8
Please see Important Safety Information throughout. Click here for Prescribing Information. THE DIFFERENCES BETWEEN HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. Would your patients on human premix insulin benefit from an analog, too? Indications and Usage • NovoLog ® Mix 70/30 is an insulin analog indicated to improve glycemic control in patients with diabetes mellitus. Important Limitations of Use • In premix insulins, such as NovoLog ® Mix 70/30, the proportions of rapid-acting and long-acting insulins are fixed and do not allow for basal versus prandial dose adjustments. Important Safety Information Contraindications • NovoLog ® Mix 70/30 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog ® Mix 70/30 or one of its excipients. eg, NOVOLIN ® 70/30 VS HUMAN premix insulin NOVOLOG ® MIX 70/30 Premix insulin ANALOG

HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Embed Size (px)

Citation preview

Page 1: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Please see Important Safety Information throughout. Click here for Prescribing Information.

THE DIFFERENCES BETWEENHUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG

Physicians often prescribe analog basal and bolus insulin. Would your patients on human premix

insulin benefit from an analog, too?

Indications and Usage• NovoLog® Mix 70/30 is an insulin analog indicated to improve glycemic

control in patients with diabetes mellitus.

Important Limitations of Use• In premix insulins, such as NovoLog® Mix 70/30, the proportions of

rapid-acting and long-acting insulins are fixed and do not allow for basal versus prandial dose adjustments.

Important Safety InformationContraindications• NovoLog® Mix 70/30 is contraindicated during episodes of hypoglycemia

and in patients hypersensitive to NovoLog® Mix 70/30 or one of its excipients.

eg, NOVOLIN® 70/30

VS

HUMAN premix insulin

NOVOLOG® MIX 70/30

Premix insulin

ANALOG

Page 2: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Explore the differences when choosing a premix formulation

Human premix insulineg, NOVOLIN® 70/30

Premix insulin analogNOVOLOG® MIX 70/30

a NovoLog® Mix 70/30 has a flexible dosing approach that allows patients with type 2 diabetes to dose within 15 minutes before or after meal initiation vs 30 minutes before meals required with human premix insulin.

b Intended as a guide. Lower acquisition costs alone do not necessarily reflect a cost advantage in the outcome of the condition treated because there are other variables that affect relative costs. Formulary status is subject to change.

2Please see Important Safety Information throughout. Click here for Prescribing Information.

No NPH insulin

More closely matches the body’s

physiologic insulin profile

Available in a discreet FlexPen®

Flexible dosing: dosed within 15 minutes before or after starting a meal in patients with

type 2 diabetesa

Same co-pay on most managed

care plansb

Page 3: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

NovoLog® Mix 70/30 FlexPen®

NovoLog® Mix 70/30 FlexPen®

Human premix insulin(30 minutes before)

Important Safety Information (cont’d)Warnings and Precautions• Never Share a NovoLog® Mix 70/30 FlexPen® Between

Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens.

• Administration: NovoLog® Mix 70/30 should not be mixed with any other insulin product, administered intravenously, or used in insulin infusion pumps. NovoLog® Mix 70/30 has a faster onset of action than human insulin premix 70/30 and should be dosed within 15 minutes before meal initiation for patients with type 1 diabetes. For patients with type 2 diabetes, dosing should occur within 15 minutes before or after meal initiation.

Patients may benefit from an insulin analog that more closely matches the body’s physiologic insulin profile

0 2 4 6 8 10 12 14 16 18 20 22 24

Time (hours)

Phar

mac

okin

etic

s(s

erum

insu

lin p

mol

/L)

200

150

100

50

0

NovoLog® Mix 70/30

Human premix 70/30

FASTER ONSET OF ACTIONAND HIGHER PEAK

NO SECOND PEAK

NOVOLOG® MIX 70/30 VS HUMAN PREMIX 70/30 PHARMACOKINETICS1

Flexible dosing vs human premix insulin

NovoLog® Mix 70/30 should be dosed within 15 minutes before or after meal initiation in patients with type 2 diabetes vs 30 minutes before a meal for human premix insulin (eg, Novolin® 70/30).

Single-center, randomized, double-blind, 24-hour, crossover trial in 24 healthy male volunteers receiving 1 injection of NovoLog® Mix 70/30 or human premix 70/30 0.3 units/kg. Serum insulin concentrations were assayed every 30 minutes. Adapted from Weyer et al, 1997.1

3

Page 4: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

In the IMPROVE™ study, converting patients from human premix insulin to NovoLog® Mix 70/30 provided2,a:

GLYCEMIC CONTROL

Convert patients who may benefit from a premix insulin analog

Glycemic control and safety

Results from patients who completed the IMPROVE™ study who were previously treated with human premix ± oral antidiabetic drug (OAD) therapy and had A1C values available at baseline and final visit. The IMPROVE™ study was a multinational, open-label, nonrandomized, 26-week, observational study that evaluated the safety and efficacy of NovoLog® Mix 70/30 in patients with type 2 diabetes, n=3856.2

Simple unit-to-unit conversion

1 unit Human premix 70/30 NovoLog® Mix 70/30

4

A 92% reduction in major hypoglycemic events was also observed (0.36 to 0.03 events/patient/year; values based on patient recall, P<0.0001)2A1C reduction1

(P<0.0001)Reduction in major hypoglycemic events1

(P<0.0001)

A1C

9.21%

7.37%

0.36

0.03

Maj

or h

ypog

lyce

mic

eve

nts/

patie

nt/y

ear

(val

ues

base

d on

pat

ient

rec

all)

Please see Important Safety Information throughout. Click here for Prescribing Information.

Page 5: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Important Safety Information (cont’d)Warnings and Precautions• Hypoglycemia: Hypoglycemia is the most common adverse

effect of insulin therapy. The timing of hypoglycemia may reflect the time-action profile of the insulin formulation. Glucose monitoring is recommended for all patients with diabetes. Any change of insulin dose should be made cautiously and only under medical supervision.

• Hypokalemia: Insulin, particularly when given in settings of poor glycemic control, can cause hypokalemia. Use caution in patients predisposed to hypokalemia.

Broad access

More units, same co-pay

One box of NovoLog® Mix 70/30 FlexPen®

provides 50% more insulin than human premix insulin in a vial for the same co-pay on most managed care plansd

NovoLog® Mix 70/30 is covered for a majority of managed care patients nationwide3,a-c

a Intended as a guide. Lower acquisition costs alone do not necessarily reflect a cost advantage in the outcome of the condition treated because there are other variables that affect relative costs. Formulary status is subject to change.

b Managed care plans only. Does not include Medicaid and Medicare Part D. Multiple products within the same therapeutic class may be considered preferred and on the same tier.

c Formulary data are provided by Fingertip Formulary® and are current as of January 2015. Because formularies do change and many health plans offer more than one formulary, please check directly with the health plan to confirm coverage for individual patients. © 2015 Fingertip Formulary. All rights reserved.

dOne box of FlexPen® equals 1500 units vs 1 vial with 1000 units.

Visit novologmix70-30pro.com and access the “Coverage and Savings” tab to check formulary coverage for your patients.

5

50%

1000 units 1500 units

x5

Page 6: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Offer patients a discreet delivery device

NovoLog® Mix 70/30 FlexPen®—the world’s #1 selling prefilled insulin pena

With NovoFine® Plus needles, our shortest and thinnest needles available

Proven accuracy4

Requires low injection force4

Lasts up to 14 days without refrigeration and should not be refrigerated once in use

SuperFlow Technology™—designed to enhance flow rates and reduce dosage force

Ultrastrong—designed to resist bending or breaking

Universal—fits all currently available insulin pens

Discreet, prefilled, dial-a-dose insulin pen

aIMS Health Inc. IMS Global MIDAS (3 years ending July 2014).

6

Needles are sold separately and may require a prescription in some states.

Please see Important Safety Information throughout. Click here for Prescribing Information.

Page 7: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

Support patients in managing their diabetes

With NovoLog® Mix 70/30, your patients benefit from a variety of support resources, including:

Patient BrochureExplains the benefits of NovoLog® Mix 70/30 and how to use the FlexPen® device for your patients.

Cornerstones4Care®

Free, personalized, and award-winning support through the Cornerstones4Care® program.

Patient Active Learning (PAL) KitFeatures both printed and audio instructions to help patients get off to a good start (available through Cornerstones4Care®).

Novo Nordisk Instant Savings CardProduct savings through the Novo Nordisk Instant Savings Card. Restrictions apply; see card for details.

To learn more about these resources, visit novologmix70-30pro.com and look under the “Resources” tab. You can also direct your patients to novologmix70-30.com, where they can access the resources themselves.

Important Safety Information (cont’d)Warnings and Precautions (cont’d)• Renal and Hepatic Impairment: Like all insulins,

NovoLog® Mix 70/30 requirements may be reduced in patients with renal impairment or hepatic impairment.

• Hypersensitivity and Allergic Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, may occur with insulin products, including NovoLog® Mix 70/30.

• Fluid retention and heart failure can occur with concomitant use of PPAR-gamma agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog® Mix 70/30. 7

Page 8: HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG · HUMAN PREMIX INSULIN AND PREMIX INSULIN ANALOG Physicians often prescribe analog basal and bolus insulin. ... Premix insulin analog

A1C $

EXPLORE THE BENEFITS OF NOVOLOG® MIX 70/30

Improved glycemic control5

Simple unit-to-unit conversion from human premix insulin

FlexPen®—a discreet, prefilled, dial-a-dose insulin

delivery device

Patient support resources including Cornerstones4Care®

Broad coverage3

Similar co-pay to human premix insulin on most managed care plans3

For additional information, product samples, and more, visit

novologmix70-30pro.com

Cornerstones4Care®, FlexPen®, NovoFine®, Novolin®, and NovoLog® are registered trademarks of Novo Nordisk A/S.

© 2015 Novo Nordisk All rights reserved. 0615-00027255-1 July 2015

Important Safety Information (cont’d)Adverse Reactions• Adverse reactions observed with insulin therapy include hypoglycemia, allergic

reactions, local injection site reactions, lipodystrophy, rash, and pruritus.

Use in Specific Populations• The safety and effectiveness of NovoLog® Mix 70/30 have not been established

in pediatric patients. Clinical studies of NovoLog® Mix 70/30 did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients.

REFERENCES: 1. Weyer C, Heise T, Heinemann L. Insulin aspart in a 30/70 premixed formulation: pharmacodynamic properties of a rapid-acting insulin analog in stable mixture. Diabetes Care. 1997;20(10):1612-1614. 2. Shah S, Benroubi M, Borzi V, et al; IMPROVE™ Study Group Expert Panel. Safety and effectiveness of biphasic insulin aspart 30⁄70 (NovoMix® 30) when switching from human premix insulin in patients with type 2 diabetes: subgroup analysis from the 6-month IMPROVE™ observational study. Int J Clin Pract. 2009;63(4):574-582. 3. Fingertip Formulary: January 2015. 4. Pfützner A, Reimer T, Hohberg C, Frøkjær LPF, Jørgensen C. Prefilled insulin device with reduced injection force: patient perception and accuracy. Curr Med Res Opin. 2008;24(9):2545-2549. 5. NovoLog® Mix 70/30 [prescribing information]. Plainsboro, NJ: Novo Nordisk Inc; 2015.

Please see Important Safety Information throughout. Click here for Prescribing Information.