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Hp-35 (1972) ABC80 (1978)
16 kB RAM
Sparc Station
Beginning of the 90’s
Up to 500 MB in RAM
Slide rule
A Brief personal history of computing
Technology is transforming biomedicine from a predominantly descriptive science into a data intensive modeling science
EDELFELT, portrait of Louis Pasteur, 1885 The HUNT Biobank NTNU, Norway
Illumina X10
Google trends Personalized Medicine vs Precision Medicine
Personalized Medicine became a buzzword after 2005
PLoS Medicine Vol 2, Issue
8, August 2005
Nature Vol 405
June 2000
WE NEED NEW STANDARDS
MATHEMATICAL MODELLING
AND SOLID STATISTICS
“All models are wrong but some are useful.”
p-values need to be backed up with biology
Check out TED talk style presentations available
under The Precision Medicine Revolution under
MEDIA at www.mispcamp.org
Current global initiatives for data standardization and data exploitation need to
be broadened, deepened and propelled by a catalyzing ecosystem built by key
global partners dedicated to sustainably work together within a joint modeling
and analysis space supporting innovation
A coordinated network of resource hubs covering all continents and providing bio-banking, data generation (sequencing, spectrometry, cytometry, etc.), data storage and high performance computing resources federated through the OHIS
Global Health Genomics Center
A network of private non-profit and national institutes 33 Institutes/ 27 countries
A community of scientists, laboratory and public health experts
Acting locally as a Global Network
A backbone for the global ecosystem: The Institut Pasteur International Network- A global network of 33 Institutes
Aligning bio-banking, data generation, data storage, data management and data modeling, analysis and visualization.
Federating the network of resource hubs that provide infrastructure and resources
The collaborative platform: The Open Health Innovation Space
GHGC: Resource hubs for sample collection and biobanks
HUNT BIOBANK NTNU Norway
L. RUBENSTEIN/BROAD INSTITUTE BIOBANK
Five countries, variable genetics, diverse lifestyles & environment
Establishing population-specific baseline measurements
Bringing diagnostic tools to the world Building on the Milieu Interieur Project, http://www.milieuinterieur.fr/en
Flagship projects powered by the Open Health Innovation Space. Example: The Healthy Human Global Project (HHG) Delineating the boundaries of a healthy human immune response Providing the base line for precision therapeutics
Whole blood
50ml
Nasal swabs
/Stool
X multiple stimulations
Field testing
Clinical
data Serology
Multiple donors x multiple continents age and sex stratification
1000 eCRF
≥ 300 var / p
60.000
Supernatant
Tubes
≈ 50 var / tube
≈ 250 var / p
20.000
RNA
profiles
≥ 600 var / tube
≥ 3000 var / d
12000 FCS files
≥ 500 var / p
3 Panels 2000 Genotypes
750K var / p
1000
Enterotypes 16S rRNA NGS
The HHG project : Building capacity & an unprecedented data warehouse
SAGE Bionetworks The Synapse platform
Stephen Friend MD. PhD. Apple
Chairman and Co-Founder of Sage Bionetworks
• CD3 + CD28
stimulation
after 22 h
• Null
stimulation
after 22 h
Group of 6 non
responders clustering
with the null stimulated
Gene expression separating 25
healthy subjects from 25
CD3+CD28 stimulated subjects
in a PCA plot
Discovery of non responders
Population stratification
for e.g. precision
vaccine development