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prosci-inc.com
Product Catalog
Immuno-OncologyRISK FREE ANTIBODIES
20Years1998 - 2018
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1PROSCI INCORPORATED
prosci-inc.com
ProSci Incorporated takes great pride in helping life science
researchers with all their antibody needs. Our extensive knowledge
and expertise enables us to create the most reliable antibodies for
consistent results. Since 1998, ProSci has produced more than
20,000 custom monoclonal and polyclonal antibodies for scientists
around the globe. As leaders in custom antibody services and as
fellow researchers, we have the knowledge and experience to satisfy
nearly any antibody need you may have. We take your research
seriously, and will provide what you need today so you may help the
world tomorrow.
At ProSci, the customer comes first. We always tailor our
offering around your needs.
Here is what some of our customers are saying about us:
“The entire team - customer service, technical staff, and
purchasing department are flexible and work with us no matter what
the obstacle.”
“I am grateful for the intimate and punctual customer service,
as well as their willingness to tailor individual services to the
customer’s needs.”
“The service is great and the antibodies speak for
themselves.”
“We worked with ProSci to develop an antibody phage display
library from which candidates could be selected. We were impressed
with the scientific expertise ProSci brought to our project as well
as the attention to detail given at every juncture. Looking forward
to future collabora-tion with them!”
Company Overview
Our experienced Research and Development team takes great care
to assure that our antibody services are performed efficiently in
order to offer the highest quality products.
ProSci’s own researchers focus on thedevelopment of new
antibodies for the detection of novel targets, and have brought the
first commercially available antibodies to market for H5N1, H1N1,
SARS, and phospho-SAMHD1.
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Immuno-Oncology
An�gen-Presen�ng Cell T-Cell
CD80 CD86
ICOSLG
B7-H3 / B7-H4
VISTA
B7-H6
B7-H7
HVEM
Gal-9
CD137L
OX40L
CD70
CD40
GITRL
CD155
CD112
CD200
CD48
?
PD-1
CD28
CTLA-4
ICOS
?
?
NKp30
TMIGD2
BTLA
TIM-3
CD137
OX40
CD27
CD40L
GITR
CD96
CD226
TIGIT
CD112R
CD200R
2B4
MHC class I/ II TCR
KIRSKIRL
LAG-3
Cytokines
Adenosine A2aR
TGFβ, IL-1, IL-6,IL-10, IL-12, IL-18
LIGHT
PD-L2PD-L1
SIGNAL
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Adapted with modifcation from:D.M. Pardoll, Na. Rev. Can. 12,
253 (2012)A.G. Ramsay, Br. J. Haematol. 14, 561 (2013)P.D. Rennert,
Nat Rev. DD. 14, 561 (2015)
Target = Risk Free mAb
= mAb
= pAb
= sdAb
= RP
Available Products
IMMUNE CHECKPOINTSprosci-inc.com/immune-checkpoint 2
An innovative research area which has moved into practical
therapeutics, Immuno-Oncology (I-O) uses the body’s own immune
system to fight cancer. ProSci is committed to support I-O
advancements through a growing catalog of I-O antibodies and custom
antibody development services.
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PRODUCTSprosci-inc.com/products 3
Product Name Host Clonality Application Reactivity Cat. No.4-1BB
Receptor Antibody Rabbit P E, WB HU XP-5100Adenosine A2a Receptor
Antibody Mouse M WB, IHC, Flow HU, MS, RAT, OTH 49-998B7-H6 Rabbit
P WB HU 60-117BTLA Antibody Rabbit P E, WB, IHC-P, IF HU 7473CD200
Antibody Rabbit P WB HU 59-437CD200R1 Antibody Rabbit P WB HU
58-219CD226 Antibody Rabbit P WB HU 58-455CD27 Antibody [LG.3A10]
(FITC) Hamster M IHC, Flow HU, MS 48-006CD276 Rabbit P E, IF,
IHC-P, WB HU, MS, RAT 8689CD28 Antibody [CD28.2] Mouse M Flow,
Func, IHC, IP HU 76-725CD40 Antibody [LOB7/6] Mouse M IHC, IP, Flow
HU, DOG 51-054CD70 Antibody Rabbit P WB, IHC-P HU 57-954CD80
Antibody [16-10A1] Hamster M FACS, Func, IHC, IF, IP MS 76-040CD86
Antibody Rabbit P E, WB HU 8681GITRL Rabbit P E, ICC, WB HU, MS
3591ICOS Antibody Rabbit P E, IF, IHC, WB HU 8685ICOSLG Antibody
[2D3] Rabbit P E, IF, IHC, WB HU 8687IDO Antibody Rabbit P E, Flow,
ICC, WB HU 36-228
IL-15 Antibody Rabbit P E, WB, Neut HU XP-5169 KIR2DL4 Antibody
Rabbit P WB, IHC-P, Flow HU 63-756
KIR2DS2 Antibody Rabbit P WB, IHC-P, Flow HU 62-043
LAG-3 Antibody Rabbit P E, WB HU, MS 8655 PD-1 Antibody Rabbit P
E,IF, IHC-P, WB HU, MS, RAT 4065 PD-L1 Antibody Rabbit P E, WB,
IHC-P, IF, Flow HU, MS, RAT 4059 SLAMF1 Antibody Rabbit P E, WB,
IHC-P, IF HU, MS, RAT 6247 SLAMF2 Antibody Rabbit P E, WB HU, MS,
RAT 6249 SLAMF4 Antibody Rabbit P E, WB, IF HU, MS, RAT 6253 TIGIT
Antibody Rabbit P WB HU, MS 61-342 TIM-3 Antibody Rabbit P E, IF,
IHC-P, WB HU 8659 VTCN1 Rabbit P E, WB HU, MS 7189
“...the ProSci antibody had the mostintense specific staining
while maintaining the
least non-specific staining...”
M. Dhar, Et al., Sci Rep (2018) 8:2592
Product Highlight
PD-L1 AntibodyCat. No. 4059
Publications:22
Top Primary Antibodies
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Polyclonal Services
IMMUNE CHECKPOINTSprosci-inc.com/immune-checkpoint 4
Product Name Host Isotype Application Reactivity Cat. No.PD-1
Antibody [4D6] Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16001PD-1
Antibody [8A4] Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16002PD-1
Antibody [7H6] Mouse IgG1 E, WB, IHC-P, ICC, IF, Flow HU
RF16003PD-1 Antibody [4C7] Mouse IgG1 E, WB, IHC-P, ICC, IF, Flow
HU RF16004PD-1 Antibody [10B3] Mouse IgG1 E, WB, IHC-P, ICC, IF,
Flow HU RF16005PD-1 Antibody [5D3] Mouse IgG1 E, IHC-P, ICC, IF,
Flow HU RF16006CTLA-4 Antibody [1E6] Mouse IgG1 E, WB, IHC-P, ICC,
IF HU RF16011CTLA-4 Antibody [2G10] Mouse IgG1 E, WB, IHC-P, ICC,
IF HU RF16012CTLA-4 Antibody [8A1] Mouse IgG1 E, WB, IHC-P, ICC, IF
HU RF16013PD-L2 Antibody [4E10] Mouse IgG1 E, WB, IHC-P, ICC, IF,
Flow HU RF16021PD-L2 Antibody [8C12] Mouse IgG1 E, WB, IHC-P, ICC,
IF, Flow HU RF16022PD-L2 Antibody [7C7] Mouse IgG1 E, WB, IHC-P,
ICC, IF, Flow HU RF16023PD-L2 Antibody [7C1] Mouse IgG2b E, WB,
IHC-P, ICC, IF, Flow HU RF16024PD-L2 Antibody [10H6] Mouse IgG1 E,
WB, IHC-P, ICC, IF, Flow HU RF16025PD-L1 Antibody [4F2] Mouse IgG1
E, WB, IHC-P, ICC, IF, Flow HU RF16031PD-L1 Antibody [8E12] Mouse
IgG1 E, WB, IHC-P, ICC, IF, Flow HU RF16032PD-L1 Antibody [6H10]
Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16035PD-L1 Antibody [2D6]
Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16036PD-L1 Antibody [1F11]
Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16037PD-L1 Antibody [1D7]
Mouse IgG1 E, WB, IHC-P, ICC, IF HU RF16038CD80 Antibody [8G12]
Mouse IgG2b E, IHC-P, ICC, IF, Flow HU RF16041
CD80 Antibody [10A1] Mouse IgG2b E, IHC-P, ICC, IF, Flow HU
RF16042CD80 Antibody [7A2] Mouse IgG1 E, IHC-P, ICC, IF, Flow HU
RF16043CD80 Antibody [11D1] Mouse IgG1 E, IHC-P, ICC, IF, Flow HU
RF16044CD80 Antibody [11C12] Mouse IgG1 E, WB, IHC-P, ICC, IF HU
RF16045CD80 Antibody [12D9] Mouse IgG1 E, WB, IHC-P, ICC, IF HU
RF16046
Risk-Free lmmune Checkpoints
Risk-Free Features & Benefits
Recognize native human proteins
Rigorously characterized & guaranteed high performance
Matched ELISA pairs & detection sets for your specific
application
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IMMUNE CHECKPOINTSprosci-inc.com/immune-checkpoint 5
Product Name Host Isotype Application Reactivity Cat. No.TIGIT
Antibody [7E5] Mouse IgG2b E, IHC-P, ICC, IF, Flow HU RF16051TIGIT
Antibody [3B5] Mouse IgG2a E, IHC-P, ICC, IF, Flow HU RF16053TIGIT
Antibody [4A10] Mouse IgG1 E, WB, IHC-P, ICC, IF, Flow HU
RF16054TIGIT Antibody [4A11] Mouse IgG1 E, WB, IHC-P, ICC, IF, Flow
HU RF16055TIGIT Antibody [4A12] Mouse IgG1 E, WB, IHC-P, ICC, IF,
Flow HU RF16056TIGIT Antibody [10B1] Mouse IgG1 E, IHC-P, ICC, IF,
Flow HU RF16058LIGHT Antibody [7B9F12] Mouse IgG2b E, WB, IHC-P,
ICC, IF, Flow HU RF16061LIGHT Antibody [7B9H9] Mouse IgG2b E, WB,
IHC-P, ICC, IF, Flow HU RF16062LIGHT Antibody [7B9E12] Mouse IgG2b
E, WB, IHC-P, ICC, IF, Flow HU RF16063LIGHT Antibody [8D4] Mouse
IgG2b E, WB, IHC-P, ICC, IF, Flow HU RF16064VISTA Antibody [4C4]
Mouse IgG1 E, WB, IHC-P, ICC, IF, Flow HU RF16071VISTA Antibody
[6D2] Mouse IgG1 E, IHC-P, ICC, IF, Flow HU RF16072VISTA Antibody
[8E11] Mouse IgG1 E, IHC-P, ICC, IF, Flow HU RF16073VISTA Antibody
[9E4] Mouse IgG2b E, IHC-P, ICC, IF, Flow HU RF16074LAG-3 Antibody
[2G8] Mouse IgG1,k E, WB, IHC-P, ICC, IF, Flow HU RF16082LAG-3
Antibody [7A7] Mouse IgG2a,k E, ICC, Flow HU RF16083LAG-3 Antibody
[9F9] Mouse IgG2a,k E, IHC-P, ICC, IF, Flow HU RF16084LAG-3
Antibody [6B12] Mouse IgG1,k IHC-P, ICC, IF HU RF16086LAG-3
Antibody [6D1] Mouse IgG1,k IHC-P, ICC, IF HU RF16087LAG-3 Antibody
[5F11] Mouse IgG1,k E, WB, IHC-P, ICC, IF, Flow HU RF16088LAG-3
Antibody [1G4] Mouse IgG1,k E, WB, IHC-P, ICC, IF, Flow HU
RF16089B7-H3 Antibody [2H5] Mouse IgG1,k E, WB, IHC-P, ICC, IF,
Flow HU RF16091
B7-H3 Antibody [2A7] Mouse IgG1,k E, WB, IHC-P, ICC, IF, Flow HU
RF16092
B7-H3 Antibody [4H3] Mouse IgG1,k E, WB, IHC-P, ICC, IF, Flow HU
RF16093B7-H3 Antibody [7B3] Mouse IgG1,k E, IHC-P, ICC, IF, Flow HU
RF16094B7-H3 Antibody [10G6] Mouse IgG1,k E, IHC-P, ICC, IF, Flow
HU RF16095TIM-3 Antibody [10C10] Mouse IgG1,k E, WB, IHC-P, ICC,
IF, Flow HU RF16103TIM-3 Antibody [1H4] Mouse IgG1,k E, ICC, Flow
HU RF16104TIM-3 Antibody [3G7] Mouse IgG1,k E, IHC-P, ICC, IF, Flow
HU RF16105TIM-3 Antibody [2A6] Mouse IgG1,k E, WB, IHC-P, ICC, IF,
Flow HU RF16106TIM-3 Antibody [1B10] Mouse IgG1,k E, WB, IHC-P,
ICC, IF, Flow HU RF16107TIM-3 Antibody [1C6] Mouse IgG2b,k E,
IHC-P, ICC, IF, Flow HU RF16108TIM-3 Antibody [9G1] Mouse IgG2b,k
E, IHC-P, ICC, IF, Flow HU RF16109TMIGD2 Antibody [8A1] Mouse
IgG1,k E, WB, ICC, IF, IHC-P, Flow HU RF16121TMIGD2 Antibody [8G1]
Mouse IgG1,k E, WB, ICC, IF, IHC-P HU RF16122TMIGD2 Antibody [7A10]
Mouse IgG1,k ICC, IF, IHC-P HU RF16123
Risk-Free lmmune Checkpoints
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6PRODUCTSprosci-inc.com/products
Product Name Species Tissue/Cell Cat. No.THP-1 Lysate Human Cell
RF10001-01HEK293 Lysate Human Cell RF10001-02Human Spleen Lysate
Human Tissue RF10001-03Human Tonsil Lysate Human Tissue
RF10001-04Human Lymph Node Lysate Human Tissue RF10001-05Raji
Lysate Human Cell RF10001-06
Lysates
Product Name Species Tissue/Cell Cat. No.THP-1 Cell Slide Human
Cell RF10002-01HEK293 Cell Slide Human Cell RF10002-02Spleen Tissue
Slide (Normal) Human Tissue RF10002-03Raji Cell Slide Human Tissue
RF10002-04Stomach Tissue Slide (Malignant Tumor) Human Tissue
RF10002-05Colorectal Tissue Slide (Adenocarcinoma) Human Cell
RF10002-06
Slides
Product Name Species Cell Line Cat. No.PD-L1 Recombinant Protein
Human HEK293 RF16030-01CD273 Recombinant Protein Human HEK293
RF16020-01PD-1 Recombinant Protein Human HEK293 RF16000-01B7-H3
Recombinant Protein Human Human Cells RF16090-01CD80 recombinant
protein Human Human Cells RF16040-01CTLA-4 Recombinant Protein
Human HEK293 RF16010-01TMIGD2 Recombinant Protein Human Human Cells
RF16120-01LAG-3 Recombinant Protein Human Human Cells
RF16080-01B7-H5 Recombinant Protein Human HEK293 RF16070-01VSTM3
Recombinant Protein Human HEK293 RF16050-01LIGHT Recombinant
Protein Human Human Cells RF16060-01TIM-3 Recombinant Protein Human
HEK293 RF16100-01ICOSLG Recombinant Protein Human HEK293 96-047
Recombinant Proteins
Visit our website for more recombinant proteins, lysates, &
slides
Additional Products
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IMMUNE CHECKPOINTSprosci-inc.com/immune-checkpoint 7
Product Name Host Capture Cat No. Detection Cat. No. Reactivity
Set Cat. No.PD-1 ELISA MATCHED PAIR Mouse RF16004 RF16003-HRP HU
RFP-0001PD-1 ELISA MATCHED PAIR Mouse RF16005 RF16002-HRP HU
RFP-0002PD-1 ELISA MATCHED PAIR Mouse RF16006 RF16003-Biotin HU
RFP-0003PD-L1 ELISA MATCHED PAIR Mouse RF16031 SD8639 HU
RFP-0303PD-L1 ELISA MATCHED PAIR Mouse RF16032 SD8639 HU
RFP-0306PD-L1 ELISA MATCHED PAIR Mouse RF16038 RF16032-Biotin HU
RFP-0307CTLA-4 ELISA MATCHED PAIR Mouse RF16011 RF16013-HRP HU
RFP-0101CTLA-4 ELISA MATCHED PAIR Mouse RF16013 RF16011-HRP HU
RFP-0102TIGIT ELISA MATCHED PAIR Mouse RF16055 RF16058-Biotin HU
RFP-0501TIM-3 ELISA MATCHED PAIR Mouse RF16104 RF16103-Biotin HU
RFP-1001
Matched Pairs & Conjugates
ELISA Matched Pairs
Product Name Host Conjugate Application Cat. No.PD-1 Antibody
[8A4] (HRP) Mouse HRP ELISA RF16002-HRPPD-1 Antibody [7H6] (biotin)
Mouse Biotin ELISA RF16003-biotinPD-1 Antibody [7H6] (HRP) Mouse
HRP ELISA RF16003-HRPCTLA-4 Antibody [1E6] (HRP) Mouse HRP ELISA
RF16011-HRPCTLA-4 Antibody [8A1] (HRP) Mouse HRP ELISA
RF16013-HRPPD-L1 Antibody [8E12] (biotin) Mouse Biotin ELISA
RF16032-biotinTIGIT Antibody [10B1] (biotin) Mouse Biotin ELISA
RF16058-biotinTIM-3 Antibody [10C10] (biotin) Mouse Biotin ELISA
RF16103-biotin
Conjugates
TIGIT Pair Cat. No. RFP-0501
A sandwich ELISA was performed using the anti-TIGIT mAb
RF16055(5μg/ml) as the capture antibody.
Biotin-labeled anti-TIGIT maAb RF16058-biotin (1μg/ml) and
streptavidin-HRP(0.1μg/ml) were used for detection.
Detection range is from 10ng to 40pg.
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Product Name Host Clones Application Reactivity Cat. No.PD-1
Detection Set Mouse 5 E, WB, IHC-P, ICC, IF, Flow HU RF16000PD-L1
Detection Set Mouse 6 E, WB, IHC-P, ICC, IF, Flow HU RF16030CTLA-4
Detection Set Mouse 3 E, WB, IHC-P, ICC, IF HU RF16010PD-L2
Detection Set Mouse 5 E, WB, IHC-P, ICC, IF, Flow HU RF16020CD80
Detection Set Mouse 6 E, WB, IHC-P, ICC, IF, Flow HU RF16040TIGIT
Detection Set Mouse 6 E, WB, IHC-P, ICC, IF, Flow HU RF16050LIGHT
Detection Set Mouse 4 E, WB, IHC-P, ICC, IF, Flow HU RF16060VISTA
Detection Set Mouse 4 E, WB, IHC-P, ICC, IF, Flow HU RF16070LAG-3
Detection Set Mouse 7 E, WB, IHC-P, ICC, IF, Flow HU RF16080B7-H3
Detection Set Mouse 5 E, WB, IHC-P, ICC, IF, Flow HU RF16090TIM-3
Detection Set Mouse 7 E, WB, IHC-P, ICC, IF, Flow HU RF16100TMIGD2
Detection Set Mouse 3 E, WB, IHC-P, ICC, IF, Flow HU RF16120
PD-1 Single Domain Detection Set Llama 4 E, ICC, Flow HU
SD8600
Detection Sets
8RISK FREE SETSprosci-inc.com/risk-free-sets
Detection Sets
Features & BenefitsMultiple unique mAbs in a set
20μg sample size for testing
Select the best clone for your specific application
TIGIT mAb Set
Cat. No. ELISA WB ICC IF IHC Flow ELISA PairDetection
RF16051
RF16053 RF16058
RF16054 RF16058
RF16055 RF16058
RF16056 RF16058
RF16058 RF16053-RF16056
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The LatestAntibodyTechnology!
Recombinant monoclonal antibodies that can target unique
epitopes inaccessibleby conventional antibodies.
Single Domain AntibodiesConventional Antibody~150 kDa
Camelid Heavy Chain Antibody
~80 kDa
VHH or Single Domain Antibody
(sdAb)~15 kDa
llama
VH
CH
2
VL
CH
1C
L
CH
3
VHH
CH
2C
H3
VHH
VHH
Single Domain Antibodies
Product Name Host Isotype Application Reactivity Cat. No.PD-1
Antibody [F12A8] Llama sdAb E, Flow HU SD8643PD-1 Antibody [F42D7]
Llama sdAb E, Flow HU SD8645PD-1 Antibody [F34C9] Llama sdAb E,
Flow HU SD8647PD-1 Antibody [F25F4] Llama sdAb E, Flow HU
SD8649PD-L1 Antibody [F6A9] Llama sdAb ICC, Flow HU SD8639PD-L1
Antibody [F2G2] Llama sdAb E, ICC, Flow HU SD8641Single Domain
Negative Control [1H4] Llama sdAb E, IHC-P, ICC, IF, Flow HU
SD8733
• Smallest functional antibody unit (~15 kDa)• High affinity and
specificity• High solubility and stability• Lot to lot consistency•
Ideal for research, diagnostic, and therapeutic applications
Features & Benefits
PD-L1 sdAb Sandwich ELISACapture mAb RF16031
Coming SoonCTLA-4 TIGIT TIM-3 LAG-3 B7-H3 B7-H4 Your Target
IMMUNE CHECKPOINTSprosci-inc.com/immune-checkpoint 9
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CUSTOM ANTIBODY SERVICESprosci-inc.com/CAS 10
Custom Antibody Services
Additional Antibody Services
Polyclonal Antibodies Monoclonal Antibodies Single Domain
Antibodies
Species Available: Chicken Goat Rabbit Llama Mouse
Species Available:MouseRabbit
-Recombinant
Species Available:Llama
-Recombinant
Features & Benefits Quick turnaround High avidity Multiple
host species Useful for a variety of applications
Features & Benefits Features & Benefits Unlimited
quantity & availabiity Lot-to-lot consistency Quick
reproduction High specificity
~15 kDa antibody size Enhanced tissue penetration High affinity
& specificity Able to cross blood-brain barrier Binds small
cavities or clefts
Free Antigen Design AssistanceOptimize your antigen’s likelihood
to elicit an immune response & performance for
a desired antibody application.
Peptide Synthesis Conjugation Antibody Labeling Antibody
PurificationScales from milligram to grams
Purities from crude to >98%
Modifications: phosphorylation, methylation, acetylation &
more
SMCC
GLUT
EDC
HRP
Biotin
Protein A/G
Immuno-Affinity
IgY
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• Established in 1998
• Customizable services tailored to your needs
• In-house laboratories in San Diego, CA (USA)
• Animal facilities in San Diego, CA (USA)
• USDA licensed and NIH/OLAW assured animal facilities
• Over 20,000 custom antibody projects completed
• Over 30,000 catalog products to choose from
ver. 1
CORPORATE HEADQUARTERS
ProSci Incorporated12170 Flint PlacePoway, CA 92064USA
CONTACT INFORMATION
Toll Free: (888) 513 9525Local: (858) 513 2638Fax: E-Mail:
[email protected]
(858) 513 2692
20Years1998 - 2018
