Influenza Vaccine Production and Immunization Update

November 2007

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sanofi pasteur is Unique in its Involvement in Every Facet of Influenza Vaccine Supply and Distribution• Sanofi pasteur and its customers share common goals

• Raise immunization rates and improve access to vaccine• Maintain consistent communication regarding influenza vaccine

• In pursuit of our common goals, sanofi pasteur:• Closely coordinates with the Centers for Disease Control and

Prevention (CDC) and other medical and public health authorities• Manages all aspects of influenza vaccine order fulfillment• Proactively seeks to provide broad access to all customer

segments

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sanofi pasteur’s Supply Plans for 2007-2008 Influenza Season and Beyond

• Current production plan is 50M doses• Additional doses are contingent on production yields and demand throughout the

full immunization season• For example, in 2006 sanofi pasteur produced 54M doses

• Investing $150M in a new facility that will double capacity for influenza vaccine production• 100M dose production capacity

• Planned increase for single-dose presentation

• This new facility is expected to come on-line for the 2008-2009 influenza season

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020406080100120140197919841989199419992004DosesProducedDosesdistributed

0

20

40

60

80

100

120

140

Doses Produced Doses Distributed

A Record 120M Doses Were Supplied for the 2006-2007 Influenza Season

Source: CDC, Greg Wallace,Vaccine Supply & Assurance Branch

Mil.

Dose

s

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Vaccine Supply Expected to Increase Significantly in the Short-Term* (millions of doses)

*Based on data presented at the 2/21/07 Advisory Committee on Immunization Practices meeting and sanofi pasteur estimates

Manfacturer 2006 2007 2008sanofi pasteur 54 50 50Other Companies 66 97 120Total 120 147 170

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Distribution Goals Designed to Address Each Season’s Unique Dynamics

• Provide broad access across all customer segments • Increase immunization rates in line with the CDC’s Healthy

People 2010 goals• Reach all market segments as equitably as possible

• High-risk patients are served across multiple access points

• Support the CDC’s annual influenza recommendations• Fully implement last year’s 6-59 month of age immunization

recommendation • Educate market on the revised ACIP recommendation* for 2

doses in naive or partially immunized patients 9 years of age and younger

• Prepare market for expected supply growth

*ACIP released 2007-2008 recommendations later in 2007

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5%

30%

32%

25%

8%

Sanofi pasteur provides influenzavaccine across all customer segments

Private Office-Based Providers

Public Health‡

Hospitals/ Long-Term Care

Facilities/Institutions

Retail Pharmacies

CIP†/VNAA

2006-2007 Direct and Indirect Sales*(% of doses committed)

• Vaccines for Children Program

• State and Local Public Health Departments

• US Veterans Administration

• US Military

‡ Historically, Public Health administers approximately 22% of the overall influenza market supply

* Source: sanofi pasteur internal estimates of 2006-2007 shipping results† Community Immunization Provider

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Request Fulfillment Process – Shipping• Shipping began as soon as vaccine was released by the FDA

in August • Virtually no inventory is stored during peak demand periods

• Shipping notifications are sent one to two weeks prior to shipment to inform customer of delivery window• Typically occurs prior to final product release, which prevents

the identification of an exact delivery date• To identify an exact delivery date, inventory would need to be

built which would only delay shipment

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Request Fulfillment Process – Shipping• Two to three partial shipments per customer are planned to

ensure that we provide broad access to all customer segments throughout the entire immunization season • Supported by the CDC as a “best demonstrated practice”• More costly for sanofi pasteur, but supports the public need• Full shipments would limit the number of customers receiving

early season doses

Faces of Influenza: Consumer Awareness Campaign

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Faces of Influenza - Agenda

• Situational analysis of upcoming influenza

season• What is the Faces of Influenza?• 2006 program success• Activities for 2007-2008 influenza season• Benefits to the community

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Situation for 2007-2008 Influenza Season

• Influenza immunization recommendations apply to 218M

Americans• Moving towards universal recommendations for 300M Americans

• US supply to surpass demand• A record 120M doses supplied in 2006, however later than

expected• Between 130-170M doses may be available in the next few years

• Consumer awareness regarding the seriousness of Influenza

and the safety of the vaccine is low• It will be extremely challenging to immunize 130-170M

people during the current 2-3 month immunization season • Need to utilize the entire influenza season

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Faces of Influenza Highlights What is Faces?

• Faces of Influenza is a consumer awareness campaign developed

through a collaboration between the American Lung Association

and sanofi pasteur

• Goal of the campaign: put a “face” on influenza illness and help

Americans understand need for annual vaccination

• Help people personally identify with influenza

• See themselves and loved ones among Centers for Disease Control

and Prevention (CDC) recommended groups for immunization

• Stress seriousness of influenza throughout full immunization season

• Stress the safety of influenza vaccine

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Faces of Influenza Highlights – 2006

Campaign Results:• More than 550 million total media impressions• Public service announcements ranked in top 12% of campaigns • Six regional events in Phoenix, Detroit, Minneapolis/St. Paul,

Philadelphia, Seattle, and Houston, secured significant media

coverage for local Lung Associations:• 36 million media impressions

• Activities in December and January fueled coverage of full

season utilization

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Faces of Influenza: 2007 Campaign Elements

• Comprehensive national campaign• Six targeted regional campaigns• Regional grassroots campaigns

• Local partnerships to promote influenza immunization• Opportunity to reach more consumers with an

important public health message in our local market

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Faces of Influenza National Campaign

• Celebrity-driven consumer awareness campaign featuring

Jennifer Garner• Television and radio public service announcements• National media event in New York City - November• Updated program materials including website• “Are you a Face of Influenza?” quiz• Augmented media outreach vehicles

• Television and radio satellite media tour (SMT)• Audio News Release (ANR) for radio• Mat release - newspaper ready article

• Extensive media outreach to print and broadcast outlets,

including morning shows and entertainment programs

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Faces of Influenza Regional Events

• Conduct six celebrity-supported consumer awareness campaigns

over a 4-6 week period in November and December• 4-week media outreach blitz in each market • Peaks with event in high traffic location

• Planned promotional activities include:• Conduct media relations and controlled advertising to saturate market

and drive influenza vaccination messages• In addition to national celebrity, partner with local celebrity

and physician• Conduct media events at a high-traffic location in local market • Post-event controlled promotion and media in each market• Coalition will serve as an in-market resource to media

• Locations – Detroit, Houston, Minneapolis/St. Paul, Philadelphia,

Phoenix, and Seattle

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Mission:• Provide a new platform to speak about influenza to consumers and

health-care providers• Proven, creative, and “media sexy” consumer campaign

• Increase immunization rates at the local level throughout the full

immunization season• Put a “face” on influenza illness and help your local audience understand

need for annual vaccination• Research conducted during the 2006-2007 campaign found

immunization rates increased in regional markets using the campaign

• Provide consistent messages to the public• Combat challenges faced in previous influenza seasons and education

efforts

• Assist stakeholders and coalitions in their public health advocacy

Faces of Influenza: Grassroots Regional Campaign

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Faces of Influenza Grassroots Toolkit Table of Contents• Building collaboration within our community• Consumer education materials• Media outreach materials

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Faces of Influenza Grassroots Toolkit

Building a collaboration within our communities:• How-to guide for the toolkit and campaign in a binder• Internet instructions for all materials, available via

LungNet• A Faces of Influenza presentation designed

specifically for potential partners• Timeline and key milestones for campaign

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Faces of Influenza Grassroots ToolkitConsumer education materials: • Faces of Influenza Portrait Book• Faces of Influenza brochures• Faces of influenza poster• “Are you a Face of Influenza?” quiz• Various fact sheets• Template graphics and text to link to the Faces of Influenza Web site

www.facesofinfluenza.org• An influenza background presentation for partners to use• Communication templates – newsletter article, Web article, patient and

consumer letter, physician letter, elected official, heath official, school, office on aging

• Advertising Template – newspaper, Web, radio and TV scripts• Influenza and immunization talking points and Q&A

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Faces of Influenza Grassroots ToolkitMedia outreach materials:• Press release templates

• General awareness• Clinic announcement• Educational event announcement• “Outbreak” alert• Letter-to-the-editor and Op-Ed• Various extend the season announcements• Disease backgrounder for media outlets

• Influenza talking points and Q&A• Copies of the TV and radio PSA for distribution to local media

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Faces of Influenza: Grassroots Regional Campaign

• Working together we can successfully:• Improve influenza immunization rates and reduce

influenza mortality and illness• Take a leadership role in the prevention of influenza

within our communities• Minimize the confusion of mixed messages• Leverage the power of a high profile national consumer

awareness campaign• Magnify the power of the “one voice” concept

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Faces of Influenza Regional Grassroots Campaign

How do we move forward?• Convene working group to determine how the

campaign materials can be utilized by your group to

increase consumer awareness• Lung Association/sanofi pasteur to deliver resources

to partners• Lung Association/sanofi pasteur to work with your

group to implement campaign

APR MAY JULY AUGJUNE OCTSEPT NOV DEC JAN

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Next Steps

• Questions?

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