Life magazine, June 4, 1945, vol. 18, page 45-

46 .

Antigenic Switching

From “Malaria: molecular and clinical analysis”

(M. Walhgren and P. Perlmann, eds.)

Miller, et al., Science, 264: 1878-1883.

Deitsch, K.W. and Hviid, L. (2004), Trends in Parasitology, 20: 562-566

Exon I 5-7 Kb

(hypervariable)

Exon II ~2 Kb

(conserved)Transcription start site

Intron ~1 Kb

+1

Full length mRNA

"Sterile" RNA

Typical var Gene

~60 var genes in each parasite’s genome;

only 1 is transcriptionally active

From: Kyes et al. (2003), Molecular Microbiology 48: 1339-1348.

Smith and Deitsch, J. Exp. Med. 2004;200:1093-1097