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EXHIBIT 4

LCF Final 710 DEIR DEIS Comment Letter 8-4-15 - Part3

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LCF Final 710 DEIR DEIS Comment Letter 8-4-15 - Part3

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EXHIBIT4 Whatisa safe distance tolive or work near highautoemission roads?..http://sandiego.urbdezine.coml20 15/05/28/what-is-a-safe-distance-to-... SanDiegoUrbDeZine Urban Planning + Design + Architecture + Historic Preservation HOMERESOURCESFORUMURB MAINLOGIN Whatisasafedistanceto liveorworknearhigh autoemissionroads?May 28, 2015 by Bill Adams1 (omment A nearby roadway may beputting your household's health at risk.The same istrue of workplaces,schools,andother places where people spendsignificant time.This healthriskisfrom the elevated auto emissions near high traffic roadways.It's a healthriskseparateandin addition to the regionalair pollution from auto emissions. Wehave come to draw a false sense of security from our collective sharing of regional air pollution and, perhaps, the belief that regulatory agenciesprotect us.However, researchcontinues to show that air pollution, particularly from auto emissions,hasprofound effects onhealth.Moreover, suchimpacts are unequally distributed among localpopulations,largely basedonnearness to major roadways. Discussions about whether or not to build or expand roadways are dominated by the topicsof traffic congestionrelief,urban planning, andgreenhouse gasses.Theimpact of roadwayson Americans' health andmorbidity isoften lost in the discussions.53,000U.S.deaths annually are attributable to automObile emission air pollution. (Caiazzo,et aI.,2013)Many more are ill or incapacitatedfrom auto emissions.Ninety percent of thecancer risk from air pollution in Southern Californiaisattributable to auto emissions. (Hulsey,et aI.,2004,par.10)Forcomparison, there are 35,000 U.s.deaths a year from auto collisions (NHTSA,2012), which is the top cause of death for U.S. males between the ageof 15and 24,andin the top ten causesof deathof all Americans through the ageof 54. Theimpact onlife and safety generally from roadexpansionreceiveslittle attention.However, auto emission pollution basedonproximity to source, i.e.line-source pollution,isoneof the most overlookedhealth threats in the U.S.Current U.s.policies andregulations do little to protect susceptible populations, including children, from the dangers of nearnessto autoemission sources.Undoubtedly, the disproportionate lack of urgency concerning the health impacts of air pollutionisattributable to its hidden anddelayed impact.Althoughthehealth impacts of air pollution on general populations are certain,individual diagnoses of diseaserarely identify air pollution asthe cause.Asa result, thehealth threat fails to takeonthe personal dimension of other health threats.Thesame wastrue with smoking for many decades.Additionally, awareness of line-source pollution isfurther hinderedby confusion with regionalI ambient air pollution, whichtypically manifests inmore noticeable high ozonelevels,i.e.,smog. Air pollutionmonitored by various agencies includesparticulate matter (PM),ozone,nitrogen dioxide, carbon monoxide, sulfur dioxide, andlead.However,two of these causethe most concern due to their prevalence andhealth significance:1) Ozone,which causesthebrown smog commonly seenover cities and2)Particulate matter (PM),alsoreferredtoasultrafine particulates (UFP). Unlike ozone,PMexposure isdirectly related toproximity tosource - primarily areasnear toor downwind from high traffic areas.Moreover, for health impacts,PMpollutionmay be the worst of thelot.Heart disease,lung functionimpairment, leukemia, asthma, andlung cancer,are someof the conditions that havebeenassociated with PMexposure resulting from proximity tohightraffic sources. (Hulsey,et aI.,2004,par.6;Fuller,et aI.,2012, pp.257 - 265)Asstated in a 2002 study about exposuretohighway PMs: lof7 lWlTTER PETITION TOSTOP DEMOLITIONS INSANDIEGO FOR PARKING LOTS. Click the photo to signor learn more about the Petition. 5/29/20 159:52 AM What isa safe distance tolive or work near high auto emission roads?...http://sandiego.urbdezine.coml20 15/05/28/what-is-a-safe-distance-to-... Throughout the past decade,epidemiological studies have reported a consistent relationship between increases in particulate matter (PM) exposure and contemporary increases inmortality and morbidity. (Zhu,et al., 2002) AmbientUFP - DeposItIon In the respiratory tract 1'TranslOcation tlir(IUiJli drcutali(m ~ ' * - Y T __ I -Heart BraIn~'TyaltSfocalion via ollwory JUrve to olfactoryDun; '_naL,Figure 17.HypothesizedpathwaysviawhichInhalationofUFPsmayleadtoeffectsoncardiovascular and respiratorysystemsandonthe brain.ReprintedwithpermissionfromtheHealthEffectsInstitute. BostonMA. Childrenareespeciallyvulnerabletoauto-emissionhealthimpactsbecause.amongotherreasons.theybreathemoreairrelativetotheirbodyweightthanadults.aremorephysicallyactive. andspendmoretimesoutdoorsduringtimeswhen pollutantlevelsareattheirhighest.(Hulsey,etaI.,2004)Additionally.childrenhavemanymoreyearsahead oftheminwhichthecumulativedamagecaused byautoemissionscan manifestitselfindiseaseordisability.Womenwho livenearareasofhighautomobiletrafficduringpregnancyhavea20- 30%higherchanceofhavingchildrenwithlungimpairment.(Morales.etaI.,2014)AutoemissionPMexposurefromnearnesstohightrafficduringthethethirdtrimesterofpregnancydoublestheriskforautism.(Raz, etal..2014).11% ofU.S. residents,over30millionpeople,livewithin100metersof4laneorgreaterhighways. (Brugge,etal..2007;Howard,2011) Addinginworkplaces,schools,andcommuting.itIs reasonable toextrapolatethatroughly1/3 ofpeoplespendasubstantialportionoftheirday exposedtounhealthylevelsofautoemission PMs. Sohowcanyoudetermineyourownexposurelevelorthatofyourchildren? Belowaresomekey distancesandotherfactors: Ground Zero: Curbsideandin-trafficaircontainshighlevelsofallpollutantsassociatedwithautoemissions-bothPMsandgaseoussubstanceslikebenzeneandcarbon monoxide.(Hulsey,etal..2004.par.7) PM exposureatintersectionsisasmuchas29timeshigherthanotherportionsofthe road.(Goel &Kumar.2015) Cyclists.autooccupantswithwindowsdownorventsopen.tollboothoperators, androadsideresidentsandbusinessesreceiveupto25timesthelevelofPM exposure. (Zhu.et aI.,2002)Moreover,theairInsideacartypicallycontainshigherconcentrationsofthesepollutants thantheairoutsideofthecar- as muchas4timesthebenzeneand 10timesthecarbon monoxide.(laA.2000) Keepingthewindowsclosedandtheventilationsettorecirculatecan reducein-carpollutantsto20%thatofairoutsidethecar.(l.A.Times,2013) High Toxicity Zone -300 -500 feet: Onaverage.PM concentration is significantlyhigherwithin330feet(100meters)ofmajor highwaysthanitisfurtheraway.(Zhu,etaI., 2002) ThesmallestPMs.withapeakconcentrationof 1.6x1 0(5)/cm3,arethemostdangerous.SmallerPMscarrytoxicsubstancesdeeperintothe lungs andbody,andasaresult.havemoreprofoundhealtheffects.(Cal. EPA, Aug.2014.p.29)Theyare concentratedinan areawithin330feetfromhighways.(Zhu, supra) Pregnantwomenwholive 20f75/29/20159:52 AM What isa safe distance tolive or work near highauto emission roads?...http: //sandiego.urbdezine.comJ2015/05/28/what-is-a-safe-distance-to-... within 500 feetof hightraffic areas areprone to birth complications, including premature birth, low birth weight children, andchildren with medicalproblems. (Wilhelm &Ritz,2003) A review of a broad range of studies has correlated early mortality - from a wide range of illnesses - with living within 330 feet of a hightraffic roadway andrelatedexposure to various auto emission substances. (Beelen,et aI., 2008) Figure 3.2.6-4: Sensitive ReceptorLocations (Springdale Street to Warner Avenue)May 2012, 1-405 Improvement Project return tonear normal beyond that distance. Elevitted Toxicity Zone -1,000 -l,5UO feet: PMsfrom auto emissions areelevatedwithin 1,000 feet (300 meters) of a major highway. (yifang, et al ., 2002,pp. 1038-1039)A Denver study indicated that children living roughly within that distancewere eight times aslikely todevelop leukemia andsix times as vulnerable to all types of cancer.(Hulsey,et aI., 2004,- par. 1)[n another study, children under 5 years of ageadmitted tohospitals with asthma emergencies were significantly more likely to live within 500meters (1 ,640 feet) of a major highway when traffic flow exceeded 24,000 vehiclesper hour than those who lived further away or whentraffic flow wasless. (Edwards& Walters,1994)Particle levels Other FactorsInfluencing Air PollutionLevels Near Roadways: Wind: Peopleliving "downwind" ofhighways with 4 or more lanes (2lanes ineachdirection) are exposed to higher levelsof fine particulate matter. (Brugge,et al. 2007) However, thiscircumstancedoes not exempt one side of a highway fromPMdangers.In many regions, wind direction changesnot only depending on weather conditions, but alsobetween day andnight. Sun, Rain &Humidity: Areasreceiving higher amounts of rainor humidity canexperiencereducedauto-emission pollution levels, especially ultra-fine particulate pollution.Thecleanair yousense after a rain stormreally iscleaner.Thisfact isregularly demonstrated inhigh-pollution Bejing. (USA Today, Aug.11,2008)Atmospheric conditions alter the size,distribution, andcomposition of freshly-emittedPMthrough condensation, evaporation, anddilution during transport to downwind locations. (Brugge,et aI., 2007)Thus, higher humidity levels cantamp down the distribution of PMs.(HEIReview Panel , 2013,p.24)Conversely,sun,heat, andlackof humidity generally favor greater distribution of PM.Additionally, ground levelozone concentration is unhealthieston sunny and warm days. Topography: PM,aswellas gaseous air pollutants, tend to concentrate in valleys due to containment by topographicalfeatures. (HEIReview, supra)Inversions,in which a layer of cold air is trapped underneath a layer of warm air, keepPMconcentrated near groundlevel andaggravate theconcentration of PMin valley andcanyon floors.Ibid.Fogisoften A temperature inversionina valley - clean air poster anindicator of aninversion. from a Teacher's Guideto CleanAir by BC Transit, Nov. 2005- republishedpermissionMinistry of Environment,BritishColumbiaCanadaTime: Thetime of day caninfluence PMconcentrations near highways - both in terms of traffic 30f75/29/20159:52 AM What isa safe distance tolive or work near highauto emission roads?...http://sandiego.urbdezine.com/20 15/05/28/what-is-a-safe-distance-to-... concentrations andintermsofweather.(HEI Review Panel,supra) Ofcourse, highwaysexperiencemuch highertrafficconcentrationsatcertain timesoftheday. However,suchconcentration hasbecomelessvaried as employersstaggerworkshiftstoalleviatecommutingburdensand ascontinuedhighwayexpansioncreatesInduceddemand(tendencyoffreewayexpansion tocreatemoredemandand congestion in the longrunbyfacilitatingsprawl). Additionally, the heatingandcoolingofdayand nighteffectpollutionconcentrationsatgroundlevel.AutoEmissionAir Pollution as aSocial Justice Issue: The unavoidableconclusion from theresearch isthateach timeamajorhighwayis builtorexpanded,some ofthe residentslivingnearbywill paywiththeirhealthorlives. Nevertheless,compared toindustrialusesthatposepotential healthrisks, roadwayconstructionprojectsremainrelativelyunregulatedas adirectairpollutionhealth risk. (Hulsey, et aI.,2004)The same is trueofthesitingofresidential, employment,senior, oreducational uses nearhighways.Lowincomeand minoritypopulationsaredisproportionatelyimpacted byairpollutionhealthrisks.(Beleen, 2008)Suburban expansioncreatesademandforroad expansion throughexistingneighborhoods. Lowerincomeneighborhoodsand ethnicminoritypopulationsleastoftenwie'ldthepoliticalinfluencenecessarytoresist road expansionprojects. Additionally,multifamilyand affordablehousingis morelikelytobe sited nearhigh trafficareasthan is moreexpensive detached housing,Morerecently, theconstructionofhigh density"transitorienteddevelopments"(TODs),whichare intendedtoreduceauto reliance andwhichoftenincludeaffordablehousing,are frequentlysitednearhightrafficareas. There hasbeen littleacknowledgementin U.S.transportation policyofthesocial inequalityandtheethicalissues related tosacrificingthehealthofmembersofonecommunityto facilitate thegrowthand commutingofanothercommunity,Propertycondemnedforaroad expansionprojectresults in monetarycompensationto theownerbased on fairmarketvalue. However,residentsputatrisk bythe additionaltrafficemissionsas aresultoflivingadjacenttoorneartheroad projectcannotrecovercompensationorassistance torelocate.Constructionand expansionofroadwaysmayinvolvesomepublicdisclosureofhealth impactsviaenvironmentalreportingdocumentsbutthereportingtendstoassumethat"nobuild"highwayexpansion optionswillsimplyresultin ever increasingcongestion. However, morethanahalfcenturyofhighwaybuildinghas demonstratedthatcongestion relieffrom road expansion tends tobe temporary,and thatthelongterm impactis increasedautomobileuseand trafficcongestion.Such "induceddemand" is increasinglyrecognized as thelongtermeffectofexpandingroadwaysto relievecurrenttrafficcongestion,Increasingly, line-sourceproximitytoautoemission pollutionand therefinementand improvedaccuracyofroadwayairpollutiondispersion modelingisbeingused in legal and poli ti calchallengestohighwayexpansion proposals.Given thestakes,itshardtojustifythecontinuedexpansion ofroadwaysinurbanareas, theslownessofconversion to non-combustiblefuelautomobiles,orthe proportionatelysmall investmentinpublictransit. Ifsuch decisionswerebased solelyon healthcriteria proportionatetootheridentifiedpublicrisks, highwaysmightbequarantinedasan acutelyelevated healthhazard tothosewholiveorworknearthem,Ofcourse,suchaction Is impracticalas itwould resultinvasttractsofexistinghomes,schools, and places ofemploymentbeingabandoned,.......... ...... ..IIIttI.-..I__""""t"'" .--.....-Cincinnatihighwayproximityhealthhazards.Republished permission LADCOItisclearthatthepublicisstillnotfullyawareofthe differencebetweenambi entai rpollutioneffectingthe WARNING: Arc.... ,.,ithi ...1nM40f75/29/20159:52 AM What isa safe distance tolive or work near highauto emission roads? ...http: //sandiego.urbdezine.com/2015/05/28/what-is-a-safe-distance-to-.. . general populace of a city and line-source air Areas within1,000 pollution impacting health basedonnearness to feet of major highways.Perhaps,if thepublic wasmore aware of theroadways contain direct andunequalhealth impacts of high-trafficsubstances known to roadways,transitioning from roadway expansiontocause respiratory transportation alternatives would receivemoreillness,heart disease, urgency.Oneproposalfor an air quality district plan in cancer,and reproductive harm. California requiredthat builders of homes, schools,or day carecentersprovide notice to their customers of toxic emiSsions,including those emanating frombusy roads,within 1,000 feet.(Hulsey,2004,p.13) Without a better understanding of linesource proximity exposure by the general pub'lic,its hard to foresee substantial changes.It may take activism andinformation campaigns, suchasposting warning notices inneighborhoods within the1,000 foot zone,to catch the public's attention and educate it onthishealth issue. Notes: While this article cites a number of scientific articles, some "rounding" isusedfor the purpose of readability.In other words,this article attempts toorganizeand summarize current available data into a general conceptualframework for general public understanding rather than to provide new data. References: caiazzo,F.,Ashok,A.,Waitz,I.A.,Yim, S.H.L.,Barrett, S.R.H. (2013) Air pollution and early deaths In the United States.Part 1:Quantifying the impact of major sectors In 2005, Laboratory for Aviation and the Environment, Department of Aeronautics and Astronautics,Massachusetts Institute of Technology, August 2013. Zhu, Y.,Hinds, W.e.,SeongheonKim,S., andSioutas, e.(2012) Concentration and SizeDistribution of Ultraflne Particles Near a Major Highway,journal of the Air & WasteManagement Association, vol . 52 Fatality Analysis Reporting System (2012) fars.NHTSA.dot.gov Morales,E.,GarciaEsteban,R. ,Asensiode laCruz,0.,Basterrechea, M.,Lertxundi, A.,Martinez LopezdeDicastillo,M.D.,Zabaleta,e., Sunyer, j. (2014) Intrauterine and early postnatal exposure to outdoor air pollution andlung function at preschool age. Thorax,2014;See also,BMjBritish Medical journal; SeealsoExposure to traffic pollutionduring pregnancy candamage future child's lungs. ScienceDaily,20October 2014. Howard,E.(2011) Every Breath YouTake, TuftsNow,November 2,2011 Brugge,B.,Durant, j.L., Rioux,e. (2007) Near-highway pollutants Inmotor vehicle exhaust: A review of epidemiologic evidence of cardiac andpulmonary health risks, Environmental Health, Autust 9,2007, 6:23 Goel, A.and Kumar,P.(2015) Characterisation of nanoparticie emissions and exposure at traffic intersections through fast-response mobile and sequential measurements Atmospheric Environment, Vol.107, April 2015,pp.374-390 Hulsey, B.,Hopkins,E.,Olson, E., Burg,E., andCarlson,M. (2004) Highway HealthHazards:How highways and roads cause health problems In our communities- and what you cando about it. Sierra Club,2004, 6 Draft Environmental Impact Report! EnvironmentalConsequences, andEnvironmentalImpact Statement Avoidance,Minimization, AndlOr Mitigation Measures. 1405 Improvement Project. May 20123.2.622 Fuller, e.H., Brugge, D. Williams, P.,Mittleman, M.,Durant, j.L., and Spenglera, j . D. 50f75/29/20159:52 AM What isa safe distance toliveor work near highauto emission roads? ...http://sandiego.urbdezine.com/20 15/05/28/what-is-a-safe-distance-to-... (2012)Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors, AtmosphericEnvironment, Volume 57,September 2012,Pages 257-265 Yifang.Z,Hinds, W.e.,Seongheon,K.,Shen,S.,Sioutas,e.Concentration and sizedistri bution of ultrafine particles near a major highway. journal of the Air and WasteManagement Association. September 2002,pp.1038-1039. Beelen,R., Hoek,G., A. vandenBrandt,P.,Goldbohm, R.A.,Fischer,P.,Schouten,L.j., jerrett, M., Hughes,E.,Armstrong,B., andBrunekreef,B.,long-TermEffects ofTraffic-Related Air Pollution on Mortality i n a Dutch Cohort (NLCS-A1R Study),EnvironmentalHealthPerspectives (vol.116, no. 2, Feb.2008) Rain,rain; Beijing air pollution washes away, August11, 2008 - USA Today In-Car Air Pollution: The Hi dden Threat to Automobile Drivers. International Center for Technology Assessment (lCTA). july 2000 , page S. Borboza, T.,For cleaner air, set car vents to 'recirculate: study saysSeptember 12,2013,LA Times. Cal i fornia Communiti esEnvironmental Health Screening Tool , Version2.0 (Calenviroscreen 2.0) Guidance AndScreening Tool , Californi a EnvironmentalProtection Agency (August 2014),p.29. HEIReview PanelonUltrafine Particles.2013. Understanding the Health Effects of Ambient Ultrafine Particles. HEIPerspectives 3. HealthEffects Institute, Boston,MA,p. 24 Wilhelm, M. andRitz,B., Residential Proximity to Traffic and Adverse Bi rth Outcomes InLos Angeles County, EnvironmentalHealth Perspectives(vol.111, No.2, Feb. 2003) Edwards, j.; S. Walters,et al ., Hospitaladmissions for asthma in preschool chil dren: relationship to major roads InBirmingham, United Kingdom. Archives of EnvironmentalHealth. (49(4): 223-71994) SanDiegoFreeway (140S) SupplementalDraft Environmental Impact Report IEnvironmental Impact Statement, Figure 3.2.64 Sensitive Receptor Locations, CaliforniaDept. of Transportation (2013) (freeway widening project) Raz,R., Roberts, A.L.,Lyall,K., Hart. j .E., just, A.e.,Laden, F., andWeisskopf,M.G., Auti smSpectrum Disorder and Part iculateMatter Air Pollutionbefore, during. andafter Pregnancy: A Nested Case-Control Analysiswithin the Nurses'Health Study II Cohort, EnvironmentalHealth Perspectives (2014) FiledUnder:Ecology, environmental health, Fture Posts, San Diego, Tr.lnSportatlonTagged With: air poll ution, emissions, particulatematter, PM, UFP, ultra fi ne particulates About Bill Adams Bill Adamsisthe founder and chief editor of UrbDeZine.Heisalso a partner in the SanDiegolaw firm of Norton, Moore, & Adams,LLP.Hehasbeen Involved with landuse andurban renewalfor nearly 25 years,both asa profeSSional and asa personal passion. Hecurrently sits on the Boards of SanDiego Histor ic Streetcars, The San Diego Architectural Foundation, The Food andBeverage Association of SanDiegoCounty, and The Gaslamp Quarter AssociationLandUsePlanni ng Committee. Norton, Moore, & Adams,LLPisa boutique land use firm whichhandles a wide rangeof land and building relatedmatters, frompermitting to litigation, including: - Discretionary use applications and appeals,Including alcoholic beverage sales, entertainment, Industrial, social services, educational,hospitality,etc. - Zoning variances - Municipal code andregulatory amendments - Litigation, i ncluding eminent domain, access andeasements,CEQA.environmental, and 60f75/29/20159:52 AM Whatisa safedistance tolive or work near highauto emission roads? ...http: //sandiego.urbdezine.com/20 15/05/28/what-is-a-safe-distance-to-... preservationProfessionalwebsite:www.nmalawfirm.comComments Saamsays:May 28, 2015 at 8:39 am Thanksforconsolidatingso much materialand data intooneplace!Thiswas trulyinformative. log into Reply Speak Your Mind You mustbe loggedintopostacomment.RETURN TOTOP OF PAGE COPYRIGHT2015NEWSTHEME ON GENESIS FRAMEWORK,WORDPRESS ,lOGINI70f7 5/29120159:52 AM EXHIBIT5 SouthCoastAirQualityManagementDistrict21865 CopleyDrive,DiamondBar,CA 91765-4182(909)396-2000 www.aqmd.govSCAQMDAirQualitySignificanceThresholdsMassDailyThresholdsaPollutant ConstructionbOperationCNOx 100lbs/day 55lbs/dayVOC 75lbs/day 551bs/dayPMIO 150 Jbslday 1501bsldayPM2.S 55lbs/day 55lbs/daySOx 150lbs/day 1501bsldayCO 550lbs/day 550lbs/dayLead 3lbs/day 3lbs/dayToxicAirContaminants(TACs),Odor,andGHGThresholdsTACs(includingcarcinogensandnon-carcinogens)MaximumIncrementalCancerRisk;::: 10 in I millionCancerBurden>0.5 excesscancercases(inareas;::: Iin Imillion)Chronic&AcuteHazardIndex;::: 1.0 (projectincrement)F Odor Projectcreatesanodornuisancepursuantto SCAQMDRule402GHG 10,000MT/yr C02eqfor industrialfacilitiesAmbientAirQualityStandards(orCriteriaPollutantsd N02I-houraverageannualarithmeticmeanSCAQMDis in attainment;projectis significantifitcausesorcontributestoan exceedanceofthefollowing attainmentstandards:0.18ppm(state)0.03 ppm(state)and0.0534ppm(federal)PMIO24-houraverageannualaverage10.4llg/m3 (construction)e&2.5 Ilg/m3(operation)1.0 f..I.g/m3PM2.S24-houraverage 10.4Ilg/mJ(construction)e&2.5 llg/m3(operation)S02I-houraverage24-houraverage0.25 ppm(state)&0.075 ppm(federal- 99thpercentile)0.04ppm(state)Sulfate24-houraverage 25llg/m3 (state)i COI-houraverage8-houraverageSCAQMDis in attainment;projectis significantifitcausesorcontributestoanexceedanceofthefollowing attainmentstandards:20ppm(state)and35 ppm(federal)9.0ppm(state/federal)Lead30-dayAverageRolling3-monthaverage1.5Ilg/m3 (state)0.15Ilg/m3(federal)aSource: SCAQMDCEQAHandbook(SCAQMD. 1993) hConstructionthresholds applytoboth the SouthCoastAirBasinandCoachellaValley(SaltonSeaandMojaveDesertAirBasins). , ForCoachellaValley, themassdailythresholds for operationare thesameastheconstructionthresholds. d Ambientairquality thresholds forcriteriapollutantsbasedon SCAQMDRule 1303,TableA-2 unless otherwisestated. e Ambientairqualitythresholdbasedon SCAQMDRule403. KEY: Ibs/day =poundsperday ppm partspermillion j.lg/mJ microgrampercubic meter ::>: greaterthanorequalto MT/yrC02eq=metrictons peryearofC02equivalents > =greaterthan Revision: March 2015EXHIBIT 6 A Section SOB-conformant HTML version of this article is available at http://dx.doi.org/10.1289/ehp.1408565.Research Associationsof Mortality with Long-TermExposures to Fineand Ultrafine Particles, Species andSources:Results from the California Teachers Study Cohort Bart Ostro,1 Jianlin Hu,2 Debbie Goldberg,3 Peggy Reynolds,3 Andrew Hertz,3 Leslie Bernstein,4 and Michael J.Kleeman2 'Air PollutionEpidemiology Section,CaliforniaOfficeofEnvironmental HealthHazard Assessment, Oakland,California,USA; 2Department of CivilandEnvironmentalEngineering,University of California,Davis,Davis,California,USA;3Cancer PreventionInstitute of California,Berkeley,Berkeley, California,USA;4City of HopeNationalMedicalCenter,Duarte, California,USA BACKGROUND:Although several cohort studiesreport associationsbetween chronic exposuretofine particles(PM2.5)andmortality,fewhavestudiedthe effectsof chronicexposuretoultrafine(UF) particles.Inaddition,fewstudieshaveestimatedthe effectsof theconstituents of eitherPM2.5or UF particles. METHODS:Weusedastatewide cohort of>100,000womenfromtheCaliforniaTeachersStudy whowerefollowedfrom200 Ithrough2007.Exposuredata attheresidentiallevelwereprovided byachemicaltransportmodelthatcomputedpollutant concentrationsfrom>900sourcesin California.Besidesparticlemass,monthly concentrationsof IIspeciesand8sourcesor primary particles were generatedat4-km grids.We usedaCox proportional hazardsmodelto estimatethe associationbetweenthepollutantsand all-cause,cardiovascular,ischemicheartdisease(IHD),and respiratory mortality. RESULTS:Weobservedstatistically significant(p1.30.000 curren tandformerfemaleteachersand adm inistratorsiden tifiedth roughtheState TeachersRetirementSystem.Becauseof limiteddataonparticlespecies.thisearlier reportreliedonPM2.5 datacollectedand furtheranalyzedbytheU.S.EPAateight fixed-sitemonitorsa.spartof theSpeciation TrendsNetwork(U.S.EPA2(08). '[he 24-hr averagedmeasurementswereusuallyobtained onaneverythird- orsixth-daybasis.To minimizeexposuremisclassification.catch-mentbuffer areasof 8and .30km weredrawn aroundeachmonitor.The.30-kmbufferis likelytoolargetocaptureexposurecontrasts of many of thespecies.whilethe8-kmbuffer significantly reducedthe sample size.resulting inmoreunstable estimatesandreducedstatis-ticalpower.Althoughthesebufferswerean improvementoverstudiesusingasingleor multiplemonitorstorepresentexposureover largemetropolitanareas.theymaynotsuffi-ciently measure concentrationsof many of the PMconstituents.suchasc1emenralcarbon (EC)andtransitionmetalsthatareknown AddresscorrespondencetoB.Osrro,OEHHA,2008 Tampa Ave.,Oakland,CA94611USA.Telephone: (510)339-3379.E-mail:[email protected] SupplememalMaterialisavailableonline(http:// dx.doLorg/I0.1289/ehp.14085(5). FundingforthiseffortwasprovidedbygrantRO I CA77398fromtheNationalCancerInstitute,con-tract97-10';00fromtheCaliforniaBreastCancer ResearchFund,andSTAR grantR833372fromthe U.S.EnvironmentalProtection Agency(EPA). Althoughtheresearchdescribedinthearticlehas beenpartiallyfundedbytheU.S.EPA,ithasnotbeen subjecttolheagen(.)"srequiredpeer andpoli(.)'review andthereforedoesnotnecessarilyreflecttheviews of theagencyandnoofficialendorsement shouldbe inferred.AllP M 2 ~ andultraflnePMexposuredata usedinthepresentstudyisavailablefreeof chargear http://faculty.engincering.ucdavis.cdu/kleeman/. 11,e authors declaretheyhaveno actua I or pottntial competing financialinterests. Received:15April2014:Accepted:22January 20 IS:AdvancePublication:23January2015:Final Publication:1 June 2015. 549 Ostroet al. toexhibithighspatialvariance.Specifically. Huer,II.(2014a.2014b)reportedsigniH-cantbiasforseveralspeciesof HneandUF particleswhencomparingthecentral-site monitorreadingsappliedtotheentiremetro-politanareapopulationversusouresdmated population-weightedconcentrations.The latterarederivedastheproduct(bothatthe 4-kmgridscale)of thepopulationandour modd-based estimatesof the pollutants. Modelestimatesarehighlycorrelated (r> 0.8)withobservationsatthemonitoring locations.ButforthesevenmajorCalifornia MetropolitanStatisticalAreasthathadavail-abledata.theestimatedpopulation-weighted concentrationsforECweregenerallylower thancentral-sitemonitorpredicdons.with amaximumbiasof -50%inLosAngeles. California,andanavcragebiasof -33%. Althoughmeasurementandmodelpredic-tionswereingoodagreementatthemonitor locations,thebiaswasintroducedbyspatial variability aroundthemonitor. Forthepresentstudy,wecombineddata ff()mtheCTS withnewlydevelopedexposure data generatedfromthe UCD/CIT (University of CaliforniaDavis/CaliforniaInstituteof Technology)SourceOrientedChemical Transportmodel.TheUCD/CITchemical transportmodelusescalculatedmeteorological .ieldsandemissionsestimatesfordifferent sourcesropredictairborneparticulatematter concentrations.Parriculatematteremissions areassignedasi:teandcompositiondistribu-tionbasedonmeasuremenrsinsource-testing cxpcrimems.111esource-identity of allparticu-latematter emissionsisretainedthroughthe simulatedatmosphere.Inthepresentstudy, ground-levelmassconcentrationsfor50PM constituentswereestimatedoverthemajor populationregionsinCaliforniaata4-km resolutionfortheperiodof 2000-2007.For many speciesof fineandUFparticles,model predictions arehighly correlated withmeasured values,particularlyforlongeraveragingtimes (>2weeks).Forexample,correlationswere > 0,8 for comparisons betweenannualmodeled andmeasuredconcentrationsof 10different PM2.5 componentsforfiveof the sevenmetro-politanregionswithavailablemonitoringdata (Hu ctal.2014b). Below,wereportourfindingsof an analysisoftheassociationsof long-term exposuretoJ9constituentsandsourcesof hothPM2.5andUFparticlesonmortality fromallnaturalcauses,cardiovascular disease,ischemicheartdisease(IHD),and pulmonary disease. Methods Data.TheCTSisaprospectivestudyof 133,479currentandformerfemaleteachers andadministratorswhocompletedbaseline questionnairesmailedtothemin1995to investigatetheincidenceof breastcancerin public schoolreachersandadministrators.as describedindetailbyBernsteinetal.(2002), Subsequentquestionnairesweremailedto CTSparticipantsin1997and2000.The designandongoingfollow-upof theCTS cohortisamulti-institutionalcollaboration involvingresearcherswithdiverse and comple-mentaryareasof expertise.Recordlinkageis conductedannuallytomortaliryfilesadminis-teredbytheCaliforniaDepartment of Public Health.Inaddition.residentialaddressesof eachCTSparticipant wereupdatedannually forthemailingof newsletters.Themean ageof CTSparticipantsatenrollmenrwas 54 years,with90%between30 and80 years. Thecohortismulti-ethnicburprimarily non-Hispanicwhite(86.7%)andborninthe UnitedStates(93.6%).Forthisstudy,we usedcohort follow-updata fromJanuary 2001 through July2007.Women