Leah (Larisa) Gheber January, 2014 CURRICULUM …in.bgu.ac.il/en/natural_science/chem/lgheber/Documents/...2012 - Hila Cohen 2012 - Moran Damaty 2011 - Maya Pollok 2008 - Yael Nissenkorn

Leah (Larisa) Gheber January, 2014

CURRICULUM VITAE AND LIST OF PUBLICATIONS

• Personal Details

Name: Leah (Larisa) Gheber

Marital Status: Married, three children

Date and place of birth: January 18, 1964, Ukraine

Date of immigration: August, 1974

Regular military service: 1982-1984

Address and telephone number at work:

Department of Chemistry, the Marcus Campus, 62/119, Beer-Sheva, 84105, Israel

+972-8-6461183

Address and telephone number at home: Haruv 7 Omer, 84965, Israel

+972-8-6437583

• Education

B.Sc. 1984-1987 Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Chemistry, Cum Laude

M.Sc. 1987-1990 Biophysical Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Summa Cum Laude. Adviser: Prof. Zvi Priel. Title of thesis: The properties of the metachronal wave

Ph.D. 1990-1995 Ben-Gurion University of the Negev, Beer-Sheva, Israel. Biophysical

Chemistry. Adviser: Prof. Zvi Priel. Thesis title: Full characterization

of mucociliary activity in vitro

Post doctorate 1995 – 1999 Department of Biology, The Johns Hopkins University, Baltimore, Maryland, USA. Under the supervision of Prof. M. Andrew Hoyt

• Employment History (in reverse chronological order, including sabbatical leave)

2012 - present Senior Lecturer, Departments of Chemistry, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

2010 - 1012 Senior Lecturer, Departments of Clinical Biochemistry and

Chemistry, Faculties of Health and Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

2005 - 2010 Lecturer, Departments of Clinical Biochemistry and Chemistry, Faculties of Health and Natural Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

1999 - 2005 Lecturer and Gastroenterology Laboratory Director, Departments of Clinical Biochemistry and Gastroenterology, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka University Medical Center, Beer-Sheva, Israel.

1995 - 1999 Postdoctoral fellow, Department of Biology, Johns Hopkins

University, Baltimore, Maryland, USA.

Leah (Larisa) Gheber page 2 January 2014

1986 - 1995 Instructor and Research Assistant, Department of Chemistry, Ben-

Gurion University of the Negev, Beer-Sheva, Israel.

• Professional Activities

Positions in academic administration (departmental, faculty and university)

2012 – present Member of the University Centers Committee, BGU

2012 – present Head of the Undergraduate Teaching Committee, Department of

Chemistry, BGU

2012 –2013 Biophysical and Organic Chemistry Seminar Coordinator, Department of Chemistry, BGU

2011 – 2012 Teaching Committee, M.Sc. Students, Basic Science Division, Faculty of

Health Sciences, BGU

2011 – 2012 Seminar Coordinator, Ilse Katz Institute for Nanoscale Science and

Technology, BGU

2010 – 1011 Seminar Coordinator, Clinical Biochemistry Department, Faculty of Health

Sciences, Ben-Gurion University of the Negev, BGU

2008 – 2011 Coordinator of the Biophysical Chemistry Track, Department of Chemistry, Faculty of Natural Sciences, BGU

2008 – present Teaching Committee, M.Sc. Students, Chemistry Department, Faculty of

Natural Sciences, BGU

2003 – 2006 Seminar Coordinator, Clinical Biochemistry Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, BGU

2003 – present Teaching Committee, School of Medical Laboratory Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, BGU

2006 – 2011 Committee on Admission for the Prospective Medicine Students, Faculty of

Health sciences, BGU

Professional functions outside universities/institutions

2013 Session Chair, Microscopy at the Frontier of Science, Tarragona, Spain, September

2013

2013 Session Chair, Batsheva de Rothschild Seminar on Soft Matter and Biophysics, Ben Gurion University and the Dead Sea 10-14, February 2013

2013 Organizing Committee, The Annual Meeting of the Israeli Live Imaging Forum on Super-Resolution and Advanced Imaging, June 25, 2013

2012 Organizing Committee, 46th Annual meeting of the Israeli Society for Microscopy,

Beer-Sheva, Israel

2012 – present Board member of the Israeli Society of Biophysics

2012 – present Initiator and Steering Committee Member of the Israeli Forum for Cellular and Cytoskeleton Motility (IFCCM)

2003-2013 Review of five manuscripts, two for Journal of Biological Chemistry; one for

Food and Chemical Toxicology; one for Life Sciences and one for Biophysical Journal

2003 – 2013 Review of several grant proposals for ISF, GIF, BSF, Israeli Ministry of Health and the Israeli Cancer association


2008 Session Chair, Intracellular Motility and Cell Division, The 5th Congress of the

Federation of the Israel Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2008

2005 Organizing Committee, 39th Annual meeting of the Israeli Society for Microscopy, Beer-Sheva, Israel

Membership in professional/scientific societies

2012 – present The Israeli Forum for Cytoskeleton and Motility

2010 – 2012 The American Biophysical Society

2008 – present Israeli Society for Biophysics

2005 – present Israeli Society for Microscopy

2002, 2005 The American Biophysical Society

• Educational activities

Courses taught

1999-present General and Clinical Biochemistry for Medical and Medical Laboratory Sciences

Students - Part 1 (coordinator since 2007)

2005-2012 Organic Chemistry for Medical Students

2002-2010 General and Clinical Biochemistry for Biomedical Engineering Students (coordinator)

2004-present Analytical Chemistry for Life Sciences and Geology Students – (total of ~ 300

students, coordinator)

1999-2001 General and Organic Chemistry for Nursing, Emergency Medicine and Physical

Therapy Students

2004 Cell Biology for Chemistry Students

2004-2006 Chapters in Biophysical Chemistry for Chemistry Students

2007-present Structure-function relationship in motor protein activity, for Graduate students (coordinator)

Research students

Current Research group

Ofer Shapira – Ph.D.

Nurit Schkolnik – M.Sc.

Alina Goldstein – M.Sc.

Darya Goldman – M.Sc.

Nir Funt – B.Sc. project

Roey Ashkenazi – B.Sc. project

Past Postdoctoral Fellows

Vladimir Fridman

Adina Gerson

Natalia Movshovich

Irena Gertsberg


Graduated Research students

Ph.D.

2011 - Vladimir Fridman

2010 - Natalia Movshovich

2009 - Adina Gerson

2009 - Rachel Avunie

M.Sc.

2012 - Ofer Shapira

2012 - Mariya Podolskaya

2011 - Alexander Sorkin, MD

2010 - Yael Nissenkorn

2009 - Yulia Zalkin

2008 - Vladimir fridman

2006 - Nataia Movshovich

2006 - Adina Gerson

2005 - Ilit Leizerman

2005 - Rachel Avunie

2005 - Keren Moyal

2004 - Adelina Mermelstain

Basic Science thesis for MD Degree and Residency

2004 - Doron Schwartz, MD

2003 - Bertha Delgado, MD

Undergraduate projects

2013 - Or Ivgi

2012 - Hila Cohen

2012 - Moran Damaty

2011 - Maya Pollok

2008 - Yael Nissenkorn

2007 - Alina Greko

2007 - Orr Reaifman

2006 - Vladimir Fridman

2005 - Keren Moyal

2002 - Ilit Leizerman

• Awards, Citations, Honors, Fellowships

Honors, Citation Awards (including during studies)

1987 - Department of Chemistry, Ben-Gurion University, The Amnon Zingerman Award

for Academic Achievements in B. Sc. studies

1989 - Department of Chemistry, Ben-Gurion University, The Avraham Haimovitch Award for Academic Achievements

1989 - Ben-Gurion University, the Rector's Award for Outstanding Excellence in M.Sc. Studies

1991 - The Israel Chemical Society, Award in the Memory of Ruth and Prof. Milton Orchin


1991 - Department of Chemistry, Ben-Gurion University, the Bet-Haemek Biological

Industries Award for Excellence in Biophysics Studies

1992 - The Wolf Foundation Award for Excellence in Ph.D Studies

1993 - Department of Chemistry, Ben-Gurion University, Machteshim Industries Award in the Memory of Masha and Zvi Sharib, for excellence in Ph.D. research

Fellowships

1995 - The Rothschild Postdoctoral Fellowship (~$25,000)

1995 - The Fulbright Foundation Postdoctoral Fellowship (~$15,000)

• Scientific Publications

Chapter in book

L. Gheber and Z. Priel. (1998) Metachronal wave, ciliary stroke and mucus propulsion. In

Mucus Cilia and Mucociliary Interactions, Marcel Dekker, Inc. Edited by G.L. Baum et al., pp. 103-118.

Refereed articles in scientific journals

1. L. Gheber and Z. Priel. (1989) Synchronization between beating cilia. Biophysical

Journal 55:183-191.

2. L. Gheber and Z. Priel. (1990) Ciliary activity under normal conditions and under viscous load. Biorheology 27:547-557.

3. L. Gheber and Z. Priel. (1990) On metachronism in ciliary systems: a model describing the dependence of the metachronal wave properties on the intrinsic ciliary parameters. Cell Motility and the Cytoskeleton 16:167-181.

4. Z. Weiss, L. Gheber, V. Shoshan-Barmatz and Z. Priel. (1992) A possible mechanism

of ciliary stimulation by extracellular ATP: Involvement of calcium dependent

potassium channels and extracellular Ca2+. Journal of Membrane Biology 127:185-193.

5. L. Gheber and Z. Priel. (1994) Metachronal activity of cultured mucociliary epithelium under normal and stimulated conditions. Cell Motility and the Cytoskeleton 28:333-345.

6. L. Gheber, Z. Priel, C. Aflalo and V. Shoshan-Barmatz. (1995) Extracellular ATP

binding proteins as potential receptors in mucociliary epithelium: characterization

using [32P]3'-O-(4-Benzoyl)benzoyl ATP, a photoaffinity label. Journal of Membrane Biology 147:83-93.

7. A. Tarasiuk, M. Bar-Shimon, L. Gheber, A. Korngreen and Z. Priel. (1995) Extracellular ATP -induced hyperpolarization and motility stimulation of ciliary cells. Biophysical Journal 68:1163-1169.

8. L. Gheber and Z. Priel. (1997) Extraction of cilium beat parameters by the combined application of photoelectric measurement and computer simulation. Biophysical Journal 72:449-462.


9. L. Gheber, A. Korngreen and Z. Priel. (1998) Effect of viscosity on metachrony in

mucus propelling cilia. Cell Motility and the Cytoskeleton 39:9-20.

10. L. Gheber, S.C. Kuo and M.A. Hoyt. (1999) Motile properties of the kinesin-related Cin8p spindle motor extracted from S. cerevisiae cells. Journal of Biological Chemistry 274:9564-9572.

11. F. R. Cottingham, L. Gheber, D. L. Miller and M. Andrew Hoyt (2000) Novel roles

for saccharomyces cerevisiae mitotic spindle motors. The Journal of Cell Biology

147:335-349. Equal contribution; Featured on the cover and in an “In Brief” minireview.

12. O. Zagoory, A. Braiman, L. Gheber and Z. Priel (2001) The role of calcium and

calmodulin in ciliary stimulation induced by acetylcholine. American Journal of Physiology-Cell Physiology 280(1):100-9.

13. R. Peleg, I.Z. Ben-Zion, A. Peleg, L. Gheber, M. Kotler, Z. Weizman, A. Shiber, A. Fich, Y. Horowitz and P. Shvartzman (2004) Bread madness revisited; screening for specific celiac antibodies among schizophrenia patients. European Psychiatry 19(5):311-4.

14. I. Leizerman, R. Avunie-Masala, M. Elkabets, A. Fich and L. Gheber (2004) Differential effect of monastrol in two human cell lines. Cellular and Molecular Life Sciences 61(16):2060-70.

15. A. Ben-Dor, M. Steiner, L. Gheber, M. Danilenko, N. Dubi, A. Zick, Y. Sharoni and J.

Levy. (2005) Carotenoids activate the antioxidant response element (ARE) transcription system. Molecular Cancer Therapeutics 4(1):177-86. Featured on the cover.

16. A. Mermelshtein, A. Gerson, S. Walfisch, B. Delgado, G. Shechter-Maor, J. Delgado,

A. Fich and L. Gheber. (2005) Expression of D-type cyclins in colon cancer and in cell-lines from colon carcinomas. British Journal of Cancer 93(3):338-45.

17. E.R. Hildebrandt, L. Gheber, T. Kingsbury and M.A. Hoyt (2006), Homotetrameric form of Cin8p, an S. cerevisiae kinesin-5 motor, is essential for its in vivo function. Journal of Biological Chemistry 281:26004-26013.

18. N. Dubi, L. Gheber, D. Fishman, M Hershfinkel and I. Sekler. (2008) Extracellular Zinc

and Zink-citrate acting through a putative Zinc sensing receptor, regulate growth and survival of prostate cancer cells. Carcinogenesis 29:1692-700.

19. N. Movshovich, V. Fridman, A. Gerson-Gurwitz, I. Schumacher, I. Gertsberg, A. Fich, MA. Hoyt, B. Katz and L. Gheber. (2008) Slk19-dependent mid-anaphase pause in kinesin-5 mutated cells. Journal of Cell Science 121:2529-39.

20. A. Gerson-Gurwitz, N. Movshovich, K. Moyal, R. Avunie-Masala, V. Fridman, MA. Hoyt, B. Katz and L. Gheber. (2009) Mid-anaphase arrest in cells eliminated for the function of Cin8 and dynein. Cellular and Molecular Life Sciences 66(2):301-13.

21. V. Fridman, A. Gerson-Gurwitz, N. Movshovich, M. Kupiec and L. Gheber. (2009)

Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation. EMBO Reports 10(4):387-93.

22. A. Avraham, J. Sandbank, N. Yarom, A. Shalom, T. Karni, I. Pappo, A. Sella, A. Fich, S. Walfisch, L. Gheber and E. Evron. (2010) A similar cell specific pattern of HoxA methylation in normal and in cancer tissues. Epigenetics 5(1):1-6.


23. O. Voloshin, Y. Gocheva, M. Gutnick, N. Movshovich, A. Bakhrat, K. Baranes-Bachar,

D. Bar-Zvi, R. Parvari, L. Gheber and D. Raveh. (2010) Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress. Cellular and Molecular Life Sciences 67(12):2025-38.

24. R. Avunie-Masala, N. Movshovich, Y. Nissenkorn, A. Gerson-Gurwitz, V. Fridman, M. Kõivomägi, M. Loog, M.A. Hoyt, A. Zaritsky and L. Gheber. (2011) Phospho-regulation of Kinesin-5 function during anaphase spindle elongation. Journal of Cell Science 15;124(6):873-8.

25. A. Sadeh, N. Movshovich, M. Volokh, L. Gheber and A. Aharoni (2011) Fine-Tuning of the Msn2/4-Mediated yeast stress responses as revealed by systematic deletion of Msn2/4 partners. Molecular Biology of the Cell 22(17):3127-38.

26. A. Gerson-Gurwitz, C. Thiede, N. Movshovich, V. Fridman, M. Podolskaya, T. Danieli,

S. Lakämper, D.R. Klopfenstein, C.F. Schmidt and L. Gheber (2011) Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. EMBO Journal 18;30(24):4942-54.

27. C. Thiede, V. Fridman, A. Gerson-Gurwitz, L. Gheber and C. F. Schmidt (2012)

Regulation of bi-directional movement of single kinesin-5 Cin8 molecules. Bio-

Architecture 2, 70-74. Joint corresponding authorship.

28. V. Fridman, A. Gerson-Gurwitz, O. Shapira, N. Movshovich, S. Lakämper, C.F. Schmidt, and L. Gheber (2013) Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. Journal of Cell Science 126(18):4147-59. Featured in an “In Brief” minireview.

Unrefereed professional articles and publications

L. Gheber (2012) הנעה הפוכה Reverse propulsion. גלילאו Galileo (scientific journal for children and youth) 50:31-32

• Lectures and Presentations at Meetings and Invited Seminars not Followed by

Published Proceedings

Invited plenary lectures at conferences/meetings

L. Gheber, Metachronal wave, ciliary stroke and mucus propulsion International Congress on Cilia, Mucus and Mucociliary Interactions. In honor of the late Prof. Alex Silberberg. February 1997, Jerusalem, Israel, 1997

L. Gheber, Regulation of a microtubule-based motor protein. The 3rd Bi-National France-

Israel workshop on Biosensors, Biochips and Nanobiotechnology, Eilat, Israel, 2003

L. Gheber, Function and regulation of a mitotic kinesin-related motor protein. 49th

Annual meeting of the Israeli Society for Microscopy, Beer-Sheva, Israel, 2005

L. Gheber, Kinesin-5 motors and mitotic spindle dynamics. The Membrane Trafficking Meeting of the Israeli Society for Cell Biology, Hetzelia, Israel, 2007 (oral)

N. Movshovich, V. Fridman, A. Gerson-Gurwitz, M.A. Hoyt, L. Gheber, Kinesin-5 function and interpolar microtubule dynamics during anaphase spindle elongation, The 12th International Congress on Yeast, Kiyiv, Ukraine, 2008


V. Fridman, N. Movshovich, A. Gerson-Gurwitz, B.Katz, M. A. Hoyt, L. Gheber., Interpolar

microtubule dynamics and kinesin-5 activity during anaphase spindle elongation, UK and Israel Bi-Lateral Meeting on Genome Stability In Health and Disease, Jerusalem, Israel, 2008

L. Gheber, R. Avunie, E. Admon, V. Fridman, A. Fich, Mechanisms underlying the differential sensitivity of human cell-lines to monastrol, a prototype of new anti-cancer agents, Foshan, China, 2009

L. Gheber, Regulation of S. cerevisiae kinesin-5 Cin8 during mitosis, Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2009

L. Gheber, Regulation of the Motor Functions of the S. cerevisiae Kinesin-5 proteins,

Motility Subgroup, 55th Meeting of the Biophysical Society, Baltimore, USA, 2011

L. Gheber, Knesin-5 motor proteins and microtubule dynamics during mitosis in S.

cerevisiae cells, 5th Meeting of the Israel Live Imaging Forum, Weizmann Institute, Israel, 2011

L. Gheber, Directionality and intracellular functions of mitotic Kinesin-5 nanomachines. Annual Meeting of the Israeli Society of Physiology and Pharmacology, Jerusalem, Israel, January, 2012

L. Gheber, Mitotic kinesin-5 motors – not unidirectional anymore. The 46th Annual

Scientific Meeting of Israeli Society for Microscopy, Beer-Sheva, Israel, May 2012

L. Gheber, Studying function and regulation of mitotic kinesin motors using live microscopy and single-molecule fluorescence motility assay, Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May, 2013

L. Gheber, Directionality of kinesin nano-motors: old dogma new insights, The 3rd meeting

of the Israeli Forum for Cytoskeleton and Motility (IFCM), Bar-Ilan University, Ramat-Gan, Israel, July 2013

L. Gheber, Regulation of Directionality and Function of Mitotic Kinesin-5 Motors,

Microscopy at the Frontier of Science, Tarragona, Spain, September 2013

Lectures of papers at conferences/meetings (oral)

L. Gheber and Z. Priel, A model describing the dependence of the metachronal wave

parameters upon the intrinsic ciliary parameters. The 7th International Congress of Biorheology, Nancy, France, 1989

L. Gheber and Z. Priel , The relation between the time of delay and metachronal wavelength. 24th Annual Meeting of the SEPCR, Lausanne, Switzerland, 1989

I. Horshi, A. Fich and L. Gheber, Effect of monastrol, an inhibitor of a mitotic kinesin, on cells from a gastric carcinoma cell line. The Half-Annual Meeting of the Israeli Society for Gastroenterology, Hertzlia, Israel, 2002

L. Gheber, A. Mermelshtein, G. Schechter, B. Delgado, J. Delgado, S. Walfisch and A. Fich

Expression of D-type cyclins in malignant colorectal tissue. The Half Annual Meeting of the Israeli Society for Gastroenterology, Dead Sea, Israel, 2002

L. Gheber, Cin8p, a mitotic motor that drives mitosis. 2nd Joint Meeting of the Israeli Society of Cell Biology and Developmental Biology, Eilat, Israel, 2006

L. Gheber, Mitotic kinesin-related motor protein and neurite outgrowth. The Zlotowski center of neuroscience Annual Meeting, Israel, 2007


N. Movshovich, V. Fridman, R. Avunie, A. Gerson, I. Gertsberg, M. A. Hoyt, B. Katz, L.

Gheber, Function and regulation of the S. cerevisiae Kinesin-5 mitotic motor Cin8, Minerva - Weizmann Workshop, Moving Cell - from Molecules to Animals, Rehovot, Israel, 2007

L. Gheber, Kinesin-5 function during anaphase spindle elongation, The 5th Congress of the Federation of the Israel Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2008

V. Fridman, N. Movshovich, A. Gerson-Gurwitz, B.Katz, M. A. Hoyt, L. Gheber, Interpolar microtubule dynamics and kinesin-5 activity during anaphase spindle elongation, European Life Science Organization (ELSO) Meeting, Nice, France, 2008

L. Gheber, Function and Regulation of S. cerevisiae Kinesin-5 motor proteins during

anaphase B spindle elongation, IDIBELL Cancer Conferences on the Cell Cycle,

Barcelona, Spain, 2009

L. Gheber, Regulation of Kinesin-5 function during mitosis, ESF-EMBO Symposium on the Emerging propertied of the Cytoskeleton: From Molecules to Cells, Sant Feliu de Guixols, Spain, 2010

L. Gheber, Regulation of Kinesin-5 motor function during mitosis, 6th Congress of the Federation of the Israeli Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2011

Presentations at informal international seminars and workshops

L. Gheber Kinesin-5 motor function and anaphase spindle elongation in S. cerevisiae cells, Department of Biology, The Johns Hopkins University, Baltimore, MD, USA, March 2009

L. Gheber Regulation of Kinesin-5 Function, 3rd Institute of Physics, George Augustus

University of Gottingen, Gottingen, Germany, May 2009

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle Elongation, Institute of Biochemistry ETH, Zurich, Switzerland, October 2010

L. Gheber Regulation of the Motor Function of S. cerevisiae Kinesin-5 motors, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, March 2011

L. Gheber Control of the In Vivo and In Vitro Motor Functions of the S. cerevisiae Kinesin-

5 Cin8, Mechanobiology Institute, Singapore, August 2011

L. Gheber To Switch or Not to Switch – Control of Directionality of a Mitotic Kinesin-5 Motor, Ludwig Cancer Research Institute, UC San-Diego, San-Diego, USA, February 2012

L. Gheber To Switch or Not to Switch – Control of Directionality of a Mitotic Kinesin-5 Motor, Molecular and Cell Biology, UC Davis, Davis, USA, March 2012

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle

Elongation, Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA, August 2013

L. Gheber Kinesin-5 Motors in Reverse Gear, Department of Molecular Oncology, European Institute of Oncology, Milan, Italy, February, 2013

L. Gheber Function and Regulation of Kinesin-5 Proteins during Anaphase Spindle Elongation, Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA, August 2013


Seminar presentations at universities and institutions

L. Gheber, Regulation of Kinesin-5 function during mitosis, Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel, 2009

L. Gheber, To switch or not to switch – control of directionality of mitotic Kinesin-5

motors. The Ilse Katz Institute of Nanoscale Science and Technology, BGU, Beer-Sheva, Israel, 2011

L. Gheber, To switch or not to switch – directionality control of a mitotic kinesin motor protein, Faculty of Biology, Israeli Institute of Technology, Haifa, Israel, April, 2012

L. Gheber, Regulation of Kinesin-5 motors, Department of Physiology, Tel-Aviv University, Tel-Aviv, Israel, March 2013

L. Gheber, Studying function and regulation of mitotic kinesin motors using live

microscopy and single-molecule fluorescence motility assay, Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel, May, 2013

L. Gheber, Directionality of kinesin nano-motors: old dogma new insights, The National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev,

Beer-Sheva, Israel, May 2013

• Research Grants

1. 2000-2003, USA - Israel Binational Science Foundation. With M.A. Hoyt, S.C. Kuo, JHU Baltimore, USA. Subject: Regulation of Cin8p activity and its multiple mitotic roles ($170,000).

2. 2000-2003, The Israel Science Foundation. Subject: Activity and regulation of HsEg5,

a human mitotic kinesin-related protein ($150,000).

3. 2001, The Israel Science Foundation equipment grant for young researchers ($178,000).

4. 2003, The Israeli Health Office, the Chief Scientist grant. Subject: Expression and activity of D-type cyclins in normal and malignant colon tissue ($20,000).

5. 2006, Zlotowski Center Equipment Grant ($15,000) 6. 2004-2008, The Israel Science Foundation. Subject: Motor activity and structure of a

bipolar kinesin ($120,000). 7. 2004-2008, USA - Israel Binational Science Foundation. With M.A. Hoyt, JHU

Baltimore, USA. Subject: Influencing microtubule dynamics: in vitro and in vivo study of S. cerevisiae mitotic motor proteins ($160,000).

8. 2009-2012, Lower Saxony – Israel Research Grant. With Prof C.F. Schmidt and S.

Lakamper, Institute of Physics, Gottingen University, Gottingen, Germany Subject: Regulation and structural basis of the cell-cycle dependent Cin8 motor activity (€225,000 total, €112,500 to L. Gheber).

9. 2009-1013, The Israel Science Foundation. Subject: Microtubule dynamics and kinesin-5 function during normal and aberrant anaphase spindle elongation ($160,000)

10. 2013-2018, The Israeli Science Foundation. Subject: The switchable directionality of the mitotic kinesin-5 motors: structural determinants, regulation by phosphorylation, and connection to intracellular functions ($560,500)


• Additional Information

Scholarships, grants and prizes awarded to research students 2010 Students’ travel award, ESF-EMBO Meeting Meeting, Emergent Properties of the

Cytoskeleton: Molecules to Cells, Sant Feliu de Guixols, Spain, 3 - 8 October 2010, awarded to Vladimir Fridman

2010 United States-Israel Binational Science Foundation (BSF) travel grant for young scientists (a travel grant to the USA), awarded to Adina Gerson

2009 Department of Chemistry award for excellence in research, awarded to Adina Gerson

2008 DAAD Short-term Fellowship awarded to Vladimir Fridman for Collaborative Research in the George Augustus University of Gottingen, Gottingen, Germany

2008-2010 Scholarship for Interdisciplinary M.Sc. studies awarded to Yael Nissenkorn by the Rector of BGU

2007-2011 The Negev Scholarship for Ph.D. studies awarded to Vladimir Fridman by the Kreitman School of Advanced Graduate Studies, BGU

2006 Bernard Cwikel prize for excellence in research, Faculty of Health Sciences, BGU, awarded to Vladimir Fridman



2004 First prize for the best poster - The 38th Annual Meeting of the Israel Society for Microscopy, Israel, awarded to Adina Gerson

Selected Lectures and Posters Delivered by Group members and Students

R. Avunie, V. Fridman, B. Katz and L. Gheber. Sensitivity of human cancer cell lines to

monatrol, a specific inhibitor of a mitotic kinesin-related protein. Joint Meeting of the Israeli Societies for Cell Biology and Developmental Biology, Eilat, Israel 2006

V. Fridman, I. Shumacher, N. Movshovich, B. Katz and L. Gheber, Spindle midzone organization during mid-anaphase pause induced by mutations in kinesin-5 motor proteins. European Life Science Organization (ELSO) Annual Meeting, Dresden, Germany, September, 2007

V. Fridman, N. Movshovich and L. Gheber. In vivo and in vitro functions of the S. cerevisiae kinesin-5 Kip1. European Molecular Biology Organization (EMBO) Annual Meeting, Amsterdam, Netherland, 2009

V. Fridman, N. Movshovich, S. Lakamper, C.F. Schmidt, and L. Gheber, Anaphase midzone

organization and motile properties of the S, cerevisiae Kinesin-5 Kip1. ESF-EMBO Meeting, Emergent Properties of the Cytoskeleton: Molecules to Cells, Sant Feliu de Guixols, Spain, 2010

V. Fridman, N. Movshovich, L. Gheber. In vivo and in vitro function of the S. cerevisiae kinesin-5 Kip1. Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

M. Podolskaya, A. Gerson-Gurwitz, C. Thiede, N. Movshovits, V. Fridman, S. Lakaemper, C.F. Schmidt and L. Gheber. The effect of mitotic spindle-binding proteins on the in


vivo and in vitro function of the kinesin-5 Cin8, 44th Meeting of the Israeli Society for Microscopy, Tev-Aviv, Israel, 2010

A. Gerson-Gurwitz, C. Thiede, N. Movshovits, M. Podolskaya, V. Fridman, S. Lakaemper, C.F. Schmidt and L. Gheber. In vivo and in vitro functions of Cin8, the S. cerevisiae mitotic kinesin-5 motor protein, Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

N. Movshovich, A.Gerson-Gurwitz, R.Avunie, M.A. Hoyt, B. Katz and L. Gheber, Spindle localization of the S. cerevisiae kinesin-5 Cin8 during anaphase spindle elongation, Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

Y. Nissenkorn, A. Zaritsky, and L. Gheber. Phosphoregulation of Kinesin-5 Cin8 during

Mitosis in S. cerevisiae, Genome Stability Meeting, BGU, Beer-Sheva, Israel, 2010

M. Podolskaya, A. Gerson-Gurwitz, C. Thiede, N. Movshovits, V. Fridman, S. Lakaemper,

C.F. Schmidt and L. Gheber, The effect of mitotic spindle-binding proteins on the in vivo and in vitro function of the kinesin-5 Cin8, 6th Congress of the Federation of the Israeli Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2011

A. Sorkin, V. Fridman, and L. Gheber, Influence of motor proteins on microtubule dynamics during late anaphase in S. cerevisiae cells, 6th Congress of the Federation of the Israeli Societies for Experimental Biology FISEB (ILANIT), Eilat, Israel, 2011

V. Fridman, A, Gerson-Gurwitz, C. Thiede , N. Movshovich, M. Podolskaya, S. Lakamper,

C.F. Schmidt and L. Gheber. Mitotic functions and motile properties of the S. cerevisiae Kinesin-5 motors. 55th Meeting of the Biophysical Society, Baltimore, USA, 2011 (oral presentation)

O. Shapira, A. Gerson-Gurwitz, M. Podolskaya and L. Gheber. Effect of phosphorylation on the motility of the biological nano motor Cin8. The 46th Annual Meeting of the

Israeli Society for Microscopy (ISM), Ben-Gurion University of the Negev, Beer-Sheva, Israel, May 2012

O. Shapira, A. Gerson-Gurwitz, M. Podolskaya and L. Gheber. Effect of phosphorylation on the motility of the biological nano motor Cin8, Nano Israel 2012, Tel Aviv, Israel,

March 2012

O. Shapira, A. Gerson-Gurwitz and L. Gheber, Effect of phosphorylation on the motility of

the biological nano motor Cin8, Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May, 2013

A. Goldstein, L. Holt and L. Gheber, Evolution of phospho-regulation of mitotic kinesin-5 motor protein, Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May 2013

N. Schkolnik and L. Gheber, Regulation of motor protein Cin8 by phosphorylation, Batsheva de Rothschild Symposium on Single Molecule Biophysics, Neve Ilan, Jerusalem Hills, Israel, May 2013

O. Shapira and L. Gheber. Phospho-regulation of kinesin-5 movement, The Annual

Meeting of the Israeli Live Imaging Forum on Super-Resolution and Advanced Imaging, Ben-Gurion University, Beer-Sheva, Israel, June 25, 2013 (oral presentation)

O. Shapira, A Gerson-Gurwitz and L. Gheber, Effect of phosphorylation on the motility of the biological nano motor Cin8, 9th European Biophysics Congress, EBSA2013, Lisbon, Spain July, 2013