List of Publications, Lectures, and Contributions to ...List of Publications, Lectures, and Contributions to Conferences, Prof. Dr. Eva Freisinger (* denotes the corresponding author)

E. Freisinger List of Publications Page 1/12

List of Publications, Lectures, and Contributions to Conferences,

Prof. Dr. Eva Freisinger

(* denotes the corresponding author)

Selected Publications _______________________________________________________________________________________________________________

(78) X. Wan, E. Freisinger*

"Incorporation of sulfide ions into the cadmium(II)-thiolate cluster of Cicer arietinum metallothionein2"

Inorg. Chem. 2013, 52, 785-792 (doi: 10.1021/ic301907j).

(72) J. Loebus, E. A. Peroza, N. Blüthgen, T. Fox, W. Meyer-Klaucke, O. Zerbe*, E. Freisinger*

"Protein and metal cluster structure of the wheat metallothionein domain -Ec-1: the second part of the

puzzle"

J. Biol. Inorg. Chem. 2011, 16, 683-694 (doi: 10.1007/s00775-011-0770-2).

(68) E. A. Peroza, R. Schmucki, P. Güntert, E. Freisinger*, O. Zerbe*

"The E-domain of wheat Ec-1 metallothionein: A metal-binding domain with a distinctive structure"

J. Mol. Biol. 2009, 387, 207218 (doi: 10.1016/j.jmb.2009.01.035).

(64) E. Freisinger*

Review Article and Journal Cover

"Plant MTs - long neglected members of the metallothionein superfamily"

Dalton Trans. 2008, 66636675 (doi: 10.1039/b809789e).

Article also featured in: Chemical Biology 2009, 4, B4.

(58) E. Freisinger, R. K. O. Sigel*

"From nucleotides to ribozymes A comparison of their metal ions binding properties"

Coord. Chem. Rev. 2007, 251, 18341851 (doi: 10.1016/j.ccr.2007.03.008).

(51) E. Freisinger, A. P. Grollman, H. Miller*, C. Kisker*

"Lesion (in)tolerance reveals insights into DNA replication fidelity"

EMBO J. 2004, 23, 14941505 (doi: 10.1038/sj.emboj.7600158).

PhD thesis _______________________________________________________________________________________________________________

E. Freisinger

"Structurelle Untersuchungen zur Koordination von Metallionen an Modellnukleobasen"

Logos Verlag, Berlin, Germany, 2000, 377 pp.

ISBN: 3-89722-416-X


Full list of publications

2013 _______________________________________________________________________________________________________________

(85) S. Phongtongpasuk, S. Paulus, J. Schnabl, R. K. O. Sigel*, B. Spingler*, M. J. Hannon*, E. Freisinger*

"Binding of a designed anti-cancer drug to the heart of an RNA three-way junction"

Angew. Chem. Int. Ed. 2013, available online (doi: 10.1002/anie.201305079 and

10.1002/ange.201305079).

(84) E. A. Peroza, A. C. S. Cabral, X. Wan, E. Freisinger*

"Metal ion release from metallothioneins: Proteolysis as an alternative to oxidation"

Metallomics 2013, 5, 1204-1214 (doi: 10.1039/C3MT00079F) – Open Access.

(83) J. Loebus, B. Leitenmaier, D. Meissner, B. Braha, G.-J. Krauss, D. Dobritzsch*, E. Freisinger*

"The major function of a metallothionein from the aquatic fungus Heliscus lugdunensis is cadmium

detoxification"

J. Inorg. Biochem. 2013, 127, 253-260 (doi: 10.1016/j.jinorgbio.2013.06.001).

(82) T. Huber, E. Freisinger*

"Sulfide ions as modulators of metal-thiolate cluster size in a plant metallothionein"

Dalton Trans. 2013, 42, 8878-8889 (doi: 10.1039/C3DT32438A) – Open Access.

(81) X. Wan, O. Schicht, E. Freisinger*

"Cu(I) coordination by two plant metallothioneins"

Z. Anorg. Allg. Chem. 2013, 639, 1365-1369 (doi: 10.1002/zaac.201300096).

(80) C. Radunsky, D. Megger, A. Hepp, J. Köster, E. Freisinger, J. Müller*

"A family of hydrazone-based nucleosides for use in metal-mediated base pairs"


(79) E. Freisinger*, M. Vašák*

Invited Review: Cadmium: From Toxicity to Essentiality

"Cadmium in metallothioneins"

Met. Ions Life Sci. 2013, 11, 339-371 (doi: 10.1007/978-94-007-5179-8_11).


"Incorporation of sulfide ions into the cadmium(II)-thiolate cluster of Cicer arietinum metallothionein2"

Inorg. Chem. 2013, 52, 785-792 (doi: 10.1021/ic301907j).

2012 _______________________________________________________________________________________________________________

(77) D. Donghi, S. Johannsen, R. K. O. Sigel*, E. Freisinger*

"NMR spectroscopy in bioinorganic chemistry"

Chimia 2012, 66, 791-797 (doi: 10.2533/Chimia.2012.791).


(76) K. Seubert, D. Böhme, J. Kösters, W.-Z. Shen, E. Freisinger, J. Müller*

"N-Methyl-2,2’-dipicolylamine domplexes as potential models for metal-mediated base pairs"


2011 _______________________________________________________________________________________________________________

(75) A. Galstyan, W.-Z. Shen, E. Freisinger, H. Alkam, W. Hiller, P. J. Sanz Miguel, M. Schürmann, B.

Lippert*

"Supramolecular isomerism of 2,2'-bipyrazine complexes with cis-(NH3)2PtII: Ligand rotational state and

sequential orientation determine the 3D shape of metallacycles"

Chem. Eur. J. 2011, 17, 1077110780 (doi: 10.1002/chem.201101381).

(74) E. Freisinger*

Invited Review for Special Issue: Metallothioneins

"Structural features specific to plant metallothioneins"

J. Biol. Inorg. Chem. 2011, 16, 1035-1045 (doi: 10.1007/s00775-011-0801-z).

(73) A. Galstyan, P. J. Sanz Miguel, J. Wolf, E. Freisinger, B. Lippert*

"Discrete molecular squares {[(en)M(CN)]4}4+ derived from [(en)M(CN)2] (with M = PtII, PdII)"

Eur. J. Inorg. Chem. 2011, 1649-1656 (doi: 10.1002/ejic.201001216).

(72) J. Loebus, E. A. Peroza, N. Blüthgen, T. Fox, W. Meyer-Klaucke, O. Zerbe*, E. Freisinger*

"Protein and metal cluster structure of the wheat metallothionein domain -Ec-1: the second part of the

puzzle"

J. Biol. Inorg. Chem. 2011, 16, 683-694 (doi: 10.1007/s00775-011-0770-2).

2010 _______________________________________________________________________________________________________________

(71) E. Freisinger*

"The metal-thiolate clusters of plant metallothioneins"

Chimia 2010, 64, 217-224 (doi: 10.2533/chimia.2010.1).

2009 _______________________________________________________________________________________________________________

(70) S. Muhammad*, G. Murtaza, E. Freisinger, M. K. Rauf, A. Saeed

"(Z)-2-Phenyl-3-pivaloyl-1,1-dipropylguanidine"

Acta Cryst. 2009, E65, o2073o2074 (doi: 10.1107/S160053680902978X).


"The plant metallothionein 2 from Cicer arietinum forms a single metal-thiolate cluster"

Metallomics 2009, 1, 489-500 (doi: 10.1039/B906428a).


(68) E. A. Peroza, R. Schmucki, P. Güntert, E. Freisinger*, O. Zerbe*

"The E-domain of wheat Ec-1 metallothionein: A metal-binding domain with a distinctive structure"

J. Mol. Biol. 2009, 387, 207218 (doi: 10.1016/j.jmb.2009.01.035).

(67) E. Freisinger*

Invited Review and Book Cover: Metallothioneins and Related Chelators

"Metallothioneins in plants"

Met. Ions Life Sci. 2009, 5, 107153 (doi: 10.1039/9781847558992-00107).

(66) E. A. Peroza, A. Al Kaabi, W. Meyer-Klaucke, G. Wellenreuther, E. Freisinger*

"The two distinctive metal ion binding domains of the wheat metallothionein Ec-1"

J. Inorg. Biochem. 2009, 103, 342353 (doi:10.1016/j.jinorgbio.2008.11.008).

(65) O. Schicht, E. Freisinger*

Invited Publication: Protagonists in Chemistry – Bernhard Lippert

"Spectroscopic characterization of Cicer arietinum metallothionein 1"

Inorg. Chim. Acta 2009, 362, 714724 (doi:10.1016/j.ica.2008.03.097).

2008 _______________________________________________________________________________________________________________

(64) E. Freisinger*

Review Article and Journal Cover

"Plant MTs - long neglected members of the metallothionein superfamily"


Article also featured in: Chem. Biol. 2009, 4, B4.

(63) E. Freisinger*, R. Griesser, B. Lippert, C. F. Moreno-Luque, J. Niclós-Gutiérrez, J. Ochocki, B. P.

Operschall, H. Sigel*

"Comparison of the surprising metal ion-binding properties of 5- and 6-uracilmethylphosphonate

(5Umpa2– and 6Umpa2–) in aqueous solution and crystal structures of the dimethyl and di(iso-propyl) esters

of H2(6Umpa)"


(62) W.-Z. Shen, R.-D. Schnebeck, E. Freisinger, B. Lippert*

"On the interrelationship of µ-OH bridged dimers, trimers, and tetramers of (en)PtII and their Ag+ adducts"


(61) E. A. Peroza, E. Freisinger*

"Tris is a non-innocent buffer during intein-mediated protein cleavage"

Protein Expres. Purif. 2008, 57, 217225 (doi:10.1016/j.pep.2007.10.003).

(60) J. Müller*, F.-A. Polonius, E. Freisinger, E. G. Bardajía

"X-ray crystallographic study of several 2´-deoxy--D-ribonucleosides with 1-deazapurine-derived

aglycones"

Carbohyd. Res. 2008, 343, 397403 (doi:10.1016/j.carres.2007.11.007).


2007 _______________________________________________________________________________________________________________

(59) E. Gil Bardaji, E. Freisinger*, B. Costisella, C. A. Schalley, W. Brüning, M. Sabat, B. Lippert*

"Mixed-metal (platinum, palladium), mixed-pyrimidine (uracil, cytosine) self-assembling

metallacalix[n]arenes: Dynamic combinatorial chemistry with nucleobases and metal species"


(58) E. Freisinger, R. K. O. Sigel*

"From nucleotides to ribozymes A comparison of their metal ions binding properties"

Coord. Chem. Rev. 2007, 251, 18341851 (doi: 10.1016/j.ccr.2007.03.008).

(57) E. A. Peroza, E. Freisinger*

"Metal ion binding properties of Triticum aestivum Ec-1 metallothionein: Evidence supporting two

separate metal-thiolate clusters"

J. Biol. Inorg. Chem. 2007, 12, 377391 (doi: 10.1007/s00775-006-0195-5).

(56) E. Freisinger*

Invited Publication: Inorganic Chemistry The Next Generation

"Spectroscopic characterization of a fruit-specific metallothionein: M. acuminata MT3"

Inorg. Chim. Acta 2007, 360, 369380 (doi: 10.1016/j.ica.2006.07.059).

(55) S. Gallo, E. Freisinger, R. K. O. Sigel*


"Towards the synthesis of light stable coenzyme B12 analogs"


(54) J. Müller*, E. Freisinger, P. Lax, D. A. Megger, F. Polonius


"Interaction of Pt(II) and Pd(II) complexes of terpyridine with 1-methylazoles: A combined experimental

and density functional study"


2006 _______________________________________________________________________________________________________________

(53) M. Willermann, C. Mulcahy, R. K. O. Sigel, M. Morell Cerdà, E. Freisinger, P.J. Sanz Miguel, M.

Roitzsch , B. Lippert*

"Pyrazine as a building block for molecular architechtures with PtII"

Inorg Chem. 2006, 45, 20932099 (doi: 10.1021/ic051966k).

2005 _______________________________________________________________________________________________________________


(52) J. Müller*, E. Freisinger

"[(1-Methylcytosine)2H]I, an asymmetric base pair"

Acta Cryst. 2005, E61, o320o322 (doi: 10.1107/S1600536805000693).

2004 _______________________________________________________________________________________________________________

(51) E. Freisinger, A. P. Grollman, H. Miller*, C. Kisker*


EMBO J. 2004, 23, 14941505 (doi: 10.1038/sj.emboj.7600158).

2003 _______________________________________________________________________________________________________________

(50) E. Freisinger, I. B. Rother, M. S. Lüth, B. Lippert*

"Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII:

Artificial nucleobase quartets and CH…N bonds"

Proc. Natl. Acad. Sci. USA 2003, 100, 37483753 (doi: 10.1073/pnas.0436700100).

(49) E. Freisinger, A. Fernandes, A. P. Grollman, C. Kisker*

"Crystallographic characterization of an exocyclic DNA adduct: 3,N4-etheno-2'-deoxycytidine in the

dodecamer 5'-CGCGCGCG-3' "

J. Mol. Biol. 2003, 329, 685697 (doi:10.1016/S0022-2836(03)00445-5).

(48) B. Beck, A. Schneider, E. Freisinger, D. Holthenrich, A. Erxleben, A. Albinati, E. Zangrando, L.

Randaccio, B. Lippert*

"Inter- and intra-molecular condensation patterns of (en)PdII with trans-[a2PtL2]2+ (a = am(m)ine, L = 2-

aminopyridine): PtPd3 and Pt2Pd4 species with multiple amide bridges. Unexpected trapping of a pair of

nitrate ions by a Pt2Pd4 double cone"

Dalton Trans. 2003, 25332539 (doi: 10.1039/B301708G).

(47) J. Müller*, E. Freisinger, P. J. Sanz Miguel & B. Lippert*

"Diplatinum(III) complexes with four bridging 1-methylcytosinato nucleobases derived from a

mononuclear trans-(NH3)2PtII complex and CuII "

Inorg. Chem. 2003, 42, 51175125 (doi: 10.1021/ic0343152).

2002 _______________________________________________________________________________________________________________

(46) W. Brüning, I. Ascaso, E. Freisinger, M. Sabat, B. Lippert*

Invited Publication: Protagonists in Chemistry – Helmut Sigel

"Metal-stabilized rare tautomers of nucleobases. 8. Promotion of rare cytosine tautomer upon complex

formation with (dien)M2+ (M = Pt, Pd)"

Inorg. Chim. Acta 2002, 339, 400410 (doi: 10.1016/S0020-1693(02)00938-6).


(45) R. K. O. Sigel*, E. Freisinger, M. Abbate, B. Lippert*


"Hydrogen bonding patterns of 7,9-dimethylguanine and its trans-platinum(II) complexes"


(43) X. Riera, V. Moreno*, E. Freisinger, B. Lippert


"Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reaction with 9-ethylguanine and study of their

antiproliferative activity"

Inorg. Chim. Acta 2002, 339, 253264 (doi: 10.1016/S0020-1693(02)00957-X).

(44) W. Brüning, E. Freisinger, M. Sabat, R. K. O. Sigel, B. Lippert*

"N1 and N3 linkage isomers of neutral and deprotonated cytosine with trans-(CH3NH2)2PtII"

Chem. Eur. J. 2002, 8, 46814692 (doi: 10.1002/1521-3765(20021018)8:20<4681::AID-

CHEM4681>3.0.CO;2-P).

(42) G. B. Onoa, V. Moreno*, E. Freisinger, B. Lippert

"Pd(II)- and Pt(II)-cimetidine complexes. Crystal structure of trans-[Pt(N,S-cimetidine)2]Cl2*12H2O"

J. Inorg. Biochem. 2002, 89, 237247 (doi: 10.1016/S0162-0134(01)00416-0).

(41) G. Kampf, M. Willermann, E. Freisinger, B. Lippert*

"Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including

guanine nucleobases"


2001 _______________________________________________________________________________________________________________

(40) C. F. Moreno-Luque, E. Freisinger, R. Griesser, J. Ochocki, B. Lippert*, H. Sigel*

"Comparison of the acis-base properties of 5- and 6-uracilmethylphosphonate (5Umpa2 and 6Umpa2) and

some related compounds. Evidence for intramolecular hydrogen-bond formation in aqueous solution

between (N1)H and the phosphonate group of 6Umpa2"

J. Chem. Soc., Perkin Trans. 2001, 10, 20052011 (doi: 10.1039/b101078f).

(39) W. Brüning, R. K. O. Sigel, E. Freisinger, B. Lippert*

"Pt(II) binding to N1 of cytosine: Strengthening the Watson-Crick pair with guanine, yet confining its pH

existence range"

Angew. Chem. Int. Ed. 2001, 40, 33973399 (doi: 10.1002/1521-3773(20010917)40:18<3397::AID-

ANIE3397>3.0.CO;2-4).

(38) X. Riera, A. Caubet*, C. López*, V. Moreno, E. Freisinger, M. Willermann, B. Lippert

"Versatility in the mode of coordination [(C), (N,S), (C,N) or (C,N,S)] of the Schiff base:

C6H5CH=NCH2SEt to palladium(II). X-ray crystal structure of

cis-[Pd{C6H5CH=NCH2CH2SEt}Cl2] and [Pd{C6H4CH=NCH2CH2SEt}Cl]"

J. Organomet. Chem. 2001, 629, 97108 (doi: 10.1016/S0022-328X(01)00821-X).


(37) M. S. Lüth, E. Freisinger, B. Lippert*

"Metal-modified nucleobase pairs and triplets as cytosine receptors"

Chem. Eur. J. 2001, 7, 21042113 (doi: 10.1002/1521-3765(20010518)7:10<2104::AID-

CHEM2104>3.0.CO;2-F).

(36) R. K. O. Sigel, S. M. Thompson, E. Freisinger, F. Glahé, B. Lippert*

"Metal-modified nucleobase sextet: Joining four linear metal fragments (trans-a2PtII) and six model

nucleobases to an exceedingly stable entity"

Chem. Eur. J. 2001, 7, 19681980 (doi: 10.1002/1521-3765(20010504)7:9<1968::AID-

CHEM1968>3.0.CO;2-B).

(35) E. Freisinger, A. Schimanski, B. Lippert*

"Thymine-metal ion interactions: Relevance for thymine quartet structures"

J. Biol. Inorg. Chem. 2001, 6, 378389 (doi: 10.1007/s007750100212).

2000 _______________________________________________________________________________________________________________

(34) E. Freisinger, S. Meier, B. Lippert*

"Hydrogen bonding patterns of N(7) platinated guanine: Watson-Crick and different self-pairing motifs in

a tris(9-methylguanine) complex of PtII"

J. Chem. Soc., Dalton Trans. 2000, 32743280 (doi: 10.1039/b004993j).

(33) E. Freisinger, A. Schneider, M. Drumm, A. Hegmans, S. Meier, B. Lippert*

"Exocyclic oxygen atoms of platinated nucleobases as binding sites for alkali metal ions"

J. Chem. Soc., Dalton Trans. 2000, 32813287 (doi: 10.1039/b004906i).

(32) R. K. O. Sigel, E. Freisinger, B. Lippert*

"Effects of N7-methylation, N7-platination, and C8-hydroxylation of guanine on H-bond formation with

cytosine: Platinum coordination strengthens the Watson-Crick pair"

J. Biol. Inorg. Chem. 2000, 5, 287299 (doi: 10.1007/PL00010657).

(31) I. B. Rother, E. Freisinger, A. Erxleben, B. Lippert*

"Trans-a2PtII (a = NH3, CH3NH2) modified purine base pairs and triples: Hydrogen bonding between self-

complementary pairs and triples and heterometal (Ag+) coordination leading to a 1 D helix"


(30) J. A. R Navarro*, E. Freisinger, B. Lippert*

"Self-assembly of palladium(II) and platinum(II) complexes of 2-hydroxypyrimidine to novel

metallacalix[4]arenes. Receptor properties through multiple H-bonding interactions"

Inorg. Chem. 2000, 39, 23012305 (doi: 10.1021/ic991411n).

(29) R.-D. Schnebeck, E. Freisinger, B. Lippert*

"Molecular architecture with 2,2'-bipyrazine and metal ions: Infinite loop and molecular square"

Eur. J. Inorg. Chem. 2000, 6, 11931200 (doi: 10.1002/(SICI)1099-0682(200006)2000:6<1193::AID-

EJIC1193>3.0.CO;2-G).


(28) J. A. R. Navarro*, E. Freisinger, B. Lippert*

"From simple trans-[a2Pt(2-hydroxypyrimidine)2]2+ (a = NH3, CH3NH2) complexes to structures of higher

complexity. Molecular recognition of 2-aminopyrimidine by hydrogen bond formation and reactivity

toward additional metal ions"

Inorg. Chem. 2000, 39, 10591065 (doi: 10.1021/ic9903634).

(27) A. Schneider, E. Freisinger, B. Beck, B. Lippert*

"Ready formation of water-stable PtII-(-NH2)-PdII species through combination of trans-[(NH3)2PtIIL2] (L

= N,N '-heterocycle) and [enPd(H2O)2]2+ "

J. Chem. Soc., Dalton Trans. 2000, 837838 (doi: 10.1039/b000456l).

(26) R.-D. Schnebeck, E. Freisinger, F. Glahé, B. Lippert*

"Molecular architecture based on metal triangles derived from 2,2'-bipyrazine (Bpz) and enMII (M = Pt,

Pd)"

J. Am. Chem. Soc. 2000, 122, 13811390 (doi: 10.1021/ja9931325).

(25) J. A. R. Navarro, E. Freisinger, B. Lippert*

"[(Ethylenediamine)Pt(uracilate)]4 A metal analogue of calix[4]arene: Coordination chemistry of its 1,3-

alternate conformer towards first-row transition-metal ions"

Eur. J. Inorg. Chem. 2000, 1, 147151 (doi: 10. 1002/(SICI)1099-0682(200001)2000:1<147::AID-

EJIC147>3.0.CO;2-I).

1999 _______________________________________________________________________________________________________________

(24) A. Hegmans, E. Zangrando, E. Freisinger, F. Pichierri, L. Randaccio*, C. Mealli*, M. Gerdan, A. X.

Trautwein*, B. Lippert*

"Pt as mediator of strong antiferromagnetic coupling between two CuII ions in a heteronuclear CuIIPtIICuII

complex of the model nucleobase 1-methylcytosinate"

Chem. Eur. J. 1999, 5, 30103018 (doi: 10.1002/(SICI)1521-3765(19991001)5:10<3010::AID-

CHEM3010>3.0.CO;2-O).

(23) S. Cosar, M. B. L. Janik, M. Flock, E. Freisinger, E. Farkas, B. Lippert*

"Mono- and di-nuclear complexes of (trpy)MII (M = Pd, Pt) with the model nucleobase 1-methylcytosine.

Crystal structure and NMR solution studies"

J. Chem. Soc. Dalton Trans. 1999, 23292336.

(22) J. Müller, F. Glahé, E. Freisinger, B. Lippert*

"A major, pH-induced stereochemical switch of pairs of trans-oriented ligands in complexes of trans-a2PtII

(a = NH3, CH3NH2)"

Inorg. Chem. 1999, 38, 31603166 (doi: 10.1021/ic990044c).


"Anion pore structure through packing of molecular triangles"

Chem. Commun. 1999, 675676 (doi: 10.1039/a900964g).


(20) R. K. O. Sigel, M. Sabat*, E. Freisinger, A. Mower, B. Lippert*

"Metal-modified base pairs involving different donor sites of purine nucleobases:

trans-[a2Pt(7,9-DimeG-N1)(9-EtGH-N7)]2+ and trans-[a2Pt(7,9-DimeG-N1)(9-EtG-N7)]+ (a = NH3 or

CH3NH2; 9-EtGH = 9-ethylguanine; 7,9-DimeG = 7,9-dimethylguanine). Possible relevance to metalated

DNA triplex structures"

Inorg. Chem. 1999, 38, 14811490 (doi: 10.1021/ic981005o).

(19) M. B. L. Janik, A. Hegmans, E. Freisinger, B. Lippert*

"Reactivity of an extremely sterically crowded monofunctional Pt complex, [Pt(1-MeC-N3)3(H2O)]2+

(1-MeC = 1-methylcytosine), toward model nucleobases and selectivity toward guanine in single- and

double-stranded deoxyoligonucleotides"

J. Biol. Inorg. Chem. 1999, 4, 130139 (doi: 10.1007/s007750050296).

(18) J. A. R. Navarro, M. B. L. Janik, E. Freisinger, B. Lippert*

"[(Ethylendiamine)Pt(uracilate)]4, a metal analogue of calix[4]arene. Coordination and anion host-guest

chemistry related to its conformational dynamics"

Inorg. Chem. 1999, 38, 426432 (doi: 10.1021/ic9808394).

(17) F. Zamora, H. Witkowski, E. Freisinger, J. Müller, B. Thormann, A. Albinati*, B. Lippert*

"Crystal structures of a protonated form of trans-[Pt(NH3)2(mura)2] and of a derivative containing three

different metal ions, Pt2+, Ag+, and Na+ (mura = 1-methyluracil). Major difference in packing between

heteronuclear pyrimidine nucleobase complexes of cis- and trans-(NH3)2PtII"

J. Chem. Soc. Dalton Trans. 1999, 175182 (doi: 10.1039/a804813d).

(16) R. K. O. Sigel, S. M. Thompson, E. Freisinger, B. Lippert*

"Combining four different model nucleobases (uracil, adenine, guanine, cytosine) via metal binding and H

bond formation in a single compound"

Chem. Commun. 1999, 1920 (doi: 10.1039/a807322h).


"A novel highly charged (+12) anion receptor that encapsulates simultaneously NO3¯ and PF6¯ ions"

Angew. Chem. Int. Edit. 1999, 38, 168171 (doi: 10.1002/(SICI)1521-3773(19990115)38:1/2<168::AID-

ANIE168>3.0.CO;2-6).

1998 _______________________________________________________________________________________________________________

(14) R. K. O. Sigel, E. Freisinger, S. Metzger, B. Lippert*

"Metalated nucleobase quartets: Dimerization of a metal-modified guanine, cytosine pair of trans-

(NH3)2PtII and formation of CH···N hydrogen bonds"

J. Am. Chem. Soc. 1998, 120, 1200012007 (doi: 10.1021/ja981637+).

(13) A. Schimanski, E. Freisinger, A. Erxleben, B. Lippert*

"Interactions between [AuX4]¯ (X = Cl, CN) and cytosine and guanine model nucleobases: Salt formation

with (hemi-) protonated bases, coordination, and oxidative degradation of guanine"



(12) M. S. Lüth, E. Freisinger, F. Glahé, B. Lippert*

"Mixed adenine, guanine nucleobase quartets: Metal-modified forms of an open U and a closed rectangle"

Inorg. Chem. 1998, 37, 50445045 (doi: 10.1021/ic9808495).

(11) A. Hegmans, M. Sabat, I. Baxter, E. Freisinger, B. Lippert*

"Synthetic ways to tris(nucleobase) complexes derived from cis-diammineplatinum(II) and a platinum(II)

complex containig four different ligands, three of which are nucleobases"

Inorg. Chem. 1998, 37, 49214928 (doi: 10.1021/ic9802193).

(10) A. Hegmans, E. Freisinger, E. Zangrando*, A. Ashfar, E. Hübener, T. G. Appleton, B. Lippert*

"Tri- and tetrakis(1-methylcytosine) complexes of PtII: Syntheses and X-ray structures of [Pt(1-MeC-

N3)3Cl]+ and [Pt(1-MeC-N3)4]2+ compounds"


(9) B. Lippert*, P. Amo-Ochoa, W. Brüning, E. Freisinger, M. S. Lüth, S. Meier, C. Meiser, S. Metzger, H.

Rauter, A. Schreiber, R. K. O. Sigel, H. Witkowski

"Creating regular arrangements of nucleobases through metal ion coordination and H bond formation"

Pure Appl. Chem. 1998, 70, 977983.

(8) C. Meiser, E. Freisinger, B. Lippert*

"Dimerization of metalated nucleobase pairs via hydrogen-bond formation: Open metalated base quartets

of mixed adenine-N3, guanine-N7 complexes of trans-(NH3)2PtII with two different guanine-guanine

pairing schemes"

J. Chem. Soc. Dalton Trans. 1998, 20592064 (doi: 10.1039/a801507d).

(7) M. S. Lüth, E. Freisinger, F. Glahé, J. Müller, B. Lippert*

"Taking advantage of right angles in N1,N7-diplatinated purine nucleobases: Toward molecular squares,

rectangles, and meanders"

Inorg. Chem. 1998, 37, 31953203 (doi: 10.1021/ic980081o).

(6) J. Müller, E. Zangrando, N. Pahlke, E. Freisinger, L. Randaccio*, B. Lippert*

"Affinity of the iminooxo tautomer anion of 1-methylcytosine in trans-[Pt(NH3)2(1-MeC-N4)2]2+ for

heterometals"

Chem. Eur. J. 1998, 4, 397405 (doi: 10.1002/(SICI)1521-3765(19980310)4:3<397::AID-

CHEM397>3.0.CO;2-0).

(5) R. K. O. Sigel, E. Freisinger, B. Lippert*

"If Watson-Crick and Hoogsteen sites of guanine are blocked, hydrogen bonding with cytosine is via N2

and N3"

Chem. Commun. 1998, 219220 (doi: 10.1039/a704837h).

1997

_______________________________________________________________________________________________________________

(4) M. Peilert, S. Weißbach, E. Freisinger, V. I. Korsunsky, B. Lippert*

"+3 Oxidation state of platinum in dinuclear complexes with thymine nucleobases: Structural and solution


studies"


(3) H. Witkowski, E. Freisinger, B. Lippert*

"Uracil quartet formation through non-covalent interaction with a neutral metal ammine complex"

Chem. Commun. 1997, 13151316 (doi: 10.1039/a702035j).

(2) H. Rauter, I. Mutikainen*, M. Blomberg, C. J. L. Lock, P. Amo-Ochoa, E. Freisinger, L. Randaccio*, E.

Zangrando, E. Chiarparin, B. Lippert*

"Cyclic metal complexes of nucleobases and other heterocycles: Molecular boxes, rectangles, and

hexagons"

Angew. Chem. Int. Edit. 1997, 36, 12961301 (doi: 10.1002/anie.199712961).

(1) C. Meiser, B. Song, E. Freisinger, M. Peilert, H. Sigel*, B. Lippert*

"The N3 position of N9-substituted adenine as a metal ion binding site: Structural and solution studies with

PdII and PtII complexes of N6',N6',N9-trimethyladenine"


Books ______________________________________________________________________________________________________

E. Freisinger

"Structurelle Untersuchungen zur Koordination von Metallionen an Modellnukleobasen"

Logos Verlag, Berlin, Germany, 2000, 377 pp.

ISBN: 3-89722-416-X

E. Freisinger List of Lectures Page 1/5

Lectures

2013 ______________________________________________________________________________________________________

(44) Invited Lecture: XII International Symposium on Inorganic Biochemistry – Collaboration and Beyond

"New metallothionein sequences: Broadening the range of cluster structures"

Wrocław, Poland, Aug. 28 Sept. 1, 2013.

(43) E. A. Peroza, A. C. S. Cabral, X. Wan, E. Freisinger

"Metal ion release from metallothioneins: Competition, oxidation, and proteolysis"

Oral and Poster Presentation; 16th International Conference on Biological Inorganic Chemistry (ICBIC

16), Grenoble, France, July 22-26, 2013.

(42) Lecture: COST-CM1105 Meeting of Working Group 2

"Site-specific functionalization of larger nucleic acids"

Birmingham, UK, March 56, 2013

(41) Invited Lecture: Bioinorganic Chemistry Conference 2013 (Zing Conferences)

"Novel metallothionein forms: Enlarging the range of cluster structures"

Lanzarote, Spain, Feb. 1922, 2013.

2012 ______________________________________________________________________________________________________

(40) Invited Lecture: 6th Asian Biological Inorganic Chemistry Conference (AsBIC VI)

"Insights into the clusters of plant metallothioneins"

Hong Kong, Nov. 58, 2012.

(39) Invited Lecture: School of Chemistry & Chemical Engineering (Prof. Z.-W. Mao)

"Understanding the structures of plant metallothioneins / Site-specific functionalization of nucleic acids"

Sun Yat-sen University, Guangzhou, China, Nov. 2, 2012.

(38) Lecture: COST-CM1105 Whole Action Meeting

"Site-specific functionalization of larger nucleic acids"

Granada, Spain, Sept. 1718, 2012

(37) Invited Keynote Lecture: 11th European Biological Inorganic Chemistry Conference (EuroBIC 11)

"Understanding the structures of plant metallothioneins"

Granada, Spain, Sept. 1216, 2012.

(36) Lecture: 40th International Conference on Coordination Chemistry (ICCC 40)

"Spectroscopic insights into the smallest possible metal-thiolate cluster"

Valencia, Spain, Sept. 913, 2012.

(35) Invited Lecture: Department of Biology (Prof. H. Küpper)

"Metallothioneins: Storage and detoxification of metal ions"

University of Konstanz, Germany, July 12, 2012.

(34) Invited Lecture: Symposium of Inorganic Chemistry (Department of Chemistry)

"Plant metallothioneins viewed from a bioinorganic perspective and a modular system for site-specific


nucleic acid modifications"

University of Basel, Switzerland, Jan. 2324, 2012.

2011 ______________________________________________________________________________________________________

(33) Lecture: 11th International Symposium on Applied Bioinorganic Chemistry (ISABC 11)

"Recruiting sulfide ligands to increase the detoxification capacity of metallothioneins"

Barcelona, Spain, Dec. 25, 2011.

(32) Lecture: 15th International Conference on Biological Inorganic Chemistry (ICBIC 15)

"The two-domain structure of wheat Zn6Ec-1 and its functional implications"

Vancouver, Canada, Aug 712, 2011.

(31) Invited Lecture: Kolloquium des Graduiertenkollegs 1026 "Conformational transitions in macromolecular

interactions"

"Understanding the structures of plant metallothioneins"

Institute for Biotechnology, Martin-Luther-University Halle-Wittemberg, Halle (Saale), Germany, Jan. 17,

2011.

2010 ______________________________________________________________________________________________________

(30) Lecture: 11th International Symposium on Inorganic Biochemistry

"Oxidation and proteolysis promote release of metal ions from metallothioneins sub-form-specific and to

different extends" (E. A. Peroza, A. C. S. Cabral, X. Wan, E. Freisinger)

Kudowa Zdrój, Poland, Sept. 48, 2010.

(29) Lecture: 10th European Biological Inorganic Chemistry Conference (EuroBIC 10) and COST-D39

"RNA vs. DNA three-way junction formed by the interaction with a metallosupramolecular helicate:

Structural aspects" (J. Schnabl, R. K. O. Sigel, B. Spingler, M. J. Hannon, E. Freisinger)

Thessaloniki, Greece, June 2226, 2010.

2009 ______________________________________________________________________________________________________

(28) Lecture: 10th International Symposium on Applied Bioinorganic Chemistry (ISABC 10)

"The metal-thiolate clusters of plant metallothioneins"

Debrecen, Hungary, Sept. 2528, 2009.

(27) Lecture: 14th International Conference on Biological Inorganic Chemistry (ICBIC 14)

"Wheat Zn4E-Ec-1: The first 3D structure of a plant metallothionein"

Nagoya, Japan, July 2530, 2009 J. Biol. Inorg. Chem. 2009, 14, S80.


(26) Lecture: Reunión Científica Bioinorgánica 2009 (Spanish Bioinorganic Chemistry Meeting)

"Plant MTs: Not just another class of metallothioneins!"

Llucmajor, Mallorca, Spain, July 1518, 2009.

(25) Invited Lecture: Kolloquium des Hochschullehrernachwuchses der Fakultät für Chemie und Biochemie

"Pflanzliche MTs - Stiefkinder der Metallothioninforschung"

University of Bochum, Germany, Jan. 19, 2009.

2008 ______________________________________________________________________________________________________

(24) Invited Keynote Lecture: 9th European Biological Inorganic Chemistry Conference (EuroBIC 9)

"Towards the structure and properties of plant metallothioneins"

Wrocław, Poland, Sept. 26, 2008.

(23) Lecture: 4th EuCheMS Conference on Nitrogen Ligands in Coordination Chemistry, Metal-Organic

Chemistry, Bioinorganic Chemistry and Homogeneous Catalysis

"Plant metallothioneins – Going for histidine ligands"

Garmisch-Partenkirchen, Germany, Aug. 2428, 2008.

2007 ______________________________________________________________________________________________________

(22) Invited Lecture: Department of Biochemistry

"Plant metallothioneins: Differences and analogies to known cluster structures"

University of Zürich, Switzerland, Nov. 22, 2007.

(21) Lecture: COST-D39 Working Group Meeting

"Methods for the investigation of non-covalent metallo-drugs"

University of Birmingham, UK, Oct. 1516, 2007.

(20) Invited Lecture: 13th International Conference on Biological Inorganic Chemistry (ICBIC 13)

"Plant MTs Long neglected members of the metallothionein superfamily"

Vienna, Austria, July 1520, 2007 J. Biol. Inorg. Chem. 2007, 12, S56.

(19) Invited Lecture: Symposium of Inorganic Chemistry (Department of Chemistry)

"Plant metallothioneins provide surprising new insights into the common picture of metal-thiolate clusters"

University of Basel, Switzerland, June 2728, 2007.

(18) Lecture: Chemiedozententagung 2007

"Plant metallothioneins: Differences and analogies to known cluster structures"

Martin-Luther-University of Halle-Wittenberg, Germany, Mar. 1114, 2007.

2006 ______________________________________________________________________________________________________


(17) Invited Lecture: Department of Chemistry

"Plant MTs Long neglected members of the metallothionein superfamily "

University of Zürich, Switzerland, Dec. 45, 2006.

(16) Short Lecture: Swiss Chemical Society – Fall Meeting

"The cluster structure of a wheat metallothionein"

University of Zürich, Switzerland, Oct. 13, 2006 Chimia 2006, 7/8, 406.

(15) Lecture: 3rd Central European Conference on Chemistry Towards Biology

"Plant metallothioneins - A new variety of an old acquaintance"

Jagiellonian University, Kraków, Poland, Sept. 812, 2006.

(14) Invited Lecture: IV International Symposium on Metals, Environment and Health

"A closer look at plant metallothioneins"

Szklarska Poręba, Poland, Sept. 610, 2006.

(13) Short Lecture: EMBL Workshop on the definition of protein domains and their likelihood of crystallization

"Domain structure of a plant metallothionein"

University of Vienna, Austria, June 2830, 2006.

(12) Invited Lecture: Minisymposium: Bioinorganic Chemistry - in Dortmund and Beyond

"Plant metallothioneins - A new variety of an old acquaintance"

University of Dortmund, Germany, Apr. 28, 2006.

(11) Lecture: Chemiedozententagung 2006

"Plant metallothioneins – A new variety of an old acquaintance"

University of Hamburg, Germany, Mar. 1922, 2006.

2005 ______________________________________________________________________________________________________

(10) Invited Lecture: Vertiefungskurs Bio-An/Organische Chemie (14.11.23.12.2005)

"Plant metallothioneins"

Konstanz, Germany, Nov. 18, 2005 (coordinators S. Ghisla/P. Kroneck).

2004 ______________________________________________________________________________________________________

(9) Invited Lecture: Annual Meeting of the Swiss Society for Crystallography (SSCR 2004)

"Lesion (in)tolerance of a DNA polymerase at the molecular level"

Neuchâtel, Switzerland, Oct. 6, 2004.

2003 ______________________________________________________________________________________________________


(8) Invited Lecture: F. HoffmannLa Roche AG


Basel, Switzerland, Jan. 6, 2003.

2002 ______________________________________________________________________________________________________

(7) Lecture: EMBL Practical course on high throughput crystallisation

"Replicating complex of RB69 gp43 DNA polymerase and damaged DNA"

EMBL Heidelberg, Germany, May, 2002.

(6) Invited Lecture: Novartis International AG

"Structural insights into the replicating of undamaged and damaged DNA"

Basel, Switzerland, May 17, 2002.

(5) Invited Lecture: Institute of Inorganic Chemistry

"Structural insights into the replicating of undamaged and damaged DNA"

University of Zürich, Switzerland, June 17, 2002.

2000 ______________________________________________________________________________________________________

(4) Invited Lecture: New York University Medical Center

"Structural investigations of the coordination of metal ions to model nucleobases"

New York University, New York, NY, USA, Mar., 2000.

(3) Invited Lecture: Cold Spring Harbor Laboratory


Cold Spring Harbor, NY, USA, Mar., 2000.

(2) Invited Lecture: Center for Structural Biology


State University of New York at Stony Brook, NY, USA, Mar., 2000.

1999 ______________________________________________________________________________________________________

(1) Lecture: COST-D8 Working Group Meeting

E. Freisinger, A. Fichtel, A. Hegmans, M. S. Lüth, S. Meier, J. Müller, B. Lippert

"Complexes of platinum with the modelnucleobases 9-MeGH/9-EtGH and 1-MeC displaying the trans-

oriented nucleobases in the unusual head,head-conformation: An X-ray study"

Oxford, UK, Mar. 2627, 1999.

E. Freisinger List of Abstracts from Conferences Page 1/16

Contributions to Conferences: Poster and Co-authored Lectures (the presenting author is underlined)

2013 ______________________________________________________________________________________________________

(130) I. A. Oleinich, E. Freisinger

"A modular system for point-specific labeling of native oligonucleotides"

Oral Presentation; COST-CM1105 Whole Action and WG2 Meeting

Barcelona, Spain, Sept. 9-10, 2013

(129) D. Egloff, E. Freisinger

"Synthesis of site-specifically functionalized etheno-DNA"

Poster Presentation; COST-CM1105 Whole Action and WG2 Meeting

Barcelona, Spain, Sept. 9-10, 2013


"A modular system for point-specific labeling of native oligonucleotides"

Poster Presentation; Swiss Chemical Society Fall Meeting (SCS 2013)

Ecole Polytechnique Fédérale de Lausanne, Switzerland, Sept. 6, 2013 Chimia 2013, 67, 537.


"Development of a new method for site-specific etheno-DNA synthesis"



(126) J. Jakovleska, E. Freisinger

"Understanding metal ion binding ability, thermodynamic stability and structure of a metallothionein from

Musa acuminata (banana)"



(125) K. Tarasava, E. Freisinger

"Non-natural analogs of a wheat metallothionein"

Oral Presentation; Swiss Chemical Society Fall Meeting (SCS 2013)


(124) J. Jakovleska, E. Freisinger

"Understanding the structure of metal complexes formed by a plant metallothionein from Musa

acuminata"

Poster Presentation; 12th International Symposium on Inorganic Biochemistry

Wrocław, Poland, Aug. 28-Sept. 1, 2013.


"Artificial analogs of the -domain from the wheat metallothionein Ec-1"




(122) A. Salim, J. Loebus, E. Freisinger

"Spectroscopic properties of the fungal metallothionein Neclu_MT2"

Oral Presentation; 12th International Symposium on Inorganic Biochemistry


(121) J. Loebus, B. Leitenmaier, E. Freisinger

"Spectroscopic studies on the CdII specific metallothionein Neclu_MT1"

Oral Presentation; 12th International Symposium on Inorganic Biochemistry


(120) E. A. Peroza, A. C. S. Cabral, X. Wan, E. Freisinger

"Metal ion release from metallothioneins: Competition, oxidation, and proteolysis"

Oral and Poster Presentation; 16th International Conference on Biological Inorganic Chemistry (ICBIC

16), Grenoble, France, July 22-26, 2013.


"Non-natural analogs of a wheat metallothionein"

Poster Presentation; 16th International Conference on Biological Inorganic Chemistry (ICBIC 16)

Grenoble, France, July 22-26, 2013.

(118) J. Loebus, B. Leitenmaier, H. Küpper, D. Meissner, B. Braha, G.-J. Krauss, D. Dobritzsch, E. Freisinger

"The first CdII specific metallothionein Neclu_MT1 confers CdII tolerance to Heliscus lugdunensis:

Physiological and structural characterization"

Poster Presentation; FEMS 2013 (5th Congress of European Microbiologists)

Leipzig, Germany, July 21-25, 2013

(117) J. Loebus, S. Johannsen, E. Freisinger

"GHOST - A GST hydrogel system for spectroscopic characterization and rapid NMR structure

determination of small proteins"

Oral Presentation; 4th International Symposium on Metallomics

Oviedo, Spain, July 8-11, 2013


"In-situ formation of fluorescent etheno-nucleobase"

Poster Presentation; 5th European Conference on Chemistry for Life Sciences (5th ECCLS)

Barcelona, Spain, June 10-12, 2013


"Modular system for site-specific labeling of native oligonucleotides"

Poster Presentation; Symposium on Biomolecular Synthesis and Nanotechnology

University of Southern Denmark, Odene, Denmark, June 3-4, 2013.

2012 ______________________________________________________________________________________________________


"Site-directed etheno adenine formation"


Poster Presentation; 7th Annual Dorothy Crowfoot-Hodgkin Symposium

University of Zürich, Switzerland, Oct. 8, 2012.


"Cyclic analog of the γ-Ec-1 metallothionein domain"




"A modular system for the post-synthetic point-specific labeling of natural nucleic acids"


ETH Zürich-Hönggerberg, Switzerland, Sept. 13, 2012 Chimia 2012, 66, 602.


"Etheno-adenine generation at specific sites"



(110) S. Johannsen, J. Loebus, E. Freisinger

"Probing of the metallation-process from the ZnII-to the CdII-form of the -Ec-1 metallothionein by NMR

spectroscopy"



(109) T. Huber, E. Freisinger

"Investigations on the metal-sulfide-thiolate cluster of metallothioneins"




"Cyclic analog of the γ-Ec-1 metallothionein domain"

Poster Presentation; 11th European Biological Inorganic Chemistry Conference (EuroBIC 11)


(107) J. Loebus, B. A. Leitenmaier, D. Meissner, D. Wesenberg, E. Freisinger

"A protein from the aquatic fungus Heliscus lugdunensis is the first cadmium specific metallothionein"

Oral Presentation; 11th European Biological Inorganic Chemistry Conference (EuroBIC 11)


(106) J. Loebus, B. A. Leitenmaier, D. Meissner, D. Wesenberg, E. Freisinger

"GST fusion protein facilitates NMR structure solution and spectrosocpical characterization of small

proteins"

Poster Presentation; International Conference on Magnetic Resonance in Biological Systems

Lyon, France, Aug. 19-24, 2012.


"Site-directed etheno adenine formation"

Poster Presentation; XX International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (XX IRT)

Montreal, Quebec, Canada, Aug. 5-9, 2012.



"A modular system of the incorporation of point-specific modifications into larger nucleic acids"

Poster Presentation; XX International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (XX IRT)

Montreal, Quebec, Canada, Aug. 5-9, 2012.


"Mechanism of sulfide ion incorporation into the metal cluster of metallothioneins"

Poster Presentation; International Symposium on Metal Complexes (ISMEC2012)

Lisbon, Portugal, June 18-22, 2012.

2011 ______________________________________________________________________________________________________

(102) S. Johannsen, J. Loebus, E. Freisinger

"Site specific metallation of a metallothionein from wheat"

Poster Presentation; 11th International Symposium on Applied Bioinorganic Chemistry (ISABC 11)

Barcelona, Spain, Dec. 25, 2011.

(101) J. Schnabl, E. Freisinger, B. Spingler, M. J. Hannon, R. K. O. Sigel

"Dinuclear supramolecular iron(II) cylinders: Three-way junctions in RNA"




"Insights into plant metallothioneins: metal clusters and their functional aspect"




"The cyclic analog of the wheat metallothionein -Ec-1 domain"



(98) B. Leitenmaier, E. Freisinger

"Folding properties of metallothionein Ec-1 from wheat (Triticum aestivum) investigated by intrinsic

tryptophan fluorescence"




"The cyclic analog of the wheat metallothionein -Ec-1 domain"




"Site-specific transamination of cytidine"




(95) J. Loebus, T. Fox, S. Johannsen, E. Freisinger

"A distinct zinc and cadmium binding site in the mixed MII2Cys6 metal cluster of the -Ec-1

metallothionein"




"Targeted -base formation in nucleic acids"




"Metal cluster and functional analysis of plant metallothioneins"




"Dinuclear supramolecular iron(II) cylinders: Three-way junctions in RNA"

Poster presentation; 5th EuCheMS Conference on Nitrogen Ligands

Granada, Spain, Sept. 4-8 2011.


"Site-specific generation of ε-adducts in nucleic acids"


Vancouver, Canada, Aug 7-12, 2011.


"Insights into plant metallothioneins: metal clusters and their functional aspects"


Vancouver, Canada, Aug 7-12, 2011.


"Supramolecular iron(II) cylinders inside RNA three-way junctions - a step into non-covalent RNA

targeting"

Short Lecture; COST-D39 Action Meeting

Dublin, Ireland, July 56, 2011.

(88) J. Loebus, E. A. Peroza, N. Blüthgen, T. Fox, W. Meyer-Klaucke, O. Zerbe, E. Freisinger

"Protein and metal cluster structure of the -domain of the plant metallothionein Ec-1 from bread wheat"

Lecture; 3rd International Symposium on Metallomics

Münster, Germany, Jun. 15-18, 2011

(87) J. Loebus, D. Göhler, D. Wesenberg, G. J. Krauss, E. Freisinger

"Purifying plant metallothioneins - Challenges and shortcuts"

Lecture; ANAKON 2011 (Konferenz Analytische Chemie der GdCh)

ETH Zürich-Hönggerberg, Switzerland, Mar. 22-25, 2011


(86) J. Loebus, D. Göhler, D. Wesenberg, G. J. Krauss, E. Freisinger

"Opportunities and challenges when purifying metallothioneins"

Short Lecture; 21. Doktorandenseminar der GdCh-Fachgruppe "Analytische Chemie"

Hohenroda, Germany, Jan. 9-11, 2011 Lecture prize award.

2010 ______________________________________________________________________________________________________


"Switching on fluorescence selectively at cytosine bases"



(84) T. Huber, X. Wan, E. Freisinger

"Sulfide ions elevate the metal binding capacity of cicMT2"




"Site-specific incorporation of ε-adenine into DNA"


ETH Zürich-Hönggerberg, Switzerland, Sept. 16, 2010 Chimia 2010, 7/8, 546.


"The plant metallothionein 2 from Cicer arietinum increases its metal ion binding capacity by

incorporation of sulfide ions"



(81) J. Loebus, O. Zerbe, D. Wesenberg, G. J. Krauss, E. Freisinger

"Spectroscopic and spectrometric characterization of the fungal metallothionein necluMT1 from Heliscus

lugdunensis"




"Switching on fluorescence selectively at cytosine bases"




"RNA forms a three-way junction with a supramolecular iron(II) cylinder"

Short lecture; Swiss Chemical Society Fall Meeting (SCS 2010)



"Sulfide ions elevate the metal binding capacity of cicMT2"




(77) J. Loebus, E.A. Peroza, E. Freisinger, O. Zerbe

"NMR solution structure of the γ-domain of the plant metallothionein Ec-1 from bread wheat"



(76) J. Loebus, O. Zerbe, D. Wesenberg, G. J. Krauss, E. Freisinger

"Evidence towards a better understanding of metal ion and ligand specificity in metallothioneins using

necluMT1 from Heliscus lugdunensis"




"A supramolecular iron(II) helicate induces a RNA three-way junction"



2009 ______________________________________________________________________________________________________

(74) A. C. S. Cabral, E. Freisinger

"Metal ion binding ability of the metallothionein 3 from Musa acuminata (banana)"


Debrecen, Hungary, Sept. 2528, 2009.

(73) A. Galstyan, P. Sanz Miguel, E. Freisinger, B. Lippert

"Of triangles, vases and boxes: 2,2’-bipyrazine complexes of cis-a2MII (a = NH3 or a2 = en; M = Pt or Pd)"


Debrecen, Hungary, Sept. 2428, 2009

(72) J. Schnabl, A. M. Rich, R. K. O. Sigel, M. J. Hannon, E. Freisinger

"Crystallization of triple-stranded iron(II) helicates with RNA"

Poster Presentation; COST-D39 Action Meeting


(71) A. Galstyan, P. Sanz Miguel, E. Freisinger, B. Lippert

"Of triangles, vases and boxes: 2,2’-bipyrazine complexes of cis-a2MII (a = NH3 or a2 = en; M = Pt or Pd)"

Short Lecture; COST-D39 Action Meeting


(70) J. Loebus, E. Freisinger

"Structural and functional characterisation of plant metallothionein Ec-1"

Poster Presentation; FEBS course PLC09-060 (Chemistry of Metals in Biological Systems)

Louvain-la-Neuve, Belgium, Sept. 1421, 2009.


(69) J. Schnabl, E. Freisinger, M. J. Hannon, R. K. O. Sigel

"Crystallization of triple-stranded iron(II) helicates with RNA"

Poster Presentation; FEBS course PLC09-060 (Chemistry of Metals in Biological Systems)

Louvain-la-Neuve, Belgium, Sept. 1421, 2009 Poster prize award.


"Metal binding ability and stability of a metallothionein from Synechococcus vulcanus"


Ecole Polytechnique Fédérale de Lausanne, Switzerland, Sept. 4, 2009 Chimia 2009, 7/8, 420.

(67) E. A. Peroza, S. Chesnov, E. Freisinger

"Ec-1 from wheat: Exploring a unique metallothionein"



(66) E. Freisinger

"Wheat Zn4E-Ec-1: The first 3D structure of a plant metallothionein"

Poster Presentation and Lecture; 14th International Conference on Biological Inorganic Chemistry (ICBIC

14)

Nagoya, Japan, July 25-30, 2009 J. Biol. Inorg. Chem. 2009, 14, S80.

2008 ______________________________________________________________________________________________________

(65) E. A. Peroza, P.Schmucki, P. Güntert, O. Zerbe, E. Freisinger

"Solution structure of the E-domain of wheat Ec-1: A metallothionein with unusual metal binding centers"

Poster Presentation; 4th Asian Biological Inorganic Chemistry Conference (AsBIC IV)

Jeju Island, Korea, Nov. 11-13, 2008.

(64) E. A. Peroza, P.Schmucki, P. Güntert, E. Freisinger, O. Zerbe

"Solution structure of the C-terminal domain of wheat Ec-1: A metallothionein exhibiting unusual metal-

binding centers"

Poster Presentation; 6th International NCCR Symposium on New Trends in Structural Biology

University of Zürich, Switzerland, Sept. 8-9, 2008.


"New insights into the structure and properties of Musa acuminata MT3"


University of Zürich, Switzerland, Sept. 11, 2008 Chimia 2008, 7/8, 603.

(62) E. A. Peroza, N. Blüthgen, W. Meyer-Klaucke, G. Wellenreuther, S. Chesnov, E. Freisinger

"Ec-1 from wheat: A metallothionein featuring unique metal-binding domains"


University of Zürich, Switzerland, Sept. 11, 2008 Chimia 2008, 7/8, 614.

(61) A. C. S. Cabral, P. Antoni, E. Freisinger

"Insights into the properties of metallothioneins by ITC analysis under anaerobic conditions"


Poster Presentation; Applications of BioCalorimetry(abc6)

Heidelberg, Germany, July 710, 2008.

(60) A. C. S. Cabral,, E. Freisinger

"Metal ion coordination studies with Musa acuminata MT3"

Poster Presentation; 3rd Annual Dorothy Crowfoot-Hodgkin Symposium

University of Zürich, Switzerland, May 9, 2008.

(59) E. A. Peroza, E. Freisinger

"Wheat Ec-1 MT: Metal-binding domains and a comparison with other plant metallothioneins"



(58) X. Wan, E. Freisinger

"Discrimination of metal ions by Cicer arietinum metallothionein 2"



2007 ______________________________________________________________________________________________________


"Histidine versus cysteine coordination of metal ions in the metallothionein Musa acuminata MT3"



(56) A. Al Kaabi, E. A. Peroza, E. Freisinger

"Investigation of metal-thiolate clusters in the wheat Ec-l plant metallothionein by mass spectrometry"




"A closer view at the wheat metallothionein Ec-1 and an evaluation and comparison of its redox properties"

Short Lecture; Swiss Chemical Society Fall Meeting (SCS 2007)



"Copper coordination to the plant metallothionein Cicer arietinum MT2"




"Wheat Ec-1 MT: A detailed view and a comparison with other plant metallothioneins"




"Typical and untypical metal ion binding modes in Cicer arietinum metallothionein 2"




(51) B. Lippert, E. G. Bardaji, E. Freisinger

"Molecular architectures with pyrimidine nucleobases and cis-a2MII (M = Pt, Pd; a = NH3 or a2 = diamine)"

Lecture; 13th International Conference on Biological Inorganic Chemistry (ICBIC 13)


(50) E. Freisinger

"Pflanzliche MTs – Stiefkinder der Metallothioninforschung"

Poster Presentation; Symposium zum Forschungskredit der Universität Zürich

University of Zürich, Switzerland, June 26, 2007.

(49) A. C. S. Cabral,, E. Freisinger

"Evaluation of the metal-thiolate cluster in the plant metallothionein M. acuminata MT3"

Poster Presentation; 2nd Annual Dorothy Crowfoot-Hodgkin Symposium

University of Zürich, Switzerland, Apr. 27, 2007.


"A closer view at the wheat metallothionein Ec-1"



(47) O. Schicht, E. Freisinger

"New insights into plant metallothioneins from C. arietinum MT1"




"Cluster structure in a typical p2 plant metallothionein"



2006 ______________________________________________________________________________________________________


"Cluster organization in metallothionein 2 from Cicer arietinum"

Poster Presentation; 3rd Asian Biological Inorganic Chemistry Conference (AsBIC III)

Nanjing, P.R. China, Oct. 30Nov. 3, 2006.


"Metal binding properties of metallothionein 1 from Cicer arietinum"

Poster Presentation; 3rd Asian Biological Inorganic Chemistry Conference (AsBIC III)

Nanjing, P.R. China, Oct. 30Nov. 3, 2006.

(43) E. Peroza, E. Freisinger

"Metal cluster arrangement in wheat Ec-1 metallothionein"





"Diverse cluster composition found in metallothionein 2 from chickpea (Cicer arietinum)"




"Insertion of heavy metal ions into metallothionein 1 from C. arietinum"




"Wheat Ec-1 metallothionein: Evidence for two separate metal clusters"

Poster Presentation; 8th European Biological Inorganic Chemistry Conference (EUROBIC 8)

Aveiro, Portugal, July 26, 2006.


"Metal uptake of plant metallothionein 1 from Cicer arietinum"


Aveiro, Portugal, July 26, 2006.

2005 ______________________________________________________________________________________________________

(38) E. Freisinger

"Metal binding to a fruit-specific metallothionein"


Ecole Polytechnique Fédérale de Lausanne, Switzerland, Oct. 13, 2005 Chimia 2005, 9, 626.


"Metal binding of wheat Ec-1 metallothionein"




"Metal binding affinity of metallothionein 2 from chickpea"



(35) E. Freisinger

"Spectroscopic characterization of a fruit-specific metallothionein"

Poster Presentation; 10th International Symposium on Bioinorganic Chemistry




"Wheat Ec-1 metallothionein: Metal affinities"

Poster Presentation; 10th International Symposium on Bioinorganic Chemistry


(33) E. Freisinger

"Metal binding properties of a novel plant metallothionein"


Ann Arbor, MI, USA, July 31Aug. 5, 2005.

2004 ______________________________________________________________________________________________________

(32) E. Freisinger

"Lesion (in)tolerance of a DNA polymerase at the molecular level"

Poster Presentation; Annual Meeting of the Swiss Society for Crystallography (SSCR 2004)

Neuchâtel, Switzerland, Oct. 6, 2004.

(31) B. Probst, E. Freisinger

"Characterization of a novel plant metalloprotein: M. acuminata MT3"


Garmisch-Partenkirchen, Germany, Aug. 29Sept. 2, 2004.

2002 ______________________________________________________________________________________________________

(30) B. Lippert, R. Nowak, M. S. Lüth, R. K. O. Sigel, I. Rother, M. Roitzsch, W. Brüning, E. Freisinger, M.

Willermann

"Molecular Architectures with metal ions and nucleobases "

Lecture; 35th International Conference on Coordination Chemistry (ICCC 35)

Heidelberg, Germany, July 2126, 2002.

2001 ______________________________________________________________________________________________________

(29) E. Freisinger, B. Lippert

"Relevance of alkali metal ions for the formation of thymine quartet structures: An X-ray study"


Florence, Italy, Aug. 2631, 2001 J. Inorg. Biochem. 2001, 86, 222.

1999 _______________________________________________________________________________________________________________


(28) I. B. Rother, E. Freisinger, A. Erxleben, B. Lippert

"Molecular recognition of platinated purine nucleobases: X-ray and solution structures of nucleobase

quartets and sextets formed through H bonding"

Poster Presentation; Sonderforschungsbereich (SFB) 436 Congress 1999 "Metal Mediated Reactions

Modelled after Nature"

Jena, Germany, Sept. 1216, 1999.

(27) B. Lippert, M. S. Lüth, R.-D. Schnebeck, I. Rother, R. K. O. Sigel, J. A. Navarro, A. Fichtel, E.

Freisinger.

"Molecular architecture with metals, nucleobases, and other heterocycles"

Poster Presentation; Post-Conference Symposium of the 26th International Conference on Solution

Chemistry (26 ICSC)

Nagoya, Japan, Aug. 23, 1999.

(26) R. K. O. Sigel, E. Freisinger, B. Lippert

"Towards cationic di- and trinucleotide analogs with a platinum(II) backbone"


Minneapolis, USA, July 1116, 1999 J. Inorg. Biochem. 1999, 74, 296.

(25) M. Drumm, E. Freisinger, M. S. Lüth, E. Sletten, B. Lippert

"Structural characterization of short oligonucleotides modified with trans-a2Pt(II) by NMR"


Minneapolis, USA, July 1116, 1999 J. Inorg. Biochem. 1999, 74, 119.

(24) R. K. O. Sigel, E. Freisinger, B. Lippert.

"Association of PtII-nucleobase complexes in solution and in the solid state via two, three, four, or five

hydrogen bonds"

Lecture; 5th International Symposium on Applied Bioinorganic Chemistry (ISABC 5)

Corfu, Greece, Apr. 1317, 1999.

(23) E. Freisinger, A. Fichtel, A. Hegmans, M. S. Lüth, J. Müller, B. Lippert

"Different ways of stabilization of the head,head-conformation in trans-oriented nucleobases in complexes

of platinum: X-ray studies"



(22) B. Lippert, M. B. L. Janik, J. Müller, R. K. O. Sigel, E. Freisinger

"Synthetic strategies to and properties of trans-diam(m)ineplatinum(II) modified oligonucleotides"



(21) J. Ochocki, J. Graczyk, E. Freisinger, B. Lippert

"Synergistic activity of cisplatin and phosphonate pyrimidine analogues against leukaemia L1210. Crystal

and molecular structure of 6-umpm and 6-umpa"


Corfu, Greece, Apr. 1317, 1999



"Association of PtII-nucleobase complexes in solution and in the solid state via two, three, four, or five

hydrogen bonds"

Lecture; COST-D8 Working Group Meeting, Oxford, UK, Mar. 2627, 1999.

(19) M. B. L. Janik, J. Müller, R. K. O. Sigel, E. Freisinger, B. Lippert

"Towards a possible use of trans-a2PtII in antisense and antigene reagents: Model studies with isolated

nucleobases and DNA-fragments"

Lecture; 8th International Symposium on Platinum and other Metal Coordination Compounds in Cancer

Chemotherapy, Oxford, UK, Mar. 29Apr. 1, 1999.

1998 _______________________________________________________________________________________________________________

(18) P. Amo-Ochoa, E. Freisinger, B. Lippert

"A molecular hexagon made of platinum, mercury, and four nucleobases"


Sevilla, Spain, July 2125, 1998

(17) B. Lippert, E. Freisinger, F. Glahé, M. B. L. Janik, M. S. Lüth, S. Meier, C. Meiser, K. Schmidt, R. K. O.

Sigel, S. M. Thompson

"Multiple-stranded nucleic acids: Trying to understand the role of metal ions"

Plenary Lecture; 4th European Biological Inorganic Chemistry Conference (EUROBIC 4)

Sevilla, Spain, July 2125, 1998.

(16) J. Müller, F. Glahé, E. Freisinger, E. Zangrando, L. Randaccio, B. Lippert


heterometals"



(15) X. Riera, V. Moreno, E. Freisinger, B. Lippert

"Pd(II) and Pt(II) complexes of 3-aminopyrrolidine. Structural study and DNA reactivity"


Sevilla, Spain, July 2125, 1998.


"Hydrogen bonding properties of guanine derivatives and effect of platinum(II)"

Session Lecture; 4th European Biological Inorganic Chemistry Conference (EUROBIC 4)


(13) F. Zamora, H. Witkowski, E. Freisinger, J. Müller, B. Thormann, A. Albinati, B. Lippert

"Protonation of and reactivity toward metal ions of trans-Pt(NH3)2(1-MeU)2"




(12) M. S. Lüth, E. Freisinger, F. Glahé, B. Lippert

"Molecular architecture of a closed rectangle with nucleobases: Syntheses and X-ray structures of metal-

modified quartets"

Poster Presentation; 33rd International Conference on Coordination Chemistry (ICCC 33)

Florence, Italy, Aug. 30Sept. 4, 1998

(11) J. A. R. Navarro, E. Freisinger, M. B. L. Janik, B. Lippert

"[(Ethylendiamine)Pt(uracilate)]4: A metal analogue of calix[4]arene. Coordination and anion host-guest



Florence, Italy, Aug. 30Sept. 4, 1998.


"A new hydrogen bonding pattern and effect of platinum(II) on the properties of guanine derivatives"



(9) R.-D. Schnebeck, E. Freisinger, L. Randaccio, E. Zangrando, B. Lippert

"Molecular architecture with 2,2'-bipyrazine and metal ions: Triangles, molecular vase, and anion

receptor"



(8) J. A. R. Navarro, E. Freisinger, M. B. L. Janik, B. Lippert

"[(Ethylendiamine)Pt(uracilate)]4: A metal analogue of calix[4]arene. Coordination and anion host-guest


Lecture; COST-D8 Working Group Meeting, University of Dortmund, Germany, Sept. 1819, 1998.

(7) R. K. O. Sigel, E. Freisinger, S. M. Thompson, B. Lippert

"Effect of platinum(II) coordination on the hydrogen bonding properties of guanine derivatives"

Lecture; COST-D8 Working Group Meeting, University of Dortmund, Germany, Sept. 1819, 1998.

(6) A. Fichtel, E. Freisinger, B. Lippert

"EnPd(II): An unexpected reagent for NH activation of trans-Pt(NH3)2L2 complexes"

Poster Presentation; COST-D8 Working Group Meeting, University of Dortmund, Germany, Sept. 1819,

1998.

(5) E. Freisinger, A. Schimanski, B. Lippert

"[AuX4]¯ An exclusive anion for salt formation of neutral and hemiprotonated nucleobase pairs"


1998.

(4) G. Kampf, E. Freisinger, B. Lippert

"Dinuclear platinum(III) compounds"


1998.


(3) J. Müller, F. Glahé, E. Freisinger, E. Zangrando, L. Randaccio, B. Lippert


heterometals"


1998.

(2) R.-D. Schnebeck, E. Freisinger, L. Randaccio, E. Zangrando, B. Lippert

"Molecular architecture with 2,2'-bipyrazine and metal ions: Triangles, a molecular vase, and anion

receptor"


1998.

1997 _______________________________________________________________________________________________________________

(1) R. K. O. Sigel, S. Metzger, E. Freisinger, B. Lippert

"A metalated guanine-cytosine base quartet: Comparison of the solid state and solution structure"

Contribuciones Cientificas y Tecnologicas 1997, 26, 79.

Poster Presentation; 32nd International Conference on Coordination Chemistry (ICCC 32)

Santiago de Chile, Chile, Aug. 2429, 1997.

Documents

List of Publications, Lectures, and Contributions to ...List of Publications, Lectures, and Contributions to Conferences, Prof. Dr. Eva Freisinger (* denotes the corresponding author)