A NEW METHOD FOR TARGETING ENVELOPED VIRUSES

LJ-001

Skeleton Enveloped and Naked Viruses

Modes of Infection

LJ-001

Naked Viruses

Gary E. Kaiser

What are enveloped viruses?

Skeleton Enveloped and Naked Viruses

Modes of Infection

LJ-001

Russell Kightley Media

Excretory Pathways Naked

Lytic cycle Exocytosis

Enveloped

Dan StowellBotany Online Visual Resource Library

Skeleton Enveloped and Naked Viruses

Modes of Infection

LJ-001

LJ001 an aryl methyldiene rhodanine derivative

A small anti-viral molecule effective against enveloped (but not naked) viruses.

Wolf et. al.

LJ001 acts on virus membranes in an irreversible manner

Wolf et. al.

Broad Spectrum Influenza A Filoviruses Poxviruses Arenaviruses Bunyaviruses Paramyxoviruses Flaviviruses HIV-1 Hepatitis C Ebola And others

Viruses lack a ‘biogenic’ membrane

Viruses can’t make their own proteins or repair their membrane like a cell can

How?

Russell Kightley Media

Wolf et. al.

How we would use this Still very early in development, further

testing needed

Shorten Viral Infection Course Preventative Measure?

Could be put in condoms

New treatment for multiple viruses Eliminate temporary infections Fight Chronic ones

LJ001 is effective at very low doses Potentially Excellent Therapeutic Index

Sources (pictures not from papers)

Russell Kightley Media Virco Online Humanitarian Futures Programme Gary E. Kaiser HOPES (The Huntinton’s Disease

Outreach Project for Education) at Stanford

Molecular Station

Sources(papers)

Wolf et. al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. Epub 2010 Jan 28.

Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol. 2007 Aug;5(8):583-97.

Kudchodkar S., Levine, B. Viruses and Autophagy. Reviews in Medical Virology. 2009; 19: 359-378

Melikyan GB. Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm. Retrovirology. 2008 Dec 10;5:111.

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