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Insulin Production. Ultrafiltration Process Andrea Adams 1 April, 2004 CHEE 450. Unit Specifications – Givens. Insulin: 5700~5800 Da Polysulfone/Polyethersulfone membrane Rejection Coefficient 100% Concentrate Insulin x 10. Theory – Operation Principles. - PowerPoint PPT Presentation
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Insulin Production
Ultrafiltration Process
Andrea Adams
1 April, 2004
CHEE 450
Unit Specifications – Givens
Insulin: 5700~5800 Da Polysulfone/Polyethersulfone membrane Rejection Coefficient 100% Concentrate Insulin x 10
Inlet (kg/batch) Oulet (kg/batch)
Acetonitrile 210 14
Insulin 192 191
WFI 5053 342
Theory – Operation Principles
Pressure driven membrane separation process
Membrane configuration is cross-flow
Millipore
Hardware Design
Millipore
Visuals
1890-3785 L/day7570-15140 L/day
Filtertech
Membrane
Polysulfone Produced in large quantities so tends to be cheaper
Polyethersulfone PES theoretically has slight advantage over PS More hydrophilic
Cellulose Acetate Low chemical resistance; sensitivity to biodegradation Difficult to clean; must be in constant presence of Cl
Flows
Perry’s
Assumptions Made
Density of inlet stream similar to H2O
1 batch/day 24 h production cycle 316 L mini-batches Flux = 50 L.m-2.h-1
Suppliers
Reverse Osmosis of South Florida (Florida)
Omexell, Inc. (Alabama) Aquafilter, Inc. (Maryland) Southwest Water Systems Co.
(Oklahoma) Uniexcel Agencies & Services
Pvt. Ltd. (India) Nilgiris Chemical Stoneware
Company (India) GEA Filtration (Wisconsin) Culligan International Co.
(Illinois)
Pollard Industries, LLC (Louisiana) Ionics (Massachusetts) Saborn Technologies
(Massachusetts) Berghof Filtration (Germany) Applied Membranes (California) Hydranautics (California) inge AG (Illinois) Koch Membrane Systems (USA) Luxx Ultra-Tech NORIT Membrane Technology BV
(Netherlands) PCI Membrane Systems Ltd. (UK)
Design Considerations
Millipore process specification data entry NMWL (kDa) Width (cm) Stack Design Filtration Area (m2) Height (cm) Length (cm) Filter Material Configuration Diameter (cm)
Sizing
316 L capacity Max. operating pressure: 5 bar Operating conditions: pH 1-14 Dimensions: 97 x 48 x 89 cm Weight: 580 kg Fine Screen: 12-15 L.min-1 per 2.8 m2 cassette Need 20 m2 filtration area, 7 cassettes $147,800
Pall Corporation
Process Alternatives
Spiral Wound oriented Ultrafiltration Hollow Fiber oriented Ultrafiltration Reverse Osmosis
Retains too much Microfiltration
Retains too little Diafiltration