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W W W. N A T U R E . C O M / N A T U R E | 1
SUPPLEMENTARY INFORMATIONdoi:10.1038/nature25743
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Supplementary Data Figures
W W W. N A T U R E . C O M / N A T U R E | 3
SUPPLEMENTARY INFORMATION RESEARCH
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Supplementary Data Figure 1 | Sequence alignment of Piezo homologous.
Based on topology prediction and structurally resolved information, secondary structural elements of
mPiezo1 are indicated above the sequence alignment and color-coded for helices within different
THUs. Disease related mutations are indicated by triangles and pentacles below the sequences and
colored according to different diseases (red triangle for recessive generalized lymphatic dysplasia in
human Piezo1, yellow triangle for dominant dehydrated stomatocytosis/hereditary xerocytosis in
human Piezo1, green triangle for colorectal adenomatous polyposis in human Piezo1, blue pentacle
for scoliosis with peripheral sensory dysfunction in human Piezo2, purple pentacles for dominant
distal arthrogryposes type 3, type 5 (DA5), and Marden-Walker syndrome).
SUPPLEMENTARY INFORMATION
4 | W W W. N A T U R E . C O M / N A T U R E
RESEARCH
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Supplementary Data Figure 2 | Uncropped WB images related to Extended Data Figure 8c, d
and 9b