CURRICULUM VITAE

Michael J. Oglesbee

Revised 3-2018

I) BIOGRAPHICAL STATEMENT Education:

The Ohio State University 1980-1984 D.V.M. summa cum laudeCollege of Veterinary Medicine

The Ohio State University 1984-1988 Ph.D.College of Veterinary MedicineDepartment of Veterinary PathobiologyDissertation: Canine Distemper Virus Nucleocapsid: Relevance to Persistence

Board Certification:

Diplomate, American College of Veterinary Pathologists (1990)

Major Professional Interests:

The role of the cellular stress response in viral pathogenesis and antiviral immunityEmphasis on paramyxoviruses (measles, canine distemper), rhabdoviruses

Viral neuropathology/comparative neuropathology

Professional Appointments:

1980-1983 Research Assistant, Department of Medicinal Chemistry (College of Pharmacy); Department of Internal Medicine (College of Medicine), Department of Anatomy (College of Veterinary Medicine), The Ohio State University

1984-1987 Graduate Fellow, Dupont Corporation, Department of Veterinary Pathobiology, The Ohio State University

1987-1989 Post-Doctoral Fellow, National Institutes of Health, National Research Service Award, Department of Veterinary Pathobiology, The Ohio State University

1989-1995 Assistant Professor, Department of Veterinary Pathobiology, The Ohio State University

1995-2001 Associate Professor, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio (joint appointment in the Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine, The Ohio State University, beginning 1998).

2001-present Professor, Department of Veterinary Biosciences and the Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University

2010-11 Interim Chair, Department of Veterinary Biosciences, The Ohio State University

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2011-2017 Chair, Department of Veterinary Biosciences, The Ohio State University2015-present Faculty Lead, Discovery Theme in Infectious Diseases, The Ohio State

University2017-present Director, Infectious Diseases Institute, The Ohio State University

Honors 1988-90 National Research Service Award (NRSA), NIH, NIAID, 1996 Pfizer Award for Research Excellence, College of Veterinary Medicine, The Ohio

State University 2004 Charles C. Capen Teaching Excellence Award for Graduate Education, College of

Veterinary Medicine, The Ohio State University 2015 Fellow, American Associated for the Advancement of Science

The recognition reflects distinguished contributions to our understanding of virus-heat shock protein interactions related to infection, virulence and impact on innate and adaptive antiviral immunity

Active Membership in Research Centers

Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Research Institute, The Ohio State University

Infectious Diseases Institute, The Ohio State University

Active Membership in Professional Societies

American College of Veterinary PathologistsAmerican Association for the Advancement of ScienceAmerican Society for VirologyAmerican Society for MicrobiologyOhio Veterinary Medical Association

Graduate Faculty Status: P

a) Graduate program in Comparative and Veterinary Medicine, The Ohio State University College of Veterinary Medicine

b) Integrated Biomedical Sciences Graduate Program, The Ohio State University College of Medicine

c)

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II) PUBLICATIONS

A) Journal Articles – Peer Reviewed

1) Oglesbee, M., Jackwood, D., Perrine, K., Axthelm, M., Krakowka, S., and Rice, J. (1986). In vitro detection of canine distemper virus nucleic acid with a virus-specific cDNA probe by dot-blot and in situ hybridization. Journal of Virological Methods 14:195-211.

2) Shulaw, W., and Oglesbee, M. (1988). A unique clinical and pathological variant of malignant catarrhal fever in white-tailed deer. Journal of Wildlife Disease 25(1):112-117.

3) Oglesbee, M., Tatalick, L., Ringler, S., Rice, J., and Krakowka, S. (1989). Rapid isolation of morbillivirus nucleocapsid for genomic RNA cDNA cloning and the production of specific core protein antisera. Journal of Virological Methods 24:285-300.

4) Oglesbee, M., Tatalick, L., Rice, J., and Krakowka, S. (1989). Isolation and characterization of canine distemper virus nucleocapsid variants. Journal of General Virology 70:2409-2419.

5) Oglesbee, M., Ringler, S., and Krakowka, S. (1990). Interaction of canine distemper virus nucleocapsid variants with 70k heat shock proteins. Journal of General Virology 71:1585-1590.

6) Oglesbee, M. (1992). Intranuclear inclusions in paramyxovirus-induced encephalitis: evidence for altered nuclear body differentiation. Acta Neuropathologica 84:407-415.

7) Oglesbee, M., and Krakowka, S. (1993). The cellular stress response induces selective intranuclear trafficking and accumulation of morbillivirus major core protein. Laboratory Investigation 68(1):109-117.

8) Oglesbee, M., Kenney, H., Kenney, T., and Krakowka, S. (1993). Enhanced production of morbillivirus gene-specific RNAs following induction of the cellular stress response in stable persistent infection. Virology 192:556-567.

9) Podell, M., Oglesbee, M., Mathes, L., Krakowka, S., Olmstead, R., and Lafrado, L. (1993). AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection. Journal of Acquired Immunodeficiency Syndromes 6:758-771.

10) Kenney, H., and Oglesbee, M. (1994). Sensitive detection of morbillivirus cell-free transcription in a direct RNase protection assay. Journal of Virological Methods 48:197-210.

11) Oglesbee, B., and Oglesbee, M. (1994). Feather dystrophy in a cockatiel (Nymphicus hollandicus). Journal of the Association of Avian Veterinarians 8(1):16-20.

12) Andrews, J., Oglesbee, M., Trevino, A., Guyot, D., Newbound, G., Lairmore, M. (1995). Enhanced human T cell lymphotrophic virus type I expression following induction of the cellular stress response. Virology 208:816-820.

13) Wicks, J.R., and Oglesbee, M. (1995). Epithelioma of the fourth ventricle in a goat. Veterinary Pathology 32:429-433.

14) Dunigan, C.E., Oglesbee, M.J., Mitten, L.A., Reed, S.M. Seizure activity associated with equine protozoal myeloencephalitis (1995). Progress in Veterinary Neurology 6:50-54.

15) Ruehlmann, D., Podell, M., Oglesbee, M., and Dubey J.P. Canine neosporosis: case report and literature review (1995). Journal of the American Animal Hospital Association 31:174-183.

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16) Xing, S., Smanik, P.A., Oglesbee, M., Trosko, J.E., Mazzaferri, E.L., Jhiang, S. (1996). Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes. Endocrinology 137:1512-1519.

17) Oglesbee, M.J., Liu, Z., Kenney, H., Brooks, C. (1996). The highly inducible member of heat shock proteins increases canine distemper virus polymerase activity. Journal of General Virology 77:2125-2135.

18) Podell, M., Shelton, G.D., Nyhan, W.L., Wagner, S.O., Oglesbee, M., Fenner, W.R. (1996). Methylmalonic and malonic aciduria in a dog with progressive encephalopathy. Metabolic Brain Disease 11(3): 239-247.

19) Andrews, J., Newbound, G., Oglesbee, M., Brady, J., Lairmore, M. (1997). The cellular stress response enhances HTLV-1 basal gene expression through the basal core promoter of the long terminal repeat. Journal of Virology 71(1): 741-745.

20) Liu, Z., Huntley, C.C., De, B.P., Das, T., Banerjee, A.K., Oglesbee, M. (1997). Phosphorylation of canine distemper virus P protein by protein kinase C-ζ and casein kinase II. Virology 232(1): 198-206.

21) Podell, M., Hayes, K., Oglesbee, M., Mathes, L. (1997). Progressive encephalopathy associated with CD4/CD8 inversion in adult FIV infected cats. Journal of Acquired Immunodeficiency Syndromes 15:332-340.

22) Heller, M., Vasconcelos, D., Cummins, J., Oglesbee, M. (1998). Interferon-α inhibits the emergence of cellular stress response-dependent morbillivirus large plaque variants. Antiviral Research 38:195-207.

23) Vasconcelos, D., Norrby, E., Oglesbee, M. (1998). The cellular stress response increases measles virus-induced cytopathic effect. Journal of General Virology 79:1769-1773.

24) Oglesbee, B., Oglesbee, M. (1998). Post mortem findings in psittacine birds with cardiac disease: 26 cases (1991-1995). Journal of the American Veterinary Medical Association 212(11): 1737-1742.

25) Vasconcelos, D., Cai, X.H., Oglesbee, M.J. (1998). Constitutive over-expression of the major inducible 70 kDa heat shock protein mediates large plaque formation by measles virus. Journal of General Virology 79:2239-2247.

26) Andrews, J., Oglesbee, M., Lairmore, M. (1998). The effect of the cellular stress response on human T-cell lymphotrophic virus type 1 envelope protein expression. Journal of General Virology 79:2905-2908.

27) Kearns, R.J., Ringler, S., Krakowka, S., Tallman, R. Sites, J., Oglesbee, M.J. (1999). The effects of extracorporeal whole body hyperthermia on the functional and phenotypic features of canine peripheral blood mononuclear cells. Clinical and Experimental Immunology 116:188-192.

28) Oglesbee, M.J., Diehl, K., Crawford, E., Kearns, R., and Krakowka, S. (1999). Whole body hyperthermia: effects upon canine immune and hemostatic functions. Veterinary Immunology and Immunopathology 69:185-199.

29) Diehl, K.A., Crawford, E., Shinko, P.D., Tallman, R.D., Oglesbee, M.J. (2000). Alterations in hemostasis associated with hyperthermia in a canine model. American Journal of Hematology 64(4):262-270.

30) Wuenschmann, A., Oglesbee, M. (2001). Periventricular changes associated with spontaneous canine hydrocephalus. Veterinary Pathology 38(1):67-73.

31) Saville, W.J.A., Stich, R.W., Njoku, C.J., Oglesbee, M.J., Wuenschmann, A., Grover, D.L., Larew-Naugle, A.L., Stanek, J.F., Granstrom, D.E., Dubey, J.P., Reed, S.M. (2001). Utilization of stress in the development of a model for equine protozoal myeloencephalitis (EPM). Veterinary Parasitology 95(2-4):211-222.

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32) Lacombe, V.A., Podell, M., Furr, M., Reed, S.M., Oglesbee, M.J., Hinchcliff, K.W., Kohn, C.W. (2001). Diagnostic validity of eletroencephalography in equine intracranial disorders. Journal of Veterinary Internal Medicine 15(4):385-93.

33) Dubey, J.P., Saville, W.J., Stanek, J.F., Lindsay, D.S., Rosenthal, B.M., Oglesbee, M.J., Rosypal, A.C., Njoku, C.J., Stich, R.W., Kwok, O.C., Shen, S.K., Hamir, A.N., Reed, S.M. (2001). Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoons. Veterinary Parasitology 100(3-4):117-29.

34) Oglesbee, M.J., Alldinger, S., Vasconcelos, D., Diehl, K., Shinko, P., Baumgärtner, W., Tallman, R., Podell, M. (2002). Intrinsic thermal resistance of the canine brain. Neuroscience 113(1):55-64.

35) Njoku, C.J., Saville, W.J.A., Reed, S.M., Oglesbee, M.J., Rajala-Schultz, P.J., Stich, R.W. (2002). Reduced levels of nitric oxide metabolites in cerebrospinal fluid are associated with equine protozoal myeloencephalitis. Clinical and Diagnostic Laboratory Immunology 9(3):605-610.

36) Zhang, X., Glendening, C., Linke, H., Parks, C.L., Brooks, C., Udem, S.A., Oglesbee, M. (2002). Identification and characterization of a regulatory domain on the carboxyl terminus of the measles virus nucleocapsid protein. Journal of Virology 76(17):8737-8746.

37) Stanek, J.F., Dubey, J.P., Oglesbee, M.J., Reed, S.M., Lindsay, D.S., Capitini, L.A., Njoku, C.J., Vittitow, K.L., Saville, W.J. (2002). Life cycle of Sarcocystis neurona in its natural intermediate host, the raccoon, Procyon lotor. Journal of Parasitology 88(6):1151-1158.

38) Sofaly, C.S., Reed, S.M., Gordon, J.C., Dubey, J.P., Oglesbee, M.J., Njoku, C.J., Grover, D.L., Saville, W.J.A. (2002). Experimental induction of equine protozoal myeloencephalitis (EPM) in the horse: effect of Sarcocystis neurona sporocyst inoculation dose on the development of clinical neurologic disease. Journal of Parisitology 88:1164-1170.

39) Oglesbee, M.J., Pratt, M., Carsillo, T. (2002). A role for heat shock proteins in the immune response to measles virus infection. Viral Immunology 15(3):399-416. PMID: 12479391

40) Kim, J.Y., Sun, Q., Oglesbee, M., Yoon, S.O. (2003). The role of ErbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo. Journal of Neuroscience 23(13):5561-71.

41) Zhang, X., Oglesbee, M. (2003). Use of surface plasmon resonance for the measurement of low affinity binding interactions between hsp72 and the measles virus nucleocapsid protein. Biological Procedures Online 5(1):170-181.

42) Krakowka, S., Ellis, J., McNeilly, F., Meehan, B., Oglesbee, M., Alldinger, S., Allan, G. (2004). Features of Cell Degeneration and Death in Hepatic Failure and Systemic Lymphoid Depletion Characteristic of Porcine Circovirus-2-Associated Postweaning Multisystemic Wasting Disease.  Veterinary Pathology 41:471-481.

43) Carsillo, T., Carsillo, M., Niewiesk, S., Vasconcelos, D., Oglesbee, M. (2004). Hyperthermic pre-conditioning promotes measles virus clearance from brain in a mouse model of persistent infection. Brain Research 1004:73-82.

44) Van Biervliet, J., de Lahunta, A., Ennulat, D., Oglesbee, M., Summers, B. (2004). Acquired cervical scoliosis in six horses associated with dorsal grey column chronic myelitis. Equine Veterinary Journal 36(1): 86-92.

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45) Saville, W.J., Dubey, J.P., Oglesbee, M.J., Sofaly, C.D., Marsh, A.E., Elitsur, E., Vianna, M.C., Lindsay, D.S., Reed, S.M. (2004). Experimental infection of ponies with Sarcocystis fayeri and differentiation from Sarcocystis neurona infections in horses. Journal of Parasitology 90(6): 1487-91.

46) Saville, W.J., Sofaly, C.D., Reed, S.M., Dubey, J.P., Oglesbee, M.J., Lacombe, V.A., Keene, R.O., Gugisberg, K.M., Swenson, S.W., Shipley, R.D., Chiang, Y.W., Chu, H.J., Ng, T. (2004). An equine protozoal myeloencephalitis challenge model testing a second transport after inoculation with Sarcocystis neurona sporocysts. Journal of Parasitology 90(6): 1406-10.

47) Threlfall, W.R., Robertson, J.T., Munsterman, A.S., Oglesbee, M.J., Hubbell, J.A. (2005). Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor. Journal of the American Veterinary Medical Association 226(10):1649-50.

48) Zhang, X., Bhouris, J.-M., Longhi, S., Carsillo, T., Buccellato, M., Morin, B., Canard, B., Oglesbee, M. (2005). Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus. Virology 337:162-174.

49) Bourhis, J.-M., Receveur-Bréchot, V., Oglesbee, M., Zhang, X., Buccellato, M., Darbon, H., Canard, B., Finet, S., Longhi, S. (2005). The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded. Protein Science 14(8):1975-92.

50) Oglesbee, M.J., Herdman, A.V., Passmore, G.G., Hoffman, W.H. (2005). Diabetic ketoacidosis increases extracellular levels of the major inducible 70 kDa heat shock protein. Clinical Biochemistry 38(10):900-4.

51) Carsillo, T., Zhang, X., Vasconcelos, D., Niewiesk, S., Oglesbee, M. (2006). A single codon in the nucleocapsid protein C-terminus contributes to in vitro and in vivo fitness of Edmonston measles virus. Journal of Virology 80(6): 2904-2912.

52) Carsillo, T., Traylor, Z., Choi, C., Niewiesk, S., Oglesbee, M. (2006). Hsp72, a host determinant of measles virus neurovirulence. Journal of Virology 80(22):11031-11039.

This article was selected for the Spotlight section, Journal of Virology, and the Journal Highlights section of Microbe, a news publication for the American Society for Microbiology (ASM). Journal Highlights summarizes the six best ASM Journal Articles for the month (from a total of 11 journals).

53) Wünschmann, A., Armien, A., Wallace, R., Wictor, M., Oglesbee, M. (2006). Neuronal storage disease in a group of captive Humboldt penguins (Spheniscus humboldti). Veterinary Pathology 43(6):1029-1033.

54) McDowell, H., Lindstrom, J.G., Oglesbee, M. (2006). Communicating hydrocephalus in a mature Goffin’s cockatoo (Cactua goffini). Journal of Avian Medicine and Surgery 20(3):180-184.

55) Hassantoufighi, A., Oglesbee, M., Richter, B.W.M., Prince, G.A., Hemming, V., Niewiesk, S., Eichelberger, M.C. (2007). Respiratory syncytial virus replication is prolonged by a concomitant allergic response. Clinical and Experimental Immunology 148:218-229.

56) Hoffman, W.H., Casanova, M.F., Cudrici, C.D., Zakranskaia, E., Venugopalan, R., Nag, S., Oglesbee, M.J., Rus, H. (2007). Neuroinflammatory response of the choroid plexus epithelium in fatal diabetic ketoacidosis. Experimental and Molecular Pathology 83(1):65-72.

57) Elitsur, E., Marsh, A.E., Reed, S.M., Dubey, J.P., Oglesbee, M.J., Murphy, J.E.,

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Saville, W.J.A. (2007). Early migration of Sarcocystis neurona in ponies fed sporocysts. Journal of Parasitology 93(5): 1222-1225.

58) delos Santos, J.R.C., Boughan, K., Bremer, W.G., Rizzo, B., Schaefer, J.J., Rikihisa, Y., Needham, G.R., Capitini, L.A., Anderson, D.E., Oglesbee, M., Ewig, S.A., Stich, R.W. (2007). Experimental infection of dairy calves with Ehrlichia chaffensis. Journal of Medical Microbiology 56:1660-1668.

59) Lairmore, M.D., Oglesbee, M., Weisbrode, S.E., Wellman, M., Rosol, T., Stromberg, P. (2007). Developing and fostering a dynamic program for training in veterinary pathology and clinical pathology: veterinary students to post-graduate education. Journal of Veterinary Medical Education 34(4): 464-472.

60) Coates, J.R., March, P.A., Oglesbee, M., Ruaux, C.G., Olby, N.J., Berghaus, R.D., O’Brien, D.P., Keating, J.H., Johnson, G.S., Williams, D.A. (2007). Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs. Journal of Veterinary Internal Medicine 21:1323–1331.

61) Awad, H., Suntres, Z., Heijmans, J., Smeak, D., Bergdall-Costell, V., Cristofi, F.L., Magro, C., Oglesbee, M. (2008). Intracellular and extracellular expression of the major inducible 70 kDa heat shock protein in experimental ischemia-reperfusion injury of the spinal cord. Experimental Neurology 212:275-284.

62) Hurcombe, S.D.A., Slovis, N.M., Kohn, C.W., Oglesbee, M. (2008). Poorly differentiated leiomyosarcoma of the urogenital tract in a two year old thoroughbred filly. Journal of the American Veterinary Medical Association 233(12):1908-1912.

63) delos Santos, J.R., Oglesbee, M., Rikihisa, Y., Stich, R.W. (2008). Pathological evidence of ehrlichiosis in calves inoculated with Ehrlichia chaffeensis. Animal Biodiversity and Emerging Diseases 1149:1003-106.

64) March, P.A., Coates, J.R., Abyad, R., Williams, D.A., O’Brien, D., Olby, N.J., Keating, J.H., Oglesbee, M. (2009). Degenerative myelopathy in 18 Pembroke Welsh Corgi dogs. Veterinary Pathology 46(2):241-250.

65) Carsillo, T., Carsillo, M., Traylor, Z., Rajala-Schultz, P., Popovich, P., Niewiesk, S., Oglesbee, M. (2009). Major histocompatibility complex haplotype determines hsp70-dependent protection against measles virus neurovirulence. Journal of Virology 83(11):5544-5555. PMC2681930

66) Rosol, T., Moore, R., Saville, W., Oglesbee, M., Rush, L., Mathes, L., Lairmore, M. (2009). The need for veterinarians in biomedical research. Journal of Veterinary Medical Education 36(1):70-75.

67) Couturier, M., Buccellato, M., Costanzo, S., Bourhis, J.M., Shu, Y., Nicaise, M., Desmadrill, M., Flaudrops, C., Longhi, S., Oglesbee, M. (2010). High affinity binding between hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an hsp40 co-chaperone. Journal of Molecular Recognition 23(3):301-15.

68) Longhi, S., Oglesbee, M. (2010). Structural disorder within the measles virus nucleoprotein and phosphoprotein. Protein and Peptide Letters 17(8):961-78.

69) Martin-Vaquero, P., da Costa, R., Aeffner, F., Oglesbee, M., Echandi, R. (2010). Imaging diagnosis – hemorrhagic meningioma. Veterinary Radiology and Ultrasound 51(2):165-7.

70) Anderson, D.E., Couto, C.G., Oglesbee, M. (2010). Granulosa theca cell tumor with erthrocytosis in a llama. Canadian Veterinary Journal 51(10):1157-60.

71) Martin-Vaquero, P., Moore, S.A., Wolk, K.E., Oglesbee, M.J. (2011). Cerebral vascular hamartoma in a geriatric cat. Journal of Feline Medicine and Surgery 13(4):286-90 PMC4270697

72) Oglesbee, M., Niewiesk, S. (2011). Measles virus neurovirulence and host immunity.

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Future Virology 6(1):85-99. 73) Kim, D., Huey, D., Oglesbee, M., Niewiesk, S. (2011). Insights into the regulatory

mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies. Blood 117(23):6143-51.

74) Habchi, J., Blangy, S., Mamelli, L., Jensen, M.R., Blackledge, M., Darbon, H., Oglesbee, M., Shu, Y., Longhi, S. (2011). Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus. Journal of Biological Chemistry 286(15):13583-602.

75) Moore, S., Kim, M.Y., Maiolini, A., Tipold, A., Oglesbee, M. (2012). Extracellular hsp70 release in canine steroid responsive meningitis-arteritis. Veterinary Immunology and Immunopathology 145(1-2):129-33.

76) Martin-Vaquero, P., da Costa, R., Wolk, K., Premanandan, C., Oglesbee, M. (2012). MRI features of gliomatosis cerebri in a dog. Veterinary Radiology and Ultrasound 53(2):189-192 PMC4270696

77) Martin-Vaquero, P., da Costa, R., Simmons, J., Beamer, G., Jäderlund, K., Oglesbee, M. (2012). A novel spongiform leukoencephalomyelopathy in border terrier puppies. Journal of Veterinary Internal Medicine 26(2):402-6.

78) Shu, Y., Habchi, J., Costanzo, S., Padilla, A., Brunel, J., Gerlier, D., *Oglesbee, M., *Longhi, S. (2012). Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus. Journal of Biological Chemistry 287(15):11951-67.

* co-senior authors79) Brooks, A.N., Brooks, K.N., Oglesbee, M. (2012). A suprasellar germ cell tumor in a

16-month old Wagyu heifer calf. Journal of Veterinary Diagnostic Investigation 24(3):587-90. PMC4272009

80) Moore, S., Oglesbee, M. (2012). Involvement of the choroid plexus in the inflammatory response after spinal cord injury in dogs: an immunohistochemical study. Veterinary Immunology and Immunopathology 148(3-4):348-52. PMC4221256

81) Blocquel, D., Habchi, J., Costanzo, S., Doizy, A., Oglesbee, M., Longhi, S. (2012). Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: a tight complex involving one binding site. Protein Science 21(10):1577-85

82) Kim, M.Y., Shu, Y., Carsillo, T., Zhang, J., Yu, L., Peterson, C., Longhi, S., Girod, S., Niewiesk, S., Oglesbee, M. (2013). Hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain. Journal of Virology 87(2):998.

This article was featured in World Biomedical Frontiers, founded in 2012 and headquartered in New York (USA). The mission of this on-line resource is to serve as a platform for exchange of the latest research progress and groundbreaking discoveries in biomedical science. The goals are to enlighten the community of the latest innovative ideas in biomedical research and to draw public attention to promising findings in preclinical basic research, expediting their entry into the pipeline that may lead to development of new therapies. See http://biomedfrontiers.org/infection-2013-11-4/

83) Kovi, R., Wuenschmann, A., Armien, A., Hall, K., Carlson, T., Shivers, J., Oglesbee, M. (2013). Spinal meningeal oligodendrogliomatosis in two boxer dogs. Veterinary Pathology 50(5): 761-764.

84) Price, R.L., Song, J., Bingmer, K., Kim, T.H., Yi, J.Y., Nowicki, M.O., Hollon, T., Murnan, E., Alvarez-Breckenridge, C., Fernandez, S., Kaur, B., Rivera, A.,

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Oglesbee, M., Cook, C., Chiocca, E.A., Kwon, C.H. (2013). Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Research 73(11):3441-50. PMC4136413

85) Kim, M.Y., Ma, Y., Zhang, Y., Li, J., Shu, Y., Oglesbee, M. (2013). Hsp70-dependent antiviral immunity against cytopathic neuronal infection by vesicular stomatitis virus. Journal of Virology 87(19):10668-10678. PMC3807379

86) Ma, Y., Wei, Y., Zhang, X., Zhang, Y., Cai, H., Zhu, Y., Shilo, K., Oglesbee, M., Krakowka, S., Whelan, S., Li, J. (2014). mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo. Journal of Virology 88(5):2913-26.

87) Oglesbee, B., Lightner, B., Oglesbee, M. (2014). Coelomic granulomatous fat necrosis (lipogranulomatosis) in an umbrella cockatoo (Cacatua alba). Journal of Avian Medicine and Surgery 28(3):242-250.

88) Ma, Y., Duan, Y., Wei, Y., Liang, X., Niewiesk, S., Oglesbee, M., Li, J. (2014). Heat shock protein 70 enhances mucosal immunity against human norovirus when co-expressed from a vesicular stomatitis viral vector. Journal of Virology 88(9):5122-37.

89) Lovett, M.C., Coates, J., Shy, Y., Oglesbee, M.J., Fenner, W., Moore, S.A. (2014). Quantitative assessment of hsp70, IL-1β and TNF-α in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy. Veterinary Journal 200(2):312-7.

90) Schneider, C.P., Ishihara, A., Adams, T.P., Zekas, L.J., Oglesbee, M., Bertone, A.L. (2014). Analgesic effects of intraneural injection of ethyl alcohol or formaldehyde in the palmar digital nerves of horses. American Journal of Veterinary Research 75(9):784-91.

91) Berman-Booty, L.D., Thomas-Ahner, J.M., Bolon, B., Oglesbee, M.J., Clinton, S.K., Kulp, S.K., Chen, C.S., LaPerle, K.M. (2015). Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicologic Pathology 43(2):186-97. PMC4201646

92) Moore, S.A., Oglesbee, M. (2015). Spinal cord ependymal responses to naturally occurring traumatic spinal cord injury in dogs. Veterinary Pathology 52(6):1108-1117.

93) Ma, Y., Zhang, Y., Liang, X., Lou, F., Oglesbee, M., Krakowka, S. Li, J. (2015). Origin, evolution and virulence of a novel porcine deltacoronavirus in the United States. mBio 6(2): e00064-15

94) Chawla, P., Cook, L., Himmell, L., Zekas, L., Oglesbee, M. (2015). Coextensive meningioma and cholesterol granuloma in the forebrain of a cat. Journal of Veterinary Internal Medicine 29(6):1638-1642. PMC4852139

95) Ma, Y., Zhang, Y., Liang, X., Oglesbee, M., Krakowka, S., Niehaus, A., Wang, G., Jia, A., Song, H., Li, J. (2016). Two-way antigenic cross-reactivity between epidemic diarrhea virus and porcine deltacoronavirus. Veterinary Microbiology 186:90-96.

96) Himmel, L.E., Song, R.B., da Costa, R.C., Oglesbee, M. (2017). Pathology in Practice. Journal of American Veterinary Medical Association 250(1):55-58.

97) Saville, W., Reed, S., Dubey, J.P., Marsh, A., Keene, R., Morrow, J., Oglesbee, M., Wittum, T. (2018). Testing the Sarcocystis neurona vaccine using an equine protozoal myeloencephalitis challenge model. Veterinary Parasitology (in press).

98) Cook, L., Tensley, M., Drost, T., Koivisto, C., Oglesbee, M. (2018). MRI findings of suprasellar germ cell tumor in two dogs. Journal of the American Animal Hospital Association (in press).

H Index: 27

B) Journal Articles – Editor Reviewed

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1) Podell, M., March, P., Buck, W., Hayes, K., Oglesbee, M., Steigerwald, E., Mathes, L. (1998). The feline model of Neuro-AIDS (Part 1). NeuroAIDS (On-Line) 1(8): www.sciencemag.org/NAIDS.

2) Podell, M., March, P., Buck, W., Hayes, K., Oglesbee, M., Steigerwald, E., Mathes, L. (1999). The feline model of Neuro-AIDS (Part 2). NeuroAIDS (On-Line) 2(1): www.sciencemag.org/NAIDS.

3) Buccellato, M., Carsillo, T., Oglesbee, M. (2007). Heat shock protein expression in brain: a protective role spanning intrinsic thermal resistance to host defense against neurotropic viruses. Progress in Brain Research 162:395-415. PMID: 17645929

4) Uhl, E.W., Whitley, E., Galbreath, E., McArthur, M., Oglesbee, M. (2012). Evolutionary aspects of animal models. Veterinary Pathology 49(5):876-878. PMID:22983990

5) Kim, M.Y., Oglesbee, M. (2012) Virus-Heat Shock Protein Interaction and a Novel Axis for Innate Antiviral Immunity. Cells 1:646-666. PMID: 24710494

6) Oglesbee, M., Labranche, T. (2013). Inside-out: extracellular roles for heat shock proteins. Veterinary Pathology 50(5): 921-924. PMID: 23839234

C) Book Chapters

1) Oglesbee, M. (2007). Nucleocapsid Interactions with the major inducible 70 kDa heat shock protein. In: Longhi, S. (Editor), Measles Virus Nucleoprotein. Nova Scientific Publishers, Inc., Hauppauge NY.

2) Niewiesk, S., Oglesbee, M. (2013). Paramyxoviridae, Filoviridae, and Bornaviridae. In: McVey, D.S., Kennedy, M., and Chengappa, M.M. (Editors), Veterinary Microbiology, 3rd Edition. Wiley-Blackwell, Ames, Iowa.

3) Oglesbee, M., Niewiesk, S. (2016). Pathogenesis of Viral Infections and Diseases. In: MacLachlan, N.J., and Dubovi, E.J. (Editors), Fenner’s Veterinary Virology, 5 th

Edition. Elsevier, San Diego, CA.4) Oglesbee, M., Kim, M.Y., Shu, Y., Longhi, S. (2018). Extracellular Hsp70,

Neuroinflammation and Protection against Viral Virulence. In: Asea, A.A., and Kaur, P. (Editors), Chaperokine Activity of Heat Shock Proteins. Springer Nature International Publishers, Dordrecht, Netherlands.

D) Other Publications

Oglesbee, M.J. A review of Cellular Responses to Stress, edited by C.P. Downes, C.R. Wolf, D.P. Lane, Princeton University Press, Princeton, New Jersey. Review published in the Quarterly Review of Biology 75(4):454 (2000).

III) RESEARCH FOCUS

The cellular stress response is characterized by the production of heat shock proteins (HSP) that mediate cell recovery from and protection against potentially lethal injury. This protective role is well documented in metabolic, degenerative, and ischemic brain injury, but our group was the first to address how these same HSP influence a virus’ ability to spread and cause disease in the nervous system.

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Research performed in my laboratory showed that the major inducible 70 kDa heat shock protein (hsp70) is induced by and supports intracellular replication of viruses belonging to diverse families, with specific focus on measles and canine distemper virus (paramyxoviruses) and vesicular stomatitis virus (a rhabdovirus). Paradoxically, this virus-hsp70 interaction is protective in mouse models of viral neurovirulence, enhancing T cell mediated immune clearance in an interferon β (IFN-β)-dependent manner. Protection reflects early release of hsp70 from viable infected neurons and induction of strong innate immune responses in uninfected brain macrophages, including the induction of IFN-β through Toll-like receptor 4. Potency of the response is inherent in the fact that hsp70 is released at a time when pathogen-associated molecular patterns (PAMPs) are in low abundance, and that the innate response is driven by uninfected cells, free from viral interference. Release of hsp70 from viable cells is primarily exosomal, and infection enhances total exosome release and hsp70 content on the surface of exosomes. Exosome content of hsp70 reflects levels of hsp70 in the infected cell. Findings have broad virological relevance and support a protective role for fever, a potent stimulus for hsp70 induction. While protective in the context of microbial infection, recent findings support potential untoward effects of inappropriate extracellular hsp70 release in non-infectious neuroinflammatory conditions.

Ongoing focus/interests: relevance of the hsp70-TLR4 immune axis to protection against other neurovirulent viruses mechanisms regulating extracellular release of hsp70 in virus infection the role of extracellular hsp70 in neuroinflammatory responses in both infectious and non-

infectious diseases novel uses of hsp70 as a vaccine adjuvant for viral infections

Additional collaborative research support is provided in the general areas of neurovirology and neuropathology.

IV) FUNDING HISTORY

A) Extramural Research Funding as Principal Investigator

17 years of NIH support on NS 31693 and 2 years on AI 7811

1) Title: In Vitro and In Vivo Persistence of Canine Distemper VirusSponsor: NIH, NIAID, National Research Service Award (NRSA)

F32 AI07811Duration: 9/1/88 - 8/31/90Direct Costs: $52,750

2) Title: Small Instrumentation GrantSponsor: NIH, National Institute of Diabetes and Digestive and Kidney

Diseases, Small Instrumentation Grant ProgramDuration: 8/1/92 - 7/31/93Direct Costs: $13,456

3) Title: The Interaction between Bovine Respiratory Syncytial Virus and theCellular Stress Response

Sponsor: USDA, Formula FundsDuration: 1/1/94 - 9/30/94Direct Costs: $14,925.70

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4) Title: The Cellular Stress Response in Viral EncephalitisSponsor: NIH, NINDS, First Independent Research and Transition Award

R29 NS31693Duration: 7/1/94 - 6/30/99Direct Costs: $444,914.00

5) Title: The Cellular Stress Response in Viral Encephalitis Sponsor: NIH, NINDS, Research Career Development Award (RCDA)

K04 NS01798Duration: 4/1/95 - 3/31/2000Direct Costs: $250,000

6) Title: The Cellular Stress Response in Viral Encephalitis Sponsor: NIH, NINDS

Supplement for Research Infrastructure (NS 31693-05S1)Duration: 04/01/99 - 03/31/2000Direct Costs: $25,000

7) Title: The Cellular Stress Response in Viral Encephalitis Sponsor: NIH, NINDS

R01 (NS 31693) Duration: 04/01/00 - 03/31/06

Total Costs: $1,104,000 (direct + indirect)

8) Title: The Cellular Stress Response in Viral Encephalitis Sponsor: NIH, NINDS

R01 (NS 31693 11-13) Duration: 07/15/06 - 06/30/11 (includes two no-cost extensions)Total Costs: $693,720 (direct + indirect)

Collectively, this project (The Cellular Stress Response in Viral Encephalitis,NS 31693) ran from 07/01/1994 through 6/30/2011

Total direct costs: $1,883,233Total F&A: $744,747Total Award: $2,627,980

9) Title: Heat Shock Protein Modulation of Paramyxoviral DiseaseSponsor: NIH, National Institute of Allergy and Infectious Disease

R21 (AI 71174)Duration: 02/01/08 - 01/31/11Total Costs: $412,500 (direct + indirect)

10) Title: Facilities Improvement for Infectious Disease ResearchSponsor: NIH, National Center for Research Resources

C06 (RR020088)Duration: 10/20/2009 – 10/19/2014Total Costs: $3,920,956

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Note: This grant was originally awarded to Dr. Michael Lairmore with transfer of PI status in September 2011.

11) Title: The pathogenesis and characterization of porcine epidemic diarrheavirus (PEDV) and porcine delta coronavirus (PEdCV) in neonatal gnotobiotic swine.

Sponsor: National Pork Board, NPB Project #14-188Duration: 7/1/2014-12/30/2014Total Costs: $34,394

12) Title: Pathology Services (evaluation of a viral oncolytic therapy for glioblastoma multiforme)

Sponsor: OncorusDuration: 2/14/2018-2/13/2019Total Costs: $20,000

B) Intramural Research Funding as Principal Investigator

1) Title: Canine Distemper Viral Gene-Specific Probes: Synthesis and Application

Sponsor: The State of Ohio Canine Research FundsDuration: 12/9/85 - 12/9/87Direct Costs: $7,100

2) Title: Canine Distemper Viral Nucleocapsid-Shock Protein InteractionSponsor: The State of Ohio Canine Research FundsDuration: 12/29/89 - 12/29/92Direct Costs: $20,000

3) Title: Tissue Expression of Heat Shock Protein as an In Vivo Determinant of the Outcome of Canine Distemper Virus (CDV) Infection

Sponsor: The State of Ohio Canine Research FundsDuration: 6/26/92 - 12/30/93Direct Costs: $16,880

4) Title: Interaction of Canine Distemper Virus Nucleocapsid with 70 Kilodalton Heat Shock Proteins

Sponsor: The Ohio State University Seed GrantDuration: 2/28/90 - 2/28/92Direct Costs: $13,000

5) Title: Inhibition of Heat Shock Protein Expression as a Novel Antiviral Strategy

Sponsor: The State of Ohio Canine Research FundsDuration: 3/1/94 - 2/28/96Direct Costs: $11,974.00

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6) Title: Identification of Cellular Kinases Required for Canine Distemper Virus Replication

Sponsor: The State of Ohio Canine Research FundsDuration: 3/01/96 - 2/28/98Direct Costs: $11,266

7) Title: Peritoneal Lavage Whole Body Hyperthermia in the Dog Sponsor: The State of Ohio Canine Research FundsDuration: 7/01/97 - 6/30/99Direct Costs: $12,000

8) Title: Morbillivirus Nucleocapsid Determinant(s) of Structural andFunctional Interactions with 72 kDa Heat Shock Protein

Sponsor: State of Ohio Canine Research FundsDuration: 07/01/1999 - 6/30/2000Direct Costs: $11,990

9) Title: Reservoir competency of the soft tick Ornithodoros kelleyi for highlands J virus, an alphavirus related to eastern and western equine encephalitis virus.

Sponsor: Ohio Racing Commission, Equine Research FundsDuration: 6/01/03 - 5/31/05Direct Costs: $19,712

10) Title: Modulation of the Morbilliviral Response to the 72 kDa Heat Shock Protein

Sponsor: The State of Ohio Canine Research Funds (OSU-520168)Duration: 6/01/03 - 5/31/05Direct Costs: $20,000

11) Title: Hsp70 mediated protection against viral neurovirulenceSponsor: The State of Ohio Canine Research Funds Duration: 8/1/2012-7/31/2014Direct Costs: $22,317

C) Extramural Research Funding as Co-Investigator

1) Title: LSM-410 Inverted Spot Laser Scanning Confocal Microscope.Sponsor: National Center for Shared Resources, NIH, Shared Instrumentation

GrantPI: Fedias ChristophiDuration: 4/96 - 3/97Direct Costs: $293,725

2) Title: Evaluation of the Trillium Health Center Computer Assisted

Hyperthermia System in the Canine ModelSponsor: iP Scientific, Inc.PI: Richard TallmanDuration: 2/15/96 - 2/14/97

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Direct Costs: $58,725

3) Title: Measuring molecular binding by surface plasmon resonanceSponsor: NCRR Shared Instrumentation GrantPI: Charles BrooksDuration: 4/01/01 - 3/31/02Direct Costs: $260,000

4) Title: Equine protozoal myeloencephalopathy vaccine

Sponsor: Fort DodgePI: William SavilleDuration: 9/01/02 - 5/31/03Direct Costs: $50,000

5) Title: Measurement of Cells In Vivo: IVIS Light Imaging SystemSponsor: NCRR Shared Instrumentation Grant, NIHPI: Tom RosolDuration: 04/01/03 - 03/31/04Direct Costs: $169,950

6) Title: Efficacy studies of Sarcocystis neurona vaccineSponsor: Fort DodgePI: Bill SavilleDuration: 09/01/03 - 03/31/05Direct Costs: $395,406

7) Title: BAALC in neurogenesis and hematopoiesis Sponsor: National Institutes of Health

R01 CA098933PI: Albert de la ChapelleDuration: 7/01/04 - 4/30/08Direct Costs: $1,250,000Effort: 5%

8) Title: Preclinical Toxicity Evaluation of a Potent Oncolytic Virus Sponsor: NIH, NINDS

U01 NS061811PI: Nino ChioccaDuration: 9/30/2008 - 8/31/2013Total costs: $2,554,603 (direct and indirect through year 3 of 5)Effort: 5%

9) Title: Equine head trauma: Correlation of neuroanatomic skull injury andbrain damage using state of the art 3T MR, contrast CT and immunohistochemical analysis.

Sponsor: American Quarter Horse AssociationPI: Margaret MudgeDuration: 10/01/08 - 9/30/09Direct Costs: $73,596

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Effort: not specified

10) Title: Nanoparticles and nanocapsules for glioma targetingSponsor: NIH, National Cancer Institute

R44 (Phase II SBIR) CA135906PI: Ruben SpretzDuration: 9/1/2011 – 8/31/2014Total Costs: $666,667 (FY 2011)Effort: 5%

11) Title: The role of hsp70, IL-1β and TNFα responses in recovery after canine spinal cord injury

Sponsor: Gray Lady FoundationPI: Sarah MooreDuration: 10/31/2011-10/30/2013Direct Costs: $16,660Effort: not specified

D) Intramural Research Funding as Co-Investigator

1) Title: The Neuropathogenesis of Feline Immunodeficiency Virus: Topographic Distribution and Cellular Distribution in Neonatal and Adult Cat Brain

Sponsor: The Ohio State University, Seed GrantPI: Michael PodellDuration: 4/1/95 - 3/31/97Direct Costs: $20,000

2) Title: Transarterial Embolization as a Treatment of Meningioma in DogsSponsor: State of Ohio Canine Research FundsPI: Renee LeveilleDuration: 2/1/00 - 1/31/01Direct Costs: $14,899

3) Title: Vesicular stomatitis virus as the vector to deliver human Norovirus-likeparticles: a new vaccine strategy against non-cultivatable foodborne viruses

Sponsor: PHPID, The Ohio State University (Pilot Research Grant Program)PI: Jianrong Li (College of Food, Agriculture and Environmental

Sciences)Duration: 10/1/2008 - 9/30/2010Direct Costs: $100,000

E) Director/Mentor on Training Grants/Fellowships – Extramural Funding

1) Title: Stress Protein Modulation of Measles Virus EncephalitisSponsor: NIH/NINDS, Mentored Clinical Scientist Development Award

K08 NS01906

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Mentee/PI: Daphne VasconcelosDuration: 09/01/98 - 08/31/01Direct Costs: $241,536

2) Title: Modulation of the morbilliviral response to Hsp72Sponsor: NIH, NIAID

K08 AI057746Mentee/PI: Matt BuccellatoDuration: 07/01/04 - 03/31/08Direct Costs: $397,913 (from PI portal)

3) Title: Na+ transport inhibition by respiratory syncytial virus Sponsor: NIH, NCRR

K01 RR017626Mentee/PI: Ian DavisDuration: 08/01/06 - 07/31/08Direct Costs: $242,550 (from PI portal)

4) Title: Short Term Research Training for Veterinary Students Sponsor: NIH, NCRR (now Office of Research Infrastructure Programs, ORIP)

T35 RR021310PI: Michael OglesbeeDuration: 4/01/09 - 12/31/2013Direct Costs: $312,150 (total)

Renewal: 5/01/2014-3/31/2019Direct Costs: $333,450 (total)

5) Title: Mouse Pathobiology: Models of Human DiseaseInstitutional National Service Research Award

Sponsor: NIH, NCRR/ORIPT32OD010429

PI: Thomas Rosol/Michael Oglesbee (Co-Director)Duration: 04/01/2012 – 03/31/2017 (years 11-15)Direct Costs: $1,663,812

Title: Supplement, Institutional Allowance, Mouse Pathobiology: models of human disease

Sponsor: NIH, ORIPPI: Thomas Rosol/Michael OglesbeeDuration: 8/15/2017-03/31/2018Direct Costs: $240,112

F) Mentor on Graduate Fellowships – Intramural Funding

1) Title: Amino Acid Determinants of the Interaction between Paramyxovirus Nucleocapsid and Heat Shock Proteins

Sponsor: College of Veterinary Medicine and the Barber Trust.Mentee/PI: Daphne Vasconcelos

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Duration: 9/1/94 - 9/1/97Direct Costs: $76,652.00

2) Title: Amino Acid Composition of the HSP Binding Motif on the Morbillivirus

Nucleocapsid Protein: a Determinant of Viral Stress-ResponsivenessSponsor: College of Veterinary Medicine and the Barber Trust Mentee/PI: Xinsheng ZhangDuration: 07/01/02 - 06/30/05Direct Costs: $63,288

3) Title: Modulation of the Morbilliviral response to Hsp72Sponsor: College of Veterinary Medicine and the Barber Trust Mentee/PI: Matthew BuccellatoDuration: 07/01/03 - 06/30/04Direct Costs: $28,000

4) Title: Heat shock protein-TLR4 interaction as a basis for antiviral immunitySponsor: College of Veterinary Medicine and the Barber Trust Mentee/PI: Mi Young KimDuration: 7/01/2010 – 6/30/2013Direct Costs: $76,308

G) Co-investigator on Funded Training Grants

6) Title: NCRR Training Grant for Veterinary Students in Animal-Oriented, Hypothesis Based Research

Role on Project: Co-investigatorPI: Michael LairmoreSponsor: National Center for Research Resources, National Institutes of HealthDuration: 12/1/02-11/30/05Direct Costs: $201,031

V) TEACHING

A) Graduate Student Advising

1) Masters Student Advisor

Completed (n = 7):

Hai Kenney MS, DO 1991-1993, Veterinary PathobiologyThesis: Assessment of Cell-Free Transcription by the Canine Distemper Virus Nucleocapsid

Matt Heller DVM, MS (combined DVM/MS program)1995-1998, VBSThesis: Interferon-α Inhibits the Emergence of Cellular Stress Response-Dependent Morbillivirus Large Plaque Variants

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Awards based upon graduate work: Financial support from the Summer Graduate Aid Enrollment

Program, College of Veterinary Medicine (1995, 1996)

Kate Diehl DVM, MS (combined DVM/MS program) 1996-1999, VBSThesis: Alterations in Hemostasis Associated with Hyperthermia in a Canine ModelAwards based upon graduate work:

Financial support from the Summer Graduate Aid Enrollment Program, College of Veterinary Medicine (1997, 1998)

Mary Pratt DVM (combined DVM/MS program)2000-2003, VBS

Entered the anatomic pathology residency at The Ohio State University

Heather Miller DVM, MS (combined DVM/MS program)2003-2006, VBSThesis: Measles virus induced 70 kDa heat shock protein enhances cell permissiveness to infectionAwards based upon graduate work:

Second Place Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Veterinary Student category), College of Veterinary Medicine, The Ohio State University (2004)

Second Place Award for winter quarter research seminar presentation (Roche Distinguished Graduate Student Award competition), Department of Veterinary Biosciences, The Ohio State University (2005)

Yaoling Shu, MS 2005-2007, MCDBThesis: Measles virus core protein determinants of viral gene expressionAwards based upon graduate work:

Travel Award (one of two) for poster presentation at the Advances in Veterinary Medicine Research colloquium (Immunology and Infectious Disease category), College of Veterinary Medicine, The Ohio State University (2007).

Pamela Lee (combined DVM/MS program)2005-2008, VBSThesis: Heat shock protein responsiveness of wild type measles virus isolates

2) Masters Students Committee Member

Completed (n = 11):

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Mark Pollman DVM, MS1989-1991, Veterinary Pathobiology (Lawrence Mathes, advisor)Thesis: Characterization of Immunodominant Proteins of Chronically Infected HTLV-1 Cell Lines

Joshua Bartoe DVM, MS (combined DVM/MS program) 1998-2001, VBS (Michael Lairmore, advisor)Thesis: Studies of Human T-Lymphotrophic Virus Type-1 pX ORF II in a Rabbit Model of Infection

Cheryl Sofaly DVM, MS2001-2003, VPM (William Saville, advisor)Thesis: Development of an Equine Model for Protozoal Myeloencephalitis

Jon Stanek (combined DVM/MS program)2001-2004, VPM (William Saville, advisor)Thesis: Investigation and Epidemiology of Intermediate Host Species in the Life Cycle of Sarcocystis neurona

Weichao Bao, MS2005-2007, VBS (Yasuko Rikihisa, advisor)Thesis: Type IV secretion system of Ehrlichia chaffeensis

Einav Elitsur (combined DVM/MS program) 2004-2007, VPM (William Saville, advisor)Thesis: Early migration of Sarcocystis neurona in ponies fed sporocysts

Matthew Blanchong (combined DVM/MS program) 2003-2007, VBS (Stefan Niewiesk, advisor)Thesis: Role of heat shock protein (HSP) 72 in measles virus replication.

Kendra Wolk, DVM2011-2012 (Ian Davis, advisor)Thesis: Influenza A virus inhibits alveolar fluid clearance in Balb/c mice.

Elizabeth Dryburgh2012, VPM (Bill Saville, advisor)Thesis: Identification of different strains of Sarcocystis neurona merozoites.

Christine Pariseau Schneider2013, VCS (Alicia Bertone, advisor)Thesis: Relative potency and duration of analgesia following palmar digital intra-neural alcohol injection for heel pain in horses.

Matthew Lovett, DVM2013 (Sarah Moore, advisor)The role of hsp70, IL-1 beta and TNF-alpha in Canine Degenerative Myelopathy, a spontaneous model of amyotrophic lateral sclerosis

3) Doctoral Student Advisor

Completed (n = 5):

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Daphne Vasconcelos DVM, PhD 1995-2000, VBSDissertation: The Cellular Stress Response in Measles Virus EncephalitisAwards based upon graduate work:

Fellowship through the Barber Charitable Trust, The Ohio State University college of Veterinary Medicine (1994-1997)

Third Place award for presentation in the Biological Sciences, 11th Annual Graduate Research Forum, The Ohio State University (1997).

Travel Grant from Women in Science, awarded through the Committee on Institutional Cooperation’s Women in Science and Engineering Initiative, The Ohio State University (1997)

Young Investigator Award in Experimental Pathology (First Place), American College of Veterinary Pathologists, awarded at the 49th annual meeting, St. Louis, MO (1998)

NIH K08 Award (NINDS) (1998-2001)Current Position:

Manager of Pathology, Battelle Memorial Institute, Columbus, OH (2007-2017)

Xinsheng Zhang PhD 1999-2004, VBSDissertation: Structural and Functional Interactions between Measles Virus Nucleocapsid Protein and Cellular Heat Shock Protein.Awards based upon graduate work:

Second Place Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Structure & Function category), College of Veterinary Medicine, The Ohio State University (2001)

Fellowship through the Barber Charitable Trust, The Ohio State University College of Veterinary Medicine (2002-2005)

First Place Award in the Distinguished Graduate Publication Award, sponsored by Roche Applied Sciences, Department of Veterinary Biosciences, The Ohio State University (2003)

Second Place Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Structure & Function category), College of Veterinary Medicine, The Ohio State University (2004)

American Society for Microbiology/National Center for Infectious Disease post-doctoral fellowship to perform research in residence at the NCID, CDC, Atlanta, GA (2004)

Current Position:Research Scientist, AIDS Vaccine Development Laboratory (NY), International AIDS Vaccine Initiative

Thomas Carsillo PhD 2001-2006, MVIMGDissertation: A role for the major inducible 70 kDa heat shock protein

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(hsp72) in experimental measles encephalitis.Awards based upon graduate work:

First Place Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Immunology and Infectious Disease category), College of Veterinary Medicine, The Ohio State University (2003)

Second Place Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Immunology and Infectious Disease category), College of Veterinary Medicine, The Ohio State University (2004)

First Place Award in the Distinguished Graduate Publication Award, sponsored by Roche Applied Sciences, Department of Veterinary Biosciences, The Ohio State University (2004)

Second Place Award in the Distinguished Graduate Research Seminar Award, sponsored by Roche Applied Sciences, Department of Veterinary Biosciences, The Ohio State University (2005)

First Place Travel Award for poster presentation at the Advances in Veterinary Medicine Research colloquium (Immunology and Infectious Disease category), College of Veterinary Medicine, The Ohio State University (2005).

First Place Award in the Distinguished Graduate Research Seminar Award, sponsored by Roche Applied Sciences, Department of Veterinary Biosciences, The Ohio State University (2006)

Current Position:Research Scientist, Novartis

Matt Buccellato DVM, PhD2002-2008, VBSDissertation: Host mediated alteration of measles virus polymerase activity: consequences for the outcome of infection.Awards based upon graduate work:

Fellowship through the Barber Charitable Trust, The Ohio State University College of Veterinary Medicine (2003)

Fellowship through the NIH Institutional NRSA (Mouse Models of Human Disease, T32 RR07073) (2003-2004)

NIH K08 (NIAID) (2004-2008) 14th Annual Harold Casey Scholarship Award, the American

College of Veterinary Pathologists (2007)Current Position:

Staff Pathologists, Battelle Memorial Institute, Columbus, OH

Mi Young Kim DVM, PhD2008-2013, VBSDissertation: Hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the virus infected brain.Current Position:

Assistant Deputy Director, Pharmaceutical Safety Evaluation

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Division, Ministry of Food and Drug Safety, Korea

4) Doctoral Student Committee Member

Completed (n = 30):

Jan Andrews DVM, PhD 1996 defense, VBS (Michael Lairmore, advisor)Dissertation: The Modulation of HTLV-1 Gene Expression Following Induction of the Cellular Stress Response

Yilan Zhang MD, PhD 1997 defense, VBS (Yasuko Rikihisa, advisor)Dissertation: The Characterization of Ehrlichial Proteins and their Interaction with Macrophages

Nate Collins DVM, PhD 1999 defense, VBS (Michael Lairmore, advisor)Dissertation: Studies of pX Open Reading Frame I of Human T-Lymphotrophic Virus Type I using Infectious Molecular Clones

Jason Mott DVM, PhD (dual DVM/PhD program)2001 defense, VBS (Yasuko Rikihisa, advisor)Dissertation: Identification and Characterization of Survival Mechanisms of the Human Granulocytic Ehrlichiosis Agent and Identification and Characterization of an Ehrlichia risticii Strain Isolated from Aquatic Insects and Horse Isolates

Issa Toure, MS, PhD2002 defense, Department of Animal Science (David Latshaw, advisor)Dissertation: Influence of dietary calcium, cation-anion balance, genetics, and age on the development of leg bone development and leg bone abnormalities in broiler chicks.

Sadi Köksoy, MS, PhD2002 defense, VBS (Lawrence Mathes, advisor)Dissertation: Evaluation of functional aspects of CD8+/cytotoxic T cell responses in viral and allogeneic models.

Patrick Baker, PhD2003 defense, MCDB (Kate Eaton, advisor)Dissertation: Genetic regulation of virulence factors contributing to colonization and pathogenesis of Helicobacter pylori

Wayne Buck, DVM, PhD2004 defense, VBS (Lawrence Mathes, advisor)Dissertation: Neuropathogenic mechanisms of feline immunodeficiency virus infection

Bindhu Michael, DVM, PhD2004 defense, VBS (Michael Lairmore, advisor)Dissertation: Human T lymphotrophic virus type 1 (HTLV-1) accessory protein p30II modulates cellular and viral gene expression.

Li Xie PhD2005 defense, MCDB (Pat Green, advisor)Dissertation: Comparative studies on molecular mechanisms utilized

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by HTLV-1 and HTLV-2 in viral replication and induction of T cell transformation.

Hua Niu PhD2008 defense, VBS (Yasuko Rikihisa, advisor)Dissertation: Role of cellular autophagy and type IV secretion system in Anaplasma phagocytophilum infection.

Zhihui Cheng MS, PhD2008 defense, VBS (Yasuko Rikihisa advisor)Dissertation: Transcriptional regulator of Ehrlichia chaffeensis during intracellular development and the roles of OMPA in the bacterial infection and survival

Gwendolyn Lorch DVM, PhD2009 defense, VBS (Tom Rosol, advisor)Mechanisms of receptor-mediated hypercalcemia in human lung squamous cell carcinoma.

Mary Carsillo DVM, PhD2009 defense, VBS (Stefan Niewiesk, advisor)Mechanisms of measles virus-induced immune suppression in the cotton rat model.

Alex Hamberg, VMD, PhD 2009 defense, VBS (Steve Krakowka, advisor) Studies of circular single stranded DNA viruses of swine.

Ruthann Weimer, PhD2010 defense, IBGP (Mark Peeples, advisor)Respiratory syncytial virus based vectors for the treatment of cystic fibrosis.

Tzung-Huei Lai, PhD2010 defense, VBS (Yasuko Rikihisa, advisor)Two-component regulatory system of Anaplasma phagocytophilum and outer membrane protein P44 expression locus of Anaplasma platys.

Kathryn Gibson, DVM, PhD2011 defense, VBS (Yasuko Rikihisa, advisor)Neorickettsia spp.: Molecular classification of a vector and roles of bacterial surface proteins in pathogenesis.

Supranee Chaiwatpongsakorn, PhD2011 defense, VBS (Mark Peeples, advisor)Soluble respiratory syncytial virus fusion protein in the fully cleaved, pretriggered state, a tool to study protein triggering

Olga Malykhina, PhD2011 defense, IBGP (Mark Peeples, advisor)A respiratory syncytial virus replicon that is non-cytotoxic and capable of long-term foreign gene expression

Han Yin, PhD2011 defense, MCDB (Pat Green, advisor)Molecular analysis of HTLV-2 APH-2 in viral transformation, persistence and host immune response

Dhohyung Kim, PhD2012 defense, MCDB (Stefan Niewiesk, advisor)

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Mechanism of maternal antibody inhibition and vaccination strategies in the presence of maternal antibodies

Rami Doueiri, PhD2012 defense, MCDB (Pat Green, advisor)Characterization of the human T-cell leukemia virus type-2 p28 accessory protein

Jessica Grieves DVM, PhD2012 defense, Comparative and Veterinary Medicine (Joan Durbin, advisor)Respiratory syncytial virus: rodent models and vaccine development

Heather Costello, PhD2013 defense, IBGP (Mark Peeples, advisor)The N500 glycan of the respiratory syncytial virus F protein is required for fusion but not for stabilization or triggering of the protein.

Lyn Wancket DVM, PhD2013 defense, Comparative and Veterinary Medicine (Yusen Liu, advisor)Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease

Dipu Mohan Kumar PhD2013 defense, Comparative and Veterinary Medicine (Yasuko Rikihisa advisor)Insights into the host cell entry of Ehrlichia chaffeensis: role of the bacterial outer membrane protein EtpE

Melissa Hicks PhD2014 defense, Comparative and Veterinary Medicine (Jim DeWille advisor)Signaling networks as possible therapeutic implications in breast cancer

Feifei Wang2015 defense, Comparative and Veterinary Medicine (Li Wu advisor)Comparison of Mouse and Human SAMHD1’s role in retroviral restriction and cell cycle regulation

Gia Green2017 defense, MCDB (Stefan Niewiesk advisor)Respiratory syncytial virus pathogenesis and immune response in the cotton rat model

Current (n = 3): Tiffany Jenkins

2016-present (Mark Peeples advisor)Michael Martinez

2017-present (Pat Green advisor)Qi Yan

2017-present (Yasuko Rikihisa advisor)

5) External Examiner, Dissertation/Thesis Defense

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University of Veterinary Medicine Hannover (Germany)Hannover Graduate SchoolCenter for Systems Neuroscience (Zentrum für Systemische Neurowissenschaften, ZSN) Hannover

Nicole Jungwirth PhD dissertation (2016): Investigation of the modulatory effects of mesenchymal stem cells for support of remyelination in the CNS

University of British ColumbiaThe Faculty of Graduate and Postdoctoral StudiesPathology and Laboratory Medicine

Ye Que PhD dissertation (2017): Modulation and roles of stress-responsive proteins in coxsackievirus infection

B) Courses Taught (graded)

Teaching focus reflects both research expertise in molecular virology and viral pathogenesis, particularly neuropathogenesis of viral infection, as well as medical specialty training in comparative pathology, with focus on neuropathology. Graduate course work draws upon more specific areas of expertise such as the molecular biology of negative strand RNA viruses and comparative neuropathology. Courses that are part of the veterinary medical curriculum draw upon a more general knowledge base in virology, pathology, and histology (i.e., histology of nervous tissue).

B1) DVM Professional Degree Program

Past:

1990-2010 Applied Pathology, Veterinary Medicine 700.14Au Qtr. Credit Hours: 3

Enrollment: 13Percentage of Course Taught: 100

1995-2012 Microscopic and Developmental Anatomy, Veterinary Medicine 530Wi Qtr. Credit Hours: 5

Enrollment: 135 through 2011, subsequently 160Percentage of Course Taught: 12

1995-2012 Comparative Biology of Disease II, Veterinary Medicine 550.02Wi Qtr. Credit Hours: 5

Enrollment: 135 through 2011, subsequently 160Percentage of Course Taught: 17

1990-2012 Neurobiology, Veterinary Medicine 603Sp Qtr. Credit Hours: 8

Enrollment: 135 through 2011, subsequently 160Percentage of Course Taught: 19

1993-2011 Introduction to Applied Pathology, Veterinary Biosciences 720Sp Qtr. Credit Hours: 2 (P/G)

Enrollment: 12

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Percentage of Course Taught: 50 (team leader and founder of the course)

1995-2008 Applied Veterinary Medical Virology, Vet. Biosciences 715 Sp Qtr. Credit Hours: 2 (P/G)

Enrollment: 15Percentage of Course Taught: 5%

2011 Professional Development, Veterinary Medicine 614.01Au Qtr. Credit Hours: 1 (P)

Enrollment: 160Percentage of Course Taught: 5%

Discussion of research career opportunities (and how to get there)

Current:

2012-present Professional Development, Veterinary Medicine 6614.01Au Semester Credit Hours: 1 (P)

Enrollment: 160Contribution: 1 lecture (research careers)

2013-present Nervous System, Veterinary Medicine 6603Au Semester Credit Hours: 4 (P)

Enrollment: 160Contribution: 13 lectures, 2 laboratories (neuropathology)

B2) Graduate

Past:

1989-2011 Advanced Systemic Pathology I, Veterinary Biosciences 810Alternate yrs. Credit Hours: 4Au Qtr. Enrollment: 6-8

Percentage of Course Taught: 20 1997-98 Viral Pathogenesis and Oncogenesis, MMI/VBS 841

2004-2010 Credit Hours: 5Alternate years, Au Qtr. Enrollment: 10

Percentage of Course Taught: 12 1996-2011 Fundamentals of Virology, Medical Microbiology and Immunol. 754Alternate Years Credit Hours: 5Sp Qtr. Enrollment: 13 (2008)

Percentage of Course Taught: 14 2000 Virology Journal Club, Medical Microbiology and Immunology 814Wi Qtr. Credit Hours: 1

Enrollment: 5Percentage of course taught: 60

1993-2011 Molecular Virology of Animal and Plant Viruses Alternate Years Molecular Genetics 770

Sp Qtr. Credit Hours: 2Enrollment: 13 (15 in 2007)Percentage of Course Taught: 10

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2007, 2010 Advanced Veterinary Internal Medicine: NeurologyWi Qtr Veterinary Clinical Sciences 822.04

Credit Hours: 3Enrollment: 18 (2007)Percentage of Course Taught: 8

2012 Molecular Virology and Pathogenesis of VirusesAu Semester Veterinary Biosciences 7741

Credit Hours: 5Enrollment: 10Percentage of Course Taught: 7

2013 Advanced Internal Medicine, NeurologySp Semester Veterinary Clinical Sciences 8822.04

Credit Hours: 3Enrollment: 30Percentage of Course Taught: 3

Current:

2012-present Advanced Systemic Pathology I, Veterinary Biosciences 8812Alternate yrs. Credit Hours: 2Au Semester Enrollment: 6-8

Contribution: 8 lecture hours (neuropathology) & team lead

2012-present Veterinary Histopathology Seminar, VBS8895.04Credit Hours: 1Enrollment: 10-15Contribution: 1 seminar/year

B3) Undergraduate

Current:

2016-present Science, Engineering and Public PolicySp Semester John Glenn School of Public Affairs/Civil, Environmental and Geodetic

Engineering 5600 (ENVENG/PUBAFRS 5600)Credit Hours: 3Enrollment: 30Description: Presents a history of the interactions between science, engineering, and public policy in the United States and in the context of global concerns, how various federal government, universities, & corporations conduct & fund science and engineering, and how public sector interests & processes influence science, engineering & public policy.Contribution: 1 lecture hour (infectious diseases) (course coordinator – Jeff Bielicki)

C) Host for Visiting Scholar

Luciana Moro, DVM, PhD (Federal University of Minas Gerais, Brazil)

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1999-2000Stipend support was provided by a competitive scholarship from the CAPES Foundation (Coordinação de Aperfeiçoamento de Pessoal de Nivel Superior Ministério da Educação) of the Ministry of Education of Brazil. The project focused on mechanisms of paramyxovirus-induced apoptosis.

Paulo Ricardo Dell’Armelina Rocha, DVM (PhD student in Veterinary Sciences, University of Turin, Italy)

2011-2012Two projects were pursued. The first examined the potential therapeutic use of a genetically modified herpes simplex virus as an oncolytic agent, targeting gliomas in a mouse model. The second project focused on the role of a major inducible stress protein (heat shock protein 70, also known as hsp70) in mediating protection against VSV neurovirulence.

D) Senior honors thesis committee member

Ryan Jackwood2011 (Steve Krakowka, advisor)Characterization of Torque Teno virus by in vitro infection of gnotobiotic pigs: Torque Teno virus the cause of PAS?

E) Conference Sponsorship

Interdepartmental Neuropathology (“Brain Trim”) Conference, College of Veterinary Medicine, The Ohio State University (1991-2006, 2010-present)

Monthly conferences present outstanding clinical neurological cases submitted to the Department of Veterinary Biosciences for post mortem work-up. Cases are reviewed to address correlation between ante-mortem and post mortem findings, differential diagnoses, and the appropriateness of the diagnostic approach. Participants include faculty, residents, and graduate students from the Department of Veterinary Clinical Sciences and the Department of Veterinary Biosciences, as well as veterinary medical professional students (average of 15 participants per conference). This conference is one of four components of the course Seminars in Diagnostic Veterinary Pathology (VBS8895.02). The activity is part of the ACVIM Neurology RTP (Neuropathology Training Program) requirement, for which I am the Supervising Diplomate.

F) Advisor to Student Groups or Organizations

2003-04 The Ohio State University Student Chapter of the American College of Veterinary Pathologists

The purpose of the club is to create a forum in which to nurture interest in veterinary anatomic and clinical pathology as an area of expertise desirable in all clinical faculty as well as those whose career tracks include medical specialization in these disciplines.

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2005-2006 Inter-Professional Council, The Ohio State University

Identified students to represent the College of Veterinary Medicine in the 2nd Annual Case Competition, helped to identify topics for the competition, and served as a judge for the competition.

VI) SERVICE

A) Service as a Reviewer of Journals

Ad Hoc Reviewer:

Veterinary Pathology 1991-96, 2000-04, 2007-10, 2017

Toxicologic Pathology 1999Brain Research 2007

Neuropathology and Applied Neurobiology 2008 FASEB Journal 2009

Journal of Neuropathology & Experimental Neurology 2013Acta Neuropathologica Communications 2014

American Journal of Veterinary Research 1993, 2007 Journal of the American Veterinary Medical Association 1998 The Canadian Veterinary Journal 2009 Veterinary Clinical Pathology 2009

BVM Veterinary Research 2018

Proceedings of the National Academy of Sciences (USA) 2003, 2007Journal of Biological Chemistry 2006, 2007Biochemistry 2008

Veterinary Immunology and Immunopathology 1994-96, 1998Veterinary Microbiology 1998-99, 2014Comparative Immunology, Microbiology and Infectious Diseases 2011Clinical and Vaccine Immunology 2006-07Clinical and Experimental Immunology 2008FEMS Immunology and Medical Microbiology 2007Trends in Microbiology 2003Molecular and Cellular Probes 1993Journal of Molecular Imaging and Dynamics 2012Molecular Cancer Research 2017

Journal of Virology 1997, 1999, 2002-2014, 2016-2017

Virology 2005Journal of General Virology 2005, 2009, 2012,

2014Journal of Infectious Diseases 2012Virus Research 2006

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Viruses 2014Journal of Neurovirology 1997Retrovirology 2009Virology Journal 2009AIDS Research and Human Retroviruses 2011-12PLoS One 2013, 2017BMC Microbiology 2014

B) Service as Consultant to Government Agencies

Grant Review Panel Member

Animal Virology Panel, Mechanisms of Disease Section, National Research Initiative Competitive Grants Program, Cooperative State Research Service, United States Department of Agriculture (1992)

Virology Panel, Molecular and Cellular Basis of Animal Disease Section, National Research Initiative Competitive Grants Program, Cooperative State Research Service, United States Department of Agriculture (1993, 2000)

Experimental Virology/Virology B Study Section, Infectious Diseases andMicrobiology Integrated Review Group, Center for Scientific Review, NationalInstitutes of Health (2003-2005).

Prokaryotic and Eukaryotic Molecular Biology and Genetics (ZRG1 F08)Fellowship study section, National Institutes of Health (2001)

Special Emphasis Panel (ZRG1 F13-C) Fellowship study section, NationalInstitutes of Health, July 17-18 (2008)

F13 Infectious Diseases and Microbiology Fellowship Review Panel, National Institutes of Health, March 24-25 (2010)

Special Emphasis Panel, NIH/NIEHS, Pathology Peer Review and Pathology Support for the Divisions of the National Toxicology Program (DNTP) and the Division of Intramural Research (DIR) at the National Institute of Environmental Health Sciences (Pathology Contract Review ES2014009) (2015)

Temporary Member, Grant Review Panel

Canine Health Foundation, American Kennel Club (1999)

Virology Panel, Molecular and Cellular Basis of Animal Disease Section,National Research Initiative Competitive Grants Program, Cooperative StateResearch Service, United States Department of Agriculture (1994, 1998,2001)

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AIDS and Related Research Study Section (Vaccine), Center for ScientificReview, National Institutes of Health (2001)Experimental Virology Study Section, Infectious Diseases and MicrobiologyIntegrated Review Group, Center for Scientific Review, National Institutes ofHealth (2000-2003).

Virology B Study Section, Infectious Diseases and Microbiology IntegratedReview Group, Center for Scientific Review, National Institutes of Health(2006).

Biotechnology and Biological Sciences Research Council, United Kingdom(2006, 2013).

Clinical Neuroimmunology and Brain Tumors Study Section, Brain Disorders and Clinical Neuroscience Integrated Review Group, Center for Scientific Review, National Institutes of Health (2016).

Microbiology and Infectious Diseases Research Committee, Microbiology, Infectious Diseases and AIDS Initial Review Group, National Institute of Allergy and Infectious Disease (2018).

C) Service to Professional Societies

Chairperson

Neuropathology Specialty Group, 46th Annual Meeting of the American College of Veterinary Pathologists, Atlanta, GA (1995)

Concurrent Session II, 58th Annual Meeting of the American College of Veterinary Pathologists, November 10-14, Savannah, GA (2007)Session title: Heat Shock Proteins in Immunity and Disease

ACVP-ASIP Symposium (Inside Out: Extracellular Roles of Heat Shock Proteins), Experimental Biology annual meeting, April 20-24,Boston MA (2013)

Co-Chairperson

Neuropathology Specialty Group, 45th Annual Meeting of the American College of Veterinary Pathologists, Montreal, Quebec, Canada (1994)

ACVP-ASIP Symposium (Evolutionary Aspects of Animal Models), Experimental Biology annual meeting, San Diego CA (2012).

Committee Member

Education Committee, American College of Veterinary Pathologists (2005)

Scientific Symposium Committee (TASS) of the American College of

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Veterinary Pathologists (ACVP) – renamed the Intersociety Experimental Pathology Committee (IEPC) (2006-present)

The ACVP has developed a partnership with the American Society of Investigative Pathology through the IEPC with the goal of identifying common goals and roles for pathology in biomedical investigations.

Emerging Issues Committee, Ohio Veterinary Medical Association (2011-2012)

Strategic Planning Task Force, American College of Veterinary Pathologists (2016-2018)

Panelist

Forum presentation entitled “Residency Training – Who Succeeds,What Fails, What Works?”, Education Specialty Group, 57th Annual Meeting of the American College of Veterinary Pathologists, Tucson, Arizona (2006)

The panel included M. Christopher (UCDAVIS), D. Denicola (IDEXX), M. Oglesbee (OSU), and Rose Raskin (Purdue)

Neuropathology Mystery Slide Seminar, annual meeting of the American College of Veterinary Pathologists

2009, 2012

Grant Reviewer

Craig H. Neilson Foundation (2009)The foundation funds research in spinal cord injury.

D) Clinical Service

1989-2009 Necropsy Rotation (1 month/year), Department of Veterinary Biosciences, The Ohio State University

1989-2009 Surgical Biopsy Rotation (2 months/year), Department of Veterinary Biosciences, The Ohio State University

E) Other Service

National

External Review Committee Member, Department of Pathobiology PhD Program Review, Texas A&M University (2009)

Members: Drs. Anthony Confer (Chair, Oklahoma State University), Edward Hoover (Colorado State University), and Michael Oglesbee.

Invited Presentation, annual meeting of the American Association of Veterinary Medical Colleges (“The Need for Veterinarians in Biomedical Research”), Washington D.C. (2010)

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Promotion and tenure external review University of South Florida, College of Medicine (2011) University of North Carolina Charlotte, Department of Biology (2011) Purdue University, Department of Basic Medical Sciences, College of

Veterinary Medicine (2012) Iowa State University, College of Veterinary Medicine (2012) University of Michigan, School of Public Health (2013) University of Georgia, Department of Pathology, College of Veterinary

Medicine (2013) The University of Texas MD Anderson Cancer Center (2013) University of Missouri, Department of Biomedical Sciences, College of

Veterinary Medicine (2014) University of Minnesota, Department of Veterinary Population Medicine,

College of Veterinary Medicine (2014, 2015) Columbia University, Department of Pediatrics (2016) Virginia Tech, Department of Biomedical Sciences and Pathobiology,

Virginia-Maryland Regional College of Veterinary Medicine (2016) University of Iowa, Department of Pathology, Carver College of Medicine

(2016) Rutgers University, New Jersey Medical School and Robert Wood Johnson

Medical School (2016) Vanderbilt University Medical Center, Department of Pathology, Microbiology

and Immunology (2017)

Consultant for the Provost, University of Illinois, regarding potential reorganization of graduate programs within the College of Veterinary Medicine (2012)

Committee Members (Univ. Ill.): May Berenbaum (Chair, Dept. Entomology), Michael Plewa (Dept. Crop Sciences), and Jodi Flaws (Dept. Vet. Biosciences).External Committee Members: Vilma Yuzbasiyan-Gurkan (Michigan State Univ.) and Michael Oglesbee

Conference Organizer, Merial-NIH National Veterinary Scholars Symposium, Columbus, Ohio, July 18-31, 2016

External Advisory Board, Johns Hopkins Summer Research Program for Veterinary Medical Students (2017-present)

State

Accreditation review, Ohio Animal Diagnostic Laboratory (2010, 2015)OSU CVM representation (one of four) for the diagnostic laboratory in their meeting with the American Association of Veterinary Laboratory Diagnosticians accreditation team

Emerging Issues committee member, Ohio Veterinary Medical Association (2011-12)

University

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Scientific Review

Member, Institutional Biosafety Committee (Recombinant DNA) (1995-2003)

Ad Hoc Reviewer, Roessler Scholarship applications, College of Medicine(2006)

Review Committee Member, OSU Center for Clinical and Translational Science (CCTS) Career Development Program (Davis Bremer Pre-K Application and KL2 Mentored Career Development Grant) (2009, 2017)

Administration

Fellow, Academic Leadership Program, Committee on Institutional Cooperation (2010-11)

Member, Public Health Preparedness in Infectious Disease (PHPID) Steering Committee (2010-2016)

The Public Health Preparedness for Infectious Diseases (PHPID) initiative is a collaboration of six colleges with a mission of protecting the public from infections. More than 125 faculty across these colleges contribute to this initiative. PHPID faculty translate scientific discoveries into clinical applications, detect the presence of emerging infectious diseases within communities, prevent human infection from zoonotic organisms, address food safety issues, and train professionals to protect the public. The purpose of the organization is to foster cross-disciplinary research, to support faculty hires that facilitate cross-disciplinary research, and provide funding for exploratory research projects.

Faculty Director, Discovery Theme in Infectious Disease, The Ohio State University (2014-present)

This is a collaborative effort involving 10 colleges at the University and the University Office of Research, Industry Liaison Office and the Office of Academic affairs. The mission is to control the spread and severity of infectious diseases through the creation and dissemination of knowledge, practices and products, and this will be achieved by building multidisciplinary active networks in four high impact programmatic areas.

Director, Infectious Diseases Institute, The Ohio State University

Advocate (2016-2018) for Gender Equity at The Ohio State UniversityPart of the NSF Advance Program in collaboration with the North Dakota State University, with local support from the Women’s Advisory Committee. The mission is to help men become more effective allies in diversity efforts, specifically as relates to gender equity.

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Member, Oversight Committee, Global Water Institute, The Ohio State University (2016-present)

Member, Internal Advisory Board, “Cure CF Columbus” Research and Development Program (a collaborative effort between the Nationwide Children’s Hospital and Research Institute and The Ohio State University) (2017 – present)

Search Committees

Chair for the Department of Microbial Infection and Immunity, College of Medicine (2018-2018)

College

Scientific Review

Member, Council for Research (1995-96, 1999-2001)

Poster Judge, Advances in Veterinary Medicine Scientific Session (2003-present)

External Reviewer, Grant Writer’s workshop, OARDC, College of Food, Agricultural, and Environmental Sciences (2004)

Administration

Chair, Veterinary Clinical Sciences Departmental Chair Review Committee(2005)

Representative of the Ohio State University to the CIC Veterinary Consortium(2005)

Purpose: organizational meeting to develop a plan for creating research experiences for veterinary medical students enrolled in each of the Big Ten programs.

Chair, Promotion and Tenure Committee (2007-2010)Committee member 2003-10

Chair, Council for Graduate Studies (2009-10)

Director, Summer Research Program, College of Veterinary Medicine, The Ohio State University (2010-present)

The program provides intensive research experiences for veterinary medical students interested in research. Individuals are selected each year based upon a research proposal developed by the student in collaboration with their intended faculty mentor. Students perform the bulk of the research during the summer, present research findings at

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both local (e.g., College of Veterinary Medicine Research Day) and national meetings (e.g., the Merial-NIH Veterinary Scholars Symposium, or a scientific meeting within their field of study). Faculty mentors derived from multiple colleges at The Ohio State University, including Veterinary Medicine, Medicine, Pharmacy and Optometry. Funding is provided from NIH, Merial, department and college monies, and development funds. Dr. Oglesbee is director of the NIH T53 (Short Term Research Training for Veterinary Students) supporting this program, now in its 10th year. The T35 supports 10 students per year, and total program size averages 25 students per year.

Department Chair (Interim), Veterinary Biosciences(2010-2011)

Department Chair, Veterinary Biosciences(2011-2017; 12/01/2011 – 01/30/2017)

Research: The CY16 was the most successful for CVM investigators in the past 10 years based upon expenditures (with the exception of the 2008 NIH American Recovery and Reinvestment Funds) and the highest F&A recovery. Nine of the top 10 CVM research programs were VBS faculty, based upon extramural grant expenditures and indirect cost recovery. Total VBS expenditures for CY16 were $6.8M, a 24% increase over CY15, representing an F&A recovery rate of 50.4%. The increase was fueled by new research-intensive hires in addition to grant application success rates of existing faculty.

The following research-intensive tenure track faculty were hired:Jianrong Li (2013 - )Estelle Cormet-Boyaka (2016 - )

Dr. Cormet-Boyaka was initially hired as a research track Assistant Professor in 2013.

Sanggu Kim (2016 - )Shan-Lu Liu (2016 - )Lara Sucheston-Campbell (2016 - )Namal Liyanage (2017 - )

Teaching and Service: Diagnostic services (applied pathology, clinical pathology, parasitology, and microbiology) were combined into a single entity, the Clinical Diagnostic Laboratories, using a common information system. The applied pathology and clinical pathology services were restructured so that they are now driven by teaching service intensive faculty, taking advantage of turnover created by faculty retirements. The result was a dramatic improvement in stakeholder satisfaction. As stated in a 2016 stakeholder survey: “I personally think this is the best service/attitude/helpfulness and interaction with VCS that I have experienced in my 40 years at OSU”. Ninety percent of those surveyed were satisfied with the service. The following hires were key to these changes:

Rachel Cianciolo (2015 - )

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Ryan Jennings (2016 - )Jessica Hokamp (2017 - )

The Comparative Pathology and Mouse Phenotyping Shared Resource of the NCI-designated Comprehensive Cancer Center is based in the department. A second pathologist was hired to support the service in response to rising demand, contributing to an NCI site visit/evaluation in that ranked the shared resource as outstanding. The following hires were made to maintain two faulty in the CPMPSR:

Brad Bolon (2011-2014)Sue Knoblaugh (2015 - )

Admissions & Search Committees

Interviewer for the Admissions Committee (2006-present)

Search Committees: Neurology Faculty (Dept. Veterinary Clinical Sciences) (2006-2008)

Dr. Ronaldo de Costa and Sarah Moore were hired as a result of this search.

Dean, College of Veterinary Medicine (2008-09) Chair, Department of Veterinary Clinical Sciences (2014-15)

(Committee Chair) Clinical Microbiology Faculty, Department of Veterinary Clinical

Sciences (2017)

Faculty Mentoring Committees (outside of VBS)

Ronaldo DaCosta, tenure track faculty (neurology) in the Department ofVeterinary Clinical Sciences (2008-2012)

Fred DeGraves, tenure track faculty, Department of Veterinary PreventativeMedicine (2007-10)

Sarah Moore, tenure track faculty (neurology) in the Department of Veterinary Clinical Sciences (2010-2015)

Department

Administration

2002-2010 Chair, Graduate Studies Committee In 2008, the VBS graduate program was named one of 12 programs at The Ohio State University that stand out in terms of quality, planning, focus, and the potential to enhance the standing of the university, this based upon a Doctoral Program Assessment led by Pat Osmer, vice provost for graduate studies and dean of the Graduate School. A total of 91 programs were evaluated.

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2005 Research and Clinical Track Faculty CommitteePurpose: Evaluate issues and benefits for research and clinical track faculty positions within our department.

2007 Core Committee to prepare the Departmental Program Review for the Office of Academic Affairs

2012-present Director, Gnotobiotic Life Shared ResourceThe resource includes dedicated technical staff and equipment that support the derivation and maintenance of animals in a germ free environment for experiments primarily focused upon microbial pathogenesis, immunology, and the influence of microbiomes. Pigs and mice and the predominant species used, although capacity and expertise exists for the derivation and maintenance of germ free dogs.

Faculty Search Committees

2001 Department ChairDr. Michael Lairmore was appointed chair as a result of this search.

2002 Position in comparative medical genetics2005 Position in pathology/toxicology/physiology

Dr. Ian Davis was hired as a result of this search.2006-09 Positions in anatomic pathology (Search Committee Chair)

Three hires were the result of this search: Dr. Chris Premanandan, teaching/service intensive

(Clinical Track) Dr. Tracey Papenfuss, research intensive (Tenure Track) Dr. Krista La Perle, teaching service intensive (Clinical

Track) and head of the Mouse Phenotyping Core Facility

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