEMOAL V, LOISEAU P, DJABOUROV M, CORTESI R*, BOUCHEMAL K. Semisolid formulations based

on nanostructured lipid carrier (NLC) with anti-Candida albicans activity. International Journal of Pharmaceutics. 2013;454:695-702.

DOI:10.1016/j.ijpharm.2013.06.015.

MAZZAFERRO S, BOUCHEMAL K*, PONCHEL G. Oral delivery of anti-cancer drugs III: Formulation of anti-cancer drugs using drug delivery

systems. Drug Discovery Today. 2013;18:99-104. DOI:10.1016/j.drudis.2012.08.007.

AGOSTONI V, CHALATI T, HORCAJADA P, WILLAIME H, ANAND R, SEMIRAMOTH N, BAATI T, HALL S, MAURIN G, CHACUN H, BOUCHEMAL K,

MARTINEAU C, TAULELLE F, COUVREUR P, ROGEZ-KREUZ C, CLAYETTE P, MONTI S, SERRE V, GREF R. Towards an improved anti-HIV

Activity of NRTI via metal organic frameworks nanoparticles. Advanced Healthcare Materials. 2013;2(12):1630-1637.

DOI:10.1002/adhm.201200454.

BOUCHEMAL K*, FRELICHOWSKA J, MARTIN L, LIEVIN-LE-MOAL V, LEGRAND R, DEREUDDRE-BOSQUET N, DJABOUROV M, AKA-ANY-GRAH A,

KOFFI A, PONCHEL G. Formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the CD4 miniprotein M48U1 as

a novel anti-HIV-1 microbicide. International Journal of Pharmaceutics. 2013;454:649-652. DOI:10.1016/j.ijpharm.2013.02.055.

MAZZAFERRO S, BOUCHEMAL K*, PONCHEL G. Oral delivery of anti-cancer drugs II: The prodrug strategy. Drug Discovery Today.

2013;18:93-98. DOI:10.1016/j.drudis.2012.08.006.

ZHANG M, DJABOUROV M, BOURGAUX C, BOUCHEMAL K*. Nanostructured fluids from pluronic® mixtures. International Journal of

Pharmaceutics. 2013;454:599-610. DOI:10.1016/j.ijpharm.2013.01.043.

MAZZAFERRO S, BOUCHEMAL K*, PONCHEL G. Oral delivery of anti-cancer drugs I: General considerations. Drug Discovery Today.

2013;18:25-34. DOI:10.1016/j.drudis.2012.08.004.