Postpartum Hemorrhage

Jorge Garcia, MDDecember

Goals of talk

Definition Rapid diagnosis and treatment Review risks

Case 1.

Healthy 32 yo G2P1. Augmented vaginal delivery, no tears. Nurse calls you one hour after delivery

because of heavy bleeding. What do you do? What do you order?

Definition

Mean blood loss with vaginal delivery: 500cc

> 1000cc is “hemorrhage” Mean blood loss with C/S: 1000cc >1500cc is “hemorrhage” Seen in ~5% of deliveries.

Early vs. Late

. defines it as <24h. Late hemorrhage is more likely due to

infection and retained placental tissue.

Prenatal Risk Factors

Most patients with hemorrhage have none. Pre-eclampsia (RR 5.0) Previous postpartum hemorrhage (RR 3.6) Multiple gestation (RR 3.3) Previous C/S (RR 1.7) Multiparity (RR1.5)

Intrapartum Risk Factors Prolonged 3rd stage (>30 min) (RR7.5) medio-lateral episiotomy (RR4.7) midline episiotomy ( RR1.6) Arrest of descent (RR 2.9) Lacerations (RR 2.0) Augmented labor ( RR1.7) Forceps delivery (RR 1.7)

Easy to miss

Physicians underestimate blood loss by 50% Slow steady bleeding can be fatal Most deaths from hemorrhage seen after 5h Abdominal or pelvic bleeding can be hidden

Always look for signs of bleeding

Estimate blood loss accurately. Evaluate all bleeding, including slow

bleeds. If mother develops hypotension, tachycardia

or pain…rule out intra-abdominal blood loss.

Initial Assessment

Identify possible post partum hemorrhage. Simultaneous evaluation and treatment. Remember ABCs. Use O2 4L/min. If bleeding does not readily resolve, call for

help. .

ALSO’s 4 Ts

Tone (Uterine tone) Tissue (Retained tissue--placenta) Trauma (Lacerations and uterine rupture) Thrombin (Bleeding disorders)

“Tone: Think of Uterine Atony”

Uterine atony causes 70% of hemorrhage Assess and treat with uterine massage Use medication early Consider prophylactic medication...

Bimanual Uterine Exam

Confirms diagnosis of uterine atony. Massage is often adequate for stimulating

uterine involution.

Medications for Uterine Atony

1. Oxytocin promotes rhythmic contractions.

Give IM or IU, not IV. (Can cause BP) 40U/L at 250cc/h. 2. Methergine 0.2mg (1 amp) IM 3. Hemabate 0.25mg IM q 15min (max X8).

Medications: Methergine

Causes tetanic uterine contraction. May trap placenta. Can cause Hypertension, especially IV. Contraindicated in hypertensive patients

and those with pre-eclampsia.

Prostaglandin F2 15-methyl

Hemabate 0.25mg IM or IU. Used to be called Prostin. Controls hemorrhage in 86% when used

alone, and 95% in combination with above. Can repeat up to eight times. Contraindicated in active systemic diseases. Can cause nausea/vomiting/diarrhea, BP.

PGE1 PGE2

Tissue: Retained placenta Delay of placental delivery > 30 minutes

seen in ~ 6% of deliveries. Prior retained placenta increases risk. Risk increased with: prior C/S, curettage p-

pregnancy, uterine infection, increased parity.

Prior C/S scar & previa increases risk (25%) Most patients have no risk factors. Occasionally succenturiate lobe left behind.

Abnormal Placental Implantation

Attempt to remove the placenta by usual methods.

Excess traction on cord may cause cord tear or uterine inversion.

If placenta retained for >30 minutes, this may be caused by abnormal placental implantation.

Abnormal implantation defined. Caused by missing or defective decidua. Placenta Accreta: Placenta adherent to

myometrium. Placenta Increta: myometrial invasion. Placenta Percreta: penetration of

myometrium to or beyond serosa. These only bleed when manual removal

attempted.

Removal of Abnormal Placenta

Oxytocin 10U in 20cc of NS placed in clamped umbilical vein.

If this fails, get OB assistance. Check Hct, type & cross 2-4 u. Two large bore IVs. Anesthesia support.

Removal of Abnormal Placenta

Relax uterus with halothane general anesthetic and subcutaneous terbutaline.

Bleeding will increase dramatically. With fingertips, identify cleavage plane

between placenta and uterus. Keep placenta intact. Remove all of the placenta.

Removal of Abnormal Placenta

If successful, reverse uterine atony with oxytocin, Methergine, Hemabate.

Consider surgical set-up prior to separation. If manual removal not successful, large

blunt curettage or suction catheter, with high risk of perforation.

Consider prophylactic antibiotics.

Trauma (3rd “T”)

Episiotomy Hematoma Uterine inversion Uterine rupture

Uterine Inversion

Rare: ~1/2000 deliveries. Causes include: Excessive traction on cord. Fundal pressure. Uterine atony.

Uterine Inversion

Blue-gray mass protruding from vagina. Copious bleeding. Hypotension worsened by vaso-vagal

reaction. Consider atropine 0.5mg IV if bradycardia is severe.

High morbidity and some mortality seen: get help and act rapidly.

Uterine Inversion

Push center of uterus with three fingers into abdominal cavity.

Need to replace the uterus before cervical contraction ring develops.

Otherwise, will need to use MgSO4, tocolytics, anesthesia, and treatment of massive hemorrhage.

When completed, treat uterine atony.

Uterine Rupture

Rare: 0.04% of deliveries. Risk factors include: Prior C/S: up to 1.7% of these deliveries. Prior uterine surgery. Hyperstimulation with oxytocin. Trauma. Parity > 4.

Uterine Rupture

Risk factors include: Epidural. Placental abruption. Forceps delivery (especially mid forceps). Breech version or extraction.

Uterine Rupture

Sometimes found incidentally. During routine exam of uterus. Small dehiscence, less than 2cm. Not bleeding. Not painful. Can be followed expectantly.

Uterine Rupture before delivery

Vaginal bleeding. Abdominal tenderness. Maternal tachycardia. Abnormal fetal heart rate tracing. Cessation of uterine contractions.

Uterine Rupture after delivery

May be found on routine exam. Hypotension more than expected with

apparent blood loss.

Uterine Rupture

When recognized, get help. ABCs. IV fluids. Surgical correction.

Birth Trauma

Lacerations of birth tract not rare: causes post partum hemorrhage in 1/150 deliveries.

Birth Trauma Risk factors include: Instrumented deliveries. Primiparity. Pre-eclampsia. Multiple gestation. Vulvovaginal varicosities. Prolonged second stage. Clotting abnormalities.

Birth Trauma

Repair lacerations quickly. Place initial suture above the apex of

laceration to control retracted arteries.

Birth Trauma: Hematomas Hematomas less than 3cm in diameter can

be observed expectantly. If larger, incision and evacuation of clot is

necessary. Irrigate and ligate bleeding vessels. With diffuse oozing, perform layered

closure to eliminate dead space. Consider prophylactic antibiotics.

Thrombin (4th “T”)

Coagulopathies are rare. Suspect if oozing from puncture sites noted. Work up with platelets, PT, PTT, fibrinogen

level, fibrin split products, and possibly antithrombin III.

Prevention?

Some evidence supports use of oxytocin after delivery of anterior shoulder, in umbilical vein or IV.

Summary: remember 4 Ts

Tone Tissue Trauma Thrombin

Summary: remember 4 Ts

“TONE” Rule out Uterine

Atony

Palpate fundus. Massage uterus. Oxytocin 40U/L @

250cc / h. Methergine one amp

IM (not in hypertensives)

Hemabate IM q 15min

Summary: remember 4 Ts

“Tissue” R/O retained placenta

Inspect placenta for missing cotyledons.

Explore uterus. Treat abnormal

implantation.

Summary: remember 4 Ts

“TRAUMA” R/o cervical or vaginal

lacerations.

Obtain good exposure. Inspect cervix and

vagina. Worry about slow

bleeders. Treat hematomas.

Summary: remember 4 Ts

“THROMBIN” Check labs if suspicious.