7/25/2019 Jalava HLO
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Emerging Infectious Diseases Vol. 7, No. 6, November-December
2001, pp. 1036-38.
Dispatch
A Cultured Strain of "Helicobacter heilmannii," a Human
Gastric
Pathogen, Identified asH. bizzozeronii
: Evidence forZoonotic Potential of Helicobacter
Katri Jalava,* Stephen L.W. On, Clare S. Harrington, Leif P.
Andersen, ar!a"
Liisa H#nninen,* and Peter $anda%%e&
*Faculty of Veterinary Medicine, University of Helsinki, Finland
!"anis# Veterinary
$a%oratory, &o'en#a(en, "en)ark +i(s#os'italet,
&o'en#a(en, "en)ark andUniversity of #ent, #ent, el(iu)
We compared the characteristics of a cultured human
"Helicobacter heilmannii" isolate with thoseof other helicobacters
found in animals. Phenotypic, protein profile, 16S rDNA seuence,
andDNA!DNA hybridiation analyses identified the human strain as H.
bizzozeronii, a speciesfreuently found in do#s. $hus, H.
bizzozeroniimay ha%e oonotic potential.
/#e i)'ortance ofelicobacter p!loriin #u)an (astric disease is
ell reco(nied 21.
4fter its initial isolation, a distinctive, ti(#tly coiled
or(anis) as also o%served in so)e#u)an (astritis cases 25. 4lt#ou(#
t#ese or(anis)s could not %e isolated in vitro 23,,
t#ey ere desi(nated as 7"astrospirillum #ominis7 on t#e %asis of
)or'#olo(y and
ecolo(ic nic#e 2, and later as 7. #eilmannii7 on t#e %asis of 16
r+94 (ene se:uenceanalysis. "ifferences in 16 r+94 (ene se:uences
#ave alloed to ty'es to %e defined
for $. #eilmannii,7 #ic# accounts for 0.5; to ; of #u)an
(astritis cases 2-10. 4s a conse:uence, t#e 'ossi%ility of
oonoticinfection #as %een considered 23,10,11. /#ree distinct
s'ecies rese)%lin( 7.#eilmannii7 #ave %een isolated fro) cats or
do(s, na)ely. felis, . bi%%o%eronii,and.
salomonis210. /#e 'rovisional na)e $&an'i'atusH. suis7 #as
%een 'ro'osed for t#e 'i(
or(anis) 28. Hoever, critical co)'arison of strains fro) eac# of
t#ese sources #as not%een 'ossi%le %ecause fe orkers #ave o%tained
cultures of #u)an strains. /o our
knoled(e, only one 7. #eilmannii7 strain #as %een cultured fro)
#u)an tissue 26.
?e 'resent t#e results of a 'oly'#asic identification analysis
t#at confir)s t#is #u)an
7. #eilmannii7 isolate as. bi%%o%eronii, and e discuss t#e
'u%lic #ealt# i)'licationsof t#is findin(.
The Stud
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