Inova Center for

Personalized

Health Campus

July 19, 2016

An Unsustainable Path: Health and Money

Better prevention and

management of chronic

disease are critical to

improving health outcomes

and lowering healthcare costs

DeVol, R, Bedroussian, A, et al. An Unhealthy America: The Economic Burden of Chronic Disease. The Milken

Institute.

Chronic disease

accounts for 75% of

U.S health care

spending

2

Healthcare – The State of the Industry

The pursuit of

innovation is

fueling solutions

to these

challenges

3

Healthcare is undergoing

unprecedented change

Affordable Care Act

Personalized medicine

Technological innovations

Consumer demands

Prediction, prevention,

treatment innovations

Hospital mergers

Insurer

consolidation

Practice mergers

New insurance

models

Inova’s Transformation Objectives

National & international

health system Strong regional health system

Strategically focus on translating

research into clinical application Research as a collateral activity

Partner to develop, test & apply

the latest discoveries Adopts the latest technology

Fee-for-value model Fee-for-service financial model

4

Inova’s Transformation Objectives

Acute Care and Population

health focus Acute care focus

Utilizing integrated data to provide

personalized wellness & care Providing traditional diagnostic care

Developing precision strategies

for wellness and treatment

Providing individuals with

generalized approaches

Relationship-based delivery

model Transaction-oriented delivery model

5

INOVA’S VISION 2020: Personalized Health

6

Precision

2011

ITMI Launched

First ITMI Study:

Premature Birth

2012

Trio Longitudinal Study

Congenital Anomalies

Study

2013

Epic (EMR) Launched

Women’s Health Integrated

Research Center Operational

2014

Inova Lab for Genomic

Medicine Launched

First Clinical Pharmacogenomics

(PGx) test

$50 million gift for Inova Dwight and Martha

Schar Cancer Institute

Inova Women’s Health Research Center’s

first biorepository in state of Virginia

2009

Dr. John Niederhuber

named ITMI CEO

Inova Personalized Health History

7

2016

Inova launches MediMap™, a

pharmacogenomics test for newborns

Formation of Inova Molecular Tumor Board

Inova Heart and Vascular Institute opens

clinical trials unit

Commonwealth of Virginia provides funding

for Global Genomics and Bioinformatics

Research Institute

2015

Dr. Donald Trump named

ICCRI CEO

Inova takes possession of

ICPH Campus on October 1

Personalized Health

Lifestyle & Engagement

Ind

ivid

ua

l &

Fa

mil

y

Nutrition

Remote

Monitoring

Telehealth

Patient

Engagement

Sensor Technology

Mobile Health

Fitness Apps

Health and

Wellness

Biometrics

Environment

Healthy

Communities

Occupation

Recreation

Exposures

Omics

Disease

Diagnosis

Risk Profiling

Biobank

Pharmacogenomics

Genetic Sequencing

Technology

Targeted Therapy

Discovery/Development

Inova Personalized Health Information Framework

8

Info

rma

tics

Big Data

Storage EMR/EHR

Population

Health

Data

Analytics

Clinical Decision

Support Tools

“Hot Areas” in Genomic Medicine* *As identified by Dr. Eric Green, Director of the National Human Genome Research Institute (NHGRI)

Somatic Tumor Profile Targeted genomic sequence analysis panel, 5-50 genes

Inova Genomics Laboratory >7 PGx tests to date, CLIA certified

Congenital Disorders Study NICU babies, whole-genome-sequence, 60-70%

successful diagnosis

MediMap™ No cost for newborns, 7 genes, 21 medications

First 1,000 Days of Life Study Whole-genome-sequence, surveys

Unique WGS Database Over 134 birth countries, genomic & phenotypic

information, EHR connectivity

9

Pharmacogenomics

Cancer Genomics

Ultra-Rare Genetic Disease

Diagnostics

Genomic Medicine

‘Test Drive’ Programs

Prenatal & Newborn

Genomic Analysis

Clinical Genomics

Information Systems

Learning Health System

Interaction

with Health

Care Provider

Genomic

Profile

Predisposition

Personal Health

& Wellness

Environmental Risks

10

“Omics” & Bioinformatics

Research & Integration

Translational Cancer

Research

Discovery & Innovation Hub

University & Commercial

Partnerships

Technology Integration

Inova Center for Personalized Health Campus Overview

11

Inova Schar

Cancer Institute

Inova Clinic

Research

Inova Wellness

Center

Inova Education

Center

Business

Accelerator

International

Medicine

Inova

Health &

Wellness

District

Activity-based Retail Social Eateries

Housing Options Public Spaces

Trails & Recreation

Sports & Activities

Wellness Hotel,

Spa & Conference Food & Nutrition

Arts, Culture

& Entertainment

Innovative Businesses

Educational Partnerships

12

ICPH

Campus as a Connected Destination Location

Inova Center for Personalized Health Campus Usage

Inova Clinic 1

Inova Schar Cancer Institute 2

Global Genomics

& Bioinformatics

Research Institute 3

Technology Tower 4

Conference and Wellness

Center 5

1 2

3

4

5

13

Multi-disciplinary clinic

• Specialists/Sub-

Specialists

• Inova 360 Program

• International Clinic

• Integrative Medicine

Access to advanced

genomic testing

Inova Clinic

INOVA CENTER FOR

PERSONALIZED HEALTH 14

Inova’s leading internal

research programs

Leading academic

research programs under

one roof

Commercial bio-tech

and med-tech research

companies

Global Genomics and Bioinformatics Institute

INOVA CENTER FOR

PERSONALIZED HEALTH 15

Resources supporting

all IT functions on the

campus

Incubation and acceleration

space for commercial

technology partners

Telehealth/virtual health

control center

Technology Tower

INOVA CENTER FOR

PERSONALIZED HEALTH 16

International center for

advanced cancer care

Translational research and

individualized treatments to

better understand, predict,

prevent, and eliminate cancer

Holistic team: researcher,

clinicians, research, genetic

counselor, nutritionist,

navigator and wellness coach

Inova Schar Cancer Institute

INOVA CENTER FOR

PERSONALIZED HEALTH 17

INOVA EDUCATION, WELLNESS AND

LEARNING CENTER

• Partnerships with educational

institutions

• Targeted wellness programs

• Advanced, medically based fitness

programs

• On-site Lifestyle kitchens

and dieticians

• Rehabilitation, physical and

occupational therapy

CONFERENCE CENTER

• State-of-the-art conference facility

• Host healthcare forums, classes

and conferences

Inova Education, Wellness, & Conference Center

INOVA CENTER FOR

PERSONALIZED HEALTH 18

The Future

“Omics”

Health Care

Wellness and Healing

Fitness and Rehabilitation

Life Kitchens, Bio-agriculture, Nutrition Center

Hospitality, Restaurants, Retail, Residential

Technology

19

A Picture of Success

Targeted

therapeutics

Connected

information

from bench to

bedside

People

living longer

without

disease

Care

Connect Grow

Innovate

Health care

delivering value

at reduced

cost

Value

20