Upload
others
View
2
Download
0
Embed Size (px)
Citation preview
Infectious disease epidemiology: slowly moving towards open science 1/24
Infectious disease epidemiology:slowly moving towards open science
Niel Hens
‘Embracing Data Management - Bridging the Gap Between Theory and Practice’,FOSTER, 4 June 2015, Brussels
Infectious disease epidemiology: slowly moving towards open science 2/24
Outline
1 Introduction
2 Infectious Disease Epidemiology & StatisticsStatisticsInfectious Disease Epidemiology
3 Discussion & Recommendations
Infectious disease epidemiology: slowly moving towards open science 3/24
Introduction
Opinions are contagious, or not?
LaCour, M. and Green, D. Science, 2014 - retracted
When contact changes minds: an experiment on transmission of supportfor gay equality
→ Outcome: Contact with minorities coupled with discussion of issuespertinent to them is capable of producing a cascade of opinionchange.
→ Retraction because, among other issues: ‘LaCour has not producedthe original survey data from which someone else couldindependently confirm the validity of the reported findings.’
The Chronicle, 21 May 2015: How 2 Persistent Grad StudentsUpended a Blockbuster Study
Infectious disease epidemiology: slowly moving towards open science 4/24
Introduction
Compliance with data sharing is challenging.
Allison, D. Science, 2009: The movement toward open data hasbegun: NIH, Science, Nature journals.
Nature Genetics requires authors to publicly deposit microarray geneexpression data:
reproduction of published work for only 2 of 18 papers.
data were either not found or incomplete or original analysisdescriptions were unclear
Public Library of Science journals require data sharing
until recently this didn’t happen
now they insist
Infectious disease epidemiology: slowly moving towards open science 5/24
Introduction
Open Science
‘Open Science - Prinzipien’ by Andreas E. Neuhold - Own work. Licensedunder CC BY 3.0
Infectious disease epidemiology: slowly moving towards open science 6/24
Infectious Disease Epidemiology & Statistics
Statistics
Statistics: clinical trials
Clinical trials are the best regulated studies
https://clinicaltrials.gov
https://www.clinicaltrialsregister.eu
JAMA: clinical trials sponsored by drug companies have to bereanalyzed by ‘academic statisticians’ before acceptance forpublication in the journal
Keiding, N. Biostatistics, 2010
There is usually much more to ‘research’ than the statistical analysis.
A ‘reasonable choice of statistical model’
Clinical trials have changed data management
Unfortunately not all guidelines and recommendations make senseand require constant re-evaluation.
Infectious disease epidemiology: slowly moving towards open science 7/24
Infectious Disease Epidemiology & Statistics
Statistics
Statistics: sharing code
Editorial board meeting @Biometrics:
issue: mandatory submission of R-package (stats software)
AEs voted against: burden & risk of packages with limited lifespan
Sharing code: ‘available upon request’
The Journal of Statistical Software: 1st rank
Infectious disease epidemiology: slowly moving towards open science 8/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Infectious Disease Epidemiology: sharing data?
Mostly observational studies or surveys:
outbreak data: SARS, H1N1, Ebola, MERS, . . .
- no clear data format
social contact survey (EU FP6 project POLYMOD)
Emerging trend: syndromic surveillance
the great influenza survey
funding issues
little political support
Infectious disease epidemiology: slowly moving towards open science 8/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Infectious Disease Epidemiology: sharing data?
The Good, the Bad and the Ugly
Infectious disease epidemiology: slowly moving towards open science 9/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
The good, . . .
Benjamin Cowling and colleagues: influenza research:
https://sites.google.com/site/bencowling88/datasets
shares raw data & code according to NIH guidelines
promote reproducibility of results
allow others to conduct their own analyses
allow others to compare other data
allow others to plan their own studies
John Edmunds and colleagues: Ebola
http://cmmid.lshtm.ac.uk/research/ebola/
shares code and results in realtime on website
publications follow later
. . .
Infectious disease epidemiology: slowly moving towards open science 10/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
The good, . . .
Jombaert et al. (Epidemics, 2014):OutbreakTools - Hackathon - Gitrepository
Hens et al. (2012): ±9800e-chapter downloads - all data &code available
1
Hens · Shkedy · AertsFaes · Van Dam
me · Beutels
Statistics for Biology and Health
Niel Hens · Ziv Shkedy · Marc Aerts · Christel Faes · Pierre Van Damme · Philippe Beutels
Modeling Infectious Disease Parameters Based on Serological and Social Contact Data A Modern Statistical Perspective
Statistics for Biology and Health
Modeling Infectious Disease Parameters Based on Serological and Social Contact Data
Niel Hens · Ziv ShkedyMarc Aerts · Christel FaesPierre Van Damme · Philippe Beutels
Statistics / Life Sciences,Medicine, Health Sciences
SBH
Modeling Infectious Disease Param
eters Based on Serological and Social Contact Data
A Modern Statistical Perspective
Mathematical epidemiology of infectious diseases usually involves describing the ! ow of individuals between mutually exclusive infection states. One of the key parameters describing the transition from the susceptible to the infected class is the hazard of infection, o" en referred to as the force of infection. # e force of infection re! ects the degree of contact with potential for transmission between infected and susceptible individuals. # e mathematical relation between the force of infection and e$ ective contact patterns is generally assumed to be subjected to the mass action principle, which yields the necessary information to estimate the basic reproduction number, another key parameter in infectious disease epidemiology.
It is within this context that the Center for Statistics (CenStat, I-Biostat, Hasselt Uni-versity) and the Centre for the Evaluation of Vaccination and the Centre for Health Economic Research and Modelling Infectious Diseases (CEV, CHERMID, Vaccine and Infectious Disease Institute, University of Antwerp) have collaborated over the past %& years. # is book demonstrates the past and current research activities of these institutes and can be considered to be a milestone in this collaboration.
# is book is focused on the application of modern statistical methods and models to estimate infectious disease parameters. We want to provide the readers with so" ware guidance, such as R packages, and with data, as far as they can be made publicly available.
9 781461 440710
ISBN 978-1-4614-4071-0
Infectious disease epidemiology: slowly moving towards open science 11/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
the bad, . . .
violation of scientific integrity
tax payer’s money
human health
Infectious disease epidemiology: slowly moving towards open science 12/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
and the ugly.
Sharing of raw data without documentation:
Even with documentation it can go wrong . . .
Infectious disease epidemiology: slowly moving towards open science 13/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Social Contact Survey
Goal:
Using data on social contacts to estimate age-specific transmissionparameters for respiratory-spread infectious agents.
Objectives
Disentangle contact behaviour from transmission process
Get insights in predictiveness of social contact data
Get new insights in the transmission process
Infectious disease epidemiology: slowly moving towards open science 14/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Social Contact Survey
Wallinga et al. (2006): Utrecht
POLYMOD
pilot study: Beutels et al. (2006)
main study: Mossong et al. (2008)
Social Contacts and Mixing Patterns Relevant tothe Spread of Infectious DiseasesJoel Mossong1,2*, Niel Hens3, Mark Jit4, Philippe Beutels5, Kari Auranen6, Rafael Mikolajczyk7, Marco Massari8,
Stefania Salmaso8, Gianpaolo Scalia Tomba9, Jacco Wallinga10, Janneke Heijne10, Malgorzata Sadkowska-Todys11,
Magdalena Rosinska11, W. John Edmunds4
1 Microbiology Unit, Laboratoire National de Sante, Luxembourg, Luxembourg, 2 Centre de Recherche Public Sante, Luxembourg, Luxembourg, 3 Center for Statistics,
Hasselt University, Diepenbeek, Belgium, 4 Modelling and Economics Unit, Health Protection Agency Centre for Infections, London, United Kingdom, 5 Unit Health Economic
and Modeling Infectious Diseases, Center for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, 6 Department of
Vaccines, National Public Health Institute KTL, Helsinki, Finland, 7 School of Public Health, University of Bielefeld, Bielefeld, Germany, 8 Istituto Superiore di Sanita, Rome,
Italy, 9 Department of Mathematics, University of Rome Tor Vergata, Rome, Italy, 10 Centre for Infectious Disease Control Netherlands, National Institute for Public Health
and the Environment, Bilthoven, The Netherlands, 11 National Institute of Hygiene, Warsaw, Poland
Funding: This study formed part ofPOLYMOD, a European Commissionproject funded within the SixthFramework Programme, Contractnumber: SSP22-CT-2004–502084.The funders had no role in studydesign, data collection and analysis,decision to publish, or preparationof the manuscript.
Competing Interests: The authorshave declared that no competinginterests exist.
Academic Editor: Steven Riley,Hong Kong University, Hong Kong
Citation: Mossong J, Hens N, Jit M,Beutels P, Auranen K, et al. (2008)Social contacts and mixing patternsrelevant to the spread of infectiousdiseases. PLoS Med 5(3) e74. doi:10.1371/journal.pmed.0050074
Received: August 8, 2007Accepted: February 15, 2008Published: March 25, 2008
Copyright: ! 2008 Mossong et al.This is an open-access articledistributed under the terms of theCreative Commons AttributionLicense, which permits unrestricteduse, distribution, and reproductionin any medium, provided theoriginal author and source arecredited.
Abbreviations: BE, Belgium; DE,Germany; FI, Finland; GB, GreatBritain; IT, Italy; LU, Luxembourg; NL,The Netherlands; PL, Poland
* To whom correspondence shouldbe addressed. E-mail: [email protected]
A B S T R A C T
Background
Mathematical modelling of infectious diseases transmitted by the respiratory or close-contactroute (e.g., pandemic influenza) is increasingly being used to determine the impact of possibleinterventions. Although mixing patterns are known to be crucial determinants for modeloutcome, researchers often rely on a priori contact assumptions with little or no empirical basis.We conducted a population-based prospective survey of mixing patterns in eight Europeancountries using a common paper-diary methodology.
Methods and Findings
7,290 participants recorded characteristics of 97,904 contacts with different individualsduring one day, including age, sex, location, duration, frequency, and occurrence of physicalcontact. We found that mixing patterns and contact characteristics were remarkably similaracross different European countries. Contact patterns were highly assortative with age:schoolchildren and young adults in particular tended to mix with people of the same age.Contacts lasting at least one hour or occurring on a daily basis mostly involved physicalcontact, while short duration and infrequent contacts tended to be nonphysical. Contacts athome, school, or leisure were more likely to be physical than contacts at the workplace or whiletravelling. Preliminary modelling indicates that 5- to 19-year-olds are expected to suffer thehighest incidence during the initial epidemic phase of an emerging infection transmittedthrough social contacts measured here when the population is completely susceptible.
Conclusions
To our knowledge, our study provides the first large-scale quantitative approach to contactpatterns relevant for infections transmitted by the respiratory or close-contact route, and theresults should lead to improved parameterisation of mathematical models used to designcontrol strategies.
The Editors’ Summary of this article follows the references.
PLoS Medicine | www.plosmedicine.org March 2008 | Volume 5 | Issue 3 | e740381
PLoSMEDICINE
(WoK: 447 citations)
Infectious disease epidemiology: slowly moving towards open science 15/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Social Contact Survey
Belgian Contact Survey
Part of POLYMOD project
Period March - May 2006
750 participants, selected throughrandom digit dialing
Diary-based questionnaire
Two main types of contact:non-close and close contacts
Total of 12775 contacts (≈ 16contacts per person per day)
Hens et al. (2009a,b)
Infectious disease epidemiology: slowly moving towards open science 16/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Infectious disease epidemiology: slowly moving towards open science 17/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Data were shared, via research gate, the VENICE platform etc
Data were misused
because they were made available
because researcher did not check the supplementary material
‘supplementary’?
. . . ?
Examples:
hepatitis A
impact of weather on social contact behaviour
reciprocity
Infectious disease epidemiology: slowly moving towards open science 18/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Infectious disease epidemiology: slowly moving towards open science 19/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Infectious disease epidemiology: slowly moving towards open science 20/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Infectious disease epidemiology: slowly moving towards open science 21/24
Infectious Disease Epidemiology & Statistics
Infectious Disease Epidemiology
Mixing patterns in EU
Infectious disease epidemiology: slowly moving towards open science 22/24
Discussion & Recommendations
Discussion & Recommendations
The Good, the Bad and the Ugly:
→ trade-off: sharing raw data requires documenting the data andsharing code
→ worthwhile the effort
There is hope: moving towards a unifying format for outbreaks(FF100, UK, 2009)
Much more work needs to be done though!
Infectious disease epidemiology: slowly moving towards open science 23/24
Discussion & Recommendations
Infectious disease epidemiology: slowly moving towards open science 24/24
Discussion & Recommendations
References
Hens, N., Ayele, G. M., Goeyvaerts, N., Aerts, M., Mossong, J., Edmunds, J. W., and Beutels, P. (2009a). Estimating the impact ofschool closure on social mixing behaviour and the transmission of close contact infections in eight European countries. BMCInfectious Diseases, 9:187.
Hens, N., Goeyvaerts, N., Aerts, M., Shkedy, Z., Damme, P. V., and Beutels, P. (2009b). Mining social mixing patterns for infectiousdisease models based on a two-day population survey in Belgium. BMC Infectious Diseases, 9:5.