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Hyperkinetic Movement Disorders: Symposium Co-Sponsored by the Parkinson Study Group
and Movement Disorder Society Sunday, October 14, 1990
Grand Ballroom A, Hilton Hotel, Atlanta, GA
Program
1:3O
1:3O -1:45
1 :45 -2:00
2:OO -2:lS
2:15 -2:3O
2:3O -2:45
2:45 -3:OO
3:OO -3:lS
3:15 -3 :.? 0
3:3O -3:45
3:45 -4:00
4:OO -4:IS
4:15 -4:3O
Introduction Koller
Evaluation of Early Brain Changes in Corticobasal Ganglionic Degeneration Wilson
SPECT in Corticobasal Degeneration Golbe
Jaw Tremor with Severe Dysarthria: A Variant of Essential Tremor Ranaway a
Quantitative Analysis of Tremor and Chorea Using the VPL Data Glove Will
Adult Manifestations of Gilles de la Tourette’s Syndrome Goetz
A Controlled Trial of Propoxyphene and Naltrexone in Tourette’s Syndrome: Preliminary Results Kurlan
Treatment of Paroxysmal Dystonia in Multiple Sclerosis with Acetazolamide Sethi
Familial Torsion Dystonia and Cerebellar Ataxia: Variable Phenotypes in a Family Adlw
Break
G5HTP Is Not Useful in Cerebellar Syndromes Singer
Extraneural Metabolism in Early Huntington’s Disease O’Brien
AIDS Dementia Complex Presenting As an Unusual Unilateral Hand Tremor, Clumsiness, and Posturing Singer
4:30 Postencephalitic Movement Disorder With -4:45 Spontaneous Remission
Perlnzutter
4:45 Dilantin-induced Dyskinesia -5:00 Hawison
Abstracts
Evaluation of Early Brain Changes in Corticobasal Ganglionic Degeneration R. E. Wilson, S. Bums, R. M. Kdem, K. Shannon, and W. 0. Whetsell, Jr, Nashville, T N Corticobasal ganglionic degeneration (CBGD) is a neurode- generative disease that presents with asymmetrical akinesia, rigidity, and apraxia. Postmortem examination (8 reported cases) typically reveals widespread cortical neuronal dropout as well as involvement of the basal ganglion. We present the case of a 64-year-old woman with a I-year history of im- paired right-hand dexterity following 8 years of left-hand dystonia. Her memory and verbal skills were normal. She had ideational apraxia and left cortical sensory loss. Magnetic resonance imaging (MRI) showed atrophy of the right sen- sorimotor cortex and symmetrical enlargement of the third and lateral ventricles. Positron emission tomography (PET) scan showed glucose hypometabolism in the atrophic cortex, but the reduction was more extensive than indicated by MRI. The right basal ganghon was hypometabolic but the basal ganglia were anatomically symmetrical. A right frontal brain biopsy was normal. Baclofen mildly reduced left arm tone. This is the first report of brain biopsy in a patient with clinically diagnosed CBGD. In this case cerebral histological findings were normal even though clinical symptoms and glucose uptake indicate functional abnormality. The func- tional cortical alteration that precedes detectable morpholog- ical change may give rise to subcortical changes as a conse- quence of altered corticobasal ganglionic projections. The etiology of the functional change is unknown.
Single-photon Emission Computed Tomography Imaging in Corticobasal Degeneration L. I . Golbe, New Brunswick, NJ Corticobasal degeneration (CBD) is generally an autopsy diagnosis. Only 7 cases have been reported in detail and
298 Annals of Neurology Vol 28 No 2 August 1990