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8/13/2019 Jurnal Ruth
1/23
Literature
review
N e u r o l o g i c a l s o f t s i g n s i n f i r s t e p i s o d e p s y c h o s i s
p r e s e n t e d b y :
H e n d r i 0 4 - 1 1 8
M a n u e l m a y e r a r i o 0 6 - 1 6 7
S h a n d y w i l l i a m t u w a n o t a 0 7 - 0 0 !
" o n i p a n o # u s i m b o l o n 0 7 - 0 0 4
M e r i a n i i t a $ a r o l i n a 0 7 - 0 6 4
% & ' ( ) * + ) & + ) + ) m , 0 7 - 0 6
* o b e r t u s a r i s m a h a r y a d i 0 8 - 0 4 6
* u t h n a t a l i a 0 8 - 0 1
. r i n $ i a b u n # a r a n t e a l l o 0 8 - 0 !
/ a m e l a a $ t i n i n a s r i r u m a t a 0 8 - 0
e a s y r i 2 a 0 8 - 0 4
8/13/2019 Jurnal Ruth
2/23
8/13/2019 Jurnal Ruth
3/23
&)MS
To review studies that havespecifically investigated NSS asthe time of the first psychotic
episode
8/13/2019 Jurnal Ruth
4/23
M9H
A review of studies investigatingneurological function in the first
episode psychosis, using a clinical
examination.
8/13/2019 Jurnal Ruth
5/23
results
The patient with first episode psychosisshow an excess of NSS, particularly in the
areas of motor coordination andsequencing, sensory integration and in
developmental reflexes. urthermore,NSS may be associated with a specific
laterality pattern.
8/13/2019 Jurnal Ruth
6/23
)S3SS)'Neurological sign in schizophrenia are concentrated in three main
domains!
Sensoryintegration
"otoriccoordination
"otorsequencing
#rimitivereflexes
&udio-visualinte#ration
9andem wal .ist-rin# test 5a2e
stereo#nosis *apid alternatin#movement
.ist-ed#e-palmtest
/almomental
5raphaestesia .in#er thumbopposition
s2eretsi test Snout
eti$ntion .in#er-nose test 5rasp
*i#ht-le;t$on;usion *hythm tappin#
8/13/2019 Jurnal Ruth
7/23
is$ussionThere were $ studies from %$&$ to '((( using ) different neurologicalclinical examination!
%.Neurological *valuation Scale +uchanan-einrichs, %$&$/
'.0ondensed Neurological *xamination +1ossi et al, %$$(
2.Standard neurological examination
3.Neurological examination +adapted from 4uit5in et al, %$67/
).The Scottish Schizophrenia 1esearch 8roup, %$&6
8/13/2019 Jurnal Ruth
8/23
8/13/2019 Jurnal Ruth
9/23
/revalen$e o; 'SS in healthy $ontroluen$in# < in
sensory inte#ration and in developmental re;lees 9hese anomalies are ;ound parti$ularly in males
and in sub=e$ts with lower edu$ation< and possiblyin those with a more severe $lini$al pi$ture,
8/13/2019 Jurnal Ruth
19/23
$on$lusion
9he presen$e o; neurolo#i$al abnormalities $annot be
eplained away as $onse>uen$es o; neurolepti$ use