Heat Sealing - PCR Plates | Cell Screening Plates | Reaction Plates · 2016. 6. 6. · Fe56tdrTrsd edtt e rs nsdBrfds e it ntf12e 4rtdB3s Fechl Fels4sBSBpSs FeoOBgSBpSsg1ee46ssr eB12

Heat SealingHeat sealing is the gold standard plate sealing method, minimising sample loss and maximising sample security, for PCR, qPCR, storage and other applications.

IMAGES?

The sealing performance of heat seals is superior to cap, mat and adhesive sealing with clear reductions in sample loss and cross contamination. The optimized sealing performance allows use of smaller reaction volumes leading to reagent savings.

Heat sealing is the most cost efficient way to seal plates for a wide range of applications. Per well comparisons show a 3 to 5 five fold reduction in costs for qPCR application (list price comparison of Clear Weld Seal against caps and qPCR seal) and at least a 50% reduction for storage solutions (list price comparison of Peel Seal against caps and PCR seal). Costs can be further reduced by changing to use of the material format, using rolls rather than sheets.

The application of a heat seals is much faster than caps or adhesive seals. Typical sealing times are around 2,5 seconds. Depending on throughput the use of a semi-automatic or fully automatic heat sealer can guarantee a reproducible sealing quality by standardising the sealing parameters, time, temperature and pressure. Sealing performance variability between different users can be eliminated.

4titude® offers a wide choice of heat seals in both roll and sheet format. Different seals can be chosen to optimize the use depending on plate material, desired permeability or resistance, ability to peel or pierce the seal material and visualisation through the material. Please refer to the comparison table on page 73 for an overview of our heat sealing range.

All seals are certified free from nucleases and human genomic DNA contamination.

The best sealing results can be obtained by using flat, rigid plates with a raised rim design like our FrameStar® 2-component plates and reliable, high quality sealing instruments such as the 4s3 semi-automated heat sealer or the 4AS sealer.

For details of the instruments see page 62 and 64. For a demonstration or trial of a heat sealer please contact us at [email protected].

www.4ti.co.uk | 61 +44 (0)1306 884885 www.4ti.co.uk | 61 +44 (0)1306 884885

Hea

t Se

alin

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PEELABLE

A

UTOCLAVABLE

121o

ClearsealisanopticallyclearfilmwhichformsaneasilypeelableyetPCR/qPCRtightseal.Itsopticalclarityallowsuseforallopticalapplications.Theclearsealcanbeusedtosealmostplatetypesincludingpolypropylene,polyethylene,polystyreneandCOCplates.Availableassheetsoronarollforautomatedsealers.

Clear Seal

Applications

• qPCRorotheropticalapplications(e.g.fluorescenceorcolorimetricassays)

• Shorttermcompoundstorage

• Suitableformostplatematerials

• Availableinsheetorrollformatforautomatedsealers

• FreefromDNase,RNaseandhumangenomicDNA

Clearweldsealisanopticallyclearpolymerfilmwhichformsapermanentbondtopolypropyleneplatesthatcannotbepeeledandisdifficulttopierce.Thesealhasagoodsolventresistanceforsafelongtermstorage.

Samplecanbeaccessedifrequiredusingabladeorneedle.

NowalsoavailableasFrameSealproductseepage75

Clear Weld Seal Mark II

Applications

• PCR

• waterbaththermalcyclers

• qPCRandotheropticalapplications(e.g.fluorescenceandcolorimetricassays)

• Storageanddisposalofhazardousmaterials

• RecommendedforusewithDMSO

• Availableassheetsorinrollformatforautomatedsealers


*(110Cwithpressurisedheatedlid)

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-80°

80°

*

*Onceautoclaved,notrecommendedforPCRapplications

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-80°

110°

*

Code Pack Size/Dimensions

4ti-0573 610mx78mmroll1Approx5000seals

4ti-0573S Trialroll15mx78mm



4ti-0575 100sheets(125mmx78mm)

4ti-0575/FS SealingFrame:50seals/frameperpack



4ti-0540/REMP 500mx78mmroll3Approx4200seals




4ti-0542S Trialroll

4ti-0541 100sheets(125mmx78mm)5mx115mm

NEW

| www.4ti.co.uk66 +44 (0)1306 884885

Heat Sealing

TheClearSeal3730isaclearpolyesterbackedfilmwhichisparticularlythin.Itsealstopolypropylene,polystyrene,polyethyleneandCOCmicroplates.Thissealhasgoodopticalclaritywithmoderatesolventresistance.Thethinnatureofthissealenablesittobeeasilypiercedwithanauto-samplerneedle,ortheprobefromtheABi3730sequencer.

Thesealisonlyavailableinrollformat,butarollwithperforatedsheetscanbeusedforlowthroughput.

Clear Seal 3730

Applications

• PCR

• qPCRandotheropticalapplications(e.g.fluorescenceandcolorimetricassays)

• Piercablebyautosamplesneedles

• PiercablebytheABI3730

• Availableinrollformatforautomatedsealers


PIERCEABLE

ThispopularlaminatematerialgivesapeelableheatsealtoPPandCOCplates.Itcanbepeeleddirectlyfromtheplatefollowingremovalfromthefreezerandisagoodbarriertoaqueoussolutions.Thesealshowsmoderateresistancetosolventsatroomtemperatureandformsaweld-sealtopolyethyleneplates(cannotbepeeled).

Peel Seal

Applications

• Verylowtemperaturecompoundstorage.

• Mid-term(<5days)roomtemperaturecompoundstorage

• PCR

• Availableassheetsorinrollformatforautomatedsealers


1 Compatible with Thermo Fisher ALPS 300™ / ALPS 3000™ /

KBiosystems Wasp™ / KBioscience FlexiSeal and Cube2 Compatible with Agilent (Velocity 11) PlateLoc®

3 Compatible with REMP Portrait Heat Sealer (PHS)4 Compatible with REMP Landscape / Stacking Heat

Sealers (LHS/SHS)

COC = Cyclic Olefin Copolymer

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-20°

80°

*(110C with pressurised heated lid)

*

*(110CwithpressurisedPCRheatedlid)

A

UTOCLAVABLE

121o

PEELABLE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-200°

90°

*






4ti-0581 Rollof1000perforatedsheets125mmx78mm







www.4ti.co.uk | 67 +44 (0)1306 884885

Hea

t Se

alin

g

Pierce Seal

PEELABLE

ThislaminatematerialgivesapeelableheatsealtopolypropyleneandCOCplates.Itcanbepeeleddirectlyfromtheplateimmediatelyafterremovalfromthefreezer.TheDMSOresistantpeelsealisanexcellentbarriertoaqueoussolutionsandsolvents,inparticularDMSO,evenatroomtemperature.

Itformsaweld-sealtopolyethyleneplates(cannotbepeeled),requiringabladeorneedleforaccess.

DMSO Resistant Peel Seal

Applications

• LowandroomtemperaturecompoundstoragewithDMSO*andotherorganicsolvents

• 100%DMSOcanbestoredatroomtemperaturefor12monthswithnodeteriorationofthesealquality

• Availableinsheetandrollformatforautomatedsealers


Thisfoil-basedheatsealissuitablefortopolypropyleneandpolystyreneplatesandcanbeeasilypiercedwithamanualorautopipettetip.Ithasverygoodsolventresistance,includingtoDMSO.Sealscanbeappliedontopofeachotherallowingmultipleaccess/resealingofsamples.Abluecolourprintidentifiesthenon-sealingsurfaceforeaseofapplication.Thissealremainsintacttoveryhightemperatures.

Applications

• PCR

• LowandroomtemperaturecompoundstoragewithDMSOandotherorganicsolvents

• Sampleshipping



SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

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-80°

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A

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PIERCEABLE

SE

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R

ITY TEMPERATU

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E

-20°

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4ti-0530S Trialroll1



4ti-0532S Trialroll2


| www.4ti.co.uk68 +44 (0)1306 884885

Heat Sealing

TheINDISealisafoil-basedheatsealthatsealstopolypropyleneandissuitableforlowtemperaturestorage.Thesealconsistsof96perforatedindividualsealingcapsinafoilframe.Theframeisremovedafterheatsealingleavingeachwellwithanindividualairtightseal.Thesealshavetabsforeasyremovalbyhandorwithforceps,withoutleavinganyresidue.

Mainlydevelopedforusewithtubesinclusterrackssomeplatescanalsobesealed.

Re-sealingandpiercingarepossible.

96 INDI™ Seal

Applications

• Compoundstorage

• Sampleshipping


AnaluminiumheatsealthatsealstoPPandPSplatesandcanbepiercedwithapipettetiporpeeledbyhand.GoodsolventresistanceincludingDMSO.Resealingontoanexistingsealispossible.Aredcolourprintidentifiesthenon-sealingsurfaceforeaseofapplication.

Foil Seal

Applications

• Lowtemperaturecompoundstorage

• Short-termroomtemperaturecompoundstorage

• PCR

• Resealable



PEELABLE

A

UTOCLAVABLE

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PIERCEABLE

SE

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R

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PIERCEABLEPEELABLE

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R

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-195°

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4ti-0543 INDISealforindividualtubesealing

(125mmx78mmsheets) 50sheets








4ti-0536 100sheets(125mmx78mm)1 Compatible with Thermo Fisher ALPS 300™ / ALPS 3000™ /

KBiosystems Wasp™ / KBioscience FlexiSeal and Cube2 Compatible with Agilent (Velocity 11) PlateLoc®

3 Compatible with REMP Portrait Heat Sealer (PHS)4 Compatible with REMP Landscape / Stacking Heat

Sealers (LHS/SHS)


www.4ti.co.uk | 69 +44 (0)1306 884885

Hea

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alin

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Thisisaheavydutylaminatematerialthatsealstopolypropylenetogiveaverystrongbutpeelableseal.Thissealaffordsahighdegreeofsampleprotection.GoodsolventresistanceincludingDMSO.

Thermal Bond

Applications

• Longtermstorage,includingstorageandtransportationatlowtemperature

• Storageoforganicsolvents,acidsandalkalinesincludingDMSO

• PCR

• Suitableforwaterbaththermalcyclers

• Availableinsheetandrollformatsforautomatedsealers


A

UTOCLAVABLE

121o

PEELABLE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-200°

110°

Thepolystyrenefoilsealcreatesastrong,butpeelablesealtopolystyreneplates.Thesealcanalsobepiercedwithapipettetipandhasagoodsolventresistance,includingtoDMSO.Resealingontoanexistingsealispossible.

Polystyrene Foil Seal

Applications

• Lowtemperaturecompoundstorage

• Short-termroomtemperaturecompoundstorage

• Resealingispossible




PIERCEABLEPEELABLE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-20°

110°





4ti-0591 100sheets(125mmx78mm)5mx78mm

| www.4ti.co.uk70 +44 (0)1306 884885

Heat Sealing

Thisisafoil-basedheatsealwhichiscoatedonthesealingsurfacewithalowautofluorescenceblackpigmentforusewithlightsensitivesamplesorforfluorescentassays.TheBlackSealformsapeelablesealtopolystyreneplates.

Black Seal

Applications

• Fluorescentandotherlightsensitiveassays.

• Pierceswithaforcegreaterthan10N(ASTMD1000)

• Availableinsheetandrollformatsforautomatedsealers


1 Compatible with Thermo Fisher ALPS 300™ / ALPS 3000™

/ KBiosystems Wasp™ / KBioscience FlexiSeal and Cube2 Compatible with Agilent (Velocity 11) PlateLoc®





4ti-0527 100sheets(125mmx78mm

PEELABLE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-20°

80°

PIERCEABLE

ThisheatsealhasasmallerporesizethanthediscontiunedGasPermeableSeal(4ti-0596)whichstillallowsforgaseousexchange,butlimitsevaporation.Handlinginautomatedsealersisimproved.TheGasPermeableHeatSealMk2issuitableforcellcultureandisavailableassterileproductforthisapplication.

Gas Permeable Seal Mk 2

Applications

• Cellculture

• Overnightincubation

• Seedandinsectstorage

• Permeabilityrateis>20g/m2/24h

• Poresizeis<20µm

• Availableinsheetandrollformatforautomatedheatsealers


A

UTOCLAVABLE121o

PEELABLE

PIERCEABLESTERILE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E-20°

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4ti-0598 GasPermeableSealMk2roll(610mx78mm)1Approx5000seals 1roll

4ti-0598/ST GasPermeableSealMk2roll,sterile(610mx78mm)1

Approx5000seals 1roll

4ti-0599 GasPermeableSealMk2roll(500mx115mm)2Approx6200seals 1roll

4ti-0599/ST GasPermeableSealMk2roll,sterile(500mx115mm)2

Approx6200seals 1roll

4ti-0597 GasPermeableSealMk2sheets(125mmx78mm) 100sheets

4ti-0597/ST GasPermeableSealMk2sheets,sterile(125mmx78mm) 100sheets

(10packsx10sheets)

www.4ti.co.uk | 71 +44 (0)1306 884885

Hea

t Se

alin

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Gas Permeable Clear Seal

Applications

• Insectstudies

• Seedstorage



PEELABLE

SE

AL

INT

EG

R

ITY TEMPERATU

RE

RA

NG

E

-80°

110°

Thisisaclearpolymerfilmformingapeelablesealtopolypropylene,polyethylene,polystyreneandCOCplateswithgoodopticalclarityandmoderatesolventresistance.Thefilmhas3mmslitsacrosstheentirewidthoftherollorsheet,allowinggaseousexchange.DuetoitswidertemperaturetolerancecomparedtotheGasPermeableHeatSealitcanbeusedforstoragee.g.forseedsorinsects.


4ti-0540/SLIT 480mx78mmroll1Approx4000seals

4ti-0541/SLIT 100sheets(125mmx78mm)

1 Compatible with Thermo Fisher ALPS 300™ / ALPS 3000™

/ KBiosystems Wasp™ / KBioscience FlexiSeal and Cube2 Compatible with Agilent (Velocity 11) PlateLoc®


| www.4ti.co.uk72 +44 (0)1306 884885

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www.4ti.co.uk | 73 +44 (0)1306 884885

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Thistablemakesitsimplerforyoutoselecttherightheatsealforyoursealer:

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Heat Seal Selection Table

| www.4ti.co.uk74 +44 (0)1306 884885

Code Description Qty

4ti-0575/FS ClearWeldSealMkIIFrameSealTM,stackableheatsealframes 50

4ti-0541/FS ClearSealFrameSealTM 50

4ti-0531/FS PierceSealFrameSealTM 50COMING SOON

FrameSealTMutilisesasheetofstandard4titude®heatsealmaterialmountedontoadisposable,rigid,plasticframe.AFrameSealTMcanbeplacedeithermanuallyorwitharoboticgripperontoawiderangeofskirtedandsemi-skirtedmicroplatesincludingPCRplatesandarecompatiblewiththe4S3heatsealer.Aftersealing,thereistheoptiontoremovetheframebytearingalongpre-cutlinesleavingtheheatsealinplaceontheplatesurface.

FrameSeal™

Application example:

OurClearWeldSealMkII(4ti-0575)heatsealingfilmisnowavailablepre-mountedtocreateaFrameSeal.TogetherwithFraunhofferIPAInstituteFrameSealTMhasbeenusedinafullyintegratedsolutionforsealing1536wellPCRplatesbeforeanalysisofRNAiscreeningwithaRocheLightcycler1536.

Usingaroboticarm,asingleFrameSealTMisplacedontoa1536wellPCRplate.Byadjustingthepositionoftherobotgripper,theplateandFrameSealTMcombinationarethentransferredtothedrawofa4S3HeatSealerwhichsealsthepartviaasoftwarecommandthroughitsRS232port.

Afterthesealingprocesshasbeencarriedout,thesealedplateistransferredtotheDe-Framer,whichseperatestheframefromthefilmateachpointalongtheedgeofthefilm.Theframecanthenberemovedleavingthesealedplatetobeplacedinthecycler.

TogethertheheatsealerandtheFrameSealTMpresentedhereare:

• Themostcosteffectiveautomatedheatsealingsolutionavailable

• Anapproachinlinewithdemandsofdiagnosticsforasterile,single-useconsumable

• Themostcompactinstrumentforintegration

4s3™shownnexttotheDe-Framer

Automationcell,showingthe4LAB™,4s3™andDe-Framerfullyintegrated

Key advantages

• Keyadvantagescomparedtosheetsofsealingfilmorrollmaterial,aretheeaseofhandlingandtheabilitytosteriliseandimprovethequalitycontrolofeverysingleseal.

• TheFrameSealTMalsoenablestheuseofsheetedsealingmaterialinautomation.

NEW

COMING SOON

www.4ti.co.uk | 75 +44 (0)1306 884885 www.4ti.co.uk | 75 +44 (0)1306 884885

Documents

Heat Sealing - PCR Plates | Cell Screening Plates | Reaction Plates · 2016. 6. 6. · Fe56tdrTrsd edtt e rs nsdBrfds e it ntf12e 4rtdB3s Fechl Fels4sBSBpSs FeoOBgSBpSsg1ee46ssr eB12