ENDOCRINE AND METABOLIC SYSTEM

( 7 SKS )

Dr. A. Makbul Aman

Sistem Endokrin dan MetabolismeFakultas Kedokteran Universitas

Hasanuddin

What is the Endocrine System ?

1. A chemical messenger or hormone produced by an organ is released into circulation to produce an effect on a distant target organ

2. An integrated network of multiple organs derived from different embryologic origins that release hormone ranging from small peptides to glycoprotein which exert their effects either in neighboring or distant target cells

3. Three basic component make up the core of the endocrine system :a. Endocrine glandb. Hormonec. Target organs

Definitions• Endocrinology- the study of hormone and

glandular abnormalities- diabetes, thyroid problems, and circus performers

• Hormones- biologically active substances secreted by glands. – Endocrine- hormones that have a biological

effect far away. – Paracrine - hormones that have a biological

effect nearby. – Autocrine - hormones that have a local

effect

The endocrine organ are located throughout the body

Some of the key functions of EM System include :

• Regulation of sodium and water balance and control of blood volume and pressure

• Regulation of calsium and phosfat balance to preserve extracellular fluid concentrations required for cell membrane integrity and intracellular signaling.

• Regulation of energy balance and control of fuel mobilization, utilization and storage to ensure that cellular metabolic demand are met.

• Coordination of the host hemodynamic and metabolic counterregulatory responses to stress

• Regulatory of reproduction, development, growth and senescence.

Is to coordinate and integrate cellular activity within the whole body by regulating cellular and organ function throughout life and maintain homeostasis.

Hemodynamic and metabolic counterregulatory response to stress

MODUL

1. Diabetes Mellitus : 1.1. Type 1 Diabetes 1.2. Screening and diagnosis type 2 DM

1.3. IFG/IGT 1.4. Coma : KAD and HONC, Lactic acidosis 1.5. GDM 1.6. Diabetic Foot 1.7. DM and Its Related diseases 1.8. Hypoglycemia 1.9. Micro and Macrovascular complications 1.10. Neuropathy diabetic

2. Modul Obesity and MetSyn 2.1. Obesity and metabolic diseases 2.2. PCOS 2.3. Lipidology

2.4. The ADIPOSE Tissue

3. MODUL INTEGRATED CASES 3.1. Steroids and its related to metabolic and endocrine diseases 3.2. Osteoporosis 3.3. Cardio-Metabolic Diseases

4. THYROID

4.1. Grave’s Disease 4.2. Hypothyroidism ( Hashimoto, thyroiditis etc ) 4.3. Periodic paralysis thyrotoxicosis ( PPT) 4.4. Hypo and hyperthyroid in pregnancy 4.5. Thyroid Storm 4.6. Thyroid Nodule 4.7. IDD5. MODUL PARATHYROID :

5.1. Hypocalcemic Crisis 5.2. Hypercalcemia

5.3. Metabolic bone disease

6. MODUL PITUITARY 6.1. Acromegaly / Gigantism 6.2. SIADH 6.3. Hyperprolactinemia 6.4. Diabetes Insipidus 6.5. Empty Sella Syndrome

6.6. Cushing disease7. ADRENAL :

7.1. Addison disease 7.2. Cohn Syndrome 7.3. Adrenal crisis 7.4. Feochromacytoma

8. Modul Paediatric Endocrinology8.1. Pediatric growth and development8.2. Disease of pituitary in child and adolescent8.3. Hypo and hyperthiroidism in child8.4. Adrenal diseases in child8.5. Sexual dysfunction in child

Acromegaly

Cushing’s Syndrome

Topic of CSL

1. Thyroid Examination2. Antrhopometric3. Insulin Injection

Thyroid examination

The insulin injections

Topic of PBL1. Weight loss :

a. Graves’ Diseasesb. Diabetes Mellitus

2. Polyuria :a. Diabetes Insipidus

3. Obesity :a. Metsynb. Acromegaly

EVALUATION1. Praktikum : 10 %2. CSL : 10 %3. Tutorial/PBL : 15 %4. Ujian teori/Final : 65 %

NBL : 55

Time Allocation (1 )Items Lecture Prac. PBL CSLAnatomy 2 -

Histology 2 3Biochemystry 3 3

Physiology 2 -

Clin.Path 2 3

Pathology 2 3

Nutrition 4 - 6

Pharmacol 3 -

Radiology 2

Time Allocation (2 )Items Lecture Prac. PBL CSLPaediactic 10 -

Int.Med 22 - 12

Opthalmolol 2

Neurologyst 2

Obstetric 2

Others 4

T O T A L 65 12 12 12

The Dream TeamProf. Dr. John MF Adam Dr. Jumraeni TProf.Dr. Harsinen Sanusi Dr. Harfiah DjProf.Dr.Irawan Yusuf, PhD Dr. Habibah,SProf. DR.dr. Suryani A Dr. Agus P. SamboProf.DR.dr. Nur Puji A Dr Arthur KoswandiDR.Dr. Satriono Dr. Rosdiana NatsirDr. A. Makbul Aman Dr. Husaini UmarDr. Truly Dasril Dr. Robert SDr. Yosephin TDr. Adriani Baji