wwwMedChemExpresscom 1

Histamine Receptor

Histamine Receptors are a class of G protein-coupled receptors withhistamine as their endogenous ligand There are four knownhistamine receptors H1 receptor H2 receptor H3 receptor H4receptor The H1 receptor is a histamine receptor belonging to thefamily of Rhodopsin-like G-protein-coupled receptors This receptorwhich is activated by the biogenic amine histamine is expressedthroughout the body to be specific in smooth muscles on vascularendothelial cells in the heart and in the central nervous system H2receptors are positively coupled to adenylate cyclase via Gs It is apotent stimulant of cAMP production which leads to activation ofProtein Kinase A Histamine H3 receptors are expressed in the central

nervous system and to a lesser extent the peripheral nervous system where they act asautoreceptors in presynaptichistaminergic neurons and also control histamine turnover by feedback inhibition of histamine synthesis and releaseThe Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cellchemotaxis

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9936Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9717Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9800Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9894Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Histamine Receptor Inhibitors amp Modulators

Bioactivity (plusmn)-Methotrimeprazine (D6) is the deuterium labeledMethotrimeprazine which is a D3 dopamine and Histamine H1receptor antagonist

Bioactivity (plusmn)-Tazifylline is a potent selective and long-acting antagonisthistamine H1 receptor

Bioactivity ABT-239 is a novel highly efficaciousnon-imidazole class of antagonist and a transientH3Rreceptor potential vanilloid type 1 ( )TRPV1antagonist

Bioactivity Acrivastine (BW825C) is a short acting histamine 1receptor antagonist for the treatment of allergic rhinitis

Bioactivity Alcaftadine(R89674) is a H1 histamine receptor antagonistwhich is used to prevent eye irritation brought on by allergicconjunctivitis

Bioactivity Alimemazine D6 is deuterium labeled Alimemazine which is anantihistamine

Bioactivity Antazoline hydrochloride is a 1st generation antihistaminewith also anticholinergic properties used to relieve nasalcongestion and in eye drops

Bioactivity Antihistamine-1 is a ( =69 nM) withH1-antihistamine Kiacceptable blood-brain barrier penetration and also aninhibitor of and with s of 54 andCYP2D6 hERG channel IC5008 μM respectively

Bioactivity Astemizole a second-generation antihistamine drug to diminishallergic symptoms with a long duration of action is a

antagonist with an of 4 nMhistamine H1-receptor IC50Astemizole also shows potent hERG K+ channel blocking activhellip

Bioactivity Azatadine is an histamine and cholinergic inhibitor with IC50of 65 nM and 10 nM respectively Target Histamine ReceptorAzatadine a new antihistamine was evaluated for its efficacyin 20 patients with chronic allergic rhinitis Eighty percentof patients had symptomatic relief with a twice daily dosagehellip

2 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

(plusmn)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) Cat No HY-19489S

(plusmn)-Tazifylline Cat No HY-U00018

ABT-239 Cat No HY-12195

Acrivastine (BW825C) Cat No HY-B1510

Alcaftadine (R89674) Cat No HY-17039

Alimemazine D6 (Trimeprazine D6) Cat No HY-12752S

Antazoline hydrochloride (Phenazoline hydrochloride) Cat No HY-B1067

Antihistamine-1 Cat No HY-100238

Astemizole (R 43512) Cat No HY-12532

Azatadine Cat No HY-B0170

wwwMedChemExpresscom 3

Purity 9995Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in Water

1 g 5 g 10 g

Purity 9936Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9977Clinical Data Phase 2Size 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 2Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 2Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9995Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Azatadine dimaleate is an histamine and cholinergic inhibitorwith IC50 of 65 nM and 10 nM respectively Target HistamineReceptor Azatadine a new antihistamine was evaluated for itsefficacy in 20 patients with chronic allergic rhinitis Eightypercent of patients had symptomatic relief with a twice dailyhellip

Bioactivity Azelastine is a potent second-generation selectivehistamine antagonist

Bioactivity Azelastine HCl is a potent second-generation selectivehistamine antagonist

Bioactivity Bamirastine inhibits ligand binding to recombinant humanhistamine H receptors ( ) with an value of 1731 rhH R1 IC50nM

Bioactivity Bavisant (JNJ-31001074) is a highly selective orally activeantagonist of the human H3 receptor with a novel mechanism ofaction involving wakefulness and cognition with potential asa treatment for ADHD

Bioactivity Bavisant Hcl (JNJ-31001074) is a highly selective orallyactive antagonist of the human H3 receptor with a novelmechanism of action involving wakefulness and cognition withpotential as a treatment for ADHD

Bioactivity Bavisant Hcl hydrate(JNJ-31001074) is a highly selectiveorally active antagonist of the human H3 receptor with a novelmechanism of action involving wakefulness and cognition withpotential as a treatment for ADHD

Bioactivity Bepotastine Beslilate (Bepreve) is a histamine H1 receptoranatagonist

Bioactivity Betahistine Dihydrochloride is a histamine H3 receptorsinhibitor used as an antivertigo drug

Bioactivity Bilastine is a selective histamine H1 receptor antagonist usedfor treatment of allergic rhinoconjunctivitis and urticaria

Azatadine dimaleate (Azatadine maleate) Cat No HY-B0170A

Azelastine Cat No HY-B0462A

Azelastine hydrochloride Cat No HY-B0462

Bamirastine (TAK-427) Cat No HY-101601

Bavisant (JNJ-31001074) Cat No HY-14880

Bavisant dihydrochloride Cat No HY-14880A

Bavisant dihydrochloride hydrate (JNJ31001074AAC) Cat No HY-14880B

Bepotastine Beslilate Cat No HY-A0015

Betahistine dihydrochloride Cat No HY-B0524A

Bilastine Cat No HY-14447

Purity 9991Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9930Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9917Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Purity 9978Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg 500 mg

Purity 9995Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Bioactivity BMY-25271 is a antagonisthistamine H2 receptor Bioactivity Brompheniramine maleate is a histamine H1 receptorsantagonist

Bioactivity Carbinoxamine maleate salt is a histamine H1 receptorantagonist

Bioactivity Cetirizine a second-generation antihistamine is a majormetabolite of hydroxyzine and a racemic selective H1 receptorinverse agonist used in the treatment of allergies hay feverangioedema and urticaria IC50 value Target Histamine H1receptor Cetirizine crosses the blood-brain barrier onlyhellip

Bioactivity Cetirizine D4 2Hcl is deuterium labeled Cetirizine which is amajor metabolite of hydroxyzine and a racemic selective H1receptor inverse agonist

Bioactivity Cetirizine D8 2Hcl is deuterium labeled Cetirizine which is amajor metabolite of hydroxyzine and a racemic selective H1receptor inverse agonist

Bioactivity Cetirizine 2Hcl a second-generation antihistamine is a majormetabolite of hydroxyzine and a racemic selective H1 receptorinverse agonist used in the treatment of allergies hay feverangioedema and urticaria IC50 value Target Histamine H1receptor Cetirizine crosses the blood-brain barrier onlyhellip

Bioactivity Chlorcyclizine hydrochloride is a antagonisthistamine H1

Bioactivity Chloropyramine hydrochloride is a histamine receptor H1antagonist which can also inhibit the biochemical function of

and VEGFR-3 FAK

Bioactivity Chlorpheniramine maleate is an histamine H1 receptorantagonist with IC50 of 12 nM

4 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

BMY-25271 Cat No HY-100191

Brompheniramine maleate Cat No HY-B0480

Carbinoxamine maleate salt Cat No HY-B1589A

Cetirizine Cat No HY-17042

Cetirizine D4 dihydrochloride Cat No HY-17042AS

Cetirizine D8 dihydrochloride Cat No HY-17042AS1

Cetirizine dihydrochloride (P071) Cat No HY-17042A

Chlorcyclizine hydrochloride Cat No HY-112067A

Chloropyramine hydrochloride Cat No HY-B1305

Chlorpheniramine maleate (Chlorphenamine maleate) Cat No HY-B0286A

wwwMedChemExpresscom 5

Purity 9932Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg

Purity 9982Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9956Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 980Clinical Data LaunchedSize 1 g 5 g 10 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9509Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Bioactivity Chlorphenoxamine is an antihistamine and anticholinergic usedas an antipruritic and antiparkinsonian agent

Bioactivity CI-949 is an allergic mediator release inhibitor whichinhibits andhistamine leukotriene C D ( )4 4 LTC4 LTD4

release with s of 114 μM 05thromboxane B ( )2 TXB2 IC50μM and 01 μM respectively

Bioactivity Cimetidine is a histamine-2 (H2) receptor antagonist Bioactivity Cinnarizine is an antihistamine and a calcium channel blockerpromote cerebral blood flow used to treat cerebral apoplexypost-trauma cerebral symptoms and cerebral arteriosclerosis

Bioactivity Cipralisant is a potent and selective histamine H3 antagonist in vivo and an agonist in vitro with areceptor

of 99 for histamine H3 receptor and a of 047 nM forpKi Kirat histamine H3 receptor Cipralisant has entered in clinicaltrials for the treatment of attention-deficit hyperactivityhellip

Bioactivity Ciproxifan(FUB-359) is a highly potent and selective histaminH3-receptor antagonist with IC50 of 92 nM with low apparentaffinity at other receptor subtypes

Bioactivity Ciproxifan maleate(FUB-359 maleate) is a highly potent andselective histamin H3-receptor antagonist with IC50 of 92 nMwith low apparent affinity at other receptor subtypes

Bioactivity Clemastine (fumarate) (HS-592 (fumarate)) is a selectivehistamine H1 receptor antagonist with IC of 3 nM50

Bioactivity Clemizole is an antagonist is foundH1 histamine receptorto substantially inhibit replication The ofHCV IC50Clemizole for RNA binding by is 24plusmn1 nM whereas itsNS4B

for viral replication is 8 microMEC50

Bioactivity Clemizole hydrochloride is an H1 histamine receptorantagonist is found to substantially inhibit HCVreplication The of Clemizole for RNA binding by isIC50 NS4B

24plusmn1 nM whereas its for viral replication is 8 microMEC50

Chlorphenoxamine Cat No HY-B1607

CI-949 Cat No HY-U00364

Cimetidine (SKF-92334) Cat No HY-14289

Cinnarizine Cat No HY-B1090

Cipralisant (GT-2331) Cat No HY-106993

Ciproxifan (FUB-359) Cat No HY-14567

Ciproxifan maleate (FUB 359 maleate) Cat No HY-15289

Clemastine fumarate (HS-592 (fumarate) Meclastine (fumarate)) Cat No HY-B0298A

Clemizole Cat No HY-30234

Clemizole hydrochloride Cat No HY-30234A

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9902Clinical Data LaunchedSize 10mM x 1mL in Water

1 g

Purity 9975Clinical Data LaunchedSize 10mM x 1mL in DMSO

250 mg 500 mg 5 g

Purity 9989Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

200 mg

Purity 9975Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 500 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 500 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg 500 mg

Purity 9920Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity CP-66948 is a antagonist withhistamine H2-receptorgastric antisecretory activity and mucosal protectiveproperties

Bioactivity Cyproheptadine hydrochloride sesquihydrate is an antihistamineand is an antagonist of serotonin and histamine2

Bioactivity Decloxizine(UCB-1402 NSC289116) is a histamine 1 receptorantagonist

Bioactivity Decloxizine dihydrochloride(UCB-1402 NSC289116) is ahistamine 1 receptor antagonist

Bioactivity Desloratadine(Sch34117) is a potent antagonist for humanhistamine H1 receptor used to treat allergies

Bioactivity Dexchlorpheniramine maleate is an antihistamine withanticholinergic properties used to treat allergic conditions

Bioactivity Dimenhydrinate is an anti-emetic and anti-histamine commonlyavailable over-the-counter as a motion sickness remedy

Bioactivity Diphenhydramine HCl (Benadryl) a histamine H1 antagonist usedas an antiemetic antitussive for dermatoses and pruritusfor hypersensitivity reactions as a hypnotic anantiparkinson and as an ingredient in common coldpreparations Target Histamine H1 receptor Diphenhydraminehellip

Bioactivity Diphenylpyraline Hcl is a first-generation antihistamine withanticholinergic effects acts as a dopamine reuptakeinhibitor shows to be useful in the treatment ofParkinsonism

Bioactivity Doxylamine D5 succinate is deuterium labeled Doxylamine whichis a first generation antihistamine

6 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

CP-66948 Cat No HY-19048

Cyproheptadine hydrochloride sesquihydrate Cat No HY-B1165

Decloxizine (UCB-1402 NSC289116) Cat No HY-17582

Decloxizine dihydrochloride (UCB 1402 dihydrochloride) Cat No HY-A0075

Desloratadine (Sch34117) Cat No HY-B0539

Dexchlorpheniramine maleate (S-(+)-Chlorpheniramine maleate salt) Cat No HY-B1062

Dimenhydrinate Cat No HY-B1215

Diphenhydramine hydrochloride Cat No HY-B0303A

Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) Cat No HY-B0970

Doxylamine D5 succinate Cat No HY-A0069S

wwwMedChemExpresscom 7

Purity 9858Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9961Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9903Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9817Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 500 mg

Purity 9778Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity 9996Clinical Data Phase 4Size 10mM x 1mL in Ethanol

500 mg 1 g 5 g

Purity 9977Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Bioactivity Doxylamine (succinate) is a first generation antihistaminecan be used by itself as a short-term sedative and incombination with other drugs to provide night-time allergy andcold relief

Bioactivity Ebastine(LAS-W 090RP64305) is a long-acting and selectiveH1-histamine receptor antagonist Target Histamine H1Receptor Ebastine is a H1 antihistamine with low potential forcausing drowsiness Ebastine (10 mg orally) causes brainhistamine H1-receptor occupation of approximately 10hellip

Bioactivity Ebrotidine(FI 3542) is a competitive H2-receptor antagonist(Ki= 1275 nM) with a potent antisecretory activity andevidenced gastroprotection

Bioactivity Epinastine(WAL801) is an antihistamine and mast cellstabilizer that is used in eye drops to treat allergicconjunctivitis

Bioactivity Famotidine (MK-208) is a competitive histamine H2-receptorantagonist Its main pharmacodynamic effect is the inhibitionof gastric secretion

Bioactivity Fenspiride Hcl is an α adrenergic and H1 histamine receptorantagonist

Bioactivity Fexofenadine D6 is deuterium labeled is Fexofenadine which isan antihistamine pharmaceutical drug

Bioactivity Fexofenadine hydrochloride (MDL-16455 hydrochlorideTerfenidine carboxylate hydrochloride) a antagonist isH1Ran anti-allergic agent used in seasonal allergic rhinitis andchronic idiopathic urticarial (person aged ge16 years) [1]

Bioactivity FRG-8701 is a new antagonist withHistamine H -receptor2an of ranging from 025 to 043 μMIC50

Bioactivity GSK189254A (GSK189254) is a novel potent and selectivehistamine receptor antagonist with values of 959-990H3 pKiand 851-917 for human and rat H3 respectively

Doxylamine succinate Cat No HY-A0069

Ebastine (LAS-W 090 RP64305) Cat No HY-B0674

Ebrotidine (FI3542) Cat No HY-15538

Epinastine (WAL801) Cat No HY-B0640

Famotidine (MK-208) Cat No HY-B0377

Fenspiride Hydrochloride Cat No HY-A0027

Fexofenadine D6 (MDL-16455 D6) Cat No HY-B0801S

Fexofenadine hydrochloride (MDL-16455 hydrochloride

Terfenidine carboxylate hydrochloride) Cat No HY-B0801A

FRG8701 Cat No HY-U00238

GSK189254A Cat No HY-14111

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity 9979Clinical Data LaunchedSize 10mM x 1mL in Water

1 g

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9552Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity H3 receptor antagonist 1 is an antagonist of histamine H3 used in the research of neurological diseasereceptor

Bioactivity H3 receptor-MO-1 is a modulator of histamine H3 receptor

Bioactivity H3R-IN-1 Hydrochloride is a ( )histamine receptor 3 H3Rinverse agonist extracted from patent WO2013107336A1 compoundexample 2

Bioactivity H4 Receptor antagonist 1 is a potent and selective inverse agonist with an of 19histamine H4 receptor IC50

nM

Bioactivity H4R antagonist 1 is a potent and highly selective histamine ( ) antagonist with an IC of 27 nM H4RH4 receptor H4R 50

antagonist 1 does not show any noticeable binding affinityhellip

Bioactivity Histamine is an organic nitrogenous compound involved in localimmune responses as well as regulating physiological functionin the gut and acting as a neurotransmitter

Bioactivity Histamine diphosphate is a potent agonist of histaminereceptors and vasodilator It can activate nitric oxidesynthetase

Bioactivity Hydroxyzine is a histamine H1-receptor antagonist

Bioactivity Hydroxyzine D4 2Hcl is deuterium labeled Hydroxyzine which isa histamine H1-receptor antagonist

Bioactivity Hydroxyzine Dihydrochloride is a histamine H1-receptorantagonist Target Histamine H1-Receptor Hydroxyzine inhibitscarbachol (10 μM)-induced serotonin release by 34 at 10 μMby 25 1 μM and by 17 01 μM in pretreated bladder slices for60 min [1] Hydroxyzine (01 mM) treatment inhibits thehellip

8 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

H3 receptor antagonist 1 Cat No HY-U00269

H3 receptor-MO-1 Cat No HY-U00339

H3R-IN-1 Hydrochloride Cat No HY-112219A

H4 Receptor antagonist 1 Cat No HY-114025

H4R antagonist 1 Cat No HY-111501

Histamine (Ergamine) Cat No HY-B1204

Histamine phosphate (Histamine diphosphate) Cat No HY-A0129

Hydroxyzine Cat No HY-B0548

Hydroxyzine D4 dihydrochloride Cat No HY-B0548AS

Hydroxyzine dihydrochloride Cat No HY-B0548A

wwwMedChemExpresscom 9

Purity 9800Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg 200 mg

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9975Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg 200 mg

Purity 9786Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

200 mg 1 g

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 100 mg

Bioactivity Hydroxyzine pamoate is a histamine H1-receptor antagonistTarget Histamine H1-Receptor Hydroxyzine inhibits carbachol(10 μM)-induced serotonin release by 34 at 10 μM by 25 1 μMand by 17 01 μM in pretreated bladder slices for 60 min [1]Hydroxyzine (01 mM) treatment inhibits the progression andhellip

Bioactivity JNJ-39758979 is a selective high-affinity histamine H4 antagonist with a of 125 nMreceptor Ki

Bioactivity JNJ-5207852 is a selective and potent histamine H3receptor (H R) antagonist with of 89 924 for rat3 pK siand human H R respectively3

Bioactivity JNJ-7777120 is a selective H4R antagonist with Ki of 4 plusmn1 nMexhibits gt1000-fold selectivity over the other histaminreceptors

Bioactivity Ketotifen (fumarate) is a second-generation noncompetitiveH1-antihistamine and mast cell stabilizer which is used toprevent asthma attacks

Bioactivity KP136 is an orally effective antiallergic agent The isIC50761 μgmL for and 63 ugmL forhistamine release

degranulation

Bioactivity Lafutidine a newly developed histamine H(2)-receptorantagonist inhibits gastric acid secretion

Bioactivity Latrepirdine dihydrochloride is a neuroactive compound withantagonist activity at histaminergic α-adrenergic andserotonergic receptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and ( )amyloid-β Aβsecretion

Bioactivity Levodropropizine (DF-526) is a histamine receptor inhibitorLevodropropizine is an effective and very well toleratedperipheral antitussive drug

Bioactivity Lodoxamide is an antiallergic compound acting as a mast-cellstabilizer for the treatment of asthma and allergicconjunctivitis

Hydroxyzine pamoate Cat No HY-B0895

JNJ-39758979 Cat No HY-101189

JNJ-5207852 Cat No HY-12190

JNJ-7777120 Cat No HY-13508

Ketotifen fumarate (HC 20511 fumarate) Cat No HY-B0157A

KP136 (AL136) Cat No HY-U00168

Lafutidine (FRG-8813) Cat No HY-B0160

Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537

Levodropropizine (DF-526 (S)-(-)-Dropropizine) Cat No HY-B1895

Lodoxamide Cat No HY-14270

Purity 9979Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Purity 9731Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 990Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

100 mg

Purity 9997Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 5 g

Purity 9953Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9946Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9995Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 mg 5 mg

Bioactivity Lodoxamide tromethamine (U 42585 E) is a medication for thetreatment of prophylaxis of mast cell-mediated allergicdisease

Bioactivity Loratadine(SCH-29851) is a selective inverse peripheralhistamine H1-receptor agonist with an IC50 of gt32 μM IC50value 32 uM Target H1-receptor Loratadine is a non-sedativeantihistamine that inhibits histamine-induced activities ofIL-6 and IL-8 secretion in endothelial cells

Bioactivity Mebhydrolin is a specific histamine H receptor1antagonist

Bioactivity Mebhydrolin napadisylate is a specific histamine H1 antagonistreceptor

Bioactivity Meclizine is a histamine H1 receptor antagonist used to treatnausea and motion sickness Target Histamine H1 ReceptorMeclizine is a histamine H1 receptor antagonist used to treatnausea and motion sickness possesses anticholinergic centralnervous system depressant and local anesthetic effects [1]hellip

Bioactivity Mepyramine maleate a first generation antihistamine is anantagonist of with s of 08 nMhistamine H1 receptor Kd5200 nM and gt3000 nM for H1 H2 and H3 receptorrespectively and a of 94 for H1 receptorpKd

Bioactivity Mequitazine is a potent nonsedative and long-acting histamine antagonistH1

Bioactivity Metiamide (SKampF 92058) is a histamine H2-receptorantagonist developed from another H2 antagonist burimamide

Bioactivity Mianserin is a H1 receptor inverse agonist and is apsychoactive agent of the tetracyclic antidepressant

Bioactivity Mianserin hydrochloride is a H1 receptor inverse agonist andis a psychoactive agent of the tetracyclic antidepressantTarget H1 receptor Mianserin is a psychoactive drug of thetetracyclic antidepressant (TeCA) therapeutic family It isclassified as a noradrenergic and specific serotonergichellip

10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Lodoxamide tromethamine (U 42585 E) Cat No HY-16289

Loratadine (SCH 29851 Loratidine) Cat No HY-17043

Mebhydrolin Cat No HY-B1303A

Mebhydrolin napadisylate (Mebhydroline 15-naphthalenedisulfonate salt) Cat No HY-B1303

Meclizine dihydrochloride (Meclozine dihydrochloride NSC28728) Cat No HY-B0349

Mepyramine maleate (Pyrilamine maleate) Cat No HY-B1281

Mequitazine (LM-209) Cat No HY-B2168

Metiamide (SKamp F 92058) Cat No HY-15540

Mianserin (Mianserine) Cat No HY-B0188

Mianserin hydrochloride (Org GB 94) Cat No HY-B0188A

wwwMedChemExpresscom 11

Purity 9990Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

250 mg 1 g 5 g

Purity 9955Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9949Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9566Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9899Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data Phase 2Size 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Bioactivity Mizolastine is a histamine H1-receptor antagonist with IC50 of47 nM used in the treatment of hay fever (seasonal allergicrhinitis) hives and other allergic reactions

Bioactivity Mizolastine dihydrochloride is a histamine H1-receptorantagonist with IC50 of 47 nM used in the treatment of hayfever (seasonal allergic rhinitis) hives and other allergicreactions

Bioactivity MK-0249 is a potent antagonist withhistamine H3 receptor of 17 nM for human H3Ki

Bioactivity N-Acetylhistamine is a histamine metabolite N-acetylhistaminecan be used as a potential biomarker of histidine metabolismfor anaphylactoid reactions

Bioactivity Nedocromil suppresses the action or formation of multiplemediators including ( )histamine leukotriene C4 LTC4and ( )prostaglandin D2 PGD2

Bioactivity Nedocromil sodium suppresses the action or formation ofmultiple mediators including (histamine leukotriene C4

) and ( )LTC4 prostaglandin D2 PGD2

Bioactivity Niperotidine is a antagonisthistamine H2-receptor Bioactivity Nizatidine is a histamine H2 receptor antagonist with lowtoxicity that inhibits gastric acid secretion

Bioactivity Olopatadine HCl is a histamine blocker used to treat allergicconjunctivitis

Bioactivity Osthole is a natural antihistamine alternative Osthole may bea potential inhibitor of activityhistamine H receptor1

Mizolastine Cat No HY-B0164

Mizolastine dihydrochloride Cat No HY-B0164A

MK-0249 Cat No HY-U00076

N-Acetylhistamine (N-Omega-acetylhistamine) Cat No HY-112175

Nedocromil (FPL 59002) Cat No HY-13448

Nedocromil sodium (FPL 59002KP Nedocromil disodium salt) Cat No HY-16344

Niperotidine Cat No HY-15539

Nizatidine Cat No HY-B0310

Olopatadine hydrochloride (ALO4943A KW4679) Cat No HY-B0426A

Osthole (NSC 31868 Osthol Ostol) Cat No HY-N0054

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Purity gt98Clinical Data LaunchedSize 10 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg 500 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9829Clinical Data No Development ReportedSize 500u g 1 mg 5 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg 100 mg

Bioactivity Pemirolast Potassium (BMY 26517) is a histamine H1 antagonistand mast cell stabilizer that acts as an antiallergic agentTarget Histamine H1 Receptor Pemirolast potassium (BMY 26517)is a new oral nonbronchodilator antiallergy medication thatis being evaluated for the therapy of asthma [1] Pemirolasthellip

Bioactivity Peptide 401 a potent mast cell degranulating factor from beevenom suppresses the increased vascular permeability due tointradermal injection of various smooth muscle spasmogens (

and )histamine 5-HT

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-3893787 hydrochloride is a novel histamine H4 receptorantagonist binding affinity ( =24 nM) and is also aKifunctional ( =156 nM) antagonistKi

Bioactivity Pheniramine Maleate ia an antihistamine and vasoconstrictor

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pirolate is a receptorhistamine H1 Bioactivity Pitolisant is a potent and selective nonimidazole inverseagonist at the recombinant human (histamine H3 receptor

=016 nM)Ki

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Pemirolast potassium (TWT-8152 BMY 26517) Cat No HY-B0538A

Peptide 401 Cat No HY-12537

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-3893787 hydrochloride Cat No HY-19705B

Pheniramine Maleate Cat No HY-B0971

Pimethixene (Pimetixene) Cat No HY-B1101

Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pirolate (CP-32387) Cat No HY-100280

Pitolisant (Tiprolisant) Cat No HY-12199

wwwMedChemExpresscom 13

Purity 950Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9902Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 50 mg 100 mg

Purity 9887Clinical Data LaunchedSize 10mM x 1mL in Water

1 g 5 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9948Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9982Clinical Data LaunchedSize 1 g 5 g

Purity gt98Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9922Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Pitolisant hydrochloride is a potent and selectivenonimidazole inverse agonist at the recombinant human

( =016 nM)histamine H3 receptor Ki

Bioactivity Pitolisant oxalate is a potent and selective nonimidazoleinverse agonist at the recombinant human histamine H3

( =016 nM)receptor Ki

Bioactivity Promethazine Hcl(NSC-231688) is the first-generationantihistamine strong antagonist of the H1 receptor andmoderate mACh receptor antagonist moderate affinity for5-HT2A 5-HT2C D2 and α1-adrenergic receptors

Bioactivity Quinotolast sodium in the concentration range of 1-100 μgmLinhibits and release in ahistamine LTC4 PGD2concentration-dependent manner

Bioactivity Ranitidine is a histamine H2-receptor antagonist that inhibitsstomach acid production

Bioactivity ReN 1869 hydrochloride is a novel selective histamine H1 antagonist which demonstrates affinity to thereceptor

histamine H receptor (guinea pig brain) with K of1 i019plusmn004 μM and the non-selective σ site (guinea pig brahellip

Bioactivity Rocastine is a selective nonsedating antagonist actingH1as an antihistamine

Bioactivity Roxatidine Acetate HCl is a specific and competitive histaminH2 receptor antagonist

Bioactivity S 38093 is a brain-penetrant antagonist of withH3 receptor of 88 144 and 12 microM for rat mouse and human H3Ki

receptors respectively

Bioactivity SUN 1334H is a potent orally active highly selective H1 antagonist with of 97 nMreceptor Ki

Pitolisant hydrochloride (Ciproxidine BF 2649) Cat No HY-12199B

Pitolisant oxalate (Tiprolisant oxalate) Cat No HY-12199A

Promethazine hydrochloride Cat No HY-B0781

Quinotolast sodium (FR71021) Cat No HY-U00027

Ranitidine hydrochloride Cat No HY-B0281A

ReN-1869 hydrochloride (NNC-05-1869 hydrochloride) Cat No HY-101724

Rocastine (AHR-11325) Cat No HY-101745

Roxatidine Acetate Hydrochloride (HOE 760) Cat No HY-B0305A

S 38093 Cat No HY-104003

SUN 1334H Cat No HY-U00084

Purity 990Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9837Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9987Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg 1 g 5 g

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Bioactivity Toreforant is a potent and selective histamine H receptor (4) antagonist with a at the human receptor of 84 nMH4R Ki

Bioactivity Tripelennamine Hcl a H1-receptor antagonist is apsychoactive drug and member of the pyridineandethylenediamine classes that is used as an antipruritic andfirst-generation antihistamine IC50 Value Target HistamineH1 receptor Tripelennamine can be used in the treatment ofhellip

Bioactivity VUF10460 is a non-imidazole histamine receptor agonistH4binds to rat H4 receptor with a of 746pKi

Bioactivity Wy 49051 is a potent orally active antagonistH1 receptorwith of 44 nMIC50

Bioactivity Zaltidine(CP-57361) is a H2-receptor antagonist which has theantisecretory action

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Toreforant (JNJ-38518168) Cat No HY-16756

Tripelennamine hydrochloride Cat No HY-17428

VUF10460 Cat No HY-101420

Wy 49051 Cat No HY-101830

Zaltidine (CP-57361) Cat No HY-15541