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NMDA-Receptor Activation Induces Calpain-Mediated b -Catenin Cleavages for Triggering Gene Expression. Kentaro Abe et al., Cell, (2007). NEURONAL ACTIVITY. - REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY - PowerPoint PPT Presentation
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NMDA-Receptor Activation InducesCalpain-Mediated -Catenin Cleavages
for Triggering Gene Expression
Kentaro Abe et al., Cell, (2007)
- REGULATION OF DENDRITIC BRANCH STABILITY BY NEURONAL ACTIVITY
- ACTIVITY-DEPENDENT MODULATION OF LOCAL CYTOSKELETON AND ADHESION MOLECULES
- REGULATION OF DENDRITIC DEVELOPMENT BY ACTIVITY DEPENDENT GENE EXPRESSION
Chen Y et al., J Neurobiol, (2005)
NEURONAL ACTIVITY
Chen Y et al., J Neurobiol, (2005)
LTP ( long-terrm potentiation)
Memory formation
NMDA (N-methyl-D-aspartate) receptor
Cooke SF et al., Brain, (2006)
Calpain (calcium-dependent, non-lysosomal cysteine protease)
Franco SJ et al., J Cell Sci (2005)
Calpain regulates cell migration
Franco SJ et al., J Cell Sci (2005)
Motility-related calpain substrates of Calpain
Franco SJ et al., J Cell Sci (2005)
Activity-Dependent Cleavages of -Catenin by Calpain
AVP : NMDA-R antagonist
CNQX : AMPA-R antagonist
MCPG : mGluR antagonist
MDL28170 : calpain inhibitor
Activity-Dependent Cleavages of -Catenin by Calpain
MDL28170 : calpain inhibitor
Nuclear Translocation of Cleaved -Catenin Fragments
AVP : NMDA-R antagonist CNQX : AMPA-R antagonist
MCPG : mGluR antagonist MDL28170 : calpain inhibitor
Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments
AVP : NMDA-R antagonist, MDL28170 : calpain inhibitor
Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments
MDL28170 : calpain inhibitor
Activation of Tcf-Dependent Gene Transcription by the -Catenin Fragments
Calpain-Dependent -Catenin Cleavage and Tcf Activation In Vivo