Leah (Larisa) Gheber March, 2017 CURRICULUM VITAE AND LIST …in.bgu.ac.il/en/natural_science/chem/lgheber/Documents/CV... · 2017-03-22 · Dr. Sudhir Kumar Singh – Postdoctoral

Leah (Larisa) Gheber March, 2017

CURRICULUM VITAE AND LIST OF PUBLICATIONS

• Personal Details

Name: Leah (Larisa) Gheber

Marital Status: Married, three children

Date and place of birth: January 18, 1964, Ukraine

Date of immigration: August, 1974

Regular military service: 1982-1984

Address and telephone number at work:

Department of Chemistry, the Marcus Campus, 62/119, Beer-Sheva, 84105, Israel

+972-8-6461183

Address and telephone number at home: Haruv 7 Omer, 84965, Israel

+972-8-6437583

• Education

B.Sc. 1984-1987 Ben-Gurion University of the Negev, Beer-Sheva, Israel, Department of Chemistry, Faculty of Natural Sciences, Cum Laude

M.Sc. 1987-1990 Ben-Gurion University of the Negev, Beer-Sheva, Israel, Department of Chemistry , Summa Cum Laude. Adviser: Prof. Zvi Priel. Title of thesis: The properties of the metachronal wave

Ph.D. 1990-1995 Ben-Gurion University of the Negev, Beer-Sheva, Israel. Department of Chemistry. Adviser: Prof. Zvi Priel. Thesis title: Full

characterization of mucociliary activity in vitro

Post doctorate 1995 – 1999 The Johns Hopkins University, Baltimore, Maryland, USA, Department of Biology. Adviser: Prof. M. Andrew Hoyt

• Employment History (in reverse chronological order, including sabbatical leave)

2015 – present Associate Professor, Departments of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

2012 - 2015 Senior Lecturer, tenured, Departments of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

2014 – 2015 Visiting Faculty, sabbatical leave, Department of Molecular and

Cellular Biology, UC Davis, Davis, CA, USA

2010 - 2012 Senior Lecturer, Departments of Clinical Biochemistry and Chemistry, Faculties of Health and Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

2005 - 2010 Lecturer, Departments of Clinical Biochemistry and Chemistry, Faculties of Health and Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

1999 - 2005 Lecturer and Gastroenterology Laboratory Director, Departments of Clinical Biochemistry and Gastroenterology, Faculty of Health

Leah (Larisa) Gheber page 2 February, 2016

Sciences, Ben-Gurion University of the Negev and Soroka University

Medical Center, Beer-Sheva, Israel.

1995 - 1999 Postdoctoral fellow, Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.

1986 - 1995 Instructor and Research Assistant, Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

• Professional Activities (in reverse chronological order)

Positions in academic administration (departmental, faculty and university)

2016 – present Member of the Ethics Committee, BGU

2016 – present Head of the B.Sc. teaching committee, Chemistry, BGU

2015 – present Biophysical Track Coordinator, Teaching committee, Department of Chemistry, BGU

2012 – 2014 Member of the University Centers Committee, BGU

2012 – 2014 Head of the Undergraduate Teaching Committee, Department of Chemistry, BGU

2012 –2013 Biophysical and Organic Chemistry Seminar Coordinator, Department of Chemistry, BGU

2011 – 2012 Teaching Committee, M.Sc. Students, Basic Science Division, Faculty of Health Sciences, BGU

2011 – 2012 Seminar Coordinator, Ilse Katz Institute for Nanoscale Science and

Technology, BGU

2010 – 2011 Seminar Coordinator, Clinical Biochemistry Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, BGU

2008 – 2011 Coordinator of the Biophysical Chemistry Track, Department of Chemistry, Faculty of Natural Sciences, BGU

2008 – 2010 Teaching Committee, M.Sc. Students, Chemistry Department, Faculty of Natural Sciences, BGU

2003 – 2006 Seminar Coordinator, Clinical Biochemistry Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, BGU

2003 – 2011 Teaching Committee, School of Medical Laboratory Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, BGU

2006 – 2011 Committee on Admission for the Prospective Medicine Students, Faculty of

Health sciences, BGU

Professional functions outside universities/institutions 2017 Organizing Committee, The annual meeting of the Israeli Group for Yeast research,

2017, Beer-Sheva, Israel 2017 Organizing Committee and Session Chair, ILANIT, 2017, Eilat, Israel 2016 Organizing Committee, The annual meeting of the Israeli Biophysical Society, 2017,

Beer-Sheva, Israel 2014 Organizing Committee and Session Chair, Systems-Level View of Cytoskeletal

Function, Stockholm, Sweden, 2014


2014 Member of ISF review committee

2013 Session Chair, Microscopy at the Frontier of Science, Tarragona, Spain, September 2013

2013 Session Chair, Batsheva de Rothschild Seminar on Soft Matter and Biophysics, Ben Gurion University and the Dead Sea 10-14, February 2013

2013 Organizing Committee, The Annual Meeting of the Israeli Live Imaging Forum on Super-Resolution and Advanced Imaging, June 25, 2013

2012 Organizing Committee, 46th Annual meeting of the Israeli Society for Microscopy, Beer-Sheva, Israel

2012 – 2014 Board member of the Israeli Society of Biophysics

2012 – present Initiator and Steering Committee Member of the Israeli Forum for Cellular and Cytoskeleton Motility (IFCCM)

2003-2013 Review for journals: Journal of Biological Chemistry; Food and Chemical Toxicology; Life Sciences; Biophysical Journal; Plos One

2003 – 2014 Review of several grant proposals for ISF, GIF, BSF, Israeli Ministry of Health and the Israeli Cancer association

2008 Session Chair, Intracellular Motility and Cell Division, The 5th Congress of the Federation of the Israel Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2008

2005 Organizing Committee, 39th Annual meeting of the Israeli Society for Microscopy, Beer-Sheva, Israel

Membership in professional/scientific societies

2012 – present President of the Israeli Forum for Cytoskeleton and Motility

2010 – 2012 The American Biophysical Society

2008 – present Israeli Society for Biophysics

2005 – present Israeli Society for Microscopy

2002, 2005 The American Biophysical Society

• Educational activities

Courses taught

2004-present Analytical Chemistry for Life Sciences and Geology Students – (total of ~ 300 students, coordinator)

2007-present Laboratory in General and Analytical Chemistry for Life Sciences and Geology

Students (coordinator)

2007-2014 Structure-function relationship in motor protein activity, for Graduate students (coordinator)

1999-2013 General and Clinical Biochemistry for Medical and Medical Laboratory Sciences Students - Part 1 (coordinator since 2007)

2005-2012 Organic Chemistry for Medical Students

2002-2010 General and Clinical Biochemistry for Biomedical Engineering Students (coordinator)


1999-2001 General and Organic Chemistry for Nursing, Emergency Medicine and Physical

Therapy Students

2004 Cell Biology for Chemistry Students

2004-2006 Chapters in Biophysical Chemistry for Chemistry Students

Current Research group

Dr. Maria Popov – Lab manager

Dr. Himanshu Pandey – Postdoctoral fellow

Dr. Sudhir Kumar Singh – Postdoctoral fellow

Ofer Shapira – Ph.D. student

Nurit Schkolnik – Ph.D. student

Alina Goldstein – Ph.D. student

Darya Goldman – M.Sc. student

Haim Judah – Undergraduate student

Past Postdoctoral Fellows

Limor Cohen, Vladimir Fridman, Adina Gerson, Natalia Movshovich, Irena Gertsberg

Past Graduated Students

Ph.D.

2011 - Vladimir Fridman

2010 - Natalia Movshovich

2009 - Adina Gerson

2009 - Rachel Avunie

M.Sc.

2016 – Keren Miron

2014 - Nurit Schkolnik

2014 - Alina Goldstein

2012 - Ofer Shapira

2012 - Mariya Podolskaya

2011 - Alexander Sorkin, MD

2010 - Yael Nissenkorn

2009 - Yulia Zalkin

2008 - Vladimir fridman

2006 - Nataia Movshovich

2006 - Adina Gerson

2005 - Ilit Leizerman

2005 - Rachel Avunie

2005 - Keren Moyal

2004 - Adelina Mermelstain

Basic Science thesis for MD Degree and Residency

2004 - Doron Schwartz, MD

2003 - Bertha Delgado, MD


Undergraduate projects

2014 - Nir Funt

2014 - Roe Ashkenazy

2013 - Or Ivgi

2012 - Hila Cohen

2012 - Moran Damaty

2011 - Maya Pollok

2008 - Yael Nissenkorn

2007 - Alina Greko

2007 - Orr Reaifman

2006 - Vladimir Fridman

2005 - Keren Moyal

2002 - Ilit Leizerman

• Awards, Citations, Honors, Fellowships

Honors, Citation Awards (including during studies)

1987 - Department of Chemistry, Ben-Gurion University, The Amnon Zingerman Award for Academic Achievements in B. Sc. studies

1989 - Department of Chemistry, Ben-Gurion University, The Avraham Haimovitch Award for Academic Achievements

1989 - Ben-Gurion University, the Rector's Award for Outstanding Excellence in M.Sc. Studies

1991 - The Israel Chemical Society, Award in the Memory of Ruth and Prof. Milton Orchin

1991 - Department of Chemistry, Ben-Gurion University, the Bet-Haemek Biological Industries Award for Excellence in Biophysics Studies

1992 - The Wolf Foundation Award for Excellence in Ph.D Studies

1993 - Department of Chemistry, Ben-Gurion University, Machteshim Industries Award in the Memory of Masha and Zvi Sharib, for excellence in Ph.D. research

Fellowships

1995 - The Rothschild Postdoctoral Fellowship (~$25,000)

1995 - The Fulbright Foundation Postdoctoral Fellowship (~$15,000)

• Scientific Publications

a) h-index: ISI - 16; google scholar - 19

b) total number of citations of all articles: ISI - 795

c) total number of citations without self-citations: ISI - 728

Chapter in book

L. Gheber and Z. Priel. (1998) Metachronal wave, ciliary stroke and mucus propulsion. In Mucus Cilia and Mucociliary Interactions, Marcel Dekker, Inc. Edited by G.L. Baum et al., pp. 103-118.


Publications Book chapter L. Gheber and Z. Priel. (1998) Metachronal wave, ciliary stroke and mucus propulsion. In

Mucus Cilia and Mucociliary Interactions, Marcel Dekker, Inc. Edited by G.L. Baum et al., pp. 103-118.

Refereed articles in scientific journals

O. Shapira, A. Goldstein, J. Al-Bassam, L. Gheber (2017) A potential physiological role for bi-directional motility and motor clustering of mitotic kinesin-5 Cin8 in yeast mitosis Journal of Cell Science 130(4): 725-734 Featured in an “In this issue” minireview. https://www.ncbi.nlm.nih.gov/pubmed/28069834

O. Shapira and L. Gheber (2016) Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain Scientific Reports 6:25597

https://www.ncbi.nlm.nih.gov/pubmed/27216310 H. Asraf, R. Avunie-Masala, M. Hershfinkel and L. Gheber (2015) Mitotic slippage and

expression of survivin are linked to differential sensitivity of human cancer cell-lines to the kinesin-5 inhibitor monastrol PLOS ONE 10(6):e0129255A. http://www.ncbi.nlm.nih.gov/pubmed/26035434

A. Düselder, V. Fridman, C. Thiede, A. Wiesbaum, A. Goldstein, D. R. Klopfenstein, O. Zaitseva, M. E. Janson, L. Gheber, and C.F. Schmidt (2015) Deletion of the Tail Domain of the Kinesin-5 Cin8 affects its directionality Journal of Biological Chemistry 290(27):16841-50. http://www.ncbi.nlm.nih.gov/pubmed/25991727

V. Fridman, A. Gerson-Gurwitz, O. Shapira, N. Movshovich, S. Lakämper, C.F. Schmidt, and L. Gheber (2013) Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. Journal of Cell Science 5;126(Pt 18):4147-59. Featured in “In this issue” minireview. http://www.ncbi.nlm.nih.gov/pubmed/23868978

C. Thiede, V. Fridman, A. Gerson-Gurwitz, L. Gheber and C. F. Schmidt (2012) Regulation of bi-directional movement of single kinesin-5 Cin8 molecules. Bio-Architecture 2, 70-74. Joint corresponding authorship. http://www.ncbi.nlm.nih.gov/pubmed/22754632

A. Gerson-Gurwitz, C. Thiede, N. Movshovich, V. Fridman, M. Podolskaya, T. Danieli, S. Lakämper, D.R. Klopfenstein, C.F. Schmidt and L. Gheber (2011) Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. EMBO Journal 18;30(24):4942-54. http://www.ncbi.nlm.nih.gov/pubmed/22101328

A. Sadeh, N. Movshovich, M. Volokh, L. Gheber and A. Aharoni (2011) Fine-Tuning of the Msn2/4-Mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners. Molecular Biology of the Cell 22(17):3127-38. http://www.ncbi.nlm.nih.gov/pubmed/21757539

R. Avunie-Masala, N. Movshovich, Y. Nissenkorn, A. Gerson-Gurwitz, V. Fridman, M. Kõivomägi, M. Loog, M.A. Hoyt, A. Zaritsky and L. Gheber. (2011) Phospho-regulation of Kinesin-5 function during anaphase spindle elongation. Journal of Cell Science 15;124(6):873-8. http://www.ncbi.nlm.nih.gov/pubmed/21378308

O. Voloshin, Y. Gocheva, M. Gutnick, N. Movshovich, A. Bakhrat, K. Baranes-Bachar, D. Bar-Zvi, R. Parvari, L. Gheber and D. Raveh. (2010) Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress.

https://www.ncbi.nlm.nih.gov/pubmed/28069834

https://www.ncbi.nlm.nih.gov/pubmed/27216310

http://www.ncbi.nlm.nih.gov/pubmed/26035434








Cellular and Molecular Life Sciences 67(12):2025-38. http://www.ncbi.nlm.nih.gov/pubmed/20204449

A. Avraham, J. Sandbank, N. Yarom, A. Shalom, T. Karni, I. Pappo, A. Sella, A. Fich, S. Walfisch, L. Gheber and E. Evron. (2010) A similar cell specific pattern of HoxA methylation in normal and in cancer tissues. Epigenetics 5(1):1-6. http://www.ncbi.nlm.nih.gov/pubmed/20083893

V. Fridman, A. Gerson-Gurwitz, N. Movshovich, M. Kupiec and L. Gheber. (2009) Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation. EMBO Reports 10(4):387-93. http://www.ncbi.nlm.nih.gov/pubmed/19270715

A. Gerson-Gurwitz, N. Movshovich, K. Moyal, R. Avunie-Masala, V. Fridman, MA. Hoyt, B. Katz and L. Gheber. (2009) Mid-anaphase arrest in cells eliminated for the function of Cin8 and dynein. Cellular and Molecular Life Sciences 66(2):301-13. http://www.ncbi.nlm.nih.gov/pubmed/19099194

N. Movshovich, V. Fridman, A. Gerson-Gurwitz, I. Schumacher, I. Gertsberg, A. Fich, MA. Hoyt, B. Katz and L. Gheber. (2008) Slk19-dependent mid-anaphase pause in kinesin-5 mutated cells. Journal of Cell Science 121:2529-39. http://www.ncbi.nlm.nih.gov/pubmed/18628309

N. Dubi, L. Gheber, D. Fishman, M Hershfinkel and I. Sekler. (2008) Extracellular Zinc and Zink-citrate acting through a putative Zinc sensing receptor, regulate growth and survival of prostate cancer cells. Carcinogenesis 29:1692-700. http://www.ncbi.nlm.nih.gov/pubmed/18310092

E.R. Hildebrandt, L. Gheber, T. Kingsbury and M.A. Hoyt (2006), Homotetrameric form of Cin8p, an S. cerevisiae kinesin-5 motor, is essential for its in vivo function. Journal of Biological Chemistry 281:26004-26013. http://www.ncbi.nlm.nih.gov/pubmed/16829678

A. Mermelshtein, A. Gerson, S. Walfisch, B. Delgado, G. Shechter-Maor, J. Delgado, A. Fich and L. Gheber. (2005) Expression of D-type cyclins in colon cancer and in cell-lines from colon carcinomas. British Journal of Cancer 93(3):338-45. http://www.ncbi.nlm.nih.gov/pubmed/16012517

A. Ben-Dor, M. Steiner, L. Gheber, M. Danilenko, N. Dubi, A. Zick, Y. Sharoni and J. Levy. (2005) Carotenoids activate the antioxidant response element (ARE) transcription system. Molecular Cancer Therapeutics 4(1):177-86. Featured on the cover. http://www.ncbi.nlm.nih.gov/pubmed/15657364

I. Leizerman, R. Avunie-Masala, M. Elkabets, A. Fich and L. Gheber (2004) Differential effect of monastrol in two human cell lines. Cellular and Molecular Life Sciences 61(16):2060-70. http://www.ncbi.nlm.nih.gov/pubmed/15316655

R. Peleg, I.Z. Ben-Zion, A. Peleg, L. Gheber, M. Kotler, Z. Weizman, A. Shiber, A. Fich, Y. Horowitz and P. Shvartzman (2004) Bread madness revisited; screening for specific celiac antibodies among schizophrenia patients. European Psychiatry 19(5):311-4. http://www.ncbi.nlm.nih.gov/pubmed/15276666

O. Zagoory, A. Braiman, L. Gheber and Z. Priel (2001) The role of calcium and calmodulin in ciliary stimulation induced by acetylcholine. American Journal of Physiology-Cell Physiology 280(1):100-9. http://www.ncbi.nlm.nih.gov/pubmed/11121381

F. R. Cottingham, L. Gheber, D. L. Miller and M. Andrew Hoyt (2000) Novel roles for saccharomyces cerevisiae mitotic spindle motors. The Journal of Cell Biology 147:335-349. Equal contribution; Featured on the cover and in an “In Brief” minireview. http://www.ncbi.nlm.nih.gov/pubmed/10525539















L. Gheber, S.C. Kuo and M.A. Hoyt. (1999) Motile properties of the kinesin-related Cin8p spindle motor extracted from S. cerevisiae cells. Journal of Biological Chemistry 274:9564-9572. http://www.ncbi.nlm.nih.gov/pubmed/10092642

L. Gheber, A. Korngreen and Z. Priel. (1998) Effect of viscosity on metachrony in mucus propelling cilia. Cell Motility and the Cytoskeleton 39:9-20. http://www.ncbi.nlm.nih.gov/pubmed/8531202

L. Gheber and Z. Priel. (1997) Extraction of cilium beat parameters by the combined application of photoelectric measurement and computer simulation. Biophysical Journal 72:449-462. http://www.ncbi.nlm.nih.gov/pubmed/8994632

A. Tarasiuk, M. Bar-Shimon, L. Gheber, A. Korngreen and Z. Priel. (1995) Extracellular ATP -induced hyperpolarization and motility stimulation of ciliary cells. Biophysical Journal 68:1163-1169. http://www.ncbi.nlm.nih.gov/pubmed/7756536

L. Gheber, Z. Priel, C. Aflalo and V. Shoshan-Barmatz. (1995) Extracellular ATP binding proteins as potential receptors in mucociliary epithelium: characterization using [32P]3'-O-(4-Benzoyl)benzoyl ATP, a photoaffinity label. Journal of Membrane Biology 147:83-93. http://www.ncbi.nlm.nih.gov/pubmed/8531202

L. Gheber and Z. Priel. (1994) Metachronal activity of cultured mucociliary epithelium under normal and stimulated conditions. Cell Motility and the Cytoskeleton 28:333-345. http://www.ncbi.nlm.nih.gov/pubmed/7954860

Z. Weiss, L. Gheber, V. Shoshan-Barmatz and Z. Priel. (1992) A possible mechanism of ciliary stimulation by extracellular ATP: Involvement of calcium dependent potassium channels and extracellular Ca2+. Journal of Membrane Biology 127:185-193. http://www.ncbi.nlm.nih.gov/pubmed/1495086

L. Gheber and Z. Priel. (1990) On metachronism in ciliary systems: a model describing the dependence of the metachronal wave properties on the intrinsic ciliary parameters. Cell Motility and the Cytoskeleton 16:167-181. http://www.ncbi.nlm.nih.gov/pubmed/2364445

L. Gheber and Z. Priel. (1990) Ciliary activity under normal conditions and under viscous load. Biorheology 27:547-557. http://www.ncbi.nlm.nih.gov/pubmed/2261520

L. Gheber and Z. Priel. (1989) Synchronization between beating cilia. Biophysical Journal 55:183-191. http://www.ncbi.nlm.nih.gov/pubmed/2930819

Unrefereed professional articles and publications

L. Gheber (2012) הנעה הפוכה Reverse propulsion. גלילאו Galileo (scientific journal for children and youth) 50:31-32

• Lectures and Presentations at Meetings and Invited Seminars

Invited lectures at conferences/meetings

1997, Metachronal wave, ciliary stroke and mucus propulsion. International Congress on Cilia, Mucus and Mucociliary Interactions, Jerusalem, Israel

2003, Regulation of a microtubule-based motor protein, The 3rd Bi-National France-Israel workshop on Biosensors, Biochips and Nanobiotechnology, Eilat, Israel

2005, Function and regulation of a mitotic kinesin-related motor protein, 49th Annual meeting of the Israeli Society for Microscopy, Beer-Sheva, Israel












2007, Kinesin-5 motors and mitotic spindle dynamics, The Membrane Trafficking Meeting

of the Israeli Society for Cell Biology, Hertzelia, Israel

2008, N. Movshovich, V. Fridman, A. Gerson-Gurwitz, M.A. Hoyt, L. Gheber, Kinesin-5 function and interpolar microtubule dynamics during anaphase spindle elongation, The 12th International Congress on Yeast, Kiyiv, Ukraine

2008, V. Fridman, N. Movshovich, A. Gerson-Gurwitz, B.Katz, M. A. Hoyt, L. Gheber., Interpolar microtubule dynamics and kinesin-5 activity during anaphase spindle elongation, UK and Israel Bi-Lateral Meeting on Genome Stability In Health and Disease, Jerusalem, Israel

2009, R. Avunie, E. Admon, V. Fridman, A. Fich, Mechanisms underlying the differential sensitivity of human cell-lines to monastrol, a prototype of new anti-cancer agents, Foshan, China

2009, Regulation of S. cerevisiae kinesin-5 Cin8 during mitosis, Genome Stability Meeting, BGU, Beer-Sheva, Israel

2011, Regulation of the Motor Functions of the S. cerevisiae Kinesin-5 proteins, Motility Subgroup, 55th Meeting of the Biophysical Society, Baltimore, USA

2011, Knesin-5 motor proteins and microtubule dynamics during mitosis in S. cerevisiae cells, 5th Meeting of the Israel Live Imaging Forum, Weizmann Institute, Israel

2012, Directionality and intracellular functions of mitotic Kinesin-5 nanomachines, Annual Meeting of the Israeli Society of Physiology and Pharmacology, Jerusalem, Israel

2012, Mitotic kinesin-5 motors – not unidirectional anymore, The 46th Annual Scientific Meeting of Israeli Society for Microscopy, Beer-Sheva, Israel

2013, Studying function and regulation of mitotic kinesin motors using live microscopy

and single-molecule fluorescence motility assay, Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel

2013, Directionality of kinesin nano-motors: old dogma new insights, The 3rd meeting of the Israeli Forum for Cytoskeleton and Motility (IFCM), Bar-Ilan University, Ramat-

Gan, Israel

2013, Regulation of Directionality and Function of Mitotic Kinesin-5 Motors, Microscopy at the Frontier of Science, Tarragona, Spain

2014, Kinesin-5 Nano Motors: Old Dogma New Insights, NanoIsrael, the 4thNanotachnology Conference, Tel-Avivi, Israel, March 2014

2014, How Do Mitotic Kinesin-5 Nano-motors Perform Their Intracellular Functions? BIT’s 4th Annual World Congress of Molecular and Cell Biology, Dalian, China

2014, Biological kinesin-5 nano-motors: Motile properties and intracellular functions, NanoTech 2014, San-Francisco, USA

Presentation of papers at conferences/meetings (oral)

L. Gheber and Z. Priel, A model describing the dependence of the metachronal wave parameters upon the intrinsic ciliary parameters, The 7th International Congress of Biorheology, Nancy, France, 1989

L. Gheber and Z. Priel , The relation between the time of delay and metachronal wavelength, 24th Annual Meeting of the SEPCR, Lausanne, Switzerland, 1989


I. Horshi, A. Fich and L. Gheber, Effect of monastrol, an inhibitor of a mitotic kinesin, on

cells from a gastric carcinoma cell line, The Half-Annual Meeting of the Israeli Society for Gastroenterology, Hertzlia, Israel, 2002

L. Gheber, A. Mermelshtein, G. Schechter, B. Delgado, J. Delgado, S. Walfisch and A. Fich Expression of D-type cyclins in malignant colorectal tissue, The Half Annual Meeting of the Israeli Society for Gastroenterology, Dead Sea, Israel, 2002

L. Gheber, Cin8p, a mitotic motor that drives mitosis, 2nd Joint Meeting of the Israeli Society of Cell Biology and Developmental Biology, Eilat, Israel, 2006

L. Gheber, Mitotic kinesin-related motor protein and neurite outgrowth. The Zlotowski center of neuroscience Annual Meeting, Israel, 2007

N. Movshovich, V. Fridman, R. Avunie, A. Gerson, I. Gertsberg, M. A. Hoyt, B. Katz, L. Gheber, Function and regulation of the S. cerevisiae Kinesin-5 mitotic motor Cin8,

Minerva - Weizmann Workshop, Moving Cell - from Molecules to Animals, Rehovot, Israel, 2007

L. Gheber, Kinesin-5 function during anaphase spindle elongation, The 5th Congress of the Federation of the Israel Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2008

V. Fridman, N. Movshovich, A. Gerson-Gurwitz, B.Katz, M. A. Hoyt, L. Gheber, Interpolar microtubule dynamics and kinesin-5 activity during anaphase spindle elongation, European Life Science Organization (ELSO) Meeting, Nice, France, 2008

L. Gheber, Function and Regulation of S. cerevisiae Kinesin-5 motor proteins during anaphase B spindle elongation, IDIBELL Cancer Conferences on the Cell Cycle, Barcelona, Spain, 2009

L. Gheber, Regulation of Kinesin-5 function during mitosis, ESF-EMBO Symposium on the

Emerging propertied of the Cytoskeleton: From Molecules to Cells, Sant Feliu de Guixols, Spain, 2010

L. Gheber, Regulation of Kinesin-5 motor function during mitosis, 6th Congress of the Federation of the Israeli Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2011

L. Gheber, Unique mitotic function of the kinesin-5 Kip1, Systems-Level View of Cytoskeletal Function, Stockholm, Sweden, 2014

L. Gheber, Regulation of the Bidirectional Motility of Biological Nanomotor Kinesin-5 Cin8, The 81 meeting of the Israeli Chemical Society, Tel-Aviv, Israel, 2016

L. Gheber, Regulation and possible physiological role for the bi-directional motility of S. cerevisiae kinesin-5 Cin8, Israeli Yeast Group Meeting, 2016

Seminar presentations at International universities and institutions

L. Gheber Kinesin-5 motor function and anaphase spindle elongation in S. cerevisiae cells, Department of Biology, The Johns Hopkins University, Baltimore, MD, USA, March 2009

L. Gheber Regulation of Kinesin-5 Function, 3rd Institute of Physics, George Augustus University of Gottingen, Gottingen, Germany, May 2009

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle Elongation, Institute of Biochemistry ETH, Zurich, Switzerland, October 2010


L. Gheber Regulation of the Motor Function of S. cerevisiae Kinesin-5 motors, Fred

Hutchinson Cancer Research Center, Seattle, WA, USA, March 2011

L. Gheber Control of the In Vivo and In Vitro Motor Functions of the S. cerevisiae Kinesin-5 Cin8, Mechanobiology Institute, Singapore, August 2011

L. Gheber To Switch or Not to Switch – Control of Directionality of a Mitotic Kinesin-5 Motor, Ludwig Cancer Research Institute, UC San-Diego, San-Diego, USA, February 2012

L. Gheber To Switch or Not to Switch – Control of Directionality of a Mitotic Kinesin-5 Motor, Department of Molecular and Cell Biology, UC Davis, Davis, USA, March 2012

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle Elongation, Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA,

USA, August 2013

L. Gheber Kinesin-5 Motors in Reverse Gear, Department of Molecular Oncology, European Institute of Oncology, Milan, Italy, February, 2013

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle Elongation, Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA, August 2013

L. Gheber, Functions and regulation of S. cerevisiae kinesin-5 motors, Department of Molecular and Cellular Biology, UC Davis, Davis, CA, USA, May 2015

L. Gheber, Moving in two directions: the unique functions of S. cerevisiae Kinesin-5 motors, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA, June 2015

L. Gheber, Moving in two directions: the unique functions of S. cerevisiae Kinesin-5

motors, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA, June 2015

Seminar presentations at Israeli universities and institutions

L. Gheber, Regulation of Kinesin-5 function during mitosis, Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel, 2009

L. Gheber, To switch or not to switch – control of directionality of mitotic Kinesin-5 motors. The Ilse Katz Institute of Nanoscale Science and Technology, BGU, Beer-Sheva, Israel, 2011

L. Gheber, To switch or not to switch – directionality control of a mitotic kinesin motor protein, Faculty of Biology, Israeli Institute of Technology, Haifa, Israel, April, 2012

L. Gheber, Regulation of Kinesin-5 motors, Department of Physiology, Tel-Aviv University, Tel-Aviv, Israel, March 2013

L. Gheber, Studying function and regulation of mitotic kinesin motors using live microscopy and single-molecule fluorescence motility assay, Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel, May, 2013

L. Gheber, Directionality of kinesin nano-motors: old dogma new insights, The National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel, May 2013

L. Gheber, Kinesin-5 Nano Motors: Old Dogma New Insights, Department of Biotechnology, Ben-Gurion University, Beer-Sheva, Israel, March 2014


L. Gheber, Kinesin-5 Nano Motors: Old Dogma New Insights, Department of Biology, Bar-

Ilan University, Ramat-Gan, Israel, April 2014

L. Gheber, Function and Regulation of Kinesin-5 Mitotic Nano-Motor, Department of Chemistry, The Hebrew University, Jerusalem, Israel, January 2015

L. Gheber, Regulation of the Bidirectional Motility of Biological Nanomotor Kinesin-5 Cin8, Department of Molecular Microsbiology and Biotachnology, Tel-Aviv University, Israel, May 2016

• Research Grants 1. 2000-2003, USA - Israel Binational Science Foundation. L. Gheber (PI), M.A. Hoyt (PI),

S.C. Kuo (PI), JHU Baltimore, USA. Subject: Regulation of Cin8p activity and its

multiple mitotic roles ($56,670 per year; $170,000 total)

2. 2000-2003, Israel Science Foundation. L. Gheber (PI). Subject: Activity and regulation of HsEg5, a human mitotic kinesin-related protein ($50,000 per year; $150,000 total)

3. 2001, Israel Science Foundation equipment grant for young researchers. L. Gheber (PI) ($178,000 total)

4. 2003, Israeli Health Office, the Chief Scientist grant. L. Gheber (PI). Subject: Expression and activity of D-type cyclins in normal and malignant colon tissue ($20,000 total)

5. 2004-2008, Israel Science Foundation. L. Gheber (PI) O. Almog (CI) Subject: Motor activity and structure of a bipolar kinesin ($30,000 per year; $120,000 total)

6. 2004-2008, USA - Israel Binational Science Foundation. L. Gheber (PI), M.A. Hoyt (PI),

JHU Baltimore, USA. Subject: Influencing microtubule dynamics: in vitro and in vivo study of S. cerevisiae mitotic motor proteins ($40,000 per year; $160,000 total)

7. 2009-2012, Lower Saxony (Germany) - Israel Research Grant. L. Gheber (PI), Prof C.F. Schmidt (PI) and S. Lakamper (PI), Institute of Physics, Gottingen University, Gottingen, Germany Subject: Regulation and structural basis of the cell-cycle dependent Cin8 motor activity ($90,000 per year; $270,000 total; $45,000 per year to BGU; $135,000 total to BGU)

8. 2009-1013, Israel Science Foundation. Subject: Microtubule dynamics and kinesin-5 function during normal and aberrant anaphase spindle elongation. L. Gheber (PI) ($40 per year; $160,000 total)

9. 2013-2018, Israeli Science Foundation. Subject: The switchable directionality of the mitotic kinesin-5 motors: structural determinants, regulation by phosphorylation, and

connection to intracellular functions. L. Gheber (PI) ($112,000 per year; $560,500 total) One of the largest grants awarded by ISF to a single PI

10. 2016-2020, BSF-NSF. Subject: Exploring kinesin-5 evolutionary adaptation for mitotic spindle dynamics. L. Gheber (PI) ($80000 per year; $320000 total)

• Additional Information Scholarships, grants and prizes awarded to research students


2010 Students’ travel award, ESF-EMBO Meeting Meeting, Emergent Properties of the

Cytoskeleton: Molecules to Cells, Sant Feliu de Guixols, Spain, 3 - 8 October 2010, awarded to Vladimir Fridman

2010 United States-Israel Binational Science Foundation (BSF) travel grant for young scientists (a travel grant to the USA), awarded to Adina Gerson

2009 Department of Chemistry award for excellence in research, awarded to Adina Gerson

2008 DAAD Short-term Fellowship awarded to Vladimir Fridman for Collaborative Research in the George Augustus University of Gottingen, Gottingen, Germany

2008-2010 Scholarship for Interdisciplinary M.Sc. studies awarded to Yael Nissenkorn by the Rector of BGU

2007-2011 The Negev Scholarship for Ph.D. studies awarded to Vladimir Fridman by the

Kreitman School of Advanced Graduate Studies, BGU 2006 Bernard Cwikel prize for excellence in research, Faculty of Health Sciences, BGU,

awarded to Vladimir Fridman 2005 Department of Chemistry award for excellence in research, awarded to Adina

Gerson

2004 Department of Chemistry award for excellence in research, awarded to Adina Gerson

2004 First prize for the best poster - The 38th Annual Meeting of the Israel Society for Microscopy, Israel, awarded to Adina Gerson

2013 Best poster award – The 5th Annual meeting of the Israel Biophysical Society, IBS 2013, Hebrew University, Jerusalem, Israel, awarded to Ofer Shapira

Selected Lectures and Posters Delivered by Group members and Students

R. Avunie, V. Fridman, B. Katz and L. Gheber. Sensitivity of human cancer cell lines to monatrol, a specific inhibitor of a mitotic kinesin-related protein. Joint Meeting of the Israeli Societies for Cell Biology and Developmental Biology, Eilat, Israel 2006

V. Fridman, I. Shumacher, N. Movshovich, B. Katz and L. Gheber, Spindle midzone

organization during mid-anaphase pause induced by mutations in kinesin-5 motor proteins. European Life Science Organization (ELSO) Annual Meeting, Dresden, Germany, September, 2007

V. Fridman, N. Movshovich and L. Gheber. In vivo and in vitro functions of the S. cerevisiae kinesin-5 Kip1. European Molecular Biology Organization (EMBO) Annual Meeting, Amsterdam, Netherland, 2009

V. Fridman, N. Movshovich, S. Lakamper, C.F. Schmidt, and L. Gheber, Anaphase midzone

organization and motile properties of the S, cerevisiae Kinesin-5 Kip1. ESF-EMBO Meeting, Emergent Properties of the Cytoskeleton: Molecules to Cells, Sant Feliu de Guixols, Spain, 2010

V. Fridman, N. Movshovich, L. Gheber. In vivo and in vitro function of the S. cerevisiae kinesin-5 Kip1. Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

M. Podolskaya, A. Gerson-Gurwitz, C. Thiede, N. Movshovits, V. Fridman, S. Lakaemper, C.F. Schmidt and L. Gheber. The effect of mitotic spindle-binding proteins on the in vivo and in vitro function of the kinesin-5 Cin8. 44th Meeting of the Israeli Society for Microscopy, Tev-Aviv, Israel, 2010


A. Gerson-Gurwitz, C. Thiede, N. Movshovits, M. Podolskaya, V. Fridman, S. Lakaemper,

C.F. Schmidt and L. Gheber. In vivo and in vitro functions of Cin8, the S. cerevisiae mitotic kinesin-5 motor protein. Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

N. Movshovich, A.Gerson-Gurwitz, R.Avunie, M.A. Hoyt, B. Katz and L. Gheber, Spindle localization of the S. cerevisiae kinesin-5 Cin8 during anaphase spindle elongation. Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

Y. Nissenkorn, A. Zaritsky, and L. Gheber. Phosphoregulation of Kinesin-5 Cin8 during Mitosis in S. cerevisiae. Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

M. Podolskaya, A. Gerson-Gurwitz, C. Thiede, N. Movshovits, V. Fridman, S. Lakaemper, C.F. Schmidt and L. Gheber, The effect of mitotic spindle-binding proteins on the in vivo and in vitro function of the kinesin-5 Cin8. 6th Congress of the Federation of the

Israeli Societies for Experimental Biology FISEB (ILANIT). Eilat, Israel, 2011

A. Sorkin, V. Fridman, and L. Gheber, Influence of motor proteins on microtubule dynamics during late anaphase in S. cerevisiae cells. 6th Congress of the Federation of the Israeli Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2011

V. Fridman, A, Gerson-Gurwitz, C. Thiede , N. Movshovich, M. Podolskaya, S. Lakamper, C.F. Schmidt and L. Gheber. Mitotic functions and motile properties of the S. cerevisiae Kinesin-5 motors. 55th Meeting of the Biophysical Society, Baltimore, USA, 2011 (oral presentation)

O. Shapira, A. Gerson-Gurwitz, M. Podolskaya and L. Gheber, Effect of phosphorylation on the motility of the biological nano motor Cin8. The 46th Annual Meeting of the Israeli Society for Microscopy (ISM), Ben-Gurion University of the Negev, Beer-Sheva, Israel, May 2012

O. Shapira, A. Gerson-Gurwitz, M. Podolskaya and L. Gheber. Effect of phosphorylation on the motility of the biological nano motor Cin8. Nano Israel 2012, Tel Aviv, Israel, March 2012

O. Shapira, A. Gerson-Gurwitz and L. Gheber, Effect of phosphorylation on the motility of the biological nano motor Cin8. Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May, 2013

A. Goldstein, L. Holt and L. Gheber, Evolution of phospho-regulation of mitotic kinesin-5 motor protein. Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May 2013

N. Schkolnik and L. Gheber, Regulation of motor protein Cin8 by phosphorylation. Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May 2013

O. Shapira and L. Gheber, Phospho-regulation of kinesin-5 movement. The Annual Meeting of the Israeli Live Imaging Forum on Super-Resolution and Advanced Imaging, Ben-Gurion University, Beer-Sheva, Israel, June 25, 2013 (oral presentation)

O. Shapira, A Gerson-Gurwitz and L. Gheber, Effect of phosphorylation on the motility of the biological nano motor Cin8. 9th European Biophysics Congress, EBSA2013, Lisbon, Spain July, 2013


O. Shapira and L. Gheber. Regulation of the in vitro motile properties of mitotic kinesin,

The 5th Annual meeting of the Israel Biophysical Society, IBS 2013, Hebrew University, Jerusalem, Israel, September, 2013 (Best poster award)

O. Shapira and L. Gheber. Motile properties of a mitotic kinesin are regulated by phosphorylation, The 7th FISEB ILANIT Congress 2014, Eilat, Israel, February, 2014

A. Goldstein, L. Holt and L. Gheber. Targeted-evolution approach to elucidate the plasticity of a mitotic kinesin phospho-regulation by Cdk1. The 7th FISEB ILANIT Congress. Eilat, Israel. February 10-13, 2014.

N. Siegler and L. Gheber. Mechanism of phospho-regulation of mitotic kinesin-5, 7th FISEB (ILANIT) Congress, Eilat, Israel, February 2014

A. Goldstein, L. Holt and L. Gheber. Phospho-regulation plasticity of a mitotic kinesin Cin8, probed by generation of novel Cdk1 sites. NanoIsrael 2014. David Hotel, Tel-

Aviv, Israel, March 24-25, 2014.

N. Siegler and L. Gheber. Phosphorylation as regulatory mechanism of the mitotic motor protein Cin8, 4th International Nanotechnology Conference, Tel Aviv, Israel, March 2014

O. Shapira and L. Gheber. Regulation of the in vitro motile properties of biological nano-motor, Nano Israel 2014 Conference, Tel-Aviv, Israel, March, 2014

O. Shapira and L. Gheber. Regulation of the in vitro motile properties of biological nano-motor, Ilse Katz Institute Day 2014, Ben-Gurion University, Beer-Sheva, Israel, May, 2014

A. Goldstein, L. Holt and L. Gheber. Phospho-regulation plasticity of a mitotic nano-motor Cin8, probed by generation of novel Cdk1. Ilse Katz Institute Day 2014. Ben-Gurion University, Beer-Sheva, Israel, May 29, 2014.

N. Siegler and L. Gheber. Phosphorylation as regulatory mechanism of the mitotic motor protein Cin8, Ilse Katz Institute Nanotechnology Day, Ben-Gurion University, Beer-Sheva, Israel, May 2014

A. Goldstein, L. Holt and L. Gheber. Phospho-regulation of a mitotic motor protein

investigated by targeted evolution approach. The Israel Society for Molecular Biology & Biochemistry 2014 Annual Meeting ISBMS. Weizmann Institute of Science, Rehovot Israel, December 4, 2014.

O. Shapira and L. Gheber. Phosphorylation regulates the motile properties of a kinesin-5 molecular motor, 2014 Annual Meeting of the Israel Society for Biochemistry & Molecular Biology, ISBMB 2014, Weizmann Institute of Science, Rehovot, Israel, December, 2014

O. Shapira and L. Gheber. Phosphorylation regulates the motile properties of a mitotic kinesin Biophysical Society 59th Annual Meeting, BPS 2015, Baltimore, Maryland, USA, February, 2015

A. Goldstein, N. Siegler, L. Holt and L. Gheber. Study of phospho-regulation of a mitotic kinesin using a directed evolution approach. The Biophysical society 59th Annual Meeting. Baltimore Maryland, Conference Center, USA, February 7-11, 2015.

A. Goldstein, L. Holt and L. Gheber. Study of phospho-regulation of a mitotic kinesin using a directed evolution approach. International Symposium Frontiers in Chemical Sciences 2015. Weizmann Institute of Science, Rehovot Israel, May 26, 2015.


K. Miron, O. Shapira and L. Gheber. Factors that affect the in vitro motility of kinesin-5

Cin8 on microtubules, Frontiers in Super Resolution Microscopy: bio-imaging and beyond, Ben Gurion University, Midreshet Sde Boker, Israel May, 2015

D. Goldman and L. Gheber. Spindle and cell-shape morphology in cells expressing Cdk1 Cin8 mutants, Frontiers in Super Resolution Microscopy: bio-imaging and beyond, Ben Gurion University, Midreshet Sde Boker, Israel May, 2015

O. Shapira Regulation and a possible physiological role for the bi-directional motility of the biological Kinesin-5 motor protein, Cin8. The Golden Jubilee Annual Meeting of the Israel Society for Microscopy 2016; May 31st – June 2nd; Haifa, Israel;

O. Shapira Regulation of the directionality of S. cerevisiae Kinesin-5, Cin8 and a possible role of its minus-end motility. The 4th Annual Meeting of the Israeli Forum for Cytoskeleton and Motility; January 14th 2016; Haifa, Israel;