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©2012 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA and SIGMA-ALDRICH are trademarks of Sigma-Aldrich

Co. LLC, registered in the US and other countries. SAGE is a registered trademark of Sigma-Aldrich Co. LLC.

Where bio begins is a trademark of Sigma-Aldrich Co. LLC.

Biovital.

The theme for the meeting points to the “unreasonable effectiveness” of the scientific enterprise in

creating economic growth, solving societal problems, and satisfying the essential human drive to

understand the world in which we live.

The phrase, “unreasonable effectiveness,” was coined in 1960 by physicist EugeneWigner, who

explored the duality of mathematics— both beautiful unto itself, and also eminently practical, often in

unexpected ways.

The scientific program will highlight the rich and complicated connections between basic and applied

research, and how they bring about both practical benefits and the beauty of pure understanding.

Student Poster Competition

The competition recognizes the individual efforts of students actively working toward an undergraduate,

graduate, or doctoral degree.Online entries will be accepted beginning 14May 2012.

For information about exhibits and sponsorships, contact meetings@aaas.org.

2013 AAAS ANNUALMEETING

14–18 February • Boston

www.aaas.org/meetings

Call for Symposium ProposalsSymposium proposals for the 2013 AAAS Annual Meeting are now being solicited. To submit aproposal, visit www.aaas.org/meetings. The deadline for submission is Thursday, 26 April 2012.

The Beauty and Benefits of Science

MOLECULAR BIOLOGY SUMMER WORKSHOPS

~ 27TH ANNUAL ~

www.neb.com

Learn Molecular Biology in 2 Weeks!We are pleased to announce the twenty-seventh annual Molecular Biology Summer Workshops, sponsored

by New England Biolabs in conjunction with Smith College. Workshops are held at Ford Hall, Smith College,

Northampton, MA, USA. Well over 3,000 people have graduated from this intensive training program in the past

twenty-six years. These intensive courses emphasize hands-on molecular biology laboratory work and cover a

wide variety of topics and techniques. This course is the largest and longest running molecular biology course for

professionals in the world. No prior experience in molecular biology is required.

when:two-week sessions:

Session 1: June 10 - June 23, 2012

Session 2: July 8 - July 21, 2012

where:Ford Hall

Smith College

Northampton, MA USA 01063

Dr. Steven A. Williams, Director

to apply:website:

http://www.science.smith.edu/neb

email:

biolabs@smith.edu

phone:

(413) 585-3915

topics/techniques:• gene cloning

(and library construction)

• gene expression analysis

• PCR and quantitative RT-PCR

• genomics and bioinformatics

• DNA sequencing

& next-gen sequencing

• RNAi, siRNA and microarrays

• and much more — visit our

website for a complete list!

Two-week Molecular Biology Sessions AvailableBoth two-week long courses cover in-depth DNA cloning, PCR, DNA sequencing, genomics,

next-gen sequencing and bioinformatics. Learn hands-on techniques used in gene expression

analysis including microarray analysis, RNAi and quantitative RT-PCR, bioinformatics and

genomics and proteomics.

application information: No previous experience in molecular biology is required or

expected. Forty participants per session will be selected from a variety of disciplines and

academic backgrounds, including principal investigators, directors of programs, medical

doctors, postdoctoral fellows, graduate students, research assistants, sales associates,

equipment engineers, etc.

fee: $3995 per participant. This fee includes lab manual, use of all equipment and supplies,

and room and board (all rooms are singles).

application deadlines: June 1, 2012 for session 1 and July 1, 2012 for session 2.

First come, first served (apply now!). Late applications will be accepted on a space available basis.

payment deadline: Three weeks following receipt of your email acceptance letter.

Better inside. Outside. Upside.

MiSeq™

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Bio-Rad’s QX100™ Droplet Digital™ PCR system provides

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Learn how current eventsare impacting your work.

ScienceInsider, the new policy blog from the journalScience, is your source for breaking news and instantanalysis from the nexus of politics and science.

Producedbyan international teamofscience journalists,ScienceInsideroffershard-hitting coverageon a rangeofissues including climate change, bioterrorism, researchfunding, andmore.

Before research happens at the bench, science policy isformulated in the halls of government. Make sure youunderstandhow currenteventsare impacting yourwork.Read ScienceInsider today.

Breaking news and analysis from

the world of science policy

www.ScienceInsider.org

FOCUS ON CAREERS

Bioclusters: Eastern U.S.

In This Issue

For scientists pursuing careers in biotech, clusters of life science-

related companies and research institutions in the eastern United

States may be a promising place to look for jobs. These so-called

bioclusters have a 30-year history in the region and, in recent years,

have seen an uptick in active support from academic institutions

and state and local governments. We focus on three leaders in the

region, the bioclusters in Massachusetts, Maryland/Washington, DC,

and North Carolina.

See full story on page 101.

Upcoming FeaturesBioclusters: Western U.S.�May 4

Biotech/Pharma: Navigating Mergers/Acquisitions�June 8

Diversity: Promoting New Perspectives�July 20

Produced by the Science/AAAS Custom Publishing Office

Opportunities in

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Abstract Submission Now Open

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©2012, American Heart Association 3/12DS5623 12-132

Abstract Submission Late-Breaking Clinical Trial Application

April 17–June 6, 5 PM CDT | UTC -5 Hours June 11–July 2, 5 PM CDT | UTC -5 Hours

Congratulations to Dr. Tiago Branco on winning the 2011 Eppendorf & Science Prize for his studies on how

dendrites discriminate temporal input sequences and apply different integration rules depending on input

location. The results of Dr. Branco’s research provide insight on how the brain performs computations, and

suggest that even single neurons can solve complex computational tasks.

You could be the 11th winner of this award.

The annual Eppendorf & Science Prize for Neurobiology honors young scientists for their outstanding contribu-

tions to neurobiological research based on methods of molecular and cell biology. The winner and finalists are

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To be eligible, you must be 35 years of age or younger. If you’re selected as this year’s winner, you will receive

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Past winners and finalists have come from as far a field as China, Chile, India and New Zealand.

Yes, it can happen to you. Enter your research now!

Eppendorf & Science Prizefor Neurobiology

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Dr. Tiago Branco

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Deadline for entries:

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Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are

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Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

PROTEASES

Four new, high quality proteases are now offered: Pepsin, Elastase,

Sequencing Grade Arg-C, and Thermolysin. These proteases are

provided in a lyophilized format, enabling resuspension in any buffer.

Applications include use in peptide mapping and protein identifi ca-

tion experiments, and in characterization of posttranslational modifi -

cations. Pepsin preferentially cleaves at the C-terminus of phenylala-

nine, leucine, tyrosine, and tryptophan. Elastase is a serine protease

that has a unique capability of digesting elastin, preferentially cleav-

ing at the C-terminus of alanine, valine, serine, glycine, leucine, or

isoleucine. Arg-C (clostripain) is a sequencing grade endopeptidase

that cleaves at the C-terminus of arginine residues, including sites

next to proline. Cleavage also will occur at lysine residues. Thermo-

lysin is a thermostable metalloproteinase with optimal digestion tem-

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PEI TRANSFECTION REAGENT

PEIpro is the next generation of linear PEI (polyethylenimine) trans-

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scientists working on large-scale transient transfection. PEIpro is a

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vated in serum-free culture media.

Polyplus-transfection

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SERIAL FRACTIONATION

Two-dimensional electrophoresis and mass spectrometry is routinely

used for identifi cation of novel proteins. However, the greatest chal-

lenge in protein identifi cation is achieving suitable resolution of pro-

teins. The high dynamic range of a species’ proteome means that

the more abundant proteins mask the less abundant and often more

interesting proteins. By fractionation, one simplifi es a protein mix-

ture by reducing the amount and the number of protein species to

be loaded onto the gel matrix. Fractionation produces less crowded

individual protein maps, simplifying analysis and interpretation. G-

Biosciences has developed a simple and reproducible method of se-

rial fractionation of total cellular proteins. Fraction-FOCUS utilizes

proven technology to fractionate and concentrate all proteomes into

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lows for improved resolution and simplifi ed 2-D maps, which in turn

allows for improved analysis and interpretation and greatly increases

the chances of identifying novel and less abundant proteins. Frac-

tion-FOCUS is fully compatible with 2-D electrophoresis or isoelec-

tric focusing and other applications.

G-Biosciences

For info: 800-628-7730 www.gbiosciences.com

GEL IMAGING SYSTEM

The new U:Genius3 is a compact, simple to set up gel-imaging

system, which comes with a sensitive 3 megapixel CCD camera

inside a compact darkroom. The cost-effective system includes

overhead Epi white light and is versatile, offering multiple illumina-

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tein gels stained with a range of dyes. The U:Genius3 features a

built in processor and a simple to use, intuitive “button controlled”

integral key pad. The system can be fi tted with the new Ultra-Slim

LED Blue Light Transilluminator in laboratories where safety and

ultraviolet sample damage are issues. The transilluminator slides

out of the darkroom to aid viewing and band cutting, and there

is also a white light converter screen option available for scien-

tists wanting to view protein gels, thus maximizing the use of vital

laboratory space.

Syngene

For info: 800-686-4407 www.syngene.com

PROTEIN PREPARATION KIT

The Subcellular Protein Fractionation Kit enables the step-wise preparation of cyto-

plasmic, membrane, soluble nuclear, chromatin-bound, and cytoskeletal protein frac-

tions with less than 15% cross-contamination in two hours. The resultant samples are

ideal for downstream analyses, including Western blotting, protein quantitation, elec-

trophoretic mobility shift, and reporter gene assays. The versatile kit is optimized for

use with a variety of tissue types, including liver, heart, brain, kidney, lung, and spleen.

The Subcellular Protein Fractionation Kit contains optimized formulations and protocols

for the specifi c protein fractionation of tissues samples, saving researchers time and

money. The kit also includes the uniquely designed Thermo Scientifi c Pierce Tissue

Strainer, which quickly separates cells or lysates from tissue debris after mechanical

disruption. The device contains a 250 μm mesh fi lter and fi ts into standard 15 mL coni-

cal tubes. The Pierce Tissue Strainer is also available separately.

Thermo Fisher Scientifi c

For info: 800-874-3723 www.thermoscientifi c.com/pierce

New Products

Produced by the Science/AAAS Custom Publishing Office LLIIFFEE SSCCIIEENNCCEE TTEECCHHNNOOLLOOGGIIEESS

MATERIALS FOR ENERGY TECHNOLOGIES

A Compliant Energy Sources

B Thermoelectric Materials Research and Device Development

for Power Conversion and Refrigeration

C Electrocatalysis and Interfacial Electrochemistry

for Energy Conversion and Storage

D Energy-Critical Materials

E Photovoltaic Technologies—Materials, Devices, and Systems

F Oxide Thin Films for Renewable Energy Applications

G Materials as Tools for Sustainability

H Small-Molecule Organic Solar Cells

I Functional Materials for Solid Oxide Fuel Cells

J Materials Aspects of Advanced Lithium Batteries

K Hierarchically Structured Materials for Energy Conversion

and Storage

SOFT MATERIALS AND BIOMATERIALS

L Biomimetic Nanoscale Platforms, Particles, and Scaffolds

for Biomedical Applications

M Bioinspired Directional Surfaces—From Nature

to Engineered Textured Surfaces

N Precision Polymer Materials—Fabricating Functional

Assemblies, Surfaces, Interfaces, and Devices

O Next-Generation Polymer-based Organic Photovoltaics

P Single-Crystalline Organic and Polymer Semiconductors—

Fundamentals and Devices

Q Functional and Responsive Materials Exploiting Peptide

and Protein Self-Assembly

R Fundamentals of Assembly in Biomolecular

and Biomimetic Systems

S Directed Self-Assembly for Nanopatterning

T Membrane Material Platforms and Concepts

for Energy, Environment, and Medical Applications

U Colloidal Crystals, Quasicrystals, Assemblies, Jammings,

and Packings

FUNCTIONAL MATERIALS AND NANOMATERIALS

V Geometry and Topology of Biomolecular and Functional

Nanomaterials

W Carbon Nanomaterials

Y Combustion Synthesis of Functional Nanomaterials

Z Oxide Semiconductors

AA Oxide Nanoelectronics and Multifunctional Dielectrics

BB Recent Advances in Optical, Acoustic, and Other Emerging

Metamaterials

CC Optically Active Nanostructures

DD Group IV Semiconductor Nanostructures and Applications

EE Diamond Electronics and Biotechnology—

Fundamentals to Applications VI

FF Semiconductor Nanowires—Optical and Electronic

Characterization and Applications

STRUCTURAL AND ADVANCED MATERIALS

GG Mechanical Behavior of Metallic Nanostructured Materials

HH Advances in Materials for Nuclear Energy

II Atomic Structure and Chemistry of Domain Interfaces

and Grain Boundaries

JJ Intermetallic-based Alloys—Science, Technology,

and Applications

KK Complex Metallic Alloys

LL Scientific Basis for Nuclear Waste Management XXXVI

MM Materials under Extreme Environments

NN Structure-Property Relations in Amorphous Solids

OO Properties, Processing, and Applications

of Reactive Materials

SYNTHESIS, CHARACTERIZATION, AND MODELING

METHODS

PP Frontiers of Chemical Imaging—

Integrating Electrons, Photons, and Ions

QQ Materials Informatics

RR Advanced Multiscale Materials Simulation—

Toward Inverse Materials Computation

SS Quantitative In situ Electron Microscopy

TT Defects and Microstructure Complexity in Materials

UU Scanning Probe Microscopy—Frontiers in Nanotechnology

VV Advanced Materials Exploration with Neutrons

and Synchrotron X-Rays

WW Roll-to-Roll Processing of Electronics

and Advanced Functionalities

XX Materials and Concepts for Biomedical Sensing

YY Low-Voltage Electron Microscopy and Spectroscopy

for Materials Characterization

GENERAL

ZZ Communicating Social Relevancy in Materials Science

and Engineering Education

AAA The Business of Nanotechnology IV

www.mrs.org/fall2012

DON’T MISS THESE FUTURE MRS MEETINGS!

XXI International Materials Research Congress (IMRC) 2012

August 13-17, 2012

Cancún, Mexico

2013 MRS Spring Meeting & Exhibit

April 1-5, 2013

San Francisco, California

506 Keystone Drive Warrendale, PA 15086-7573

Tel 724.779.3003 Fax 724.779.8313

info@mrs.org www.mrs.org

Abstract Deadline • June 19, 2012 Abstract Submission Site Opens May 19, 2012

November 25 – 30

Boston, MA

Chennupati JagadishAustralian National University

jagadish.mrs@gmail.com

2012 MRS FALL MEETING CHAIRS

Thomas LippertPaul Scherrer Institut

thomas.lippert@psi.ch

Amit MisraLos Alamos National Laboratory

amisra@lanl.gov

Eric StachBrookhaven National Laboratory

stach.fall2012@gmail.com

Ting XuUniversity of California, Berkeley

tingxu.fall2012@gmail.com

The second annual E-MRS/MRS Bilateral Conference on Energy

will be comprised of the energy-related symposia at

the 2012 MRS Fall Meeting.

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