Welcome to Biology 140Welcome to Biology 140Fundamentals of MicrobiologyFundamentals of Microbiology

““Introduction to the biology of bacterial and Introduction to the biology of bacterial and archaeal organisms. Topics include microbial archaeal organisms. Topics include microbial cell structure and function, methods of cell structure and function, methods of cultivation, genetics, phylogeny and cultivation, genetics, phylogeny and taxonomy, and metabolic and genetic taxonomy, and metabolic and genetic diversity.diversity.” ”

Other Microbiology Courses at Other Microbiology Courses at WaterlooWaterloo

• Biology 241 – Introduction to Applied MicrobiologyBiology 241 – Introduction to Applied Microbiology• Biology 345 – Microorganisms in FoodsBiology 345 – Microorganisms in Foods• Biology 348L – Laboratory Methods in MicrobiologyBiology 348L – Laboratory Methods in Microbiology• Biology 431 – Bacterial Molecular GeneticsBiology 431 – Bacterial Molecular Genetics• Biology 442 – VirologyBiology 442 – Virology• Biology 443 – Fermentation BiotechnologyBiology 443 – Fermentation Biotechnology• Biology 444 – Microorganisms and DiseaseBiology 444 – Microorganisms and Disease• Biology 446 – Microbial EcologyBiology 446 – Microbial Ecology• Biology 447 – Environmental MicrobiologyBiology 447 – Environmental Microbiology• Biology 448 – Microbial Physiology and BiochemistryBiology 448 – Microbial Physiology and Biochemistry• Biology 449 – Public Health Microbiology (beginning W06)Biology 449 – Public Health Microbiology (beginning W06)• Biology 474 – BioprocessingBiology 474 – Bioprocessing• Biology 475 – Current Topics in Applied MicrobiologyBiology 475 – Current Topics in Applied Microbiology

Biology 140: Fundamentals of MicrobiologyBiology 140: Fundamentals of Microbiology

Dr. Trevor C. Charles, B1 Rm 377Cext. 5606, tcharles@uwaterloo.ca

Textbook:Textbook: Madigan, M.T., Martinko, J.M. 2006. Brock Biology of Microorganisms, 11th ed. Prentice Hall. You can also use the 10th edition.• available at UW bookstore

Biol 140LBiol 140L (related lab course):(related lab course): begins 2nd week of classes Instructor:Instructor: Dr. C.L. Duxbury, ESC Rm 357F, ext. 6450, cduxbury@uwaterloo.caLab ManualLab Manual – available at UW bookstore• WHMIS required; lab coat required• Biol 140L exam (1 h) will be scheduled by the Registrar

Biol 140 web pageBiol 140 web page: accessible from UW home page or Science home page• notes, Powerpoint presentation files, course information

Course marks:Course marks:midterm exam: 30%final exam: 70%

100%

midterm exam:midterm exam: Thursday Oct 26th, 5:45 – 6:45 p.m. (tentative until rooms are scheduled)final exam: final exam: will be scheduled by the Registrar (2.5 h)• exam format will be multiple choice, matching, true-or-false questions

Supplementary resources:Supplementary resources: On Reserve, Davis LibraryPrescott, L.M., Harley, J.P., Klein, D.A. 2005. Microbiology, 6th ed. McGraw-Hill.

Salyers, A.A., Whitt, D.D. 2001. Microbiology: diversity, disease and the environment. Fitzgerald Science Press.

Perry, J.J., Staley, J.T., Lory, S. 2002. Microbial Life. Sinauer Associates.

• also a copy of Madigan et al.

Lecture 1Lecture 1

• 1.1 Microbiology1.1 Microbiology• 1.2 Microorganisms as Cells1.2 Microorganisms as Cells• 1.3 Microorganism and Their Natural 1.3 Microorganism and Their Natural

EnvironmentsEnvironments• 1.4 The Impact of Microorganisms on 1.4 The Impact of Microorganisms on

HumansHumans

What is Microbiology?What is Microbiology?

• The science of microorganisms (very small, The science of microorganisms (very small, unicellular organisms)unicellular organisms)

• The discipline is just over a century oldThe discipline is just over a century old• Has given rise to molecular biology and Has given rise to molecular biology and

biotechnologybiotechnology

What are Microbes?What are Microbes?

Root Nodule

Bacteroids within Root Nodule

Why study Microbiology?Why study Microbiology?

• Microorganisms were the first life on earthMicroorganisms were the first life on earth• Microorganisms created the biosphere that allowed Microorganisms created the biosphere that allowed

multicellular organisms to evolvemulticellular organisms to evolve• Multicellular organisms evolved from Multicellular organisms evolved from

microorganismsmicroorganisms• >50% of the biomass on earth is comprised of >50% of the biomass on earth is comprised of

microorganismsmicroorganisms• Microorganisms will be on earth foreverMicroorganisms will be on earth forever

4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0

Billion Years Ago

Formation of O2

atmosphereCyanobacterial microfossils(oxygenic photosynthesis)Earth formed

First microorganisms?

algae,marine invertebrates

insectsmammals

No free O2

Reducing environment

Why study Microbiology?Why study Microbiology?

• Our understanding of life has arisen largely Our understanding of life has arisen largely from studies of microorganisms from studies of microorganisms (biochemistry and genetics)(biochemistry and genetics)

• Studies of microorganisms continue to Studies of microorganisms continue to contribute to fundamental knowledge of life contribute to fundamental knowledge of life processesprocesses

• We still know very little about the We still know very little about the microorganisms that are present on Earthmicroorganisms that are present on Earth

Why study Microbiology?Why study Microbiology?

• HealthHealth• AgricultureAgriculture• FoodFood• EnvironmentEnvironment

impact of microorganisms on human affairs:impact of microorganisms on human affairs:

Infectious diseases are no longer the leading cause of death in North America, due to the Infectious diseases are no longer the leading cause of death in North America, due to the development and use of antimicrobial agents, and improved sanitary practices.development and use of antimicrobial agents, and improved sanitary practices.