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ESTUDIO ANALÍTICO DEL HIDROARSENIC I SMO CRÓNICO REGIONAL END É MICO EN SANTIAGO DEL ESTERO. INFORME DE AVANCE. M. Olivera*; J. Navoni*; J. Tschambler**; G. Bovi Mitre**; G. Paredes***; S. Farías****; Edda Villaamil* - PowerPoint PPT Presentation
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INFORME DE AVANCE
M. Olivera*; J. Navoni*; J. Tschambler**; G. Bovi Mitre**; G. Paredes***; S. Faras****; Edda Villaamil*
*CENATOXA- FFyB-UBA; **Grupo INCA- FI- UNJ; ***M de Salud- Sgo. del Estero; **** CoNEA
ESTUDIO ANALTICO DEL HIDROARSENICISMO CRNICO REGIONAL ENDMICO EN SANTIAGO DEL ESTERO
ObjetivosDeterminar la concentracin de As total en muestras de orina
Analizar el patrn de excrecin de las distintas formas arsenicales provenientes del metabolismo del arsnico inorgnico
Evaluar el aporte de arsnico a travs de la dieta
Metodologa Analtica Determinacin de As total por generacin de hidruros- espectrometra e absorcin atmica (HG-AAS)
Cuantificacin de As inorgnico (III y V, y las formas metiladas MMA y DMA), utilizando generacin de hidruros- espectrometra de absorcin atmica- inyeccin en flujo (FI-HG-AAS)
Metodologa Analtica
Evaluacin del patrn de excrecin de las distintas especies arsenicales utilizando Cromatografa de intercambio inico acoplado a generacin de hidruros- espectrometra de absorcin atmica (HPLC-HG-AAS)
Muestras Se recibieron 72 muestras de orina a las que se les determin la creatinina
Se recibieron un nmero limitado de muestras de alimentos de dieta total
Todas las muestras se conservaron a - 20C hasta el momento del anlisis
Regin muestreada
Muestras
Grfico1
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
S. Lugares; 10; 16%
M. Quemado; 5; 8%
Urutau; 24; 38%
La Firmeza; 8; 13%
V.Solo; 16; 25%
Grfico2
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
S. Lugares; 10; 16%
M. Quemado;5; 8%
Urutau; 24; 38%
V.Solo; 16; 25%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos; 39; 59%
Nios; 27; 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones;31; 47%
Mujeres;35; 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
La Firmeza; 8; 13%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As en orina (g/g creat)
relacin As urinario Vs As en agua
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
36%
64%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Muestras
Grfico4
31
35
Descripcin de las muestras segn sexo
Sexo
Mujeres 53%
Varones 47%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos 59%
Nios 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones 47%
Mujeres 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As en orina (g/g creat)
relacin As urinario Vs As en agua
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
36%
64%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Grfico5
27
39
Descripcin de las muestras segun sexo
Edad
Nios 41%
Adultos 59%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos 59%
Nios 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones 47%
Mujeres 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As en orina (g/g creat)
relacin As urinario Vs As en agua
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
36%
64%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Resultados de As Total
ResultadosReferencias:1: URUTAU2: LA FIRMEZA3: VENADO SOLO4: MONTE QUEMADO5: SANTOS LUGARES
Correlacin As en agua vs. As en orina
Grfico3
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As U (g/g creat)
y = 2,2678x + 82,227R2 = 0,7584r = 0,8709
Grfico2
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
S. Lugares; 10; 16%
M. Quemado;5; 8%
Urutau; 24; 38%
V.Solo; 16; 25%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
0.7584
0.8708616423
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos; 39; 59%
Nios; 27; 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones;31; 47%
Mujeres;35; 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
La Firmeza; 8; 13%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As U (g/g creat)
y = 2,2678x + 82,227R2 = 0,7584r = 0,8709
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
36%
64%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Resultados
Grfico3
29
71
% de adultos altamente expuestos
% de adultos expuestos
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos 59%
Nios 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones 47%
Mujeres 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As en orina (g/g creat)
relacin As urinario Vs As en agua
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
64%
36%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Grfico4
36
64
% de nios altamente expuestos
% de nios expuestos
36%
64%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
......
graficos
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos 59%
Nios 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones 47%
Mujeres 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As en orina (g/g creat)
relacin As urinario Vs As en agua
cod orinaconc Aslocedadsexo
120.021342
241.641101
341.78161
419.85181
542.091432
635.581221
730.61162
820.81142
924.361112
1014.741631
1136.081532
1210.961221
1326.031191
1438.411441
1529.711442
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
64%
36%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
Evaluacin de la ingesta de As proveniente del agua en adultos y nios en la regin estudiada
Grfico2
92.6216.0666666667
1.321.32
65.1151.9
2.535.9033333333
53123.6666666667
Adultos
Nios
Veces
Hoja1
LOC.CONC. AGUA (g/l)LOC.CONC. AGUA (g/l)
LOC.CONC. AGUA (g/l)SD (mg/l)LOC.CONC. AGUA (g/l)CONC. AGUA (g/l)2L643MONTE QUEMADO10
2L6432L6431643LA FIRMEZA10MONTE QUEMADO25.3
FIRMEZA
Diferencias de medianas de As U entre jvenes y adultos
Grfico5
6
48
899
11
871
As U (mg/creat)
Grfico2
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
S. Lugares; 10; 16%
M. Quemado;5; 8%
Urutau; 24; 38%
V.Solo; 16; 25%
Hoja1
cod orinaconc Aslocedadsexoaguaconc Ascaguacorina
120.0213421020.02
241.6411011041.64Urutau124
341.781611041.78La Firmeza28
419.851811019.85V.Solo316
542.0914321042.09M. Quemado45
635.5812211035.58S. Lugares510
730.611621030.6
820.811421020.8Hombres31
924.3611121024.36mujeres35
1014.7416311014.74
1136.0815321036.08nios27
1210.9612211010.96adultos39
1326.0311911026.03
1438.41144113.238.41%HDAs urinario
1529.71144213.229.7131.531357.16
1619.68112113.219.6825.922918.7
1737.4319213.237.4349.11722.63
1860.7519213.260.7550.462668.35
1953.021921053.0226.851186.32
20354.98142210354.9829.062530
21219.5718110219.5718.12104.17
22344.73112210344.7333.861352.41
2379.371911079.3741.53690.21
2443.9646421043.9638.542581.43
2530.7141821030.71214.5
2652.13411235.451566.4
27.44016.93539.9
2960.5542825.1344.73
3028.8543521028.8514.43476.31
3120.6211121020.62
32481.765492378481.76
331186.3232319261186.32
341496.6232919261496.62
351068.9234619261068.92
36948.775261378948.77
37563.955522449563.95
382622101
391094.3752614491094.37
401357.1637819261357.16
412918.6636529262918.66
421722.6333219261722.63
432638.3532429262638.35
443399.963619263399.96
46253031429262530
472104.1734129262104.17
483918.13419263918.1
492458.53629262458.5
501352.4131629261352.41
511390.2133229261390.21
52.351
532581.4332129262581.43
542812.53519262812.5
55214.5244219.7214.5
56510.926219.7510.9
5768.3215132.768.3
58137260232.7137
59111266132.7111
60438274114.9438
61432.932681530432.93
631566.451323781566.4
642298.8652124012298.86
661047.954824491047.9
67151251424491512
681057.955225191057.9
69615.225481133615.22
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graficos
0.7584
0.8708616423
graficos
27
39
Descripcin de las muestras segun sexo
Edad
Adultos; 39; 59%
Nios; 27; 41%
Hoja3
31
35
Descripcin de las muestras segn sexo
Sexo
Varones;31; 47%
Mujeres;35; 53%
24
8
16
5
10
descripcin de las muestras de orina analizadas
Origen
V.Solo; 16; 25%
La Firmeza; 8; 13%
Urutau; 24; 38%
M. Quemado;5; 8%
S. Lugares; 10; 16%
1357.16
2918.7
1722.63
2668.35
1186.32
2530
2104.17
1352.41
3690.21
2581.43
214.5
1566.4
539.9
344.73
476.31
p=0,071
% de Elevado dao
As urinario (gAs/g creat)
grado de dao al DNA Vs. Conc urinaria de As
y = 46,33x + 442,18R2 = 0,4237
20.02
41.64
41.78
19.85
42.09
35.58
30.6
20.8
24.36
14.74
36.08
10.96
26.03
38.41
29.71
19.68
37.43
60.75
53.02
354.98
219.57
344.73
79.37
43.96
30.71
28.85
20.62
481.76
1186.32
1496.62
1068.92
948.77
563.95
1094.37
1357.16
2918.66
1722.63
2638.35
3399.96
2530
2104.17
3918.1
2458.5
1352.41
1390.21
2581.43
2812.5
214.5
510.9
68.3
137
111
438
432.93
1566.4
2298.86
1047.9
1512
1057.9
615.22
Conc. As en agua (g/l)
Conc. As U (g/g creat)
y = 2,2678x + 82,227R2 = 0,7584r = 0,8709
cod orinaconc Aslocedadsexo
120.021342UrutaLa FirmezaV. SoloM. QuemadoS. Lugares
241.641101JAJAJAJAJA
341.78161n1410357101528
419.85181Promedio726128026727451846524115391013
542.091432Mediana393326221426711610------371539668
635.581221Mnimo20116811113521069------291512482
730.61162Mximo344355511438391829196015662299
820.81142Dif. de medianas64889911871
924.361112Dif de maximos1173999526
1014.741631
1136.081532UrutaLa FirmezaV. SoloM. QuemadoS. Lugares
1210.961221Dif. de medianas64889911871
1326.031191
1438.411441ULFVSMQSL
1529.71144264889911871
1619.681121
1737.43192
1860.75192
1953.02192
20354.981422
21219.57181
22344.731122
2379.37191
2443.964642
2530.714182
2652.134112
27.4401
2960.554282
3028.854352
3120.621112
32481.765492
331186.323231
341496.623291
351068.923461
36948.775261
37563.955522
382622101
391094.375261
401357.163781
412918.663652
421722.633321
432638.353242
443399.96361
4625303142
472104.173412
483918.1341
492458.5362
501352.413162
511390.213322baja exposicinalta exposicin
52.351nios3664
532581.433212adultos2971
542812.5351
55214.52442
56510.9262
5768.32151
581372602
591112661
604382741
61432.932681
631566.45132
642298.865212
661047.95482
6715125142
681057.95522
69615.225481
1625nios64%
2738adultos71%
0
0
% de nios altamente expuestos
% de nios altamente expuestos
36%
64%
0
0
% de adultos altamente expuestos
% de adultos altamente expuestos
0
0
0
0
0
As U (mg/creat)
ConclusionesLos datos preliminares presentados demuestran que existe en la poblacin estudiada un gran porcentaje de personas seriamente expuestas al arsnico por el agua de bebida Se observa una muy buena correlacin entre los niveles de As en agua y el As urinario excretadoDe la poblacin estudiada el 41% fueron nios y la ingesta de As por el agua de bebida lleg a superar la ingesta mxima recomendada hasta 216 veces
Conclusiones Los datos presentados ponen en evidencia la crtica situacin en que viven los pobladores de esta regin
Se recomienda con suma urgencia implementar medidas para resguardar la salud de los pobladores
Los objetivos del trabajo completo fue:Determinar la concentracin de As total en muestras de orina Evaluar el aporte de arsnico a travs de la dieta.Analizar el patrn de excresin de las distintas formas arsenicales provenientes del metabolismo del arsnico inorganico.
Los objetivos del trabajo completo fue:Determinar la concentracin de As total en muestras de orina Evaluar el aporte de arsnico a travs de la dieta.Analizar el patrn de excresin de las distintas formas arsenicales provenientes del metabolismo del arsnico inorganico.
Los objetivos del trabajo completo fue:Determinar la concentracin de As total en muestras de orina Evaluar el aporte de arsnico a travs de la dieta.Analizar el patrn de excresin de las distintas formas arsenicales provenientes del metabolismo del arsnico inorganico.
Se obtuvieron 72 muestras de orina de 66 pacientes para el estudio.Se le determino el contenido de creatinina y se las frizo a -20 para conservar las especies sin que sufran algun tipo de modificacin.