Interwaved Modulated Radio Frequency€¦ · Body & Face Solutions 9 Meso abrasion removes stratum corneum => ~70 % more permeable skin Meso poration allows an intercellular penetration

Concept

Interwaved Modulated Radio Frequency

BROCHURE 12P MESOSENSE 13/03/07 17:04 Page 1


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Aimed at cosmetic medicine professionals. It produces the same effects astraditional mesotheraphy, without needles, without pain and withoutcontraindications.

The skin acts as a natural barrier against the entry of foreign substances intoorganism. In order for a substance applied to the skin to be absorbed trans-epidermally, it must pass the corneous stratum. This is what is achieved withthe Meso Sense electroporation equipment.

RR..FF..MM.. :: This is a system of Electroporation by Frequency Modalation Radio(I.M.R.F.)

It is an alternative to traditional mesotherapy, without needles, without painand extremely efficient and reliable, as it enables us to introduce the desiredmedication to the depth required by each treatment. It does not have anysecondary effects, either, and it can be used in different therapies: pain,obesity, flaccidity, cellulite…

HHooww ddooeess II..RR..MM..FF.. ssyysstteemm wwoorrkkss??

The system emits electronic impulses by means of a high frequency and lowintensity mechanism. These act by permeabilising the cellular membraneand easily and quickly permitting the introduction of active principlesdirectly to the cell (from 0.25 to 1.50 grams per minute), thus speeding upthe duration of the patient’s treatment.

HHooww ddooeess MMeessoo SSeennssee aacctt aatt tthhee cceellll lleevveell??

It causes a state of biological stress, altering the membrane potential, causing an electroporation of the bilayer lipids, giving rise to the formationof pores and openings in the protein channels. This I.R.M.F. phenomenon isachieved at the time of the electromagnetic wave impulse and it is reversible,because this is by pulses and not maintained, with which the cell returns toits state of normality. The cell recuperates its integrity when the membranepotential is normalized due to a so-called “on-off” mechanism.


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SSuubbssttaanncceess ccaann ppaassss tthhrroouugghh tthhee ttiissssuueess::

• By transcellular way: This increases the permeability of the cellular membrane.

• By interstitial way: Through the lipids of the intercellular space.

WWiitthh tthhee MMeessoo SSeennssee -- II..MM..RR..FF.. eelleeccttrrooppoorraattiioonn ssyysstteemm ssuubbssttaanncceess ppaassss tthhrroouugghh tthhee sskkiinn::

• By transepidermal way: The substance crosses the skin as it overcomes the barrier of the corneous layer.

• By pilosebaceous way: The absorption takes place through the epithelial cells of the sebaceous glands.This is used by hydrolipidic and lipidic products.

• By sudoriparous way: At cell level of the sudoriparous glands. Ionic products use this.

AAddvvaannttaaggeess oovveerr ootthheerr ttrraannssddeerrmmaall ttrraannssppoorrtt tteecchhnniiqquueess oorr ssyysstteemmss::

• There is no electronic contact with the patient. So there is no risk of chemical burns, muscular fascicula-tion, pain or inflammation.

• It is not invasive.

• It has no return electrode (ground plate).

• It is not contraindicated in prosthesis.

• There is no molecular ionization of the transported substances.

• It is valid for ionic, non-ionic and lipidic substances. .

• The speed of transcutaneous penetration of the hydrolipid products is approximately 1 gram per 60seconds.

• It does not require any conductor gel.

• It has no secondary effects.

• Practical, transportable and easy to handle.

• It introduces substances of any molecular weight.

IInnddiiccaatteedd iinn::

• Obesity • Cellulite • Flaccidity • Facial treatments • Stretch marks

Electroporation by radio-frequency is a veryreliable techniques which can be adapted tomultiple therapies and opens up the way tonumerous possibilities.

CCoonnttrraaiinnddiiccaattiioonnss::

• Patients with pacemakers • Pregnant women • Severe acne • Epileptic patients


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Clearing up concepts

WWhhyy ddoo wwee ssaayy tthhaatt II..MM..RR..FF.. ssyysstteemm iiss nnoott aann iioonnttoopphhoorreessiiss??

Iontophoresis is the transdermal vehicule for small ionic agents, but in case, for example, of rosehip, colla-gen, etc, they are not normally introduced through iontophoresis, because their molecules are too big.

WWhhyy ddoo wwee ssaayy tthhaatt II..MM..RR..FF.. ssyysstteemm iiss nnoott aa pphhoonnoopphhoorreessiiss??

Phonophoresis is the transdermal vehicle for small agents that require a conductor gel. Electroporationdoes not need this.

WWhhyy ddoo wwee ssaayy tthhaatt II..MM..RR..FF.. ssyysstteemm iiss nnoott aa mmeessootthheerraapphhyy??

Traditional mesotherapy required injecting with a needle and it consists of the transdermal penetration of any ionic or non-ionic agent. However, it does not guarantee intracellular penetration and causes pain,ecchymosis, oedemas, etc. That is why we say that electroporation is not mesotherapy. Electroporationproduces the same effects as traditional mesotheraphy, but without contraindications.

WWhhaatt iiss tthhee II..MM..RR..FF.. ssyysstteemm,, tthheenn??

I.M.R.F. is the transdermal penetration of any ionic or non-ionic active principle with molecules of anysize, hydro or liposoluble, transported by a liposomed complex.

I.M.R.F. is a revolutionary technique that is able to increase the cellular capturing power, as it mana-ges to facilitate the passing of substances through the cellular membrane. Thus, we will induce theopening of two channels of the cellular membrane (protein channels) and pores in the cell whichbecome more receptive to the application of substances.

We also use the aqueous channels, known as 2Aquaporines as a cellular penetration way. Thesewere discovered by the North American doctor, Peter Agree and Roderick Mackinnon, who wereawarded the Nobel Prize in Chemistry in 2003. The technique that carries out the penetration ofsubstances through the opening of the aqueous channels, induced by the application of an electro-magnetic wave, is known as I.M.R.F.

That new technologicals concept appeared almost five years ago, when Dr. Praunist discovered thephenomenon of .I.M.R.F. It refers to the transitory inversion of the rest potential of the cellular mem-brane, induced by the emission of an electromagnetic wave (EMW) with special characteristics.

B o d y & F a c e S o l u t i o n s


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TTeecchhnniiccaall cchhaarraacctteerriissttiiccss::

• Power supply 220 - 240 V.A.C.• Consumption 30 W• Wave Interweaved modulated• Transit speed 0,25 to 1,50 grams per minute• Timing Digital, minutes, seconds• Indicator Digital transit speed• Energy control By analogue regulation• Applicator sensor Thermoplastic material 10 kv/mm



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Instructions of the way of use

FFrroonntt PPaanneell

11.. Connect the machine power cable to the mains.

22.. Connect the switch situated at the back of the machine. The power light will come on.

33.. Connect the facial head (small) on the Face connector (red) to the corporal head (large) on the Bodyconnector (black), depending on the treatment to be carried out.

44.. Choose the penetration level by pressing mode:

Slow: superficial level (mesotherapy 4 mm. approx.)

Fast: deep level

55.. Programming operation time

Upward arrow: raise number

EExxaammppllee:: 1155 mmiinnuutteess pprrooggrraammmmee

1. Press upward arrow until 5

2. Press double arrows (there is a point to the right of the number)

3. Press upward arrow until 1

The time is now set.

66.. To start the treatment, press On. The Emitting light will come on.

• If you want ttoo ppaauussee, press Off

• TToo ccoonnttiinnuuee, press On once again.

• A beep will indicate that the programmed time has finished.

77.. Grams screen:

Indicates the approximate use of product in grams. This quantity depends on the density of the productused.

Note: The heads of the equipment are the most delicate part of the machine. We advise storing them aftertreatment in a suitable place, to avoid rubbing or falling. Do not use alcohol or products with alcoholiccontent.


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No needle mesotherapy

II..MM..RR..FF.. PPoorraattiioonnInterwaved modulated radio frequency

SSttrraattuumm ccoorrnneeuumm lliimmiittss sskkiinn ppeerrmmeeaabbiilliittyy

Permeable Keratinocytes

Permeable Dermis

No efficient penetration through stratum corneum

Topical Meso mixtures





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MMeessoo aabbrraassiioonn rreemmoovveess ssttrraattuumm ccoorrnneeuumm ==>> ~~7700 %% mmoorree ppeerrmmeeaabbllee sskkiinn

MMeessoo ppoorraattiioonn aalllloowwss aann iinntteerrcceelllluullaarr ppeenneettrraattiioonn ooff aaccttiivvee pprroodduuccttss

Mesotherapy without needles

Allowing a deep local action from basal layer to reticulary dermis and hypodermis


Stratum Corneum Soft Abrasion

Electroporation

Permeable Dermis


Permeable Dermis







Even transepidermalpenetration

Deeper dermal penetration


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No needle mesotherapy

PPrroottooccooll MMeessoo--aabbrraassiioonn

11.. Skin disinfection

22.. Slow - soft - gentle - superficial

Sand paper abrasion (www.skintech.info)

No one blood drop should appear => Not painful abrasion

Only just remove stratum corneum

MMeessoo-- II..MM..RR..FF..

33.. Apply the mixture directly on the skin cover with a plastic sheet (avoids evaporation)

Deep penetration immediately begins

44.. Use electroporation during few minutes

Penetration enhances +++

CCoocckkttaaiill eexxaammpplleessCCeelllluulliittee ccoocckkttaaiill

• 5 cc Silorgamine

• 1 cc Melirutol

• 1 cc Puretinol

• 1 cc K-bromine 20

• 2 cc Centellasial

MMeessoo lliifftt ccoocckkttaaiill

• 5 cc DM lift

• 2.5 cc Hyalift

• 1 cc Purascorbol

• 1 cc Puretinol

MMeessoo mmeellaassmmaa ccoocckkttaaiill

• 1 cc Purascorbol

• 1 cc GSH

• 1 cc Dexenol

• 1 cc Taurinox



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Before treatment After 1st treatment After 2nd treatment

Before treatment After 1st treatment After 4th treatment

Results


Aesthetic Dermal, S.L.C/Falconera, 9 - 17487 Empuriabrava (Girona) - Spain

Tel. 34 972 45 37 77 - Fax 34 972 45 39 [email protected]

• Mesolift

• Mesoglow

• Mesofat

• Meso Cellulitis

• Meso Hair

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Interwaved Modulated Radio Frequency€¦ · Body & Face Solutions 9 Meso abrasion removes stratum corneum => ~70 % more permeable skin Meso poration allows an intercellular penetration