H-SLuciferase

-1109 -19

N-SLuciferase-19-153

Full length EGFR promoter

1 303 588 671

1 303 588

1 303 588 671

303 588 671

wt

DDD

DID

DKD

Kinase domain Intermediate domain Death domain

Kinase domain

Kinase domain

Intermediate domain

Intermediate domain

Death domain

Death domain

RIP1 deletion mutants

Schematic diagram of full length and truncated EGFR promoters linked to firefly luciferase gene. The numbers indicate the nucleotide positions of the EGFR promoter relative to translation start site (ATG+1)

Schematic diagram of RIP1 and its mutants. RIP1 consists of three domains, Kinase, Intermediate and Death. The numbers indicate the amino acid positions of the protein.

Truncated EGFR promoter

Supplementary Figure 3 Ramnarain et al.