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LTP. Read pages 575 - 592. LTP. A persistent strengthening of synapses based on recent patterns of activity. review. Graded potential Action potential EPSP. Schaffer collaterals of CA3 pyramidals onto CA1 pyramidal. - PowerPoint PPT Presentation
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LTP
Read pages 575 - 592
LTP
• A persistent strengthening of synapses based on recent patterns of activity.
review
• Graded potential
• Action potential
• EPSP
Schaffer collaterals of CA3 pyramidals onto CA1 pyramidal.
• If high frequency train of stimuli (AP) get LTP, evident as a long-lasting increase in EPSP amplitude.
• LTP occurs in many other regions of the brain: cortex, amygdala, cerebellum
LTP is state-dependent
• LTP occurs when the post synpatic response is quick and large.
• E.g. application of post synaptic current
• The state of the membrane potential of the post synaptic cell.
• Strong temporal linkage of pre and post synaptic events
LTP input specificity
• Only activated synapses are affected
• Applies to memory.
LTP is associative
• In one pathway is weakly activated during stimulation, then that synapse will be strengthened as well.
• Selective enhancement
• Cellular analogue of associative learning, but expected of all neural networks
LTP
• State dependent - the NMDA receptor needs depolarization to remove Mg inhibition
• Input specific -NMDA channels open only at stimulated synapses
• Associative - the depolarization at the neighboring synapse can affect an non potentiated synapse.