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741
INDEX
Volume 188, January-March 1974
Abboud, F. M., see $chmid, P. (1., 124
‘4C-Acetylchoiine, uptake and release in isolatedsynaptosomes, effect of narcotic analgesic
drugs, 419
Action potential of cat ventricle, effect of nico-tine, 157
Adanms, H. R., .�ee Goodnmarm, F. IL, 472Na�-K�-Adenosine t riphosphatase
binding and inhibition by cardiac giycosides in
rabbit myomet ri tim , dissociat ion fronm
contractile effect, 575
interactions of digoxin and ethacrynic acid with,
605Adrenergic blocking agent (s)
beta, effect on plasma reimin activity of COIISCiOIS
rabbit, 234
beta, propranolol, effect on ketamine-inducedreimiim release in rat, 229
Adreimergic nervefunction, effects of reserpine on, 654ternminais in guinea-pig atria, reserpine-resistaimt
norepinephrine store in, 668Adreimergic receptor
beta, aimtagonism in armesthetized dog, 357
block, alpha, relationship with inhibition of
norepinephrine uptake and release aimd
immetabolism of ‘H-norepinephrine , 368Adrenergic response, alpha, indirect, to isopro-
terenol iii dog spleen, 353Adreimergic vasoconst rid ion , inhibit ion by (luini-
dine, 124
Aghajaniaim, (l. K., see Haigler, H. J., 668
Alcohol, Imeilte and chronic administration, effect
on renal henmodvnanmics and nmonovalen
ion excretion, 461
Alprenoiol-treated cat ventricular muscles, effect of niCo-
tome on action potential of, 157-treated cat ventricular nmuscle, umot ropic
effects of nicotine, 148
Alvares, A. P., �ee Bickers, I). IL, 300
Alvin, J. and Bush, M. T. : The metabolic fate of
N , N’-di-nmet hoxvme� hyl-phenobarbit al in
1 he rat , 8
‘H--�.-.A.nminobutyric. acid, syrmaptosonmal 111)1 ake,regioimai differences and possii)le role ofexcimaimge processes, 429
3-(�-Anmiimoet hyl ) -1 , 2 , 4-t riazole , lust anmine rout�log, effects on cardia( coot ract iiitv , pimos-
phorylase act ival ion :111(1 cyclic adenosine
amoimophosphate i)loCked 1)� i)urinmanmide, 180
Aminophylline
effect on neuromuscular transmission in rat, 347
effect on removal of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386
Aminosalicylic acid, effects of salicylate andprobenecid on cerebrospinal fluid transport
of, 55Amphetamines, methoxylated, effects on dog
vascular strips, 114d-Amphet amine
conmparisons with pentobarbital aimd chior-
promazine on multiple and mixed schedules,
724effects on repeated acquisition of behavioral
chains, 700
rate-dependent effects, relationship to spatialand paw preferences iim rats, 714
Analog(s)of angiotensin , influence of sarcosine substituted
in position 1, 222
of histamine, effects on cardiac contractility,
phosphorylase activation and cyclic adeno-sine monophosphate blocked by burim-
amide, 180of vasopressiim (1 -deanmino-[8-D-arginine] -vaso-
pressin), antidiuretic action jim rats, 241
Aimdrogeim
assimilation by epitheliunm and muscle of guinea-
pig seminal vesicle, 324met abolism by liver microsonmes increased by
phenobarbitai, correlat ion wit h decreasedandrogen action oim rat seminal vesicies, 287
Angiotensinanalogs, influence of sarcosine substituted in
position 1, 222
effect of quinidine on vasoconstrictor responsesto, 124
Angiotensin TI-induced cormt ractile responses inrabbit aorta, effects of imeonmycin, 472
An t icoagulan t act ion , dist ri 1)Ut id)Im , elinminat ionand, of dicumarol, 293
Anticoimvuisant activity of propranolol and givcol
nietaboiite in rat , 86
Ant iditiret ic act ioim of 1 -deanmino-[8-o-arginine}-vasopressin in unanestimetized rats, 241
Antipyrine, eiimiimatioim 1�’ liver in imman, effects
of physical St ress on , 1
Almtd)nItccio, \I. J. and Simmith, C. B. : iffects of
chronic pretreatment witim simmall doses of
reserpine upon acirenergic nerve function,
668
742 INDEX Vol. 188
Antonaccio, M. J., see Van Orden, L. S., III, 654
Aorta, rabbit, effects of neonmycin on 45Ca move-
ments and contractile responses in, 472Aronson, B. S. and Gelles, J. M. : Electrophysio-
logical effects of dopamine on sheep cardiac
Purkinje fibers, 596Aspirin and actioim of leukocytic endogenous
mediator, 516Atria
guinea-pig, adrenergic nerve terminals, reser-pine-resistant norepinephrine store in, 668
guinea-pig, effect of reserpine on adrenergic
nerve function in, 654
guinea-pig, inotropic stimuli and systolic trarms-
membrane calcium flow in, 166
guinea-pig, release of norepinephrine by phenyl-
ephrine in, 640
Atropine , effect s on t hermoregulat.ion against
body cooliimg in conscious rabbit , 400
Autoradiographic dist ri but ion of ‘4C-hernicho-linium-3 in nmouse whole body and dog brain,
77
AY 22, 241 and At’ 22, 248, senmisynthetic cardiacgi ycosides with unique lactone linkage,actions compared in dog heart. with ouabain
and dihydro-ouabain, 189
Barbital, action in nmouse, potentiation by sodiumnitrite, 481
Barbiturate, potentiation in mouse by sodiumnitrite , role of nmet hemoglobin -induced hy-
poxia, 481
Barfknecht., C. F., see Cheng, H. C., 114
Barr, G. A., Cousins, M. J., Mazze, II. I., Hitt.,B. A. and Kosek, J. C. : A comparison of therenal effects and metabolism of enflurane
and methoxyflurane in Fischer 344 rats, 257Bassett, A. L. and Gelband, H. : Nicotine and the
action potential of cat ventricle, 157
Bassett., A. L. , Wiggins, J. H., Danilo, P., Jr.,Nilsson, K. and Geiband, H. : l)irect andindirect inotropic effects of nicotine on cat.
ventricular muscle, 148Bat, influence of �19-tetrahydrocannabinoi on
cardiovascular and subcut aneous micro-
circulatory systems in, 624
Baumei, I. P., Pitternman, A., Patel, (4., I)eFeo,J. J. and Lal, H. : Mechanisms underlyingpotentiation of barbiturate action by so�dium nitrite in the nmouse: The role ofmethemoglobin-induced hypoxia, 481
Beard, J. D., see Sargent, W. Q., 461
Belis, J. A., see Mawhinney, M. G., 324
Benzomethamine, absorption in rats treated
with antibiotics, 277Bertollini, A., see Levi, (1., 429Betazoie, histanmirme analog, effects on cardiac
cont ract ility , phosphorylase act ivat ion and
cyclic adenosine nmonophosphate blockaded
by burimamide, 180Bianchi, C. P. and Bolton, T. C. : Effect of hyper-
tonic solutions and “glycerol treatment”
on calcium and magnesium Immovements of
frog skeletal muscle, 536
Bickers, 1). IL, Kappas, A. aimd Alvares, A. P.:
1)ifferences in inducibility of cutarmeous and
Bile
hepatic drug nmetabolizing enzynmes andcytochronme P-450 by polychiorinated hi-
phenyls and 1,1,1-trichloro-2,2-bis(p-chlo-
rophenyl)ethane (1)1)T), 300
excret ion of morphine , nmorphine-3-glucuronide
and other compounds, effects of novobiocin,
504nman and dog, excretion of ouabain jim, 615
Bilirubin, effects of novobiocin on biliarv excre-
tion of, 504
Bloch, H., see Misra, A. L., 34
Blood, rat, distribution of hexobarbital in, 15
Blood pressure, after decarhoxylase iimhibition in
cat, effect of L-dOpa, 107
Blood urea nitrogen, in rabbits, effect of synthetic
salmon caicitonin, 318
Bolton, T. C., see Bianchi, C. P., 536
Braindog, autoradiographic distributioim of ‘4C-henmi-
cholinium-3 in, 77
dog, levels of bevo-nmethadone-1-’H irm, 34
synaptosonmes, rat, effect of narcotic analgesic
drugs on uptake and release of imeurotrans-mitters in, 419
synapt osomes , rat , upt ake of ‘H --y-anminobutyric
acid and ‘4C-glut amate, regional differencesand possible role of exchange processes, 429
Brown, 1). J., Miller, F. N., Longnecker, 1). E.,
Greenwald, E. K., Harris, P. I). and Forney,H. B. : The influence of A9-tetrahydrocan-nabinol on cardiovascular and subcutaneous
microcirculatory systems in time rat, 624
Bufotenine , action on 5-hydroxyt rypt amine re-ceptors in umbilical vasculature, 336
Bumpus, F. M., see Hall, M. M., 222
Burimamide, blockade of effects of histanmine andanalogs on cardiac contract ility , phos-phorylase activatioim and cyclic adenosine
monophosphate, 180
Burkhart, S. M., see Ledsonme, J. IL, 198
Bush, M. T.
see Alvirm, J., 8see Holcomb, R. H., 15
Butacaine, blockade of potassium exchange inmuscle by, comparison with SKF 525-A, 553
Butler, T. C., see 1)udlev, K. H., 491
But oxami ime , effect on isoproterenol -inducedresponses in anesthetized dog, 357
1974 INDEX 743
Calcitonin, synthetic salmon, effect oim glucose,blood urea nitrogen and serum electroiytesin rabbits, 318
Calciumflow, systolic t ransnmenmbrane, inot ropic st inmitii
and, in depolarized guinea-pig atria, 166
movements in frog skeletal muscle, effect of
hypertonic solut ions and ‘ ‘ glycerol t reat -
ment.,” 536Calcium-45, movements in vascular sinoothnmuscle,
effects of neomycin, 472
Carbachol, effect on cyclic adenosine monophos-phate in rabbit superior cervical ganglion,
676
Cardiac contractilityblockade by burimamide of effects of imistanmine
and analogs on, 180
effects of nicotine, 148
relationship to calcium flow in depolarizedguinea-pig atria, 166
Cardiac effects of histamirme and analogs blocked
by burinmamide, 180
Cardiac glycosidesbinding to rat. and rabbit myometrium, 582influence of position of attachmeimt. of lactone
ring to steroid nucleus on action of, 189inhibitioim and binding of Na�-K�-adeimosine
triphosphatase in rabbit myonmetriunm by,
dissociation from contractile effect, 575
Cardiovascular effectsof intracerebroventricular d-, 1- and dl-pro-
praimoiol in conscious rabbit, 394
of A9-tetrahydrocannabinol in bat, 624produced by purified scorpion toxin in rat , 207
Cardon, P. V., see Watanabe, A. M., 107
Cassano, Ci. B., see 1)onmino, E. F., 77
Cat(s)
effect of i�-dopa on blood pressure and sympa-thetic nerve activity after decarboxylase
inhibition iim, 107
effect of methyiguarmidine on norepinepimrinemetabolism in isolated, perfused spleen and
heart of, 93
effects of salicylate and probenecid on cerebro-spinal fluid transport of penicillin, amino-saiicyiic acid and iodide in, 55
nictit ating menmbrane, release of imorepinephrineby phenylephriime in, 640
pithed, nictitating membrane, sensitivity tob-norepinephrine after denervat ion or
decentralization, 630
prostaglandin inhibit ion of metabolically in-
duced coronary vasodilation in, 135
spleen, relationships between alpha receptorblock, inhibition of norepinephrirme uptakeand release and metabolism of ‘H-norepi-
nephrine in, 368
ventricle, effect of nicotine on action potential
of, 157
ventricular muscle, direct and indirect inotropiceffects of nicotine on, 148
Catecholamine
-induced changes in heart rate, antagonized bypropranolol, 198
-induced reiease of renal prostaglandin, relation
to renal endocrine function, 453
Central nervous systemdog, levels of levo-methadone-l-’H in, 34effects, metabolic disposition and, of glycol
metabolite of propranolol, 86
Cephaioridine, effect on uptake of 5-hydroxy-
indoleacetic acid by rat choroid plexus, 410
Cerebrospinal fluid
mode of elinmitmat ion of 5-hydroxyindoleaceticacid from, 410
transport of penicillin, amirmosalicylic acid and
iodide, effects of salicylate aimd probenecid,
55
Chen, J., see Levi, (1.,429
Cheng, H. C., Long, J. P., Nichols, D. E. andBarfknecht, C. F. : Effects of psychoto-mimetics on vascular strips: Studies ofmet hoxylat ed anmphet amines and opticalisomers of 2 , 5-dimet hoxy-4-methylamphet -
amine and 2 , 5-dimet hoxy -4 -bromoamphet -
amine, 114
a- and -y-Chlordane, effect on cyclic adenosine
3’ , 5’ -monophosphate -‘H formation by rat
kidney cortex, 265Chlordiazepoxide, effects on repeated acquisition
of behavioral chains, 700Chloride
excretion in dog, effect of acute and chronic
alcohol administration, 461serum, irm rabbits, effect of synthetic salmon
calcitonin, 318
Chlorpromazineabsorption in rats treated with antibiotics, 277
comparisons with d-amphetamine and chior-
pronmazine on multiple and mixed schedules,
724Choline acetylt ransferase, t raris-synaptic induc-
tion in pregangliormic neuron of peripheralsympat hetic nervous system , 439
Cholinergic receptor blocking drugs, central
effects on thermoregulation against bodycooling in conscious rabbit, 400
Choroid plexus, rat, acid transport system in, 410Clouet, I). H. and Wiliianms, N. : The effect. of
narcotic analgesic drugs on the uptake andrelease of neurotransmitters in isolated
synaptosomes, 419
Cocaineeffect on norepinephrine metabolism in isolated,
perfused cat spleen and heart , 93
744 INDEX Vol. 188
effect on removal of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386
effect on uptake and release of norepinephrine incat spleen , 368
Conney, A. H., see Levin, W., 287Contractile responses in vascular smooth muscle,
effects of neomycin, 472
Coronary vasodilat ioim , nmet abolically induced,prostaglandin inhibitiorm of, 135
Corticoids, giuco-, nmineralo- armd gluconmineralo-,pharnmacodynamic iimteract ions wit h various
drugs, 45
Corticosterone , interact ions wit h various drugs,45
Cousins, I�I. J., see Barr, G. A., 257
Cubeddu, ii., X., Langer, S. Z. and Weiner, N.:
The relationships between alpha receptorblock , inhibit ion of norepinephrine uptakeand time release aimd metabolism of ‘H-norepinephrine, 368
Cubeddu, L., X., Mosiimmanim, W. and Weiner, N.:The effect of nmethylguanidine on norepi-
nephrine umet aboiisnm in isolat ed , perfused
spleen and heart, 93
Cucinell, S. A, see Swartz, B. 1)., 1Cyclic adetmosine monophosphat e
blockade by burimanmide of effects of histamine
and analogs oim, 180
synaptically nmediated increase in rabbit
superior cervical ganglion, 676Cyclic adenosine monophosphate-’H fornmat ioim by
rat kidney cortex, effect of 1)l)T, 265
Cytochronme P-450, inducibility by polychlori-
nat.ed bipheimyls and 1)1)T, 300
Daniel, E. E., see Murtimy, IL V., 575, 582
Danilo, P., Jr., see Bassett, A. L., 148
1)a Silva, 0., see Szabo, S., 45
Dayton, P. (L, see Pruitt, A. W., 248
D1)T [1 , 1 , 1-t richloro-2 , 2-his (p-chiorophenyl)-eth-ane]
effect on cyclic adenosine 3’ , 5’ -Immonophosphate-
‘H formatioim by rat kidney cortex, 265iimducibiiitv of cutaimeous and hepatic drug
nmetaboiizing eimzynmes and cytochrome P-450 by, 300
1 -Deamino-[8-o-argiimiime]-vasopressin, ant idiuret ic
action in unaimesthetized rats, 241Decarboxylase inhibition in cats, effect of i�-dopa
Oil blood pressure and sympathetic imerve
activity after, 1071)eFeo, J. J., see Batimel, I. P., 481
l.)esoxvcort icosterone acet ate , interactions with
various drugs, 451)ext.rorphan, effect Oil uptake and release of
neurot ransnmitters iim isolated syrmaptosomes,
419
Diazoxide, nietabolism in man and experinmental
animals, 248
1)ibutyryl cyclic adenosine monophosphate, ef-
fects cam neuronmuscular transnmission in rat.,447
l)icunmarol , dist ribution , elinminat ion aimd armti-
coagulant action of, 293
1)ieidrin, effect on cyclic adenosine 3’,S’-nmono-
phosphate-’H fornmat.ion l)y rat kidneycortex, 265
$-l)iet imylaminoet hyl dipheimylpropyiacet ate (see
SKF 525-A)
1)igitoxin
effects of novobiocirm on hiliary excretiorm of, 504inhibition and binding of Na�-K�-adeimosirme
t riphosphat ase in rabbit myonmet riuimm by,
dissociation from contractile effect, 5751)igoxin
bindiimg irm rabbit armd rat rmm.yonmetriunm, 582
interact ion with renal Na-K�-adenosiime tn-phosphatase, 605
met abolisnm iim hypokalenmic aimd nornmokaieniic
dogs, effect of irmsuiin and glucose, 564Dihydroergot amine, effect on Sch islosonia n)anson.i,
529
l)ihydro-ouabain, ouabain and, act ions iim clogheart compared wit h semisynthet ic cardiacgiycosides, 189
2 , 5-1 )imethoxy-4-bronmoanmphetanmine, opticalisomers, effects Ofl dog vascular strips, 114
2 , 5-i)imet hoxy-4 -nmet hylanmphet ainirme , opticalisomers, effects on dog vascular strips, 114
1)iimmet hyiphenylpiperaziniurim , interact ioim with
prostagiandin 1 � in c�it heart , 135l)iphenylhydant oiim , ahsorpt iorm in rats tneate(l
� antibiotics, 277
Dog(s)
ai)iiitv of pr�pranol�i to antagormize in(luced
changes in imeart rate irm, 198
acutely hvpokaiem i c and normokalemic , effectof insulin and glucose on nmyocardial andskelet al nmuscie upt tke of digoxiim in , 564
anesthetized, bela adrenergic receptor antago-
nism in, 357brain, autoradiographic distribution of ‘4C-
hemichoiiniunm-3 in, 77heart , cormmpanison of nat oral and seimmisynt imet ic
cardiac glycosides in, 189inhibition of adrenergic vasocoimst net ion by
quinidine in, 124inhibitory effect of i��i�phl�retiii phosphate on
platelet aggregat iOim and henmodynanmic andrespiratory changes caused by timroimmhin and
protamine in, 214interactions of digoxin and ethacrynic acid with
renal Na � J� � -:ldlenosine t niphosphatase in,
605
1974 INDEX 745
metabolism of diazoxide in, 248physiological disposition and biotransformation
of levo-nmethadone-1-’H in, 34
reimai and gastrointestinal excretion of ouabain
in, 615spleen, indirect alpha adrenergic respoimse to
isopnoterenoi in, 353
vascular strips, effects of psychotominmeticanmphetamiimes on, 114
Dollery, C. T., see Reid, J. L., 3941)onmino, E. F., Cassano, G. B. and Placidi, (1.-F.:
Autoradiographic distribution of ‘4C-hemi-choliimium-3 in mouse whole body and dog
brairm, 77
L-Dopa, effect on blood pressure atmd sympathetic
nerve act ivit y after decarboxylase iimhibi -
tion iim cats, 1071)opamine, electrophysiological effects oim sheep
cardiac Purkinje fibers, 596
‘4C-Dopamine, uptake and release in isolatedsynaptosomes, effect of narcotic analgesic
drugs, 419Douglas, J. II., Jr., see Needlenmalm, P., 453Drug interactioims
among glucominenalocont icoids , pregnenolone -
16a-carbonitnile and various drugs, 45
digoxin and ethacrynic acid with renal Na�-K�-adenosine tniphosphatase, 605
Drug-receptor reaction, adsorption isotherimm us.
ion-exchange models for, 520
Dudley, K. H., Butler, T. C. aimd Johimsoim, D.:Chemical studies of potential relevaimce to
penicillin hypersensitivity : Kitmetic st tidies
of methicillin, phenoxymethylpeimiciliin andtheir penicillenic acids, 491
1)yer, I). C. : Fvidence for the actiorm of (1-lysergic
acid diethylanmide, mescaline and bufote-nilme on 5-hydroxytryptanmine receptors inumbilical vasculature, 336
Electrolytes, seruimm, in rabbits, effect of syrmthetic
salmon calcit.onin, 318Electrophysiological effects of dopamiime on sheep
cardiac Purkinje fibers, 596
Endnin, effect on cyclic adenosine 3’,S’-nmono-phosphate-’H formation by rat kidney
cortex, 265Enfiuirane, renal effects and nmetabolisnm in Fischer
344 rats , comparison wit h nmet hoxyflurane,
257Enzymes, drug metabolizing, cutaneous and
hepatic, inducibility by polychiorinated
biphenyis and .L)DT, 300(- )-‘4C-Ephednine, accunmulation by pigmented
and nonpigmented iris, 342Epinephnine-induced release of renal prosta-
glandin, relation to renal function, 453
Etimacrynic acid , interactiorm with renal sodium-
pot assium -act ivated adenosine t niphospha-
tase, 605
Ethanol, pentobarbital and, differential effects on
sleep time in C57BL and BALB mice, 27Exchange processes, possible role in regioimal dif-
ferences in synaptosomal uptake of ‘H-
y-anminobutynic acid and “C-glut aimmate, 429
Faraj, B. A., see Pruitt, A. W., 248
Feller, D. II., see Patil, P. N., 342Feisenfeld, A. J., see Park, J. P., 353
Fluorocortisol acetate , interactions with various
drugs, 45
Forney, II. B., see Browim, 1). J., 624Francis, D. J., Georoff, M. E., Jackson, B. and
Marcus, F. I. : The effect. of insuliim andglucose on the nmyocardial and skeletalrmmuscle uptake of tritiated digoxirm in acutely
imypokalenmic and normokalenmic dogs, 564Franco, I. , see Freire-Maia, L. , 207
Freire-NIaia, L. , Pinto, G. I. and Franco, I.:Mechanism of the cardiovascular effects
produced by purified scorpion toxin in therat, 207
Frog
immuscle, blockade of potassium exchange bySKF 525-A irm, conmpanison with butacaine,
553skeletal nmuscle, effect of hypertonic solutions
and “glycerol treatnment” on calcium and
Immagimesituim nmovenmeimts of, 536
Frohnman, L. A., see Goldnman, J. II., 310
Fujinmoto, J. 1\�I., see Snmith, 1)., 504
(iaffimey, T., see Saelens, D. A., 86
Ganglion , rabbit superior cervical , synapticallymediated cyclic adetmosine immonopimosphateirmcrease irm, 676
Gelbaimd, H., see Bassett, A. L., 148, 157
(ielles, J. M., see Aronson, H. S., 596
Georoff, � E., see Francis, D. J., 564
Gerber, N., see Holcomb, II. II., 15
Giant axons, squid, effect of strychnine on ionicconductances of, 66
Gillis, C. N., see Twasawa, Y., 386
Glick, S. D. armd Jerussi, T. It. : Spatial and pawpreferences in rats: Their relationship to
rate-dependent effects of (l-anmphetanmine,
714
Glucocorticoid admirmistration to rats, effects on
in vitro intermediary metabolisnm, 310
Glucose
effect. on nmyocardial and skeletal nmuscle uptakeof digoxin in acutely hypokalenmic and
normokalemic dogs, 564
746 INDEX Vol. 188
in rabbits, effect of synthetic salmon calcitonin,
318
metaboiisnm in rat., effects of glucocorticoids, 310‘4C-Glut anmat e , synapt osonmal tipt ake , regional
differeimces and possible role of exchangeprocesses, 429
“Glycerol treatnment,” effect orm calcium and mag-nesiuni movements of frog skeletal muscle,
536
Glycosides, cardiac (see Cardiac glycosides)
Goldman, J. H. and Frohman, L. A. : Effects ofglucocorticoid administration to rats on in
vitro intermediary met abolism, 310Goodman, F. II., Weiss, (1. B. and Adams, H. IL:
Alterations by neomycin of 45Ca movementsand coimtractile responses in vascular
smooth muscle, 472Goodwin, 1). W., see Hill, S. Y., 415
Greengard, P., see Kalix, P., 676
Greenwaid, E. K., see Brown, D. J., 624
Guinea pig
atria, adrenergic nerve terminals, reserpine-
resistaimt norepinephrine stores in, 668
atria, effect of reserpine on adrenergic nerve
furmction irm, 654
atria, inotropic stimuli and systolic transmem-
brane calcium flow in, 166
atria, release of imorepinephrine by phenyl-
ephrine in, 640
heart , blockade by burimamide of effects ofhistamine and analogs on, 180
metabolism of diazoxide in, 248
pigmented and nonpigmented iris, accumulat ionof (-)-‘4C-ephedrine by, 342
seminal vesicie, androgen assimilation by
epithelium and muscle of, 324
Guntheroth, W. G., see Park, J. P., 353
Haigler, H. J. and Aghajanian, (i. K. : Lysergic
acid diet.hylamide and serotonin : A corn-parison of effects on serotonergic neurons
and neurons receiving a serotonergic input,
688
Hall, M. � Khosla, M. C., Khairailah, P. A. andBumpus, F. M. : Angiotensin analogs: The
influence of sarcosine substituted in position1, 222
Hallucinogens, actions on sheep umbilical ar-teries, 336
Harris, P. 1)., see Browim, D. J., 624
Heart
dog, conmparison of natural and semisynthetic
cardiac glycosides in, 189
dog, levels of bevo-methadone-1-’H in, 34
guinea-pig, blockade by burirnamide of effectsof histamine and analogs on, 180
in acutely hypokalemic and nornmokalemic dogs,
uptake of digoxin in, effects of insulin aimd
glucose, 564isolated, perfused, effect of methylguanidine on
norepinephrirme met abolism in , 93
sheep , Purki nj e fibers , elect rophysiologicaleffects of dopamine on, 596
Heart rate, ability of propranolol to aimtagonizeinduced changes in, 198
Heistad, D. I)., see Schrnid, P. G., 124
‘4C-Hemicholinium-3, autoradiographic distribu-
tion in nmoiise whole body and dog brain, 77Hemodynanmic changes, caused by thrombin and
protamine, inhibitory effect of poly-
phloretin phosphate, 214
Henderson, E. G. and Voile, H. L. : Asymmetricalblockade of potassiunm exchange in muscle
by SKF 525-A: Conmparison with butacaine,
553Heptachior, effect on cyclic adenosine 3’,5’-mormo-
phosphate-’H formation by rat kidney
cortex, 265
Hexarnet honium , effect s on t hermoregulat ion
against body cooling in conscious rabbit,400
Hexobarbital
action in mouse, potentiation by sodium nitrite,
481
nmetabolic fate in rat, 15
Hill, S. Y., Schwin, H., Goodwin, D. W. andPowell, B. J. : Marihuana and pain, 415
Hiilrnan, G. it, Olsen, N. J. and Senft, A. W.:Effect of niethysergide and dihydroergot-
amine on Schistosonia mansoni, 529
Histamineand analogs, effects on cardiac contractility,
phosphorylase activation and cylic aden-
osine monophosphate blocked by burirn-
amide, 180-iimduced coimtractile responses in rabbit. aorta,
effects of neomycin, 472
Hitt, B. A., see Barr, G. A., 257
Holcomb, li. IL, Gerber, N. and Bush, M. T.:The metabolic fate of hexobarbitai in the
rat, 155-Hydroxyindoleacetic acid, mode of elimination
from cerebrospinai fluid, 410
5-Hydroxyt rypt amine (see also Serotonin)effect of quinidine on vasoconstrictor responses
to, 124
receptors in dog vascular strips, effects of
psychotomimetic amphetamines, 114
receptors in umbilical vasculature, action ofLSD, mescaline and bufotenine on, 336
removal from puimotmary circulation, effect. of
drugs, 386Hypertonic solutions, effect on calcium and mag-
nesium movements of frog skeletal muscle,536
1974 INDEX 747
Jackson, B., see Francis, 1). J., 564
J#{228}hnchen, 1’�. and Levy, (1. : Relationship between
Hypoxia , nmet henmoglobi im-iimduced , role in po-tentiation of barbiturate action by sodiumnitrite in nmouse, 481
Tmipramine, effect oim removal of norepineplmrineand 5-hydroxytryptanmine from rabbit lung,
386
Inagaki, C., see Martinez-Maldonado, M., 605
Indocyanine green, elinminatiorm by liver in man,
effects of physical stress on, 1
Indoleacetic acid, effect on uptake of 5-hydroxy-
indoleacetic acid by rat choroid plexus, 410
Inotropic effects, direct and indirect, of nicotitme
on cat ventricular nmuscle, 148
Inot ropic st imuli, syst olic transnmenmbrane calciunmflow and, in depolarized guinea-pig atria,
166
Insect icides, halogenated hydrocarbon , effect. on
cyclic adenosine 3’ , 5’ -monophosphat e -‘Hformation by rat. kidney cortex, 265
Insulin, effect on nmyocardial and skeletal nmuscie
uptake of digoxin in acutely hypokalemicand normokalemic dogs, 564
Intestinedog, levels of levo-nmethadone-1-’H in, 34small, rat, effect of armtibiotics on drug absorp-
tion from, 277
Iodide, effects of salicylate and probenecid oncerebrospinal fluid transport of, 55
Ton, monovalent, excretion, effect of acute aimdchronic alcohol adnministration on, 461
Ion-exchange models, us. adsorption isothernm fordrug-receptor reaction, 520
Ionic conductances of squid axon nmenmbrane,
effects of strychnine, 66
Iris, pigmented and imoimpigmented, accunmulat ionof (-)-14C-ephedrine by, 342
Isoproterenol
cardiac effects in depolarized guinea-pig atria,
166
indirect alpha adrenergic response in dog spleen
to, 353
-induced cardiovascular responses in anes-
thetized dog, effects of beta adrenergic
receptor blocking agents, 357-induced changes in heart rate, antagonized by
propranoiol, 198
interaction with prostaglandin E1 iii cat heart,
135
Iwasawa, Y. and (lillis, C. N. : Pharmacological
analysis of norepinephrine and 5-hydroxy-tryptanmine removal from the pulmonary
circulation : 1)ifferentiation of uptake sitesfor each anmine, 386
distribution , elimination aimd aimticoagulant
action of dicumarol, 293Jakschik, B., see Needieman, P., 453Jerussi, T. P., see Glick, S. I)., 714
Johnson, 1)., see Dudley, K. H., 491
Johnson, E. M., Jr., see Needleman, P., 453
Judy, W. V., see Wat.anabe, A. M., 107
Kabela, E., see Mendez, It., 189
Kacew, S. aimd Singhal, H. L. : Effect of certainhaiogenat ed hydrocarbon insect icides on
cyclic adenosine 3’ , 5’ -nmonophosphate-’H
formation by rat kidney cortex, 265
Kalix, P., McAfee, I). A., Schorderet, M. and(.reengard, P. : Pharmacological analysis of
syimapticaliy nmediated increase in cyclic
adenosine monophosphate in rabi)it superior
cervical gaimglion, 676Kanmpschrnidt, H. F., see Merrinman, C. H., 516
Kappas, A., see Bickers, D. IL, 300Kellett , H. P., see Ledsome, J. H., 198
Ket amine-induced cardiovascular Stimulation,renism release and, in rat, 229
Khairallaim, P. A., see Hall, M. 1�I., 222
Khosla, M. C., see Hall, M. M., 222
Kidneycortex, rat , effect of halogenated hydrocarbon
insecticides on cyclic adenositme 3’,5’-mon-ophosphate-’H formation by, 265
dog, levels of levo-nmethadone-1-’H in, 34
rat, distribution of hexobarbital in, 15
Kidwai, A. M., see Murthy, H. V., 575, 582Kimapp, 1). IL, see Saeiens, 1). A., 86Kosek, J. C., see Barr, G. A., 257Kourounakis, P., see Szaho, S., 45
Krejl�i, I., see V#{225}vra,I., 241
Kuhn, W. L., see Tsai, T. H., 630
Lactoime ring, position of attachnment to steroidnucleus as influence on action of cardiac
giycosides, 189
Lal, H., see Baumel, I. P., 481
Langer, S. Z.see Cubeddu, L., X., 368
see Luchelli-Fortis, lvi. A., 640Leander, J. 1). and McMiilan, D. E. : liate-de-
pendent effects of drugs. I. Conmparisons of(/-amphetamine, pentobarbital and chlor-
promazine on multiple and nmixed schedules,724
Ledsome, J. IL, Keilett, H. P. and Burkhart, S.M. : The ability of propranolol to antagonizeinduced changes in heart rate, 198
Lester, 1)., see Randall, C. L., 27Leukocytic endogenous mediator, actioim of, pros-
tagiandin, aspirin and, 516Levi, (4., Bertoilini, A., Chen, J. and ilaiteri, M.:
Regional differences in the synaptosomai
748 INDEX Vol. 188
uptake of ‘H--y-aminobutyric acid and ‘4C�
glutamate and possible role of exchangeprocesses, 429
Levin, W., Welch, H. M. and Conney, A. H. : In-creased liver microsomal androgen metabo-
lism by phenobarbital : Correlation withdecreased androgen action on the seminal
vesicles of the rat, 287
Levine, H . IL, see Walsh, C. T., 277Levorphanol, effect. on uptake and release of
neurotraimsmit.ters in isolated synaptosomes,419
Levy, B., see Wasserman, M. A., 357Levy, G., see J#{228}hnchen, E., 293Lewis, P. J., see Reid, J. L., 394Lincomycin-treated rats, drug absorption in, 277
Liverdog, levels of levo-methadone-1-’H in, 34man, effects of physical stress on disposition of
drugs eliminated by, 1microsomal androgen metabolism increased by
phermobarbit al , correlat ion with decreased
androgen action on rat seminal vesicles, 287rat., distribution of hexobarbital in, 15rat , enzyme and cytochrome P-450 induction by
polychiorinated biphenyls and DDT, 300
Lloyd, J. W., see Mawhinney, M. G., 324Long, J. P., see Cheimg, H. C., 114
Longnecker, D. E., see Brown, 1). J., 624
Lorenzo, A. V., see Spector, R., 55LSD
action on 5-hydroxyt ryptamine receptors inunmbiiical vasculature, 336
effects on serotonergic neurons, comparison with
serotonin, 688Lucheili-Fortis, M. A. and Langer, S. Z. : Heser-
pine-induced depletion of t he norepineph-
rine stores: Is it. a reliable criterion for the
classification of the mechanism of action of
synipathomimetic amines, 640
Lungdog, levels of levo-methadorme-1-’H in, 34
rabbit, effect of drugs on removal of Imorepi-imephrine and 5-hydroxytryptamine from,
386Lupulescu, A. : F�ffect of synthetic salnmon cal-
citoimin mm glucose, blood urea nitrogen aimd
serunm electrolytes in rabbits, 318
d-Lysergic acid diethylamide (see LSD)
Machov#{225}, A., see V#{225}vra,I., 241
Magnesi iiimmimmovenmeimts in frog skeletal nmuscle, effect of
hypertoimic soliit iorms and ‘ ‘ glycerol t reat -rnent,’’ 536
serunm, iim rabbits, effect of synthetic salmon(alcitonin, 318
Malspeis, I.., see Patil, P. N., 342
Man
effects of physical stress on disposition of drugseliminated by liver in, 1
inhibition of adrenergic vasoconstriction by
quinidine in, 124marihuana and pain in, 415
metabolism of diazoxide in, 248
renal and gastrointestinal excretion of ouabainin, 615
Marcus, F. I., see Francis, I). J., 564
Margolies, M. N., see Selden, R., 615Marihuana and pain, 415
Mark, A. L., see Schmid, P. G., 124Martinez-Maldonado, M . , Tsaparas, N . , Inagaki,
C. and Schwartz, A. : Interactions of digoxin
and ethacrynic acid with renal sodium-
potassium -activated adenosine triphos-
phatase, 605
Mawhinney, M. G., Schwartz, F. L., Thomas, J.A., Belis, J. A. armd Lloyd, J. W. : Androgen
assimilation by the epithelium and muscle
of the guinea-pig seminal vesicle, 324
Mazze, H. I., see Barr, G. A., 257
McAfee, 1). A., see Kalix, P., 676
McMillan, D. E., see Leander, J. I)., 724McNeill, J. H. and Verma, S. C. : Blockade by
burinmamide of the effects of histamine and
hist amine analogs on cardiac contractility,
phosphorylase activation and cyclic adeno-
sine monophosphate, 180
Mecanmylamine , effect s on t hermoregulat.ion
against body cooling in conscious rabbit, 400
Melanin, relationship to mydriatic effect of (-)-
‘4C-ephedrine, 342
Mendez, IL, Pastelin, (.1. and Kabela, E. : Theinfluence of the position of attachment ofthe lactoime ring to the steroid nucleus on theaction of cardiac glycosides, 189
Merrinman, C. H., Upchurch, H. F. andKanmpschmidt, H. F. : Prostaglandin E,,
aspirin and the action of leukocytic endog-
enous nmediator, 516
Mescaline , act ion on 5-hydroxytryptamine re-
ceptors in umbilical vasculature, 336
Met abolisniandrogelm, liver microsornal, increased by pheno-
barbit al, correlation with decreased andro-
germ action on rat senmitmal vesicles, 287internmediary, in rats, effects of giucocorticoids,
310of diazoxide in nmarm and experimeimtai anmmals,
248of digoxin in acutely hypokalenmic and nornmo-
kaleimmic dogs, effect of insulin and glucoseorm, 564
ofenflurane inFischer344 rats, conmparisoim with
met imoxvflurane , 257
d)f hexobarbit al iii rat , 15
1974 INDEX 749
of levo-nmethadone-1-’H in dog, 34
of N , N’-di-methoxyniethyi-phenobarbital inrat, 8
of imorepirmephrine in isolated, perfused spleenand heart, effect of methyiguanidine, 93
of testosterotme by guinea-pig seminal vesicle,
324release and, of ‘H-norepinephrine, relationship
with alpha receptor block and inhibition of
norepinephrine uptake, 368
Metaboiite, glycol, of propranolol [3-(a-imaph-t hoxv) -1 , 2-propanediol] , cent ral nervous
svstenm effects and metabolic disposition of,
86
Methadone, effect on uptake and release of neuro-
transmitters in isolated synaptosomes, 419levo-Methadone-1 -‘H, physiological dispositioim
and biotransformation in dog, 34Methemoglobin-induced hypoxia, role in pot.eimtia-
tion of barbiturate action by sodiunm nitrite
in mouse, 481Methicillin, kiimetic studies, 491
Methoxyflurane, renal effects and nmetaboiism inFiscimer 344 rats, conmparison with enflurane,
257
N -Met hoxynmet hylphenobarbit ai , as prinmary
metabolite of N , N’-di-nmet hoxynmethyl-phenobarbital in rat , 8
N , N ‘-l)i-nmet hoxymet hyl-phenobarbital, nmeta-bolic fate in rat, 8
Methylguanidine, effect on norepinephriime nmetab-oiisnm itm isolated, perfused spleen and heart,
93
Methyipimenidate, effects on repeated acquisitionof behavioral chains, 700
Met hysergide , effect on Schistosoma uuua uuson i, 529Mice
C57BL and BALB, differential effects of etimaimol
aimd petmtobarbitai mm sleep tinme in, 27central imervous system effects and nmetabolic
disposition of glycol nmetabolite of pro-
prarmolol in, 86
potentiation of barbiturate action by sodiumhit rite irm, role of nmethenmoglobirm-inducedhypoxia, 481
��hole body , nut oradiographic dist ribut ion of
‘4C-hemicholinium-3 in, 77Microcirculat ory systems, cardiovascular and sub-
cutatmeous, in bat, influence of �1’-tetrahv-
drocaimnabinol, 624Miller, F. N., see Brown, 1). J., 624
Misra, A. I.�.,Bioch, H., Vadianmani, N. L. andMule, s. J. : Physiological disposition andi)iOt raimsformatioim of bevo-nmet hadone-l -‘H
in the dog, 34
MJ 1999, effect mm cyclic adenosine nmonophosphatein rabbit superior cervical ganglioim, 676
Monkey, metabolisnm of diazoxide in, 248
Morphine
biliarv excretion, effects of novobiocin, 504effect on uptake and release of neurotransmit-
ters in isolated synaptosonmes, 419
Morphine-3-glucuroimide , biiiary excretion , effectsof novobiocirm, 504
Mosimann, W., see Cubeddu, L., X., 93Mule, S. J., see Misra, A. L., 34
Murthy, H. V., Kidwai, A. M. and Daniel, F�. E.:Dissociation of contractile effect and
binding and inhibition of Na�-K�-adenosine
triphosphatase by cardiac giycosides in
rabbit myometrium, 575Murthy, II. V., Kidwai, A. M. and I)aniel, E. E.:
Subcellular distribution of cardiac glyco-
sides in rabbit and rat myometriurn and
their binding to isolated plasma membrane,
582
Musclepotassium exchange in, blockade by SKF 525-A
compared with butacaine, 553
skeletal, frog, effect of hypertonic solutions and“glycerol treatment” on calcium and mag-
nesium movements of, 536skeletal, in acutely hypokalemic and nornmo-
kalemic dogs, uptake of digoxin in, effect of
insulin and glucose, 564
smooth, vascular, effects of neomycin on 45Ca
movements armd contractile responses in, 472ventricular, cat, direct and indirect effects of
nicotine on, 148
ventricular, cat, effect of nicotine on action
potential of, 157Myers, M. G., see Reid, J. L., 394Myomet rium
rabbit and rat, binding of cardiac glycosides iim,
582
rabbit, dissociation of contractile effect. andbinding and inhibition of Na�-K4-adenosine
triphosphatase by cardiac glycosides in, 575
Narahashi, T., see Shapiro, B. I., 66
Narcotic analgesic drugs, effect on uptake andrelease of imeurotransmitters iim isolated
synaptosomes, 419Needlenman, P., Douglas, J. H., Jr., Jakschik, B.,
Stoeckiein, P. B. and Johnson, E. M., Jr.:Release of renal prostaglandin by catechola-nmines: Relationship to renal endocrine
function, 453
Neff, N. H., see Sanipath, S. S., 410
Nelson, L. D., see Schmid, P. G., 124
Neomycin
aimd l)elmicillin-treated rats, drug absorption in,
277
effects on 45Ca movements and contractile
responses in vascular smooth muscle, 472Nerve, sympathetic (see Sympathetic nerve)
Oesch, F. : Trans-synaptic induction of choline
750 INDEX Vol. 188
Nervous systenm
central (see Central nervous systenm)synmpathetic (see Sympathetic nervous system)
Neuromuscular transmission, irm rat, effects ofdibutyryl cyclic adenosine 3’ , 5’-moimophos-phate, theophylline and aminophylline, 447
Neurons, serotonergic, comparison of effects of
LSl) and serotonin on, 688
Nichols, D. E., see Cheng, H. C., 114
Nicotinedirect and indirect effects on cat ventricular
muscle, 148effect on action potential of cat ventricle, 157
Nictitating nmembrane
cat., release of norepinephrine by phenylephrinein, 640
pithed cat, seimsitivity to l-norepineplmrine after
denervation or decent ralization , 630
Nilsson, K., see Bassett., A. L., 148
Norepinephrinecontent of guinea-pig atria, effect of reserpiime,
654
effect of quinidine on vasoconstrictor responses
to, 124
-induced changes in heart rate, antagonized by
propranolol, 198-induced contractile responses in rabbit aorta,
effects of neomycin, 472
-induced release of renal prostagiandirm, relationto renal function, 453
interaction with prostaglandin E� in cat heart.,
135
metabolism in isolated, perfused spleen andheart, effect. of methylguanidine, 93
removal from pulmonary circulation, effect ofdrugs, 386
store, reserpine-resistant, in adrenergic nerve
terminals of guinea-pig atria, 668
store, reserpine-induced depletiorm in, as criterionfor mechanism of action of sympatho-
mimetic amines, 640
‘4C.Norepinephrine, uptake and release in isolatedsynaptosomes, effect. of narcotic analgesic
drugs, 419
3H-Norepinephrine , release and nmet abolism,relationship wit.h alpha receptor block and
inhibition of norepinephrine uptake, 368l-Norepinephrine, sensit ivity of cat nictitating
menmbrane after denervation or decentrali-
zation to, 630Normetanephrine, effect. on removal of norepi-
nephrine and 5-hydroxyt rypt ami ne fromrabbit lung, 386
Novobiocin, effects on biiiary excretion of nmor-
phine, morphine-3-glucuronide armd other
compounds, 504
acetylt raimsferase in the preganglionicneuron of the peripheral sympathetic
imervous system, 439Olsen, N. J., see Hillman, G. IL, 529Ouabain
binding in rabbit and rat myonmetrium, 582cardiac effects in depolarized guinea-pig atria,
166
diimvdro-ouabain and, actions in dog heart.
compared with senmisynt.hetic cardiac giy-
cosides, 189
effects of novobiocin on biliarv excretion of, 504inhibition and binding of Na�-K�-adenosine
triphosphatase in rabbit myornetrium by,
dissociation from contractile effect, 575renal and gastrointestinal excretion in maim and
dog, 615Oxprenoloi, effects on plasma ream activity in
rabbit, 234
Park, J. P., Felsenfeid, A. J., Sands., M. P. and
(luntheroth, W. G. : Indirect alpha adre-imergic response to isoproterermol in the dog
spleen, 353Pastelin, C)., see Mendez, II., 189
Patel, C;., see Baumel, T. P., 481
Patil, P. N., Shimada, K., Feller, D. H. andMalspeis, L. : Accumulation of (-)-‘4C-ephedrine by the pigmented and the nonpig-mented iris, 342
Penicillenic acids of methicillin and phenoxy-
methylpenicillin, kinetic studies, 491
Penicillinand neonmycin-treat.ed rats, drug absorption in,
277
effects of salicylate and probeimecid on cerebro-
spinal fluid transport of, 55hypersensitivity, studies of potential relevance
to, 491
Pent obarbit alconmparisons wit h d-amphet.anmine and chlor-
promazine on multiple and mixed schedules,724
ethanol and, differential effects of sleep time inC57BL and BALB mice, 27
Pettinger, W. A., see Tanaka, K., 229
Phenobarbitaieffects on repeated acquisition of behavioral
chains, 700increased liver microsomal androgen metabolism
by, correlation with decreased androgen
action on rat seminal vesicles, 287Phenoxybenzanmine
effect on alpha receptors and uptake armd releaseof norepinephrine in cat spleen, 368
effect on contractions induced in sheep umbilical
arteries by LSD, nmescaline and bufotenine,336
1974 INDEX 751
inhibition of adrenergic vasoconstriction by, 124
effect on cyclic adenosine nmormophosphate inrabbit superior cervical gangliorm, 676
effect on renmoval of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386
Phenoxynmethylpeimicillin , kinetic studies, 491
Phentolamine
effect on alpha receptors and uptake aimd release
of norepiimephrine in cat spleen, 368effect on cyclic adenosine monophosphate iim
rabbit superior cervical ganglion, 676
effect. orm removal of norepinephrine and 5-hy-droxytryptanmine fronm rabbit. lung, 386
Phenylephrine, release of imorepiimephrine from
guinea-pig atria and cat nictitating nmenm-
brane by, 640
Phosphorus, serunm, in rabbits, effect of synthetic
salmon calcitonin, 318
Phosphorylase activation, blockade by burim-
amide of effects of histamine and analogs
on, 180
Physical stress, effects on disposition of drugs
eliminated by liver in man, 1
Pigeonscomparisons of (l-amphet amine , pent obarbit al
and chiorpronmazine on multiple and mixed
schedules in, 724
repeated acquisition of behavioral chains under
chronic drug conditions in, 700
Pinto, G. T., see Freire-Maia, L., 207
Pitternman, A., see Baumel, I. P., 481
Placidi, Cl-F., see Domino, E. F., 77
Plasmadog, levels of levo-methadone-l-’H itm, 34renin activity irm conscious rabbit, effects of beta
adrenergic blocking agents, 234
Platelet, aggregation, caused by thrombin and
protanmine, inhibitory effect of polyphlor-etin phosphate, 214
Polychlorinated biphenyls, inducibility of cu-taneous and hepatic drug metabolizing
enzynmes and cytochrome P450 by, 300
Polyphloretin phosphate, inhibitory effect. onplatelet aggregation and henmodynamic and
respiratory changes caused by thrombinand protanmine, 214
Potassium
exchange in nmuscle, blockade by SKF 525-Acompared with butacaine, 553
excretion in dog, effect of acute and chronicalcohol administration, 461
-induced contractile responses in rabbit. aorta,effects of imeomycin, 472
serum, in rabbits, effects of synthetic salmoncalcitonin, 318
Powell, B. J., see Hill, S. Y., 415
Pract.oloi, effect on isoproterenol-induced re-sponses in anesthetized dog, 357
Pregarmglionic neuron of peripheral sympathetic
nervous system , t raims-synapt ic inductionof choline acetvltransferase in, 439
Pregnenolone -16a-carbonit rile , pharmacodynamicinteractions with various drugs, 45
Preston, E. : Central effects of cholinergic-receptor
blocking drugs on the conscious rabbit’s
thermoregulation against body cooling, 400Prindoiol, effects on plasnma renin activity in
rabbit, 234
Privitera, P. J., see Saelens, D. A., 86Probenecid
effect on cerebrospinal fluid transport of peni-cillin, aminosalicylic acid and iodide, 55
effect. on uptake of 5-hydroxyindoleacetic acidby rat choroid plexus, 410
ability to antagonize induced changes in heart
rate, 198and glycol met.abolite [3-(a-naphthoxy-1 , 2-
propanediol], central nervous system effects
and nmetabolic disposition, 86effect on isoproterenol-induced responses in
anesthetized dog, 357effect on ketamine-induced renin release in rat,
229
effect. on plasma ream activity in rabbit, 234effect on removal of norepinephrine and 5-hy-
droxytryptamine from rabbit. lung, 386
-treated cat ventricular muscles, effect of nico-tine on action potential of, 157
-treated cat ventricular muscle, inotropic effects
of nicotine, 148d-, 1- and dl-Propranolol, intracerebroventricular,
cardiovascular effects in conscious rabbit,
394
Prost aglandininhibition of metabolically induced coronary
vasodilation, 135E1, and action of leukocytic endogenous media-
tor, 516renal, released by catecholamines, relation to
renal endocrine function, 453
Protamine, inhibitory effect of polyphioretin phos-
phate on platelet. aggregation and hemo-dynamic and respiratory changes caused by,
214
Pruitt, A. W., Faraj, B. A. and Dayton, P. G.:
Metabolism of diazoxide in man and experi-mental animals, 248
Psychotomimetics (see also specific drug) , effectson vascular strips, 114
Purkinje fibers, sheep, electrophysiological effectsof dopamine on, 596
Quinidinecardiac effects in depolarized guinea-pig atria,
166
752 INDEX Vol. 188
Rabbitaorta, influence of sarcosine substituted in
position 1 on potency of angioteimsin analogs
in, 222conscious, cardiovascular effects of izmt racere-
brovent ricular (1-, 1- and (lb-propranolol in,
394conscious, ceimtral effects d)f cholinergic receptor
blocking drugs Ofl thernmoregulation against.body cooliimg in, 400
conscious, effects d)f beta adrenergic blockingagents on piasnma renin activity in, 234
effect of neomvcin on 45Ca immovements andcont met ile responses in vascular smoothmuscle of, 472
effect of salicylate and probetmecid on cerei)ro-spinal fluid transport of penicillin, amitmo-
saiicviic acid and iodide in, 55
effect of synthetic sainmon caicitonin on glimcose,
blood urea nitrogeim and serunm electrolytesin, 318
lung, effect of drugs oim renmovai c)f norepineph-
rine and 5-hydroxytryptanmine fronm, 386metaboiisnm of diazoxide in, 248
immyometriunm, i)inding of cardiac glvcosides to,
582
myonmet riuni , dissociat ion of cont met ile effectand biiidiiig and inhibition of Na�-K�-
adermosine t riphosphat ase by cardiac giv -cosides in, 575
release of renal prost aglaimdi ii by cat echolaimmines,
relation to renal endocrine functioim in, 453superior cervical ganglion , syiiapt icaliy nme-
diated increase irm cyclic adenosine immono-
phosphate in, 676
Raiteri, M., see Levi, G., 429Randall, C. L. and Lester, 1). : 1)ifferential effects
of ethanol and pentobarbital on sleep tinmeiim C57BL and BALB mice, 27
Rat(s)aorta, influence of sarcosirme substituted in
position 1 on potency of angiotensin analogs
in, 222brain synaptosomes, effect of narcotic anal-
gesic drugs on uptake and release of imeuro-transmitters ‘II, 419
brain synaptosomes, uptake of ‘H--y-anm�no-hutyric acid and ‘4C-glutamate, regiormal
differences and possible role of exchaimgeprocesses, 429
cardiovascular effects produced by purifiedscorpion toxin in, 207
choroid plexus, acid transport systenm in, 410comparison of effects of LSD and serotonirm on
serotonergic neurt�ns in, 688cutaneous and hepatic drug nmetaboiizing en-
zymes and cytochronme P-450 induction bypolychiorinated biphenyis and 1)l)T, 300
dist ribut ion , eliminat ion aimd anticoagulantaction of dicumarol iim, 293
effect of dibutyryi cyclic adenosirme 3’,5’-immono-
j)h0sphIlte , theophylline and anminophyllineon, 447
effect of novobiocin during biliarv excretion of
nmorphine , rmiorpimiime-3-glucuroimide andotimer compounds in, 504
Fischer 344, comparisoim of renal effects and
immetalmoiism of enflurane and nmet hoxyflurane
in, 257
giucocorticoid administration to, effects on iii
vitro intermediary nmetabolisnm, 310kidney cortex, effect. of halogenated hydrocar-
1)01) iimsecticides on cyclic adenosiime 3’S’-nmonophosphate-’H format iotm by, 265
nietabolic fate of hexobarhital jim, 15
nmetaboiic fate of N , N’-di-nmethoxvnmethyl-
phenobarbital jim, S
Immetai)olism of diazoxide iii, 248
immyonmetriunm, i)inding of cardiac glvcosides to,
582
pharnmacodynanmic iimteract ions among gluco-,nmiime mb- and ghiconmi imeralocort icoids,
pregimenolone -16a-carbon it rile and various
drugs in, 45
pretreated with antibiotics, drug absorption in,
277
prost aglandin E � , aspirin aimd act ion of icuko-cvtic eimdogenous mediator iim, 516
renum release and ketanmiime-iimduced cardio-
vascular st imitlat ion in , 229
seimminai vesicles, correlatioim of iimcreased liver
nu crosonmal androgeim immetaholisnm by 1)heno-
harhit al wit h decreased androgeim act ion on,
287
S1)atial and paw preferences in, relatioimship to
rate-dependent effects of (/-anmphet anmine,
714
t raims-synapt ic iimduct ion of choline Icetyl-
t ransferase in pregaimglionic neuron of
peripimeral sympat het ic imervous systenm of,
439
unanest hetized, ant idiuret ic act ion of 1-
(leanmino-[8-D-argininel-vasopressin in , 241
Reid, J. 1.�., Lewis, P. J., Myers, 1�vI. G. aimd 1)ollery,
C. T. : Cardiovascular effects of intracere-
brovermtricular d-, 1- and (bl-propranoloi iim
the conscious rabbit, 394
Beimal effects of enflurane irm Fiscimer 344 rats,
conmparison with methoxvfluraime, 257
Renal function
effect of acute aimd cimronic alcohol adimministra-
tioii oil, 461
rel:mt ioim t 0 catechoianmine-iimducecl release of
prostaglandin, 453
1974 INDEX 753
cat , relatioimships between alpha receptor block,inhibitiorm of norepinephrine uptake and
Renin
activity, plasma, in conscious rabbit, effects ofbeta adrenergic blocking agents, 234
release, ket anmine-induced cardiovascular stinm-
ulatiorm and, in rat., 229
Repeated acquisition of behavioral chains, chroniceffects of drugs on, 700
Reserpirme
effects on adrenergic nerve function, 654-iimduced depletion of norepinephrine stores aS
criterion for mechaimism of action of svm-
pathonmimetic amines, 640
-resistant norepinephrine store in adreimergicnerve terminals in guinea-pig atria, 668
-treated cat ventricular nmuscle, effects of imico-
tine, 148
-treated rats, trans-synaptic iimduction ofcholine acetyltransferase in, 439
-treated vermtricuiar nmuscles, effect of nicotine
01) actiorm potential of, 157
Respiratory changes caused by throimmbin and
prot anmine , iimhibit c�ry effect of pd)iy-
phloretin phosphate, 214
Saeleims, D. A., Waile, T., Privitera, P. J., Kimapp,
1). II. and (1affney, T. : Cermtrai imervous
system effects and metabolic disposition of a
glycol inet.abolite of propranolol, 86
Salicylate, effects on cerebrospirmal fluid transport.of penicillin, aminosalicylic acid aimd iodide,
55Sampath, S. S. and Neff, N. H. : The eiizmminatioim
of 5-hydroxyindoleacet ic acid fronm cerebro-
spinal fluid: Characteristics of the acid
trarmsport system of the choroid plexus, 410Sands, M. P., see Park, J. P., 353
[1-Sarcosinelaimgiotensin and analogs, poteimcy, 222Sargent, W. Q., Simpson, J. H. and Beard, J. 1).:
The effect of aci.ite and chronic alcoholadnmirmistration on reimal heinodynanmics and
monovalent ion excretion , 461Schaefer, J.-M., see Van Orden, L. S., III, 654
Schistosoma niauisoni, effect of methysergide anddihydroergotamirme, 529
Schmid, P. U., Nelson, L. 1)., Mark, A. L., HeistadD. 1). aimd Abboud, F. M. : Inhibition of
adrenergic vasoconstriction by quinidine,
124Schorderet , M., see Kalix, P., 676Schwartz, A., see Martinez-Maidonado, M., 605
Schwartz, F. L., see Mawhinney, M. G., 324Schwin, H., see Hill, S. Y., 415
Scorpion toxin, purified, cardiovascular effects in
rat, 207
Selden, H, Margolies, M. N. aimd Smith, T. W.:Henai and gastrointestinal excretion ofouabain in dog aimd maim, 615
Selye, H., see Szabo, S., 45
Seminal vesicie(s)
guinea-pig, androgen assimilation by epithelium
and muscle of, 324rat., correlation of increased liver microsomal
androgen immetabolism by phenobarbital
with decreased androgen action on, 287
Senft, A. W., see Hillman, G. R., 529
Serotonin (see also 5-1-lydroxytrypt amine)
effects on serot onergic neurons , comparisonwith LSD, 688
-induced contractile responses in rabbit aorta,
effects of imeomycin, 472
Shapiro, B. I., Wang, C. M. and Narahashi, T.:Effects of st.rychniime on ionic conductances
of squid axon immembrane, 66
Sheep
cardiac Purki nj e fibers , elect rophvsiological
effects of dopanmine on, 596umbilical arteries, action of LSD, mescaline and
bufot en i ime d)im 5-hydroxyt rypt anmine re-ceptors in, 336
Shimada, K., see Patil, P. N., 342
Sidell, F. IL, see Swartz, H. 1)., 1
Simpson, J. IL, see Sargent, W. Q., 461
Singhal, H. L. , see Kacew, S. , 265
Skeletal nmuscle (see Muscle, skeletal)
SKF 525-A (�-diethylamiimoethyl diphenyipropyl-
acetate), blockade of potassium exchange inmuscle by, conmparisoim with butacaine, 553
Skin, rat, enzynme armd cytochroine P-450 irmduction
by polychiorinat.ed biphenyls and Dl)T, 300
Sleep time in C57BL and BALB mice, differentialeffects of ethanol aimd pentobarbital on, 27
Smith, C. B.
see Aimtonaccio, M. J., 668see Van Orden, L. S., III, 654
Smith, 1). and Fujimoto, J. M. : Alterations
produced by novobiocin during biliaryexcret ioim of morphine , morphi ne -3-gui-curonide and other compounds, 504
Smith, T. W., see Seldeim, IL, 615
Smooth muscle (see Muscle, smooth)
Sodium
excretion iim dog, effect of acute arid chronicalcohol adnministration, 461
serum, in rabbits, effect of synthetic serumcalcitonin, 318
Sodiunm imit rite , potentiation of barhit orate actionin nmouse by, role of methemoglobirm-inducedhypoxia, 481
Spector, H. and Lorenzo, A. V. : The effects of
Spleen
salicylate and probenecid on the cerebro-spinal fluid transport of peniciliin, anmino-
salicylic acid and iodide, 55
754 INI)EX Vol. 188
Talesnik, J., see Sunahara, F. A., 135
release and metabolism of ‘H-norepineph-
rine in, 368dog, indirect alpha adrenergic response to
isoproterenol in, 353dog, levels of levo-methadone-1-’lI in, 34i8Olated, perfused, effect of nmethylguaimidine on
norepinephrine metabolism in, 93Squid, axon membrane, effects of strychnine on
ionic conductances of, 66
Steroid(s)and drug interactions, 310
metabolic effects, 310nucleus, position of att.achnment of lactone rirmg
to as influence on actioim of cardiac gly-
cosides, 189Stoecklein, P. B., see Needleman, P., 453
Stokes, G. S., see Weber, M. A., 234Strychnine, effects on ionic conductances of squid
axon membrane, 66Sulfobromophthalein, effects of novobiocin on
biliary excretion of, 504Sunahara, F. A. and Talesnik, J. : Prostaglaimdin
inhibition of metabolically induced
coronary vasodilation, 135Supersensitivity of cat nictitating membrane to
l-norepinephrine, 630Swartz, H. 1)., Sidell, F. H., and Cucinell, S. A.:
Effects of physical stress on the disposition
of drugs eliminated by the liver in maim, 1
Swedenborg, J. : Inhibitory effects of polyphioretinphosphate upon platelet aggregation and
hemodynamic and respirat ory changescaused by thrombin and protamine, 214
Sympat het ic nerve, activity , after decarboxylase
inhibition in cat, effect of L-dOpa, 107Sympat hetic nervous system
dog, effects of psychotomimetic amphetamines,114
peripheral, trans-synapt ic induct ion of cholineacetyltransferase in preganglionic neuron of,439
Synapt osomesisolated, effect of narcotic analgesic drugs on
uptake and release of neurotransmitters in,419
regional differences in uptake of ‘H--y-amino-
butyric acid and ‘4C-glutamate, possiblerole of exchange processes, 429
Sympathomimetic amines, mechanism of action,
reserpine-induced depletion of norepineph-rine stores as criterion of, 640
Szabo, S., Kourounakis, P., Selye, H. and 1)aSilva, 0. : Pharmacodynamic interactions
among gluco-, mineralo- and glucomineraio-corticoids, pregnenolone-lGa-carbonitrile
and various drugs, 45
Tanaka, K. aimd Pettiimger, W. A. : lleniim releaseand ketanmine-induced cardiovascular stim-
ulation in the rat, 229Testosterone
effect on growth of semiimai vesicles in pheno-barbital-pretreated rats, 287
metabolism by guinea-pig seminal vesicie, 324Tetracyciirme, absorption iim rats treated with
antibiotics, 277
�1 9-Tet rahydrocan nabinoi , ii fi iience on cardio-
vascular and subcut aimeous nmicrocircula-tory svstenms in hat, 624
Theophylline , effects on neuroimmuscular t rans-
mission in rat, 447
Thermoregulation against body cooling in con-scious rabbit, effects of choiinergic receptor
blocking drugs, 400
Thomas, J. A., see Mawhinnev, M. (., 324
Thompson, 1). M. : Repeated acquisition of be-havioral chains tinder chronic drug coiidi-
tions, 700
Thorneil, I. IL, see Weber, M. A., 234
Thronmbin , inhibitory effect of polyphloretinphosphate on platelet aggregation and
henmodvnamic and respi rat ory changes
caused by, 214
Thynmoxamine, effect on cyclic adenosine nmono-
phosphate in rabbit superior cervical gan-
giion, 676
Thyrunm, P. T. : Inotropic stimuli and systolic
traimsmeimmbrane calciunm flow iii depolarized
guinea-pig atrium, 166
Tissues (see also specific nanme)
dog, levels of le,’o-methadone-l-’H irm, 34guinea-pig, assimiiatioim of testosterone by, 324mouse , autoradiographic dist ri but ioim of 14C_
hemicholinium-3 in, 77
Trans-synapt ic induct ion of choline acetylt miss-
ferase in preganglionic imeuron of peripheralsynmpathetic nervous systenm, 439
Triamcinoioime, iimteract iorms with various drugs, 45
1 , 1 , 1 - Trichloro - 2 , 2 - bis ( p -chioropheimyl ) et.hane(see 1)I)T)
Tsai, T. H. and Kuhn, W. L. : Sensitivity of thenictitating membrane of the pithed cat toinfusions of l-norepinephrine after deimerva-tion or decentralization, 630
Tsaparas, N., see Martinez-Maldonado, M., 605
d-Tubocuramine, effects of novobiocin on biiiary
excretion of, 504
Tyramine, responses of guinea-pig atria to, effect
of resempine, 654
TJpchurch, C. it, see Merminman, C. R., 516
Urine
man and dog, excretion of ouahain in, 615
rat, met.abolites of hexobarbital in, 15
1974 INDEX 755
Walle, T., see Saelens, D. A., 86
Vadlanmani, N. L., see Misra, A. L., 34
Vanillyimandelic acid, effect on uptake of 5-hydroxyindoleacetic acid by rat choroid
plexus, 410
Van Orden, L. S., III, Schaefer, J.-M., Aimtonac-cio, M. J. and Smith, C. B. : Fine structuralidentification of a reserpine-resistant nor-epinephrine store in adrenergic nerveterminals in guinea-pig atria, 654
Vascular responses to quinidine in dog and man,124
Vasopressin analog (1 -deamino-[8-D-arginine}-vasopressin), antidiuretic action in rats, 241
V#{225}vra,I.,Machov#{225}, A. and Krej�i, I. : Antidiuretic
action of 1 -deamino-[8-D-argininej-vaso-pressin in unanesthetized rats, 241
Ventricle
cat., direct and indirect inotropic effects ofnicotine on , 148
cat, effect of nicotine on action potential of, 157
Verapamil, cardiac effects in depolarized guinea-pig atria, 166
Verma, S. C., see McNeill, J. H., 180
Voile, H. L., see Henderson, E. (4., 553
Walsh, C. T. and Levine, R. II. : Drug absorptionin rats pretreated with antibiotics, 277
Wang, C. M., see Shapiro, B. I., 66
Wasserman, M. A. and Levy, B. : Selective beta
adrenergic receptor antagonism in theanesthetized dog, 357
Watanabe, A. M., Judy, W. V. and Cardon, P. V.:Effect of L-dOpa on blood pressure and
sympathetic nerve activity after decar-boxylase inhibition in cats, 107
Waud, D. R. : Adsorption isotherm vs. ion-ex-
change models for the drug-receptor reac-
tion, 520
Weber, M. A., Thornell, I. II. and Stokes, G. S.:Effects of beta adrenergic blocking agents
on plasma renin activity in the conscious
rabbit, 234Welch, R. M., see Levin, W., 287
Weiner, N., see Cubeddu, L., X., 93, 368
Weiss, G. B., see Goodman, F. R., 472Wiggins, J. R., see Bassett, A. L., 148Williams, N., see Clouet, D. H., 419Wilson, D. F. : The effects of dibut.yryl cyclic
adenosine 3’ , 5’-monophosphate , theophyl-
line and aminophylline on neuromusculartransmission in the rat, 447