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At Iasis Molecular Sciences, we are Advancing Patient Protection Against Infection by delivering prophylactic self-disinfection to any surface.
Infections are a Socioeconomic Burden Deadly & CostlyThe Problem:
Wound Infections (diabetic ulcers, burns & chronic wounds)• Infection (osteomyelitis) can lead to amputation• Diabetic ulcers ~$13B in annual healthcare costs• Large burns have high mortality rate (50-60%)
Healthcare-Associated Infections (HAIs)• Kill 100K annually, $50B+ recurring problem (U.S.)• Patients at risk: percutaneous devices & surgical sites• All clinical surfaces harbor pathogens
The Threat of Superbugs• Antibiotic resistance has severely
limited treatment options• New & improved antibiotics and/or
antiseptic agents are needed• U.S. GAIN Act created to promote
the development of new agents• Our compounds are highly effective
against many resistant organisms
Many solutions are ineffective and toxic to human tissue –resulting in recurring infections and slower wound healing.
Our Solution:Self-disinfecting materials for medical devices and surfaces in the clinical, consumer, and industrial environment to prevent healthcare-associated infections (HAIs) and to protect the general public from transmissible disease.
Addressing Evolving Problems
Traction: Ready for Translation
• Non-Dilutive Funding – 6 federal*, 3 local‐ NIH (NIGMS), DoD (CDMRP), and HSSA (Spokane)• Broad IP landscape (5 pending, 1 issued)• Academic collaborations (Virginia Commonwealth
University & Western University, Ontario, CA)• Washington Innovation Network (WIN) mentorship• Ignite Washington Accelerator Program member
*R43GM108378-01, R43GM109610-01A1, R43AI098214-01A1, R43GM103116-01, R43DK085957-01, W81XWH-11-2-0117 (DoD)
Contact Information
Spokane, WA
• David J. Vachon, CEO and President• Email: [email protected]• Phone: (509) 210-0736• Website: www.iasismolecular.com
Competitive Advantages:
1.E+00
1.E+01
1.E+02
1.E+03
1.E+04
1.E+05
1.E+06
1.E+07
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1.E+09
1.E+10
0 8 16 24 32
CFU
E. c
oli
pe
r m
m2
Hours of Exposure
Error bars are 95% confidence intervals
Bard Lubrisil ICGARDION™-AgGARDION™-Ag/CuControl (blank)
• Our antimicrobial agents surpass industry standards across the board (exceptional performance, low cost, and easy to implement)
• GARDION™-modified silicones outperform BARD LUBRI-SIL®Infection Control urinary catheters
LUBRI-SIL® IC Foley catheter relies on a fragile & costly nanoparticle coating (Bactiguard: Ag alloy)
whereas our silicone materials are antimicrobial through-and-through
Bacterial reduction over time
• 1/100th the cost of silver nanoparticles
• Active at low loading • Process stable• Long-term, controlled
release • Able to deliver multiple
agents simultaneously• Green synthesis• Through-and-through
antimicrobial protection
LUBRI-SIL® IC Foley catheter
Novion GARDION
Silver Zeolites
Ag+ & Ag0
Antiseptics
Antibiotics
Surface Mod.
Co
st
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icro
bia
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Bio
com
pat
ible
Res
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nce
Stab
ility
Ap
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Best =
Good =
Fair =
Poor =
Novion GARDION
Silver Zeolites
Ag+ & Ag0
Antiseptics
Antibiotics
Surface Mod.
Co
st
An
tim
icro
bia
l
Bio
com
pat
ible
Res
ista
nce
Stab
ility
Ap
plic
atio
ns
Du
rati
on
Co
smet
ics
Best =
Good =
Fair =
Poor =
IASIS GARDION™
• Our derivatives do not interrupt foaming reactions (in silicone and polyurethane foams)
• Copper (Cu) and benzalkonium (BA) paints are highly effective at low loadings (2 wt% and less)
GARDION™ Antimicrobials:
• GARDION™ biocides can be incorporated into nearly any synthetic material without adversely affecting mechanical properties
• Medical, consumer, and industrial applications• Imparts through-and-through antimicrobial activity• Can be used to modify bulk materials or advanced coatings• Ion-mediated controlled-release mechanism• Green synthesis (all aqueous)• Stable to processing conditions (200°C+)• Eradicates up to 99.999+% of pathogens• Low toxicity, excellent biocompatibility
GARDION™ powders
Ion-Exchange Platform
foams
hydrogels
paints
silicones
Composites do not swell or become porous
Easily processed into synthetic materials to create materials that are antimicrobial through-and-throughGARDION™ surfaces
liberate active ions via ion-exchange in biological fluids
epoxies
acrylics
GARDION™ Antimicrobials create self-disinfecting surfaces
1 cm1 cm
S. aureus K. pneumoniae Polyurethane hydrogel coatings with
GARDION™-Ag prevent growth of gram-positive and gram-negative
pathogens (Kirby-Bauer).
Surface E. coli S. epidermidis S. aureus E. faecalis K. pneumoniae P. aeruginosa
BA-SC 2% Ø 99.8771 99.9998 99.5853 Ø Ø
Cu-SC 0.75 % 99.9998 99.9998 99.9998 99.8578 99.9998 99.9688
Cu-SC 1.5% 99.9998 99.9998 99.9998 99.9998 99.9998 99.9998
Cu-WC 0.75% 99.9998 99.9945 99.9998 99.4807 99.9998 99.9908
Cu-WC 1.5% 99.9998 99.9998 99.9998 99.9998 99.9998 99.9998
% CFU Reduction
Copper (II) addition to water-based, low-VOC paints is unique to the industry as copper typically causes coagulation.
Hydrogel Coatings
GARDION™ Paints
Performance, Cost, & Implementation
